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Conserved domains on  [gi|442622557|ref|NP_001260742|]
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coronin, isoform D [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-491 2.59e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 277.93  E-value: 2.59e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557   9 SKFRHVYGQALKREQCYDNIRVSKSSWD-STFCAVNPKFLAIIVESAGGGAfiVLPHNkvgrmwQVGRIAADHPLVGGHK 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHT------DYGKLASNPPILLGQE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557  88 GPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFHQRRVGLVLWHPSALNVLLTAGSDNQVVIWNV 167
Cdd:PTZ00421  76 GPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 168 GTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGSKATRAIFL-RHGLIFTTGFNRSS 246
Cdd:PTZ00421 156 ERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAkRKDLIITLGCSKSQ 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 247 ERQYSLRAPDALNEPIVMVELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYinTFQTTEPQRGIGLMP 326
Cdd:PTZ00421 236 QRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 327 KRGCDVTTCEVAKFYRMNNNGLCQvISMTVPRK-SDL-FQEDLYPDTLAEDAAITAEEWIDGKDADPITFSLkggyvsSS 404
Cdd:PTZ00421 314 KWSLDTRKCEIARFYALTYHSLYT-IQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM------SA 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 405 VNKSLPAKKAGNILNKPRGDSASSGATSSSAGGGNFASGNNNEASEGGPPAAVLSEKDLRTIQDEIRKLKAIIVK---QE 481
Cdd:PTZ00421 387 VFDGTSPELMGASALSPSGKPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQALSEKlrtQH 466

                        490
                 ....*....|....
gi 442622557 482 NRI----RALEAKE 491
Cdd:PTZ00421 467 EEIkrcrEALQKKE 480
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-491 2.59e-87

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 277.93  E-value: 2.59e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557   9 SKFRHVYGQALKREQCYDNIRVSKSSWD-STFCAVNPKFLAIIVESAGGGAfiVLPHNkvgrmwQVGRIAADHPLVGGHK 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHT------DYGKLASNPPILLGQE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557  88 GPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFHQRRVGLVLWHPSALNVLLTAGSDNQVVIWNV 167
Cdd:PTZ00421  76 GPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 168 GTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGSKATRAIFL-RHGLIFTTGFNRSS 246
Cdd:PTZ00421 156 ERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAkRKDLIITLGCSKSQ 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 247 ERQYSLRAPDALNEPIVMVELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYinTFQTTEPQRGIGLMP 326
Cdd:PTZ00421 236 QRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 327 KRGCDVTTCEVAKFYRMNNNGLCQvISMTVPRK-SDL-FQEDLYPDTLAEDAAITAEEWIDGKDADPITFSLkggyvsSS 404
Cdd:PTZ00421 314 KWSLDTRKCEIARFYALTYHSLYT-IQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM------SA 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 405 VNKSLPAKKAGNILNKPRGDSASSGATSSSAGGGNFASGNNNEASEGGPPAAVLSEKDLRTIQDEIRKLKAIIVK---QE 481
Cdd:PTZ00421 387 VFDGTSPELMGASALSPSGKPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQALSEKlrtQH 466

                        490
                 ....*....|....
gi 442622557 482 NRI----RALEAKE 491
Cdd:PTZ00421 467 EEIkrcrEALQKKE 480
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 4.76e-39

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 136.47  E-value: 4.76e-39
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442622557    4 RVVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHNKVGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 COG2319
WD40 repeat [General function prediction only];
69-214 1.70e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 1.70e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557  69 RMWQVGRIAADHPLvGGHKGPVLDIAWCPhNDNVIASGSEDCVVKVWQIPDGGLSRTLTepvvdlvFHQRRVGLVLWHPS 148
Cdd:COG2319  187 RLWDLATGKLLRTL-TGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLT-------GHSGSVRSVAFSPD 257

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442622557 149 AlNVLLTAGSDNQVVIWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAEL 214
Cdd:COG2319  258 G-RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 85-300 3.55e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 3.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557  85 GHKGPVLDIAWCPHnDNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvdlvfHQRRVGLVLWHPSaLNVLLTAGSDNQVVI 164
Cdd:cd00200   49 GHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETGECVRTLTG-------HTSYVSSVAFSPD-GRILSSSSRDKTIKV 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 165 WNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGSkATRAIFLRHGLIFTTGFNR 244
Cdd:cd00200  120 WDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAFSPDGEKLLSSSSD 198

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442622557 245 SSERQYSLRAPDALNEPIVMveldtSNGVMFPLYDADTNMIyLCGKGDSVIRYFEV 300
Cdd:cd00200  199 GTIKLWDLSTGKCLGTLRGH-----ENGVNSVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-115 1.42e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.42e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 442622557    85 GHKGPVLDIAWCPhNDNVIASGSEDCVVKVW 115
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-491 2.59e-87

