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Conserved domains on  [gi|442623382|ref|NP_001260903|]
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megator, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR_MLP1_2 pfam07926
TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...
 1031-1158 6.22e-21

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of human TPR protein and to yeast myosin-like proteins 1 (MLP1) and 2 (MLP2). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments, and is implicated in nuclear protein import. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerization of kinase domains or by targeting these kinases to the nuclear pore complex. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity.


:

Pssm-ID: 462316 [Multi-domain]  Cd Length: 129  Bit Score: 90.78  E-value: 6.22e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1031 QLKSAQDDLKSLLEKLTEANCTIRTLRSENTSLVESLNAAEVKYANGMIQHSADIQELTRYKAEFFKANDELNQLKSGRE 1110
Cdd:pfam07926    2 ELSSLQSEIKRLKEEAADAEAQLQKLQEDLEKQAEIAREAQQNYERELVLHAEDIKALQALREELNELKAEIAELKAEAE 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 442623382  1111 SLQAAYDELLRSNAEAQKLLDKEREESEKRVADLHALNSNLHDQIEAL 1158
Cdd:pfam07926   82 SAKAELEESEESWEEQKKELEKELSELEKRIEDLNEQNKLLHDQLESL 129
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 837-1593 9.10e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.52  E-value: 9.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   837 QRLDDTVRELAAQRRHFQ---EEEEKFRE---------------SINEFKRQAETAIKLKDEEKQLADKWQAELTSVREE 898
Cdd:TIGR02168  189 DRLEDILNELERQLKSLErqaEKAERYKElkaelrelelallvlRLEELREELEELQEELKEAEEELEELTAELQELEEK 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   899 LAEKVNKVNELSKKLQEvLTPTLNdnpitAANKRAREFELKLDQATVEIESLTKELAKTREHGEQFYKMSQSAESEIKRL 978
Cdd:TIGR02168  269 LEELRLEVSELEEEIEE-LQKELY-----ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAEL 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   979 HELHGEL---VAKQEEEIKKLRSSEAELKTRISDLEAEamlsnVTEQSKTVNQ-SGQLKSAQDDLKSLLEKLTEANCTIR 1054
Cdd:TIGR02168  343 EEKLEELkeeLESLEAELEELEAELEELESRLEELEEQ-----LETLRSKVAQlELQIASLNNEIERLEARLERLEDRRE 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1055 TLRSENTSLVESLNAAEVKYANGMIqhSADIQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSNAEAQKLLD--- 1131
Cdd:TIGR02168  418 RLQQEIEELLKKLEEAELKELQAEL--EELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDsle 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1132 --KEREESEKRVADLHALNSNLHDQIEALASKL------------AVLASQSQNPNSSLNESAMDGDQSL--NASGLTA- 1194
Cdd:TIGR02168  496 rlQENLEGFSEGVKALLKNQSGLSGILGVLSELisvdegyeaaieAALGGRLQAVVVENLNAAKKAIAFLkqNELGRVTf 575

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1195 ---------AEEGRNNEQLLKIIKFLRKEKDLFAAKLDILKAENARLiSEHAIqqkkVDELNGYLNQERAKSQ------T 1259
Cdd:TIGR02168  576 lpldsikgtEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLL-GGVLV----VDDLDNALELAKKLRPgyrivtL 650

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1260 DVVSANKHEEVLRKIETLNAITDSNRI----LREERNALTLRVAELTDRISSVEKELFPLQCSNKELTSKIEEINVENTS 1335
Cdd:TIGR02168  651 DGDLVRPGGVITGGSAKTNSSILERRReieeLEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISA 730

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1336 LRTEAIKWRQRANALVEKSNRNPEEFKRLQAEREHLAKLLTAEKELNKKQSDELTVLKQRMNTeipmLNKQMQILDEARK 1415
Cdd:TIGR02168  731 LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQ----LKEELKALREALD 806

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1416 KQVDEFTNLKQNNTRQTQDIMELKNRLLQKEEELLKANEELETKDKTIAD----KETKELQLRKLAKRYKDFYIGLQSQG 1491
Cdd:TIGR02168  807 ELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESlaaeIEELEELIEELESELEALLNERASLE 886

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1492 GGTESA-AELEKVRSELEEVNNQLRALKDEHEKITKECDEVKKRTEpetdtsAIRQEYKAKLDKLVVDLTVARTDLVNQE 1570
Cdd:TIGR02168  887 EALALLrSELEELSEELRELESKRSELRRELEELREKLAQLELRLE------GLEVRIDNLQERLSEEYSLTLEEAEALE 960

                          810       820
                   ....*....|....*....|...
gi 442623382  1571 TTFAGTKSSYDETIARLEKELQE 1593
Cdd:TIGR02168  961 NKIEDDEEEARRRLKRLENKIKE 983
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 55-913 1.76e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 86.65  E-value: 1.76e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    55 QKKEELENKMEDYLVK-FTSFELNVNELRTHLDQMSSERVNLMDTIAKGEQTISQLRKEKASVVEERDSMMKVIERQQAE 133
Cdd:TIGR02168  217 ELKAELRELELALLVLrLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANE 296

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   134 LERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELKENRMESERDMLHKEILLISGDLNKSNAELQNIRREHTi 213
Cdd:TIGR02168  297 ISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLE- 375

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   214 ntmQLQSCLKEKTESLKLMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQATEEyvgkLKKELDAKEKlfeifkstesdhl 293
Cdd:TIGR02168  376 ---ELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEE----LLKKLEEAEL------------- 435

