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Conserved domains on  [gi|392919598|ref|NP_001256094|]
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Sodium/calcium exchanger membrane region domain-containing protein [Caenorhabditis elegans]

Protein Classification

PLN03151 and Na_Ca_ex domain-containing protein( domain architecture ID 13327675)

PLN03151 and Na_Ca_ex domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03151 super family cl33648
cation/calcium exchanger; Provisional
 35-571 1.74e-30

cation/calcium exchanger; Provisional


The actual alignment was detected with superfamily member PLN03151:

Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 127.19  E-value: 1.74e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598  35 NSNTPRNASRLVLTDE---LCSQdeclIQKHWTREDTCAYIKCNKDaCEGGGYLQWSE--YIKCEHSRSIRIILIIISII 109
Cdd:PLN03151  74 DVNSSYFSDNSSLSGDspvLCSG----LHEHEGYADQCEFLKAHPI-CSSGGFFDYLKffYCSCEDFRILGYAVLGVWLV 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 110 YllfLFVVMTVVADDFFSPSIAGIVRHLKISESIAGVTFLAFGNGAPDVFGSIASVITtpKPKADLAIGDIIGGGIFVTT 189
Cdd:PLN03151 149 A---LFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFASIAAFVG--KDAGEVGLNSVLGGAVFVTC 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 190 VVLSAIILT---KSFRIAILATIRDIVFFIIADIFLAIwFLTFNHVEIWMPLTFLGLYAAYVVSVIlmrLNSKRRKRARH 266
Cdd:PLN03151 224 VVVGIVSLCvadKEVQIDKRCFIRDLCFFLFTLVSLLV-ILMVGKVTVGGAIAFVSIYVVYAFLVA---ANEILRKHARR 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 267 EKIEnarkesamnhhthkistfigffmdyahvinffANNKISSMTNNVKNFLDGKEDSLEDGLVDETSDDegveaefhya 346
Cdd:PLN03151 300 LKLD--------------------------------VVTPLLPVQGSIFSPSVEEDESMYSPLLESDTES---------- 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 347 hrhvyksydeaslaftDVEEIQPKTwKSWEWVRDV---RNHLR----------PWPGNDEFYEMN----YFSRFITVVAV 409
Cdd:PLN03151 338 ----------------DVPRLQTSL-PQWMWASNVaiySNHFAkgsvhdeerpPWGWTDEGAEVEsslfSCSKLFSLLEM 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 410 IPTFFLKLTIPS-NEMPWSKPILIIH-CFCSIQLA-LFAVQISAKSPFHGSPglWLYGLLISIILSLLALRFTPLDREQK 486
Cdd:PLN03151 401 PLTIPRRLTIPIvEEDRWSKTYAVASaSLAPVLLAfLWSSQDDVSLQARIAA--YFIGVAIGSTLGFLAYKYTEPDRPPR 478

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 487 YYREVYSYLGFLMSIAWIYTISSEIINVITMIGVATGVSQEILGLTIMAWSNCIGDIVSDVAVVKQGFP--KMAMAAAIG 564
Cdd:PLN03151 479 RFLIPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNGGDgvQIAMSGCYA 558


                 ....*..
gi 392919598 565 GPLFSKL 571
Cdd:PLN03151 559 GPMFNTL 565
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 492-659 4.61e-21

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


:

Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 89.97  E-value: 4.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598  492 YSYLGFLMSIAWIYTISSEIINVITMIGVATGVSQEILGLTIMAWSNCIGDIVSDVAVVKQGFPKMAMAAAIGGPLFskl 571
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIF--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598  572 ysrpcqikittyisDLLIGFGLPFTIACLQGKQIDLIITPvyrLLMLFLAISLFTSLIAIFVQRF-KVRWPHAVALLTVF 650
Cdd:pfam01699  78 --------------NILLVLGLSALIGPVKVDSLLLKLDL---GVLLLVALLLLLLLLLLLLPLFgRLSRFEGLVLLLLY 140


