NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|442615836|ref|NP_001259424|]
View 

uncharacterized protein Dmel_CG43347, isoform D [Drosophila melanogaster]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 1031-1146 1.98e-19

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


:

Pssm-ID: 380932  Cd Length: 83  Bit Score: 84.94  E-value: 1.98e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1031 VPAEFELHN--VEPNVTGVFARTEVRAFTKLGPLIGQPvqtgevregsdmkwifemceagadksyllccdnpnasNWLRF 1108
Cdd:cd10534     1 LPAGLELVLssIPEGGLGVFARRTIPAGTRFGPLEGVV-------------------------------------NWMRF 43

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 442615836 1109 VRPAPSYEERNVNLVSIDRQAYFVSCRDLRNGMELLYW 1146
Cdd:cd10534    44 VRPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVW 81
NR_DBD_like super family cl02596
DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers; DNA-binding ...
 1198-1268 8.06e-03

DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. It interacts with a specific DNA site upstream of the target gene and modulates the rate of transcriptional initiation. Nuclear receptors form a superfamily of ligand-activated transcription regulators, which regulate various physiological functions, from development, reproduction, to homeostasis and metabolism in animals (metazoans). The family contains not only receptors for known ligands but also orphan receptors for which ligands do not exist or have not been identified. NRs share a common structural organization with a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). Most nuclear receptors bind as homodimers or heterodimers to their target sites, which consist of two hexameric half-sites. Specificity is determined by the half-site sequence, the relative orientation of the half-sites and the number of spacer nucleotides between the half-sites. However, a growing number of nuclear receptors have been reported to bind to DNA as monomers.


The actual alignment was detected with superfamily member cd07157:

Pssm-ID: 413390  Cd Length: 86  Bit Score: 37.85  E-value: 8.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442615836 1198 CKVCGEPvlgkdnimkhAAEKHdgKGAYQCQFCSKFFLRLNYLEMHRTYGCasnPNRSRPVCDFCGRKFCQ 1268
Cdd:cd07157     3 CQVCGEP----------AAGFH--HGAYVCEACKKFFMRSSNAISFTISEC---PNGGKCIIDKKNRTKCQ 58
 
Name Accession Description Interval E-value
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 1031-1146 1.98e-19

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 84.94  E-value: 1.98e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1031 VPAEFELHN--VEPNVTGVFARTEVRAFTKLGPLIGQPvqtgevregsdmkwifemceagadksyllccdnpnasNWLRF 1108
Cdd:cd10534     1 LPAGLELVLssIPEGGLGVFARRTIPAGTRFGPLEGVV-------------------------------------NWMRF 43

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 442615836 1109 VRPAPSYEERNVNLVSIDRQAYFVSCRDLRNGMELLYW 1146
Cdd:cd10534    44 VRPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVW 81
2DBD_NR_DBD1 cd07157
The first DNA-binding domain (DBD) of the 2DBD nuclear receptors is composed of two C4-type ...
 1198-1268 8.06e-03

The first DNA-binding domain (DBD) of the 2DBD nuclear receptors is composed of two C4-type zinc fingers; The first DNA-binding domain (DBD) of the 2DBD nuclear receptors(NRs) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. NRs interact with specific DNA sites upstream of the target gene and modulate the rate of transcriptional initiation. Theses proteins contain two DBDs in tandem, probably resulted from an ancient recombination event. The 2DBD-NRs are found only in flatworm species, mollusks and arthropods. Their biological function is unknown.


Pssm-ID: 143532  Cd Length: 86  Bit Score: 37.85  E-value: 8.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442615836 1198 CKVCGEPvlgkdnimkhAAEKHdgKGAYQCQFCSKFFLRLNYLEMHRTYGCasnPNRSRPVCDFCGRKFCQ 1268
Cdd:cd07157     3 CQVCGEP----------AAGFH--HGAYVCEACKKFFMRSSNAISFTISEC---PNGGKCIIDKKNRTKCQ 58
 
Name Accession Description Interval E-value
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 1031-1146 1.98e-19

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 84.94  E-value: 1.98e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1031 VPAEFELHN--VEPNVTGVFARTEVRAFTKLGPLIGQPvqtgevregsdmkwifemceagadksyllccdnpnasNWLRF 1108
Cdd:cd10534     1 LPAGLELVLssIPEGGLGVFARRTIPAGTRFGPLEGVV-------------------------------------NWMRF 43

