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Conserved domains on  [gi|392920498|ref|NP_001256259|]
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WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 176-470 6.29e-90

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 276.52  E-value: 6.29e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 176 LYRVASGHTGWVRAVDVEPGNQWFASGGADRIIKIWDLASGQLKLSLTGHISSVRAVKVSPRHPFLFSGGEDKQVKCWDL 255
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 256 EYNKVIRHYHGHLSAVQALSVHPSLDVLVTCARDSTARVWDMRTKAQVHCFAGHTNTVADVVCQSVDPQVITASHDATVR 335
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 336 LWDLAAGRSMCTLTHHKKSVRALTIHPRLNMFASASPDN-IKQWKLPKGEFMQNLSGHNAIINTLS-SNDDGVVVSGADN 413
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAfSPDGYLLASGSED 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 392920498 414 GSLCFWDWRSGFCFQKIQtkpqpgsiESEAGIYASCFDKTGLRLITAEADKTIKMYK 470
Cdd:cd00200  241 GTIRVWDLRTGECVQTLS--------GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 176-470 6.29e-90

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 276.52  E-value: 6.29e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 176 LYRVASGHTGWVRAVDVEPGNQWFASGGADRIIKIWDLASGQLKLSLTGHISSVRAVKVSPRHPFLFSGGEDKQVKCWDL 255
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 256 EYNKVIRHYHGHLSAVQALSVHPSLDVLVTCARDSTARVWDMRTKAQVHCFAGHTNTVADVVCQSVDPQVITASHDATVR 335
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 336 LWDLAAGRSMCTLTHHKKSVRALTIHPRLNMFASASPDN-IKQWKLPKGEFMQNLSGHNAIINTLS-SNDDGVVVSGADN 413
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAfSPDGYLLASGSED 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 392920498 414 GSLCFWDWRSGFCFQKIQtkpqpgsiESEAGIYASCFDKTGLRLITAEADKTIKMYK 470
Cdd:cd00200  241 GTIRVWDLRTGECVQTLS--------GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
109-467 2.11e-69

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 227.10  E-value: 2.11e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 109 ASAGTPLAITDGSGKLVNQQQGSAKSGTLLPLVPLGNS--SKGEDNTTRSllpskapmmmkpkWHAP-WKLYRVASGHTG 185
Cdd:COG2319   55 AGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLlaSASADGTVRL-------------WDLAtGLLLRTLTGHTG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 186 WVRAVDVEPGNQWFASGGADRIIKIWDLASGQLKLSLTGHISSVRAVKVSPRHPFLFSGGEDKQVKCWDLEYNKVIRHYH 265
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 266 GHLSAVQALSVHPSLDVLVTCARDSTARVWDMRTKAQVHCFAGHTNTVADVVCQSVDPQVITASHDATVRLWDLAAGRSM 345
Cdd:COG2319  202 GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 346 CTLTHHKKSVRALTIHPRLNMFASASPDN-IKQWKLPKGEFMQNLSGHNAIINTLS-SNDDGVVVSGADNGSLCFWDWRS 423
Cdd:COG2319  282 RTLTGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLAT 361

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 392920498 424 GFCFQKIQtkpqpgsiESEAGIYASCFDKTGLRLITAEADKTIK 467
Cdd:COG2319  362 GELLRTLT--------GHTGAVTSVAFSPDGRTLASGSADGTVR 397
WD40 pfam00400
WD domain, G-beta repeat;
174-212 7.69e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 7.69e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 392920498  174 WKLYRVASGHTGWVRAVDVEPGNQWFASGGADRIIKIWD 212
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 173-212 8.27e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 8.27e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 392920498   173 PWKLYRVASGHTGWVRAVDVEPGNQWFASGGADRIIKIWD 212
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 200-371 5.21e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.40  E-value: 5.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 200 ASGGADRIIKIWDLASGQLKLSLTGHISSVRAVKVSPRHPFLF-SGGEDKQVKCWDLEYNKVIR--HYHGHLSAVQALSv 276
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGtiKTKANICCVQFPS- 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 277 hPSLDVLVTCARDSTARVWDMRTKAQVHC-FAGHTNTVADVvcQSVDPQ-VITASHDATVRLWDLaagrSMCTLTHHKKS 354
Cdd:PLN00181 628 -ESGRSLAFGSADHKVYYYDLRNPKLPLCtMIGHSKTVSYV--RFVDSStLVSSSTDNTLKLWDL----SMSISGINETP 700