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   294 iqrEELLQGISEIKRLLEEAEEQCAQLTEQMETMKQkhsaELDEQNKKIQAMEQELASANDLLK--QARESNLESAICQL 371
Cdd:TIGR02168  436 ---KELQAELEELEEELEELQEELERLEEALEELRE----ELEEAEQALDAAERELAQLQARLDslERLQENLEGFSEGV 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   372 APSAAVASRLIRSDLSLTELYSMYAKSSEELEmrnceiEQLKLQLKSIIAEISESApileKQNSDYQKMKETNSELLREH 451
Cdd:TIGR02168  509 KALLKNQSGLSGILGVLSELISVDEGYEAAIE------AALGGRLQAVVVENLNAA----KKAIAFLKQNELGRVTFLPL 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   452 DELLQNKLclERELERALSTLNHNQNENKKLKQTHTDLSRQVCMLLDELNCIRAGVKHVRIQptRQLPTSESLISDN--- 528
Cdd:TIGR02168  579 DSIKGTEI--QGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELA--KKLRPGYRIVTLDgdl 654

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   529 -----LVTFSSieelVDRNTYLLNMSRELTELLEASEKNQDKmlLEQSKNHIRKLDARFAELEDLLTQKNNTVTTLLSKC 603
Cdd:TIGR02168  655 vrpggVITGGS----AKTNSSILERRREIEELEEKIEELEEK--IAELEKALAELRKELEELEEELEQLRKELEELSRQI 728

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   604 DRYKKLYFAAQKKLGQNTVDLDDSNLEPNDsALDTSEQPAANFEESRKLEKRVRQLEQQLEGEVKKYASLKENYDYYTSE 683
Cdd:TIGR02168  729 SALRKDLARLEAEVEQLEERIAQLSKELTE-LEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDE 807

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   684 KRK-----NDALAQEQF--DSMRKEVRELTSSNCKLMNTTEFQKEQIELLHKNIGTYKQQVTTLEERTKNYEKTIIKHEQ 756
Cdd:TIGR02168  808 LRAeltllNEEAANLRErlESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEE 887

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   757 TVHLLKDEMmaahrkhAAADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQSLLLNSLEFIKTNLERSEMEGRQRLE 836
Cdd:TIGR02168  888 ALALLRSEL-------EELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALE 960

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   837 QRLDDTVRELAAQRRHFQEEEEKF----RESINEFKRQAEtaiKLKDEEKQLADkwqaeLTSVREELAEKVNKVNELSKK 912
Cdd:TIGR02168  961 NKIEDDEEEARRRLKRLENKIKELgpvnLAAIEEYEELKE---RYDFLTAQKED-----LTEAKETLEEAIEEIDREARE 1032


                   .
gi 442623382   913 L 913
Cdd:TIGR02168 1033 R 1033
PHA03169 super family cl27451
hypothetical protein; Provisional
 2117-2267 8.68e-06

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PHA03169:

Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 50.74  E-value: 8.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2117 ESAEVDGTAEVAGGAPHESAGPSDTGA----ASASSPQK---QSEAGESSGSDALKAADDGGDHADGTDNAREADEAFAE 2189
Cdd:PHA03169   84 KEERGQGGPSGSGSESVGSPTPSPSGSaeelASGLSPENtsgSSPESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQP 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2190 ETMATGQGEDsqplGNDNPNVGTSQSEVSHNQANLGEgNPTEDSEGADGVSSEGEKQAVGVEE--EGREAEATS----PS 2263
Cdd:PHA03169  164 SSFLQPSHED----SPEEPEPPTSEPEPDSPGPPQSE-TPTSSPPPQSPPDEPGEPQSPTPQQapSPNTQQAVEhedePT 238


                  ....
gi 442623382 2264 ENTR 2267
Cdd:PHA03169  239 EPER 242
MSCRAMM_ClfA super family cl41352
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 1937-2240 1.54e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


The actual alignment was detected with superfamily member NF033609:

Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 43.74  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1937 DSGMDVDQMPTSSQRDQEDDIQVVDSDDEEDVLADADDGPIDGGEAEQEGYEDS-YEQDNEMDDNEGGDDDNDIAVDAQD 2015
Cdd:NF033609  605 DSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDS 684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2016 NNEVDIEVPEQHMQAQEESQSLDNQAIATASASTQENNQSQAITSGSGESSNPVTLPQAEASNWKQAAASTSTAAARRNE 2095
Cdd:NF033609  685 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 764

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2096 SSVEIVSSPQVSNFCEQPARLESAEVDGTAEVAGGAPHESAGPSDTGAASASSPQKQSEAGESSGSDALKAADDGGDHAD 2175
Cdd:NF033609  765 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 844

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442623382 2176 GTDNAREAD-EAFAEETMATGQGEDSQPLGNDNPNVGTSQSevSHNQA-NLGEGNPTEDSEGADGVS 2240
Cdd:NF033609  845 DSDSDSDSDsDSESDSNSDSESGSNNNVVPPNSPKNGTNAS--NKNEAkDSKEPLPDTGSEDEANTS 909
 
Name Accession Description Interval E-value
TPR_MLP1_2 pfam07926
TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...
 1031-1158 6.22e-21

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of human TPR protein and to yeast myosin-like proteins 1 (MLP1) and 2 (MLP2). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments, and is implicated in nuclear protein import. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerization of kinase domains or by targeting these kinases to the nuclear pore complex. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity.