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 442615836 1109 VRPAPSYEERNVNLVSIDRQAYFVSCRDLRNGMELLYW 1146
Cdd:cd10534    44 VRPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVW 81
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 1031-1146 2.84e-16

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 77.10  E-value: 2.84e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1031 VPAEFELHN--VEPNVTGVFARTEVRAFTKLGPLIGqpvqtgEVREGSDMKWIFEMCEAGADKSYLLCCD--NPNASNWL 1106
Cdd:cd19188     4 LPEELELKPsaVDKTRIGVWAKKSIPKGRKFGPFVG------EKKKRSQVKNNVYMWEIYGPKRGWMCVDasDPTKGNWL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 442615836 1107 RFVRPAPSYEERNVNLVSIDRQAYFVSCRDLRNGMELLYW 1146
Cdd:cd19188    78 RYVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCW 117
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 1027-1146 1.44e-14

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 72.88  E-value: 1.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1027 AEASVPAEFEL-HNVEPNVTGVFARTEVRAFTKLGPLIGQPVQTGEVRE--GSDMKWIFEMCEAGADKSYLLCCDNpNAS 1103
Cdd:cd19189     2 ARLSLPRQLYLrQSETGAEVGVWTKETIPVRTCFGPLIGQQSHSAEVADwtDKAAPHIWKIYHNDVLEFCIITTDE-NEC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 442615836 1104 NWLRFVRPAPSYEERNVNLVSIDRQAYFVSCRDLRNGMELLYW 1146
Cdd:cd19189    81 NWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFY 123
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 1027-1146 3.93e-14

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 71.29  E-value: 3.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1027 AEASVPAEFELHNVEPNVTGVFARTEVRAFTKLGPLIGQPVQTGEVREGSDMKwIFEmceagADKSyLLCCD--NPNASN 1104
Cdd:cd19199     3 ARSSLPDNLEIRQLEDGSEGVFALVPLVKRTQFGPFEAKRVARLDGFAVFPLK-VFE-----KDGS-VVYLDtsNEDDCN 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 442615836 1105 WLRFVRPAPSYEERNVNLVSIDRQAYFVSCRDLRNGMELLYW 1146
Cdd:cd19199    76 WMMFVRPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVW 117
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 1046-1150 2.61e-13

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 68.96  E-value: 2.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1046 GVFARTEVRAFTKLGPLIGQPVQTGEVREGSDMKWIFEMCEAGADKSYLlccDN-PNASNWLRFVRPAPSYEERNVNLVS 1124
Cdd:cd19198    21 GVFCKKTIPKGTRFGPFRGRVVNTSEIKTYDDNSFMWEIFEDGKLSHFI---DGrGSTGNWMSYVNCARYAEEQNLIAIQ 97

                          90       100
                  ....*....|....*....|....*.
gi 442615836 1125 IDRQAYFVSCRDLRNGMELLYWSDDC 1150
Cdd:cd19198    98 CQGQIFYESCKEILQGQELLVWYGDC 123
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 1043-1146 6.04e-13

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 67.74  E-value: 6.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1043 NVTGVFARTEVRAFTKLGPLIGQPVQTGEVREGSDMKWIFEMCEAGADKSYLlCCDNPNASNWLRFVRPAPSYEERNVNL 1122
Cdd:cd19187    17 EVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANRKYFWRIYSNGEFYHYI-DGFDPSKSNWMRYVNPAHSLQEQNLVA 95

                          90       100
                  ....*....|....*....|....
gi 442615836 1123 VSIDRQAYFVSCRDLRNGMELLYW 1146
Cdd:cd19187    96 CQIGMNIYFYTVKPIPPNQELLVW 119
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 1031-1144 1.90e-12

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 66.55  E-value: 1.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1031 VPAEFELHNVE-PNVTGVFARTEVRAFTKLGPLIGQPVQTGEVREGSDMKWIFEMCEAGADKSYLLCCDNPNASNWLRFV 1109
Cdd:cd19190     5 VPDRFSLKSSKvQDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRLMWEVRGSKGEVLYILDASNPRHSNWLRFV 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 442615836 1110 RPAPSYEERNVNLVSIDRQAYFVSCRDLRNGMELL 1144
Cdd:cd19190    85 HEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELL 119
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 1030-1149 2.61e-12

