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Conserved domains on  [gi|411147371|ref|NP_001258629|]
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ankyrin repeat domain-containing protein 61 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 12356329)

ankyrin repeat (ANK) domain-containing protein mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

CATH:  1.25.40.20
Gene Ontology:  GO:0005515
PubMed:  33435370|15152081|17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
149-335 7.04e-32

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 122.76  E-value: 7.04e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 149 LRILCAHGAQVNTQGEisNKRSPLHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAANMLNKEMMETLIAYGANVN 228
Cdd:COG0666   70 ALLLLAAGADINAKDD--GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVN 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 229 cAVSSTGNTPLKLAVctassKAGRLlgagvSCIRLLLTHGAKVNAQDYKGQTAIHEACFGGREAIINLLLEFEANVNILT 308
Cdd:COG0666  148 -AQDNDGNTPLHLAA-----ANGNL-----EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD 216

                        170       180
                 ....*....|....*....|....*..
gi 411147371 309 RNGESPIYMYLQRSCNVRDTALLARLL 335
Cdd:COG0666  217 NDGKTALDLAAENGNLEIVKLLLEAGA 243
Ank_2 pfam12796
Ankyrin repeats (3 copies);
80-198 5.10e-09

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.20  E-value: 5.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371   80 IHLAAKYHKAQSLLCLLRHGADPEVRDTTGLTTLnlmllhwpvtstTWAkpgnrthriltdIQNSSITCLRILCAHGAQV 159
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTAL------------HLA------------AKNGHLEIVKLLLEHADVN 56

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 411147371  160 NTqgeiSNKRSPLHLAIAYGCYPVLSILTQNGADVNAIN 198
Cdd:pfam12796  57 LK----DNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
149-335 7.04e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 122.76  E-value: 7.04e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 149 LRILCAHGAQVNTQGEisNKRSPLHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAANMLNKEMMETLIAYGANVN 228
Cdd:COG0666   70 ALLLLAAGADINAKDD--GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVN 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 229 cAVSSTGNTPLKLAVctassKAGRLlgagvSCIRLLLTHGAKVNAQDYKGQTAIHEACFGGREAIINLLLEFEANVNILT 308
Cdd:COG0666  148 -AQDNDGNTPLHLAA-----ANGNL-----EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD 216

                        170       180
                 ....*....|....*....|....*..
gi 411147371 309 RNGESPIYMYLQRSCNVRDTALLARLL 335
Cdd:COG0666  217 NDGKTALDLAAENGNLEIVKLLLEAGA 243
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 140-323 6.53e-21

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 94.56  E-value: 6.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 140 DIQNSSITclRILCAHGAQVNTQGEISNKrSPLHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAANMLNKEMMET 219
Cdd:PHA02878 143 DIIEAEIT--KLLLSYGADINMKDRHKGN-TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHI 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 220 LIAYGANVNcAVSSTGNTPLKLAVctasskaGRLLgaGVSCIRLLLTHGAKVNAQDY-KGQTAIHEACFGgrEAIINLLL 298
Cdd:PHA02878 220 LLENGASTD-ARDKCGNTPLHISV-------GYCK--DYDILKLLLEHGVDVNAKSYiLGLTALHSSIKS--ERKLKLLL 287

                        170       180
                 ....*....|....*....|....*.
gi 411147371 299 EFEANVNILTRNGESPIYM-YLQRSC 323
Cdd:PHA02878 288 EYGADINSLNSYKLTPLSSaVKQYLC 313
Ank_2 pfam12796
Ankyrin repeats (3 copies);
172-275 4.20e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 4.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  172 LHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAANMLNKEMMETLIAYgANVNCAVSstGNTPLKLAVctassKAG 251
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN--GRTALHYAA-----RSG 72

                          90       100
                  ....*....|....*....|....
gi 411147371  252 RLlgagvSCIRLLLTHGAKVNAQD 275
Cdd:pfam12796  73 HL-----EIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
80-198 5.10e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.20  E-value: 5.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371   80 IHLAAKYHKAQSLLCLLRHGADPEVRDTTGLTTLnlmllhwpvtstTWAkpgnrthriltdIQNSSITCLRILCAHGAQV 159
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTAL------------HLA------------AKNGHLEIVKLLLEHADVN 56

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 411147371  160 NTqgeiSNKRSPLHLAIAYGCYPVLSILTQNGADVNAIN 198
Cdd:pfam12796  57 LK----DNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 79-208 8.25e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.12  E-value: 8.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  79 PIHLAAKYHKAQSLLCLLRHGADPEVRDTTGLTTlnlmlLHWPVTSTTwakpgnrthriltdiqnsSITCLRILCAHGAQ 158
Cdd:PHA02878 204 PLHHAVKHYNKPIVHILLENGASTDARDKCGNTP-----LHISVGYCK------------------DYDILKLLLEHGVD 260

