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Conserved domains on  [gi|402534539|ref|NP_001257980|]
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augurin precursor [Rattus norvegicus]

Protein Classification

Augurin domain-containing protein( domain architecture ID 10633552)

Augurin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Augurin pfam15187
Oesophageal cancer-related gene 4; Augurin is alternatively named oesophageal cancer-related ...
 32-148 2.29e-58

Oesophageal cancer-related gene 4; Augurin is alternatively named oesophageal cancer-related gene 4 protein. The function of this family of transmembrane proteins, is to induce the senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation. Augurin has been found to stimulate the release of ACTH via the release of hypothalamic CRF. This family of proteins is found in eukaryotes. Proteins in this family are typically 145 amino acids in length.


:

Pssm-ID: 464552  Cd Length: 115  Bit Score: 176.91  E-value: 2.29e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402534539   32 NKLKKMLQKRE--GPVPSKTNVAVSEHTAKEFLGGLKRAKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDVNYWLNRnQ 109
Cdd:pfam15187   1 NKLHLILQKREvaGSAPSKASVAVPESKAKEFLASLKRTKRNLWDRSRPDVQQWIQQFMYMGFDEQRLEDDLSYWMDQ-A 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 402534539  110 NGHDYygdYYQRHYDEDAAIGPRSREGFRHGASVNYDDY 148
Cdd:pfam15187  80 RSHDQ---GRQHHYDENAPIGPRDPSSFRHGANVNYDDY 115
 
Name Accession Description Interval E-value
Augurin pfam15187
Oesophageal cancer-related gene 4; Augurin is alternatively named oesophageal cancer-related ...
 32-148 2.29e-58

Oesophageal cancer-related gene 4; Augurin is alternatively named oesophageal cancer-related gene 4 protein. The function of this family of transmembrane proteins, is to induce the senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation. Augurin has been found to stimulate the release of ACTH via the release of hypothalamic CRF. This family of proteins is found in eukaryotes. Proteins in this family are typically 145 amino acids in length.


Pssm-ID: 464552  Cd Length: 115  Bit Score: 176.91  E-value: 2.29e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402534539   32 NKLKKMLQKRE--GPVPSKTNVAVSEHTAKEFLGGLKRAKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDVNYWLNRnQ 109
Cdd:pfam15187   1 NKLHLILQKREvaGSAPSKASVAVPESKAKEFLASLKRTKRNLWDRSRPDVQQWIQQFMYMGFDEQRLEDDLSYWMDQ-A 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 402534539  110 NGHDYygdYYQRHYDEDAAIGPRSREGFRHGASVNYDDY 148
Cdd:pfam15187  80 RSHDQ---GRQHHYDENAPIGPRDPSSFRHGANVNYDDY 115
 
Name Accession Description Interval E-value
Augurin pfam15187
Oesophageal cancer-related gene 4; Augurin is alternatively named oesophageal cancer-related ...
 32-148 2.29e-58

Oesophageal cancer-related gene 4; Augurin is alternatively named oesophageal cancer-related gene 4 protein. The function of this family of transmembrane proteins, is to induce the senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation. Augurin has been found to stimulate the release of ACTH via the release of hypothalamic CRF. This family of proteins is found in eukaryotes. Proteins in this family are typically 145 amino acids in length.


Pssm-ID: 464552  Cd Length: 115  Bit Score: 176.91  E-value: 2.29e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402534539   32 NKLKKMLQKRE--GPVPSKTNVAVSEHTAKEFLGGLKRAKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDVNYWLNRnQ 109
Cdd:pfam15187   1 NKLHLILQKREvaGSAPSKASVAVPESKAKEFLASLKRTKRNLWDRSRPDVQQWIQQFMYMGFDEQRLEDDLSYWMDQ-A 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 402534539  110 NGHDYygdYYQRHYDEDAAIGPRSREGFRHGASVNYDDY 148
Cdd:pfam15187  80 RSHDQ---GRQHHYDENAPIGPRDPSSFRHGANVNYDDY 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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