                  ....*....
gi 392919598  651 VAFLIFVLL 659
Cdd:pfam01699 141 IVYLVFQIV 149
 
Name Accession Description Interval E-value
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 35-571 1.74e-30

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 127.19  E-value: 1.74e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598  35 NSNTPRNASRLVLTDE---LCSQdeclIQKHWTREDTCAYIKCNKDaCEGGGYLQWSE--YIKCEHSRSIRIILIIISII 109
Cdd:PLN03151  74 DVNSSYFSDNSSLSGDspvLCSG----LHEHEGYADQCEFLKAHPI-CSSGGFFDYLKffYCSCEDFRILGYAVLGVWLV 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 110 YllfLFVVMTVVADDFFSPSIAGIVRHLKISESIAGVTFLAFGNGAPDVFGSIASVITtpKPKADLAIGDIIGGGIFVTT 189
Cdd:PLN03151 149 A---LFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFASIAAFVG--KDAGEVGLNSVLGGAVFVTC 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 190 VVLSAIILT---KSFRIAILATIRDIVFFIIADIFLAIwFLTFNHVEIWMPLTFLGLYAAYVVSVIlmrLNSKRRKRARH 266
Cdd:PLN03151 224 VVVGIVSLCvadKEVQIDKRCFIRDLCFFLFTLVSLLV-ILMVGKVTVGGAIAFVSIYVVYAFLVA---ANEILRKHARR 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 267 EKIEnarkesamnhhthkistfigffmdyahvinffANNKISSMTNNVKNFLDGKEDSLEDGLVDETSDDegveaefhya 346
Cdd:PLN03151 300 LKLD--------------------------------VVTPLLPVQGSIFSPSVEEDESMYSPLLESDTES---------- 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 347 hrhvyksydeaslaftDVEEIQPKTwKSWEWVRDV---RNHLR----------PWPGNDEFYEMN----YFSRFITVVAV 409
Cdd:PLN03151 338 ----------------DVPRLQTSL-PQWMWASNVaiySNHFAkgsvhdeerpPWGWTDEGAEVEsslfSCSKLFSLLEM 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 410 IPTFFLKLTIPS-NEMPWSKPILIIH-CFCSIQLA-LFAVQISAKSPFHGSPglWLYGLLISIILSLLALRFTPLDREQK 486
Cdd:PLN03151 401 PLTIPRRLTIPIvEEDRWSKTYAVASaSLAPVLLAfLWSSQDDVSLQARIAA--YFIGVAIGSTLGFLAYKYTEPDRPPR 478

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 487 YYREVYSYLGFLMSIAWIYTISSEIINVITMIGVATGVSQEILGLTIMAWSNCIGDIVSDVAVVKQGFP--KMAMAAAIG 564
Cdd:PLN03151 479 RFLIPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNGGDgvQIAMSGCYA 558


                 ....*..
gi 392919598 565 GPLFSKL 571
Cdd:PLN03151 559 GPMFNTL 565
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 492-659 4.61e-21

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 89.97  E-value: 4.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598  492 YSYLGFLMSIAWIYTISSEIINVITMIGVATGVSQEILGLTIMAWSNCIGDIVSDVAVVKQGFPKMAMAAAIGGPLFskl 571
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIF--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598  572 ysrpcqikittyisDLLIGFGLPFTIACLQGKQIDLIITPvyrLLMLFLAISLFTSLIAIFVQRF-KVRWPHAVALLTVF 650
Cdd:pfam01699  78 --------------NILLVLGLSALIGPVKVDSLLLKLDL---GVLLLVALLLLLLLLLLLLPLFgRLSRFEGLVLLLLY 140


                  ....*....
gi 392919598  651 VAFLIFVLL 659
Cdd:pfam01699 141 IVYLVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 113-253 1.85e-16

