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Conserved domains on  [gi|392901521|ref|NP_001255727|]
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Meiotic recombination protein rec-8 [Caenorhabditis elegans]

Protein Classification

Rad21/Rec8 N-terminal domain-containing protein( domain architecture ID 10521797)

Rad21/Rec8 N-terminal domain-containing protein similar to Saccharomyces cerevisiae meiotic recombination protein REC8 that replaces the SCC1 mitosis-specific cohesin to ensure sister chromatid cohesion during meiosis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rad21_Rec8_N pfam04825
N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region ...
 1-87 1.78e-17

N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


:

Pssm-ID: 461446  Cd Length: 104  Bit Score: 78.36  E-value: 1.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901521    1 MVVSAEVIRKDAVFHVAWILGTGDsKKLSRREILDQNLPELCHSIIEmvPErhrgsaTKTGLYLLSLLTYGTVLIHQVQV 80
Cdd:pfam04825   1 MFYSHEILSKKGPLATVWLAATLG-KKLSKKQILEVDIPKACETIIN--PE------APLALRLSGQLLLGVVRIYSRKA 71


                  ....*..
gi 392901521   81 DFLKRDV 87
Cdd:pfam04825  72 KYLLDDC 78
 
Name Accession Description Interval E-value
Rad21_Rec8_N pfam04825
N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region ...
 1-87 1.78e-17

N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 461446  Cd Length: 104  Bit Score: 78.36  E-value: 1.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901521    1 MVVSAEVIRKDAVFHVAWILGTGDsKKLSRREILDQNLPELCHSIIEmvPErhrgsaTKTGLYLLSLLTYGTVLIHQVQV 80
Cdd:pfam04825   1 MFYSHEILSKKGPLATVWLAATLG-KKLSKKQILEVDIPKACETIIN--PE------APLALRLSGQLLLGVVRIYSRKA 71


                  ....*..
gi 392901521   81 DFLKRDV 87
Cdd:pfam04825  72 KYLLDDC 78
 
Name Accession Description Interval E-value
Rad21_Rec8_N pfam04825
N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region ...
 1-87 1.78e-17

N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 461446  Cd Length: 104  Bit Score: 78.36  E-value: 1.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392901521    1 MVVSAEVIRKDAVFHVAWILGTGDsKKLSRREILDQNLPELCHSIIEmvPErhrgsaTKTGLYLLSLLTYGTVLIHQVQV 80
Cdd:pfam04825   1 MFYSHEILSKKGPLATVWLAATLG-KKLSKKQILEVDIPKACETIIN--PE------APLALRLSGQLLLGVVRIYSRKA 71


                  ....*..
gi 392901521   81 DFLKRDV 87
Cdd:pfam04825  72 KYLLDDC 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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