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Conserved domains on  [gi|442622271|ref|NP_001260704|]
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uncharacterized protein Dmel_CG12547, isoform B [Drosophila melanogaster]

Protein Classification

NHL domain-containing thioredoxin family protein( domain architecture ID 10122410)

NHL domain-containing thioredoxin family protein may function as a thiol disulfide reductase that catalyzes the reduction of protein disulfide bonds using an active site dithiol, present in a CXXC motif

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 262-618 8.51e-151

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


:

Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 441.63  E-value: 8.51e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 262 IGGHQPGFVDGDLTVARFNNPQGIAFLNENVLIVADTKNHAIRQISLTNAMVETLAGTGIQGNDRIGGRLGPLQPLSSPW 341
Cdd:cd14951    1 IGSGERGLKDGSFAEASFNEPQGLALLPGNILYVADTENHALRKIDLETGTVTTLAGTGEQGRDGEGGGPGREQPLSSPW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 342 DVAIFrtrdmdmsfhlderniPEKTIILISMAGTHQIWGYFPEGIIwwkfrkfepccCVSLIGNGLEENRNNSYPQNAAF 421
Cdd:cd14951   81 DVAWG----------------PEDDILYIAMAGTHQIWAYDLDTGT-----------CRVFAGSGNEGNRNGPYPHEAWF 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 422 AQPSGLAIAGD-VLYIADSESSSIRKASMIDGKVMPVVGGDRNPLNLFAFGDIDGRLFSAKLQHPLGVTFNDTnNKLYVA 500
Cdd:cd14951  134 AQPSGLSLAGWgELFVADSESSAIRAVSLKDGGVKTLVGGTRVGTGLFDFGDRDGPGAEALLQHPLGVAALPD-GSVYVA 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 501 DTYNHKIKIIDIDSNDISTLQIKSQEN---TNLILNEPAGLCLDASGRnLLVADTNNHSIHTIDLVTLIAQPFGLDFRQI 577
Cdd:cd14951  213 DTYNHKIKRVDPATGEVSTLAGTGKAGykdLEAQFSEPSGLVVDGDGR-LYVADTNNHRIRRLDLPTEALEVLTLAHRTL 291

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 442622271 578 ASASEIDApqdtqKPTENNIVKALPLDLIKPSKIFFNLRLS 618
Cdd:cd14951  292 RPATPPAP-----GPLRLRVRFTAPAGQKLDDRWGPSTRLK 327
TlpA_like_DipZ_like cd03012
TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a ...
 58-184 8.30e-71

TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA family belong to this subfamily. TlpA is a disulfide reductase known to have a crucial role in the biogenesis of cytochrome aa3.


:

Pssm-ID: 239310 [Multi-domain]  Cd Length: 126  Bit Score: 226.42  E-value: 8.30e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  58 VEFESDLEWFNVSCPLSIKGLQGKVIILDFFTYCCINCMHVLQELHLLEERFPIeSGVVVIGVHSPKFENERNAANILSA 137
Cdd:cd03012    1 PEFEGILQWLNTDKPLSLAQLRGKVVLLDFWTYCCINCLHTLPYLTDLEQKYKD-DGLVVIGVHSPEFAFERDLANVKSA 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 442622271 138 VQRYGISHPIVNDSRSGMWRALGIRCWPSLLILSPTGVPMMLLMGEG 184
Cdd:cd03012   80 VLRYGITYPVANDNDYATWRAYGNQYWPALYLIDPTGNVRHVHFGEG 126
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 205-306 7.84e-11

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd05819:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 269  Bit Score: 63.49  E-value: 7.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 205 IIDHRGLPLKLFND-FQPASNLRFPAKIVQGPNGLYAIADTGNNRVLVLTAGGVVQHRIGghqpgfvDGDLTVARFNNPQ 283
Cdd:cd05819  174 VFDPDGNFLTTFGStGTGPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDPDGAGFGGNG-------NFLGSDGQFNRPS 246

                         90       100
                 ....*....|....*....|...
gi 442622271 284 GIAFLNENVLIVADTKNHAIRQI 306
Cdd:cd05819  247 GLAVDSDGNLYVADTGNNRIQVF 269
 
Name Accession Description Interval E-value
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 262-618 8.51e-151

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 441.63  E-value: 8.51e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 262 IGGHQPGFVDGDLTVARFNNPQGIAFLNENVLIVADTKNHAIRQISLTNAMVETLAGTGIQGNDRIGGRLGPLQPLSSPW 341
Cdd:cd14951    1 IGSGERGLKDGSFAEASFNEPQGLALLPGNILYVADTENHALRKIDLETGTVTTLAGTGEQGRDGEGGGPGREQPLSSPW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 342 DVAIFrtrdmdmsfhlderniPEKTIILISMAGTHQIWGYFPEGIIwwkfrkfepccCVSLIGNGLEENRNNSYPQNAAF 421
Cdd:cd14951   81 DVAWG----------------PEDDILYIAMAGTHQIWAYDLDTGT-----------CRVFAGSGNEGNRNGPYPHEAWF 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 422 AQPSGLAIAGD-VLYIADSESSSIRKASMIDGKVMPVVGGDRNPLNLFAFGDIDGRLFSAKLQHPLGVTFNDTnNKLYVA 500
Cdd:cd14951  134 AQPSGLSLAGWgELFVADSESSAIRAVSLKDGGVKTLVGGTRVGTGLFDFGDRDGPGAEALLQHPLGVAALPD-GSVYVA 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 501 DTYNHKIKIIDIDSNDISTLQIKSQEN---TNLILNEPAGLCLDASGRnLLVADTNNHSIHTIDLVTLIAQPFGLDFRQI 577
Cdd:cd14951  213 DTYNHKIKRVDPATGEVSTLAGTGKAGykdLEAQFSEPSGLVVDGDGR-LYVADTNNHRIRRLDLPTEALEVLTLAHRTL 291

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 442622271 578 ASASEIDApqdtqKPTENNIVKALPLDLIKPSKIFFNLRLS 618
Cdd:cd14951  292 RPATPPAP-----GPLRLRVRFTAPAGQKLDDRWGPSTRLK 327
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 16-649 1.23e-145

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 452.00  E-value: 1.23e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271   16 ITDELLQAYKSSKGENEKAGTIVKFLDrWNDDISIAKLKDLTVEFESDLEWFNVScPLSIKG-LQGKVIILDFFTYCCIN 94
Cdd:PLN02919  357 LWNALFGVDDPSFAQNSGEGCVQQFVS-YISDLESKKTATKVPEFPPKLDWLNTA-PLQFRRdLKGKVVILDFWTYCCIN 434

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271   95 CMHVLQELHLLEERFPiESGVVVIGVHSPKFENERNAANILSAVQRYGISHPIVNDSRSGMWRALGIRCWPSLLILSPTG 174
Cdd:PLN02919  435 CMHVLPDLEFLEKKYK-DQPFTVVGVHSAKFDNEKDLEAIRNAVLRYNISHPVVNDGDMYLWRELGVSSWPTFAVVSPNG 513

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  175 VPMMLLMGEGHGKFLQDFFSSALSYFSRQGIIDHRGLPLKLFNDFQP---ASNLRFPAKI-VQGPNGLYAIADTGNNRVL 250
Cdd:PLN02919  514 KLIAQLSGEGHRKDLDDLVEAALQYYGEKKLLDSTPLPLSLEKDNDPrllTSPLKFPGKLaIDLLNNRLFISDSNHNRIV 593

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  251 VLTAGGVVQHRIGGH-QPGFVDGDLTVARFNNPQGIAF-LNENVLIVADTKNHAIRQISLTNAMVETLAGTGIQGNDRIG 328
Cdd:PLN02919  594 VTDLDGNFIVQIGSTgEEGLRDGSFEDATFNRPQGLAYnAKKNLLYVADTENHALREIDFVNETVRTLAGNGTKGSDYQG 673

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  329 GRLGPLQPLSSPWDVAifrtrdmdmsFHlderniPEKTIILISMAGTHQIWGY-FPEGIIwwkfRKFEpcccvsliGNGL 407
Cdd:PLN02919  674 GKKGTSQVLNSPWDVC----------FE------PVNEKVYIAMAGQHQIWEYnISDGVT----RVFS--------GDGY 725

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  408 EENRNNSYPQNAAFAQPSGLAIAGDV--LYIADSESSSIRKASMIDGKVMPVVGGDRN-PLNLFAFGDIDGRLFSAKLQH 484
Cdd:PLN02919  726 ERNLNGSSGTSTSFAQPSGISLSPDLkeLYIADSESSSIRALDLKTGGSRLLAGGDPTfSDNLFKFGDHDGVGSEVLLQH 805

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  485 PLGVTFNdTNNKLYVADTYNHKIKIIDIDSNDISTLQ------IKSQENTNLILNEPAGLCLDASGRnLLVADTNNHSIH 558
Cdd:PLN02919  806 PLGVLCA-KDGQIYVADSYNHKIKKLDPATKRVTTLAgtgkagFKDGKALKAQLSEPAGLALGENGR-LFVADTNNSLIR 883

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  559 TIDL--------VTL--------IAQPFGLD-FRQIASAseidapqDTQkptennIVKalpLDLIKPSKIFFNLRLS--P 619
Cdd:PLN02919  884 YLDLnkgeaaeiLTLelkgvqppRPKSKSLKrLRRRSSA-------DTQ------VIK---VDGVTSLEGDLQLKISlpP 947

                         650       660       670
                  ....*....|....*....|....*....|.
gi 442622271  620 RFNFTKEAPQKWIVKTVCQ-SVIVNPTCGNL 649
Cdd:PLN02919  948 GYHFSKEARSKFEVEVEPEnAVDIDPDEGTL 978
TlpA_like_DipZ_like cd03012
TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a ...
 58-184 8.30e-71

TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA family belong to this subfamily. TlpA is a disulfide reductase known to have a crucial role in the biogenesis of cytochrome aa3.


