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Conserved domains on  [gi|442627915|ref|NP_001260465|]
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UK114, isoform B [Drosophila melanogaster]

Protein Classification

RidA family protein( domain architecture ID 817)

RidA (reactive intermediate/imine deaminase A) family protein

PubMed:  25975565

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YjgF_YER057c_UK114_family super family cl10015
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 6-127 1.20e-53

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


The actual alignment was detected with superfamily member TIGR00004:

Pssm-ID: 447879  Cd Length: 124  Bit Score: 164.78  E-value: 1.20e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915    6 RKLISTANAAKPVAPYNQAVVADRTVYVSGCLGLDKDTMKLVPGGPTEQAQKALENLEAVLKAADSGVDKVIKNTVFLKD 85
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 442627915   86 LNDFGAVNEVYKRVFNKDFPARSCFQVAKLPMDALVEIECIA 127
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIA 122
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 6-127 1.20e-53

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 164.78  E-value: 1.20e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915    6 RKLISTANAAKPVAPYNQAVVADRTVYVSGCLGLDKDTMKLVPGGPTEQAQKALENLEAVLKAADSGVDKVIKNTVFLKD 85
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 442627915   86 LNDFGAVNEVYKRVFNKDFPARSCFQVAKLPMDALVEIECIA 127
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIA 122
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 6-127 2.79e-50

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 156.11  E-value: 2.79e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915   6 RKLISTaNAAKPVAPYNQAVVADRTVYVSGCLGLDKDTMKlVPGGPTEQAQKALENLEAVLKAADSGVDKVIKNTVFLKD 85
Cdd:COG0251    3 RELINP-PAPAPIGPYSQAVRVGNLVFVSGQVPLDPDTGE-LGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 442627915  86 LNDFGAVNEVYKRVFNKDFPARSCFQVAKLPMDALVEIECIA 127
Cdd:COG0251   81 MADFAAVNEVYAEYFGEGRPARTAVGVAALPKGALVEIEAIA 122
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 13-127 3.71e-45

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 143.21  E-value: 3.71e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915   13 NAAKPVAPYNQAVVADRTVYVSGCLGLDKDTMKLVPGGPTEQAQKALENLEAVLKAADSGVDKVIKNTVFLKDLNDFGAV 92
Cdd:pfam01042   1 NAPAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEV 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 442627915   93 NEVYKRVFNKD-FPARSCFQVAKLPMDALVEIECIA 127
Cdd:pfam01042  81 NEVYAEYFDADkAPARSAVGVAALPLGALVEIEAIA 116
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 21-127 4.65e-42

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 134.99  E-value: 4.65e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915  21 YNQAVVADRTVYVSGCLGLDKDTMkLVPGGPTEQAQKALENLEAVLKAADSGVDKVIKNTVFLKDLNDFGAVNEVYKRVF 100
Cdd:cd00448    1 YSQAVRVGNLVFVSGQIPLDPDGE-LVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFF 79

                         90       100
                 ....*....|....*....|....*...
gi 442627915 101 -NKDFPARSCFQVAKLPMDALVEIECIA 127
Cdd:cd00448   80 gEGPPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
5-131 3.87e-27

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 97.83  E-value: 3.87e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915   5 VRKLISTANAAKPVAPYNQAVVADRTVYVSGCLGLDKDTMKlVPGGPTEQAQKALENLEAVLKAADSGVDKVIKNTVFLK 84
Cdd:PRK11401   1 MKKIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGE-IPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFIT 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 442627915  85 DLNDFGAVNEVYKRVFNK---DFPARSCFQVAKLPMDALVEIECIALTGS 131
Cdd:PRK11401  80 DLNDFATINEVYKQFFDEhqaTYPTRSCVQVARLPKDVKLEIEAIAVRSA 129
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 6-127 1.20e-53

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 164.78  E-value: 1.20e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915    6 RKLISTANAAKPVAPYNQAVVADRTVYVSGCLGLDKDTMKLVPGGPTEQAQKALENLEAVLKAADSGVDKVIKNTVFLKD 85
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 442627915   86 LNDFGAVNEVYKRVFNKDFPARSCFQVAKLPMDALVEIECIA 127
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIA 122
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 6-127 2.79e-50

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 156.11  E-value: 2.79e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915   6 RKLISTaNAAKPVAPYNQAVVADRTVYVSGCLGLDKDTMKlVPGGPTEQAQKALENLEAVLKAADSGVDKVIKNTVFLKD 85
Cdd:COG0251    3 RELINP-PAPAPIGPYSQAVRVGNLVFVSGQVPLDPDTGE-LGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYLTD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 442627915  86 LNDFGAVNEVYKRVFNKDFPARSCFQVAKLPMDALVEIECIA 127
Cdd:COG0251   81 MADFAAVNEVYAEYFGEGRPARTAVGVAALPKGALVEIEAIA 122
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 13-127 3.71e-45

