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Conserved domains on  [gi|442625274|ref|NP_001259887|]
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WD repeat domain 62, isoform H [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
406-719 8.71e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.51  E-value: 8.71e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  406 VTCSSDDTIRVWGLDgcTNNDIYRRNIYSKELLKIVYSDDELQFI---KDQGSSLFD----KAGNSSYDGRNGVRCIKIS 478
Cdd:COG2319    94 ASASADGTVRLWDLA--TGLLLRTLTGHTGAVRSVAFSPDGKTLAsgsADGTVRLWDlatgKLLRTLTGHSGAVTSVAFS 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  479 PELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEkieRKLLASASRDRLIHVFDVAQNyLLLQTLDDHSS 558
Cdd:COG2319   172 PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD---GKLLASGSADGTVRLWDLATG-KLLRTLTGHSG 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  559 SITSIKFVGAGlnfQMI-SCGADKSIMFRSFQGNIFMRgTNTSGKTTLYDMEVDSNAKHILTACQDRNVRVYGTQNAKQT 637
Cdd:COG2319   248 SVRSVAFSPDG---RLLaSGSADGTVRLWDLATGELLR-TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  638 KTFKGSHSDEGSLiklSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQ 717
Cdd:COG2319   324 RTLTGHTGAVRSV---AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                  ..
gi 442625274  718 VP 719
Cdd:COG2319   401 LA 402
WD40 COG2319
WD40 repeat [General function prediction only];
2-544 2.88e-21

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 2.88e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274    2 DAPDVGRIIRAPARRKRNDEQLMDRIKLKKVLGLTVCSNAALDVSPVSGLLAYPAG-CTVVLFNAKRQTQAYLVNTSRKA 80
Cdd:COG2319    43 AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274   81 FTSVAFSRCGRYVATGecGINPAIKVWELETpngslehcsgGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSqhDMIVNV 160
Cdd:COG2319   123 VRSVAFSPDGKTLASG--SADGTVRLWDLAT----------GKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  161 FDWRANLKMAS-NKISSKVAAVCFSEDGSYFVTVG-NRHVKYWYLEGGRkykdpiplmgrsaILGDLRDNDFCAVAcgkg 238
Cdd:COG2319   189 WDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASGSaDGTVRLWDLATGK-------------LLRTLTGHSGSVRS---- 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  239 icaestyaitrqghlVEFSSrrlldkwvqcrttnancicvNERFILVGCAESIIRIFNSATLEYVTTLPrthylgvdvaq 318
Cdd:COG2319   252 ---------------VAFSP--------------------DGRLLASGSADGTVRLWDLATGELLRTLT----------- 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  319 giqinhimsvpqqakfpdciamvfdeqrskvscvynDHSLYIWDLRdISRVGKShsflyhstciwgvetvpynverepsq 398
Cdd:COG2319   286 ------------------------------------GHSGGVNSVA-FSPDGKL-------------------------- 302

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  399 tlpeecFVTCSSDDTIRVWGLDGctnndiyrrniyskellkivysddelqfikdqGSSLFDKAGNSsydgrNGVRCIKIS 478
Cdd:COG2319   303 ------LASGSDDGTVRLWDLAT--------------------------------GKLLRTLTGHT-----GAVRSVAFS 339

