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Conserved domains on  [gi|392901269|ref|NP_001255661|]
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Prokaryotic-type class I peptide chain release factors domain-containing protein [Caenorhabditis elegans]

Protein Classification

peptide chain release factor family protein( domain architecture ID 10452619)

peptide chain release factor family protein such as mitochondrial translation release factor in rescue (MTRFR) that is part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation

CATH:  3.30.160.20
Gene Ontology:  GO:0003747
PubMed:  1408743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 41-117 3.27e-14

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


:

Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 63.98  E-value: 3.27e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392901269   41 GPGGQKVNTAQNAVQLTHLPTGTVLKVHESRLLPKNIDIAFERMKFVLDRQINGENCYEEQLKRLQIAKEEKSNKRR 117
Cdd:pfam00472  21 GAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEEKKRRIKSQVGSGDRSEQIR 97
 
Name Accession Description Interval E-value
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 41-117 3.27e-14

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 63.98  E-value: 3.27e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392901269   41 GPGGQKVNTAQNAVQLTHLPTGTVLKVHESRLLPKNIDIAFERMKFVLDRQINGENCYEEQLKRLQIAKEEKSNKRR 117
Cdd:pfam00472  21 GAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEEKKRRIKSQVGSGDRSEQIR 97
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 26-114 6.01e-09

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 52.57  E-value: 6.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901269  26 DVRKEDCEQKYISGWGPGGQKVNTAQNAVQLTHLPTGTVLKVHESRLLPKNIDIAFERMKFVLdrqingencYEEQLKRl 105
Cdd:PRK07342 195 DVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQHKNRAKAWSMLRARL---------YEEELKK- 264


                 ....*....
gi 392901269 106 qiaKEEKSN 114
Cdd:PRK07342 265 ---REEATN 270
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 41-64 7.53e-08

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 49.23  E-value: 7.53e-08
                         10        20
                 ....*....|....*....|....
gi 392901269  41 GPGGQKVNTAQNAVQLTHLPTGTV 64
Cdd:COG0216  230 GAGGQHVNTTDSAVRITHLPTGIV 253
 
Name Accession Description Interval E-value
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 41-117 3.27e-14

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 63.98  E-value: 3.27e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392901269   41 GPGGQKVNTAQNAVQLTHLPTGTVLKVHESRLLPKNIDIAFERMKFVLDRQINGENCYEEQLKRLQIAKEEKSNKRR 117
Cdd:pfam00472  21 GAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEEKKRRIKSQVGSGDRSEQIR 97
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 26-114 6.01e-09

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 52.57  E-value: 6.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901269  26 DVRKEDCEQKYISGWGPGGQKVNTAQNAVQLTHLPTGTVLKVHESRLLPKNIDIAFERMKFVLdrqingencYEEQLKRl 105
Cdd:PRK07342 195 DVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQHKNRAKAWSMLRARL---------YEEELKK- 264


                 ....*....
gi 392901269 106 qiaKEEKSN 114
Cdd:PRK07342 265 ---REEATN 270
prfA PRK00591
peptide chain release factor 1; Validated
 41-124 2.40e-08

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 50.85  E-value: 2.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901269  41 GPGGQKVNTAQNAVQLTHLPTGTVLKVHESRLLPKNIDIAferMKfVLDRQIngencYEEQLKRLQiakEEKSNKRRVQA 120
Cdd:PRK00591 232 GAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKA---MK-VLRARL-----YDAERQKAQ---AEEAATRKSQV 299


                 ....*...
gi 392901269 121 ----RKEK 124
Cdd:PRK00591 300 gsgdRSER 307
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 41-64 7.53e-08

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 49.23  E-value: 7.53e-08
                         10        20
                 ....*....|....*....|....
gi 392901269  41 GPGGQKVNTAQNAVQLTHLPTGTV 64
Cdd:COG0216  230 GAGGQHVNTTDSAVRITHLPTGIV 253
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 41-122 4.46e-07

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 45.89  E-value: 4.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901269  41 GPGGQKVNTAQNAVQLTH------------LPTGTVLKVHESRLLPKNIDIAFERMKFVLdRQIngencYEEQLKRLQIA 108
Cdd:COG1186   37 GAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALL-YEA-----ELEPKERRATK 110

                         90
                 ....*....|....
gi 392901269 109 KEEKSNKRRVQARK 122
Cdd:COG1186  111 PTRGSKKRRLWGKQ 124
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 26-112 7.61e-06

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 43.57  E-value: 7.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901269  26 DVRKEDCEQKYISGWGPGGQKVNTAQNAVQLTHLPTGTVLKVHESRLLPKNIDIAFERMKFVLDRQingeNCYEEQLKRL 105
Cdd:PRK06746 193 EVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKMLKAKLYQK----KLEEQQAELD 268


                 ....*..
gi 392901269 106 QIAKEEK 112
Cdd:PRK06746 269 EIRGEQK 275
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 26-85 1.25e-05

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 43.25  E-value: 1.25e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901269  26 DVRKEDCEQKYISGWGPGGQKVNTAQNAVQLTHLPTGTVLKVHESRLLPKNIDIAFERMK 85
Cdd:PRK05589 192 EIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHSNKETAMKMLK 251
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 41-84 2.82e-05

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 41.95  E-value: 2.82e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 392901269  41 GPGGQKVNTAQNAVQLTHLPTGTVLKVHESRLLPKNIDIAFERM 84
Cdd:PRK08787 187 GAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKML 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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