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Conserved domains on  [gi|392919465|ref|NP_001256084|]
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Serpentine Receptor, class J [Caenorhabditis elegans]

Protein Classification

serpentine receptor( domain architecture ID 366230)

serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srd super family cl22924
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 2-221 6.77e-75

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10319:

Pssm-ID: 419896  Cd Length: 310  Bit Score: 229.44  E-value: 6.77e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919465    2 LLLAIRCSLIACTYTILISHFVYRYLAVLGSIFINRLF-PYFMIVTLLFCVIASMFWIMIAYFVAVPNFEVRHYIQQNMY 80
Cdd:pfam10319  90 HALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFrPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFR 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919465   81 EIYGADSITLNFFALLYQESTLETEIKSWIGVIAGSLVSILSIFILMILKFQIRKKLQSDRYRMSAGTAKMQLELLRSLV 160
Cdd:pfam10319 170 ETYGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKALI 249

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392919465  161 VQTVIPIIFSLAPCMLSWFTPMFNLKLDKWLNYTSAVPLSAFPFIDPFAVILCLPAFRRRL 221
Cdd:pfam10319 250 VQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 2-221 6.77e-75

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 229.44  E-value: 6.77e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919465    2 LLLAIRCSLIACTYTILISHFVYRYLAVLGSIFINRLF-PYFMIVTLLFCVIASMFWIMIAYFVAVPNFEVRHYIQQNMY 80
Cdd:pfam10319  90 HALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFrPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFR 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919465   81 EIYGADSITLNFFALLYQESTLETEIKSWIGVIAGSLVSILSIFILMILKFQIRKKLQSDRYRMSAGTAKMQLELLRSLV 160
Cdd:pfam10319 170 ETYGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKALI 249

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392919465  161 VQTVIPIIFSLAPCMLSWFTPMFNLKLDKWLNYTSAVPLSAFPFIDPFAVILCLPAFRRRL 221
Cdd:pfam10319 250 VQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 2-221 6.77e-75

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 229.44  E-value: 6.77e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919465    2 LLLAIRCSLIACTYTILISHFVYRYLAVLGSIFINRLF-PYFMIVTLLFCVIASMFWIMIAYFVAVPNFEVRHYIQQNMY 80
Cdd:pfam10319  90 HALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFrPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFR 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919465   81 EIYGADSITLNFFALLYQESTLETEIKSWIGVIAGSLVSILSIFILMILKFQIRKKLQSDRYRMSAGTAKMQLELLRSLV 160
Cdd:pfam10319 170 ETYGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKALI 249

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392919465  161 VQTVIPIIFSLAPCMLSWFTPMFNLKLDKWLNYTSAVPLSAFPFIDPFAVILCLPAFRRRL 221
Cdd:pfam10319 250 VQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 1-222 1.84e-31

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 117.17  E-value: 1.84e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919465    1 MLLLAIRCSLIACTYTILISHFVYRYLAVLGSIFINRLFPYFMIVTLLFCVIASMFWIMIAYFVAVPNFEVRHYIQQNMY 80
Cdd:pfam10326  83 QILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELL 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919465   81 EIYGADSITLNFFALLYQESTLETE----IKSWIGVIAGSLVSILSIFILMILKFQIRKKLQSDRYRMSAGTAKMQLELL 156
Cdd:pfam10326 163 ENYNLDIDEVAYVGPVYYPTDENGSkvirWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLF 242

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392919465  157 RSLVVQTVIPIIFSLAPCMLSWFTPMFNLKLDKWLNYTSAVpLSAFPFIDPFAVILCLPAFRRRLL 222
Cdd:pfam10326 243 KALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITAT-IALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 109-184 2.05e-05

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 44.46  E-value: 2.05e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392919465  109 WIGVIAGSLVSILSIFILMILKFQIRKKLQSDRYRMSAGTAKMQLELLRSLVVQTVIPIIFSLAPCMLSWFTPMFN 184
Cdd:pfam10318 185 YFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFG 260
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
 2-176 1.81e-04

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 41.76  E-value: 1.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919465    2 LLLAIRCSLIACTYTILISHFVYRYLAVLGSIFINRLFPYFMIVTLLFCVIASMFWIMIAYFVAVPNFEVRHYIQQNmYE 81
Cdd:pfam10327  92 YLMTIFVFLLSFQLESLLLCFVRKHQAIAKILSKHVIPKWLYIFLYILCHIFPFLTAFLFYQSGLSREEQLEYVKEN-YP 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919465   82 IYGADSITLNFFALlYQESTLETeikswIGVIAGSLVSILSIFILMILKFQIRKKLQSDRYRMSAGTAKMQLELLRSLVV 161
Cdd:pfam10327 171 EYLSQFSSLPNFAI-YDYNPWLI-----VFGILAIFGGSLSFLILVYLTVDMFRMLKRLRKKISAQTYQKHRAALRSLIA 244

                         170
                  ....*....|....*
gi 392919465  162 QTVIPIIFSLAPCML 176
Cdd:pfam10327 245 QFATSPVCILPPFAF 259
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 8-222 3.55e-03

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 37.92  E-value: 3.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919465    8 CSLIACTYTILIShFVYRYLAVlgsifiNRLFPYFMIVTLLFCVIASMFWIM-IAYFVAVPNFEVRHYIQQNMYEIYGAD 86
Cdd:pfam10317  91 HFLLHSGWSLLLT-FYYRYYIL------KHVDPKRKKLILLIIIHYIPSLSQlIVIFLSPTDFLPVEALTKELHPNYNLT 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919465   87 SITLNFFallyqestleTEIKSWIGVIAGSLVSILSIFILMI---LKFQIRKKLQSDRYRMSAGTAKMQLELLRSLVVQT 163
Cdd:pfam10317 164 DYTVTGF----------SDLQSFPALINTLIMTIPVFPIPIIiliLRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQA 233

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 392919465  164 VIPIIFSLAPCMLSWFTPMFNLKLDKwLNYTSAVPLSAFPFIDPFAVILCLPAFRRRLL 222
Cdd:pfam10317 234 LLPLFSYIPGVTLYLLSQLTGTEFLI-LEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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