|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
24-462 |
2.31e-152 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 439.36 E-value: 2.31e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 24 LLTMLGFMLNYALRVNLTIAIVDMVRPNVTSAVNATLVgnstaanstaSPDGVDVYEERFPWDSYQTNFVLGCFFWGYIL 103
Cdd:cd17318 2 ILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTST----------DKDTLPVEAPEFDWSEKTQGIILSSFFYGYIL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 104 TELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAHINYVVLIVVRVVLGFMLGASWPAIHPVAAVWIPPMERSK-FMS 182
Cdd:cd17318 72 TQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRlTSI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 183 NMMASSLGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVyetpathprisaeerreieeaigtttskkrpsh 262
Cdd:cd17318 152 AYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV--------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 263 vpwgqllcsPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVASSYLADYLRKKGTLS 342
Cdd:cd17318 199 ---------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILS 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 343 TTATRKLFTTFALVIPGLLMIVQVFLGYDATWSVTIFSLALFAHGAVTAGYLGNGLDIAPNFGGTIFGLANTLSSFGGFL 422
Cdd:cd17318 270 TTTVRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGII 349
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 442625992 423 STSMVGALTYKDQSFHSWQIVFWILAATYISAAVVFAILG 462
Cdd:cd17318 350 SPLIVGAIVKNDQTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
22-462 |
5.76e-87 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 272.42 E-value: 5.76e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 22 LNLLTMLGFMLNYALRVNLTIAIVDMVRPNVTSAVNATLVGNSTAANSTASPDGVDVyeERFPWDSYQTNFVLGCFFWGY 101
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPEHSSSPSVEHNETG--KKYDWDAETQGWILGSFFYGY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 102 ILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAHINYVVLIVVRVVLGFMLGASWPAIHPVAAVWIPPMERSKFM 181
Cdd:cd17381 79 IITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 182 SNMMA-SSLGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVYetpathprisaeerreieeaigtttskkrp 260
Cdd:cd17381 159 TISYAgAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLVM------------------------------ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 261 shvpwgqllcspAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVASSYLADYLRKKGT 340
Cdd:cd17381 209 ------------PLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQN 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 341 LSTTATRKLFTTFALVIPGLLMIVQVFLGYDATWSVTIFSLALFAHGAVTAGYLGNGLDIAPNFGGTIFGLANTLSSFGG 420
Cdd:cd17381 277 FSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPG 356
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 442625992 421 FLSTSMVGALTyKDQSFHSWQIVFWILAATYISAAVVFAILG 462
Cdd:cd17381 357 MVGPVIAKSLT-HNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
19-477 |
9.90e-78 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 250.82 E-value: 9.90e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 19 RQVLNLLTMLGFMLNYALRVNLTIAIVDMVRPNVTSAVNATLVGNSTAANSTASPDGVDVYEERFPWDSYQTNFVLGCFF 98
Cdd:TIGR00894 7 STKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENELDNIKNPNFKWSGALQGLILSSHF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 99 WGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAHInyvvLIVVRVVLGFMLGASWPAIHPVAAVWIPPMERS 178
Cdd:TIGR00894 87 YGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGG----GIALVVFCRVIQGLAQGSVSPATHKIIVKWAPP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 179 KFMSNMMASSLGAA-----ITMPICGYLI-SVAGWASVFYLTGAVGLLWSLAWFTFVYETPATHPRISAEERREIEEAIG 252
Cdd:TIGR00894 163 KERSRLLGMSTSGFqlgtfIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQ 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 253 TTTSKKRPShVPWGQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVASSYLA 332
Cdd:TIGR00894 243 GQKGSTRQS-LPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 333 DYLRKKGTLSTTATRKLFTTFALVIPGLLMIVQVFLGYDATWSVTIFSLALFAHGAVTAGYLGNGLDIAPNFGGTIFGLA 412
Cdd:TIGR00894 322 DFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGIT 401
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442625992 413 NTLSSFGGFLSTSMVGaLTYKDQSFHSWQIVFWILAATYISAAVVFAILGSGELQPWNNPPERVR 477
Cdd:TIGR00894 402 GLPGFIGGLIASTLAG-NILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
24-462 |
3.68e-72 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 232.83 E-value: 3.68e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 24 LLTMLGFMLNYALRVNLTIAIVDMVrpnvtsavnatlvgnstaanstaspdgvdvyeERFPWDSYQTNFVLGCFFWGYIL 103
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMA--------------------------------KEFGWSKTDQGLVLSSFFWGYAL 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 104 TELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAHINYVVLIVVRVVLGFMLGASWPAIHPVAAVWIPPMERSKFMSN 183
Cdd:cd17380 50 TQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSI 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 184 MMA-SSLGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVyetpathprisaeerreieeaigtttskkrpsh 262
Cdd:cd17380 130 VTAgSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL--------------------------------- 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 263 vpwgqllcsPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILhFDIKQNGLFSSLPYLGKYVMAVASSYLADYLRKKGTlS 342
Cdd:cd17380 177 ---------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGW-T 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 343 TTATRKLFTTFALVIPGLLMIVQVFLgYDATWSVTIFSLALFAHGAVTAGYLGNGLDIAPNFGGTIFGLANTLSSFGGFL 422
Cdd:cd17380 246 VTSVRKLMQSIGFLGPALFLLLLSHT-DSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIV 324
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 442625992 423 STSMVGALTykdQSFHSWQIVFWILAATYISAAVVFAILG 462
Cdd:cd17380 325 GVYLTGYIL---EATGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
28-462 |
1.33e-67 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 221.83 E-value: 1.33e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 28 LGFMLNYALRVNLTIAIVDMVRpNVTSAVNATLVgnstaanstaspdgvdVYEERFPWDSYQTNFVLGCFFWGYILTELP 107
Cdd:cd17382 6 LGFCISFGIRCNLGVAIVRMVN-NFTDAYGGKVI----------------VHKAEFNWTPETVGLIESSFFWGYLVTQIP 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 108 GGRLAELIGGRRVFGHSMLWASLLTLITPLAAHINYVVLIVVRVVLGFMLGASWPAIHPVAAVWIPPMERSKFMSNMMA- 186
Cdd:cd17382 69 GGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCg 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 187 SSLGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFtfvyetpathprisaeerreieeaigtttskkrpshvpwg 266
Cdd:cd17382 149 SYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWM---------------------------------------- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 267 qLLCSPaVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVASSYLADYLRKKGTLSTTAT 346
Cdd:cd17382 189 -LVSMP-VYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAV 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 347 RKLFTTFALVIPGLLMIVQVFLgYDATWSVTIFSLALFAHGAVTAGYLGNGLDIAPNFGGTIFGLANTLSSFGGFLSTSM 426
Cdd:cd17382 267 RKIFNCGGFGMEATFLLVVAFS-HSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVI 345
|
410 420 430
....*....|....*....|....*....|....*.
