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Conserved domains on  [gi|392922682|ref|NP_001256784|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box protein( domain architecture ID 18324792)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins; similar to Caenorhabditis elegans F-box domain-containing protein

Gene Ontology:  GO:0000209|GO:0031146|GO:0019005|GO:0005515
PubMed:  10581972|31898225

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 243-377 1.46e-41

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 143.48  E-value: 1.46e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922682  243 ENFASILKSCSPIHAKQVRVEYPDLAfDASKILSLFQPKALTNIKL-KCSNLADISAIFELEQWKNAKSVEINSFTKF-- 319
Cdd:pfam01827   5 ESFLNILKSKKCLHVKEISLSGLSFS-EVASILPYFDAGTLEEIELsSESDEDQFEEIVELEQWKNAKSLKIEGSSLSsf 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 392922682  320 PIGNLFHLSQFSVKLESFSVDDAIKIRDILLKSPSFQSGKFTSYSSNFQEMLKVFVPR 377
Cdd:pfam01827  84 PIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 83-128 1.73e-12

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438921  Cd Length: 46  Bit Score: 61.35  E-value: 1.73e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 392922682  83 LGDMPNEILVKIMDIQDPINRIVIRKVSQRFRSLFDVMDPGFKSFK 128
Cdd:cd22150    1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
HTH_48 pfam17906
HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase ...
 18-61 7.11e-11

HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase comprises two HTH domains. This HTH domain binds in the DNA major groove to the transposons inverted repeats.


:

Pssm-ID: 465558 [Multi-domain]  Cd Length: 50  Bit Score: 57.14  E-value: 7.11e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 392922682   18 KIALRACISYEYLIGKSSFEAYKSFCKQMGDDIMEYGEFDFWFY 61
Cdd:pfam17906   1 KIHLRHCILYEFLQGKSAAEAYRNICEVYGEDAVSERTFQRWFA 44
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 243-377 1.46e-41

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 143.48  E-value: 1.46e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922682  243 ENFASILKSCSPIHAKQVRVEYPDLAfDASKILSLFQPKALTNIKL-KCSNLADISAIFELEQWKNAKSVEINSFTKF-- 319
Cdd:pfam01827   5 ESFLNILKSKKCLHVKEISLSGLSFS-EVASILPYFDAGTLEEIELsSESDEDQFEEIVELEQWKNAKSLKIEGSSLSsf 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 392922682  320 PIGNLFHLSQFSVKLESFSVDDAIKIRDILLKSPSFQSGKFTSYSSNFQEMLKVFVPR 377
Cdd:pfam01827  84 PIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 83-128 1.73e-12

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 61.35  E-value: 1.73e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 392922682  83 LGDMPNEILVKIMDIQDPINRIVIRKVSQRFRSLFDVMDPGFKSFK 128
Cdd:cd22150    1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
HTH_48 pfam17906
HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase ...
 18-61 7.11e-11

HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase comprises two HTH domains. This HTH domain binds in the DNA major groove to the transposons inverted repeats.


Pssm-ID: 465558 [Multi-domain]  Cd Length: 50  Bit Score: 57.14  E-value: 7.11e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 392922682   18 KIALRACISYEYLIGKSSFEAYKSFCKQMGDDIMEYGEFDFWFY 61
Cdd:pfam17906   1 KIHLRHCILYEFLQGKSAAEAYRNICEVYGEDAVSERTFQRWFA 44
FBOX smart00256
A Receptor for Ubiquitination Targets;
86-126 3.47e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 43.58  E-value: 3.47e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 392922682    86 MPNEILVKIMDIQDPINRIVIRKVSQRFRSLFDVMDPGFKS 126
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 85-125 5.93e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 37.13  E-value: 5.93e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 392922682   85 DMPNEILVKIMDIQDPINRIVIRKVSQRFRSLFDVMDPGFK 125
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 243-377 1.46e-41

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 143.48  E-value: 1.46e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392922682  243 ENFASILKSCSPIHAKQVRVEYPDLAfDASKILSLFQPKALTNIKL-KCSNLADISAIFELEQWKNAKSVEINSFTKF-- 319
Cdd:pfam01827   5 ESFLNILKSKKCLHVKEISLSGLSFS-EVASILPYFDAGTLEEIELsSESDEDQFEEIVELEQWKNAKSLKIEGSSLSsf 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 392922682  320 PIGNLFHLSQFSVKLESFSVDDAIKIRDILLKSPSFQSGKFTSYSSNFQEMLKVFVPR 377
Cdd:pfam01827  84 PIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 83-128 1.73e-12

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 61.35  E-value: 1.73e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 392922682  83 LGDMPNEILVKIMDIQDPINRIVIRKVSQRFRSLFDVMDPGFKSFK 128
Cdd:cd22150    1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
HTH_48 pfam17906
HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase ...
 18-61 7.11e-11

HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase comprises two HTH domains. This HTH domain binds in the DNA major groove to the transposons inverted repeats.


Pssm-ID: 465558 [Multi-domain]  Cd Length: 50  Bit Score: 57.14  E-value: 7.11e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 392922682   18 KIALRACISYEYLIGKSSFEAYKSFCKQMGDDIMEYGEFDFWFY 61
Cdd:pfam17906   1 KIHLRHCILYEFLQGKSAAEAYRNICEVYGEDAVSERTFQRWFA 44
FBOX smart00256
A Receptor for Ubiquitination Targets;
86-126 3.47e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 43.58  E-value: 3.47e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 392922682    86 MPNEILVKIMDIQDPINRIVIRKVSQRFRSLFDVMDPGFKS 126
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 85-125 5.93e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 37.13  E-value: 5.93e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 392922682   85 DMPNEILVKIMDIQDPINRIVIRKVSQRFRSLFDVMDPGFK 125
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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