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Conserved domains on  [gi|392927061|ref|NP_001257100|]
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Cuticlin-5 [Caenorhabditis elegans]

Protein Classification

zona pellucida domain-containing protein( domain architecture ID 1903244)

zona pellucida (ZP) domain-containing protein may function as a structural component of egg coats, appendicularian mucous houses, and nematode dauer larvae, or as a mechanotransducer in flies, or as a receptor in mammals and nonmammals

Gene Ontology:  GO:0031012

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ZP super family cl42957
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
53-290 1.94e-46

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


The actual alignment was detected with superfamily member smart00241:

Pssm-ID: 214579  Cd Length: 252  Bit Score: 159.47  E-value: 1.94e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392927061    53 IKVKFDTRTTFHGLAFVQN-HLDNPDCRSFASKTDSAKNSsLRLTFDQCAIekRHSTSPRGLFLSTNVVVA-FNPEFLTK 130
Cdd:smart00241   7 MVVSVSTDLLFPGGINVKGlTLGDPSCRPQFTDATSAFVS-FEVPLNGCGT--RRQVNPDGIVYSNTLVVSpFHPGFITR 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392927061   131 NDRV-FKVQCFYMEMERRIQKVIQISMPPPTMHSKQLNMPVCKYEVLDGSPTGPPVYFAT--VGQMVYHKWTCDTEHENT 207
Cdd:smart00241  84 DDRAaYHFQCFYPENEKVSLNLDVSTIPPTELSSVSEGPLTCSYRLYKDDSFGSPYQSADyvLGDPVYHEWECDGADDPP 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392927061   208 FCMLVHSCFVDDGN----GQRVQLLnDKGCALDKYLLTNLEYPTD--LMAGREAHVYKYADRDNMYFDCQISITVKEPGL 281
Cdd:smart00241 164 LGLLVDNCYATPGPdpssGPKYFII-DNGCPVDGYLDSTIPYNSNplHRARFSVKVFKFADRSLVYFHCQIRLCDKDDGS 242

                   ....*....
gi 392927061   282 DyCDVPSCP 290
Cdd:smart00241 243 S-CDGPACS 250
 
Name Accession Description Interval E-value
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
53-290 1.94e-46

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 159.47  E-value: 1.94e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392927061    53 IKVKFDTRTTFHGLAFVQN-HLDNPDCRSFASKTDSAKNSsLRLTFDQCAIekRHSTSPRGLFLSTNVVVA-FNPEFLTK 130
Cdd:smart00241   7 MVVSVSTDLLFPGGINVKGlTLGDPSCRPQFTDATSAFVS-FEVPLNGCGT--RRQVNPDGIVYSNTLVVSpFHPGFITR 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392927061   131 NDRV-FKVQCFYMEMERRIQKVIQISMPPPTMHSKQLNMPVCKYEVLDGSPTGPPVYFAT--VGQMVYHKWTCDTEHENT 207
Cdd:smart00241  84 DDRAaYHFQCFYPENEKVSLNLDVSTIPPTELSSVSEGPLTCSYRLYKDDSFGSPYQSADyvLGDPVYHEWECDGADDPP 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392927061   208 FCMLVHSCFVDDGN----GQRVQLLnDKGCALDKYLLTNLEYPTD--LMAGREAHVYKYADRDNMYFDCQISITVKEPGL 281
Cdd:smart00241 164 LGLLVDNCYATPGPdpssGPKYFII-DNGCPVDGYLDSTIPYNSNplHRARFSVKVFKFADRSLVYFHCQIRLCDKDDGS 242

                   ....*....
gi 392927061   282 DyCDVPSCP 290
Cdd:smart00241 243 S-CDGPACS 250
 
Name Accession Description Interval E-value
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
53-290 1.94e-46

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 159.47  E-value: 1.94e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392927061    53 IKVKFDTRTTFHGLAFVQN-HLDNPDCRSFASKTDSAKNSsLRLTFDQCAIekRHSTSPRGLFLSTNVVVA-FNPEFLTK 130
Cdd:smart00241   7 MVVSVSTDLLFPGGINVKGlTLGDPSCRPQFTDATSAFVS-FEVPLNGCGT--RRQVNPDGIVYSNTLVVSpFHPGFITR 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392927061   131 NDRV-FKVQCFYMEMERRIQKVIQISMPPPTMHSKQLNMPVCKYEVLDGSPTGPPVYFAT--VGQMVYHKWTCDTEHENT 207
Cdd:smart00241  84 DDRAaYHFQCFYPENEKVSLNLDVSTIPPTELSSVSEGPLTCSYRLYKDDSFGSPYQSADyvLGDPVYHEWECDGADDPP 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392927061   208 FCMLVHSCFVDDGN----GQRVQLLnDKGCALDKYLLTNLEYPTD--LMAGREAHVYKYADRDNMYFDCQISITVKEPGL 281
Cdd:smart00241 164 LGLLVDNCYATPGPdpssGPKYFII-DNGCPVDGYLDSTIPYNSNplHRARFSVKVFKFADRSLVYFHCQIRLCDKDDGS 242

                   ....*....
gi 392927061   282 DyCDVPSCP 290
Cdd:smart00241 243 S-CDGPACS 250
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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