gi 442625992 427 VGALTyKDQSFHSWQIVFWILAATYISAAVVFAILG 462
Cdd:cd17382 346 VGALT-KHKTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
24-461 |
5.52e-38 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 142.32 E-value: 5.52e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 24 LLTMLGFMLNYALRVNLTIAIVDMvrpnvtsavnatlvgnstaanstaspdgvdvyEERFPWDSYQTNFVLGCFFWGYIL 103
Cdd:cd17319 6 PLLFLAYVINYLDRVNISVAAPTI--------------------------------MKDLGLSPTQYGLIASAFFLGYAL 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 104 TELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAhiNYVVLIVVRVVLGFMLGASWPAIHPVAAVWIPPMERSKFMSN 183
Cdd:cd17319 54 FQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT--SLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGL 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 184 MMASS-LGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVyetpathprisaeerreieeaigtttskkrpsh 262
Cdd:cd17319 132 FNSGApLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL--------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 263 vpwgqllcsPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVASSYLADYLRKKgtls 342
Cdd:cd17319 179 ---------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG---- 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 343 ttaTRKLFttfaLVIPGLLMIVQVFLGY---DATWSVTIFSLALFAHGAVTAGYLGNGLDIAP-NFGGTIFGLANTLSSF 418
Cdd:cd17319 246 ---ARRLV----IIIGLLLAAVGLLLAYlttSPVVAVILLSLAGFGIGAASPVFWSLPADLLPgEAAATAGGLINSGGNL 318
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 442625992 419 GGFLSTSMVGALTykdQSFHSWQIVFWILAATYISAAVVFAIL 461
Cdd:cd17319 319 GGFVAPLLIGYLV---DATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
24-462 |
2.14e-35 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 135.38 E-value: 2.14e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 24 LLTMLGFMLNYALRVNLTIAIVDMvrpnvtsavnatlvgnstaanstaspdgvdvyEERFPWDSYQTNFVLGCFFWGYIL 103
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPL--------------------------------QADLGLSAAQLGLLASAFFLGYAL 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 104 TELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAhiNYVVLIVVRVVLGFMLGASWPAIHPVAAVWIPPMERSKFMS- 182
Cdd:COG2271 61 GQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGi 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 183 NMMASSLGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAwftfvyetpathprisaeerreieeaigtttskkrpsh 262
Cdd:COG2271 139 FNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL-------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 263 vpwgqllcspAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVASSYLADYLRKKgtls 342
Cdd:COG2271 181 ----------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR---- 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 343 ttatRKLFTTFALVIPGLLMIVQVFLGyDATWSVTIFSLALFAHGAVTAGYLGNGLDIAP-NFGGTIFGLANTLSSFGGF 421
Cdd:COG2271 247 ----RKLVLAIGLLLAALALLLLALLP-SPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGA 321
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 442625992 422 LSTSMVGALTykdqSFHSWQIVFWILAATYISAAVVFAILG 462
Cdd:COG2271 322 LGPLLVGYLL----DATGYQAAFLLLAALALLAALLALLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
81-461 |
2.25e-28 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 116.13 E-value: 2.25e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 81 ERFPWDSYQTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAahINYVVLIVVRVVLGFMLGAS 160
Cdd:COG2223 33 EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA--VSYWLLLLLGLLLGIGGGGS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 161 WPAIHPVAAVWIPPMERSKFMS-NMMASSLGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVYETPATHPRi 239
Cdd:COG2223 111 FAVGIALVSKWFPPDRRGLALGlAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAA- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 240 saeerreieeaigtttsKKRPSHVPWGQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYL 319
Cdd:COG2223 190 -----------------AAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFAL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 320 GKYVMAVASSYLADYLRKKGTlsttatrklfTTFALVIPGLLMIVQVFLGYDATWSVTIFSLALFAHGAVTAGYLGNGLD 399
Cdd:COG2223 253 LGALGRPLGGWLSDRIGGRRV----------LLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPD 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442625992 400 IAP-NFGGTIFGLANTLSSFGGFLSTSMVGALTykdQSFHSWQIVFWILAATYISAAVVFAIL 461
Cdd:COG2223 323 IFPtKNAGAVYGLVGAAGGLGGFLGPLLFGALL---DATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
85-424 |
8.44e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 107.89 E-value: 8.44e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 85 WDSYQTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLItpLAAHINYVVLIVVRVVLGFMLGASWPAI 164
Cdd:pfam07690 29 ISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL--LLFASSLWLLLVLRVLQGLGAGALFPAA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 165 HPVAAVWIPPMERSKFMS-NMMASSLGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVYETPATHPRisaee 243
Cdd:pfam07690 107 LALIADWFPPEERGRALGlVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPK----- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 244 rreieeaigTTTSKKRPSHVPWGQLLCSPAVWAIIIChGLAVFGFFTVVNQLPTFMsKILHFDIKQNGLFSSLPYLGKYV 323
Cdd:pfam07690 182 ---------PAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 324 MAVASSYLADYLRKKgtlsttatRKLFTTFALVIPGLLMIVQVFLGYDATWSVTIFSLALFAHGAVTAGYLGNGLDIAP- 402
Cdd:pfam07690 251 GRLLLGRLSDRLGRR--------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPk 322
|
330 340
....*....|....*....|..