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442625274  479 PELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKierKLLASASRDRLIHVFDVA 544
Cdd:COG2319   340 PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDG---RTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
406-719 8.71e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.51  E-value: 8.71e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  406 VTCSSDDTIRVWGLDgcTNNDIYRRNIYSKELLKIVYSDDELQFI---KDQGSSLFD----KAGNSSYDGRNGVRCIKIS 478
Cdd:COG2319    94 ASASADGTVRLWDLA--TGLLLRTLTGHTGAVRSVAFSPDGKTLAsgsADGTVRLWDlatgKLLRTLTGHSGAVTSVAFS 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  479 PELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEkieRKLLASASRDRLIHVFDVAQNyLLLQTLDDHSS 558
Cdd:COG2319   172 PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD---GKLLASGSADGTVRLWDLATG-KLLRTLTGHSG 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  559 SITSIKFVGAGlnfQMI-SCGADKSIMFRSFQGNIFMRgTNTSGKTTLYDMEVDSNAKHILTACQDRNVRVYGTQNAKQT 637
Cdd:COG2319   248 SVRSVAFSPDG---RLLaSGSADGTVRLWDLATGELLR-TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  638 KTFKGSHSDEGSLiklSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQ 717
Cdd:COG2319   324 RTLTGHTGAVRSV---AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                  ..
gi 442625274  718 VP 719
Cdd:COG2319   401 LA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 405-717 1.46e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.91  E-value: 1.46e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  405 FVTCSSDDTIRVWglDGCTNNDIYRRNIYSKELLKIVYSDDELQFI---KDQGSSLFDKAGN---SSYDG-RNGVRCIKI 477
Cdd:cd00200    24 LATGSGDGTIKVW--DLETGELLRTLKGHTGPVRDVAASADGTYLAsgsSDKTIRLWDLETGecvRTLTGhTSYVSSVAF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  478 SPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKierKLLASASRDRLIHVFDVAQNYlLLQTLDDHS 557
Cdd:cd00200   102 SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG---TFVASSSQDGTIKLWDLRTGK-CVATLTGHT 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  558 SSITSIKFVGAGlnfqmiscgadksimfrsfqgnifmrgtntsgkttlydmevdsnaKHILTACQDRNVRVYGTQNAKQT 637
Cdd:cd00200   178 GEVNSVAFSPDG---------------------------------------------EKLLSSSSDGTIKLWDLSTGKCL 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  638 KTFKGshsDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQ 717
Cdd:cd00200   213 GTLRG---HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
2-544 2.88e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 2.88e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274    2 DAPDVGRIIRAPARRKRNDEQLMDRIKLKKVLGLTVCSNAALDVSPVSGLLAYPAG-CTVVLFNAKRQTQAYLVNTSRKA 80
Cdd:COG2319    43 AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274   81 FTSVAFSRCGRYVATGecGINPAIKVWELETpngslehcsgGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSqhDMIVNV 160
Cdd:COG2319   123 VRSVAFSPDGKTLASG--SADGTVRLWDLAT----------GKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  161 FDWRANLKMAS-NKISSKVAAVCFSEDGSYFVTVG-NRHVKYWYLEGGRkykdpiplmgrsaILGDLRDNDFCAVAcgkg 238
Cdd:COG2319   189 WDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASGSaDGTVRLWDLATGK-------------LLRTLTGHSGSVRS---- 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  239 icaestyaitrqghlVEFSSrrlldkwvqcrttnancicvNERFILVGCAESIIRIFNSATLEYVTTLPrthylgvdvaq 318
Cdd:COG2319   252 ---------------VAFSP--------------------DGRLLASGSADGTVRLWDLATGELLRTLT----------- 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  319 giqinhimsvpqqakfpdciamvfdeqrskvscvynDHSLYIWDLRdISRVGKShsflyhstciwgvetvpynverepsq 398
Cdd:COG2319   286 ------------------------------------GHSGGVNSVA-FSPDGKL-------------------------- 302

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  399 tlpeecFVTCSSDDTIRVWGLDGctnndiyrrniyskellkivysddelqfikdqGSSLFDKAGNSsydgrNGVRCIKIS 478
Cdd:COG2319   303 ------LASGSDDGTVRLWDLAT--------------------------------GKLLRTLTGHT-----GAVRSVAFS 339

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442625274  479 PELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKierKLLASASRDRLIHVFDVA 544
Cdd:COG2319   340 PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDG---RTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 125-542 1.97e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 1.97e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  125 VAEFVDHKYAVTCVAFSPTGKYLVSVGSqhDMIVNVFDWRANLKMASNKI-SSKVAAVCFSEDGSYFVTVG-NRHVKYWY 202
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSG--DGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLASGSsDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  203 LEGGRKYkdpiplmgrsailgdlrdndfcavacgkgicaeSTYAitrqGHlvefssrrllDKWVQCrttnanCICVNERF 282
Cdd:cd00200    80 LETGECV---------------------------------RTLT----GH----------TSYVSS------VAFSPDGR 106

