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Conserved domains on  [gi|392922220|ref|NP_001256679|]
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Kelch domain-containing protein 10 [Caenorhabditis elegans]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 1015026)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
2-94 4.74e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 70.96  E-value: 4.74e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922220   2 ALNLATGAWTRTKvpenTMkPGGRRSHS-TWVYDGKMYMFGGYLGTINV--HYNELYCFDPKTSMWSVIsvrGTYPSARR 78
Cdd:COG3055   42 VYDPATNTWSELA----PL-PGPPRHHAaAVAQDGKLYVFGGFTGANPSstPLNDVYVYDPATNTWTKL---APMPTPRG 113

                         90
                 ....*....|....*.
gi 392922220  79 RHCSVVSNGKVYLFGG 94
Cdd:COG3055  114 GATALLLDGKIYVVGG 129
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
2-94 4.74e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 70.96  E-value: 4.74e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922220   2 ALNLATGAWTRTKvpenTMkPGGRRSHS-TWVYDGKMYMFGGYLGTINV--HYNELYCFDPKTSMWSVIsvrGTYPSARR 78
Cdd:COG3055   42 VYDPATNTWSELA----PL-PGPPRHHAaAVAQDGKLYVFGGFTGANPSstPLNDVYVYDPATNTWTKL---APMPTPRG 113

                         90
                 ....*....|....*.
gi 392922220  79 RHCSVVSNGKVYLFGG 94
Cdd:COG3055  114 GATALLLDGKIYVVGG 129
PLN02153 PLN02153
epithiospecifier protein
 22-94 4.04e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 48.83  E-value: 4.04e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392922220  22 PGGRRSHSTWVYDGKMYMFGGYLgTINVHYN-ELYCFDPKTSMWSVISVRGTYPSARRRHCSVVSNG-KVYLFGG 94
Cdd:PLN02153  20 PGPRCSHGIAVVGDKLYSFGGEL-KPNEHIDkDLYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGtKLYIFGG 93
Kelch_3 pfam13415
Galactose oxidase, central domain;
34-84 1.78e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 40.35  E-value: 1.78e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 392922220   34 DGKMYMFGGYLGTINVHYNELYCFDPKTSMWSVIsvrGTYPSARRRHCSVV 84
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATY 48
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
2-94 4.74e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 70.96  E-value: 4.74e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922220   2 ALNLATGAWTRTKvpenTMkPGGRRSHS-TWVYDGKMYMFGGYLGTINV--HYNELYCFDPKTSMWSVIsvrGTYPSARR 78
Cdd:COG3055   42 VYDPATNTWSELA----PL-PGPPRHHAaAVAQDGKLYVFGGFTGANPSstPLNDVYVYDPATNTWTKL---APMPTPRG 113

                         90
                 ....*....|....*.
gi 392922220  79 RHCSVVSNGKVYLFGG 94
Cdd:COG3055  114 GATALLLDGKIYVVGG 129
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
4-129 5.12e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 65.56  E-value: 5.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922220   4 NLATGAWTRTkvpeNTMkPGGRRSHSTWVYDGKMYMFGGYLGTINVHYNELYcfDPKTSMWSVIsvrGTYPSARRRHCSV 83
Cdd:COG3055   96 DPATNTWTKL----APM-PTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVY--DPATGTWTQL---APLPTPRDHLAAA 165

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392922220  84 V-SNGKVYLFGG--------------TMPLPCHPLSTTNYNGMISPSGLAD--LSDLHVLDFA 129
Cdd:COG3055  166 VlPDGKILVIGGrngsgfsntwttlaPLPTARAGHAAAVLGGKILVFGGESgfSDEVEAYDPA 228
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
6-94 1.15e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 59.01  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922220   6 ATGAWTRTKVPentmkPGGRRSHSTWVYDGKMYMFGGYLGTinvhYNELYCFDPKTSMWSVIsvrGTYPSARRRHCSVVS 85
Cdd:COG3055  183 FSNTWTTLAPL-----PTARAGHAAAVLGGKILVFGGESGF----SDEVEAYDPATNTWTAL---GELPTPRHGHAAVLT 250