gi 442625992 403 NFGGTIFGLANTLSSFGGFLST 424
Cdd:pfam07690 323 EERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
76-458 |
7.86e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 94.03 E-value: 7.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 76 VDVYEERFPWDSYQTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAhiNYVVLIVVRVVLGF 155
Cdd:cd06174 19 LPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP--SFWLLLLGRFLLGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 156 MLGASWPAIHPVAAVWIPPMERSKFMSNM-MASSLGAAITMPICGYLIS--VAGWASVFYLTGAVGLLWSLAWFTFVYET 232
Cdd:cd06174 97 GSGLIDPAVLALIADLFPERERGRALGLLqAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILLLLVVPDP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 233 PATHPRisaeerreieeaiGTTTSKKRPSHVPWGQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGL 312
Cdd:cd06174 177 PESARA-------------KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 313 FSSLPYLGKYVMAVASSYLADYLRKkgtlsttatRKLFTTFALVIPGLLMIVQVFLGYDATWSVTIFSLALFAHGAVTAG 392
Cdd:cd06174 244 LLSLFGLAGALGSLLLGLLSDRLIG---------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLS 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442625992 393 YLGNGLDIAPNFGGTIFGLANTLSSFGGFLSTSMVGALTYkdqSFHSWQIVFWILAATYISAAVVF 458
Cdd:cd06174 315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA---ATFGLTGAFLVLAVLLLLAAILL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
78-423 |
4.33e-20 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 91.57 E-value: 4.33e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 78 VYEERFPWDSYQTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAhiNYVVLIVVRVVLGFML 157
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARFLQGLGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 158 GASWPAIHPVAAVWIPPMERSKFMS-NMMASSLGAAITMPICGYLISVAGWASVFYLTGAVGLLwslAWFTFVYETPATH 236
Cdd:COG2814 113 GALFPAALALIADLVPPERRGRALGlLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALL---ALLLLLRLLPESR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 237 PRisaeerreieeaigtttsKKRPSHVPWGQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSL 316
Cdd:COG2814 190 PA------------------ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLAL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 317 PYLGKYVMAVASSYLADYLRKKGTlsttatrkLFTTFALVIPGLLMIVQVFLGYDATWSVTIFSLALFAHGAVTAGYLGN 396
Cdd:COG2814 252 FGLGGVLGALLAGRLADRFGRRRL--------LLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE 323
|
330 340
....*....|....*....|....*..
gi 442625992 397 GLDiaPNFGGTIFGLANTLSSFGGFLS 423
Cdd:COG2814 324 LAP--PEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
89-461 |
2.66e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 80.31 E-value: 2.66e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 89 QTNFVLGCFFWGYILTELPGGRLAELIGGRRVfghsMLWASLLTLITPLAAHI--NYVVLIVVRVVLGFMLGASWPAIHP 166
Cdd:cd17325 32 QIGLIVAAYALAQLLFSPPAGRLSDRFGRKRL----LLLGLLLLAVSTLLFAFatSYWQLLLARFLQGLASAAVWPAAMA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 167 VAAVWIPPMERSKFMS-NMMASSLGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVYETPATHPRisaeerr 245
Cdd:cd17325 108 LIADIAPPEERGRAMGiFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 246 eieeaigtTTSKKRPSHVPWGQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMA 325
Cdd:cd17325 181 --------RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQ 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 326 VASSYLADYLRKKGtlsttatrklfttfaLVIPGLLMIVQVFLGYDATWSVTIFSLALFAHGAVTAGYLGNGL----DIA 401
Cdd:cd17325 253 PPAGKLSDRIGRKP---------------LILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLallaDIV 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442625992 402 PNFG-GTIFGLANTLSSFGGFLSTSMVGALTykdqSFHSWQIVFWILAATYISAAVVFAIL 461
Cdd:cd17325 318 PPEGrGTAMGLFNTAFSLGMVLGPLLGGFLY----DAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
89-459 |
9.14e-14 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 72.66 E-value: 9.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 89 QTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLItpLAAHINYVVLIVVRVVLGFMLGASWPAIHPVA 168
Cdd:cd17475 32 QVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALL--MALVGSYPVLLVLLFLVGAGYGSVQPGGGRAI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 169 AVWIPPMERSKFMS-NMMASSLGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVYETPATHprisaeerrei 247
Cdd:cd17475 110 MRWFPPRERGLAMGiRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAAS----------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 248 eeaigTTTSKKRPSHVPWGQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVA 327
Cdd:cd17475 179 -----AATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 328 SSYLADYLRKKgtlsttaTRKLFTTFALVIPGLLMIVQVFLgYDATWSVTIFSLALFAhGAVTAGYLGNGL----DIAP- 402
Cdd:cd17475 254 LGRVSDRVFGG-------RRRPVLVITAAIAAAALLVLSLL-SPGTPLWLLVLLLILL-GLFAIGWNGLYLtlvaESAGp 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 442625992 403 NFGGTIFGLANTLSSFGGFLSTSMVGALtyKDQSfHSWQIVFWILAATYISAAVVFA 459
Cdd:cd17475 325 EQAGTALGLANTINFIGIAIGPPLFGLL--VDAT-HSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
89-459 |
2.12e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 71.43 E-value: 2.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 89 QTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAhiNYVVLIVVRVVLGFMLGASWPAIHPVA 168
Cdd:cd17324 35 QAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP--SFALLLLARALAGLAHGGFWAIAAAYA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 169 AVWIPPMERSKFMSNMMA-SSLGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVYETPATHPRisaeerrei 247
Cdd:cd17324 113 ADLVPPEKRGRAIGLVFSgLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG--------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 248 eeaigtttskKRPSHVPWGQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDikqnGLFSSLPYLGKYVMAVA 327
