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Conserved domains on  [gi|442625199|ref|NP_001259873|]
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hattifattener, isoform B [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-344 4.15e-28

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.11  E-value: 4.15e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 103 NLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNlladvpvEALKVLGKLNLLDLSKNQLSHIPDDaFVGLTKLSTL 182
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKEL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 183 KLNDNNVTLASNAFRGLEQsLKNLNLKGTKQRKVPESIRGLKSLAFLDLSQNGIKELPGAggirvFDGLDALTALNLERN 262
Cdd:COG4886  142 DLSNNQLTDLPEPLGNLTN-LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP-----LGNLTNLEELDLSGN 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 263 LIQSIGEtafagvrktlsslsllnnllaefpigAVHSLKELRVLDIGFNLLTSLPEaaFRGNPGITLLALDGNPLSSVPE 342
Cdd:COG4886  216 QLTDLPE--------------------------PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP 267


                 ..
gi 442625199 343 GA 344
Cdd:COG4886  268 LA 269
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 332-413 3.35e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 44.69  E-value: 3.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199   332 LDGNPLSSVPEGAFAHLnATLRGLSLGGRFLHCDCKLRWVAEWIRngDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEEL 411
Cdd:TIGR00864    2 ISNNKISTIEEGICANL-CNLSEIDLSGNPFECDCGLARLPRWAE--EKGVKVRQPEAALCAGPGALAGQPLLGIPLLDS 78


                   ..
gi 442625199   412 SC 413
Cdd:TIGR00864   79 GC 80
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-344 4.15e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.11  E-value: 4.15e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 103 NLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNlladvpvEALKVLGKLNLLDLSKNQLSHIPDDaFVGLTKLSTL 182
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKEL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 183 KLNDNNVTLASNAFRGLEQsLKNLNLKGTKQRKVPESIRGLKSLAFLDLSQNGIKELPGAggirvFDGLDALTALNLERN 262
Cdd:COG4886  142 DLSNNQLTDLPEPLGNLTN-LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP-----LGNLTNLEELDLSGN 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 263 LIQSIGEtafagvrktlsslsllnnllaefpigAVHSLKELRVLDIGFNLLTSLPEaaFRGNPGITLLALDGNPLSSVPE 342
Cdd:COG4886  216 QLTDLPE--------------------------PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP 267


                 ..
gi 442625199 343 GA 344
Cdd:COG4886  268 LA 269
LRR_8 pfam13855
Leucine rich repeat;
131-189 1.56e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 1.56e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 442625199  131 LRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNV 189
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 39-238 5.80e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.91  E-value: 5.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199  39 RDVPDLQTSCICAYNLGR-ELSVQCdqvdfsqLLAAMNTHARLKPVDLlyvNNSTISELPDAVFSNL----SLHNLQLSS 113
Cdd:cd00116   48 RPQPSLKELCLSLNETGRiPRGLQS-------LLQGLTKGCGLQELDL---SDNALGPDGCGVLESLlrssSLQELKLNN 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 114 CGIQ----RIATGAFKGQESVLRNLNLQDNLLADVP--------------------------------VEALKVLGKLNL 157
Cdd:cd00116  118 NGLGdrglRLLAKGLKDLPPALEKLVLGRNRLEGAScealakalranrdlkelnlanngigdagiralAEGLKANCNLEV 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 158 LDLSKNQLSHIPDDAFVG----LTKLSTLKLNDNNVTLA-----SNAFRGLEQSLKNLNLKGTK-----QRKVPESIRGL 223
Cdd:cd00116  198 LDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTDAgaaalASALLSPNISLLTLSLSCNDitddgAKDLAEVLAEK 277

                        250
                 ....*....|....*
gi 442625199 224 KSLAFLDLSQNGIKE 238
Cdd:cd00116  278 ESLLELDLRGNKFGE 292
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 89-356 1.49e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199  89 NNSTISELPDAVF-SNLSLHNLQLSSCGIqriaTGAF-KGQESVLRNLNLQDNLLA-DVPVEaLKVLGKLNLLDLSKNQL 165
Cdd:PLN00113 102 NNQLSGPIPDDIFtTSSSLRYLNLSNNNF----TGSIpRGSIPNLETLDLSNNMLSgEIPND-IGSFSSLKVLDLGGNVL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 166 S-HIPddafVGLTKLSTLKLndnnVTLASNAFRG-----LEQsLKNL--------NLKGtkqrKVPESIRGLKSLAFLDL 231
Cdd:PLN00113 177 VgKIP----NSLTNLTSLEF----LTLASNQLVGqipreLGQ-MKSLkwiylgynNLSG----EIPYEIGGLTSLNHLDL 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 232 SQNGIK-ELPGAGGirvfdGLDALTALNLERN-LIQSIGETAFaGVRKTLSSLSLLNNLLAEFPiGAVHSLKELRVLDIG 309
Cdd:PLN00113 244 VYNNLTgPIPSSLG-----NLKNLQYLFLYQNkLSGPIPPSIF-SLQKLISLDLSDNSLSGEIP-ELVIQLQNLEILHLF 316

