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Conserved domains on  [gi|442626433|ref|NP_001260162|]
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uncharacterized protein Dmel_CG17378, isoform C [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SBF2 super family cl13732
Myotubularin protein; This domain family is found in eukaryotes, and is approximately 220 ...
 337-396 8.61e-03

Myotubularin protein; This domain family is found in eukaryotes, and is approximately 220 amino acids in length. The family is found in association with pfam02141, pfam03456, pfam03455. This family is the middle region of SBF2, a member of the myotubularin family. Myotubularin-related proteins have been suggested to work in phosphoinositide-mediated signalling events that may also convey control of myelination. Mutations of SBF2 are implicated in Charcot-Marie-Tooth disease.


The actual alignment was detected with superfamily member pfam12335:

Pssm-ID: 463536  Cd Length: 227  Bit Score: 38.06  E-value: 8.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626433  337 ALFECSECEDYGPAAVLMNLCFLFYHEVevpgCDPYREYLFSSLRQQPIWQQARFWNAIF 396
Cdd:pfam12335  90 ALQDCSSMDEYGVAAALLPLSTAFCRKL----CTGVIQFAYTCVQDHPVWKNQQFWEAAF 145
 
Name Accession Description Interval E-value
SBF2 pfam12335
Myotubularin protein; This domain family is found in eukaryotes, and is approximately 220 ...
 337-396 8.61e-03

Myotubularin protein; This domain family is found in eukaryotes, and is approximately 220 amino acids in length. The family is found in association with pfam02141, pfam03456, pfam03455. This family is the middle region of SBF2, a member of the myotubularin family. Myotubularin-related proteins have been suggested to work in phosphoinositide-mediated signalling events that may also convey control of myelination. Mutations of SBF2 are implicated in Charcot-Marie-Tooth disease.


Pssm-ID: 463536  Cd Length: 227  Bit Score: 38.06  E-value: 8.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626433  337 ALFECSECEDYGPAAVLMNLCFLFYHEVevpgCDPYREYLFSSLRQQPIWQQARFWNAIF 396
Cdd:pfam12335  90 ALQDCSSMDEYGVAAALLPLSTAFCRKL----CTGVIQFAYTCVQDHPVWKNQQFWEAAF 145
 
Name Accession Description Interval E-value
SBF2 pfam12335
Myotubularin protein; This domain family is found in eukaryotes, and is approximately 220 ...
 337-396 8.61e-03

Myotubularin protein; This domain family is found in eukaryotes, and is approximately 220 amino acids in length. The family is found in association with pfam02141, pfam03456, pfam03455. This family is the middle region of SBF2, a member of the myotubularin family. Myotubularin-related proteins have been suggested to work in phosphoinositide-mediated signalling events that may also convey control of myelination. Mutations of SBF2 are implicated in Charcot-Marie-Tooth disease.


Pssm-ID: 463536  Cd Length: 227  Bit Score: 38.06  E-value: 8.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626433  337 ALFECSECEDYGPAAVLMNLCFLFYHEVevpgCDPYREYLFSSLRQQPIWQQARFWNAIF 396
Cdd:pfam12335  90 ALQDCSSMDEYGVAAALLPLSTAFCRKL----CTGVIQFAYTCVQDHPVWKNQQFWEAAF 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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