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 66.24  E-value: 2.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1030 SVPAEFELHN---VEPNVtGVFARTEVRAFTKLGPLIGqpVQTGEVregSDMKWIFEMC-EAGADKSyllCCD--NPNAS 1103
Cdd:cd19200     9 PIPPDFELREsaaVGAGL-GVWTKVRIEVGEKFGPFVG--VQRSSV---KDPTYAWEIVdEFGKVKF---WIDasEPGTG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 442615836 1104 NWLRFVRPAPSYEERNVNLVSIDRQAYFVSCRDLRNGMELLYWSDD 1149
Cdd:cd19200    80 NWMKYIRSAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLLYMKA 125
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 1027-1146 5.27e-11

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 62.37  E-value: 5.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1027 AEASVPAEFELHNVEPNVTGVFARTEVRAFTKLGPLIGQPVQTgevREGSDMKWIFEMCEAGADKSYLLCCDNPNASNWL 1106
Cdd:cd19194     2 ARASLPLILQIFRFGETLGGVFAKRRIPKRTQFGPLEGPLVKK---SELKDNKIHPLELEEDDGEDLYFDLSDENKCNWM 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 442615836 1107 RFVRPAPSYEERNVNLVSIDRQAYFVSCRDLRNGMELLYW 1146
Cdd:cd19194    79 MFVRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKVW 118
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 1030-1149 8.60e-11

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 61.59  E-value: 8.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1030 SVPAEFELHN---VEPNVTGVFARTEVRAFTKLGPLIGQPVQTGEVREGsDMKWIFEMCEAGADKsYLLCCDNPNasnWL 1106
Cdd:cd19201     2 SLPGELELRKpsqDAGRSGGVWAKQPLPEGTRFGPYPGKLVKEPLDPSY-EWKVEAQGSKGGEGL-LLLTEDSGT---WL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 442615836 1107 RFVRPAPSYEERNVNLVSIDRQAYFVSCRDLRNGMELLYWSDD 1149
Cdd:cd19201    77 KLVRSADDEDEANLILYFKGGQIWCEVTKDIPPGEELILVLRE 119
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 1046-1149 1.12e-09

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 58.64  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1046 GVFARTEVRAFTKLGPLIGQPVQTG-EVREGSDMKWIFEMCEAGADKSYLLCCDNPNASNWLRFVRPAPSYEERNVNLVS 1124
Cdd:cd19191    18 GICAAQRIPQGTWIGPFEGVLVSPEkQIGAVRNTQHLWEIYDQEGTLQHFIDGGDPSKSSWMRYIRCARHCGEQNLTVVQ 97

                          90       100
                  ....*....|....*....|....*
gi 442615836 1125 IDRQAYFVSCRDLRNGMELLYWSDD 1149
Cdd:cd19191    98 YRGCIFYRACRDIPRGTELLVWYDD 122
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 1045-1149 1.88e-09

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 57.83  E-value: 1.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1045 TGVFARTEVRAFTKLGPLIGqpvqtgEVREGSDMKWIfemceagADKSYLL-------------CCDNPNASNWLRFVRP 1111
Cdd:cd19192    20 TSVVTTTDIPAGTIFGPCVL------SFTLGYDIADI-------ALKTTDKrvvpyifrvdtgaCNGSSEPSDWLRLVQP 86

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 442615836 1112 APSYEERNVN-LVSIDRQAYFVSCRDLRNGMELLYWSDD 1149
Cdd:cd19192    87 ARDRHEQNLEaFRKNEGQVYFRTLRRIRKGEELLVWYSD 125
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 1059-1149 2.64e-09

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 57.43  E-value: 2.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1059 LGPLIGQPVQTGEVREGSDMKWIFEMCEAGadksyLLCCDnpnASNWLRFVRPAPSYEERNVNLVSIDRQAYFVSCRDLR 1138
Cdd:cd10520    36 LGPLEEELESHDLTEGGSPRQEESGQSGDV-----LACEQ---SSKWMRFACRARSEEESNVAVVRLSGRLHLRVCKDIE 107