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 76.87  E-value: 1.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598  113 FLFVVMTVVADDFFSPSIAGIVRHLKISESIAGVTFLAFGNGAPDVFGSIASVIttpKPKADLAIGDIIGGGIFVTTVVL 192
Cdd:pfam01699   7 ILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAAL---RGEPDLALGNVIGSNIFNILLVL 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392919598  193 SAIILTKSFRIAILATIRD-----IVFFIIADIFLAIWFLTFNHVEIWMPLTFLGLYAAYVVSVIL 253
Cdd:pfam01699  84 GLSALIGPVKVDSLLLKLDlgvllLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 113-257 3.61e-10

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 63.48  E-value: 3.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598   113 FLFVVMTVVADDFFSPSIAGIVRHLKISESIAGVTFLAFGNGAPDVFGSIASVITTpkpKADLAIGDIIGGGIFVTTVVL 192
Cdd:TIGR00927  466 YVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFIS---HSNVGIGTIVGSAVFNILFVI 542

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598   193 SAIILtksFRIAIL-----ATIRDIVFFIIaDIFLAIWFLTFNHVEIWMPLTFLGLYAAYVVSvilMRLN 257
Cdd:TIGR00927  543 GTCAL---FSREILnltwwPLFRDVSFYIL-DLMMLILFFLDSLIAWWESLLLLLAYALYVFT---MKWN 605
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
124-279 5.66e-09

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 57.84  E-value: 5.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 124 DFFSPSIAGIVRHLKISESIAGVTFLAFGNGAPDVFGSIASVIttpKPKADLAIGDIIGGGIFVTTVVLSAIILTKSFRI 203
Cdd:COG0530    2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAAL---DGSPDIAVGNVVGSNIANILLILGLAALIRPLAV 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392919598 204 AILATIRDIVFFIIAdIFLAIWFLTFNHVEIWMPLTFLGLYAAYVVSVIlmrlNSKRRKRARHEKIENARKESAMN 279
Cdd:COG0530   79 DRRVLRRDLPFLLLA-SLLLLALLLDGTLSRIDGVILLLLYVLYLYYLI----RRARKEPAWEEVEEELEEKPKMS 149
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 497-660 1.11e-08

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 58.47  E-value: 1.11e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598   497 FLMSIAWIYTISSEIINVITMIGVATGVSQEILGLTIMAWSNCIGDIVSDVAVVKQGFPKMAMAAAIGGPLFsklysrpc 576
Cdd:TIGR00927  938 FLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIF-------- 1009

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598   577 qikittyisDLLIGFGLPFT----IACLQGKQID---LIITPVYRLLMLFLAISLFTSliaifvqrfkVRWPHAVAL-LT 648
Cdd:TIGR00927 1010 ---------DITVGLPVPWLlfslINGLQPVPVSsngLFCAIVLLFLMLLFVISSIAS----------CKWRMNKILgFT 1070

                          170
                   ....*....|..
gi 392919598   649 VFVAFLIFVLLS 660
Cdd:TIGR00927 1071 MFLLYFVFLIIS 1082
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
495-657 1.06e-05

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 47.82  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 495 LGFLMSIAWIYTISSEIINVITMIGVATGVSQEILGLTIMAwsncIG----DIVSDVAVVKQGFPKMAMAAAIGGPLFsk 570
Cdd:COG0530  155 LLLVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVA----IGtslpELATSIVAARKGEDDLAVGNIIGSNIF-- 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 571 lysrpcqikittyisDLLIGFGLPFTIAclqGKQIDLIITPVYRLLMLFLAISLFtsliAIFVQRFKVRWPHAVALLTVF 650
Cdd:COG0530  229 ---------------NILLVLGIGALIT---PIPVDPAVLSFDLPVMLAATLLLL----GLLRTGGRIGRWEGLLLLALY 286