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  283 ILVGCAE-SIIRIFNSATLEYVTTLPrthylgvdvaqgiqiNHIMSVpqqakfpDCIAmvFDEQRSKVSCVYNDHSLYIW 361
Cdd:cd00200   107 ILSSSSRdKTIKVWDVETGKCLTTLR---------------GHTDWV-------NSVA--FSPDGTFVASSSQDGTIKLW 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  362 DLRDISRVgksHSFLYHSTCIWGVETVPynverepsqtlPEECFVTCSSDDTIRVWgldgctnndiyrrNIYSKELLKiv 441
Cdd:cd00200   163 DLRTGKCV---ATLTGHTGEVNSVAFSP-----------DGEKLLSSSSDGTIKLW-------------DLSTGKCLG-- 213

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  442 ysddelqfikdqgsslfdkagnsSYDG-RNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYS 520
Cdd:cd00200   214 -----------------------TLRGhENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                         410       420
                  ....*....|....*....|..
gi 442625274  521 NEKierKLLASASRDRLIHVFD 542
Cdd:cd00200   271 PDG---KRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 678-716 4.40e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 4.40e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442625274    678 SNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIW 716
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 122-162 2.11e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 2.11e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 442625274    122 GSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSqhDMIVNVFD 162
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
679-716 3.68e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 3.68e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 442625274   679 NECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIW 716
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
122-162 4.05e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 4.05e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 442625274   122 GSVVAEFVDHKYAVTCVAFSPTGKYLVSVGsqHDMIVNVFD 162
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGS--DDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
406-719 8.71e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.51  E-value: 8.71e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  406 VTCSSDDTIRVWGLDgcTNNDIYRRNIYSKELLKIVYSDDELQFI---KDQGSSLFD----KAGNSSYDGRNGVRCIKIS 478
Cdd:COG2319    94 ASASADGTVRLWDLA--TGLLLRTLTGHTGAVRSVAFSPDGKTLAsgsADGTVRLWDlatgKLLRTLTGHSGAVTSVAFS 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  479 PELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEkieRKLLASASRDRLIHVFDVAQNyLLLQTLDDHSS 558
Cdd:COG2319   172 PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD---GKLLASGSADGTVRLWDLATG-KLLRTLTGHSG 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  559 SITSIKFVGAGlnfQMI-SCGADKSIMFRSFQGNIFMRgTNTSGKTTLYDMEVDSNAKHILTACQDRNVRVYGTQNAKQT 637
Cdd:COG2319   248 SVRSVAFSPDG---RLLaSGSADGTVRLWDLATGELLR-TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  638 KTFKGSHSDEGSLiklSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQ 717
Cdd:COG2319   324 RTLTGHTGAVRSV---AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                  ..
gi 442625274  718 VP 719
Cdd:COG2319   401 LA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 405-717 1.46e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.91  E-value: 1.46e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  405 FVTCSSDDTIRVWglDGCTNNDIYRRNIYSKELLKIVYSDDELQFI---KDQGSSLFDKAGN---SSYDG-RNGVRCIKI 477
Cdd:cd00200    24 LATGSGDGTIKVW--DLETGELLRTLKGHTGPVRDVAASADGTYLAsgsSDKTIRLWDLETGecvRTLTGhTSYVSSVAF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  478 SPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKierKLLASASRDRLIHVFDVAQNYlLLQTLDDHS 557
Cdd:cd00200   102 SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG---TFVASSSQDGTIKLWDLRTGK-CVATLTGHT 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  558 SSITSIKFVGAGlnfqmiscgadksimfrsfqgnifmrgtntsgkttlydmevdsnaKHILTACQDRNVRVYGTQNAKQT 637
Cdd:cd00200   178 GEVNSVAFSPDG---------------------------------------------EKLLSSSSDGTIKLWDLSTGKCL 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  638 KTFKGshsDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQ 717
Cdd:cd00200   213 GTLRG---HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 469-718 3.23e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.75  E-value: 3.23e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  469 RNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEkieRKLLASASRDRLIHVFDVAQNYL 548
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASAD---GTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  549 LlQTLDDHSSSITSIKFVGAGlnfQMI-SCGADKSIM---FRSFQGNIFMRGTNTSGKTTLydmeVDSNAKHILTACQDR 624
Cdd:cd00200    86 V-RTLTGHTSYVSSVAFSPDG---RILsSSSRDKTIKvwdVETGKCLTTLRGHTDWVNSVA----FSPDGTFVASSSQDG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  625 NVRVYGTQNAKQTKTFKGsHSDEGSliKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHL 704
Cdd:cd00200   158 TIKLWDLRTGKCVATLTG-HTGEVN--SVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLL 234