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 143.21  E-value: 3.71e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915   13 NAAKPVAPYNQAVVADRTVYVSGCLGLDKDTMKLVPGGPTEQAQKALENLEAVLKAADSGVDKVIKNTVFLKDLNDFGAV 92
Cdd:pfam01042   1 NAPAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEV 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 442627915   93 NEVYKRVFNKD-FPARSCFQVAKLPMDALVEIECIA 127
Cdd:pfam01042  81 NEVYAEYFDADkAPARSAVGVAALPLGALVEIEAIA 116
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 21-127 4.65e-42

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 134.99  E-value: 4.65e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915  21 YNQAVVADRTVYVSGCLGLDKDTMkLVPGGPTEQAQKALENLEAVLKAADSGVDKVIKNTVFLKDLNDFGAVNEVYKRVF 100
Cdd:cd00448    1 YSQAVRVGNLVFVSGQIPLDPDGE-LVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFF 79

                         90       100
                 ....*....|....*....|....*...
gi 442627915 101 -NKDFPARSCFQVAKLPMDALVEIECIA 127
Cdd:cd00448   80 gEGPPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
5-131 3.87e-27

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 97.83  E-value: 3.87e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915   5 VRKLISTANAAKPVAPYNQAVVADRTVYVSGCLGLDKDTMKlVPGGPTEQAQKALENLEAVLKAADSGVDKVIKNTVFLK 84
Cdd:PRK11401   1 MKKIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGE-IPADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFIT 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 442627915  85 DLNDFGAVNEVYKRVFNK---DFPARSCFQVAKLPMDALVEIECIALTGS 131
Cdd:PRK11401  80 DLNDFATINEVYKQFFDEhqaTYPTRSCVQVARLPKDVKLEIEAIAVRSA 129
YjgF_YER057c_UK114_like_6 cd06154
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 9-127 3.11e-22

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100011  Cd Length: 119  Bit Score: 84.91  E-value: 3.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915   9 ISTANAAKPVAPYNQAVVADRTVYVSGCLGLDKDTMkLVPGGPTEQAQKALENLEAVLKAADSGVDKVIKNTVFLKDLND 88
Cdd:cd06154    1 ISSGSPWEEQAGYSRAVRVGNWVFVSGTTGYDYDGM-VMPGDAYEQTRQCLEIIEAALAEAGASLEDVVRTRMYVTDIAD 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 442627915  89 FGAVNEVYKRVFNKDFPARSCFQVAKLPMD-ALVEIECIA 127
Cdd:cd06154   80 FEAVGRAHGEVFGDIRPAATMVVVSLLVDPeMLVEIEVTA 119
YjgF_YER057c_UK114_like_2 cd06150
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 21-127 1.84e-17

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100007  Cd Length: 105  Bit Score: 72.18  E-value: 1.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915  21 YNQAVVADRTVYVSGCLGLDkdtmklVPGGPTEQAQKALENLEAVLKAADSGVDKVIKNTVFLKDLNDFGAVNEVYKRVF 100
Cdd:cd06150    3 MSQAVVHNGTVYLAGQVADD------TSADITGQTRQVLAKIDALLAEAGSDKSRILSATIWLADMADFAAMNAVWDAWV 76

                         90       100
                 ....*....|....*....|....*...
gi 442627915 101 NKDF-PARSCFQVAKLPMDALVEIECIA 127
Cdd:cd06150   77 PPGHaPARACVEAKLADPGYLVEIVVTA 104
YjgH_like cd02198
YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, ...
 21-127 6.26e-16

YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100005  Cd Length: 111  Bit Score: 68.44  E-value: 6.26e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915  21 YNQAVVADRTVYVSGCLGLDKDTMklVPGGPTEQAQKALENLEAVLKAADSGVDKVIKNTVFLKDL-NDFGAVNEVYKRV 99
Cdd:cd02198    3 YSPAVRVGDTLFVSGQVGSDADGS--VAEDFEAQFRLAFQNLGAVLEAAGCSFDDVVELTTFHVDMaAHLPAFAAVKDEY 80

                         90       100
                 ....*....|....*....|....*....
gi 442627915 100 FNKDFPARSCFQVAKLPMDA-LVEIECIA 127
Cdd:cd02198   81 FKEPYPAWTAVGVAWLARPGlLVEIKVVA 109
eu_AANH_C_2 cd06156
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 21-127 5.66e-12

