BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  31 FVDVTLACEGRSIKAHRVVLSACSPYFRELLKST-PCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEV 109
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 442614775 110 LRVSG 114
Cdd:cd18315   81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  31 FVDVTLACEGRSIKAHRVVLSACSPYFRELLKST-PCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEV 109
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 442614775 110 LRVSG 114
Cdd:cd18315   81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775    33 DVTLACEGRSIKAHRVVLSACSPYFRELLKSTPC--KHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVL 110
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*...
gi 442614775   111 RVSGLTQQ 118
Cdd:smart00225  81 QIPGLVEL 88

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  31 FVDVTLACEGRSIKAHRVVLSACSPYFRELLKST-PCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEV 109
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 442614775 110 LRVSG 114
Cdd:cd18315   81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775    33 DVTLACEGRSIKAHRVVLSACSPYFRELLKSTPC--KHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVL 110
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*...
gi 442614775   111 RVSGLTQQ 118
Cdd:smart00225  81 QIPGLVEL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  16 SSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYHGEV 93
Cdd:cd18247    4 SSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHdmVESKQDEITMQGIEPSALEALINFAYSGRI 83

                         90
                 ....*....|....*..
gi 442614775  94 NVHQKSLQSFLKTAEVL 110
Cdd:cd18247   84 AIDTSNVQSLLVGASFL 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  15 QSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYHGE 92
Cdd:cd18237    5 LADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSnmTESKSSEVELKDAEPDIIELLVEFAYTAR 84

                         90
                 ....*....|....*
gi 442614775  93 VNVHQKSLQSFLKTA 107
Cdd:cd18237   85 ISVNSNNVQSLLDAA 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  13 NYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTPCK--HPVILLQDVNFMDLHALVEFIYH 90
Cdd:cd18256    2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSEssKDVVQIHGVEPDIFHILLDFIYT 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 442614775  91 GEVNVHQKSLQSFLKTAEVLRVSGLTQQQAEDTHSHL 127
Cdd:cd18256   82 GVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQL 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  25 LRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTPCK--HPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQS 102
Cdd:cd18257   12 LRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEkeNSEVEFQCIDETALQAIVEYAYTGTVFISQATVES 91

                         90       100
                 ....*....|....*....|....*
gi 442614775 103 FLKTAEVLRVSGLTQQQAEDTHSHL 127
Cdd:cd18257   92 LLPAANLLQIKLVLKECCDFLESQL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  12 NNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIY 89
Cdd:cd18242    2 NSHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSemSEKGKSEVELQGLTASTMEILLDFVY 81

                         90       100
                 ....*....|....*....|....*...
gi 442614775  90 HGEVNVHQKSLQSFLKTAEVLRVSGLTQ 117
Cdd:cd18242   82 TETVHVTVENVQELLPAACLLQLKGVKQ 109

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  22 FENLRDDEAFVDVTL-ACEGRSIKAHRVVLSACSPYFRELLkstpCKHPVILL-QDVNFMDLHALVEFIYHGEVNVHQKS 99
Cdd:cd18299    3 LRNLLHSPSCADVVFiLQGGVRIFAHRIVLAAASSVFADLF----LMMTVVTLdSDITPEAFRRVLEFLYTGVLDENEDD 78

                         90
                 ....*....|....*...
gi 442614775 100 LQSFLKTAEVLRVSGLTQ 117
Cdd:cd18299   79 LKELKDAAELLELFDLVM 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  17 SITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYHGEVN 94
Cdd:cd18253    4 SILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNdhRESREMLVEINGILAEAMDCFLQYVYTGKVK 83

                         90       100
                 ....*....|....*....|.
gi 442614775  95 VHQKSLQSFLKTAEVLRVSGL 115
Cdd:cd18253   84 ITTENVQYLFETSSLFQISPL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  26 RDDEAFV------DVTLACEGRSIKAHRVVLSACSPYFRELLKSTPC--KHPVILLQDVNFMDLHALVEFIYHGEVNVHQ 97
Cdd:cd18297    1 RIDPHYVnnpemsDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTeaQTPVIEIPDIRYDIFQLMMQYLYTGGVESLD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 442614775  98 KSLQSFLktaEVLRVSGLTQQQAEDTHSH--LAQIQNLAN 135
Cdd:cd18297   81 VAQDDAL---ELLRAASFFQLDGLKRHCEilLSQQIDLDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  25 LRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELL--KSTPCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQS 102
Cdd:cd18338   15 LRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFtgEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQV 94

                         90       100
                 ....*....|....*....|....*
gi 442614775 103 FLKTAEVLRVSGLTQQQAEDTHSHL 127
Cdd:cd18338   95 LLPAAGLLQLQDVKKTCCEFLESQL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  21 AFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTPCKHP----VILLQDVNFMDLHALVEFIYHGEVNVH 96
Cdd:cd18245    4 ALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDgstyKIELEGISVEVMEEILDYIYTGQIKLS 83

                         90
                 ....*....|....*....
gi 442614775  97 QKSLQSFLKTAEVLRVSGL 115
Cdd:cd18245   84 EDNIQDIVQAADLLLMTDL 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  14 YQSSI-TSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYH 90
Cdd:cd18341    9 YQSTLlQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSeeSEEKKKEVVLDNVDPNIMDMILKYLYS 88

                         90
                 ....*....|....*..
gi 442614775  91 GEVNVHQKSLQSFLKTA 107
Cdd:cd18341   89 AEIDLNDGNVQDIFALA 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775   9 LRWNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKStpcKHPVilLQDVNFMD------LH 82
Cdd:cd18212    1 IHSKTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFAD---EGEV--GQSIYMLEgmvaetFG 75