Cdd:cd17324 184 ----------SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFS----SSAIIGLLLLFGVAGVV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 328 SSYLADYLRKKGTlsttatrklfTTFALVIPGLLMIVQVFLGYDATWSVTIFSLALFAHGAVTAGYLGN---GLDIAPNF 404
Cdd:cd17324 250 GSPLAGRLADRGG----------RRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALqtrVLRLAPEA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 442625992 405 GGTIFGLaNTLSSFGGFLSTSMVGALTYKDqsfHSWQIVFWILAATYISAAVVFA 459
Cdd:cd17324 320 RGLASSL-YLAAYNLGGALGAALGGLVLDH---GGWAGVGWVGAALLLLALLLAL 370
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
89-463 |
1.17e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 63.33 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 89 QTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAhiNYVVLIVVRVVLGFMLGASWPAIHPVA 168
Cdd:COG0738 44 QAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAP--SYPLLLLALFLLGLGLGLLDVAANPYV 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 169 AVwIPPMERSKFMSNMMAS-SLGAAITMPICGYLISV---AGWASVFYLTGAVGLLWSLAWFTFVYETPATHPrisaeer 244
Cdd:COG0738 122 AA-LGPETAASRLNLLHAFfSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEE------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 245 reieeaigtttSKKRPSHVPWGQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVM 324
Cdd:COG0738 194 -----------EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 325 AVASSYLADYLRKKGTLSTTAtrklfttfALVIPGLLMIVqvfLGYDATWSVTIFSLALFAHGAVTAGYLGNGLDIAPNF 404
Cdd:COG0738 263 RFLGGFLLKRFGPVRLLRLSA--------LLAAVGLLLAL---LAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 442625992 405 GGTIFGLANTLSSFGGFLSTSMVGALTykdqSFHSWQIVFWILAATYIsAAVVFAILGS 463
Cdd:COG0738 332 TAAAVSAVLIMGIVGGAIGPPLIGFLA----DAFGLRAAFLVPLVCYL-LILLLALALK 385
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
81-430 |
1.60e-10 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 62.78 E-value: 1.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 81 ERFPWDSYQTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAHInyVVLIVVRVVLGFMLGAS 160
Cdd:TIGR00881 23 EEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL--WVMAALWALNGIFQGMG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 161 WPAIHPVAAVWIPPMERSKFMSNM-MASSLGAAITMPIcgYLISVA---GWASVFYLTGAVGLLWSLAWFTFVYETPATH 236
Cdd:TIGR00881 101 WPPCGRTVTKWFSRSERGTWVSFWnCSHNVGGGLLPPL--VLFGIAelySWHWVFIVPGIIAIIVSLICFLLLRDSPQSC 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 237 --PRISAEERREIEEAIGTTTSKKRPSHVPWGQLLCSPAVWAIIICHgLAVFGFFTVVNQ-LPTFMSKILHFDIKQNGLF 313
Cdd:TIGR00881 179 glPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGY-VFVYVVRTGILDwSPLYLTQEKGFSKEKASWA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 314 SSLPYLGKYVMAVASSYLADYLRKKGTLSTTATRKlfttfALVIPGLLMIVQVFLGYDATWSVTIFSLALFAHGAVT-AG 392
Cdd:TIGR00881 258 FTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFM-----ALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMlIG 332
|
330 340 350
....*....|....*....|....*....|....*...
gi 442625992 393 YLGNGLdIAPNFGGTIFGLANTLSSFGGFLSTSMVGAL 430
Cdd:TIGR00881 333 VIASEL-APKKAAGTAAGFVGFFAYLGGILAGLPLGYL 369
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
81-449 |
4.02e-10 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 61.52 E-value: 4.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 81 ERFPWDSYQTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLItpLAAHINYVVLIVVRVVLGFMLGAS 160
Cdd:cd17312 31 EEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIF--MGFSTSLWFFAVLWGLNGLFQSMG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 161 WPAIHPVAAVWIPPMERSKFMSNMMASS-LGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVYETPathpri 239
Cdd:cd17312 109 WPPCVKLLGNWFSKKERGTVYGIWSTSHnFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 240 saeerreieeaigtttskkrpshvpwgqllcsPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYL 319
Cdd:cd17312 183 --------------------------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEV 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 320 GKYVMAVASSYLADYLRKkgtlsttATRKLFTTFALVIPGLLMIVQVFLGYDATWSVTIFSLALFAHGAVTAGYLGNGLD 399
Cdd:cd17312 231 GGIAGTILAGLLSDKLFG-------GRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQ 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 442625992 400 IAP--NFGGTIFGLANTLSSFGGFLSTSMVGALTykDQSFHSWQIVFWILAA 449
Cdd:cd17312 304 DIGrkEAAGTATGFVGLFGYLGASLAGLPLGYII--DHYGWSTVFYFLISAA 353
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
89-430 |
1.44e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 59.90 E-value: 1.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 89 QTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAHINYVVLIVvrvvlgFM--LGASWPAIhp 166
Cdd:cd17320 35 AVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIAR------FLqgLGAAAGSV-- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 167 VAAVWI----PPMERSKFMSNMMAS-SLGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVYETPATHPRISA 241
Cdd:cd17320 107 VARAIVrdlySGAELAKIFSLLMMIlAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 242 EerreieeaigtttskkRPSHVPWGQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGK 321
Cdd:cd17320 187 L----------------SSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 322 YVMAVASSYLADYLRKKGTLsttatrkLFTTFALVIPGLLMIVQVFLGYDATWSVTI-FSLALFAHGAVTAGYLGNGLDI 400
Cdd:cd17320 251 ILGSLLNGRLVRRFGPRRLL-------RLGLLLLLAAALVLLLAALLGGLSLWPLVApLFLIFFGFGLIFPNATSLALEP 323
|
330 340 350
....*....|....*....|....*....|
gi 442625992 401 APNFGGTIFGLANTLSSFGGFLSTSMVGAL 430
Cdd:cd17320 324 FPHVAGTASALLGFLQFLIGALAGALVGLL 353
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
176-462 |
6.29e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 57.58 E-value: 6.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 176 ERSKFMS-NMMASSLGAAITMPICGYLISVaGWASVFYLTGAVGLLWSLAWFtFVYETPATHPRIsaeerreieeaigTT 254
Cdd:cd17473 121 ERAKMLGlQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVYLLALPVLILVLL-FLPEPARKSKSA-------------AS 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 255 TSKKRPSHVPWGqllcspAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVASSYLADY 334