Pssm-ID: 239310 [Multi-domain]  Cd Length: 126  Bit Score: 226.42  E-value: 8.30e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  58 VEFESDLEWFNVSCPLSIKGLQGKVIILDFFTYCCINCMHVLQELHLLEERFPIeSGVVVIGVHSPKFENERNAANILSA 137
Cdd:cd03012    1 PEFEGILQWLNTDKPLSLAQLRGKVVLLDFWTYCCINCLHTLPYLTDLEQKYKD-DGLVVIGVHSPEFAFERDLANVKSA 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 442622271 138 VQRYGISHPIVNDSRSGMWRALGIRCWPSLLILSPTGVPMMLLMGEG 184
Cdd:cd03012   80 VLRYGITYPVANDNDYATWRAYGNQYWPALYLIDPTGNVRHVHFGEG 126
TrxA COG0526
Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, ...
 72-198 1.99e-21

Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440292 [Multi-domain]  Cd Length: 139  Bit Score: 90.90  E-value: 1.99e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  72 PLSIKGLQGKVIILDFFTYCCINCMHVLQELHLLEERFPiesGVVVIGVHSpkfenERNAANILSAVQRYGISHPIVNDS 151
Cdd:COG0526   20 PLSLADLKGKPVLVNFWATWCPPCRAEMPVLKELAEEYG---GVVFVGVDV-----DENPEAVKAFLKELGLPYPVLLDP 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 442622271 152 RSGMWRALGIRCWPSLLILSPTGVPMMLLMGEGHGKFLQDFFSSALS 198
Cdd:COG0526   92 DGELAKAYGVRGIPTTVLIDKDGKIVARHVGPLSPEELEEALEKLLA 138
Thioredoxin_8 pfam13905
Thioredoxin-like; Thioredoxins are small enzymes that participate in redox reactions, via the ...
 80-174 1.35e-15

Thioredoxin-like; Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.


Pssm-ID: 464033 [Multi-domain]  Cd Length: 95  Bit Score: 72.73  E-value: 1.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271   80 GKVIILDFFTYCCINCMHVLQELHLLEERFPIESGVVVIGVHSPKFENERNaaNILSAVQRYGISHPIVNDSRSGMWRAL 159
Cdd:pfam13905   1 GKVVLLYFGASWCKPCRRFTPLLKELYEKLKKKKNVEIVFVSLDRDLEEFK--DYLKKMPKDWLSVPFDDDERNELKRKY 78

                          90
                  ....*....|....*
gi 442622271  160 GIRCWPSLLILSPTG 174
Cdd:pfam13905  79 GVNAIPTLVLLDPNG 93
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
227-567 3.90e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 67.35  E-value: 3.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 227 FPAKIVQGPNGLYAIADTGNNRVLVL--TAGGVVQHRIGGhqpgfvdgdltvarFNNPQGIAFLNENVLIVADTKNHAIR 304
Cdd:COG4257   18 GPRDVAVDPDGAVWFTDQGGGRIGRLdpATGEFTEYPLGG--------------GSGPHGIAVDPDGNLWFTDNGNNRIG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 305 QISLTNAMVETLAGTGiqgndriggrlgplqPLSSPWDVAifrtrdmdmsFHLDERnipektiILISMAGTHQIwgyfpe 384
Cdd:COG4257   84 RIDPKTGEITTFALPG---------------GGSNPHGIA----------FDPDGN-------LWFTDQGGNRI------ 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 385 giiwwkfRKFEPCccvsliGNGLEEnrnnsYPQNAAFAQPSGLAIAGD-VLYIADSESSSIRKasmIDgkvmpvvggdrn 463
Cdd:COG4257  126 -------GRLDPA------TGEVTE-----FPLPTGGAGPYGIAVDPDgNLWVTDFGANAIGR---ID------------ 172

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 464 plnlFAFGDIDGRLFSAKLQHPLGVTFnDTNNKLYVADTYNHKIKIIDIDSNDISTLQIKSQEntnlilNEPAGLCLDAS 543
Cdd:COG4257  173 ----PDTGTLTEYALPTPGAGPRGLAV-DPDGNLWVADTGSGRIGRFDPKTGTVTEYPLPGGG------ARPYGVAVDGD 241

                        330       340
                 ....*....|....*....|....
gi 442622271 544 GRnLLVADTNNHSIHTIDLVTLIA 567
Cdd:COG4257  242 GR-VWFAESGANRIVRFDPDTELT 264
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 205-306 7.84e-11

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 63.49  E-value: 7.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 205 IIDHRGLPLKLFND-FQPASNLRFPAKIVQGPNGLYAIADTGNNRVLVLTAGGVVQHRIGghqpgfvDGDLTVARFNNPQ 283
Cdd:cd05819  174 VFDPDGNFLTTFGStGTGPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDPDGAGFGGNG-------NFLGSDGQFNRPS 246

                         90       100
                 ....*....|....*....|...
gi 442622271 284 GIAFLNENVLIVADTKNHAIRQI 306
Cdd:cd05819  247 GLAVDSDGNLYVADTGNNRIQVF 269
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 279-305 4.10e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 35.07  E-value: 4.10e-03
                          10        20
                  ....*....|....*....|....*..
gi 442622271  279 FNNPQGIAFLNENVLIVADTKNHAIRQ 305
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQV 27
 
Name Accession Description Interval E-value
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 262-618 8.51e-151

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 441.63  E-value: 8.51e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 262 IGGHQPGFVDGDLTVARFNNPQGIAFLNENVLIVADTKNHAIRQISLTNAMVETLAGTGIQGNDRIGGRLGPLQPLSSPW 341
Cdd:cd14951    1 IGSGERGLKDGSFAEASFNEPQGLALLPGNILYVADTENHALRKIDLETGTVTTLAGTGEQGRDGEGGGPGREQPLSSPW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 342 DVAIFrtrdmdmsfhlderniPEKTIILISMAGTHQIWGYFPEGIIwwkfrkfepccCVSLIGNGLEENRNNSYPQNAAF 421
Cdd:cd14951   81 DVAWG----------------PEDDILYIAMAGTHQIWAYDLDTGT-----------CRVFAGSGNEGNRNGPYPHEAWF 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 422 AQPSGLAIAGD-VLYIADSESSSIRKASMIDGKVMPVVGGDRNPLNLFAFGDIDGRLFSAKLQHPLGVTFNDTnNKLYVA 500
Cdd:cd14951  134 AQPSGLSLAGWgELFVADSESSAIRAVSLKDGGVKTLVGGTRVGTGLFDFGDRDGPGAEALLQHPLGVAALPD-GSVYVA 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 501 DTYNHKIKIIDIDSNDISTLQIKSQEN---TNLILNEPAGLCLDASGRnLLVADTNNHSIHTIDLVTLIAQPFGLDFRQI 577
Cdd:cd14951  213 DTYNHKIKRVDPATGEVSTLAGTGKAGykdLEAQFSEPSGLVVDGDGR-LYVADTNNHRIRRLDLPTEALEVLTLAHRTL 291

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 442622271 578 ASASEIDApqdtqKPTENNIVKALPLDLIKPSKIFFNLRLS 618
Cdd:cd14951  292 RPATPPAP-----GPLRLRVRFTAPAGQKLDDRWGPSTRLK 327
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 16-649 1.23e-145

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 452.00  E-value: 1.23e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271   16 ITDELLQAYKSSKGENEKAGTIVKFLDrWNDDISIAKLKDLTVEFESDLEWFNVScPLSIKG-LQGKVIILDFFTYCCIN 94
Cdd:PLN02919  357 LWNALFGVDDPSFAQNSGEGCVQQFVS-YISDLESKKTATKVPEFPPKLDWLNTA-PLQFRRdLKGKVVILDFWTYCCIN 434

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271   95 CMHVLQELHLLEERFPiESGVVVIGVHSPKFENERNAANILSAVQRYGISHPIVNDSRSGMWRALGIRCWPSLLILSPTG 174
Cdd:PLN02919  435 CMHVLPDLEFLEKKYK-DQPFTVVGVHSAKFDNEKDLEAIRNAVLRYNISHPVVNDGDMYLWRELGVSSWPTFAVVSPNG 513

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  175 VPMMLLMGEGHGKFLQDFFSSALSYFSRQGIIDHRGLPLKLFNDFQP---ASNLRFPAKI-VQGPNGLYAIADTGNNRVL 250
Cdd:PLN02919  514 KLIAQLSGEGHRKDLDDLVEAALQYYGEKKLLDSTPLPLSLEKDNDPrllTSPLKFPGKLaIDLLNNRLFISDSNHNRIV 593

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  251 VLTAGGVVQHRIGGH-QPGFVDGDLTVARFNNPQGIAF-LNENVLIVADTKNHAIRQISLTNAMVETLAGTGIQGNDRIG 328
Cdd:PLN02919  594 VTDLDGNFIVQIGSTgEEGLRDGSFEDATFNRPQGLAYnAKKNLLYVADTENHALREIDFVNETVRTLAGNGTKGSDYQG 673

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  329 GRLGPLQPLSSPWDVAifrtrdmdmsFHlderniPEKTIILISMAGTHQIWGY-FPEGIIwwkfRKFEpcccvsliGNGL 407
Cdd:PLN02919  674 GKKGTSQVLNSPWDVC----------FE------PVNEKVYIAMAGQHQIWEYnISDGVT----RVFS--------GDGY 725

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  408 EENRNNSYPQNAAFAQPSGLAIAGDV--LYIADSESSSIRKASMIDGKVMPVVGGDRN-PLNLFAFGDIDGRLFSAKLQH 484
Cdd:PLN02919  726 ERNLNGSSGTSTSFAQPSGISLSPDLkeLYIADSESSSIRALDLKTGGSRLLAGGDPTfSDNLFKFGDHDGVGSEVLLQH 805

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  485 PLGVTFNdTNNKLYVADTYNHKIKIIDIDSNDISTLQ------IKSQENTNLILNEPAGLCLDASGRnLLVADTNNHSIH 558
Cdd:PLN02919  806 PLGVLCA-KDGQIYVADSYNHKIKKLDPATKRVTTLAgtgkagFKDGKALKAQLSEPAGLALGENGR-LFVADTNNSLIR 883

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  559 TIDL--------VTL--------IAQPFGLD-FRQIASAseidapqDTQkptennIVKalpLDLIKPSKIFFNLRLS--P 619
Cdd:PLN02919  884 YLDLnkgeaaeiLTLelkgvqppRPKSKSLKrLRRRSSA-------DTQ------VIK---VDGVTSLEGDLQLKISlpP 947

                         650       660       670
                  ....*....|....*....|....*....|.
gi 442622271  620 RFNFTKEAPQKWIVKTVCQ-SVIVNPTCGNL 649
Cdd:PLN02919  948 GYHFSKEARSKFEVEVEPEnAVDIDPDEGTL 978
TlpA_like_DipZ_like cd03012
TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a ...
 58-184 8.30e-71

TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA family belong to this subfamily. TlpA is a disulfide reductase known to have a crucial role in the biogenesis of cytochrome aa3.