                         90       100       110
                 ....*....|....*....|....*....|...
gi 442614775  83 ALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGL 115
Cdd:cd18212   76 ALLEFIYTGCLQVGEKSLEQILATAQFLKVNDL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  15 QSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKST--PCKHPVILLQDVNFMDLHALVEFIYHGE 92
Cdd:cd18340   11 QTLLQDGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDleESKKREIVLEDVDPDVMGKILHYIYTSE 90

                         90       100
                 ....*....|....*....|
gi 442614775  93 VNVHQKSLQSFLKTAEVLRV 112
Cdd:cd18340   91 IEITEQNVQDIFAAANMFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  31 FVDVTLACEGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAE 108
Cdd:cd18265   23 FTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGhlKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEASD 102

                 ....*..
gi 442614775 109 VLRVSGL 115
Cdd:cd18265  103 LLQVSKL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775   3 DTQHFCLrwNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFR-----ELLKSTPCKhpvILLQDVN 77
Cdd:cd18259    6 DDLDFCL--PSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNamftgDFVESISAR---VEIKDVD 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 442614775  78 FMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVL 110
Cdd:cd18259   81 PAVMESLIDFAYTGKLTINQGNVEALIRTSNRL 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  34 VTLACEGRSIKAHRVVLSACSPYFRELLKSTpCKHP---VILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVL 110
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGG-FRESgqaEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  21 AFENLRDDEAFVDVTLAC-EGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQ 97
Cdd:cd18252   11 AFRTFYLDGLFTDITLQCaSGQIFHCHKAALAACSSYFKVMFTAdmKEKSNNVIKLSGIDHDILEALVNYVYTSQICITE 90

                         90
                 ....*....|....
gi 442614775  98 KSLQSFLKTAEVLR 111
Cdd:cd18252   91 RNVQSLLEAADLLQ 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  18 ITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFREL--LKSTPCKHPVILLQDVNFMDLHALVEFIYHGEVNV 95
Cdd:cd18271   11 ILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMfeVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEI 90

                         90       100
                 ....*....|....*....|..
gi 442614775  96 HQKSLQSFLKTAEVLRVSGLTQ 117
Cdd:cd18271   91 TDDNVEMFFQMSSFLQVSLLSK 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  21 AFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLHALVEFIYHGEVNVHQK 98
Cdd:cd18246   29 SMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNemSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEG 108

                         90
                 ....*....|....*..
gi 442614775  99 SLQSFLKTAEVLRVSGL 115
Cdd:cd18246  109 NVQTLLPAASLLQLNGV 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  14 YQSSITS-----AFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYF-RELLKSTPCKHPVILLQDVNFMDLHALVEF 87
Cdd:cd18277    5 YESSVHStnvllSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFhSRIVGQADAELNITLPEEVTVKGFEPLIQF 84

                         90       100       110
                 ....*....|....*....|....*....|
gi 442614775  88 IYHGEVNVHQKSLQSFLKTAEVLRVSGLTQ 117
Cdd:cd18277   85 AYTAKLILSKDNVDEVCKCVEFLSVHNIEE 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  26 RDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTpCKHPVILLQDVNFMDLHALVEFIYHGEVNVH-QKSLQSFL 104
Cdd:cd18221   13 RELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDF-TQEPLVEIEGVSNMAFRHLIEFTYTAKLMVQgEEEANDVW 91

                 ....*...
gi 442614775 105 KTAEVLRV 112
Cdd:cd18221   92 KAAEYLQM 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  13 NYQSSITSAFENLRDDEAFVDVTLACE--------GRSIKAHRVVLSACSPYFRELLKS--TPCKHPVILLQDVNFMDLH 82
Cdd:cd18273    8 AHARALLAQLKSFYDARLLTDVTIEVNgpgsgpgsGRLFPCNRNVLAAASPYFKSMFTGglYESKQETVTIHDVDSESMA 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442614775  83 ALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAedthSHLAQIQNLANSGG 138
Cdd:cd18273   88 LIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACA----SFLARRLDLSNCVG 139

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  25 LRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTPCKHPVILLqDVNFMDLHALVEFIYHGEVNVHQKSLQSFL 104
Cdd:cd18262   12 LREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRERLLGSNGPLPPLSL-EVTPVGWEAVLTFAYTGVLGRNPATVGDIL 90

                 ....*.
gi 442614775 105 KTAEVL 110
Cdd:cd18262   91 VAAEAL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  13 NYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFrELLKSTPCKHPviLLQDVNFMD------LHALVE 86
Cdd:cd18254    4 SHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYF-EAMFSNGLRES--LDSTVNFHDslhpevLELLLD 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 442614775  87 FIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAE 121
Cdd:cd18254   81 FAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614775  13 NYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTPCKhPVILLQDVNFMDLHALVEFIYHGE 92
Cdd:cd18290    9 NFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSA-VVELPAAVQPQSFQQILSFCYTGR 87

                         90       100
                 ....*....|....*....|....*....
gi 442614775  93 VNVHQKSLQSFLKTAEVLRVSGLTQQQAE 121
Cdd:cd18290   88 LSMNVGDQFLLMYTAGFLQIQEIMEKGTE 116

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442614775  28 DEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLK-----STPCkhpVILLQDVNFMDLHALVEFIYHGEVN 94
Cdd:cd18286   14 NGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSgswaeSNSS---EITLTGVSHAAVSFVLLFIYGGVLD 82