protocadherin-11 X-linked isoform a precursor [Mus musculus]
protocadherin; cadherin repeat domain-containing protein( domain architecture ID 13228258)
protocadherin is a transmembrane protein belonging to the cadherin superfamily and may be a calcium-dependent cell-adhesion protein| cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
Protocadherin | pfam08374 | Protocadherin; The structure of protocadherins is similar to that of classic cadherins ... |
775-977 | 2.27e-86 | ||||
Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated. : Pssm-ID: 462451 Cd Length: 217 Bit Score: 280.09 E-value: 2.27e-86
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
253-351 | 1.15e-33 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. : Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 125.12 E-value: 1.15e-33
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
574-669 | 3.56e-32 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. : Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 120.88 E-value: 3.56e-32
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
471-566 | 5.46e-32 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. : Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 120.11 E-value: 5.46e-32
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
143-245 | 7.57e-20 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. : Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 85.83 E-value: 7.57e-20
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
680-772 | 2.41e-16 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. : Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 75.81 E-value: 2.41e-16
|
||||||||
CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
384-464 | 5.69e-11 | ||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. : Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 59.67 E-value: 5.69e-11
|
||||||||
Cadherin_2 super family | cl29227 | Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain. |
28-99 | 1.50e-05 | ||||
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain. The actual alignment was detected with superfamily member pfam08266: Pssm-ID: 462413 Cd Length: 83 Bit Score: 44.44 E-value: 1.50e-05
|
||||||||
FAM47 super family | cl25915 | FAM47 family; The function of this Chordate family of proteins is not known. |
1148-1223 | 2.04e-04 | ||||
FAM47 family; The function of this Chordate family of proteins is not known. The actual alignment was detected with superfamily member pfam14642: Pssm-ID: 405345 [Multi-domain] Cd Length: 257 Bit Score: 44.87 E-value: 2.04e-04
|
||||||||
Name | Accession | Description | Interval | E-value | ||||
Protocadherin | pfam08374 | Protocadherin; The structure of protocadherins is similar to that of classic cadherins ... |
775-977 | 2.27e-86 | ||||
Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated. Pssm-ID: 462451 Cd Length: 217 Bit Score: 280.09 E-value: 2.27e-86
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
253-351 | 1.15e-33 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 125.12 E-value: 1.15e-33
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
574-669 | 3.56e-32 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 120.88 E-value: 3.56e-32
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
471-566 | 5.46e-32 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 120.11 E-value: 5.46e-32
|
||||||||
CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
489-568 | 9.74e-25 | ||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 98.96 E-value: 9.74e-25
|
||||||||
Cadherin | pfam00028 | Cadherin domain; |
254-346 | 1.73e-23 | ||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 95.83 E-value: 1.73e-23
|
||||||||
CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
593-671 | 6.26e-23 | ||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 93.95 E-value: 6.26e-23
|
||||||||
CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
272-353 | 2.03e-22 | ||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 92.41 E-value: 2.03e-22
|
||||||||
Cadherin | pfam00028 | Cadherin domain; |
575-663 | 7.92e-21 | ||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 88.13 E-value: 7.92e-21
|
||||||||
Cadherin | pfam00028 | Cadherin domain; |
471-561 | 1.29e-20 | ||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 87.74 E-value: 1.29e-20
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
143-245 | 7.57e-20 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 85.83 E-value: 7.57e-20
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
680-772 | 2.41e-16 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 75.81 E-value: 2.41e-16
|
||||||||
CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
163-247 | 4.48e-16 | ||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 74.31 E-value: 4.48e-16
|
||||||||
CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
384-464 | 5.69e-11 | ||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 59.67 E-value: 5.69e-11
|
||||||||
Cadherin | pfam00028 | Cadherin domain; |
144-239 | 5.88e-11 | ||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 60.01 E-value: 5.88e-11
|
||||||||
Cadherin | pfam00028 | Cadherin domain; |
370-456 | 1.15e-08 | ||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 53.46 E-value: 1.15e-08
|
||||||||
Cadherin | pfam00028 | Cadherin domain; |
691-772 | 1.41e-08 | ||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 53.46 E-value: 1.41e-08
|
||||||||
CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
699-772 | 1.41e-07 | ||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 50.04 E-value: 1.41e-07
|
||||||||
Cadherin_2 | pfam08266 | Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain. |
28-99 | 1.50e-05 | ||||
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain. Pssm-ID: 462413 Cd Length: 83 Bit Score: 44.44 E-value: 1.50e-05
|
||||||||
FAM47 | pfam14642 | FAM47 family; The function of this Chordate family of proteins is not known. |
1148-1223 | 2.04e-04 | ||||
FAM47 family; The function of this Chordate family of proteins is not known. Pssm-ID: 405345 [Multi-domain] Cd Length: 257 Bit Score: 44.87 E-value: 2.04e-04
|
||||||||
KLF10_11_N | cd21974 | N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ... |
1141-1268 | 7.99e-04 | ||||
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins. Pssm-ID: 409243 [Multi-domain] Cd Length: 229 Bit Score: 42.61 E-value: 7.99e-04
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