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 411147371 159 VNTQGEISNkRSPLHLAIAygCYPVLSILTQNGADVNAINEASMTPLHMA 208
Cdd:PHA02878 261 VNAKSYILG-LTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSSA 307
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 172-283 1.89e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.01  E-value: 1.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 172 LHLAIAYGCYPVLSILTQNGADVnaINEA-------SMTPLHMAANMLNKEMMETLIAYGANVNCA-VSST--------- 234
Cdd:cd22192   55 LHVAALYDNLEAAVVLMEAAPEL--VNEPmtsdlyqGETALHIAVVNQNLNLVRELIARGADVVSPrATGTffrpgpknl 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 411147371 235 ---GNTPLKLAVCTASSKAgrllgagvscIRLLLTHGAKVNAQDYKGQTAIH 283
Cdd:cd22192  133 iyyGEHPLSFAACVGNEEI----------VRLLIEHGADIRAQDSLGNTVLH 174
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 170-372 6.86e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.99  E-value: 6.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  170 SPLHLAIAYGCYPVLSILTQNGADVNAineasmtplhmAANmlNKEMMETliaygANVNCAvsSTGNTPLKLAVCTASSk 249
Cdd:TIGR00870 130 TALHLAAHRQNYEIVKLLLERGASVPA-----------RAC--GDFFVKS-----QGVDSF--YHGESPLNAAACLGSP- 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  250 agrllgagvSCIRLLLTHGAKVNAQDYKGQTAIHeacfggreaIINLLLEFEANvniltrngespiymYLQRSCNVRDTA 329
Cdd:TIGR00870 189 ---------SIVALLSEDPADILTADSLGNTLLH---------LLVMENEFKAE--------------YEELSCQMYNFA 236

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 411147371  330 LlaRLLYHTYPLR----MTNNQGILPAGIMLPEFR--LLRDTL-IKQSQK 372
Cdd:TIGR00870 237 L--SLLDKLRDSKelevILNHQGLTPLKLAAKEGRivLFRLKLaIKYKQK 284
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 202-229 7.87e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 7.87e-04
                           10        20
                   ....*....|....*....|....*...
gi 411147371   202 MTPLHMAANMLNKEMMETLIAYGANVNC 229
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
149-335 7.04e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 122.76  E-value: 7.04e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 149 LRILCAHGAQVNTQGEisNKRSPLHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAANMLNKEMMETLIAYGANVN 228
Cdd:COG0666   70 ALLLLAAGADINAKDD--GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVN 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 229 cAVSSTGNTPLKLAVctassKAGRLlgagvSCIRLLLTHGAKVNAQDYKGQTAIHEACFGGREAIINLLLEFEANVNILT 308
Cdd:COG0666  148 -AQDNDGNTPLHLAA-----ANGNL-----EIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKD 216

                        170       180
                 ....*....|....*....|....*..
gi 411147371 309 RNGESPIYMYLQRSCNVRDTALLARLL 335
Cdd:COG0666  217 NDGKTALDLAAENGNLEIVKLLLEAGA 243
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
26-335 8.55e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 122.37  E-value: 8.55e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  26 AALHSKLYEAIMREDCTTIEVLLRNHPVNQPITILPNSASNRLLLTQPTESIIPIHLAAKYHKAQSLLCLLRHGADPEVR 105
Cdd:COG0666    4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 106 DTTGLTTLNLMllhwpvtsttwakpgnrthriltdIQNSSITCLRILCAHGAQVNTQGEisNKRSPLHLAIAYGCYPVLS 185
Cdd:COG0666   84 DDGGNTLLHAA------------------------ARNGDLEIVKLLLEAGADVNARDK--DGETPLHLAAYNGNLEIVK 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 186 ILTQNGADVNAINEASMTPLHMAANMLNKEMMETLIAYGANVNcAVSSTGNTPLKLAVctassKAGRLlgagvSCIRLLL 265
Cdd:COG0666  138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVN-ARDNDGETPLHLAA-----ENGHL-----EIVKLLL 206

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 266 THGAKVNAQDYKGQTAIHEACFGGREAIINLLLEFEANVNILTRNGESPIYMYLQRSCNVRDTALLARLL 335
Cdd:COG0666  207 EAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALL 276
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
79-312 2.60e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.04  E-value: 2.60e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  79 PIHLAAKYHKAQSLLCLLRHGADPEVRDTTGLTTLNLMllhwpvtsttwakpgnrthriltdIQNSSITCLRILCAHGAQ 158
Cdd:COG0666   90 LLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLA------------------------AYNGNLEIVKLLLEAGAD 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 159 VNTQGeiSNKRSPLHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAANMLNKEMMETLIAYGANVNcAVSSTGNTP 238
Cdd:COG0666  146 VNAQD--NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN-AKDNDGKTA 222

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 411147371 239 LKLAVCTASSKAgrllgagvscIRLLLTHGAKVNAQDYKGQTAIHEACFGGREAIINLLLEFEANVNILTRNGE 312
Cdd:COG0666  223 LDLAAENGNLEI----------VKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLL 286
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 140-323 6.53e-21

