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Conserved domains on  [gi|392895794|ref|NP_001254958|]
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Putative DNA topoisomerase 2, mitochondrial [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
 44-126 5.21e-35

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 127.08  E-value: 5.21e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895794   44 AAKYEKKSPTEHVLLRPDTYIGGVAMREDQIiWLRDSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSS---MNRL 120
Cdd:PTZ00108    7 EERYQKKTQIEHILLRPDTYIGSIETQTEDM-WVYDEEKNRMVYKTITYVPGLYKIFDEILVNAADNKARDKGghrMTYI 85


                  ....*.
gi 392895794  121 EVWLDR 126
Cdd:PTZ00108   86 KVTIDE 91
 
Name Accession Description Interval E-value
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 44-126 5.21e-35

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 127.08  E-value: 5.21e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895794   44 AAKYEKKSPTEHVLLRPDTYIGGVAMREDQIiWLRDSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSS---MNRL 120
Cdd:PTZ00108    7 EERYQKKTQIEHILLRPDTYIGSIETQTEDM-WVYDEEKNRMVYKTITYVPGLYKIFDEILVNAADNKARDKGghrMTYI 85


                  ....*.
gi 392895794  121 EVWLDR 126
Cdd:PTZ00108   86 KVTIDE 91
HATPase_TopII-like cd16930
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ...
 92-126 7.62e-19

Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.


Pssm-ID: 340407 [Multi-domain]  Cd Length: 147  Bit Score: 76.61  E-value: 7.62e-19
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 392895794  92 YPPGLLKIFDEILVNAADNKARDSSMNRLEVWLDR 126
Cdd:cd16930    1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDP 35
TOP2c smart00433
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
 95-126 7.22e-09

TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE


Pssm-ID: 214659 [Multi-domain]  Cd Length: 594  Bit Score: 52.17  E-value: 7.22e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 392895794    95 GLLKIFDEILVNAADNKARDsSMNRLEVWLDR 126
Cdd:smart00433   1 GLHHLVDEIVDNAADEALAG-YMDTIKVTIDK 31
 
Name Accession Description Interval E-value
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 44-126 5.21e-35

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 127.08  E-value: 5.21e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895794   44 AAKYEKKSPTEHVLLRPDTYIGGVAMREDQIiWLRDSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSS---MNRL 120
Cdd:PTZ00108    7 EERYQKKTQIEHILLRPDTYIGSIETQTEDM-WVYDEEKNRMVYKTITYVPGLYKIFDEILVNAADNKARDKGghrMTYI 85


                  ....*.
gi 392895794  121 EVWLDR 126
Cdd:PTZ00108   86 KVTIDE 91
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 47-125 2.27e-32

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 119.43  E-value: 2.27e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392895794   47 YEKKSPTEHVLLRPDTYIGGVAmREDQIIWLrdSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSSMNRLEVWLD 125
Cdd:PLN03128    7 YQKKTQLEHILLRPDTYIGSTE-KHTQTLWV--YEGGEMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVDID 82
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 47-125 2.26e-27

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 105.33  E-value: 2.26e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392895794   47 YEKKSPTEHVLLRPDTYIGGVAMREdQIIWLrdSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSSMNRLEVWLD 125
Cdd:PLN03237   32 YQKKSQLEHILLRPDTYIGSIEKHT-QTLWV--YETDKMVQRSVTYVPGLYKIFDEILVNAADNKQRDPKMDSLRVVID 107
HATPase_TopII-like cd16930
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ...
 92-126 7.62e-19

Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.


Pssm-ID: 340407 [Multi-domain]  Cd Length: 147  Bit Score: 76.61  E-value: 7.62e-19
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 392895794  92 YPPGLLKIFDEILVNAADNKARDSSMNRLEVWLDR 126
Cdd:cd16930    1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDP 35
TOP2c smart00433
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
 95-126 7.22e-09

TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE


Pssm-ID: 214659 [Multi-domain]  Cd Length: 594  Bit Score: 52.17  E-value: 7.22e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 392895794    95 GLLKIFDEILVNAADNKARDsSMNRLEVWLDR 126
Cdd:smart00433   1 GLHHLVDEIVDNAADEALAG-YMDTIKVTIDK 31
39 PHA02569
DNA topoisomerase II large subunit; Provisional
 51-125 1.04e-08

DNA topoisomerase II large subunit; Provisional


Pssm-ID: 177398 [Multi-domain]  Cd Length: 602  Bit Score: 51.68  E-value: 1.04e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392895794  51 SPTEHVLLRPDTYIGGVAmredqiiwlRDSENRKMIAK--EVTYPPGLLKIFDEILVNAADNKARDS--SMNRLEVWLD 125
Cdd:PHA02569   8 SDREHILKRPGMYIGSVA---------YEAHERFLFGKftQVEYVPGLVKIIDEIIDNSVDEAIRTNfkFANKIDVTIK 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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