                        170
                 ....*....|....*..
gi 392920498 355 VRALTIHPRLNMFASAS 371
Cdd:PLN00181 701 LHSFMGHTNVKNFVGLS 717
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 176-470 6.29e-90

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 276.52  E-value: 6.29e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 176 LYRVASGHTGWVRAVDVEPGNQWFASGGADRIIKIWDLASGQLKLSLTGHISSVRAVKVSPRHPFLFSGGEDKQVKCWDL 255
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 256 EYNKVIRHYHGHLSAVQALSVHPSLDVLVTCARDSTARVWDMRTKAQVHCFAGHTNTVADVVCQSVDPQVITASHDATVR 335
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 336 LWDLAAGRSMCTLTHHKKSVRALTIHPRLNMFASASPDN-IKQWKLPKGEFMQNLSGHNAIINTLS-SNDDGVVVSGADN 413
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAfSPDGYLLASGSED 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 392920498 414 GSLCFWDWRSGFCFQKIQtkpqpgsiESEAGIYASCFDKTGLRLITAEADKTIKMYK 470
Cdd:cd00200  241 GTIRVWDLRTGECVQTLS--------GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
109-467 2.11e-69

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 227.10  E-value: 2.11e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 109 ASAGTPLAITDGSGKLVNQQQGSAKSGTLLPLVPLGNS--SKGEDNTTRSllpskapmmmkpkWHAP-WKLYRVASGHTG 185
Cdd:COG2319   55 AGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLlaSASADGTVRL-------------WDLAtGLLLRTLTGHTG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 186 WVRAVDVEPGNQWFASGGADRIIKIWDLASGQLKLSLTGHISSVRAVKVSPRHPFLFSGGEDKQVKCWDLEYNKVIRHYH 265
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 266 GHLSAVQALSVHPSLDVLVTCARDSTARVWDMRTKAQVHCFAGHTNTVADVVCQSVDPQVITASHDATVRLWDLAAGRSM 345
Cdd:COG2319  202 GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 346 CTLTHHKKSVRALTIHPRLNMFASASPDN-IKQWKLPKGEFMQNLSGHNAIINTLS-SNDDGVVVSGADNGSLCFWDWRS 423
Cdd:COG2319  282 RTLTGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLAT 361

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 392920498 424 GFCFQKIQtkpqpgsiESEAGIYASCFDKTGLRLITAEADKTIK 467
Cdd:COG2319  362 GELLRTLT--------GHTGAVTSVAFSPDGRTLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
170-423 6.89e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 207.46  E-value: 6.89e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 170 WHAP-WKLYRVASGHTGWVRAVDVEPGNQWFASGGADRIIKIWDLASGQLKLSLTGHISSVRAVKVSPRHPFLFSGGEDK 248
Cdd:COG2319  147 WDLAtGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADG 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 249 QVKCWDLEYNKVIRHYHGHLSAVQALSVHPSLDVLVTCARDSTARVWDMRTKAQVHCFAGHTNTVADVVCqSVDPQ-VIT 327
Cdd:COG2319  227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF-SPDGKlLAS 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 328 ASHDATVRLWDLAAGRSMCTLTHHKKSVRALTIHPRLNMFASASPDN-IKQWKLPKGEFMQNLSGHNAIINTLS-SNDDG 405
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLTGHTGAVTSVAfSPDGR 385

                        250
                 ....*....|....*...
gi 392920498 406 VVVSGADNGSLCFWDWRS 423
Cdd:COG2319  386 TLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
170-469 7.65e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 207.46  E-value: 7.65e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 170 WHAPWKLYRVASGHTGWVRAVDVEPGNQWFASGGADRIIKIWDLASGQLKLSLTGHISSVRAVKVSPRHPFLFSGGEDKQ 249
Cdd:COG2319   64 DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 250 VKCWDLEYNKVIRHYHGHLSAVQALSVHPSLDVLVTCARDSTARVWDMRTKAQVHCFAGHTNTVADVVCqSVDPQVI-TA 328
Cdd:COG2319  144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF-SPDGKLLaSG 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 329 SHDATVRLWDLAAGRSMCTLTHHKKSVRALTIHPRLNMFASASPDN-IKQWKLPKGEFMQNLSGHNAIINTLS-SNDDGV 406
Cdd:COG2319  223 SADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGtVRLWDLATGELLRTLTGHSGGVNSVAfSPDGKL 302

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392920498 407 VVSGADNGSLCFWDWRSGFCFQKIQtkpqpgsiESEAGIYASCFDKTGLRLITAEADKTIKMY 469
Cdd:COG2319  303 LASGSDDGTVRLWDLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-379 8.22e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 185.23  E-value: 8.22e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 102 HGTGSVIASAGTplaitDGSGKLVNQQQGSAK------SGTLLPLVPLGNSSK----GEDNTTRsLLPSKAPmmmkpkwh 171
Cdd:cd00200   18 SPDGKLLATGSG-----DGTIKVWDLETGELLrtlkghTGPVRDVAASADGTYlasgSSDKTIR-LWDLETG-------- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 172 apwKLYRVASGHTGWVRAVDVEPGNQWFASGGADRIIKIWDLASGQLKLSLTGHISSVRAVKVSPRHPFLFSGGEDKQVK 251
Cdd:cd00200   84 ---ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 252 CWDLEYNKVIRHYHGHLSAVQALSVHPSLDVLVTCARDSTARVWDMRTKAQVHCFAGHTNTVADVVcqsVDPQ---VITA 328
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA---FSPDgylLASG 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 392920498 329 SHDATVRLWDLAAGRSMCTLTHHKKSVRALTIHPRLNMFASASPDN-IKQWK 379
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGtIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
178-469 7.75e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 183.57  E-value: 7.75e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 178 RVASGHTGWVRAVDVEPGNQWFASGGADRIIKIWDLASGQLKLSLTGHISSVRAVKVSPRHPFLFSGGEDKQVKCWDLEY 257
Cdd:COG2319   30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 258 NKVIRHYHGHLSAVQALSVHPSLDVLVTCARDSTARVWDMRTKAQVHCFAGHTNTVADVvcqSVDP---QVITASHDATV 334
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSV---AFSPdgkLLASGSDDGTV 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 335 RLWDLAAGRSMCTLTHHKKSVRALTIHPRLNMFASASPDN-IKQWKLPKGEFMQNLSGHNAIINTLS-SNDDGVVVSGAD 412
Cdd:COG2319  187 RLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGtVRLWDLATGKLLRTLTGHSGSVRSVAfSPDGRLLASGSA 266

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 392920498 413 NGSLCFWDWRSGfcfQKIQTKPQPGSieseaGIYASCFDKTGLRLITAEADKTIKMY 469
Cdd:COG2319  267 DGTVRLWDLATG---ELLRTLTGHSG-----GVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
191-469 1.00e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.83  E-value: 1.00e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 191 DVEPGNQWFASGGADRIIKIWDLASGQLKLSLTGHISSVRAVKVSPRHPFLFSGGEDKQVKCWDLEYNKVIRHYHGHLSA 270
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 271 VQALSVHPSLDVLVTCARDSTARVWDMRTKAQVHCFAGHTNTVADVVCQSVDPQVITASHDATVRLWDLAAGRSMCTLTH 350
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 351 HKKSVRALTIHPRLNMFASASPDN-IKQWKLPKGEFMQNLSGHNAIINTLSSNDDG-VVVSGADNGSLCFWDWRSGFCFQ 428
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLLR 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 392920498 429 KIQTkpqpgsieSEAGIYASCFDKTGLRLITAEADKTIKMY 469
Cdd:COG2319  241 TLTG--------HSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 pfam00400
WD domain, G-beta repeat;
174-212 7.69e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 7.69e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 392920498  174 WKLYRVASGHTGWVRAVDVEPGNQWFASGGADRIIKIWD 212
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 173-212 8.27e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 8.27e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 392920498   173 PWKLYRVASGHTGWVRAVDVEPGNQWFASGGADRIIKIWD 212
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 215-254 2.08e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 2.08e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 392920498   215 SGQLKLSLTGHISSVRAVKVSPRHPFLFSGGEDKQVKCWD 254
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 200-371 5.21e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.40  E-value: 5.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 200 ASGGADRIIKIWDLASGQLKLSLTGHISSVRAVKVSPRHPFLF-SGGEDKQVKCWDLEYNKVIR--HYHGHLSAVQALSv 276
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGtiKTKANICCVQFPS- 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 277 hPSLDVLVTCARDSTARVWDMRTKAQVHC-FAGHTNTVADVvcQSVDPQ-VITASHDATVRLWDLaagrSMCTLTHHKKS 354
Cdd:PLN00181 628 -ESGRSLAFGSADHKVYYYDLRNPKLPLCtMIGHSKTVSYV--RFVDSStLVSSSTDNTLKLWDL----SMSISGINETP 700