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 94.56  E-value: 6.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 140 DIQNSSITclRILCAHGAQVNTQGEISNKrSPLHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAANMLNKEMMET 219
Cdd:PHA02878 143 DIIEAEIT--KLLLSYGADINMKDRHKGN-TALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHI 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 220 LIAYGANVNcAVSSTGNTPLKLAVctasskaGRLLgaGVSCIRLLLTHGAKVNAQDY-KGQTAIHEACFGgrEAIINLLL 298
Cdd:PHA02878 220 LLENGASTD-ARDKCGNTPLHISV-------GYCK--DYDILKLLLEHGVDVNAKSYiLGLTALHSSIKS--ERKLKLLL 287

                        170       180
                 ....*....|....*....|....*.
gi 411147371 299 EFEANVNILTRNGESPIYM-YLQRSC 323
Cdd:PHA02878 288 EYGADINSLNSYKLTPLSSaVKQYLC 313
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 149-337 1.80e-20

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 92.81  E-value: 1.80e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 149 LRILCAHGAQVNTqgEISNKRSPLHLAIAYGCY-----PVLSILTQNGADVNAINEASMTPLHMAAN--MLNKEMMETLI 221
Cdd:PHA03100  51 VKILLDNGADINS--STKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISkkSNSYSIVEYLL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 222 AYGANVNcAVSSTGNTPLKLAV--CTASSKAGRLL---GAGVSC---IRLLLTHGAKVNAQDYKGQTAIHEACFGGREAI 293
Cdd:PHA03100 129 DNGANVN-IKNSDGENLLHLYLesNKIDLKILKLLidkGVDINAknrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEF 207

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 411147371 294 INLLLEFEANVNILTRNGESPIYMylqrSCNVRDTALLARLLYH 337
Cdd:PHA03100 208 VKYLLDLGANPNLVNKYGDTPLHI----AILNNNKEIFKLLLNN 247
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 76-309 3.49e-19

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 89.74  E-value: 3.49e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  76 SIIPIHLAAKYHKAQSLLCLLRHGADPEVRDTTGLTtlnlmLLHWPVTS----TTWAKPGNRTH------RILTDIQNSS 145
Cdd:PHA02876 178 CITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLS-----VLECAVDSknidTIKAIIDNRSNinkndlSLLKAIRNED 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 146 ITCLRILCAHGAQVNTQGEISNkrSPLHLAIAYgcyPVLSILT----QNGADVNAINEASMTPLH-MAANMLNKEMMETL 220
Cdd:PHA02876 253 LETSLLLYDAGFSVNSIDDCKN--TPLHHASQA---PSLSRLVpkllERGADVNAKNIKGETPLYlMAKNGYDTENIRTL 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 221 IAYGANVNcAVSSTGNTPLKLAVCTASSKagrllgagvSCIRLLLTHGAKVNAQDYKGQTAIHEACFGGREAIINLLLEF 300
Cdd:PHA02876 328 IMLGADVN-AADRLYITPLHQASTLDRNK---------DIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDY 397


                 ....*....
gi 411147371 301 EANVNILTR 309
Cdd:PHA02876 398 GADIEALSQ 406
PHA03095 PHA03095
ankyrin-like protein; Provisional
 149-283 5.84e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.14  E-value: 5.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 149 LRILCAHGAQVNTQGEIsnKRSPLHLAIAYGCYP---VLSILTQNGADVNAINEASMTPLHMAanMLNK---EMMETLIA 222
Cdd:PHA03095  30 VRRLLAAGADVNFRGEY--GKTPLHLYLHYSSEKvkdIVRLLLEAGADVNAPERCGFTPLHLY--LYNAttlDVIKLLIK 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 411147371 223 YGANVNcAVSSTGNTPLKLAVCTASSKAGrllgagvsCIRLLLTHGAKVNAQDYKGQTAIH 283
Cdd:PHA03095 106 AGADVN-AKDKVGRTPLHVYLSGFNINPK--------VIRLLLRKGADVNALDLYGMTPLA 157
PHA03095 PHA03095
ankyrin-like protein; Provisional
 92-330 8.06e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 72.75  E-value: 8.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  92 LLCLLRHGADPEVRDTTGLTTLNLMLLHwpvtsttwakpgnrthriltdiqNSSITCLRILCAHGAQVNTQGEisNKRSP 171
Cdd:PHA03095  66 VRLLLEAGADVNAPERCGFTPLHLYLYN-----------------------ATTLDVIKLLIKAGADVNAKDK--VGRTP 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 172 LHlaiAYGC-----YPVLSILTQNGADVNAINEASMTPLH--MAANMLNKEMMETLIAYGANVnCAVSSTGNTPL----- 239
Cdd:PHA03095 121 LH---VYLSgfninPKVIRLLLRKGADVNALDLYGMTPLAvlLKSRNANVELLRLLIDAGADV-YAVDDRFRSLLhhhlq 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 240 ------------------KLAVCTASSKAGRLLGAGVSCIRL----LLTHGAKVNAQDYKGQTAIHEA-CFGGREAiINL 296
Cdd:PHA03095 197 sfkprarivreliragcdPAATDMLGNTPLHSMATGSSCKRSlvlpLLIAGISINARNRYGQTPLHYAaVFNNPRA-CRR 275