                 ....*..
gi 392919598 651 VAFLIFV 657
Cdd:COG0530  287 LAYLALL 293
 
Name Accession Description Interval E-value
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 35-571 1.74e-30

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 127.19  E-value: 1.74e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598  35 NSNTPRNASRLVLTDE---LCSQdeclIQKHWTREDTCAYIKCNKDaCEGGGYLQWSE--YIKCEHSRSIRIILIIISII 109
Cdd:PLN03151  74 DVNSSYFSDNSSLSGDspvLCSG----LHEHEGYADQCEFLKAHPI-CSSGGFFDYLKffYCSCEDFRILGYAVLGVWLV 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 110 YllfLFVVMTVVADDFFSPSIAGIVRHLKISESIAGVTFLAFGNGAPDVFGSIASVITtpKPKADLAIGDIIGGGIFVTT 189
Cdd:PLN03151 149 A---LFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFASIAAFVG--KDAGEVGLNSVLGGAVFVTC 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 190 VVLSAIILT---KSFRIAILATIRDIVFFIIADIFLAIwFLTFNHVEIWMPLTFLGLYAAYVVSVIlmrLNSKRRKRARH 266
Cdd:PLN03151 224 VVVGIVSLCvadKEVQIDKRCFIRDLCFFLFTLVSLLV-ILMVGKVTVGGAIAFVSIYVVYAFLVA---ANEILRKHARR 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 267 EKIEnarkesamnhhthkistfigffmdyahvinffANNKISSMTNNVKNFLDGKEDSLEDGLVDETSDDegveaefhya 346
Cdd:PLN03151 300 LKLD--------------------------------VVTPLLPVQGSIFSPSVEEDESMYSPLLESDTES---------- 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 347 hrhvyksydeaslaftDVEEIQPKTwKSWEWVRDV---RNHLR----------PWPGNDEFYEMN----YFSRFITVVAV 409
Cdd:PLN03151 338 ----------------DVPRLQTSL-PQWMWASNVaiySNHFAkgsvhdeerpPWGWTDEGAEVEsslfSCSKLFSLLEM 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 410 IPTFFLKLTIPS-NEMPWSKPILIIH-CFCSIQLA-LFAVQISAKSPFHGSPglWLYGLLISIILSLLALRFTPLDREQK 486
Cdd:PLN03151 401 PLTIPRRLTIPIvEEDRWSKTYAVASaSLAPVLLAfLWSSQDDVSLQARIAA--YFIGVAIGSTLGFLAYKYTEPDRPPR 478

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 487 YYREVYSYLGFLMSIAWIYTISSEIINVITMIGVATGVSQEILGLTIMAWSNCIGDIVSDVAVVKQGFP--KMAMAAAIG 564
Cdd:PLN03151 479 RFLIPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNGGDgvQIAMSGCYA 558


                 ....*..
gi 392919598 565 GPLFSKL 571
Cdd:PLN03151 559 GPMFNTL 565
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 492-659 4.61e-21

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 89.97  E-value: 4.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598  492 YSYLGFLMSIAWIYTISSEIINVITMIGVATGVSQEILGLTIMAWSNCIGDIVSDVAVVKQGFPKMAMAAAIGGPLFskl 571
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIF--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598  572 ysrpcqikittyisDLLIGFGLPFTIACLQGKQIDLIITPvyrLLMLFLAISLFTSLIAIFVQRF-KVRWPHAVALLTVF 650
Cdd:pfam01699  78 --------------NILLVLGLSALIGPVKVDSLLLKLDL---GVLLLVALLLLLLLLLLLLPLFgRLSRFEGLVLLLLY 140


                  ....*....
gi 392919598  651 VAFLIFVLL 659
Cdd:pfam01699 141 IVYLVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 113-253 1.85e-16