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100013  Cd Length: 118  Bit Score: 58.49  E-value: 5.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915  21 YNQAVVADRTVYVSGCLGLDKDTMKLVPGGPTEQAQKALENLEAVLKAAdsGVDKVIKNTVFLKDLNDFGAVNEVYKRvF 100
Cdd:cd06156    1 YSQAIVVPKVAYISGQIGLIPATMTLLEGGITLQAVLSLQHLERVAKAM--NVQWVLAAVCYVTDESSVPIARSAWSK-Y 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 442627915 101 NKDFPARS--------------CFQVAKLPMDALVEIECIA 127
Cdd:cd06156   78 CSELDLEDesrnesddvnpplvIVVVPELPRGALVEWQGIA 118
eu_AANH_C_1 cd06155
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 53-128 2.23e-11

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100012  Cd Length: 101  Bit Score: 56.50  E-value: 2.23e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442627915  53 EQAQKALENLEAVLKAADSGVDKVIKNTVFLKDLNDFGAVNEVYKRVFnkDF---PARSCFQvAKLPMDALVEIECIAL 128
Cdd:cd06155   26 EQMESIFSKLREILQSNGLSLSDILYVTLYLRDMSDFAEVNSVYGTFF--DKpnpPSRVCVE-CGLPEGCDVQLSCVAA 101
YjgF_YER057c_UK114_like_4 cd06152
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 21-127 2.40e-10

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100009  Cd Length: 114  Bit Score: 54.23  E-value: 2.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915  21 YNQAV-VADRtVYVSGCLGLDKDTMKlVPGGPTEQAQKALENLEAVLKAAD-SGVDKVIKNTVFLKDLND---FGAVNEV 95
Cdd:cd06152    3 YSQAVrIGDR-IEISGQGGWDPDTGK-IPEDLEEEIDQAFDNVELALKAAGgKGWEQVYKVNSYHVDIKNeeaFGLMVEN 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 442627915  96 YKRVFNKDFPARSCFQVAKLPMDAL-VEIECIA 127
Cdd:cd06152   81 FKKWMPNHQPIWTCVGVTALGLPGMrVEIEVDA 113
YjgF_YER057c_UK114_like_1 cd02199
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 14-127 3.90e-10

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100006  Cd Length: 142  Bit Score: 54.00  E-value: 3.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915  14 AAKPVAPYNQAVVADRTVYVSGCLGLDKDTMKL---VPGGPT-EQAQKALE----NLEAVLKAA---DSGVDKVIKNTVF 82
Cdd:cd02199    9 APAPVGNYVPAVRTGNLLYVSGQLPRVDGKLVYtgkVGADLSvEEGQEAARlcalNALAALKAAlgdLDRVKRVVRLTGF 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 442627915  83 LKDLNDFGA----VN---EVYKRVFNKD-FPARSCFQVAKLPMDALVEIECIA 127
Cdd:cd02199   89 VNSAPDFTEqpkvANgasDLLVEVFGEAgRHARSAVGVASLPLNAAVEVEAIV 141
YjgF_YER057c_UK114_like_3 cd06151
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 29-127 7.21e-09

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100008  Cd Length: 126  Bit Score: 50.40  E-value: 7.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915  29 RTVYVSGCLG--LDKDTMKLVP---GGPTEQAQKALENLEAVLKAADSGVDKVIKNTVFL----KDLN--DFGAVNEVYK 97
Cdd:cd06151   12 ATIYLSGTVPavVNASAPKGSParyGDTETQTISVLKRIETILQSQGLTMGDVVKMRVFLvadpALDGkmDFAGFMKAYR 91

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 442627915  98 RVFNKD----FPARSCFQVAKLPM-DALVEIECIA 127
Cdd:cd06151   92 QFFGTAeqpnKPARSTLQVAGLVNpGWLVEIEVVA 126
YjgF_YER057c_UK114_like_5 cd06153
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 27-127 5.45e-07

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100010  Cd Length: 114  Bit Score: 45.33  E-value: 5.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627915  27 ADRTVYVSGCLGLD-KDTMklVPGGPTEQAQKALENLEAVLKAAD-----SGVDKVIKNTVFLKDLNDFGAVNEVYKRVF 100
Cdd:cd06153   11 GRTHLFISGTASIVgHGTV--HPGDVEAQTRETLENIEALLEAAGrgggaQFLADLLRLKVYLRDREDLPAVRAILAARL 88

                         90       100
                 ....*....|....*....|....*..
gi 442627915 101 NKDFPArSCFQVAKLPMDALVEIECIA 127
Cdd:cd06153   89 GPAVPA-VFLQADVCRPDLLVEIEAVA 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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