Cdd:cd17473 186 PGAATAAALPWK------RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRR 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 335 LRKKGTlsttatrkLFTTFALVIPGLLMIvqvflgydATWSvtifSLALFAHGAVTAGyLGNGL-----------DIAPN 403
Cdd:cd17473 260 LGKRRL--------LAIGFALMALGFLLL--------ALAS----GLWVVLLGAILAG-LGFGLllptlnswamsLVPPE 318
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 442625992 404 FGGTIFGLANTLSSFGGFLSTSMVGALTykdQSFHSWQIVFWILAATYISAAVVFAILG 462
Cdd:cd17473 319 LRGRAMGIVTSAFFLGQFLSPLVLGPLV---NLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
154-463 |
1.67e-08 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 56.57 E-value: 1.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 154 GFMLGASWPAIHPVAAVWIPPMERSKFMSNMMASSLGAAITMPI-CGYLISVAGWASVFYLTGAVGLLWSLAWFTFVYET 232
Cdd:cd17343 102 GLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPIlATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNE 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 233 P--ATHPRISAEERREIEEAIGTTTSKkrpshvpWGQLLCSPAVWAIIICHgLAVFGFFTVV---NQLptFMSKILHFDI 307
Cdd:cd17343 182 PsdVGLNNIEEEESKGKKKKSPRGEST-------LKELLLSPFLWLLSLGY-LVVFGVKTAVtdwGQL--FLIQDKGQSA 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 308 KQNGLFSSLPYLGKYVMAVASSYLADYLRKKGTLSTTATRKLF--TTFALVIPGLLMIVQVFLGYDAT--WSVTI-FSLA 382
Cdd:cd17343 252 LTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNPRMPlaLVFMAGLTVSLHLFRVHITSDSSelFILLLgFLIG 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 383 LFAHGAVTA-GYLGNGlDIAPNFGGTIFGLANTLSSFGGFLS---TSMVGaltykdqSFHSWQIVFWILAATYISAAVVF 458
Cdd:cd17343 332 FSLYGPIAIfGVIANE-SAPSHLCGTSHAIVALAANVGGVLAglpFSYIA-------KHYDWRTAFLLLEILCAITVVIL 403
|
....*
gi 442625992 459 AILGS 463
Cdd:cd17343 404 FLLRN 408
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
80-229 |
8.19e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.12 E-value: 8.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 80 EERFPWDSYQTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAhiNYVVLIVVRVVLGFMLGA 159
Cdd:cd17325 227 AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGL 304
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442625992 160 SWPAIHPVAAVWIPPMERSKFMS-NMMASSLGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFV 229
Cdd:cd17325 305 VFPATLALLADIVPPEGRGTAMGlFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
184-462 |
2.06e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.95 E-value: 2.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 184 MMASSLGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVYETPATHPRisaeerreieeaigtttskkRPSHV 263
Cdd:COG2807 147 TAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAA--------------------APAAA 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 264 PWGQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKiLHFDIKQNGLFSSLPYLGKYVMAVASSYLADYLRKKGTLst 343
Cdd:COG2807 207 SLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPL-- 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 344 tatrkLFTTFALVIPGLLMIVQVFLGYDATWSVTI-------FSLALfahgAVTAGYLGNGLDIApnfggTIFGLANTLS 416
Cdd:COG2807 284 -----LLLLGLLGLAGLLGLLLAPGSLPWLWAVLLglgqgglFPLAL----TLIGLRARTPAEAA-----ALSGMAQSVG 349
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 442625992 417 SFGGFLSTSMVGALtyKDQSfHSWQIVFWILAATYISAAVVFAILG 462
Cdd:COG2807 350 YLLAALGPLLVGAL--HDAT-GSWTAALLLLAALAVLMLVAGLLAG 392
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
83-461 |
5.99e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 48.45 E-value: 5.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 83 FPWDSYQTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAhiNYVVLIVVRVVLGFMLGASWP 162
Cdd:cd17371 29 FGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ--NYWQLLILRALAGLGFGGEWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 163 AIHPVAAVWIPPMERSKFMSNMMA-SSLGAAITMPICGYLISVA----GWASVFYLTGAVGLLwslAWFT--FVYETPAt 235
Cdd:cd17371 107 AGAALMAEYVPARHRGKALGYVQSgWAVGWLLATLLAALLFPLLppeiAWRVLFLLGALPALL---VLFIrrFVKEPPQ- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 236 hprisaeerrEIEEAIGTTTSKKRPShvpwGQLLCSPAVWAIIICHGL----AVFGFFTVVNQLPTFMSKILHFDIKQNG 311
Cdd:cd17371 183 ----------WQAARAARRHFADRPS----LRELFSPPLLRTTLLASLlatgALGGYYGITTWLPSYLTGERGLSFEGSA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 312 LFSSLPYLGKYVMAVASSYLADYLRKkgtlsttatRKLFTTFALV-IPGLLMIVQVFLGYDATWsVTIFSLALFAHGAVt 390
Cdd:cd17371 249 GYLVVTILGGFLGYLAGGFLADRIGR---------RNNFALFALGsAISILLYFFLPLSPTLIL-ILGFPLGFFASGPF- 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442625992 391 aGYLGNGLDIA--PNFGGTIFGLANTLSSFGGFLSTSMVGALTykdqSFHSWQIVFWILAATYISAAVVFAIL 461
Cdd:cd17371 318 -SGMGAYLTELfpTAVRATAQGFCYNVGRIIGALFPFLVGFLA----TSGSLGTAIAVFAAVYYIAGLVLALL 385
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
108-457 |
6.23e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.37 E-value: 6.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 108 GGRLAELIGGRRVFGHSMLWASLLTLITPLAAhiNYVVLIVVRVVLGFMLGASWPAIHPVAAVWIPPMERSK-----FMS 182
Cdd:cd17316 56 FGYLGDRIGRKKALILTLLLFGLATLLIGLLP--TPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFalgllQSG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 183 NMMASSLGAAITMPICGYLISVAGWASVFYLtGAVGLLWSLAWFtfvyetpathprisaeerreieeaigtttskkrpsh 262
Cdd:cd17316 134 WALGALLAALVASLLIPLLSGDWGWRILFLI-GALPALLALLLR------------------------------------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 263 vpwgqllcsPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVASSYLADYLRKKgtls 342
Cdd:cd17316 177 ---------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRK---- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 343 ttatrKLFTTFALVIPGLLMIVQVFLGYDATWSVTIFSLALFAHGAVTAGYLGNGLDIAP-NFGGTIFGLANTLSSFGGF 421
Cdd:cd17316 244 -----KTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPtEVRATGVGLSYNLGRLGGG 318
|
330 340 350
....*....|....*....|....*....|....*.