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 442625199 310 FNLLTSLPEAAFRGNPGITLLALDGNPLS-SVPEGAFAHLNATLRGLS 356
Cdd:PLN00113 317 SNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLS 364
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 332-413 3.35e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 44.69  E-value: 3.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199   332 LDGNPLSSVPEGAFAHLnATLRGLSLGGRFLHCDCKLRWVAEWIRngDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEEL 411
Cdd:TIGR00864    2 ISNNKISTIEEGICANL-CNLSEIDLSGNPFECDCGLARLPRWAE--EKGVKVRQPEAALCAGPGALAGQPLLGIPLLDS 78


                   ..
gi 442625199   412 SC 413
Cdd:TIGR00864   79 GC 80
LRRCT smart00082
Leucine rich repeat C-terminal domain;
362-414 4.12e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.25  E-value: 4.12e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 442625199   362 LHCDCKLRWVAEWIRngDLQVTSRERNPQfCGTPPRFRDRgFYSIQPEELSCP 414
Cdd:smart00082   3 FICDCELRWLLRWLQ--ANEHLQDPVDLR-CASPSSLRGP-LLELLHSEFKCP 51
LRR smart00370
Leucine-rich repeats, outliers;
300-323 4.68e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 4.68e-03
                           10        20
                   ....*....|....*....|....
gi 442625199   300 LKELRVLDIGFNLLTSLPEAAFRG 323
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-344 4.15e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.11  E-value: 4.15e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 103 NLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNlladvpvEALKVLGKLNLLDLSKNQLSHIPDDaFVGLTKLSTL 182
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKEL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 183 KLNDNNVTLASNAFRGLEQsLKNLNLKGTKQRKVPESIRGLKSLAFLDLSQNGIKELPGAggirvFDGLDALTALNLERN 262
Cdd:COG4886  142 DLSNNQLTDLPEPLGNLTN-LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP-----LGNLTNLEELDLSGN 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 263 LIQSIGEtafagvrktlsslsllnnllaefpigAVHSLKELRVLDIGFNLLTSLPEaaFRGNPGITLLALDGNPLSSVPE 342
Cdd:COG4886  216 QLTDLPE--------------------------PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP 267


                 ..
gi 442625199 343 GA 344
Cdd:COG4886  268 LA 269
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-357 2.31e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.94  E-value: 2.31e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199  66 DFSQLLAAMNTHARLKPVDLLYV-NNSTISELPDavfsnlsLHNLQLSSCGIQRIatGAFKGQESVLRNLNLQDNLLADV 144
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLsGNEELSNLTN-------LESLDLSGNQLTDL--PEELANLTNLKELDLSNNQLTDL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 145 PvEALKVLGKLNLLDLSKNQLSHIPDdAFVGLTKLSTLKLNDNNVTLASNAFRGLeQSLKNLNLKGTKQRKVPESIRGLK 224
Cdd:COG4886  152 P-EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNL-TNLEELDLSGNQLTDLPEPLANLT 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 225 SLAFLDLSQNGIKELPGaggirvFDGLDALTALNLERNLIQSIGETAfagvrktlsslsllnnllaefpigavhSLKELR 304
Cdd:COG4886  229 NLETLDLSNNQLTDLPE------LGNLTNLEELDLSNNQLTDLPPLA---------------------------NLTNLK 275