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 411147371 297 LLEFEANVNILTRNGESPIYMYLqRSCNVR--DTAL 330
Cdd:PHA03095 276 LIALGADINAVSSDGNTPLSLMV-RNNNGRavRAAL 310
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 149-311 2.46e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 71.18  E-value: 2.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 149 LRILCAHGAQVNTQgeISNKRSPLHLAIAYGCYPVLSILTQNGADVN-AINEASMTPLHMAANMLNKEMMETLIAYGANV 227
Cdd:PHA02875  51 IKLLMKHGAIPDVK--YPDIESELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADP 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 228 NcaVSSTGN-TPLKLAVctasskagrlLGAGVSCIRLLLTHGAKVNAQDYKGQTAIHEACFGGREAIINLLLEFEANVNI 306
Cdd:PHA02875 129 D--IPNTDKfSPLHLAV----------MMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDY 196


                 ....*
gi 411147371 307 LTRNG 311
Cdd:PHA02875 197 FGKNG 201
Ank_2 pfam12796
Ankyrin repeats (3 copies);
172-275 4.20e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 4.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  172 LHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAANMLNKEMMETLIAYgANVNCAVSstGNTPLKLAVctassKAG 251
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN--GRTALHYAA-----RSG 72

                          90       100
                  ....*....|....*....|....
gi 411147371  252 RLlgagvSCIRLLLTHGAKVNAQD 275
Cdd:pfam12796  73 HL-----EIVKLLLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 79-320 4.24e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 67.78  E-value: 4.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  79 PIHLAAKYHKAQSLLC-LLRHGADPEVRDTTGLTTLNLMllhwpvtsttwAKPGNRTHRIltdiqnssitclRILCAHGA 157
Cdd:PHA02876 276 PLHHASQAPSLSRLVPkLLERGADVNAKNIKGETPLYLM-----------AKNGYDTENI------------RTLIMLGA 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 158 QVNTQGEISNkrSPLHLAIAYGCYPVLSI-LTQNGADVNAINEASMTPLHMAANMLNKEMMETLIAYGANVNcAVSSTGN 236
Cdd:PHA02876 333 DVNAADRLYI--TPLHQASTLDRNKDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIE-ALSQKIG 409

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 237 TPLKLAVCTASSkagrllgagVSCIRLLLTHGAKVNAQDYKGQTAIHEACFGG-REAIINLLLEFEANVNILTRNGESPI 315
Cdd:PHA02876 410 TALHFALCGTNP---------YMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPL 480


                 ....*
gi 411147371 316 YMYLQ 320
Cdd:PHA02876 481 LIALE 485
PHA03095 PHA03095
ankyrin-like protein; Provisional
 77-243 2.83e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 65.05  E-value: 2.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  77 IIPIHLAAKYHKAQSLLCLLRHGADPEVRDTTGLT--------------TLNLMLLHwpVTSTTWAKPGNRT--HRILTD 140
Cdd:PHA03095 120 PLHVYLSGFNINPKVIRLLLRKGADVNALDLYGMTplavllksrnanveLLRLLIDA--GADVYAVDDRFRSllHHHLQS 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 141 IQNSSiTCLRILCAHGAQVNTQGEISNkrSPLHLAIAYGC--YPVLSILTQNGADVNAINEASMTPLHMAANMLNKEMME 218
Cdd:PHA03095 198 FKPRA-RIVRELIRAGCDPAATDMLGN--TPLHSMATGSSckRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACR 274

                        170       180
                 ....*....|....*....|....*
gi 411147371 219 TLIAYGANVNCaVSSTGNTPLKLAV 243
Cdd:PHA03095 275 RLIALGADINA-VSSDGNTPLSLMV 298
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 141-351 1.20e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 63.06  E-value: 1.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 141 IQNSSITCLRILCAHGAQVNTQGeiSNKRSPLHLAIAYGCYPVLSILTQNGADVnaineaSMTPLhmaaNMLNKEMMETL 220
Cdd:PHA02874  43 IRSGDAKIVELFIKHGADINHIN--TKIPHPLLTAIKIGAHDIIKLLIDNGVDT------SILPI----PCIEKDMIKTI 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 221 IAYGANVNcavssTGNTPLKLAVCTASSKAGrllgagVSCIRLLLTHGAKVNAQDYKGQTAIHEACFGGREAIINLLLEF 300
Cdd:PHA02874 111 LDCGIDVN-----IKDAELKTFLHYAIKKGD------LESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEK 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 411147371 301 EANVNILTRNGESPiymyLQRSCNVRDTALLARLLYHTYPLRMTNNQGILP 351
Cdd:PHA02874 180 GAYANVKDNNGESP----LHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTP 226
Ank_4 pfam13637
Ankyrin repeats (many copies);
169-221 6.44e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.59  E-value: 6.44e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 411147371  169 RSPLHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAANMLNKEMMETLI 221
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 261-315 6.48e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 61.07  E-value: 6.48e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 411147371 261 IRLLLTHGAKVNAQDYKGQTAIHEACFGGREAIINLLLEFEANVNILTRNGESPI 315
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPL 152
Ank_2 pfam12796
Ankyrin repeats (3 copies);
205-306 7.39e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.51  E-value: 7.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  205 LHMAANMLNKEMMETLIAYGANVNCaVSSTGNTPLKLAVctassKAGRLlgagvSCIRLLLTHgAKVNAQDYkGQTAIHE 284
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANL-QDKNGRTALHLAA-----KNGHL-----EIVKLLLEH-ADVNLKDN-GRTALHY 67