gi 442625992 422 LSTSMVGALTykdQSFHSWQIVFWILAATYISAAVV 457
Cdd:cd17316 319 GAPPLIALLL---ASTGGTGVPALILALLAIVALIV 351
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
86-430 |
1.60e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 46.97 E-value: 1.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 86 DSYQTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAhiNYVVLIVVRVVLGFMLGASWPAIH 165
Cdd:TIGR00895 50 DPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALAT--NVTQLLILRFLAGLGLGGLMPNLN 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 166 PVAAVWIPPMERSKFMSNMMAS-SLGAAITMPICGYLISVAGWASVFYLTGAVGLLwsLAWFT--FVYET--------PA 234
Cdd:TIGR00895 128 ALVSEYAPKRFRGTAVGLMFCGyPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLL--LLLLLmrFLPESidflvskrPE 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 235 THPRISAEERREIEEAIGTTTSKKRPSHVPW---------GQLL-CSPAVWAIIIChglAVFGFFTVVNQLPTFMSKiLH 304
Cdd:TIGR00895 206 TVRRIVNAIAPQMQAEAQSALPEQKSTQGTKrsvfkalfqGKTArITVLLWLLYFM---LLVGVYFLTNWLPKLMVE-LG 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 305 FDIKQNGLFSSLPYLGKYVMAVASSYLADYLRKKGTLSttatrklfttFALVIPGLLMIVQVFLGYDATWSVTIFSLALF 384
Cdd:TIGR00895 282 FSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTAL----------LLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFF 351
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 442625992 385 AHGAVTAGYLGNGLDIAPNFGGTIFGLANTLSSFGGFLSTSMVGAL 430
Cdd:TIGR00895 352 VNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
89-220 |
3.83e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 45.65 E-value: 3.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 89 QTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAHINyvVLIVVRVVLGFMLGASWPAIHPVA 168
Cdd:cd17365 35 QLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVL--QLALLRFLTGLGLGAAMPNAITLV 112
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 442625992 169 AVWIPPMERSKFMSNMMAS-SLGAAITMPICGYLISVAGWASVFYLTGAVGLL 220
Cdd:cd17365 113 SEYAPARRRSLAVTLMFCGyPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLI 165
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
88-364 |
4.28e-05 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 45.70 E-value: 4.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 88 YQTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITplAAHINYVVLIVVRVVLGFMLGASWPAIHPV 167
Cdd:cd17327 41 NQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLT--AAVKNFGGLIALRFFLGLFESGVFPGFILY 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 168 AAVWIPPMERSK-----FMSNMMASSLGAAI-----TMPICGyliSVAGWASVFYLTGAVGLLWSLAWFTFVYETPATHP 237
Cdd:cd17327 119 LGMWYKREEQAKriaffYAAAGLGSIFGGLLaygvfKILGVG---GLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAW 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 238 RISAEERREIEEAIGTTTSKKRPSHVPWGQL---LCSPAVWAIIICHGLAVFGFFTVVNQLPTFMsKILHFDIKQNGLFS 314
Cdd:cd17327 196 FLTEEEKELAVERLRANQTGKGDQKFKWKQIkeaFKDPRTWLLFLFFFCSQITNNGISNFLPLIL-KSLGFYSLQTNLLS 274
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 442625992 315 SLPYLGKYVMAVASSYLADYLRKKGtlsttatrkLFTTFA--LVIPGLLMIV 364
Cdd:cd17327 275 VPIGALGAVSLLIAALLSDRFKKRG---------LFAIFAcvLALVGSIILL 317
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
86-292 |
1.10e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.03 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 86 DSYQTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAahINYVVLIVVRVVLGFMLGASWPAIH 165
Cdd:COG0477 47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA--PSPELLIAARALQGIGAGGLMPGAL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 166 PVAAVWIPPMERSKFMS-NMMASSLGAAITMPICGYLISVAGWASVFYLTGAVGLLwSLAWFTFVYETPATHPRISAEER 244
Cdd:COG0477 125 ALIAELFPARERGRALGlWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLL-ALVLRLRLPESRGLLLALLALAL 203
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 442625992 245 REIEEAIGTTTSKKRPSHVPWGQLLCSPAVWAIIICHGLAVFGFFTVV 292
Cdd:COG0477 204 AALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
176-461 |
1.16e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.48 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 176 ERSKFMS-NMMASSLGAAITmPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVYETPATHPRISaeerreieeaigtT 254
Cdd:cd17474 120 ERAKAMGlYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSS-------------A 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 255 TSKKRPSHvpwgqLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGkyvMAVASSYLADY 334
Cdd:cd17474 186 TKLRDLKK-----ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVL---LALGSLFVGRL 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 335 LRKKgtlsttATRKLFTTFALVIPGLLMIVqVFLGYDATWSVTIFSLALFAHGAVTAGYLGNGLDIAPNFG-GTIFGLAN 413
Cdd:cd17474 258 LKKR------FGARRILVIGLLLYALSLLL-LGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEErGTASSLYN 330
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 442625992 414 TLSSFGGFLSTSMVGALTykdqSFHSWQIVFWILAATYISAAVVFAIL 461
Cdd:cd17474 331 FVRFLGQAVGPLLFGLLL----EIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
93-461 |
1.40e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.14 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 93 VLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAH---INYVVLIVVRVVLGFMLGASWPAIHPVAA 169
Cdd:cd06173 39 VLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALlgsLSLWLLLVLAFLLGIASAFFGPARQALLP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 170 VWIPPMERSKFMS-NMMASSLGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVYETPATHPRISAEERREIE 248
Cdd:cd06173 119 ELVPKEQLVRANAlNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLR 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 249 EAIGTTTSkkrpshvpwgqllcSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVAS 328
Cdd:cd06173 199 EGLRYLRR--------------SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 329 SYLADYLRKKGTLSttatrklfttFALVIPGLLMIVQVFLGYdatWSVTIFSLALFAHGAVTAGYLGNGL---DIAPNFG 405
Cdd:cd06173 265 GRLSKRRRRGRLLL----------IGALLLGLALLVLGLSPS---LWLLLAALFLLGLAGGLFNVPLNTLlqlRVPDELR 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 442625992 406 GTIFGLANTLSSFGGFLSTSMVGALTykdqSFHSWQIVFWILAATYISAAVVFAIL 461
Cdd:cd06173 332 GRVFSVYNALNSGAMPLGALLAGLLA----DALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
92-431 |
1.49e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.12 E-value: 1.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 92 FVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAHInyVVLIVVRVVLGFMLGASWPAIHPVAAVW 171
Cdd:cd17489 35 LVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV--ALLLVLRLIHGIGWGAFTTAAATLVADI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 172 IPPMERSKFMS-NMMASSLGAAITMPICGYLISVAGWASVFYLTGAVGLLwSLAWFTFVYETPATHPRISaeerreieea 250
Cdd:cd17489 113 IPPSRRGEGIGyYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL-ALLLVFLVKDPPPVAAEEA---------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 251 igtttskkRPSHVPWGQLLcSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIkqnGLFSSLPYLGKYVMAVASSY 330
Cdd:cd17489 182 --------EAGTRAFRRLV-EKKVLPPALILFLASIAYGAISTFLPLYAAERGISNA---GLFFTVYAIALLLSRPFSGK 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 331 LADYLRKKGTLSTTAtrkLFTTFALVI------PGLLMIVQVFLG------YDATWSVTIFSLALFAHGAVTAGYLGnGL 398
Cdd:cd17489 250 LSDRKGPKTVIIPGL---LLLALGLLLlsfagsPWMLLLAAVLYGlgfgllFPALQALAVDLVPPHRRGAANGTFFI-FF 325
|
330 340 350
....*....|....*....|....*....|....
gi 442625992 399 DIAPNFGGTIFGLANTLSSFGG-FLSTSMVGALT 431
Cdd:cd17489 326 DLGIGLGGLLLGLVAELFGYRAmFLLAAVVVLLA 359
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
89-461 |
1.74e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.76 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 89 QTNFVLGCFFWGYILTELPGGRLAELIGGRRVfghsMLWASLLTLI--TPLAAHINYVVLIVVRVVLGFMLGASWPAIHP 166
Cdd:cd17329 36 IVGLVLALSAVAGIVASLIGGRLADRFGRKPV----MLAGLLLRALgfALLGFAHSPWLFAIALVLTGFGGGLFEPASEA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 167 VAAVWIPPMERSK-FMSNMMASSLGAAITMPICGYLISvagwASVFYLTGAVGLLWSLAWFTFVYETPATHPRisaeerr 245
Cdd:cd17329 112 MIADVTTPENRTRaFSLLYWAINLGVAIGPLLGGLLLL----YSFRLLFLAAAVLFLLAALVLLFLLPETRPK------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 246 eieeaigTTTSKKRPSHVPWGQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLpylgKYVMA 325
Cdd:cd17329 181 -------RRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLAL----NALLI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 326 VASSYLADYLRKKGTLsttatrklftTFALVIPGLLMIVQ-VFLGYDATWSVTIFSLALFAHGAVTAGYLGNGL--DIAP 402
Cdd:cd17329 250 VLLQFPVARLVERFRL----------RKILMIGILLFAIGfAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLvaALAP 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 403 NFG-GTIFGLANTLSSFGGFLSTSMVGALTykdqSFHSWQIVFWILAATYISAAVVFAIL 461
Cdd:cd17329 320 PDKrGSYMGFYALAWGLGRAIGPLVGGLLL----DLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
99-459 |
3.93e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 42.62 E-value: 3.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 99 WGYILTELPGGRLAELIGGRRVFGhsmlwASLLTLITPLAAHINYVVLIVVRVVLGFMLG---ASWPAIHPVAAVWIPP- 174
Cdd:cd17341 45 LAGALLRLPYGFLCDRFGGRRVFI-----ASLLLLLIPLLALALAVSSYWGLLVLGFLLGfagANFASGQPWASFWFPKe 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 175 MERSKFMSNMMASSLGAAIT---MPI----CGYLISVAGWASVFYLTGAVGLLWSLAWFTFVYETPathprisaeerrei 247
Cdd:cd17341 120 KIGGAAGGIAGAGNMGVAVSqllAPLiagaIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLP-------------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 248 eeaigTTTSKKRPSHVPWGQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVA 327
Cdd:cd17341 186 -----TGKASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPA 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 328 SSYLADYLRkkgtlsttATRKLFTTFALVipGLLMIVQVFLGYDATWSVTIFSLALFAHGAVTAgyLGNGL------DIA 401
Cdd:cd17341 261 GGWLSDRFG--------GRRRLWWLFIVM--TIGAALLSLSLPTSGTNLVLFLALFVALGLGAG--AGNGSvfrmvpFIF 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 442625992 402 PNFGGTIFGLANTLSSFGGFLSTSMVGALTykdQSFHSWQIVFWILAATYISAAVVFA 459
Cdd:cd17341 329 RRELGAVTGLVGAIGGLGGFFLPLLFGSSA---LMTGSGVGAFSLFGVLAVACTLLVW 383
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
85-233 |
4.05e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.55 E-value: 4.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 85 WDSYQTNFVLGCFFWGYILTELPGGRLAELIGGRRVFghSMLWASLLTLITPLAAHI--NYVVLIVVRVVLGFMLGASWP 162
Cdd:COG2271 213 LSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKL--VLAIGLLLAALALLLLALlpSPALAIALLFLAGFGLGGAFG 290
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442625992 163 AIHPVAAVWIPPMERSKFMS-NMMASSLGAAITMPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVYETP 233
Cdd:COG2271 291 LLWALAAELFPKKARGTASGlVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
277-482 |
1.07e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.25 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 277 IIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVASSYLADYLRKKGTLSTTAtrklfttfalv 356
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGL----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 357 ipGLLMIVQVFLGYDATWSVTIFSLAL--FAHGAVTAGYLGNGLDIAP-NFGGTIFGLANTLSSFGGFLSTSMVGALTyk 433
Cdd:pfam07690 70 --LLFALGLLLLLFASSLWLLLVLRVLqgLGAGALFPAALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLA-- 145