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 277.93  E-value: 2.59e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557   9 SKFRHVYGQALKREQCYDNIRVSKSSWD-STFCAVNPKFLAIIVESAGGGAfiVLPHNkvgrmwQVGRIAADHPLVGGHK 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHT------DYGKLASNPPILLGQE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557  88 GPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFHQRRVGLVLWHPSALNVLLTAGSDNQVVIWNV 167
Cdd:PTZ00421  76 GPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 168 GTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGSKATRAIFL-RHGLIFTTGFNRSS 246
Cdd:PTZ00421 156 ERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAkRKDLIITLGCSKSQ 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 247 ERQYSLRAPDALNEPIVMVELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYinTFQTTEPQRGIGLMP 326
Cdd:PTZ00421 236 QRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 327 KRGCDVTTCEVAKFYRMNNNGLCQvISMTVPRK-SDL-FQEDLYPDTLAEDAAITAEEWIDGKDADPITFSLkggyvsSS 404
Cdd:PTZ00421 314 KWSLDTRKCEIARFYALTYHSLYT-IQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM------SA 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 405 VNKSLPAKKAGNILNKPRGDSASSGATSSSAGGGNFASGNNNEASEGGPPAAVLSEKDLRTIQDEIRKLKAIIVK---QE 481
Cdd:PTZ00421 387 VFDGTSPELMGASALSPSGKPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQALSEKlrtQH 466

                        490
                 ....*....|....
gi 442622557 482 NRI----RALEAKE 491
Cdd:PTZ00421 467 EEIkrcrEALQKKE 480
PTZ00420 PTZ00420
coronin; Provisional
 25-397 9.06e-59

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 204.41  E-value: 9.06e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557  25 YDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHNKVGRMWQVGRIAadhplvgGHKGPVLDIAWCPHNDNVIA 104
Cdd:PTZ00420  19 FDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMRKPPVIKLK-------GHTSSILDLQFNPCFSEILA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 105 SGSEDCVVKVWQIPDGGLS-RTLTEPVVDLVFHQRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHIDShPDIV 183
Cdd:PTZ00420  92 SGSEDLTIRVWEIPHNDESvKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINM-PKKL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 184 YSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGSKATRAIFLrHGL------IFTTGFNRSSERQYSLRAPDA 257
Cdd:PTZ00420 171 SSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNTKNIWI-DGLggddnyILSTGFSKNNMREMKLWDLKN 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 258 LNEPIVMVELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPpfVHYINTFQTTEPQRGIGLMPKRGCDVTTCEV 337
Cdd:PTZ00420 250 TTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCEI 327

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442622557 338 AKFYRMNNNGLCQVISMTVPRK-SDLFQEDLYPDTLAEDAAITAEEWIDGKDADPITFSLK 397
Cdd:PTZ00420 328 GRVYKNENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIK 388
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 4.76e-39

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 136.47  E-value: 4.76e-39
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442622557    4 RVVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHNKVGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 COG2319
WD40 repeat [General function prediction only];
69-214 1.70e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 1.70e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557  69 RMWQVGRIAADHPLvGGHKGPVLDIAWCPhNDNVIASGSEDCVVKVWQIPDGGLSRTLTepvvdlvFHQRRVGLVLWHPS 148
Cdd:COG2319  187 RLWDLATGKLLRTL-TGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLT-------GHSGSVRSVAFSPD 257

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442622557 149 AlNVLLTAGSDNQVVIWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAEL 214
Cdd:COG2319  258 G-RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
53-214 2.52e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.30  E-value: 2.52e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557  53 SAGGGAFIVLPHNKVGRMWQVGRIAADHPLVGgHKGPVLDIAWCPhNDNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvd 132
Cdd:COG2319   87 SPDGRLLASASADGTVRLWDLATGLLLRTLTG-HTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTG---- 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 133 lvfHQRRVGLVLWHPSAlNVLLTAGSDNQVVIWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTA 212
Cdd:COG2319  161 ---HSGAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236


                 ..
gi 442622557 213 EL 214
Cdd:COG2319  237 KL 238
WD40 COG2319
WD40 repeat [General function prediction only];
69-211 4.16e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 4.16e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557  69 RMWQV--GRIAAdhpLVGGHKGPVLDIAWCPhNDNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvdlvfHQRRVGLVLWH 146
Cdd:COG2319  271 RLWDLatGELLR---TLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG-------HTGAVRSVAFS 339

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442622557 147 PSAlNVLLTAGSDNQVVIWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRT 211
Cdd:COG2319  340 PDG-KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 85-300 3.55e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 3.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557  85 GHKGPVLDIAWCPHnDNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvdlvfHQRRVGLVLWHPSaLNVLLTAGSDNQVVI 164
Cdd:cd00200   49 GHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETGECVRTLTG-------HTSYVSSVAFSPD-GRILSSSSRDKTIKV 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 165 WNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGSkATRAIFLRHGLIFTTGFNR 244
Cdd:cd00200  120 WDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAFSPDGEKLLSSSSD 198

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442622557 245 SSERQYSLRAPDALNEPIVMveldtSNGVMFPLYDADTNMIyLCGKGDSVIRYFEV 300
Cdd:cd00200  199 GTIKLWDLSTGKCLGTLRGH-----ENGVNSVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 85-224 3.69e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 3.69e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557  85 GHKGPVLDIAWCPHNdNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvdlvfHQRRVGLVLWHPSAlNVLLTAGSDNQVVI 164
Cdd:cd00200    7 GHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKG-------HTGPVRDVAASADG-TYLASGSSDKTIRL 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 165 WNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGS 224
Cdd:cd00200   78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW 137
WD40 COG2319
WD40 repeat [General function prediction only];
69-214 4.42e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.44  E-value: 4.42e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557  69 RMWQVGRIAADHPLvGGHKGPVLDIAWCPhNDNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvdlvfHQRRVGLVLWHPS 148
Cdd:COG2319  229 RLWDLATGKLLRTL-TGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTG-------HSGGVNSVAFSPD 299

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442622557 149 AlNVLLTAGSDNQVVIWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAEL 214
Cdd:COG2319  300 G-KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 85-224 5.91e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 5.91e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557  85 GHKGPVLDIAWCPHNDnVIASGSEDCVVKVWQIPDGGLSRTLTepvvdlvFHQRRVGLVLWHPSaLNVLLTAGSDNQVVI 164
Cdd:cd00200  133 GHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATLT-------GHTGEVNSVAFSPD-GEKLLSSSSDGTIKL 203

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442622557 165 WNVGTGEILVHIDSHPDIVYSACFNWDGsKLVTTC-KDKKIRIYDPRTAELESEAMCHEGS 224
Cdd:cd00200  204 WDLSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGsEDGTIRVWDLRTGECVQTLSGHTNS 263
WD40 COG2319
WD40 repeat [General function prediction only];
53-214 1.22e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 1.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557  53 SAGGGAFIVLPHNKVGRMWQVGRIAADHPLvGGHKGPVLDIAWCPhNDNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvd 132
Cdd:COG2319   45 SPDGARLAAGAGDLTLLLLDAAAGALLATL-LGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTG---- 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 133 lvfHQRRVGLVLWHPSAlNVLLTAGSDNQVVIWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTA 212
Cdd:COG2319  119 ---HTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194


                 ..
gi 442622557 213 EL 214
Cdd:COG2319  195 KL 196
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 349-391 1.98e-18

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 78.71  E-value: 1.98e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 442622557  349 CQVISMTVPRKS-DLFQEDLYPDTLAEDAAITAEEWIDGKDADP 391
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 85-208 9.41e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.84  E-value: 9.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557  85 GHKGPVLDIAWCPhNDNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvdlvfHQRRVGLVLWHPSalNVLLTAGSDNQVV- 163
Cdd:cd00200  175 GHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-------HENGVNSVAFSPD--GYLLASGSEDGTIr 244

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 442622557 164 IWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYD 208
Cdd:cd00200  245 VWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
71-224 7.10e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.33  E-value: 7.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557  71 WQVGRIAADHPLVGGHKGPVLDIAWCPhNDNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvdlvfHQRRVGLVLWHPSAl 150
Cdd:COG2319   20 LLAAALGALLLLLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGALLATLLG-------HTAAVLSVAFSPDG- 90

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442622557 151 NVLLTAGSDNQVVIWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGS 224
Cdd:COG2319   91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA 164
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 93-190 3.69e-07

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 48.04  E-value: 3.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557   93 IAWCPHNDnVIASGSEDCVV--------KVWQIPDGGLSRTLTEpvvdlvfhqrrvglVLWHPSAlNVLLTAGSDNQVVI 164
Cdd:pfam12894   1 MSWCPTMD-LIALATEDGELllhrlnwqRVWTLSPDKEDLEVTS--------------LAWRPDG-KLLAVGYSDGTVRL 64

                          90       100
                  ....*....|....*....|....*.
gi 442622557  165 WNVGTGEILVHIDSHPDIVysACFNW 190
Cdd:pfam12894  65 LDAENGKIVHHFSAGSDLI--TCLGW 88
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-115 1.42e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.42e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 442622557    85 GHKGPVLDIAWCPhNDNVIASGSEDCVVKVW 115
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 169-208 1.20e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.20e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 442622557   169 TGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYD 208
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
85-115 2.84e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.84e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 442622557   85 GHKGPVLDIAWCPhNDNVIASGSEDCVVKVW 115
Cdd:pfam00400   9 GHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-244 5.56e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 5.56e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622557 175 HIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGSKATRAIFLRHGLIFTTGFNR 244
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDK 73
WD40 pfam00400
WD domain, G-beta repeat;
170-208 2.70e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.70e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442622557  170 GEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYD 208
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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