Pssm-ID: 462316 [Multi-domain]  Cd Length: 129  Bit Score: 90.78  E-value: 6.22e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1031 QLKSAQDDLKSLLEKLTEANCTIRTLRSENTSLVESLNAAEVKYANGMIQHSADIQELTRYKAEFFKANDELNQLKSGRE 1110
Cdd:pfam07926    2 ELSSLQSEIKRLKEEAADAEAQLQKLQEDLEKQAEIAREAQQNYERELVLHAEDIKALQALREELNELKAEIAELKAEAE 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 442623382  1111 SLQAAYDELLRSNAEAQKLLDKEREESEKRVADLHALNSNLHDQIEAL 1158
Cdd:pfam07926   82 SAKAELEESEESWEEQKKELEKELSELEKRIEDLNEQNKLLHDQLESL 129
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 837-1593 9.10e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.52  E-value: 9.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   837 QRLDDTVRELAAQRRHFQ---EEEEKFRE---------------SINEFKRQAETAIKLKDEEKQLADKWQAELTSVREE 898
Cdd:TIGR02168  189 DRLEDILNELERQLKSLErqaEKAERYKElkaelrelelallvlRLEELREELEELQEELKEAEEELEELTAELQELEEK 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   899 LAEKVNKVNELSKKLQEvLTPTLNdnpitAANKRAREFELKLDQATVEIESLTKELAKTREHGEQFYKMSQSAESEIKRL 978
Cdd:TIGR02168  269 LEELRLEVSELEEEIEE-LQKELY-----ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAEL 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   979 HELHGEL---VAKQEEEIKKLRSSEAELKTRISDLEAEamlsnVTEQSKTVNQ-SGQLKSAQDDLKSLLEKLTEANCTIR 1054
Cdd:TIGR02168  343 EEKLEELkeeLESLEAELEELEAELEELESRLEELEEQ-----LETLRSKVAQlELQIASLNNEIERLEARLERLEDRRE 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1055 TLRSENTSLVESLNAAEVKYANGMIqhSADIQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSNAEAQKLLD--- 1131
Cdd:TIGR02168  418 RLQQEIEELLKKLEEAELKELQAEL--EELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDsle 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1132 --KEREESEKRVADLHALNSNLHDQIEALASKL------------AVLASQSQNPNSSLNESAMDGDQSL--NASGLTA- 1194
Cdd:TIGR02168  496 rlQENLEGFSEGVKALLKNQSGLSGILGVLSELisvdegyeaaieAALGGRLQAVVVENLNAAKKAIAFLkqNELGRVTf 575

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1195 ---------AEEGRNNEQLLKIIKFLRKEKDLFAAKLDILKAENARLiSEHAIqqkkVDELNGYLNQERAKSQ------T 1259
Cdd:TIGR02168  576 lpldsikgtEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLL-GGVLV----VDDLDNALELAKKLRPgyrivtL 650

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1260 DVVSANKHEEVLRKIETLNAITDSNRI----LREERNALTLRVAELTDRISSVEKELFPLQCSNKELTSKIEEINVENTS 1335
Cdd:TIGR02168  651 DGDLVRPGGVITGGSAKTNSSILERRReieeLEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISA 730

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1336 LRTEAIKWRQRANALVEKSNRNPEEFKRLQAEREHLAKLLTAEKELNKKQSDELTVLKQRMNTeipmLNKQMQILDEARK 1415
Cdd:TIGR02168  731 LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQ----LKEELKALREALD 806

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1416 KQVDEFTNLKQNNTRQTQDIMELKNRLLQKEEELLKANEELETKDKTIAD----KETKELQLRKLAKRYKDFYIGLQSQG 1491
Cdd:TIGR02168  807 ELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESlaaeIEELEELIEELESELEALLNERASLE 886

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1492 GGTESA-AELEKVRSELEEVNNQLRALKDEHEKITKECDEVKKRTEpetdtsAIRQEYKAKLDKLVVDLTVARTDLVNQE 1570
Cdd:TIGR02168  887 EALALLrSELEELSEELRELESKRSELRRELEELREKLAQLELRLE------GLEVRIDNLQERLSEEYSLTLEEAEALE 960

                          810       820
                   ....*....|....*....|...
gi 442623382  1571 TTFAGTKSSYDETIARLEKELQE 1593
Cdd:TIGR02168  961 NKIEDDEEEARRRLKRLENKIKE 983
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 55-913 1.76e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 86.65  E-value: 1.76e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    55 QKKEELENKMEDYLVK-FTSFELNVNELRTHLDQMSSERVNLMDTIAKGEQTISQLRKEKASVVEERDSMMKVIERQQAE 133
Cdd:TIGR02168  217 ELKAELRELELALLVLrLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANE 296

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   134 LERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELKENRMESERDMLHKEILLISGDLNKSNAELQNIRREHTi 213
Cdd:TIGR02168  297 ISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLE- 375

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   214 ntmQLQSCLKEKTESLKLMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQATEEyvgkLKKELDAKEKlfeifkstesdhl 293
Cdd:TIGR02168  376 ---ELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEE----LLKKLEEAEL------------- 435

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   294 iqrEELLQGISEIKRLLEEAEEQCAQLTEQMETMKQkhsaELDEQNKKIQAMEQELASANDLLK--QARESNLESAICQL 371
Cdd:TIGR02168  436 ---KELQAELEELEEELEELQEELERLEEALEELRE----ELEEAEQALDAAERELAQLQARLDslERLQENLEGFSEGV 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   372 APSAAVASRLIRSDLSLTELYSMYAKSSEELEmrnceiEQLKLQLKSIIAEISESApileKQNSDYQKMKETNSELLREH 451
Cdd:TIGR02168  509 KALLKNQSGLSGILGVLSELISVDEGYEAAIE------AALGGRLQAVVVENLNAA----KKAIAFLKQNELGRVTFLPL 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   452 DELLQNKLclERELERALSTLNHNQNENKKLKQTHTDLSRQVCMLLDELNCIRAGVKHVRIQptRQLPTSESLISDN--- 528
Cdd:TIGR02168  579 DSIKGTEI--QGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELA--KKLRPGYRIVTLDgdl 654

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   529 -----LVTFSSieelVDRNTYLLNMSRELTELLEASEKNQDKmlLEQSKNHIRKLDARFAELEDLLTQKNNTVTTLLSKC 603
Cdd:TIGR02168  655 vrpggVITGGS----AKTNSSILERRREIEELEEKIEELEEK--IAELEKALAELRKELEELEEELEQLRKELEELSRQI 728

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   604 DRYKKLYFAAQKKLGQNTVDLDDSNLEPNDsALDTSEQPAANFEESRKLEKRVRQLEQQLEGEVKKYASLKENYDYYTSE 683
Cdd:TIGR02168  729 SALRKDLARLEAEVEQLEERIAQLSKELTE-LEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDE 807

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   684 KRK-----NDALAQEQF--DSMRKEVRELTSSNCKLMNTTEFQKEQIELLHKNIGTYKQQVTTLEERTKNYEKTIIKHEQ 756
Cdd:TIGR02168  808 LRAeltllNEEAANLRErlESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEE 887

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   757 TVHLLKDEMmaahrkhAAADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQSLLLNSLEFIKTNLERSEMEGRQRLE 836
Cdd:TIGR02168  888 ALALLRSEL-------EELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALE 960

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   837 QRLDDTVRELAAQRRHFQEEEEKF----RESINEFKRQAEtaiKLKDEEKQLADkwqaeLTSVREELAEKVNKVNELSKK 912
Cdd:TIGR02168  961 NKIEDDEEEARRRLKRLENKIKELgpvnLAAIEEYEELKE---RYDFLTAQKED-----LTEAKETLEEAIEEIDREARE 1032


                   .
gi 442623382   913 L 913
Cdd:TIGR02168 1033 R 1033
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 832-1420 1.27e-14

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 80.37  E-value: 1.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  832 RQRLEqRLDDTVRELAAQRRHFQEEeekfresinefKRQAETAIKLKDEEKQ-------LADKW-QAELTSVREELAEKV 903
Cdd:COG1196   185 EENLE-RLEDILGELERQLEPLERQ-----------AEKAERYRELKEELKEleaelllLKLRElEAELEELEAELEELE 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  904 NKVNELSKKLQEvltptlndnpitaANKRAREFELKLDQATVEIESLTKELaktREHGEQFYKMSQSAESEIKRLHELHG 983
Cdd:COG1196   253 AELEELEAELAE-------------LEAELEELRLELEELELELEEAQAEE---YELLAELARLEQDIARLEERRRELEE 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  984 ELvAKQEEEIKKLRSSEAELKTRISDLEAEAMLSNVTEQSKTVNQSGQLKSAQDDLKSLLEKLTEanctIRTLRSENTSL 1063
Cdd:COG1196   317 RL-EELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEE----LEELAEELLEA 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1064 VESLNAAEVKYANGMIQHSADIQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSNAEAQKLLDKEREESEKRVAD 1143
Cdd:COG1196   392 LRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEE 471

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1144 LHALNSNLHDQIEALASKLAVLASQSQnpnsslnesaMDGDQSLNASGLTAAEEGRNNEQLLKIIKFLRkeKDLFAAKLD 1223
Cdd:COG1196   472 AALLEAALAELLEELAEAAARLLLLLE----------AEADYEGFLEGVKAALLLAGLRGLAGAVAVLI--GVEAAYEAA 539

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1224 ILKAENARLISEHAIQQKKVDELNGYLNQERAKSQT--------DVVSANKHEEVLRKIETLNAITDSNRILREERNALT 1295
Cdd:COG1196   540 LEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATflpldkirARAALAAALARGAIGAAVDLVASDLREADARYYVLG 619

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1296 LRVAELTDRISSVEKELFPLQCSNKELTSKIEEINVENTSLRTEAIKWRQRANALVEKSNRNPEEFKRLQAEREHLAKLL 1375
Cdd:COG1196   620 DTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEAL 699

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 442623382 1376 TAEKELNKKQSDELTVLKQRMNTEIPMLNKQMQILDEARKKQVDE 1420
Cdd:COG1196   700 LAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEE 744
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
972-1552 1.43e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 73.56  E-value: 1.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  972 ESEIKRLHELHGELVAKQEEeIKKLRSSEAELKTRISDLEAE--AMLSNVTEQSKTVNQsgqLKSAQDDLKSLLEKLTEA 1049
Cdd:PRK03918  161 ENAYKNLGEVIKEIKRRIER-LEKFIKRTENIEELIKEKEKEleEVLREINEISSELPE---LREELEKLEKEVKELEEL 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1050 NCTIRTLRSENTSLVESLNAAEvkyangmiqhsADIQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSNAEAQKL 1129
Cdd:PRK03918  237 KEEIEELEKELESLEGSKRKLE-----------EKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEY 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1130 LDKEREeSEKRVADLHALNSNLHDQIEALASKLAVLA------SQSQNPNSSLNESAMDGDQSL----NASGLTAAEEGR 1199
Cdd:PRK03918  306 LDELRE-IEKRLSRLEEEINGIEERIKELEEKEERLEelkkklKELEKRLEELEERHELYEEAKakkeELERLKKRLTGL 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1200 NNEQLLKIIKFLRKEKDLFAAKLDILKAENARLISEHAIQQKKVDELngylnqERAKSQTDVVSANKHEEvlRKIETLNA 1279
Cdd:PRK03918  385 TPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEEL------KKAKGKCPVCGRELTEE--HRKELLEE 456

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1280 ITDSNRILREERNALTLRVAELTDRISSVEK------ELFPLQCSN---KELTSKIEEINVENTSLRT-EAIKWRQRANA 1349
Cdd:PRK03918  457 YTAELKRIEKELKEIEEKERKLRKELRELEKvlkkesELIKLKELAeqlKELEEKLKKYNLEELEKKAeEYEKLKEKLIK 536

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1350 LVEKSNRNPEEFKRLQAEREHLAKLLTAEKELNKKQSDELTVLKQRMNTEIPMLNKQMQILDEARKkqvdEFTNLKQnnt 1429
Cdd:PRK03918  537 LKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYN----EYLELKD--- 609

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1430 rQTQDIMELKNRLLQKEEELLKANEELETKDKTIADKETKELQLRKL-----AKRYKDFYIGLQSQGGGTEsaAELEKVR 1504
Cdd:PRK03918  610 -AEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKyseeeYEELREEYLELSRELAGLR--AELEELE 686

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 442623382 1505 SELEEVNNQLRALKDEHEKITKECDEVKKRTEPETDTSAIRQ---EYKAKL 1552
Cdd:PRK03918  687 KRREEIKKTLEKLKEELEEREKAKKELEKLEKALERVEELREkvkKYKALL 737
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 103-367 2.53e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 66.11  E-value: 2.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  103 EQTISQLRKEKASVVEERDSMMKVIERQQAELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELKENRMESE 182
Cdd:COG1196   238 EAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEER 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  183 RDMLHKEILLISGDLNKSNAELQNIRREhtintmqlqscLKEKTESLKLMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQ 262
Cdd:COG1196   318 LEELEEELAELEEELEELEEELEELEEE-----------LEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  263 ATEEyvgKLKKELDAKEKLFEIfKSTESDHLIQREELLQGISEIKRLLEEAEEQCAQLTEQMETMKQKHSAELDEQNKKI 342
Cdd:COG1196   387 ELLE---ALRAAAELAAQLEEL-EEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALL 462

                         250       260
                  ....*....|....*....|....*
gi 442623382  343 QAMEQELASANDLLKQARESNLESA 367
Cdd:COG1196   463 ELLAELLEEAALLEAALAELLEELA 487
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 31-909 3.03e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 62.68  E-value: 3.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    31 EYINNFSDEYCKNRAaaNRLAEAEQKKEELENKM----EDYLVKFTSFELNVNELRTHLDQMSSERVNLMDTIAKGEQTI 106
Cdd:pfam02463  183 ENLAELIIDLEELKL--QELKLKEQAKKALEYYQlkekLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEI 260

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   107 SQLRKEKASVVEERDSMMKVIERQQAELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELKENRMESERDML 186
Cdd:pfam02463  261 EKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEEL 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   187 HKEILLISGDLNKSNAELQNIRREHTINTMQLQsclkEKTESLKLMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQATEE 266
Cdd:pfam02463  341 EKELKELEIKREAEEEEEEELEKLQEKLEQLEE----ELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQ 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   267 YVGKLKKELDAKEKLFEIFKStesdhliqREELLQGISEIKRLLEEAEEQCAQLTEQMETMKQKHSAELDEQNKKIQAME 346
Cdd:pfam02463  417 LEDLLKEEKKEELEILEEEEE--------SIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLEL 488

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   347 QELASANDLLKQARESNLESAICQLAPSAAVASRLIRSDLSLTELYSMYAKSSEELEMRNCEIEQLKlqLKSIIAEISES 426
Cdd:pfam02463  489 LLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSA--TADEVEERQKL 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   427 APILEKQNSDYQKmketnselLREHDELLQNKLCLERELERALSTLNHNQNENKKLKQTHTDLSRQVCMLLDELNCIRAG 506
Cdd:pfam02463  567 VRALTELPLGARK--------LRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLK 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   507 VKHVRIQPTRQLPTSESLISDNLVTFSSIEELVDRNTYLLNMSRELTELLEASEKNQDKMLLEQSKNHIRKLDARFAELE 586
Cdd:pfam02463  639 ESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLE 718

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   587 DLLtQKNNTVTTLLSKCDRYKKLYFAAQKKLGQNTVDLDDSNLEPNDSALDTSEQpaanfeESRKLEKRVRQLEQQLEGE 666
Cdd:pfam02463  719 AEE-LLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLK------EKELAEEREKTEKLKVEEE 791

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   667 VKKYASLKENydyytsEKRKNDALAQEQFDSMRKEVRELTSSNCKlmnttefQKEQIELLHKNIGTYKQQVTTLEERTKN 746
Cdd:pfam02463  792 KEEKLKAQEE------ELRALEEELKEEAELLEEEQLLIEQEEKI-------KEEELEELALELKEEQKLEKLAEEELER 858

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   747 YEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQSLLLNSLEFIKTNLER 826
Cdd:pfam02463  859 LEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPE 938

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   827 sEMEGRQRLEQRLDDTVRELAAQRRHFQEEEEKFRESIN-------EFKRQAETAIKLKDEEKQLADKWQAELTsvREEL 899
Cdd:pfam02463  939 -ELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNlmaieefEEKEERYNKDELEKERLEEEKKKLIRAI--IEET 1015