                 ....*....
gi 392922220  86 NGKVYLFGG 94
Cdd:COG3055  251 DGKVYVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
22-94 2.32e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 57.86  E-value: 2.32e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392922220  22 PGGRRSHSTWVYDGKMYMFGGYLGTinVHYNELYCFDPKTSMWSVIsvrGTYPSARRRH-CSVVSNGKVYLFGG 94
Cdd:COG3055   10 PTPRSEAAAALLDGKVYVAGGLSGG--SASNSFEVYDPATNTWSEL---APLPGPPRHHaAAVAQDGKLYVFGG 78
PLN02153 PLN02153
epithiospecifier protein
 22-94 4.04e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 48.83  E-value: 4.04e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392922220  22 PGGRRSHSTWVYDGKMYMFGGYLgTINVHYN-ELYCFDPKTSMWSVISVRGTYPSARRRHCSVVSNG-KVYLFGG 94
Cdd:PLN02153  20 PGPRCSHGIAVVGDKLYSFGGEL-KPNEHIDkDLYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGtKLYIFGG 93
PLN02193 PLN02193
nitrile-specifier protein
 8-113 2.08e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 46.87  E-value: 2.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922220   8 GAWTrtKVPENTMKPGGRRSHSTWVYDGKMYMFGGYL---GTINVHyneLYCFDPKTSMWSVISVRGTYPSARRRHCSVV 84
Cdd:PLN02193 151 GKWI--KVEQKGEGPGLRCSHGIAQVGNKIYSFGGEFtpnQPIDKH---LYVFDLETRTWSISPATGDVPHLSCLGVRMV 225

                         90       100       110
                 ....*....|....*....|....*....|
gi 392922220  85 SNGK-VYLFGGTMplpchplSTTNYNGMIS 113
Cdd:PLN02193 226 SIGStLYVFGGRD-------ASRQYNGFYS 248
PRK14131 PRK14131
N-acetylneuraminate epimerase;
22-94 9.00e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 45.01  E-value: 9.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922220  22 PGGRRSHSTWVY-DGKMYMFGGyLGTIN-----VHYNELYCFDPKTSMWSVISVRGtyPSARRRHCSVVSNG-KVYLFGG 94
Cdd:PRK14131  71 PGGPREQAVAAFiDGKLYVFGG-IGKTNsegspQVFDDVYKYDPKTNSWQKLDTRS--PVGLAGHVAVSLHNgKAYITGG 147
Kelch_3 pfam13415
Galactose oxidase, central domain;
34-84 1.78e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 40.35  E-value: 1.78e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 392922220   34 DGKMYMFGGYLGTINVHYNELYCFDPKTSMWSVIsvrGTYPSARRRHCSVV 84
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATY 48
PLN02153 PLN02153
epithiospecifier protein
 2-94 1.19e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 41.51  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922220   2 ALNLATGAWTRTKVP-ENTMKPGGRrshSTWVYDGKMYMFGGYLGTI------NVHYNELYCFDPKTSMWSVISVRGTYP 74
Cdd:PLN02153 163 AYNIADGKWVQLPDPgENFEKRGGA---GFAVVQGKIWVVYGFATSIlpggksDYESNAVQFFDPASGKWTEVETTGAKP 239

                         90       100
                 ....*....|....*....|
gi 392922220  75 SARRRHCSVVSNGKVYLFGG 94
Cdd:PLN02153 240 SARSVFAHAVVGKYIIIFGG 259
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 22-61 2.70e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 2.70e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 392922220   22 PGGRRSHSTWVYDGKMYMFGGYLGTINVHYNELYCFDPKT 61
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQPSDDVYVLSLPT 40
Kelch_6 pfam13964
Kelch motif;
25-68 6.82e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.16  E-value: 6.82e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 392922220   25 RRSHSTWVYDGKMYMFGGYlGTINVHYNELYCFDPKTSMWSVIS 68
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGY-TNASPALNKLEVYNPLTKSWEELP 44
PLN02193 PLN02193
nitrile-specifier protein
 37-94 1.00e-03

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 39.17  E-value: 1.00e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 392922220  37 MYMFGGYlgTINVHYNELYCFDPKTSMWSVISVRGTYPSARRRHCSVVSNGKVYLFGG 94
Cdd:PLN02193 231 LYVFGGR--DASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGG 286
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 74-94 3.92e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 34.08  E-value: 3.92e-03
                          10        20
                  ....*....|....*....|.
gi 392922220   74 PSARRRHCSVVSNGKVYLFGG 94
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGG 21
PHA03098 PHA03098
kelch-like protein; Provisional
 28-96 3.99e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 37.05  E-value: 3.99e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922220  28 HSTWVYDGKMYMFGGYLGTINVH-YNELYCFDPKTSMWSVISVRgTYPSARRRHCSVvsNGKVYLFGGTM 96
Cdd:PHA03098 431 GCAIYHDGKIYVIGGISYIDNIKvYNIVESYNPVTNKWTELSSL-NFPRINASLCIF--NNKIYVVGGDK 497
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 25-68 8.30e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 32.97  E-value: 8.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 392922220   25 RRSHSTWVYDGKMYMFGGYLGtiNVHYNELYCFDPKTSMWSVIS 68
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDG--NQSLNSVEVYDPETNTWSKLP 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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