                          90
                  ....*....|.
gi 442615836 1139 NGMELLYWSDD 1149
Cdd:cd10520   108 PGSELLLWPEE 118
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 1031-1149 3.24e-09

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 58.35  E-value: 3.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1031 VPAEFELHnvEPNVTG----VFARTEVRAFTKLGPLIGqpVQTGEVREgSDMKW----------IFEMC------EAGAD 1090
Cdd:cd19213    20 IPSDFELR--ESSIPGaglgVWAKRKIEAGERFGPYTG--VQRSTLKD-TNFGWeqilndvevsSQEGCitkivdDLGNE 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442615836 1091 KSyllCCD-NPNAS-NWLRFVRPAPSYEERNVNLVSIDRQAYFVSCRDLRNGMELLYWSDD 1149
Cdd:cd19213    95 KF---CVDaGQAGAgSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLVYVKD 152
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 1046-1146 3.88e-09

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 56.86  E-value: 3.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1046 GVFARTEVRAFTKLGPLIGQPVQTGEVREGSDMKWIFEmceaGADKSYLLCCDNPNASNWLRFVRPAPSYEERNVNLVSI 1125
Cdd:cd19193    21 GVWAEAPIPKGMVFGPYEGEIVEDEEAADSGYSWQIYK----GGKLSHYIDAKDESKSNWMRYVNCARNEEEQNLVAFQY 96

                          90       100
                  ....*....|....*....|.
gi 442615836 1126 DRQAYFVSCRDLRNGMELLYW 1146
Cdd:cd19193    97 RGKIYYRTCKDIAPGTELLVW 117
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 1024-1146 1.61e-07

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 52.36  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1024 ITFAEASVPAEfelhnvepnVTGVFARTEVRAFTKLGPLIGQPVQTGEVREGSDMKWIFEMCEAGADKSYLLCCDNPNAS 1103
Cdd:cd19196     5 VIIAQSSIPGA---------GLGVFSKTWIKEGTEMGPYTGRIVSPEDVDPCKNNNLMWEVFNEDGTVSHFIDASQENHR 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 442615836 1104 NWLRFVRPAPSYEERNVNLVSIDRQAYFVSCRDLRNGMELLYW 1146
Cdd:cd19196    76 SWMTFVNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVW 118
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 1031-1150 1.16e-06

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 50.71  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615836 1031 VPAEFELH--NVEPNVTGVFARTEVRAFTKLGPLIGQpvqtgEVREGSDMKWIFEMCEAGADKSYLLCCDNPNASNWLRF 1108
Cdd:cd19214    30 IPSEFELResNIPGTGLGIWTKRKIEVGEKFGPYVGE-----QRSNLKDPSYGWEVLDEFGNVKFCIDASQPDVGSWLKY 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 442615836 1109 VRPAPSYEERNVNLVSIDRQAYFVSCRDLRNGMELLYW--SDDC 1150
Cdd:cd19214   105 IRFAGCYDQHNLVACQINDQIFYRAVADIDPGEELLLFmkSEDY 148
2DBD_NR_DBD1 cd07157
The first DNA-binding domain (DBD) of the 2DBD nuclear receptors is composed of two C4-type ...
 1198-1268 8.06e-03

The first DNA-binding domain (DBD) of the 2DBD nuclear receptors is composed of two C4-type zinc fingers; The first DNA-binding domain (DBD) of the 2DBD nuclear receptors(NRs) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. NRs interact with specific DNA sites upstream of the target gene and modulate the rate of transcriptional initiation. Theses proteins contain two DBDs in tandem, probably resulted from an ancient recombination event. The 2DBD-NRs are found only in flatworm species, mollusks and arthropods. Their biological function is unknown.


Pssm-ID: 143532  Cd Length: 86  Bit Score: 37.85  E-value: 8.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442615836 1198 CKVCGEPvlgkdnimkhAAEKHdgKGAYQCQFCSKFFLRLNYLEMHRTYGCasnPNRSRPVCDFCGRKFCQ 1268
Cdd:cd07157     3 CQVCGEP----------AAGFH--HGAYVCEACKKFFMRSSNAISFTISEC---PNGGKCIIDKKNRTKCQ 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH