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Conserved domains on  [gi|442622629|ref|NP_001260753|]
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tetraspanin 42Ee, isoform B [Drosophila melanogaster]

Protein Classification

tetraspanin family protein( domain architecture ID 11992908)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0016020
PubMed:  15763890|11756464|19709882|16024509|32974937
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
8-217 1.39e-24

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 95.85  E-value: 1.39e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622629    8 VKYILFIFNTIVSVIGILGIVYGVLILKSIGVVEVNGQVGFPIqalMPIILISLGSIVVFISFLGCCGAIRESVCMTMSY 87
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAY---IPILLIVLGAVIFLVGFLGCCGALKENRCLLLTY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622629   88 ATFLLILLILQLTFVVLLFTHREEFENAMGNVIENA-------WNSEHTYKGGVFDTIQKSLHCCGsssaldyigkgdlv 160
Cdd:pfam00335  78 FVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSledgyrdWLDLYSCLNSALDSLQSEFGCCG-------------- 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 442622629  161 ppsccsgscliptnyypGCRGKFVELMTTGSDNAKYVGIGLIGIELIGFIFACCLAN 217
Cdd:pfam00335 144 -----------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
8-217 1.39e-24

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 95.85  E-value: 1.39e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622629    8 VKYILFIFNTIVSVIGILGIVYGVLILKSIGVVEVNGQVGFPIqalMPIILISLGSIVVFISFLGCCGAIRESVCMTMSY 87
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAY---IPILLIVLGAVIFLVGFLGCCGALKENRCLLLTY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622629   88 ATFLLILLILQLTFVVLLFTHREEFENAMGNVIENA-------WNSEHTYKGGVFDTIQKSLHCCGsssaldyigkgdlv 160
Cdd:pfam00335  78 FVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSledgyrdWLDLYSCLNSALDSLQSEFGCCG-------------- 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 442622629  161 ppsccsgscliptnyypGCRGKFVELMTTGSDNAKYVGIGLIGIELIGFIFACCLAN 217
Cdd:pfam00335 144 -----------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 106-187 5.34e-19

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 78.32  E-value: 5.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622629 106 FTHREEFENAMGNVIENAWNSEHTYKG--GVFDTIQKSLHCCGSSSALDYIGKGDLVPPSCCSGSCLIP--TNYYPGCRG 181
Cdd:cd03127    1 FVYRDQLESLVSDTLNDAWDEYYVDDDfqEAMDALQSTFECCGVNGPTDYLDLRLLVPSSCCKGTDGNCglNLYTEGCLE 80


                 ....*.
gi 442622629 182 KFVELM 187
Cdd:cd03127   81 KLVDFL 86
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
8-217 1.39e-24

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 95.85  E-value: 1.39e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622629    8 VKYILFIFNTIVSVIGILGIVYGVLILKSIGVVEVNGQVGFPIqalMPIILISLGSIVVFISFLGCCGAIRESVCMTMSY 87
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAY---IPILLIVLGAVIFLVGFLGCCGALKENRCLLLTY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622629   88 ATFLLILLILQLTFVVLLFTHREEFENAMGNVIENA-------WNSEHTYKGGVFDTIQKSLHCCGsssaldyigkgdlv 160
Cdd:pfam00335  78 FVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSledgyrdWLDLYSCLNSALDSLQSEFGCCG-------------- 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 442622629  161 ppsccsgscliptnyypGCRGKFVELMTTGSDNAKYVGIGLIGIELIGFIFACCLAN 217
Cdd:pfam00335 144 -----------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 106-187 5.34e-19

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 78.32  E-value: 5.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622629 106 FTHREEFENAMGNVIENAWNSEHTYKG--GVFDTIQKSLHCCGSSSALDYIGKGDLVPPSCCSGSCLIP--TNYYPGCRG 181
Cdd:cd03127    1 FVYRDQLESLVSDTLNDAWDEYYVDDDfqEAMDALQSTFECCGVNGPTDYLDLRLLVPSSCCKGTDGNCglNLYTEGCLE 80


                 ....*.
gi 442622629 182 KFVELM 187
Cdd:cd03127   81 KLVDFL 86
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 109-165 1.19e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 45.54  E-value: 1.19e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442622629 109 REEFENAMGNVIENAWNSEHTYKggVFDTIQKSLHCCGSSSALDYIGK----GDLVPPSCC 165
Cdd:cd03166    8 MSEFNDSFNQMISNYNKTNDFRK--ILDRMQKDLKCCGANNYTDWENIpsldTDSVPDSCC 66
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 120-180 9.59e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 40.04  E-value: 9.59e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442622629 120 IENAWnsehtykggvfDTIQKSLHCCGSSSALDY--IGKGDLVPPSCCSgscliptNYYPGCR 180
Cdd:cd03165   30 LTNAW-----------DITQTEFRCCGVTNYTDWyeVLGENRVPDSCCQ-------EDSQDCG 74
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 136-198 1.33e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 39.39  E-value: 1.33e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442622629 136 DTIQKSLHCCGSSSALDYIGkgdLVPPSCCSGSClipTNYYPGCrgkFVELMTTGSDNAKYVG 198
Cdd:cd03164   33 DMIQSNLQCCGINGTTDWGS---GVPSSCCSSDT---EYKVEGC---YKKLKNWFESNFLYTG 86
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 107-165 5.26e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 38.11  E-value: 5.26e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442622629 107 THREEFENAMGNVIENAWNSEhtykggVFDTIQKSLHCCGSSSALD------YIGKGdlVPPSCC 165
Cdd:cd03161   10 TFLRTYNEAVSNYNGDDERSD------AVDTVQRTLHCCGVENYTDwlnspyFLEKG--IPLSCC 66
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 106-165 9.42e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 37.75  E-value: 9.42e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442622629 106 FTHREEFENAMGNVIE--------NAWNS--EHTYkggvfDTIQKSLHCCGSSSALDYIGKG-------DLVPPSCC 165
Cdd:cd03160    2 YFQRDKLKQEMGDIVEkviqnyggNPENKtaEEAW-----DYVQFQLQCCGWTGPQDWTDNSliknssePLYPCSCC 73
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 135-193 1.32e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 37.33  E-value: 1.32e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442622629 135 FDTIQKSLHCCGSSSALDYIG---------KGDLVPPSCC-----SGSCL--IPTNYYPGCRGKFVELMTTGSDN 193
Cdd:cd03155   35 VDELQQEFKCCGSNNYTDWQDsewinsneaNGRLVPDSCCktvvdRCGCLrdHPSNIYKVEGGCIPKLEDFLYDH 109
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 109-187 1.52e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 37.02  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622629 109 REEFENAMGNViENAWNSEHTYKGGVfDTIQKSLHCCGSSSALDYIG-------KGDLVPPSC-------CSGSCLIPTN 174
Cdd:cd03163    9 EDELNPSIDKV-FNKYNGTNAESRAV-DYLQRQLQCCGIHNYTDWENtpwfkesKNNSVPLSCcketftsCTGSLTQPKD 86

                         90
                 ....*....|....
gi 442622629 175 YYP-GCRGKFVELM 187
Cdd:cd03163   87 LYQeGCEAKLVKKL 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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