                         250
                  ....*....|....
gi 442625274  705 ISASGDGCIFIWQV 718
Cdd:cd00200   235 ASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 503-716 1.68e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.75  E-value: 1.68e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  503 LLTTIEAHESEVLCLEYSNEKierKLLASASRDRLIHVFDVAQNyLLLQTLDDHSSSITSIKFVGAGLnfQMISCGADKS 582
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDG---KLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGT--YLASGSSDKT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  583 ImfrsfqgnifmRGTNTSGKTTLYDME--------VD-SNAKHILTAC-QDRNVRVYGTQNAKQTKTFKGsHSDegSLIK 652
Cdd:cd00200    75 I-----------RLWDLETGECVRTLTghtsyvssVAfSPDGRILSSSsRDKTIKVWDVETGKCLTTLRG-HTD--WVNS 140

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442625274  653 LSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIW 716
Cdd:cd00200   141 VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
468-754 1.08e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 1.08e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  468 GRNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNekiERKLLASASRDRLIHVFDVAQNy 547
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP---DGKTLASGSADGTVRLWDLATG- 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  548 LLLQTLDDHSSSITSIKFVGAGLnfQMISCGADKSIMFRSFQGNIFMRgTNTSGKTTLYDMEVDSNAKHILTACQDRNVR 627
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAFSPDGK--LLASGSDDGTVRLWDLATGKLLR-TLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  628 VYGTQNAKQTKTFKGshsDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISA 707
Cdd:COG2319   230 LWDLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASG 306

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 442625274  708 SGDGCIFIWQVPhdmivtmqarmSQQRLR--SGHAPLPRPLApISpPDG 754
Cdd:COG2319   307 SDDGTVRLWDLA-----------TGKLLRtlTGHTGAVRSVA-FS-PDG 342
WD40 COG2319
WD40 repeat [General function prediction only];
3-583 3.50e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 3.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274    3 APDVGRIIRAPARRKRNDEQLMDRIKLKKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLFNAKRQTQAYLVNTSRKAFT 82
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274   83 SVAFSRCGRYVATGecGINPAIKVWELETpngslehcsgGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHdmIVNVFD 162
Cdd:COG2319    83 SVAFSPDGRLLASA--SADGTVRLWDLAT----------GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--TVRLWD 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  163 WRANLKMAS-NKISSKVAAVCFSEDGSYFVTVG-NRHVKYWYLEGGRKYKdpiplmgrsailgdlrdndfcavacgkgic 240
Cdd:COG2319   149 LATGKLLRTlTGHSGAVTSVAFSPDGKLLASGSdDGTVRLWDLATGKLLR------------------------------ 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  241 aestyaiTRQGHlvefssrrllDKWVqcrttnaNCICV--NERFILVGCAESIIRIFNSATLEYVTTLPrthylgvdvaq 318
Cdd:COG2319   199 -------TLTGH----------TGAV-------RSVAFspDGKLLASGSADGTVRLWDLATGKLLRTLT----------- 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  319 giqinhimsvpqqakfpdciamvfdeqrskvscvynDHSLYIWDLrDISRVGkshsflyhstciwgvetvpynverepsQ 398
Cdd:COG2319   244 ------------------------------------GHSGSVRSV-AFSPDG---------------------------R 259

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  399 TLpeecfVTCSSDDTIRVWGLDGctnndiyrrniyskellkivysddelqfikdqGSSLFDKAGNSSydgrnGVRCIKIS 478
Cdd:COG2319   260 LL-----ASGSADGTVRLWDLAT--------------------------------GELLRTLTGHSG-----GVNSVAFS 297