                        170
                 ....*....|....*..
gi 392920498 355 VRALTIHPRLNMFASAS 371
Cdd:PLN00181 701 LHSFMGHTNVKNFVGLS 717
WD40 pfam00400
WD domain, G-beta repeat;
216-254 6.02e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 6.02e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 392920498  216 GQLKLSLTGHISSVRAVKVSPRHPFLFSGGEDKQVKCWD 254
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 259-296 1.94e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.94e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 392920498   259 KVIRHYHGHLSAVQALSVHPSLDVLVTCARDSTARVWD 296
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
258-296 6.99e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 6.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 392920498  258 NKVIRHYHGHLSAVQALSVHPSLDVLVTCARDSTARVWD 296
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 299-338 1.91e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.91e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 392920498   299 TKAQVHCFAGHTNTVADVVCQSVDPQVITASHDATVRLWD 338
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
302-338 2.16e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.16e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 392920498  302 QVHCFAGHTNTVADVVCQSVDPQVITASHDATVRLWD 338
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 315-424 3.81e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 42.75  E-value: 3.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498  315 DVV-CQSVDPQ---VITASHDATVRLWDLAAGRSMctlthHKKSVRALTIHPRLNMFASASPDNIkqwklpkgefmqnLS 390
Cdd:pfam20426 125 DVVsCVAVTSDgsiLATGSYDTTVMVWEVLRGRSS-----EKRSRNTQTEFPRKDHVIAETPFHI-------------LC 186

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 392920498  391 GHNAIINTL-SSNDDGVVVSGADNGSLCFWDWRSG 424
Cdd:pfam20426 187 GHDDIITCLyVSVELDIVISGSKDGTCIFHTLREG 221
PTZ00421 PTZ00421
coronin; Provisional
 239-358 5.18e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 5.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392920498 239 PF----LFSGGEDKQVKCWDLEYNKV-------IRHYHGHLSAVQALSVHPS-LDVLVTCARDSTARVWDMRTKAQVHCF 306
Cdd:PTZ00421  85 PFdpqkLFTASEDGTIMGWGIPEEGLtqnisdpIVHLQGHTKKVGIVSFHPSaMNVLASAGADMVVNVWDVERGKAVEVI 164

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 392920498 307 AGHTNTVADVVCQSVDPQVITASHDATVRLWDLAAGRSMCTLTHHK--KSVRAL 358
Cdd:PTZ00421 165 KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHAsaKSQRCL 218
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 382-420 1.35e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.35e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 392920498   382 KGEFMQNLSGHNAIINTLSSNDDG-VVVSGADNGSLCFWD 420
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 342-379 1.57e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.57e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 392920498   342 GRSMCTLTHHKKSVRALTIHPRLNMFASASPDN-IKQWK 379
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGtIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
383-420 1.72e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 392920498  383 GEFMQNLSGHNAIINTLSSNDDG-VVVSGADNGSLCFWD 420
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
342-378 9.00e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 9.00e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 392920498  342 GRSMCTLTHHKKSVRALTIHPRLNMFASASPDN-IKQW 378
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGtVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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