27-135 | 4.45e-03 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 38.06 E-value: 4.45e-03
|
||||||||
Name | Accession | Description | Interval | E-value | ||||
Protocadherin | pfam08374 | Protocadherin; The structure of protocadherins is similar to that of classic cadherins ... |
775-977 | 2.27e-86 | ||||
Protocadherin; The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated. Pssm-ID: 462451 Cd Length: 217 Bit Score: 280.09 E-value: 2.27e-86
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
253-351 | 1.15e-33 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 125.12 E-value: 1.15e-33
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
574-669 | 3.56e-32 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 120.88 E-value: 3.56e-32
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
471-566 | 5.46e-32 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 120.11 E-value: 5.46e-32
|
||||||||
CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
489-568 | 9.74e-25 | ||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 98.96 E-value: 9.74e-25
|
||||||||
Cadherin | pfam00028 | Cadherin domain; |
254-346 | 1.73e-23 | ||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 95.83 E-value: 1.73e-23
|
||||||||
CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
593-671 | 6.26e-23 | ||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 93.95 E-value: 6.26e-23
|
||||||||
CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
272-353 | 2.03e-22 | ||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 92.41 E-value: 2.03e-22
|
||||||||
Cadherin | pfam00028 | Cadherin domain; |
575-663 | 7.92e-21 | ||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 88.13 E-value: 7.92e-21
|
||||||||
Cadherin | pfam00028 | Cadherin domain; |
471-561 | 1.29e-20 | ||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 87.74 E-value: 1.29e-20
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
143-245 | 7.57e-20 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 85.83 E-value: 7.57e-20
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
680-772 | 2.41e-16 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 75.81 E-value: 2.41e-16
|
||||||||
CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
163-247 | 4.48e-16 | ||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 74.31 E-value: 4.48e-16
|
||||||||
CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
384-464 | 5.69e-11 | ||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 59.67 E-value: 5.69e-11
|
||||||||
Cadherin | pfam00028 | Cadherin domain; |
144-239 | 5.88e-11 | ||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 60.01 E-value: 5.88e-11
|
||||||||
Cadherin | pfam00028 | Cadherin domain; |
370-456 | 1.15e-08 | ||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 53.46 E-value: 1.15e-08
|
||||||||
Cadherin | pfam00028 | Cadherin domain; |
691-772 | 1.41e-08 | ||||
Cadherin domain; Pssm-ID: 394985 [Multi-domain] Cd Length: 92 Bit Score: 53.46 E-value: 1.41e-08
|
||||||||
CA_like | cd00031 | Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
471-566 | 4.15e-08 | ||||
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan. Pssm-ID: 206635 Cd Length: 98 Bit Score: 52.35 E-value: 4.15e-08
|
||||||||
CA | smart00112 | Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ... |
699-772 | 1.41e-07 | ||||
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium. Pssm-ID: 214520 [Multi-domain] Cd Length: 81 Bit Score: 50.04 E-value: 1.41e-07
|
||||||||
Cadherin_2 | pfam08266 | Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain. |
254-319 | 1.79e-06 | ||||
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain. Pssm-ID: 462413 Cd Length: 83 Bit Score: 47.14 E-value: 1.79e-06
|
||||||||
Cadherin_2 | pfam08266 | Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain. |
28-99 | 1.50e-05 | ||||
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain. Pssm-ID: 462413 Cd Length: 83 Bit Score: 44.44 E-value: 1.50e-05
|
||||||||
FAM47 | pfam14642 | FAM47 family; The function of this Chordate family of proteins is not known. |
1148-1223 | 2.04e-04 | ||||
FAM47 family; The function of this Chordate family of proteins is not known. Pssm-ID: 405345 [Multi-domain] Cd Length: 257 Bit Score: 44.87 E-value: 2.04e-04
|
||||||||
KLF10_11_N | cd21974 | N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ... |
1141-1268 | 7.99e-04 | ||||
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins. Pssm-ID: 409243 [Multi-domain] Cd Length: 229 Bit Score: 42.61 E-value: 7.99e-04
|
||||||||
KLF3_N | cd21577 | N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called ... |
1154-1257 | 8.98e-04 | ||||
N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called Krueppel-like factor 3 and originally called Basic Kruppel-like Factor/BKLF), was the third member of the KLF family of zinc finger transcription factors to be discovered. KLF3 possesses a wide range of biological impacts on regulating apoptosis, differentiation, and proliferation in various tissues during the entire progression process. It has been proposed as a tumor suppressor in colorectal cancer. It appears to function predominantly as a repressor of transcription, turning genes off by recruiting the C-terminal Binding Protein co-repressors CtBP1 and CtBP2. CtBP docks onto a short motif (residues 61-65) in the N-terminus of KLF3, through the Proline-X-Aspartate-Leucine-Serine (PXDLS) motif. CtBP in turn recruits histone modifying enzymes to alter chromatin and repress gene expression. KLF3 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF3. Pssm-ID: 410554 [Multi-domain] Cd Length: 214 Bit Score: 42.33 E-value: 8.98e-04
|
||||||||
CA_like | cd00031 | Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
254-351 | 2.77e-03 | ||||
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan. Pssm-ID: 206635 Cd Length: 98 Bit Score: 38.48 E-value: 2.77e-03
|
||||||||
KLF10_11_N | cd21974 | N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ... |
1128-1246 | 3.87e-03 | ||||
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins. Pssm-ID: 409243 [Multi-domain] Cd Length: 229 Bit Score: 40.30 E-value: 3.87e-03
|
||||||||
Cadherin_repeat | cd11304 | Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
27-135 | 4.45e-03 | ||||
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. Pssm-ID: 206637 [Multi-domain] Cd Length: 98 Bit Score: 38.06 E-value: 4.45e-03
|
||||||||
Blast search parameters | ||||
|