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  479 PELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNekiERKLLASASRDRLIHVFDVAQNyLLLQTLDDHSS 558
Cdd:COG2319   298 PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP---DGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTG 373

                         570       580
                  ....*....|....*....|....*
gi 442625274  559 SITSIKFVGAGLnfQMISCGADKSI 583
Cdd:COG2319   374 AVTSVAFSPDGR--TLASGSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
2-544 2.88e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 2.88e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274    2 DAPDVGRIIRAPARRKRNDEQLMDRIKLKKVLGLTVCSNAALDVSPVSGLLAYPAG-CTVVLFNAKRQTQAYLVNTSRKA 80
Cdd:COG2319    43 AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274   81 FTSVAFSRCGRYVATGecGINPAIKVWELETpngslehcsgGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSqhDMIVNV 160
Cdd:COG2319   123 VRSVAFSPDGKTLASG--SADGTVRLWDLAT----------GKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  161 FDWRANLKMAS-NKISSKVAAVCFSEDGSYFVTVG-NRHVKYWYLEGGRkykdpiplmgrsaILGDLRDNDFCAVAcgkg 238
Cdd:COG2319   189 WDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASGSaDGTVRLWDLATGK-------------LLRTLTGHSGSVRS---- 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  239 icaestyaitrqghlVEFSSrrlldkwvqcrttnancicvNERFILVGCAESIIRIFNSATLEYVTTLPrthylgvdvaq 318
Cdd:COG2319   252 ---------------VAFSP--------------------DGRLLASGSADGTVRLWDLATGELLRTLT----------- 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  319 giqinhimsvpqqakfpdciamvfdeqrskvscvynDHSLYIWDLRdISRVGKShsflyhstciwgvetvpynverepsq 398
Cdd:COG2319   286 ------------------------------------GHSGGVNSVA-FSPDGKL-------------------------- 302

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  399 tlpeecFVTCSSDDTIRVWGLDGctnndiyrrniyskellkivysddelqfikdqGSSLFDKAGNSsydgrNGVRCIKIS 478
Cdd:COG2319   303 ------LASGSDDGTVRLWDLAT--------------------------------GKLLRTLTGHT-----GAVRSVAFS 339

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442625274  479 PELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKierKLLASASRDRLIHVFDVA 544
Cdd:COG2319   340 PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDG---RTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 125-542 1.97e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 1.97e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  125 VAEFVDHKYAVTCVAFSPTGKYLVSVGSqhDMIVNVFDWRANLKMASNKI-SSKVAAVCFSEDGSYFVTVG-NRHVKYWY 202
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSG--DGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLASGSsDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  203 LEGGRKYkdpiplmgrsailgdlrdndfcavacgkgicaeSTYAitrqGHlvefssrrllDKWVQCrttnanCICVNERF 282
Cdd:cd00200    80 LETGECV---------------------------------RTLT----GH----------TSYVSS------VAFSPDGR 106

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  283 ILVGCAE-SIIRIFNSATLEYVTTLPrthylgvdvaqgiqiNHIMSVpqqakfpDCIAmvFDEQRSKVSCVYNDHSLYIW 361
Cdd:cd00200   107 ILSSSSRdKTIKVWDVETGKCLTTLR---------------GHTDWV-------NSVA--FSPDGTFVASSSQDGTIKLW 162

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  362 DLRDISRVgksHSFLYHSTCIWGVETVPynverepsqtlPEECFVTCSSDDTIRVWgldgctnndiyrrNIYSKELLKiv 441
Cdd:cd00200   163 DLRTGKCV---ATLTGHTGEVNSVAFSP-----------DGEKLLSSSSDGTIKLW-------------DLSTGKCLG-- 213