                          890
                   ....*....|
gi 442623382   900 AEKVNKVNEL 909
Cdd:pfam02463 1016 CQRLKEFLEL 1025
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 925-1177 1.35e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.39  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  925 PITAANKRAREFELKLDQATVEIESLTKELAKTREHGEQFYKMSQSAESEIKRLHelhgELVAKQEEEIKKLRSSEAELK 1004
Cdd:COG4942    14 AAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALA----RRIRALEQELAALEAELAELE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1005 TRISDLEAEamLSNVTEQSKTVNQSGQLKSAQDDLKSLLEKlTEANCTIRTLRsentsLVESLNAAEVKYANGMiqhSAD 1084
Cdd:COG4942    90 KEIAELRAE--LEAQKEELAELLRALYRLGRQPPLALLLSP-EDFLDAVRRLQ-----YLKYLAPARREQAEEL---RAD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1085 IQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSNAEAQKLLDKEREESEKRVADLHALNSNLHDQIEALASKLAV 1164
Cdd:COG4942   159 LAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238

                         250
                  ....*....|...
gi 442623382 1165 LASQSQNPNSSLN 1177
Cdd:COG4942   239 AAERTPAAGFAAL 251
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 820-1613 1.52e-08

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 60.37  E-value: 1.52e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   820 IKTNLERSEMEGRQRLEQRLDDTVRELAAQRRHFQEEEEKFRESINEFKRQAETAIKLKDEEKQLADKWQAELTSVREEL 899
Cdd:pfam02463  170 KKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDE 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   900 AEKVNKVNELSKKLQEVLTPTLNDNPITAANKRAREFELKLDQATVEIESLTKELAKTR-EHGEQFYKMSQSAESEIKRL 978
Cdd:pfam02463  250 QEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRkVDDEEKLKESEKEKKKAEKE 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   979 HELHGELVAKQEEEIKKLRSSEAELKTRISDLEAEAMLSNVTEQSKTVNQSGQLKSAQDDLKSLLEKLTEANCTIRTLRS 1058
Cdd:pfam02463  330 LKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQL 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1059 ENTSLVESLNAAevkyangmiqhsadiQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSnAEAQKLLDKEREESE 1138
Cdd:pfam02463  410 LLELARQLEDLL---------------KEEKKEELEILEEEEESIELKQGKLTEEKEELEKQEL-KLLKDELELKKSEDL 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1139 KRVADLHALNSNLHDQIEALASKLAVLASQSQNPNSSLNESAMDGDQSLNASGltaaEEGRNNEQLLKIIKFLRKEKDLF 1218
Cdd:pfam02463  474 LKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIIS----AHGRLGDLGVAVENYKVAISTAV 549

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1219 AAKLDILKAEnarlISEHAIQQKKVDELNGYLNQERAKSQTDVVSANKHEEVLRKIETLNAITDSNRILREERNALTLRV 1298
Cdd:pfam02463  550 IVEVSATADE----VEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVV 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1299 ---AELTDRISSVEKELFPLQCSNKELTSKIEEINVENTSLRTEAIKWRQRANALVEKSNRNPEEFKRLQAEREHLAKLL 1375
Cdd:pfam02463  626 egiLKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKE 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1376 TAEKELNKKQSDELTVLKQRMNTEIpmLNKQMQILDEARKKQVDEFTNLKQNNTRQTQDIMELKNRLLQKEEELLKANEE 1455
Cdd:pfam02463  706 QREKEELKKLKLEAEELLADRVQEA--QDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKT 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1456 LETKDKTIADKETKELQLRKLAKRYKDFYIGLQSQGGGTESAAELEKVRSELEEVNNQLRALKDEHEKITKECDEVKKRT 1535
Cdd:pfam02463  784 EKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEI 863

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442623382  1536 EPETDTSAIRQEYKAKLDKLVVDLTVARTDLVNQETTFAGTKSSYDETIARLEKELQENIAANKDINQRLTRENESLH 1613
Cdd:pfam02463  864 TKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELL 941
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
23-493 1.90e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 56.61  E-value: 1.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   23 EDVQKKLSEYINNFSDEYCKNRAAANRLAEAEQKKEELENKMEDYLVKFTSFELNVNELRTHLDQMSSERVNLmdtiakg 102
Cdd:PRK03918  213 SSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKEL------- 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  103 eQTISQLRKEKASVVEERDSMMKVIERQQAELERLKQDLHTYQQQLSSAIAAKceaiARVDEIQSKEVALELKENRMEsE 182
Cdd:PRK03918  286 -KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKE----ERLEELKKKLKELEKRLEELE-E 359

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  183 RDMLHKEILLISGDLNKSNAELQNIRREHTINtmQLQSCLKEKTEslklMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQ 262
Cdd:PRK03918  360 RHELYEEAKAKKEELERLKKRLTGLTPEKLEK--ELEELEKAKEE----IEEEISKITARIGELKKEIKELKKAIEELKK 433

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  263 A-----------TEEYVGKL--------------KKELDAKE-KLFEIFKSTESDHLIQRE--ELLQGISEIKRLLEEAE 314
Cdd:PRK03918  434 AkgkcpvcgrelTEEHRKELleeytaelkriekeLKEIEEKErKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLK 513

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  315 EQCAQLTEQMETMKQKHSAELDEQNKKIQAMEQELASANDLLKQAREsnLESAICQLAPSAAVASRLIRS---------D 385
Cdd:PRK03918  514 KYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAE--LEKKLDELEEELAELLKELEElgfesveelE 591