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 76.87  E-value: 1.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598  113 FLFVVMTVVADDFFSPSIAGIVRHLKISESIAGVTFLAFGNGAPDVFGSIASVIttpKPKADLAIGDIIGGGIFVTTVVL 192
Cdd:pfam01699   7 ILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAAL---RGEPDLALGNVIGSNIFNILLVL 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392919598  193 SAIILTKSFRIAILATIRD-----IVFFIIADIFLAIWFLTFNHVEIWMPLTFLGLYAAYVVSVIL 253
Cdd:pfam01699  84 GLSALIGPVKVDSLLLKLDlgvllLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 113-257 3.61e-10

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 63.48  E-value: 3.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598   113 FLFVVMTVVADDFFSPSIAGIVRHLKISESIAGVTFLAFGNGAPDVFGSIASVITTpkpKADLAIGDIIGGGIFVTTVVL 192
Cdd:TIGR00927  466 YVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFIS---HSNVGIGTIVGSAVFNILFVI 542

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598   193 SAIILtksFRIAIL-----ATIRDIVFFIIaDIFLAIWFLTFNHVEIWMPLTFLGLYAAYVVSvilMRLN 257
Cdd:TIGR00927  543 GTCAL---FSREILnltwwPLFRDVSFYIL-DLMMLILFFLDSLIAWWESLLLLLAYALYVFT---MKWN 605
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
124-279 5.66e-09

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 57.84  E-value: 5.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 124 DFFSPSIAGIVRHLKISESIAGVTFLAFGNGAPDVFGSIASVIttpKPKADLAIGDIIGGGIFVTTVVLSAIILTKSFRI 203
Cdd:COG0530    2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAAL---DGSPDIAVGNVVGSNIANILLILGLAALIRPLAV 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392919598 204 AILATIRDIVFFIIAdIFLAIWFLTFNHVEIWMPLTFLGLYAAYVVSVIlmrlNSKRRKRARHEKIENARKESAMN 279
Cdd:COG0530   79 DRRVLRRDLPFLLLA-SLLLLALLLDGTLSRIDGVILLLLYVLYLYYLI----RRARKEPAWEEVEEELEEKPKMS 149
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 497-660 1.11e-08

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 58.47  E-value: 1.11e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598   497 FLMSIAWIYTISSEIINVITMIGVATGVSQEILGLTIMAWSNCIGDIVSDVAVVKQGFPKMAMAAAIGGPLFsklysrpc 576
Cdd:TIGR00927  938 FLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIF-------- 1009

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598   577 qikittyisDLLIGFGLPFT----IACLQGKQID---LIITPVYRLLMLFLAISLFTSliaifvqrfkVRWPHAVAL-LT 648
Cdd:TIGR00927 1010 ---------DITVGLPVPWLlfslINGLQPVPVSsngLFCAIVLLFLMLLFVISSIAS----------CKWRMNKILgFT 1070

                          170
                   ....*....|..
gi 392919598   649 VFVAFLIFVLLS 660
Cdd:TIGR00927 1071 MFLLYFVFLIIS 1082
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 114-288 1.97e-08

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 56.18  E-value: 1.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598  114 LFVVMTVVADDFFSPSIAGIVRHLKISESIAGVTFLAFGNGAPDVFGSIASVITTpkpKADLAigdiigggifVTTVVLS 193
Cdd:TIGR00367   9 LGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMG---QPDIG----------VGNVIGS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598  194 AII-------LTKSFRIAILAT---IRDIVFFIIADIFLAIWFLTFNhveiWMPLTFLGLYAAYVVsviLMRLNSkrrKR 263
Cdd:TIGR00367  76 NIFnillilgLSAIFSPIIVDKdwlRRDILFYLLVSILLLFFGLDGQ----ISRIDGVVLLILYIV---YLLFLV---KN 145

                         170       180
                  ....*....|....*....|....*
gi 392919598  264 ARHEKIENARKESAMNHHTHKISTF 288
Cdd:TIGR00367 146 ERWVKYDTYTEENLDENNRRPQIFF 170
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
116-249 3.89e-07