Pssm-ID: 239310 [Multi-domain]  Cd Length: 126  Bit Score: 226.42  E-value: 8.30e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  58 VEFESDLEWFNVSCPLSIKGLQGKVIILDFFTYCCINCMHVLQELHLLEERFPIeSGVVVIGVHSPKFENERNAANILSA 137
Cdd:cd03012    1 PEFEGILQWLNTDKPLSLAQLRGKVVLLDFWTYCCINCLHTLPYLTDLEQKYKD-DGLVVIGVHSPEFAFERDLANVKSA 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 442622271 138 VQRYGISHPIVNDSRSGMWRALGIRCWPSLLILSPTGVPMMLLMGEG 184
Cdd:cd03012   80 VLRYGITYPVANDNDYATWRAYGNQYWPALYLIDPTGNVRHVHFGEG 126
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 222-560 5.63e-48

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 171.94  E-value: 5.63e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 222 ASNLRFPAKIVQGPNG-LYaIADTGNNRVLVLTAGGVVQHRIGGHQPGFVDGDLTVARFNNPQGIAFLNENVLIVADTKN 300
Cdd:cd14953   19 AARFNSPSGVAVDAAGnLY-VADRGNHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNTPSGVAVDAAGNLYVADTGN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 301 HAIRQISlTNAMVETLAGTGIQGNDriGGRLGPLQPLSSPWDVAIfrtrdmDMSFHLdernipektiiLISMAGTHQIwg 380
Cdd:cd14953   98 HRIRKIT-PDGVVSTLAGTGTAGFS--DDGGATAAQFNYPTGVAV------DAAGNL-----------YVADTGNHRI-- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 381 yfpegiiwwkfRKFEPCCCVS-LIGNGLEENRNNSYPQNAAFAQPSGLAIAGD-VLYIADSESSSIRKASMiDGKVMPVV 458
Cdd:cd14953  156 -----------RKITPDGVVTtVAGTGGAGYAGDGPATAAQFNNPTGVAVDAAgNLYVADRGNHRIRKITP-DGVVTTVA 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 459 GgdrnplNLFAFGDIDGRLFSAKLQHPLGVTFNDTNNkLYVADTYNHKIKIIDIDSNdISTLQIKSQEN-------TNLI 531
Cdd:cd14953  224 G------TGTAGFSGDGGATAAQLNNPTGVAVDAAGN-LYVADSGNHRIRKITPAGV-VTTVAGGGAGFsgdggpaTSAQ 295

                        330       340
                 ....*....|....*....|....*....
gi 442622271 532 LNEPAGLCLDASGrNLLVADTNNHSIHTI 560
Cdd:cd14953  296 FNNPTGVAVDAAG-NLYVADTGNNRIRKI 323
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 267-561 6.71e-39

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 146.52  E-value: 6.71e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 267 PGFVDGDLTVARFNNPQGIAFLNENVLIVADTKNHAIRQISlTNAMVETLAGTGIQGNDriGGrLGPLQPLSSPWDVAIf 346
Cdd:cd14953   10 AGFSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKIT-PDGVVTTVAGTGTAGFA--DG-GGAAAQFNTPSGVAV- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 347 rtrdmDmsfhlDERNIpektiiLISMAGTHQIwgyfpegiiwwkfRKFEPCCCVS-LIGNGLEENRNNSYPQNAAFAQPS 425
Cdd:cd14953   85 -----D-----AAGNL------YVADTGNHRI-------------RKITPDGVVStLAGTGTAGFSDDGGATAAQFNYPT 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 426 GLAI-AGDVLYIADSESSSIRKASMiDGKVMPVVGGDRnplnlfAFGDIDGRLFSAKLQHPLGVTFNDTNNkLYVADTYN 504
Cdd:cd14953  136 GVAVdAAGNLYVADTGNHRIRKITP-DGVVTTVAGTGG------AGYAGDGPATAAQFNNPTGVAVDAAGN-LYVADRGN 207

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442622271 505 HKIKIIDIDsNDISTL-------QIKSQENTNLILNEPAGLCLDASGrNLLVADTNNHSIHTID 561
Cdd:cd14953  208 HRIRKITPD-GVVTTVagtgtagFSGDGGATAAQLNNPTGVAVDAAG-NLYVADSGNHRIRKIT 269
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 217-507 2.37e-35

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 136.51  E-value: 2.37e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 217 NDFQPASNLRFPAKIVQGPNG-LYaIADTGNNRVLVLTAGGVVQHRIGGHQPGFV-DGDLTVARFNNPQGIAFLNENVLI 294
Cdd:cd14953   68 DGGGAAAQFNTPSGVAVDAAGnLY-VADTGNHRIRKITPDGVVSTLAGTGTAGFSdDGGATAAQFNYPTGVAVDAAGNLY 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 295 VADTKNHAIRQISlTNAMVETLAGTGIQGNDRIGGRLGPLqpLSSPWDVAIFRtrdmdmsfhldernipeKTIILISMAG 374
Cdd:cd14953  147 VADTGNHRIRKIT-PDGVVTTVAGTGGAGYAGDGPATAAQ--FNNPTGVAVDA-----------------AGNLYVADRG 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 375 THQIWGYFPEGIIwwkfrkfepcccVSLIGNGLEENRNNSYPQNAAFAQPSGLAI-AGDVLYIADSESSSIRKASmIDGK 453
Cdd:cd14953  207 NHRIRKITPDGVV------------TTVAGTGTAGFSGDGGATAAQLNNPTGVAVdAAGNLYVADSGNHRIRKIT-PAGV 273

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442622271 454 VMPVVGGdrnPLNLFAFGDIDGrlfSAKLQHPLGVTFNDTNNkLYVADTYNHKI 507
Cdd:cd14953  274 VTTVAGG---GAGFSGDGGPAT---SAQFNNPTGVAVDAAGN-LYVADTGNNRI 320
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 225-560 3.72e-33

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 128.59  E-value: 3.72e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 225 LRFPAKIVQGPNGLYAIADTGNNRVLVLTAGGVVQHRIGGhqPGFVDGdltvaRFNNPQGIAFLNENVLIVADTKNHAIR 304
Cdd:cd05819    7 LNNPQGIAVDSSGNIYVADTGNNRIQVFDPDGNFITSFGS--FGSGDG-----QFNEPAGVAVDSDGNLYVADTGNHRIQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 305 QISLTNAMVETLAGTGIQGNDriggrlgplqpLSSPWDVAIfrtrdmdmsfhlDERNIpektiILISMAGTHQIWGYFPE 384
Cdd:cd05819   80 KFDPDGNFLASFGGSGDGDGE-----------FNGPRGIAV------------DSSGN-----IYVADTGNHRIQKFDPD 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 385 GIiwwkfrkfepccCVSLIGNGLEENrnnsypqnAAFAQPSGLAIAGDV-LYIADSESSSIRKASmIDGKVMPVVGGdrn 463
Cdd:cd05819  132 GE------------FLTTFGSGGSGP--------GQFNGPTGVAVDSDGnIYVADTGNHRIQVFD-PDGNFLTTFGS--- 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 464 plnlfaFGDIDGRLfsaklQHPLGVTFnDTNNKLYVADTYNHKIKIIDIDSNDISTLQikSQENTNLILNEPAGLCLDAS 543
Cdd:cd05819  188 ------TGTGPGQF-----NYPTGIAV-DSDGNIYVADSGNNRVQVFDPDGAGFGGNG--NFLGSDGQFNRPSGLAVDSD 253

                        330
                 ....*....|....*..
gi 442622271 544 GrNLLVADTNNHSIHTI 560
Cdd:cd05819  254 G-NLYVADTGNNRIQVF 269
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 279-571 9.32e-30

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 118.96  E-value: 9.32e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 279 FNNPQGIAFLNENVLIVADTKNHAIRQISLTNamvETLAGTGIQGNDriggrlgpLQPLSSPWDVAIfrtrdmdmsfhlD 358
Cdd:cd05819    7 LNNPQGIAVDSSGNIYVADTGNNRIQVFDPDG---NFITSFGSFGSG--------DGQFNEPAGVAV------------D 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 359 ERNIpektiILISMAGTHQIWGYFPEGIIWWKFRKFepcccvsliGNGLEEnrnnsypqnaaFAQPSGLAIAGD-VLYIA 437
Cdd:cd05819   64 SDGN-----LYVADTGNHRIQKFDPDGNFLASFGGS---------GDGDGE-----------FNGPRGIAVDSSgNIYVA 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 438 DSESSSIRKASmIDGKVMPVVGGdrnplnlfaFGDIDGrlfsaKLQHPLGVTFNDTNNkLYVADTYNHKIKIIDIDSNDI 517
Cdd:cd05819  119 DTGNHRIQKFD-PDGEFLTTFGS---------GGSGPG-----QFNGPTGVAVDSDGN-IYVADTGNHRIQVFDPDGNFL 182

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442622271 518 STlqIKSQENTNLILNEPAGLCLDASGrNLLVADTNNHSIHTIDLVTLIAQPFG 571
Cdd:cd05819  183 TT--FGSTGTGPGQFNYPTGIAVDSDG-NIYVADSGNNRVQVFDPDGAGFGGNG 233
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 224-510 3.79e-25

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 105.48  E-value: 3.79e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 224 NLRFPAKIVQGPNGLYAIADTGNNRVLVLTAGGVVQHRIGGhqPGFVDGDltvarFNNPQGIAFLNENVLIVADTKNHAI 303
Cdd:cd05819   53 QFNEPAGVAVDSDGNLYVADTGNHRIQKFDPDGNFLASFGG--SGDGDGE-----FNGPRGIAVDSSGNIYVADTGNHRI 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 304 RQISLTNAMVETlagtgiqgndrIGGRLGPLQPLSSPWDVAIFRTRDmdmsfhldernipektiILISMAGTHQIWGYFP 383
Cdd:cd05819  126 QKFDPDGEFLTT-----------FGSGGSGPGQFNGPTGVAVDSDGN-----------------IYVADTGNHRIQVFDP 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 384 EGIIWWKFrkfepcccvsligngleenrNNSYPQNAAFAQPSGLAIAGD-VLYIADSESSSIRKASmIDGKVMPVVGGDR 462
Cdd:cd05819  178 DGNFLTTF--------------------GSTGTGPGQFNYPTGIAVDSDgNIYVADSGNNRVQVFD-PDGAGFGGNGNFL 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 442622271 463 NPLNLFAFgdidgrlfsaklqhPLGVTFnDTNNKLYVADTYNHKIKII 510
Cdd:cd05819  237 GSDGQFNR--------------PSGLAV-DSDGNLYVADTGNNRIQVF 269
TlpA_like_family cd02966
TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are ...
 72-182 8.01e-23

TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.