                          90       100
                  ....*....|....*....|..
gi 411147371  285 ACFGGREAIINLLLEFEANVNI 306
Cdd:pfam12796  68 AARSGHLEIVKLLLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
80-198 5.10e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.20  E-value: 5.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371   80 IHLAAKYHKAQSLLCLLRHGADPEVRDTTGLTTLnlmllhwpvtstTWAkpgnrthriltdIQNSSITCLRILCAHGAQV 159
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTAL------------HLA------------AKNGHLEIVKLLLEHADVN 56

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 411147371  160 NTqgeiSNKRSPLHLAIAYGCYPVLSILTQNGADVNAIN 198
Cdd:pfam12796  57 LK----DNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 194-319 2.67e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 55.80  E-value: 2.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 194 VNAINEASMTPLHMAANMLNKEMMETLIAYGANVNCAvSSTGNTPLKLAVCTASSKagrllgaGVSCIRLLLTHGAKVNA 273
Cdd:PHA03095   7 VDIIMEAALYDYLLNASNVTVEEVRRLLAAGADVNFR-GEYGKTPLHLYLHYSSEK-------VKDIVRLLLEAGADVNA 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 411147371 274 QDYKGQTAIH-EACFGGREAIINLLLEFEANVNILTRNGESPIYMYL 319
Cdd:PHA03095  79 PERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYL 125
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 79-208 8.25e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.12  E-value: 8.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  79 PIHLAAKYHKAQSLLCLLRHGADPEVRDTTGLTTlnlmlLHWPVTSTTwakpgnrthriltdiqnsSITCLRILCAHGAQ 158
Cdd:PHA02878 204 PLHHAVKHYNKPIVHILLENGASTDARDKCGNTP-----LHISVGYCK------------------DYDILKLLLEHGVD 260

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 411147371 159 VNTQGEISNkRSPLHLAIAygCYPVLSILTQNGADVNAINEASMTPLHMA 208
Cdd:PHA02878 261 VNAKSYILG-LTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSSA 307
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 183-317 1.69e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.53  E-value: 1.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 183 VLSILTQNGADVNAINEASMTPLHMAANMLNKEMMETLIAYGANVN-----------CAVSSTGNTPLKlAVCTASSKAG 251
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNiialddlsvleCAVDSKNIDTIK-AIIDNRSNIN 238

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 411147371 252 RLLGAGVSCIR--------LLLTHGAKVNAQDYKGQTAIHEACFG-GREAIINLLLEFEANVNILTRNGESPIYM 317
Cdd:PHA02876 239 KNDLSLLKAIRnedletslLLYDAGFSVNSIDDCKNTPLHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYL 313
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 183-317 2.09e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 52.66  E-value: 2.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 183 VLSILTQNGADVNAINEASMTPLHMAANMLNKEMMETLIAYGANVNcAVSSTGNTPLKLAVCTASSKAGRLL---GAGVS 259
Cdd:PHA02874  17 IEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADIN-HINTKIPHPLLTAIKIGAHDIIKLLidnGVDTS 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 411147371 260 C----------IRLLLTHGAKVNAQDYKGQTAIHEACFGGREAIINLLLEFEANVNILTRNGESPIYM 317
Cdd:PHA02874  96 IlpipciekdmIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHI 163
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 71-336 2.95e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 52.27  E-value: 2.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  71 TQPTESIIPIHLAAKYHKAQSLLCLLRHGADPEVRDTTGlttlnlmllhwpvtsttwakpgnrTHRILTDIQNSSITCLR 150
Cdd:PHA02874 119 IKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNG------------------------CYPIHIAIKHNFFDIIK 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 151 ILCAHGAQVNTQGeiSNKRSPLHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAAnMLNKEMMETLIAyGANVNcA 230
Cdd:PHA02874 175 LLLEKGAYANVKD--NNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAI-IHNRSAIELLIN-NASIN-D 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 231 VSSTGNTPLKLAVCTASSKagrllgagvSCIRLLLTHGAKVNAQDYKGQTAIHEAC-FGGREAIINLLLefeANVNILTR 309
Cdd:PHA02874 250 QDIDGSTPLHHAINPPCDI---------DIIDILLYHKADISIKDNKGENPIDTAFkYINKDPVIKDII---ANAVLIKE 317