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 442625992 434 dqSFHSWQIVFWILAATYISAAVVFAILGSGELQPWNNPPERVRISDVT 482
Cdd:pfam07690 146 --SLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIV 192
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
176-460 |
1.65e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.66 E-value: 1.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 176 ERSKFMSNMMASSLGAAITMPICGYLI-------SVAGWASVFYLTGAVGLLWSLAWFTFVYETPathprisaeerreie 248
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLvaafggdAALGYRLTALIFAVLGLLAFLLTFFGTKERP--------------- 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 249 eaigTTTSKKRPSHVPWGQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVAS 328
Cdd:COG2211 209 ----VPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLW 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 329 SYLADYLRKKGTLsttatrklftTFALVIPGLLMIVQVFLGYDATWSVTIFS-LALFAHGAVTA------------GYLG 395
Cdd:COG2211 285 PRLAKRFGKKKAF----------IIGLLLAALGLLLLFFLGPGNLWLLLVLAaLAGIGLGAILVlpwamladvvdyDEWK 354
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442625992 396 NGLDIApnfgGTIFGLANTLSSFGGFLSTSMVGAL----TYKDQSFHSWQIVFWILAATYISAAVVFAI 460
Cdd:COG2211 355 TGRRRE----GLYFGIFTFAIKLGQALAGALAGLLlalfGYVAGAAQSPSALTGIRLLFFLLPAVLLLL 419
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
106-457 |
2.44e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.23 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 106 LPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAHInyvvliVVRVVLGFMLGASWPAIHPVA----AVWIPPMERSKFM 181
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSL------AFLIAARALQGIGAAAIMPASlaliAATFPGERRGRAL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 182 S-NMMASSLGAAITMPICGYLISVAGWASVFYLTGAVGLLwslawftfvyetpathprisaeerreieeaigtttskkrp 260
Cdd:cd17321 123 GlWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV---------------------------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 261 shvpwgQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVASSYLADYLRKkgt 340
Cdd:cd17321 163 ------ALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGP--- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 341 lsttatrKLFTTFALVIPGLLMIVQVFLGYDATWSVTIFSLALFAhgavtagyLGNGLDIAPNFG-----------GTIF 409
Cdd:cd17321 234 -------RLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLG--------LGLGLFATPLTNaalssvpkekaGAAS 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442625992 410 GLANTLSSFGGFLSTSMVGAL------------------TYKDQSF-HSWQIVFWILAATYISAAVV 457
Cdd:cd17321 299 GILNTARQLGGALGVALLGALltaglsanlgdsgvaallSAAAAAFaAGFHLAFLVAAALALLAALL 365
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
109-228 |
2.61e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.94 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 109 GRLAELIGGRRVFGHSMLWASLLTLitPLAAHINYVVLIVVRVVLGFMLGASWPAIHPVAAVWIPPMERSK-FMSNMMAS 187
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASALLYI--PQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRiFGYNQSFQ 338
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 442625992 188 SLGAAITmPICGYLISVA-GWASVFYLTG---AVGLLWSlaWFTF 228
Cdd:cd17391 339 YLGNVAG-PLLGSAIAAHfGYRAVFVVTAllvLLNAIWS--FIFL 380
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
185-457 |
3.76e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.52 E-value: 3.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 185 MASSLGAAITMPICGYLISVAGWASVFYLTGAV-GLLWSLAWFTFVYETPATHPrisaeerreIEEAIGTTTSKKRPSHV 263
Cdd:cd17353 134 AGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIfLIIIVIGAFLIRDPPKGWVP---------PGVDPLANNAENSPRDY 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 264 PWGQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVASSYLADYLRKKGTLSt 343
Cdd:cd17353 205 TPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLS- 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 344 tatrklfttFALVIPGLLMIVQVFLGYDATWSVTIFSLALFAHGAVTAGYLGNGLDI-APNFGGTIFGLANTLSSFGGFL 422
Cdd:cd17353 284 ---------IAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFfGTKNAGTNYGLLYTAKGVGGLI 354
|
250 260 270
....*....|....*....|....*....|....*
gi 442625992 423 STSMVGALTYkdqsFHSWQIVFWILAATYISAAVV 457
Cdd:cd17353 355 GPIIAAYVLY----TGGYNAAFIIAAALSLVALAL 385
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
94-220 |
4.00e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 39.56 E-value: 4.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 94 LGCFFWGYILTELPG----GRLAELIGGRRVFGHSMLWASLLTLITPLAAhiNYVVLIVVRVVLGFMLGASWPAIHPVAA 169
Cdd:PRK11551 52 MGWAFSAGILGLLPGallgGRLADRIGRKRILIVSVALFGLFSLATAQAW--DFPSLLVARLLTGVGLGGALPNLIALTS 129
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 442625992 170 VWIPPMERSKFMSNMMAS-SLGAAITMPICGYLISVAGWASVFYLTGAVGLL 220
Cdd:PRK11551 130 EAVGPRLRGTAVSLMYCGvPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLL 181
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
273-461 |
5.09e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.19 E-value: 5.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 273 AVWAIIICHGLAVFGFFTVVNQLPTfMSKILHFDIKQNGLFSSLPYLGKYVMAVASSYLADYLRKKGTLsttatrkLFTT 352
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL-------LLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625992 353 FALVIPGLLMIVqvflgydaTWSVTIFSLALFAHGAVTAGYLGNGLDIA-----PNFGGTIFGLANTLSSFGGFLSTSMV 427
Cdd:COG2814 83 LLFALGSLLCAL--------APSLWLLLAARFLQGLGAGALFPAALALIadlvpPERRGRALGLLGAGLGLGPALGPLLG 154
|
170 180 190
....*....|....*....|....*....|....
gi 442625992 428 GALTykdqSFHSWQIVFWILAATYISAAVVFAIL 461
Cdd:COG2814 155 GLLA----DLFGWRWVFLVNAVLALLALLLLLRL 184
|
|
| |