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  386 LSLTELYSMYAK------SSEELEMRNCEIEQLKLQLKSIIAEISESAPILEKQNSDYQKMKETNSEllREHDELLQNKL 459
Cdd:PRK03918  592 ERLKELEPFYNEylelkdAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSE--EEYEELREEYL 669

                         490       500       510
                  ....*....|....*....|....*....|....
gi 442623382  460 CLERELERALSTLNHNQNENKKLKQTHTDLSRQV 493
Cdd:PRK03918  670 ELSRELAGLRAELEELEKRREEIKKTLEKLKEEL 703
PHA03169 PHA03169
hypothetical protein; Provisional
 2117-2267 8.68e-06

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 50.74  E-value: 8.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2117 ESAEVDGTAEVAGGAPHESAGPSDTGA----ASASSPQK---QSEAGESSGSDALKAADDGGDHADGTDNAREADEAFAE 2189
Cdd:PHA03169   84 KEERGQGGPSGSGSESVGSPTPSPSGSaeelASGLSPENtsgSSPESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQP 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2190 ETMATGQGEDsqplGNDNPNVGTSQSEVSHNQANLGEgNPTEDSEGADGVSSEGEKQAVGVEE--EGREAEATS----PS 2263
Cdd:PHA03169  164 SSFLQPSHED----SPEEPEPPTSEPEPDSPGPPQSE-TPTSSPPPQSPPDEPGEPQSPTPQQapSPNTQQAVEhedePT 238


                  ....
gi 442623382 2264 ENTR 2267
Cdd:PHA03169  239 EPER 242
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 1937-2240 1.54e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 43.74  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1937 DSGMDVDQMPTSSQRDQEDDIQVVDSDDEEDVLADADDGPIDGGEAEQEGYEDS-YEQDNEMDDNEGGDDDNDIAVDAQD 2015
Cdd:NF033609  605 DSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDS 684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2016 NNEVDIEVPEQHMQAQEESQSLDNQAIATASASTQENNQSQAITSGSGESSNPVTLPQAEASNWKQAAASTSTAAARRNE 2095
Cdd:NF033609  685 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 764

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2096 SSVEIVSSPQVSNFCEQPARLESAEVDGTAEVAGGAPHESAGPSDTGAASASSPQKQSEAGESSGSDALKAADDGGDHAD 2175
Cdd:NF033609  765 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 844

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442623382 2176 GTDNAREAD-EAFAEETMATGQGEDSQPLGNDNPNVGTSQSevSHNQA-NLGEGNPTEDSEGADGVS 2240
Cdd:NF033609  845 DSDSDSDSDsDSESDSNSDSESGSNNNVVPPNSPKNGTNAS--NKNEAkDSKEPLPDTGSEDEANTS 909
 
Name Accession Description Interval E-value
TPR_MLP1_2 pfam07926
TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...
 1031-1158 6.22e-21

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of human TPR protein and to yeast myosin-like proteins 1 (MLP1) and 2 (MLP2). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments, and is implicated in nuclear protein import. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerization of kinase domains or by targeting these kinases to the nuclear pore complex. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity.


Pssm-ID: 462316 [Multi-domain]  Cd Length: 129  Bit Score: 90.78  E-value: 6.22e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1031 QLKSAQDDLKSLLEKLTEANCTIRTLRSENTSLVESLNAAEVKYANGMIQHSADIQELTRYKAEFFKANDELNQLKSGRE 1110
Cdd:pfam07926    2 ELSSLQSEIKRLKEEAADAEAQLQKLQEDLEKQAEIAREAQQNYERELVLHAEDIKALQALREELNELKAEIAELKAEAE 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 442623382  1111 SLQAAYDELLRSNAEAQKLLDKEREESEKRVADLHALNSNLHDQIEAL 1158
Cdd:pfam07926   82 SAKAELEESEESWEEQKKELEKELSELEKRIEDLNEQNKLLHDQLESL 129
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 837-1593 9.10e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.52  E-value: 9.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   837 QRLDDTVRELAAQRRHFQ---EEEEKFRE---------------SINEFKRQAETAIKLKDEEKQLADKWQAELTSVREE 898
Cdd:TIGR02168  189 DRLEDILNELERQLKSLErqaEKAERYKElkaelrelelallvlRLEELREELEELQEELKEAEEELEELTAELQELEEK 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   899 LAEKVNKVNELSKKLQEvLTPTLNdnpitAANKRAREFELKLDQATVEIESLTKELAKTREHGEQFYKMSQSAESEIKRL 978
Cdd:TIGR02168  269 LEELRLEVSELEEEIEE-LQKELY-----ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAEL 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   979 HELHGEL---VAKQEEEIKKLRSSEAELKTRISDLEAEamlsnVTEQSKTVNQ-SGQLKSAQDDLKSLLEKLTEANCTIR 1054
Cdd:TIGR02168  343 EEKLEELkeeLESLEAELEELEAELEELESRLEELEEQ-----LETLRSKVAQlELQIASLNNEIERLEARLERLEDRRE 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1055 TLRSENTSLVESLNAAEVKYANGMIqhSADIQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSNAEAQKLLD--- 1131
Cdd:TIGR02168  418 RLQQEIEELLKKLEEAELKELQAEL--EELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDsle 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1132 --KEREESEKRVADLHALNSNLHDQIEALASKL------------AVLASQSQNPNSSLNESAMDGDQSL--NASGLTA- 1194
Cdd:TIGR02168  496 rlQENLEGFSEGVKALLKNQSGLSGILGVLSELisvdegyeaaieAALGGRLQAVVVENLNAAKKAIAFLkqNELGRVTf 575