                        250       260
                 ....*....|....*....|....*..
gi 411147371 310 NGESPIYMYLQRScNVRDTALLARLLY 336
Cdd:PHA02874 318 ADKLKDSDFLEHI-EIKDNKEFSDFIK 343
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 172-283 1.89e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.01  E-value: 1.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 172 LHLAIAYGCYPVLSILTQNGADVnaINEA-------SMTPLHMAANMLNKEMMETLIAYGANVNCA-VSST--------- 234
Cdd:cd22192   55 LHVAALYDNLEAAVVLMEAAPEL--VNEPmtsdlyqGETALHIAVVNQNLNLVRELIARGADVVSPrATGTffrpgpknl 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 411147371 235 ---GNTPLKLAVCTASSKAgrllgagvscIRLLLTHGAKVNAQDYKGQTAIH 283
Cdd:cd22192  133 iyyGEHPLSFAACVGNEEI----------VRLLIEHGADIRAQDSLGNTVLH 174
PHA02743 PHA02743
Viral ankyrin protein; Provisional
 143-235 6.16e-06

Viral ankyrin protein; Provisional


Pssm-ID: 222925 [Multi-domain]  Cd Length: 166  Bit Score: 46.35  E-value: 6.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 143 NSSITCLRILCAHGAQVNTQgEISNKRSPLHLAIAYGCYPVLSILTQN-GADVNAINEASMTPLHMAANMLNKEMMETLI 221
Cdd:PHA02743  70 ANAVMKIELLVNMGADINAR-ELGTGNTLLHIAASTKNYELAEWLCRQlGVNLGAINYQHETAYHIAYKMRDRRMMEILR 148

                         90
                 ....*....|....
gi 411147371 222 AYGANVNCAVSSTG 235
Cdd:PHA02743 149 ANGAVCDDPLSIGL 162
Ank_4 pfam13637
Ankyrin repeats (many copies);
258-298 1.14e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 1.14e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 411147371  258 VSCIRLLLTHGAKVNAQDYKGQTAIHEACFGGREAIINLLL 298
Cdd:pfam13637  14 LELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 170-308 1.16e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 47.29  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 170 SPLHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAANMLNKEMMETLIAYGANVNCAvSSTGNTPLKLAVCTASsk 249
Cdd:PHA02875 104 TPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIE-DCCGCTPLIIAMAKGD-- 180

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 250 agrllgagVSCIRLLLTHGAKVNAQDYKGQ-TAIHEACFGGREAIINLLLEFEANVNILT 308
Cdd:PHA02875 181 --------IAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADCNIMF 232
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 28-228 1.98e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.52  E-value: 1.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  28 LHSKLYEAIMREDCTTIEVLLrnhpvnqpitiLPNSASNRLLLTqptESIIPIHLAAKYHKAQSLLCLLRHGADPEVRDT 107
Cdd:PHA02875  68 IESELHDAVEEGDVKAVEELL-----------DLGKFADDVFYK---DGMTPLHLATILKKLDIMKLLIARGADPDIPNT 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 108 TGLTTLNLMLLHWPVTSTTWAkpgnRTHRILTDIQNSsitclrilCAHgaqvntqgeisnkrSPLHLAIAYGCYPVLSIL 187
Cdd:PHA02875 134 DKFSPLHLAVMMGDIKGIELL----IDHKACLDIEDC--------CGC--------------TPLIIAMAKGDIAICKML 187

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 411147371 188 TQNGADVNAINEASMTPLHMAANMLNK-EMMETLIAYGANVN 228
Cdd:PHA02875 188 LDSGANIDYFGKNGCVAALCYAIENNKiDIVRLFIKRGADCN 229
Ank_2 pfam12796
Ankyrin repeats (3 copies);
258-316 2.33e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.80  E-value: 2.33e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 411147371  258 VSCIRLLLTHGAKVNAQDYKGQTAIHEACFGGREAIINLLLEFeANVNILTrNGESPIY 316
Cdd:pfam12796  10 LELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALH 66
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 168-282 2.51e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 45.74  E-value: 2.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 168 KRSPLHLAIAYGCYPVLSILTQNGADVNAINEASM----TPLHMAANMLNKEMMETLIAYGANVNCAVSSTGNTPLKLAV 243
Cdd:PHA02884  33 IANILYSSIKFHYTDIIDAILKLGADPEAPFPLSEnsktNPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYISV 112

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 411147371 244 CTASSKagrllgagvsCIRLLLTHGAKVNAQDYKGQTAI 282
Cdd:PHA02884 113 LHGCLK----------CLEILLSYGADINIQTNDMVTPI 141
PHA02946 PHA02946
ankyin-like protein; Provisional
 171-320 3.34e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 45.82  E-value: 3.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 171 PLHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAANMLNK--EMMETLIAYGANVNCAVSSTGNTPlkLAVCTASS 248
Cdd:PHA02946  75 PLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEviERINLLVQYGAKINNSVDEEGCGP--LLACTDPS 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 249 KA--GRLLGAG------------------------VSCIRLLLTHGAKVNAQDYKGQTAIHEACFGGREA--IINLLLEf 300
Cdd:PHA02946 153 ERvfKKIMSIGfearivdkfgknhihrhlmsdnpkASTISWMMKLGISPSKPDHDGNTPLHIVCSKTVKNvdIINLLLP- 231