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 52.06  E-value: 3.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 116 VVMTVVADDFFSPSIAGIVRHLKISESIAGVTFLAFGNGAPDVFGSIASVIttpKPKADLAIGDIIGGGIFVTTVVLSAI 195
Cdd:COG0530  161 LALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAAR---KGEDDLAVGNIIGSNIFNILLVLGIG 237

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 392919598 196 ILTKSFRIAILATIRDIVFFIIADIFLAIWFLTFNHVEIWMPLTFLGLYAAYVV 249
Cdd:COG0530  238 ALITPIPVDPAVLSFDLPVMLAATLLLLGLLRTGGRIGRWEGLLLLALYLAYLA 291
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
495-657 1.06e-05

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 47.82  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 495 LGFLMSIAWIYTISSEIINVITMIGVATGVSQEILGLTIMAwsncIG----DIVSDVAVVKQGFPKMAMAAAIGGPLFsk 570
Cdd:COG0530  155 LLLVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVA----IGtslpELATSIVAARKGEDDLAVGNIIGSNIF-- 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 571 lysrpcqikittyisDLLIGFGLPFTIAclqGKQIDLIITPVYRLLMLFLAISLFtsliAIFVQRFKVRWPHAVALLTVF 650
Cdd:COG0530  229 ---------------NILLVLGIGALIT---PIPVDPAVLSFDLPVMLAATLLLL----GLLRTGGRIGRWEGLLLLALY 286


                 ....*..
gi 392919598 651 VAFLIFV 657
Cdd:COG0530  287 LAYLALL 293
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
518-668 4.38e-03

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 39.73  E-value: 4.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598 518 IGVATGVSQEILGLTIMAWSNCIGDIVSDVAVVKQGFPKMAMAAAIGGPLFsklysrpcqikittyisdlLIGFGLPfti 597
Cdd:COG0530   11 LARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIA-------------------NILLILG--- 68

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392919598 598 aclqgkqIDLIITP-------VYRLLMLFLAISLftsLIAIFVQRFKVRWPHAVALLTVFVAFLIFVLLSETHTLEWN 668
Cdd:COG0530   69 -------LAALIRPlavdrrvLRRDLPFLLLASL---LLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARKEPAWE 136
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 114-247 9.23e-03

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 38.84  E-value: 9.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598  114 LFVVMTVVADDFFSPSIAGIVRHLKISESIAGVTFLAFGNGAPDVFGSIASVIttpKPKADLAIGDIIGGGIFVTTVVLS 193
Cdd:TIGR00367 177 IGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAAR---KGLGDIAVGNVIGSNIFNILVGLG 253

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 392919598  194 AIILTKSFRIAILATIRDIVFFIIADIFLAIWFLTFNHVEIWMPLTFLGLYAAY 247
Cdd:TIGR00367 254 VPSLFMPIPVEPLAYNLDAPVMVIVTLLLMLFFKTSMKLGRWEGILLLALYIAY 307
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 491-653 9.99e-03

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 38.46  E-value: 9.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598  491 VYSYLGFLMSIAWIYTISSEIINVITMIGVATGVSQEILGLTIMAWSNCIGDIVSDVAVVKQGFPKMAMAAAIGGPLFsk 570
Cdd:TIGR00367 169 FFSLVLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIF-- 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392919598  571 lysrpcqikittyisDLLIGFGLPFTIACLQGKQIDLIitpvyrLLMLFLAI-SLFTSLIAIFVQRFKvRWpHAVALLTV 649
Cdd:TIGR00367 247 ---------------NILVGLGVPSLFMPIPVEPLAYN------LDAPVMVIvTLLLMLFFKTSMKLG-RW-EGILLLAL 303


                  ....
gi 392919598  650 FVAF 653
Cdd:TIGR00367 304 YIAY 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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