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Conserved domains on  [gi|442627992|ref|NP_001260489|]
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endonuclease G inhibitor, isoform B [Drosophila melanogaster]

Protein Classification

Ku_PK_bind superfamily-containing protein( domain architecture ID 16535)

Ku_PK_bind superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ku_PK_bind super family cl07408
Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by ...
 31-138 2.12e-07

Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired. Ku is a component of a multi-protein complex that is involved in the NHEJ. Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). This domain is found at the C terminal of Ku which binds to DNA-PKcs.


The actual alignment was detected with superfamily member pfam08785:

Pssm-ID: 462604  Cd Length: 117  Bit Score: 49.12  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627992   31 DPVKDYQKLIETRVQVDEIvdDDVTKEnfdrtaaaARDVIWRLLFDeaGTSQSNTEKASQLLEEYRgDAC--FYDPTPYN 108
Cdd:pfam08785   1 NPVPDFKQLLARGDDVDAV--EKAVKQ--------MGNIIEDLVRD--SFGDSNYDKALECLRALR-EECieEEEPDLYN 67

                          90       100       110
                  ....*....|....*....|....*....|
gi 442627992  109 EWIVKLRDEVLKKELLDFWrDVLVKKQLGP 138
Cdd:pfam08785  68 DFLRDLKKKLLEGDRREFW-ELVRKNKLGL 96
Ku_PK_bind super family cl07408
Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by ...
 217-323 1.28e-03

Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired. Ku is a component of a multi-protein complex that is involved in the NHEJ. Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). This domain is found at the C terminal of Ku which binds to DNA-PKcs.


The actual alignment was detected with superfamily member pfam08785:

Pssm-ID: 462604  Cd Length: 117  Bit Score: 38.34  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627992  217 NPLEEYRTLMKRfvltkiivPDSVHQasVKKIAAAAREIIWKLLFDgtpSAEDQN--KAAELLQEYKGDA-GFYGPDDYN 293
Cdd:pfam08785   1 NPVPDFKQLLAR--------GDDVDA--VEKAVKQMGNIIEDLVRD---SFGDSNydKALECLRALREECiEEEEPDLYN 67

                          90       100       110
                  ....*....|....*....|....*....|
gi 442627992  294 SWIFNLRDEVLTKELLDFWrDKMVKMELGP 323
Cdd:pfam08785  68 DFLRDLKKKLLEGDRREFW-ELVRKNKLGL 96
 
Name Accession Description Interval E-value
Ku_PK_bind pfam08785
Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by ...
 31-138 2.12e-07

Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired. Ku is a component of a multi-protein complex that is involved in the NHEJ. Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). This domain is found at the C terminal of Ku which binds to DNA-PKcs.


Pssm-ID: 462604  Cd Length: 117  Bit Score: 49.12  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627992   31 DPVKDYQKLIETRVQVDEIvdDDVTKEnfdrtaaaARDVIWRLLFDeaGTSQSNTEKASQLLEEYRgDAC--FYDPTPYN 108
Cdd:pfam08785   1 NPVPDFKQLLARGDDVDAV--EKAVKQ--------MGNIIEDLVRD--SFGDSNYDKALECLRALR-EECieEEEPDLYN 67

                          90       100       110
                  ....*....|....*....|....*....|
gi 442627992  109 EWIVKLRDEVLKKELLDFWrDVLVKKQLGP 138
Cdd:pfam08785  68 DFLRDLKKKLLEGDRREFW-ELVRKNKLGL 96
Ku_PK_bind pfam08785
Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by ...
 217-323 1.28e-03

Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired. Ku is a component of a multi-protein complex that is involved in the NHEJ. Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). This domain is found at the C terminal of Ku which binds to DNA-PKcs.


Pssm-ID: 462604  Cd Length: 117  Bit Score: 38.34  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627992  217 NPLEEYRTLMKRfvltkiivPDSVHQasVKKIAAAAREIIWKLLFDgtpSAEDQN--KAAELLQEYKGDA-GFYGPDDYN 293
Cdd:pfam08785   1 NPVPDFKQLLAR--------GDDVDA--VEKAVKQMGNIIEDLVRD---SFGDSNydKALECLRALREECiEEEEPDLYN 67

                          90       100       110
                  ....*....|....*....|....*....|
gi 442627992  294 SWIFNLRDEVLTKELLDFWrDKMVKMELGP 323
Cdd:pfam08785  68 DFLRDLKKKLLEGDRREFW-ELVRKNKLGL 96
 
Name Accession Description Interval E-value
Ku_PK_bind pfam08785
Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by ...
 31-138 2.12e-07

Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired. Ku is a component of a multi-protein complex that is involved in the NHEJ. Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). This domain is found at the C terminal of Ku which binds to DNA-PKcs.


Pssm-ID: 462604  Cd Length: 117  Bit Score: 49.12  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627992   31 DPVKDYQKLIETRVQVDEIvdDDVTKEnfdrtaaaARDVIWRLLFDeaGTSQSNTEKASQLLEEYRgDAC--FYDPTPYN 108
Cdd:pfam08785   1 NPVPDFKQLLARGDDVDAV--EKAVKQ--------MGNIIEDLVRD--SFGDSNYDKALECLRALR-EECieEEEPDLYN 67

                          90       100       110
                  ....*....|....*....|....*....|
gi 442627992  109 EWIVKLRDEVLKKELLDFWrDVLVKKQLGP 138
Cdd:pfam08785  68 DFLRDLKKKLLEGDRREFW-ELVRKNKLGL 96
Ku_PK_bind pfam08785
Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by ...
 217-323 1.28e-03

Ku C terminal domain like; The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired. Ku is a component of a multi-protein complex that is involved in the NHEJ. Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). This domain is found at the C terminal of Ku which binds to DNA-PKcs.


Pssm-ID: 462604  Cd Length: 117  Bit Score: 38.34  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627992  217 NPLEEYRTLMKRfvltkiivPDSVHQasVKKIAAAAREIIWKLLFDgtpSAEDQN--KAAELLQEYKGDA-GFYGPDDYN 293
Cdd:pfam08785   1 NPVPDFKQLLAR--------GDDVDA--VEKAVKQMGNIIEDLVRD---SFGDSNydKALECLRALREECiEEEEPDLYN 67

                          90       100       110
                  ....*....|....*....|....*....|
gi 442627992  294 SWIFNLRDEVLTKELLDFWrDKMVKMELGP 323
Cdd:pfam08785  68 DFLRDLKKKLLEGDRREFW-ELVRKNKLGL 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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