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  442 ysddelqfikdqgsslfdkagnsSYDG-RNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYS 520
Cdd:cd00200   214 -----------------------TLRGhENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                         410       420
                  ....*....|....*....|..
gi 442625274  521 NEKierKLLASASRDRLIHVFD 542
Cdd:cd00200   271 PDG---KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
42-205 3.63e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.57  E-value: 3.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274   42 ALDVSPVSGLLAypAGC---TVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVATGecGINPAIKVWELETpngsleh 118
Cdd:COG2319   251 SVAFSPDGRLLA--SGSadgTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASG--SDDGTVRLWDLAT------- 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  119 csgGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSqhDMIVNVFDWRANLKMAS-NKISSKVAAVCFSEDGSYFVTVG-NR 196
Cdd:COG2319   320 ---GKLLRTLTGHTGAVRSVAFSPDGKTLASGSD--DGTVRLWDLATGELLRTlTGHTGAVTSVAFSPDGRTLASGSaDG 394


                  ....*....
gi 442625274  197 HVKYWYLEG 205
Cdd:COG2319   395 TVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 606-719 5.13e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 5.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  606 YDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFKGsHSdeGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARM 685
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-HT--GPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                          90       100       110
                  ....*....|....*....|....*....|....
gi 442625274  686 YGHSELVTGLKFTNDCRHLISASGDGCIFIWQVP 719
Cdd:cd00200    90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE 123
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-417 5.23e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 5.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274   42 ALDVSPVSGLLAypAGC---TVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVATgeCGINPAIKVWELETpngsleh 118
Cdd:cd00200    14 CVAFSPDGKLLA--TGSgdgTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLAS--GSSDKTIRLWDLET------- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  119 csgGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSqhDMIVNVFDWRAN-LKMASNKISSKVAAVCFSEDGSyFVTVG--N 195
Cdd:cd00200    83 ---GECVRTLTGHTSYVSSVAFSPDGRILSSSSR--DKTIKVWDVETGkCLTTLRGHTDWVNSVAFSPDGT-FVASSsqD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  196 RHVKYWYLEGGRKYKdpiplmgrsailgdlrdndfcavacgkgicaestyaiTRQGHlvefssrrllDKWVqcrttnaNC 275
Cdd:cd00200   157 GTIKLWDLRTGKCVA-------------------------------------TLTGH----------TGEV-------NS 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274  276 ICV--NERFILVGCAESIIRIFNSATLEYVTTLPRthylgvdvaqgiqinHIMSVpqqakfpdcIAMVFDEQRSKVSCVY 353
Cdd:cd00200   183 VAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG---------------HENGV---------NSVAFSPDGYLLASGS 238

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442625274  354 NDHSLYIWDLRDISRVgksHSFLYHSTCIWGVETVPYNverepsqtlpeECFVTCSSDDTIRVW 417
Cdd:cd00200   239 EDGTIRVWDLRTGECV---QTLSGHTNSVTSLAWSPDG-----------KRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-162 1.34e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 1.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625274   59 TVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVATgeCGINPAIKVWELETpngslehcsgGSVVAEFVDHKYAVTCV 138
Cdd:cd00200   200 TIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS--GSEDGTIRVWDLRT----------GECVQTLSGHTNSVTSL 267

                          90       100
                  ....*....|....*....|....
gi 442625274  139 AFSPTGKYLVSVGsqHDMIVNVFD 162
Cdd:cd00200   268 AWSPDGKRLASGS--ADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 678-716 4.40e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 4.40e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 442625274    678 SNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIW 716
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 122-162 2.11e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 2.11e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 442625274    122 GSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSqhDMIVNVFD 162
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
679-716 3.68e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 3.68e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 442625274   679 NECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIW 716
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
122-162 4.05e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 4.05e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 442625274   122 GSVVAEFVDHKYAVTCVAFSPTGKYLVSVGsqHDMIVNVFD 162
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGS--DDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 500-542 1.58e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 1.58e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 442625274    500 NLRLLTTIEAHESEVLCLEYSNEKierKLLASASRDRLIHVFD 542
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDG---KYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 681-721 2.59e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 2.59e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 442625274  681 CMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQVPHD 721
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG 41
WD40 pfam00400
WD domain, G-beta repeat;
502-542 4.88e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 4.88e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 442625274   502 RLLTTIEAHESEVLCLEYSNEkieRKLLASASRDRLIHVFD 542
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPD---GKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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