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 442625199 305 VLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNATLRGLSL 357
Cdd:COG4886  276 TLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-359 5.02e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.68  E-value: 5.02e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199  89 NNSTISELPDAVFSNLSLHNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSH- 167
Cdd:COG4886    4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLs 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 168 ---IPDDAFVGLTKLSTLKLNDNNvtlasnAFRGLeQSLKNLNLKGTKQRKVPESIRGLKSLAFLDLSQNGIKELPgagg 244
Cdd:COG4886   84 lllLGLTDLGDLTNLTELDLSGNE------ELSNL-TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP---- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 245 iRVFDGLDALTALNLERNLIQSIGEtafagvrktlsslsllnnllaefPIGavhSLKELRVLDIGFNLLTSLPEaAFRGN 324
Cdd:COG4886  153 -EPLGNLTNLKSLDLSNNQLTDLPE-----------------------ELG---NLTNLKELDLSNNQITDLPE-PLGNL 204

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 442625199 325 PGITLLALDGNPLSSVPEgAFAHLNAtLRGLSLGG 359
Cdd:COG4886  205 TNLEELDLSGNQLTDLPE-PLANLTN-LETLDLSN 237
LRR_8 pfam13855
Leucine rich repeat;
131-189 1.56e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 1.56e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 442625199  131 LRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNV 189
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-265 4.03e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 4.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199  86 LYVNNSTISELPDAVFSNLSLHNLQLSSCGIQRIaTGAFKGQESvLRNLNLQDNLLADVPveALKVLGKLNLLDLSKNQL 165
Cdd:COG4886  187 LDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL-PEPLANLTN-LETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 166 SHIPDDAfvGLTKLSTLKLNDNNVT---LASNAFRGLEQSLKNLNLKGTKQRKVPESIRGLKSLAFLDLSQNGIKELPGA 242
Cdd:COG4886  263 TDLPPLA--NLTNLKTLDLSNNQLTdlkLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340

                        170       180
                 ....*....|....*....|...
gi 442625199 243 GGIRVFDGLDALTALNLERNLIQ 265
Cdd:COG4886  341 ALSLSLLALLTLLLLLNLLSLLL 363
LRR_8 pfam13855
Leucine rich repeat;
154-212 5.57e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 5.57e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199  154 KLNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVT-LASNAFRGLEqSLKNLNLKGTK 212
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTtLSPGAFSGLP-SLRYLDLSGNR 60
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 39-238 5.80e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.91  E-value: 5.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199  39 RDVPDLQTSCICAYNLGR-ELSVQCdqvdfsqLLAAMNTHARLKPVDLlyvNNSTISELPDAVFSNL----SLHNLQLSS 113
Cdd:cd00116   48 RPQPSLKELCLSLNETGRiPRGLQS-------LLQGLTKGCGLQELDL---SDNALGPDGCGVLESLlrssSLQELKLNN 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 114 CGIQ----RIATGAFKGQESVLRNLNLQDNLLADVP--------------------------------VEALKVLGKLNL 157
Cdd:cd00116  118 NGLGdrglRLLAKGLKDLPPALEKLVLGRNRLEGAScealakalranrdlkelnlanngigdagiralAEGLKANCNLEV 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 158 LDLSKNQLSHIPDDAFVG----LTKLSTLKLNDNNVTLA-----SNAFRGLEQSLKNLNLKGTK-----QRKVPESIRGL 223
Cdd:cd00116  198 LDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTDAgaaalASALLSPNISLLTLSLSCNDitddgAKDLAEVLAEK 277

                        250
                 ....*....|....*
gi 442625199 224 KSLAFLDLSQNGIKE 238
Cdd:cd00116  278 ESLLELDLRGNKFGE 292
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 105-269 2.56e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 2.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 105 SLHNLQLSSCGIQRIatgafkGQESVLRNLN---LQDNLLADVpvEALKVLGKLNLLDLSKNQLSHIPDdaFVGLTKLST 181
Cdd:cd21340    3 RITHLYLNDKNITKI------DNLSLCKNLKvlyLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 182 LKLNDNNVTLASnafrGLEqSLKNLN-LKGTKQR-----KV---PESIRGL-KSLAFLDLSQNGIKELpgaggiRVFDGL 251
Cdd:cd21340   73 LYLGGNRISVVE----GLE-NLTNLEeLHIENQRlppgeKLtfdPRSLAALsNSLRVLNISGNNIDSL------EPLAPL 141