Pssm-ID: 239264 [Multi-domain]  Cd Length: 116  Bit Score: 93.84  E-value: 8.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  72 PLSIKGLQGKVIILDFFTYCCINCMHVLQELHLLEERFPiESGVVVIGVHSPkfenERNAANILSAVQRYGISHPIVNDS 151
Cdd:cd02966   11 PVSLSDLKGKVVLVNFWASWCPPCRAEMPELEALAKEYK-DDGVEVVGVNVD----DDDPAAVKAFLKKYGITFPVLLDP 85

                         90       100       110
                 ....*....|....*....|....*....|.
gi 442622271 152 RSGMWRALGIRCWPSLLILSPTGVPMMLLMG 182
Cdd:cd02966   86 DGELAKAYGVRGLPTTFLIDRDGRIRARHVG 116
TrxA COG0526
Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, ...
 72-198 1.99e-21

Thiol-disulfide isomerase or thioredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440292 [Multi-domain]  Cd Length: 139  Bit Score: 90.90  E-value: 1.99e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  72 PLSIKGLQGKVIILDFFTYCCINCMHVLQELHLLEERFPiesGVVVIGVHSpkfenERNAANILSAVQRYGISHPIVNDS 151
Cdd:COG0526   20 PLSLADLKGKPVLVNFWATWCPPCRAEMPVLKELAEEYG---GVVFVGVDV-----DENPEAVKAFLKELGLPYPVLLDP 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 442622271 152 RSGMWRALGIRCWPSLLILSPTGVPMMLLMGEGHGKFLQDFFSSALS 198
Cdd:COG0526   92 DGELAKAYGVRGIPTTVLIDKDGKIVARHVGPLSPEELEEALEKLLA 138
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 418-567 3.37e-18

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 86.43  E-value: 3.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 418 NAAFAQPSGLAI-AGDVLYIADSESSSIRKASmIDGKVMpVVGGDRNPlnlfafGDIDGRLFSAKLQHPLGVTFNDTNNk 496
Cdd:cd14953   19 AARFNSPSGVAVdAAGNLYVADRGNHRIRKIT-PDGVVT-TVAGTGTA------GFADGGGAAAQFNTPSGVAVDAAGN- 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 497 LYVADTYNHKIKIIDIDSNdISTL-----QIKSQEN--TNLILNEPAGLCLDASGrNLLVADTNNHSIHTID---LVTLI 566
Cdd:cd14953   90 LYVADTGNHRIRKITPDGV-VSTLagtgtAGFSDDGgaTAAQFNYPTGVAVDAAG-NLYVADTGNHRIRKITpdgVVTTV 167


                 .
gi 442622271 567 A 567
Cdd:cd14953  168 A 168
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 216-345 4.67e-17

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 82.96  E-value: 4.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 216 FNDFQPASN--LRFPAKIVQGPNG-LYaIADTGNNRVLVLTAGGVVQHRIGGHQPGFV-DGDLTVARFNNPQGIAFLNEN 291
Cdd:cd14953  175 YAGDGPATAaqFNNPTGVAVDAAGnLY-VADRGNHRIRKITPDGVVTTVAGTGTAGFSgDGGATAAQLNNPTGVAVDAAG 253

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442622271 292 VLIVADTKNHAIRQISlTNAMVETLAG--TGIQGNDRIGgrlGPLQpLSSPWDVAI 345
Cdd:cd14953  254 NLYVADSGNHRIRKIT-PAGVVTTVAGggAGFSGDGGPA---TSAQ-FNNPTGVAV 304
Thioredoxin_8 pfam13905
Thioredoxin-like; Thioredoxins are small enzymes that participate in redox reactions, via the ...
 80-174 1.35e-15

Thioredoxin-like; Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.


Pssm-ID: 464033 [Multi-domain]  Cd Length: 95  Bit Score: 72.73  E-value: 1.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271   80 GKVIILDFFTYCCINCMHVLQELHLLEERFPIESGVVVIGVHSPKFENERNaaNILSAVQRYGISHPIVNDSRSGMWRAL 159
Cdd:pfam13905   1 GKVVLLYFGASWCKPCRRFTPLLKELYEKLKKKKNVEIVFVSLDRDLEEFK--DYLKKMPKDWLSVPFDDDERNELKRKY 78

                          90
                  ....*....|....*
gi 442622271  160 GIRCWPSLLILSPTG 174
Cdd:pfam13905  79 GVNAIPTLVLLDPNG 93
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 220-446 7.49e-15

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 75.43  E-value: 7.49e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 220 QPASNLRFPAKIVQGPNGLYAIADTGNNRVLVLTAGGVVQHRIGGhqPGFVDGDltvarFNNPQGIAFLNENVLIVADTK 299
Cdd:cd05819   96 DGDGEFNGPRGIAVDSSGNIYVADTGNHRIQKFDPDGEFLTTFGS--GGSGPGQ-----FNGPTGVAVDSDGNIYVADTG 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 300 NHAIRQISLTNamvETLAGTGIQGNdriggrlGPLQpLSSPWDVAIFRTRDmdmsfhldernipektiILISMAGTHQIW 379
Cdd:cd05819  169 NHRIQVFDPDG---NFLTTFGSTGT-------GPGQ-FNYPTGIAVDSDGN-----------------IYVADSGNNRVQ 220

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442622271 380 GYFPEGIIWwkfrkfepcccvslIGNGleenrnNSYPQNAAFAQPSGLAIAGD-VLYIADSESSSIRK 446
Cdd:cd05819  221 VFDPDGAGF--------------GGNG------NFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQV 268
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 469-567 2.69e-14

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 74.49  E-value: 2.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 469 AFGDIDGRLFSAKLQHPLGVTFnDTNNKLYVADTYNHKIKIIDIDSNdISTLQIKSQE------NTNLILNEPAGLCLDA 542
Cdd:cd14953    9 TAGFSGGGGTAARFNSPSGVAV-DAAGNLYVADRGNHRIRKITPDGV-VTTVAGTGTAgfadggGAAAQFNTPSGVAVDA 86

                         90       100
                 ....*....|....*....|....*...
gi 442622271 543 SGrNLLVADTNNHSIHTIDL---VTLIA 567
Cdd:cd14953   87 AG-NLYVADTGNHRIRKITPdgvVSTLA 113
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 400-562 7.57e-14

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 72.23  E-value: 7.57e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 400 VSLIGNGLEENrnnsypqnaaFAQPSGLAI-AGDVLYIADSESssirkasmidGKVMpVVGGDRNPLNLFAFGDIDGRlf 478
Cdd:cd14962   45 VFVIGNAGPNR----------FVSPIGVAIdANGNLYVSDAEL----------GKVF-VFDRDGKFLRAIGAGALFKR-- 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 479 saklqhPLGVTFNDTNNKLYVADTYNHKIKIIDIDSN---DISTLQIKSQEntnliLNEPAGLCLDASGrNLLVADTNNH 555
Cdd:cd14962  102 ------PTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRllfDIGKRGSGPGE-----FNLPTDLAVDRDG-NLYVTDTMNF 169


                 ....*..
gi 442622271 556 SIHTIDL 562
Cdd:cd14962  170 RVQIFDA 176
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
227-567 3.90e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 67.35  E-value: 3.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 227 FPAKIVQGPNGLYAIADTGNNRVLVL--TAGGVVQHRIGGhqpgfvdgdltvarFNNPQGIAFLNENVLIVADTKNHAIR 304
Cdd:COG4257   18 GPRDVAVDPDGAVWFTDQGGGRIGRLdpATGEFTEYPLGG--------------GSGPHGIAVDPDGNLWFTDNGNNRIG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 305 QISLTNAMVETLAGTGiqgndriggrlgplqPLSSPWDVAifrtrdmdmsFHLDERnipektiILISMAGTHQIwgyfpe 384
Cdd:COG4257   84 RIDPKTGEITTFALPG---------------GGSNPHGIA----------FDPDGN-------LWFTDQGGNRI------ 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 385 giiwwkfRKFEPCccvsliGNGLEEnrnnsYPQNAAFAQPSGLAIAGD-VLYIADSESSSIRKasmIDgkvmpvvggdrn 463
Cdd:COG4257  126 -------GRLDPA------TGEVTE-----FPLPTGGAGPYGIAVDPDgNLWVTDFGANAIGR---ID------------ 172

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 464 plnlFAFGDIDGRLFSAKLQHPLGVTFnDTNNKLYVADTYNHKIKIIDIDSNDISTLQIKSQEntnlilNEPAGLCLDAS 543
Cdd:COG4257  173 ----PDTGTLTEYALPTPGAGPRGLAV-DPDGNLWVADTGSGRIGRFDPKTGTVTEYPLPGGG------ARPYGVAVDGD 241

                        330       340
                 ....*....|....*....|....
gi 442622271 544 GRnLLVADTNNHSIHTIDLVTLIA 567
Cdd:COG4257  242 GR-VWFAESGANRIVRFDPDTELT 264
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 227-557 5.19e-12

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 66.91  E-value: 5.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 227 FPAKIVQGPNGLYAIADTGNNRVLVLTAGGVVQHRIGghqpgfvDGDLTVARFNNPQGIAFLNENVLIVADTKNHAIRQI 306
Cdd:cd14957   19 TPRGIAVDSAGNIYVADTGNNRIQVFTSSGVYSYSIG-------SGGTGSGQFNSPYGIAVDSNGNIYVADTDNNRIQVF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 307 SLTNAMVETLAGTGIQGNdriggrlgplqPLSSPWDVAIfrtrDMDMSfhldernipektiILISMAGTHQIWGYFPEGI 386
Cdd:cd14957   92 NSSGVYQYSIGTGGSGDG-----------QFNGPYGIAV----DSNGN-------------IYVADTGNHRIQVFTSSGT 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 387 IWWKfrkfepcccvslIGNGLEENrnnsypqnAAFAQPSGLAI--AGDVlYIADSESSSIRkasmidgkvmpVVGGDRNP 464
Cdd:cd14957  144 FSYS------------IGSGGTGP--------GQFNGPQGIAVdsDGNI-YVADTGNHRIQ-----------VFTSSGTF 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 465 LNLFAFGDIDGRLFSAklqhPLGVTFnDTNNKLYVADTYNHKIKIIDIDSNDISTlqIKSQENTNLILNEPAGLCLDASG 544
Cdd:cd14957  192 QYTFGSSGSGPGQFSD----PYGIAV-DSDGNIYVADTGNHRIQVFTSSGAYQYS--IGTSGSGNGQFNYPYGIAVDNDG 264

                        330
                 ....*....|...
gi 442622271 545 rNLLVADTNNHSI 557
Cdd:cd14957  265 -KIYVADSNNNRI 276
Bcp COG1225
Peroxiredoxin [Posttranslational modification, protein turnover, chaperones];
72-175 1.20e-11

Peroxiredoxin [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440838 [Multi-domain]  Cd Length: 136  Bit Score: 62.58  E-value: 1.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271  72 PLSIKGLQGKVIILDFFTYCCINCMHVLQELHLLEERFPiESGVVVIGVHSpkfeneRNAANILSAVQRYGISHPIVNDS 151
Cdd:COG1225   13 TVSLSDLRGKPVVLYFYATWCPGCTAELPELRDLYEEFK-DKGVEVLGVSS------DSDEAHKKFAEKYGLPFPLLSDP 85

                         90       100
                 ....*....|....*....|....
gi 442622271 152 RSGMWRALGIRCWPSLLILSPTGV 175
Cdd:COG1225   86 DGEVAKAYGVRGTPTTFLIDPDGK 109
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 237-559 1.94e-11

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 65.26  E-value: 1.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 237 GLYAIADTGNNRVLVLTAGGVVQHRIGGHqpGFVDGdltvaRFNNPQGIAFLNENVLIVADTKNHAIrqisltnaMVETL 316
Cdd:cd14954   35 GRIIVADRSNNRVQVFDPDGKFLRKFGSY--GSRDG-----QFDRPAGVAVNSRGRIIVADKDNHRI--------QVFDL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 317 AGTGIQGNDRIGGRLGPLQplsSPWDVAIfrtrdmdmsfhlDERNipektIILISMAGTHQIWGYFPEGiiwwKF-RKFe 395
Cdd:cd14954  100 NGRFLLKFGERGTKNGQFN---YPWGVAV------------DSEG-----RIYVSDTRNHRVQVFDSDG----QFiRKF- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 396 pcccvsligngleeNRNNSYPQNaaFAQPSGLAI-AGDVLYIADSESSSIRKASMiDGKVMPVVGGDrnplnlfafGDID 474
Cdd:cd14954  155 --------------GFEGAGPGQ--LDSPRGVAVnPDGNIVVSDFNNHRLQVFDP-DGQFLRFFGSE---------GSGN 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 475 GRlfsakLQHPLGVTFNDTNNkLYVADTYNHKIKIIDIDSNDISTlqIKSQENTNLILNEPAGLCLDASGRnLLVADTNN 554
Cdd:cd14954  209 GQ-----FKRPRGVAVDDEGN-IIVADSGNHRVQVFSPDGEFLCS--FGTEGNGEGQFDRPSGVAVTPDGR-IVVVDRGN 279


                 ....*
gi 442622271 555 HSIHT 559
Cdd:cd14954  280 HRIQV 284
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
426-574 2.34e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 64.33  E-value: 2.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 426 GLAIAGDVLYIADSESSSIRKASMIDGKVMPVVGGDRnplnlfafgdidgrlfsaklqHPLGVTFNDTNNKLYVADTYNH 505
Cdd:COG3391   74 DAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVGG---------------------GPRGLAVDPDGGRLYVADSGNG 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 506 KIKIIDIDSNDISTlQIKsqentnlILNEPAGLCLDASGRNLLVADTNNHSIHTI----DLVT--------LIAQPFGLD 573
Cdd:COG3391  133 RVSVIDTATGKVVA-TIP-------VGAGPHGIAVDPDGKRLYVANSGSNTVSVIvsviDTATgkvvatipVGGGPVGVA 204


                 .
gi 442622271 574 F 574
Cdd:COG3391  205 V 205
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 205-306 7.84e-11

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 63.49  E-value: 7.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 205 IIDHRGLPLKLFND-FQPASNLRFPAKIVQGPNGLYAIADTGNNRVLVLTAGGVVQHRIGghqpgfvDGDLTVARFNNPQ 283
Cdd:cd05819  174 VFDPDGNFLTTFGStGTGPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDPDGAGFGGNG-------NFLGSDGQFNRPS 246

                         90       100
                 ....*....|....*....|...
gi 442622271 284 GIAFLNENVLIVADTKNHAIRQI 306
Cdd:cd05819  247 GLAVDSDGNLYVADTGNNRIQVF 269
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 241-557 8.12e-11

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 63.36  E-value: 8.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 241 IADTGNNRVLVLTAGGVVQHRIGGHqpGFVDGdltvaRFNNPQGIAFLNENVLIVADTKNHAIRQISLTNAMVETLAGTG 320
Cdd:cd14955   31 VADTGNNRIQKFDSTGTFLTKWGSS--GSGDG-----QFYSPTGIAVDSDGNVYVADTGNHRIQKFDSTGTFLTKWGSSG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 321 IqGNdriggrlgplQPLSSPWDVAIfrtrdmDMSFHL---DERNipektiilismagtHQIWGYFPEGII---WWKFrkf 394
Cdd:cd14955  104 S-GD----------GQFNSPSGIAV------DSAGNVyvtDSGN--------------NRIQKFDSSGTFitkWGSF--- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 395 epcccvsliGNGleenrnnsypqNAAFAQPSGLAI--AGDVlYIADSESSSIRKASmidgkvmpvvgGDRNPLNLFAFGD 472
Cdd:cd14955  150 ---------GSG-----------DGQFNSPTGIAVdsAGNV-YVADTGNNRIQKFT-----------STGTFLTKWGSEG 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 473 IDGRLFSAklqhPLGVTFNDTNNkLYVADTYNHKIKIIDIDSNDISTLqiKSQENTNLILNEPAGLCLDASGrNLLVADT 552
Cdd:cd14955  198 SGDGQFNA----PYGIAVDSAGN-VYVADTGNNRIQKFDSSGTFITKW--GSEGSGDGQFNSPSGIAVDSAG-NVYVADS 269


                 ....*
gi 442622271 553 NNHSI 557
Cdd:cd14955  270 GNNRI 274
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
414-574 8.97e-11

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 63.11  E-value: 8.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 414 SYPQNAAFAQPSGLAIAGD-VLYIADSESSSIRKASMIDGKVmpvvggdrnplnlfafgdidGRLFSAKLQHPLGVTFnD 492
Cdd:COG4257    9 EYPVPAPGSGPRDVAVDPDgAVWFTDQGGGRIGRLDPATGEF--------------------TEYPLGGGSGPHGIAV-D 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 493 TNNKLYVADTYNHKIKIIDIDSNDISTLQIKSQENTnlilnePAGLCLDASGrNLLVADTNNHSIHTIDL----VTLI-- 566
Cdd:COG4257   68 PDGNLWFTDNGNNRIGRIDPKTGEITTFALPGGGSN------PHGIAFDPDG-NLWFTDQGGNRIGRLDPatgeVTEFpl 140

                        170
                 ....*....|..
gi 442622271 567 ----AQPFGLDF 574
Cdd:COG4257  141 ptggAGPYGIAV 152
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 241-557 1.39e-10

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 62.69  E-value: 1.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 241 IADTGNNRVLVLTAGGVVQHRIGGhqPGFVDGdltvaRFNNPQGIAFLNENVLIVADTKNHAIRQISLTNAMVETLAgtg 320
Cdd:cd14963   24 VADTNNHRVQVFDYEGKFKKSFGG--PGTGPG-----EFKYPYGIAVDSDGNIYVADLYNGRIQVFDPDGKFLKYFP--- 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 321 iQGNDRIGgrlgplqpLSSPWDVAIFRTRdmdmsfhldernipektiILISMAGTHQIWGYFPEGiiwwKFRKFepcccv 400
Cdd:cd14963   94 -EKKDRVK--------LISPAGLAIDDGK------------------LYVSDVKKHKVIVFDLEG----KLLLE------ 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 401 slIGNGLEENRNNSYPqnaafaqpSGLAIAGD-VLYIADSESSSIRKASMiDGKVMPVVGGDRNPLNLFAfgdidgrlfs 479
Cdd:cd14963  137 --FGKPGSEPGELSYP--------NGIAVDEDgNIYVADSGNGRIQVFDK-NGKFIKELNGSPDGKSGFV---------- 195

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442622271 480 aklqHPLGVTFnDTNNKLYVADTYNHKIKIIDIDSNDISTLQIKSQENTNLILnePAGLCLDASGRnLLVADTNNHSI 557
Cdd:cd14963  196 ----NPRGIAV-DPDGNLYVVDNLSHRVYVFDEQGKELFTFGGRGKDDGQFNL--PNGLFIDDDGR-LYVTDRENNRV 265
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 262-557 2.89e-10

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 61.53  E-value: 2.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 262 IGGhqPGFVDGdltvaRFNNPQGIAFLNENVLIVADTKNHAIRQISLTNAMVETLAGTGiQGNDRIGgrlgplqplsspw 341
Cdd:cd14956    2 WGG--RGSGPG-----QFKDPRGIAVDADDNVYVADARNGRIQVFDKDGTFLRRFGTTG-DGPGQFG------------- 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 342 dvaifrtRDMDMSFHLDERnipektiILISMAGTHQIWGYFPEGiiwwKFRkfepcccvSLIGNgleenrnnSYPQNAAF 421
Cdd:cd14956   61 -------RPRGLAVDKDGW-------LYVADYWGDRIQVFTLTG----ELQ--------TIGGS--------SGSGPGQF 106

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 422 AQPSGLAIAGD-VLYIADSESSSIRKASMiDGKVmpvvggdrnplnLFAFGDIDGRLFSakLQHPLGVTFNDTNNkLYVA 500
Cdd:cd14956  107 NAPRGVAVDADgNLYVADFGNQRIQKFDP-DGSF------------LRQWGGTGIEPGS--FNYPRGVAVDPDGT-LYVA 170

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442622271 501 DTYNHKIKIIDIDSNDISTLQIKSQENTNliLNEPAGLCLDASGrNLLVADTNNHSI 557
Cdd:cd14956  171 DTYNDRIQVFDNDGAFLRKWGGRGTGPGQ--FNYPYGIAIDPDG-NVFVADFGNNRI 224
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 277-561 2.90e-10

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 61.54  E-value: 2.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 277 ARFNNPQGIAFLNENVLiVADTKNHAIRqisltnamVETLAGTGIQgndRIGGRLGPLQPLSSPWDVAIFRTRDmdmsfh 356
Cdd:cd14963    7 DPLNKPMGVAVSDGRIY-VADTNNHRVQ--------VFDYEGKFKK---SFGGPGTGPGEFKYPYGIAVDSDGN------ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 357 ldernipektiILISMAGTHQIWGYFPEGiiwwKFRKFEPCccvslignglEENRNNsypqnaaFAQPSGLAIAGDVLYI 436
Cdd:cd14963   69 -----------IYVADLYNGRIQVFDPDG----KFLKYFPE----------KKDRVK-------LISPAGLAIDDGKLYV 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 437 ADSESSSIrKASMIDGKVMPVVGGDrnplnlfafGDIDGRLFSaklqhPLGVTFNDtNNKLYVADTYNHKIKIIDIDSND 516
Cdd:cd14963  117 SDVKKHKV-IVFDLEGKLLLEFGKP---------GSEPGELSY-----PNGIAVDE-DGNIYVADSGNGRIQVFDKNGKF 180

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 442622271 517 ISTLQIKSQENTNLILnePAGLCLDASGrNLLVADTNNHSIHTID 561
Cdd:cd14963  181 IKELNGSPDGKSGFVN--PRGIAVDPDG-NLYVVDNLSHRVYVFD 222
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 235-507 7.12e-10

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 60.37  E-value: 7.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 235 PNGLYAIADTGNNRVLVLTAGGVVQHRIG--GHQPGfvdgdltvaRFNNPQGIAFLNENVLIVADTKNHAIRQISLTNAM 312
Cdd:cd14956   69 KDGWLYVADYWGDRIQVFTLTGELQTIGGssGSGPG---------QFNAPRGVAVDADGNLYVADFGNQRIQKFDPDGSF 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 313 VETLAGTGIqgndriggrlgPLQPLSSPWDVAIfrtrdmDMSFHL---DERNipektiilismagtHQIWGYFPEG--II 387
Cdd:cd14956  140 LRQWGGTGI-----------EPGSFNYPRGVAV------DPDGTLyvaDTYN--------------DRIQVFDNDGafLR 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 388 WWKFRkfepcccvsliGNGleenrnnsypqNAAFAQPSGLAIAGD-VLYIADSESSSIRKASMiDGKVMPVVGgdrnpln 466
Cdd:cd14956  189 KWGGR-----------GTG-----------PGQFNYPYGIAIDPDgNVFVADFGNNRIQKFTA-DGTFLTSWG------- 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 442622271 467 lfAFGDIDGRlfsakLQHPLGVTFnDTNNKLYVADTYNHKI 507
Cdd:cd14956  239 --SPGTGPGQ-----FKNPWGVVV-DADGTVYVADSNNNRV 271
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 241-557 1.97e-09

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 59.22  E-value: 1.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 241 IADTGNNRVLVLTAGGVVQHRIGGhqPGfvDGDLTVARfnnPQGIAFLNENVLIVADTKNHAIRqisltnamVETLAGTG 320
Cdd:cd14956   28 VADARNGRIQVFDKDGTFLRRFGT--TG--DGPGQFGR---PRGLAVDKDGWLYVADYWGDRIQ--------VFTLTGEL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 321 IqgndRIGGRLGPLQP-LSSPWDVAIfrtrDMDMSFhlderNIPEktiilismAGTHQIWGYFPEGiiwwkfrkfepccc 399
Cdd:cd14956   93 Q----TIGGSSGSGPGqFNAPRGVAV----DADGNL-----YVAD--------FGNQRIQKFDPDG-------------- 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 400 vSLIGngleenrnnSYPQNAA----FAQPSGLAIAGD-VLYIADSESSSIRKASmIDGKVMPVVGGDRNPLNLFAFgdid 474
Cdd:cd14956  138 -SFLR---------QWGGTGIepgsFNYPRGVAVDPDgTLYVADTYNDRIQVFD-NDGAFLRKWGGRGTGPGQFNY---- 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 475 grlfsaklqhPLGVTFnDTNNKLYVADTYNHKIKIIDIDSNDISTLQIKSQENTNliLNEPAGLCLDASGRnLLVADTNN 554
Cdd:cd14956  203 ----------PYGIAI-DPDGNVFVADFGNNRIQKFTADGTFLTSWGSPGTGPGQ--FKNPWGVVVDADGT-VYVADSNN 268


                 ...
gi 442622271 555 HSI 557
Cdd:cd14956  269 NRV 271
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 418-558 2.70e-09

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 58.82  E-value: 2.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 418 NAAFAQPSGLAI-AGDVLYIADSESSSIR--KASmidGKVMPVVGGDRNPLNLFafgdidgrlfsaklQHPLGVTFnDTN 494
Cdd:cd14957   61 SGQFNSPYGIAVdSNGNIYVADTDNNRIQvfNSS---GVYQYSIGTGGSGDGQF--------------NGPYGIAV-DSN 122

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442622271 495 NKLYVADTYNHKIKIIDIDSNDISTLQIKSQENTNliLNEPAGLCLDASGrNLLVADTNNHSIH 558
Cdd:cd14957  123 GNIYVADTGNHRIQVFTSSGTFSYSIGSGGTGPGQ--FNGPQGIAVDSDG-NIYVADTGNHRIQ 183
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 226-509 3.02e-09

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 58.82  E-value: 3.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 226 RFPAKIVQGPNGLYAIADTGNNRVLVLTAGGVVQHRIGGHqpGFVDGDltvarFNNPQGIAFLNENVLIVADTKNHAIRq 305
Cdd:cd14957   65 NSPYGIAVDSNGNIYVADTDNNRIQVFNSSGVYQYSIGTG--GSGDGQ-----FNGPYGIAVDSNGNIYVADTGNHRIQ- 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 306 isltnamVETLAGTgiqgNDR-IGGRLGPLQPLSSPWDVAIfrtrdmDMSFHldernipektiILISMAGTHQIWGYFPE 384
Cdd:cd14957  137 -------VFTSSGT----FSYsIGSGGTGPGQFNGPQGIAV------DSDGN-----------IYVADTGNHRIQVFTSS 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 385 GIIWwkfrkfepcccvSLIGNGLeenrnnsyPQNAAFAQPSGLAI--AGDVlYIADSESSSIRkasmidgkvmpVVGGDR 462
Cdd:cd14957  189 GTFQ------------YTFGSSG--------SGPGQFSDPYGIAVdsDGNI-YVADTGNHRIQ-----------VFTSSG 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 442622271 463 NPLNLFAFGDIDGRLFSaklqHPLGVTFnDTNNKLYVADTYNHKIKI 509
Cdd:cd14957  237 AYQYSIGTSGSGNGQFN----YPYGIAV-DNDGKIYVADSNNNRIQV 278
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 278-557 3.49e-09

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 58.43  E-value: 3.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 278 RFNNPQGIAFLNENVLIVADTKNHAIrQISLTNAMVETLAGTGIQGNDRIggrlgplqplSSPWDVAIFRTRDmdmsfhl 357
Cdd:cd14957   16 QFNTPRGIAVDSAGNIYVADTGNNRI-QVFTSSGVYSYSIGSGGTGSGQF----------NSPYGIAVDSNGN------- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 358 dernipektiILISMAGTHQIWGYFPEGIIWwkfrkfepcccvSLIGNGleenrNNSYPQnaaFAQPSGLAI--AGDVlY 435
Cdd:cd14957   78 ----------IYVADTDNNRIQVFNSSGVYQ------------YSIGTG-----GSGDGQ---FNGPYGIAVdsNGNI-Y 126

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 436 IADSESSSIrkasmidgKVMPVVGGdrnplNLFAFGDidGRLFSAKLQHPLGVTFnDTNNKLYVADTYNHKIKIIDIDSN 515
Cdd:cd14957  127 VADTGNHRI--------QVFTSSGT-----FSYSIGS--GGTGPGQFNGPQGIAV-DSDGNIYVADTGNHRIQVFTSSGT 190

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 442622271 516 DISTlqIKSQENTNLILNEPAGLCLDASGrNLLVADTNNHSI 557
Cdd:cd14957  191 FQYT--FGSSGSGPGQFSDPYGIAVDSDG-NIYVADTGNHRI 229
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
216-514 6.93e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 57.34  E-value: 6.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 216 FNDFQPASNLRfPAKIVQGPNGLYAIADTGNNRVLVLTAggvvqhrigghqpgfVDGDLTV----ARFNNPQGIAFLNEN 291
Cdd:COG4257   50 FTEYPLGGGSG-PHGIAVDPDGNLWFTDNGNNRIGRIDP---------------KTGEITTfalpGGGSNPHGIAFDPDG 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 292 VLIVADTKNHAIRQISLTNAMVETLAGTGIQGNdriggrlgplqplssPWDVAIfrtrDmdmsfhldernipektiilis 371
Cdd:COG4257  114 NLWFTDQGGNRIGRLDPATGEVTEFPLPTGGAG---------------PYGIAV----D--------------------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 372 magthqiwgyfPEGIIWW------KFRKFEPcccvslignglEENRNNSYPQNAAFAQPSGLAIAGD-VLYIADSESSSI 444
Cdd:COG4257  154 -----------PDGNLWVtdfganAIGRIDP-----------DTGTLTEYALPTPGAGPRGLAVDPDgNLWVADTGSGRI 211

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 445 RKASMIDGKVMPVVGGDRNPlnlfafgdidgrlfsaklqHPLGVTFnDTNNKLYVADTYNHKIKIIDIDS 514
Cdd:COG4257  212 GRFDPKTGTVTEYPLPGGGA-------------------RPYGVAV-DGDGRVWFAESGANRIVRFDPDT 261
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 414-557 1.09e-08

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 56.82  E-value: 1.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 414 SYPQNAAFAQPSGLAI--AGDVlYIADSESSSIRKASMiDGKVMPVVGGdrnplnlfaFGDIDGRLFSaklqhPLGVTFn 491
Cdd:cd14955    8 YGSGDGQFNSPSGIAVdsAGNV-YVADTGNNRIQKFDS-TGTFLTKWGS---------SGSGDGQFYS-----PTGIAV- 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442622271 492 DTNNKLYVADTYNHKIKIIDIDSNDIStlQIKSQENTNLILNEPAGLCLDASGrNLLVADTNNHSI 557
Cdd:cd14955   71 DSDGNVYVADTGNHRIQKFDSTGTFLT--KWGSSGSGDGQFNSPSGIAVDSAG-NVYVTDSGNNRI 133
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 225-345 1.26e-08

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 56.89  E-value: 1.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 225 LRFPAKIVQGPNGLYAIADTGNNRVLVLTAGGVVQHRIGghqpgfvDGDLTVARFNNPQGIAFLNENVLIVADTKNHAIR 304
Cdd:cd14957  111 FNGPYGIAVDSNGNIYVADTGNHRIQVFTSSGTFSYSIG-------SGGTGPGQFNGPQGIAVDSDGNIYVADTGNHRIQ 183

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 442622271 305 QISLTNAMVETLAGTGIqgndriggrlGPLQpLSSPWDVAI 345
Cdd:cd14957  184 VFTSSGTFQYTFGSSGS----------GPGQ-FSDPYGIAV 213
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
419-565 1.33e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.24  E-value: 1.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 419 AAFAQPSGLAIAGDVLYIADSESSSIRKASMIDGKVMPVVGGDRNPLNLFAFGDIDGRLFSAKLQHPLGVTFNDTNNKLY 498
Cdd:COG3391    4 ASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLY 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442622271 499 VADTYNHKIKIIDIDSNDISTlQIKSQENtnlilnePAGLCLDASGRNLLVADTNNHSIHTIDLVTL 565
Cdd:COG3391   84 VANSGSGRVSVIDLATGKVVA-TIPVGGG-------PRGLAVDPDGGRLYVADSGNGRVSVIDTATG 142
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 226-361 1.60e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 56.52  E-value: 1.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 226 RFPAKIVQGPNGLYAIADTGNNRVLVLTAGGVVQHRIG--GHQPGfvdgdltvaRFNNPQGIAFLNENVLIVADTKNHAI 303
Cdd:cd14956  107 NAPRGVAVDADGNLYVADFGNQRIQKFDPDGSFLRQWGgtGIEPG---------SFNYPRGVAVDPDGTLYVADTYNDRI 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 304 RQISLTNAMVETLAGTGIQ-----------------------GNDRI----------------GGRLGPLQplsSPWDVA 344
Cdd:cd14956  178 QVFDNDGAFLRKWGGRGTGpgqfnypygiaidpdgnvfvadfGNNRIqkftadgtfltswgspGTGPGQFK---NPWGVV 254

                        170
                 ....*....|....*..
gi 442622271 345 IFRTRDMdmsFHLDERN 361
Cdd:cd14956  255 VDADGTV---YVADSNN 268
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 235-340 5.91e-08

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 55.28  E-value: 5.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 235 PNGLYAIADTGNNRVLVL-TAGGVVQHRIGGHQPGFVDGDltvARFNNPQGIAFLNENVLIVADTKNHAIRQISL-TNAM 312
Cdd:cd14951  205 PDGSVYVADTYNHKIKRVdPATGEVSTLAGTGKAGYKDLE---AQFSEPSGLVVDGDGRLYVADTNNHRIRRLDLpTEAL 281

                         90       100       110
                 ....*....|....*....|....*....|
gi 442622271 313 -VETLAGTGIQGNDRIG-GRLGPLQPLSSP 340
Cdd:cd14951  282 eVLTLAHRTLRPATPPApGPLRLRVRFTAP 311
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 485-558 1.38e-07

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 53.42  E-value: 1.38e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442622271 485 PLGVTFnDTNNKLYVADTYNHKIKIIDIDSNDISTlqIKSQENTNLILNEPAGLCLDASGrNLLVADTNNHSIH 558
Cdd:cd14957   20 PRGIAV-DSAGNIYVADTGNNRIQVFTSSGVYSYS--IGSGGTGSGQFNSPYGIAVDSNG-NIYVADTDNNRIQ 89
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 220-322 1.67e-07

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 53.42  E-value: 1.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 220 QPASNLRFPAKIVQGPNGLYAIADTGNNRVLVLTAGGVVQHRIGGhqPGFVDGDltvarFNNPQGIAFLNENVLIVADTK 299
Cdd:cd14957  153 TGPGQFNGPQGIAVDSDGNIYVADTGNHRIQVFTSSGTFQYTFGS--SGSGPGQ-----FSDPYGIAVDSDGNIYVADTG 225

                         90       100
                 ....*....|....*....|...
gi 442622271 300 NHAIRQISLTNAMVETLAGTGIQ 322
Cdd:cd14957  226 NHRIQVFTSSGAYQYSIGTSGSG 248
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 421-561 1.75e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 53.06  E-value: 1.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 421 FAQPSGLAIAGD-VLYIADSESSSIRKASMiDGKVMpVVGGDRNPLNlfafGDIDGrlfsaklqhPLGVTFNDTNNkLYV 499
Cdd:cd14956   59 FGRPRGLAVDKDgWLYVADYWGDRIQVFTL-TGELQ-TIGGSSGSGP----GQFNA---------PRGVAVDADGN-LYV 122

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442622271 500 ADTYNHKIKIIDIDSNDISTLQIKSQENTNLilNEPAGLCLDASGrNLLVADTNNHSIHTID 561
Cdd:cd14956  123 ADFGNQRIQKFDPDGSFLRQWGGTGIEPGSF--NYPRGVAVDPDG-TLYVADTYNDRIQVFD 181
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 235-303 2.25e-07

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 52.94  E-value: 2.25e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442622271 235 PNGLYAIADTGNNRVLVLTAGGVVQHRIG--GHQPGfvdgdltvaRFNNPQGIAFLNENVLIVADTKNHAI 303
Cdd:cd14954  127 SEGRIYVSDTRNHRVQVFDSDGQFIRKFGfeGAGPG---------QLDSPRGVAVNPDGNIVVSDFNNHRL 188
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 416-562 2.83e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 52.68  E-value: 2.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 416 PQNAAFAQPSGLAIAGDVLYIADSESSSIRkasmidgkVMpvvggDRNPLNLFAFGDIDGrlFSAKLQHPLGVTFnDTNN 495
Cdd:cd14963    4 PFGDPLNKPMGVAVSDGRIYVADTNNHRVQ--------VF-----DYEGKFKKSFGGPGT--GPGEFKYPYGIAV-DSDG 67

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442622271 496 KLYVADTYNHKIKIIDIDSNDISTLQIKSQENTnliLNEPAGLCLDasGRNLLVADTNNHSIHTIDL 562
Cdd:cd14963   68 NIYVADLYNGRIQVFDPDGKFLKYFPEKKDRVK---LISPAGLAID--DGKLYVSDVKKHKVIVFDL 129
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 223-306 3.19e-07

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 52.55  E-value: 3.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 223 SNLRFPAKIVQGPNGLYAIADTGNNRVLVLTAGGVVQHRIGGhqPGFVDGdltvaRFNNPQGIAFLNENVLIVADTKNHA 302
Cdd:cd14954  162 GQLDSPRGVAVNPDGNIVVSDFNNHRLQVFDPDGQFLRFFGS--EGSGNG-----QFKRPRGVAVDDEGNIIVADSGNHR 234


                 ....
gi 442622271 303 IrQI 306
Cdd:cd14954  235 V-QV 237
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 224-325 9.14e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 51.14  E-value: 9.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 224 NLRFPAKIVQGPNGLYAIADTGNNRVLVLTAGGVVQHRIGGhqpgfvdGDLTVARFNNPQGIAFLNENVLIVADTKNHAI 303
Cdd:cd14963  146 ELSYPNGIAVDEDGNIYVADSGNGRIQVFDKNGKFIKELNG-------SPDGKSGFVNPRGIAVDPDGNLYVVDNLSHRV 218

                         90       100
                 ....*....|....*....|..
gi 442622271 304 RQISLTNAMVETLagtGIQGND 325
Cdd:cd14963  219 YVFDEQGKELFTF---GGRGKD 237
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 224-303 9.80e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 51.13  E-value: 9.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 224 NLRFPAKIVQGPNGLYAIADTGNNRVLVLTAGGVVQHRIG--GHQPGfvdgdltvaRFNNPQGIAFLNENVLIVADTKNH 301
Cdd:cd14956  199 QFNYPYGIAIDPDGNVFVADFGNNRIQKFTADGTFLTSWGspGTGPG---------QFKNPWGVVVDADGTVYVADSNNN 269


                 ..
gi 442622271 302 AI 303
Cdd:cd14956  270 RV 271
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 418-561 1.00e-06

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 51.01  E-value: 1.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 418 NAAFAQPSGLAIAG-DVLYIADSESSSIRKASMiDGKVmpvvggdrnplnLFAFGDiDGRLfSAKLQHPLGVTFnDTNNK 496
Cdd:cd14954   67 DGQFDRPAGVAVNSrGRIIVADKDNHRIQVFDL-NGRF------------LLKFGE-RGTK-NGQFNYPWGVAV-DSEGR 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442622271 497 LYVADTYNHKIKIIDIDSNDIStlqiKSQENTNLI--LNEPAGLCLDASGrNLLVADTNNHSIHTID 561
Cdd:cd14954  131 IYVSDTRNHRVQVFDSDGQFIR----KFGFEGAGPgqLDSPRGVAVNPDG-NIVVSDFNNHRLQVFD 192
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 278-513 3.20e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 49.51  E-value: 3.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 278 RFNNPQGIAFLNENVLIVADTKNHAIRQISLTNAMVetlagtgiqgnDRIGGRLGplQPLSSPWDVAIfrtrdmdmsfhl 357
Cdd:cd14962   10 ALTRPYGVAADGRGRIYVADTGRGAVFVFDLPNGKV-----------FVIGNAGP--NRFVSPIGVAI------------ 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 358 DerniPEKTIiLISMAGTHQIWGYFPEGiiwwKFRKFepcccvslIGNGLEENRnnsypqnaafaqPSGLAI--AGDVLY 435
Cdd:cd14962   65 D----ANGNL-YVSDAELGKVFVFDRDG----KFLRA--------IGAGALFKR------------PTGIAVdpAGKRLY 115

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442622271 436 IADSESSSIRKASMiDGKVMPVVGGDrnplnlfafGDIDGRLFsaklqHPLGVTFNDtNNKLYVADTYNHKIKIIDID 513
Cdd:cd14962  116 VVDTLAHKVKVFDL-DGRLLFDIGKR---------GSGPGEFN-----LPTDLAVDR-DGNLYVTDTMNFRVQIFDAD 177
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 205-303 4.12e-06

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 49.08  E-value: 4.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 205 IIDHRGLPLKLF-----NDFQpasnLRFPAKIVQGPNGLYAIADTGNNRVLVLTAGGVVQHRIGGHQPGFvdgdltvARF 279
Cdd:cd14954  190 VFDPDGQFLRFFgsegsGNGQ----FKRPRGVAVDDEGNIIVADSGNHRVQVFSPDGEFLCSFGTEGNGE-------GQF 258

                         90       100
                 ....*....|....*....|....
gi 442622271 280 NNPQGIAFLNENVLIVADTKNHAI 303
Cdd:cd14954  259 DRPSGVAVTPDGRIVVVDRGNHRI 282
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 221-555 1.03e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 47.59  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 221 PASNLRFPAKIVQGPNG-LYaIADTGNNRVLVLTAGGVVQhrigghqpgfvdgdlTVARFN---NPQGIAFLNENVLIVA 296
Cdd:cd14952    5 PFTGLDGPGGVAVDAAGnVY-VADSGNNRVLKLAAGSTTQ---------------TVLPFTglyQPQGVAVDAAGTVYVT 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 297 DTKNhairqisltNAMVETLAGTGIQgndriggRLGPLQPLSSPWDVAIFRTRDMDMSFHLDERnipektiILISMAGTh 376
Cdd:cd14952   69 DFGN---------NRVLKLAAGSTTQ-------TVLPFTGLNDPTGVAVDAAGNVYVADTGNNR-------VLKLAAGS- 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 377 qiwgyfpegiiwwkfrkfepcccvsligngleenrnnSYPQNAAFA---QPSGLAI--AGDVlYIADSESSsirkasmid 451
Cdd:cd14952  125 -------------------------------------NTQTVLPFTglsNPDGVAVdgAGNV-YVTDTGNN--------- 157

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 452 gKVMPVVGGDRNPLNLfAFGDidgrlfsakLQHPLGVTFNDTNNkLYVADTYNHKIKIIDIDSNDISTLQIKSqentnli 531
Cdd:cd14952  158 -RVLKLAAGSTTQTVL-PFTG---------LNSPSGVAVDTAGN-VYVTDHGNNRVLKLAAGSTTPTVLPFTG------- 218

                        330       340
                 ....*....|....*....|....
gi 442622271 532 LNEPAGLCLDASGrNLLVADTNNH 555
Cdd:cd14952  219 LNGPLGVAVDAAG-NVYVADRGND 241
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
423-515 2.51e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 46.23  E-value: 2.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 423 QPSGLAI--AGDVLYIADSESSSIRKASMIDGKVMPVVGGDRNPLNLfAFGDIDGRLFSA-------------------- 480
Cdd:COG3391  111 GPRGLAVdpDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGI-AVDPDGKRLYVAnsgsntvsvivsvidtatgk 189

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 442622271 481 ------KLQHPLGVTFNDTNNKLYVADTYN-------HKIKIIDIDSN 515
Cdd:COG3391  190 vvatipVGGGPVGVAVSPDGRRLYVANRGSntsnggsNTVSVIDLATL 237
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 476-575 1.34e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.11  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 476 RLFSAKLQHPLGVTFnDTNNKLYVADTYNHKIKIIDIDSNDISTLQIKSqentnlilNEPAGLCLDASGRnLLVADTnNH 555
Cdd:COG3386    1 KLADAGFRLGEGPVW-DPDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS--------GRPNGLAFDPDGR-LLVADH-GR 69

                         90       100
                 ....*....|....*....|....
gi 442622271 556 SIHTIDL----VTLIAQPFGLDFR 575
Cdd:COG3386   70 GLVRFDPadgeVTVLADEYGKPLN 93
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 482-593 2.15e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 43.73  E-value: 2.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 482 LQHPLGVTFnDTNNKLYVADTYNHKIKIIDIDSNDISTlqIKSQENTNLIlnEPAGLCLDASGrNLLVADTNNHSIhtid 561
Cdd:cd14962   11 LTRPYGVAA-DGRGRIYVADTGRGAVFVFDLPNGKVFV--IGNAGPNRFV--SPIGVAIDANG-NLYVSDAELGKV---- 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 442622271 562 LVtliaqpFGLDFRQIAsasEIDAPQDTQKPT 593
Cdd:cd14962   81 FV------FDRDGKFLR---AIGAGALFKRPT 103
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 422-557 3.55e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 42.97  E-value: 3.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 422 AQPSGLAI--AGDVlYIADSesssirkasmIDGKVMPVVGGDRNPLNLfAFGDidgrlfsakLQHPLGVTFNDTNNkLYV 499
Cdd:cd14952   94 NDPTGVAVdaAGNV-YVADT----------GNNRVLKLAAGSNTQTVL-PFTG---------LSNPDGVAVDGAGN-VYV 151

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442622271 500 ADTYNHKIKIIDIDSNDISTLQIKSqentnliLNEPAGLCLDASGrNLLVADTNNHSI 557
Cdd:cd14952  152 TDTGNNRVLKLAAGSTTQTVLPFTG-------LNSPSGVAVDTAG-NVYVTDHGNNRV 201
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 492-561 5.05e-04

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 42.72  E-value: 5.05e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 492 DTNNKLYVADTYNHKIKIIDIDSNdiSTLQIKSQENTNLILNEPAGLCLDASGrNLLVADTNNHSIHTID 561
Cdd:cd14960  161 NNNNEIIVTDFHNHSVKVFNAEGE--FLFKFGSNGEGNGQFNAPTGVAVDSNG-NIIVADWGNSRIQVFD 227
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 228-509 6.65e-04

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 42.26  E-value: 6.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 228 PAKIVQGPNGLYAIADTGNNRVLVLTAGGVVQHRIG-GHQPGFV------------------------------DGDLTV 276
Cdd:cd14961   13 PTGVAVTPTGRVVVADDGNKRIQVFDSDGNCLQQFGpKGDAGQDirypldvavtpdghivvtdagdrsvkvfsfDGRLKL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 277 A---RFNNPQGIAFLNENVLIVADTKNHAIrqisltnAMVETLAGTGIQGNdriGGRLGPlqPLSSPWDVAIFRTRDMDM 353
Cdd:cd14961   93 FvrkSFSLPWGVAVNPSGEILVTDSEAGKL-------FVLTVDFKLGILKK---GQKLCS--QLCRPRFVAVSRLGAVAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 354 SFHLdernipektIILISMAGTHQIWGYFPEGIIWWkfrkfepccCVSLIGNGLeenrnnsypQNAAFAQPSGLAIA--G 431
Cdd:cd14961  161 TEHL---------FANGTRSSSTRVKVFSSGGQLLG---------QIDSFGLNL---------VFPSLICASGVAFDseG 213

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442622271 432 DVLyIADSESSSIrkasMIDGKvmpvvGGDRNPLNlfafgdidgRLFSAKLQHPLGVTFNdTNNKLYVADTYNHKIKI 509
Cdd:cd14961  214 NVI-VADTGSGAI----LCLGK-----PEGFPILK---------PIVTQGLSRPVGLAVT-PDGSLVVLDSGNHCVKI 271
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 235-303 1.39e-03

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 41.18  E-value: 1.39e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442622271 235 PNGLYAIADTGNNRVLVLTAGGVVQHRIGGhqpgfvdgdlTVARFNNPQGIAFLNENVLIVADTKNHAI 303
Cdd:cd14960  209 SNGNIIVADWGNSRIQVFDSSGSFLSYINT----------SADPLYGPQGLALTSDGHVVVADSGNHCF 267
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 485-562 2.12e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 40.73  E-value: 2.12e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442622271 485 PLGVTFnDTNNKLYVADTYNHKIKIIDIDSNDISTLQIKSQENTNLIlnEPAGLCLDASGrNLLVADTNNHSIHTIDL 562
Cdd:cd14956   15 PRGIAV-DADDNVYVADARNGRIQVFDKDGTFLRRFGTTGDGPGQFG--RPRGLAVDKDG-WLYVADYWGDRIQVFTL 88
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 423-558 2.32e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 40.65  E-value: 2.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 423 QPSGLAIAGD-VLYIADSeSSSIRKASMIDGKVMPVVGGDRNPLNLFAFGDID--GRLF------------------SAK 481
Cdd:COG3386   50 RPNGLAFDPDgRLLVADH-GRGLVRFDPADGEVTVLADEYGKPLNRPNDGVVDpdGRLYftdmgeylptgalyrvdpDGS 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 482 LQHPL-------GVTFNDTNNKLYVADTYNHKIKIIDIDSN-DISTLQIKSQENTNLILnePAGLCLDASGrNLLVADTN 553
Cdd:COG3386  129 LRVLAdgltfpnGIAFSPDGRTLYVADTGAGRIYRFDLDADgTLGNRRVFADLPDGPGG--PDGLAVDADG-NLWVALWG 205


                 ....*
gi 442622271 554 NHSIH 558
Cdd:COG3386  206 GGGVV 210
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 238-300 2.33e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 40.65  E-value: 2.33e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442622271 238 LYaIADTGNNRVLVLTAGGVVQHRIG--GHQPGfvdgdltvaRFNNPQGIAFLNENVLIVADTKN 300
Cdd:cd14962  114 LY-VVDTLAHKVKVFDLDGRLLFDIGkrGSGPG---------EFNLPTDLAVDRDGNLYVTDTMN 168
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 279-305 4.10e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 35.07  E-value: 4.10e-03
                          10        20
                  ....*....|....*....|....*..
gi 442622271  279 FNNPQGIAFLNENVLIVADTKNHAIRQ 305
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQV 27
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 228-303 4.78e-03

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 39.55  E-value: 4.78e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442622271 228 PAKIVQGPNGLYAIADT-GNNRVLVLTAGGVVQHRIGghQPGFVDGDltvarFNNPQGIAFLNENVLIVADTKNHAI 303
Cdd:cd14958  130 PTDVAVAPDGDIFVADGyCNSRIVKFSPDGKLLKSWG--EPGSGPGQ-----FNLPHSIALDEDGRVYVADRENGRI 199
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 421-554 5.68e-03

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 39.25  E-value: 5.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271 421 FAQPSGLAIAGDV-LYIADSESSSIRkasmidgkvMPVVGGDrnplNLFAFGdIDGRLFSAkLQHPLGVTFnDTNNKLYV 499
Cdd:cd14960   16 FTNLQGVAASSSGrLVIADSNNQCVQ---------VFSNDGQ----FKLRFG-VRGRSPGQ-LQRPTGVAV-TLNGDIII 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 442622271 500 ADTYNHKIKIIDIDsndistLQIKSQENTNLILNePAGLCLDASGrNLLVADTNN 554
Cdd:cd14960   80 ADYDNKWVSIFSPD------GKFKSKIGAGKLMG-PKGVAVDRNG-HIIVVDNKA 126
AhpC-TSA pfam00578
AhpC/TSA family; This family contains proteins related to alkyl hydroperoxide reductase (AhpC) ...
 72-175 8.00e-03

AhpC/TSA family; This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA).


Pssm-ID: 425763 [Multi-domain]  Cd Length: 124  Bit Score: 37.20  E-value: 8.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622271   72 PLSIKGLQGKVIILDFftYCCINCMHVLQELHLLEERFP--IESGVVVIGVhSPKfenerNAANILSAVQRYGISHPIVN 149
Cdd:pfam00578  17 TVSLSDYRGKWVVLFF--YPADWTPVCTTELPALADLYEefKKLGVEVLGV-SVD-----SPESHKAFAEKYGLPFPLLS 88

                          90       100       110
                  ....*....|....*....|....*....|..
gi 442622271  150 DSRSGMWRALGIR------CWPSLLILSPTGV 175
Cdd:pfam00578  89 DPDGEVARAYGVLneeeggALRATFVIDPDGK 120
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 532-557 8.68e-03

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 38.79  E-value: 8.68e-03
                         10        20
                 ....*....|....*....|....*.
gi 442622271 532 LNEPAGLCLDASGrNLLVADTNNHSI 557
Cdd:cd14959   21 FNSPSGFCLGEDE-DILVADTNNHRI 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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