                        170       180
                 ....*....|....*....|
gi 411147371 301 EANVNILTRNGESPIYMYLQ 320
Cdd:PHA02946 232 STDVNKQNKFGDSPLTLLIK 251
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 149-225 1.41e-04

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 41.79  E-value: 1.41e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 411147371 149 LRILCAHGAQVNTQGEIsNKRSPLHLAIAYGCYPVLSIL-TQNGADVNAINEASMTPLHMAANMLNKEMMETLIAYGA 225
Cdd:PHA02736  74 LKLLMEWGADINGKERV-FGNTPLHIAVYTQNYELATWLcNQPGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGA 150
Ank_5 pfam13857
Ankyrin repeats (many copies);
186-242 2.09e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 2.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 411147371  186 ILTQNGADVNAINEASMTPLHMAANMLNKEMMETLIAYGANVNcAVSSTGNTPLKLA 242
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLN-LKDEEGLTALDLA 56
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 194-326 2.10e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 42.11  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 194 VNAINEASMTPLH--MAANMLNKEMMETLIAYGANVNCAVSstgntplklavctasskagrllGAGVSCIRLLLTHGAKV 271
Cdd:PHA02859  44 VNDCNDLYETPIFscLEKDKVNVEILKFLIENGADVNFKTR----------------------DNNLSALHHYLSFNKNV 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 411147371 272 NaqdykgqtaiheacfggrEAIINLLLEFEANVNILTRNGESPIYMYLQrSCNVR 326
Cdd:PHA02859 102 E------------------PEILKILIDSGSSITEEDEDGKNLLHMYMC-NFNVR 137
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 189-302 2.79e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.32  E-value: 2.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 189 QNGADVNAINEASmtpLHMAANMLNKEMMETLIAYGANVNCAvSSTGNTPLKLAvctaSSKAGRllgagvSCIRLLLTHG 268
Cdd:PLN03192 516 NGGEHDDPNMASN---LLTVASTGNAALLEELLKAKLDPDIG-DSKGRTPLHIA----ASKGYE------DCVLVLLKHA 581

                         90       100       110
                 ....*....|....*....|....*....|....
gi 411147371 269 AKVNAQDYKGQTAIHEACFGGREAIINLLLEFEA 302
Cdd:PLN03192 582 CNVHIRDANGNTALWNAISAKHHKIFRILYHFAS 615
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 170-372 6.86e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.99  E-value: 6.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  170 SPLHLAIAYGCYPVLSILTQNGADVNAineasmtplhmAANmlNKEMMETliaygANVNCAvsSTGNTPLKLAVCTASSk 249
Cdd:TIGR00870 130 TALHLAAHRQNYEIVKLLLERGASVPA-----------RAC--GDFFVKS-----QGVDSF--YHGESPLNAAACLGSP- 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  250 agrllgagvSCIRLLLTHGAKVNAQDYKGQTAIHeacfggreaIINLLLEFEANvniltrngespiymYLQRSCNVRDTA 329
Cdd:TIGR00870 189 ---------SIVALLSEDPADILTADSLGNTLLH---------LLVMENEFKAE--------------YEELSCQMYNFA 236

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 411147371  330 LlaRLLYHTYPLR----MTNNQGILPAGIMLPEFR--LLRDTL-IKQSQK 372
Cdd:TIGR00870 237 L--SLLDKLRDSKelevILNHQGLTPLKLAAKEGRivLFRLKLaIKYKQK 284
PHA02917 PHA02917
ankyrin-like protein; Provisional
 258-337 7.63e-04

ankyrin-like protein; Provisional


Pssm-ID: 165231 [Multi-domain]  Cd Length: 661  Bit Score: 41.91  E-value: 7.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 258 VSCIRLLLTHGAKVNAQDYKGQTAIHEACFGGREAIINLLLEFEANVNILTRNGESPIYMYLQRScnvRDTALLARLLYH 337
Cdd:PHA02917 432 LSTINICLPYLKDINMIDKRGETLLHKAVRYNKQSLVSLLLESGSDVNIRSNNGYTCIAIAINES---RNIELLKMLLCH 508
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 202-229 7.87e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 7.87e-04
                           10        20
                   ....*....|....*....|....*...
gi 411147371   202 MTPLHMAANMLNKEMMETLIAYGANVNC 229
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADINA 30
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 79-241 1.20e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 41.39  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  79 PIHLAAKYHKAQSLLCLLRHGADPEVRDTTGLTTLnlmllhwpvtsttWAKPGNRTHRIltdiqnssitcLRIL--CAHG 156
Cdd:PLN03192 561 PLHIAASKGYEDCVLVLLKHACNVHIRDANGNTAL-------------WNAISAKHHKI-----------FRILyhFASI 616

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 157 AQVNTQGEIsnkrspLHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAANMLNKEMMETLIAYGANVNCAVSSTGN 236
Cdd:PLN03192 617 SDPHAAGDL------LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDDF 690


                 ....*
gi 411147371 237 TPLKL 241
Cdd:PLN03192 691 SPTEL 695
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 186-284 1.62e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 186 ILTQNGADVNAINEASMTPLHMAANMLNKEMMETLIAYGANVNcAVSSTGNTPLKLAVCTASSKAGRLLgagVSCIRLLL 265
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPT-LLDKDGKTPLELAEENGFREVVQLL---SRHSQCHF 175

                         90
                 ....*....|....*....
gi 411147371 266 THGAKVNAQDYKGQTAIHE 284
Cdd:PTZ00322 176 ELGANAKPDSFTGKPPSLE 194
PHA02798 PHA02798
ankyrin-like protein; Provisional
 197-325 1.66e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.59  E-value: 1.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 197 INEASMTPLHMAANMLNKEMMETLIAYGANVNcAVSSTGNTPLklavCTASSKAGRLLGAgVSCIRLLLTHGAKVNAQDY 276
Cdd:PHA02798  34 VNEYSIFQKYLQRDSPSTDIVKLFINLGANVN-GLDNEYSTPL----CTILSNIKDYKHM-LDIVKILIENGADINKKNS 107

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 411147371 277 KGQTAI----HEACFGGREaIINLLLEFEANVNILTRNGESPIYMYLQRSCNV 325
Cdd:PHA02798 108 DGETPLycllSNGYINNLE-ILLFMIENGADTTLLDKDGFTMLQVYLQSNHHI 159
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 184-304 1.84e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 40.62  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 184 LSILTQNGADVNAINEASMTPLHMAANMLNKEMMETLIAYGANVNCAvSSTGNTPLKLAVCTASSKAGRLL--------- 254
Cdd:PLN03192 541 LEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIR-DANGNTALWNAISAKHHKIFRILyhfasisdp 619

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 411147371 255 --GAGVSC----------IRLLLTHGAKVNAQDYKGQTAIHEACFGGREAIINLLLEFEANV 304
Cdd:PLN03192 620 haAGDLLCtaakrndltaMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 150-223 2.11e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.27  E-value: 2.11e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 411147371 150 RILCAHGAQVNTQGeiSNKRSPLHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAANMLNKEMMETLIAY 223
Cdd:PTZ00322  99 RILLTGGADPNCRD--YDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 85-216 2.20e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 39.58  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371  85 KYHKAQSLLCLLRHGADPEVRdttglttlnlmllhWPVTSTTWAKPgnrthrILTDIQNSSITCLRILCAHGAQVNTQGE 164
Cdd:PHA02884  42 KFHYTDIIDAILKLGADPEAP--------------FPLSENSKTNP------LIYAIDCDNDDAAKLLIRYGADVNRYAE 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 411147371 165 ISnKRSPLHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAANMLNKEM 216
Cdd:PHA02884 102 EA-KITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELALMICNNFL 152
Ank_5 pfam13857
Ankyrin repeats (many copies);
264-315 2.24e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 2.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 411147371  264 LLTHG-AKVNAQDYKGQTAIHEACFGGREAIINLLLEFEANVNILTRNGESPI 315
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 202-229 3.28e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 3.28e-03
                          10        20
                  ....*....|....*....|....*....
gi 411147371  202 MTPLHMAANMLNK-EMMETLIAYGANVNC 229
Cdd:pfam00023   3 NTPLHLAAGRRGNlEIVKLLLSKGADVNA 31
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 140-226 4.02e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 38.26  E-value: 4.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 411147371 140 DIQNSSITCLRILCAHGAQVN--TQGeisNKRSPLHLAIAYG---CYPVLSILTQNGADVNAINEASMTPLHMAANMLNK 214
Cdd:PHA02859  60 EKDKVNVEILKFLIENGADVNfkTRD---NNLSALHHYLSFNknvEPEILKILIDSGSSITEEDEDGKNLLHMYMCNFNV 136

                         90
                 ....*....|....
gi 411147371 215 --EMMETLIAYGAN 226
Cdd:PHA02859 137 riNVIKLLIDSGVS 150
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 167-196 4.41e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.54  E-value: 4.41e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 411147371  167 NKRSPLHLAIAYGCYPVLSILTQNGADVNA 196
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA03095 PHA03095
ankyrin-like protein; Provisional
 261-333 4.75e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 39.24  E-value: 4.75e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 411147371 261 IRLLLTHGAKVNAQDYKGQTAIHE--ACFGG-REAIINLLLEFEANVNILTRNGESPIYMYLQRSCNVRDTALLAR 333
Cdd:PHA03095  30 VRRLLAAGADVNFRGEYGKTPLHLylHYSSEkVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLDVIKLLIK 105
PHA03095 PHA03095
ankyrin-like protein; Provisional
 79-119 6.39e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.47  E-value: 6.39e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 411147371  79 PIHLAAKYHKAQSLLCLLRHGADPEVRDTTGLTTLNLMLLH 119
Cdd:PHA03095 260 PLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRN 300
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 167-199 8.53e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 33.80  E-value: 8.53e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 411147371  167 NKRSPLHLAIA-YGCYPVLSILTQNGADVNAINE 199
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
280-317 9.96e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.17  E-value: 9.96e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 411147371  280 TAIHEACFGGREAIINLLLEFEANVNILTRNGESPIYM 317
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHF 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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