                        170
                 ....*....|....*...
gi 442625199 252 DALTALNLERNLIQSIGE 269
Cdd:cd21340  142 RNLEQLDASNNQISDLEE 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-263 4.57e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 4.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199  86 LYVNNSTISELPDAvFSNL-SLHNLQLSSCGIQRIAT-GAFKGqesvLRNLNLQDNLLADVPVEALkvLGKLNLLDLSKN 163
Cdd:COG4886  210 LDLSGNQLTDLPEP-LANLtNLETLDLSNNQLTDLPElGNLTN----LEELDLSNNQLTDLPPLAN--LTNLKTLDLSNN 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 164 QLSHIPDDAFVGLTKLSTLKLNDNNVTLASNAFRGLEQSLKNLNLKGTKQRKVPESIRGLKSLAFLDLSQNGIKELPGAG 243
Cdd:COG4886  283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362

                        170       180
                 ....*....|....*....|
gi 442625199 244 GIRVFDGLDALTALNLERNL 263
Cdd:COG4886  363 LTLLLTLGLLGLLEATLLTL 382
LRR_8 pfam13855
Leucine rich repeat;
254-337 6.50e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 6.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199  254 LTALNLERNLIQSIGETAFAGvrktlsslsllnnllaefpigavhsLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALD 333
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKG-------------------------LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 442625199  334 GNPL 337
Cdd:pfam13855  58 GNRL 61
LRR_8 pfam13855
Leucine rich repeat;
302-359 9.16e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 9.16e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 442625199  302 ELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSVPEGAFAHLNAtLRGLSLGG 359
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-LRYLDLSG 58
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 53-268 6.04e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.87  E-value: 6.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199  53 NLGRELSVQCDQVdFSQLLAAMNTHARLKPVDLLYVNNSTISELPDAVFSNLSLHNLQLSSCGI-----QRIATgAFKGQ 127
Cdd:COG5238  158 LLGLAARLGLLAA-ISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIgdegaEILAE-ALKGN 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 128 ESvLRNLNLQDNLLADVPV----EALKVLGKLNLLDLSKNQLSH----IPDDAFVGLTKLSTLKLNDNNVTLASnaFRGL 199
Cdd:COG5238  236 KS-LTTLDLSNNQIGDEGVialaEALKNNTTVETLYLSGNQIGAegaiALAKALQGNTTLTSLDLSVNRIGDEG--AIAL 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 200 EQSLKN------LNLKGTK-----QRKVPESIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIG 268
Cdd:COG5238  313 AEGLQGnktlhtLNLAYNGigaqgAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQG 392
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 89-356 1.49e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199  89 NNSTISELPDAVF-SNLSLHNLQLSSCGIqriaTGAF-KGQESVLRNLNLQDNLLA-DVPVEaLKVLGKLNLLDLSKNQL 165
Cdd:PLN00113 102 NNQLSGPIPDDIFtTSSSLRYLNLSNNNF----TGSIpRGSIPNLETLDLSNNMLSgEIPND-IGSFSSLKVLDLGGNVL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 166 S-HIPddafVGLTKLSTLKLndnnVTLASNAFRG-----LEQsLKNL--------NLKGtkqrKVPESIRGLKSLAFLDL 231
Cdd:PLN00113 177 VgKIP----NSLTNLTSLEF----LTLASNQLVGqipreLGQ-MKSLkwiylgynNLSG----EIPYEIGGLTSLNHLDL 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 232 SQNGIK-ELPGAGGirvfdGLDALTALNLERN-LIQSIGETAFaGVRKTLSSLSLLNNLLAEFPiGAVHSLKELRVLDIG 309
Cdd:PLN00113 244 VYNNLTgPIPSSLG-----NLKNLQYLFLYQNkLSGPIPPSIF-SLQKLISLDLSDNSLSGEIP-ELVIQLQNLEILHLF 316

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 442625199 310 FNLLTSLPEAAFRGNPGITLLALDGNPLS-SVPEGAFAHLNATLRGLS 356
Cdd:PLN00113 317 SNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLS 364
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 86-267 3.37e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 3.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199  86 LYVNNSTISELPD-AVFSNLS---LHNLQLSScgIQRIATgafkgqesvLRNLN---LQDNLLADVpvEALKVLGKLNLL 158
Cdd:cd21340    7 LYLNDKNITKIDNlSLCKNLKvlyLYDNKITK--IENLEF---------LTNLThlyLQNNQIEKI--ENLENLVNLKKL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 159 DLSKNQLSHIpdDAFVGLTKLSTLKLNDNNV------TLASNAFRGLEQSLKNLNLKGTKQRkVPESIRGLKSLAFLDLS 232
Cdd:cd21340   74 YLGGNRISVV--EGLENLTNLEELHIENQRLppgeklTFDPRSLAALSNSLRVLNISGNNID-SLEPLAPLRNLEQLDAS 150

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 442625199 233 QNGIKELPGAggIRVFDGLDALTALNLERNLIQSI 267
Cdd:cd21340  151 NNQISDLEEL--LDLLSSWPSLRELDLTGNPVCKK 183
LRR_8 pfam13855
Leucine rich repeat;
201-264 6.85e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 6.85e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442625199  201 QSLKNLNLKGTKQRKV-PESIRGLKSLAFLDLSQNGIKELPGaggiRVFDGLDALTALNLERNLI 264
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSP----GAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 86-209 1.52e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199  86 LYVNNSTISELpdavfSNL-SLHNLQ---LSScgiQRIATGA--FKGQESV------LRNLNLQDNLLADVpvEALKVLG 153
Cdd:cd21340   73 LYLGGNRISVV-----EGLeNLTNLEelhIEN---QRLPPGEklTFDPRSLaalsnsLRVLNISGNNIDSL--EPLAPLR 142

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442625199 154 KLNLLDLSKNQLSHIPD--DAFVGLTKLSTLKLNDNNVTLASNaFR----GLEQSLKNLNLK 209
Cdd:cd21340  143 NLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPK-YRdkiiLASKSLEVLDGK 203
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 168-274 1.62e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 45.23  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199  168 IPDDAFVGlTKLSTLKLNDNNVTLASNAFRGLeQSLKNLNLkgtkqrkvPESIRGLKSLAF-------LDLSQNgIKELp 240
Cdd:pfam13306   3 IGSYAFYN-CSLTSITIPSSLTSIGEYAFSNC-TSLKSITL--------PSSLTSIGSYAFyncsltsITIPSS-LTSI- 70

                          90       100       110
                  ....*....|....*....|....*....|....
gi 442625199  241 gagGIRVFDGLDALTALNLERNLiQSIGETAFAG 274
Cdd:pfam13306  71 ---GEYAFSNCSNLKSITLPSNL-TSIGSYAFSN 100
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
178-342 3.50e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 3.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 178 KLSTLKLNDNNV-TLASNafrgLEQSLKNLNLKGTKQRKVPESIRglKSLAFLDLSQNGIKELPgaggirvfDGL-DALT 255
Cdd:PRK15370 200 QITTLILDNNELkSLPEN----LQGNIKTLYANSNQLTSIPATLP--DTIQEMELSINRITELP--------ERLpSALQ 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 256 ALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVH------SLK--------ELRVLDIGFNLLTSLPEAAf 321
Cdd:PRK15370 266 SLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHlnvqsnSLTalpetlppGLKTLEAGENALTSLPASL- 344

                        170       180
                 ....*....|....*....|.
gi 442625199 322 rgNPGITLLALDGNPLSSVPE 342
Cdd:PRK15370 345 --PPELQVLDVSKNQITVLPE 363
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 127-359 1.07e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 127 QESVLRNLNLQDNLLA-DVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTKLSTL---KLNDNnvTLASNAFRGLEQS 202
Cdd:cd00116   54 KELCLSLNETGRIPRGlQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLRSSSLqelKLNNN--GLGDRGLRLLAKG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 203 LKNL------------NLKGTKQRKVPESIRGLKSLAFLDLSQNGIKElpgAGGIRVFDGLDA---LTALNLERNLIQSI 267
Cdd:cd00116  132 LKDLppaleklvlgrnRLEGASCEALAKALRANRDLKELNLANNGIGD---AGIRALAEGLKAncnLEVLDLNNNGLTDE 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 268 GETAFAGvrktlsslsllnnllaefpigAVHSLKELRVLDIGFNLLTSLPEAAFrgnpgitllaLDGNPlssvpegafaH 347
Cdd:cd00116  209 GASALAE---------------------TLASLKSLEVLNLGDNNLTDAGAAAL----------ASALL----------S 247

                        250
                 ....*....|..
gi 442625199 348 LNATLRGLSLGG 359
Cdd:cd00116  248 PNISLLTLSLSC 259
LRR_8 pfam13855
Leucine rich repeat;
221-313 2.03e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199  221 RGLKSLaflDLSQNGIKELPGAggirVFDGLDALTALNLERNLIQSIGETAFAGvrktlsslsllnnllaefpigavhsL 300
Cdd:pfam13855   1 PNLRSL---DLSNNRLTSLDDG----AFKGLSNLKVLDLSNNLLTTLSPGAFSG-------------------------L 48

                          90
                  ....*....|...
gi 442625199  301 KELRVLDIGFNLL 313
Cdd:pfam13855  49 PSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 332-413 3.35e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 44.69  E-value: 3.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199   332 LDGNPLSSVPEGAFAHLnATLRGLSLGGRFLHCDCKLRWVAEWIRngDLQVTSRERNPQFCGTPPRFRDRGFYSIQPEEL 411
Cdd:TIGR00864    2 ISNNKISTIEEGICANL-CNLSEIDLSGNPFECDCGLARLPRWAE--EKGVKVRQPEAALCAGPGALAGQPLLGIPLLDS 78


                   ..
gi 442625199   412 SC 413
Cdd:TIGR00864   79 GC 80
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 155-234 6.45e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 6.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 155 LNLLDLSKNQLS-HIPDDAFVGLTKLSTLKLNDNNVT---------------LASNAFR-------GLEQSLKNLNLKGT 211
Cdd:PLN00113  95 IQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgsiprgsipnletldLSNNMLSgeipndiGSFSSLKVLDLGGN 174

                         90       100
                 ....*....|....*....|....
gi 442625199 212 K-QRKVPESIRGLKSLAFLDLSQN 234
Cdd:PLN00113 175 VlVGKIPNSLTNLTSLEFLTLASN 198
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 90-198 2.93e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 38.68  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199   90 NSTISELPDAVFSNLSLHNLQLSScGIQRIATGAFKGQESvLRNLNLQDNlladvpvealkvlgklnlldlsknqLSHIP 169
Cdd:pfam13306  42 PSSLTSIGSYAFYNCSLTSITIPS-SLTSIGEYAFSNCSN-LKSITLPSN-------------------------LTSIG 94

                          90       100
                  ....*....|....*....|....*....
gi 442625199  170 DDAFVGlTKLSTLKLNDNNVTLASNAFRG 198
Cdd:pfam13306  95 SYAFSN-CSLKSITIPSSVTTIGSYAFSN 122
LRRCT smart00082
Leucine rich repeat C-terminal domain;
362-414 4.12e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.25  E-value: 4.12e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 442625199   362 LHCDCKLRWVAEWIRngDLQVTSRERNPQfCGTPPRFRDRgFYSIQPEELSCP 414
Cdd:smart00082   3 FICDCELRWLLRWLQ--ANEHLQDPVDLR-CASPSSLRGP-LLELLHSEFKCP 51
LRR smart00370
Leucine-rich repeats, outliers;
300-323 4.68e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 4.68e-03
                           10        20
                   ....*....|....*....|....
gi 442625199   300 LKELRVLDIGFNLLTSLPEAAFRG 323
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
300-323 4.68e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 4.68e-03
                           10        20
                   ....*....|....*....|....
gi 442625199   300 LKELRVLDIGFNLLTSLPEAAFRG 323
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 91-274 4.82e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 4.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199  91 STISELPDAVFSNLSLHNLQ---------LSSCGIQRIATGAFKGQ------ESVLRNLNLQDNLLADVPVEALKVLGKL 155
Cdd:PLN00113 422 SEFTKLPLVYFLDISNNNLQgrinsrkwdMPSLQMLSLARNKFFGGlpdsfgSKRLENLDLSRNQFSGAVPRKLGSLSEL 501

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625199 156 NLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVTlasnafrgleqslknlnlkgtkqRKVPESIRGLKSLAFLDLSQNG 235
Cdd:PLN00113 502 MQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS-----------------------GQIPASFSEMPVLSQLDLSQNQ 558

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 442625199 236 IK-ELPGAGGirvfdGLDALTALNLERNLIQ----------SIGETAFAG 274
Cdd:PLN00113 559 LSgEIPKNLG-----NVESLVQVNISHNHLHgslpstgaflAINASAVAG 603
LRR smart00370
Leucine-rich repeats, outliers;
152-173 7.57e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 7.57e-03
                           10        20
                   ....*....|....*....|..
gi 442625199   152 LGKLNLLDLSKNQLSHIPDDAF 173
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAF 22
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
152-173 7.57e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 7.57e-03
                           10        20
                   ....*....|....*....|..
gi 442625199   152 LGKLNLLDLSKNQLSHIPDDAF 173
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAF 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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