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1195 ---------AEEGRNNEQLLKIIKFLRKEKDLFAAKLDILKAENARLiSEHAIqqkkVDELNGYLNQERAKSQ------T 1259
Cdd:TIGR02168  576 lpldsikgtEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLL-GGVLV----VDDLDNALELAKKLRPgyrivtL 650

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1260 DVVSANKHEEVLRKIETLNAITDSNRI----LREERNALTLRVAELTDRISSVEKELFPLQCSNKELTSKIEEINVENTS 1335
Cdd:TIGR02168  651 DGDLVRPGGVITGGSAKTNSSILERRReieeLEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISA 730

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1336 LRTEAIKWRQRANALVEKSNRNPEEFKRLQAEREHLAKLLTAEKELNKKQSDELTVLKQRMNTeipmLNKQMQILDEARK 1415
Cdd:TIGR02168  731 LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQ----LKEELKALREALD 806

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1416 KQVDEFTNLKQNNTRQTQDIMELKNRLLQKEEELLKANEELETKDKTIAD----KETKELQLRKLAKRYKDFYIGLQSQG 1491
Cdd:TIGR02168  807 ELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESlaaeIEELEELIEELESELEALLNERASLE 886

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1492 GGTESA-AELEKVRSELEEVNNQLRALKDEHEKITKECDEVKKRTEpetdtsAIRQEYKAKLDKLVVDLTVARTDLVNQE 1570
Cdd:TIGR02168  887 EALALLrSELEELSEELRELESKRSELRRELEELREKLAQLELRLE------GLEVRIDNLQERLSEEYSLTLEEAEALE 960

                          810       820
                   ....*....|....*....|...
gi 442623382  1571 TTFAGTKSSYDETIARLEKELQE 1593
Cdd:TIGR02168  961 NKIEDDEEEARRRLKRLENKIKE 983
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 55-913 1.76e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 86.65  E-value: 1.76e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    55 QKKEELENKMEDYLVK-FTSFELNVNELRTHLDQMSSERVNLMDTIAKGEQTISQLRKEKASVVEERDSMMKVIERQQAE 133
Cdd:TIGR02168  217 ELKAELRELELALLVLrLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANE 296

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   134 LERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELKENRMESERDMLHKEILLISGDLNKSNAELQNIRREHTi 213
Cdd:TIGR02168  297 ISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLE- 375

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   214 ntmQLQSCLKEKTESLKLMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQATEEyvgkLKKELDAKEKlfeifkstesdhl 293
Cdd:TIGR02168  376 ---ELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEE----LLKKLEEAEL------------- 435

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   294 iqrEELLQGISEIKRLLEEAEEQCAQLTEQMETMKQkhsaELDEQNKKIQAMEQELASANDLLK--QARESNLESAICQL 371
Cdd:TIGR02168  436 ---KELQAELEELEEELEELQEELERLEEALEELRE----ELEEAEQALDAAERELAQLQARLDslERLQENLEGFSEGV 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   372 APSAAVASRLIRSDLSLTELYSMYAKSSEELEmrnceiEQLKLQLKSIIAEISESApileKQNSDYQKMKETNSELLREH 451
Cdd:TIGR02168  509 KALLKNQSGLSGILGVLSELISVDEGYEAAIE------AALGGRLQAVVVENLNAA----KKAIAFLKQNELGRVTFLPL 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   452 DELLQNKLclERELERALSTLNHNQNENKKLKQTHTDLSRQVCMLLDELNCIRAGVKHVRIQptRQLPTSESLISDN--- 528
Cdd:TIGR02168  579 DSIKGTEI--QGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELA--KKLRPGYRIVTLDgdl 654

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   529 -----LVTFSSieelVDRNTYLLNMSRELTELLEASEKNQDKmlLEQSKNHIRKLDARFAELEDLLTQKNNTVTTLLSKC 603
Cdd:TIGR02168  655 vrpggVITGGS----AKTNSSILERRREIEELEEKIEELEEK--IAELEKALAELRKELEELEEELEQLRKELEELSRQI 728

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   604 DRYKKLYFAAQKKLGQNTVDLDDSNLEPNDsALDTSEQPAANFEESRKLEKRVRQLEQQLEGEVKKYASLKENYDYYTSE 683
Cdd:TIGR02168  729 SALRKDLARLEAEVEQLEERIAQLSKELTE-LEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDE 807

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   684 KRK-----NDALAQEQF--DSMRKEVRELTSSNCKLMNTTEFQKEQIELLHKNIGTYKQQVTTLEERTKNYEKTIIKHEQ 756
Cdd:TIGR02168  808 LRAeltllNEEAANLRErlESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEE 887

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   757 TVHLLKDEMmaahrkhAAADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQSLLLNSLEFIKTNLERSEMEGRQRLE 836
Cdd:TIGR02168  888 ALALLRSEL-------EELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALE 960

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   837 QRLDDTVRELAAQRRHFQEEEEKF----RESINEFKRQAEtaiKLKDEEKQLADkwqaeLTSVREELAEKVNKVNELSKK 912
Cdd:TIGR02168  961 NKIEDDEEEARRRLKRLENKIKELgpvnLAAIEEYEELKE---RYDFLTAQKED-----LTEAKETLEEAIEEIDREARE 1032


                   .
gi 442623382   913 L 913
Cdd:TIGR02168 1033 R 1033
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 720-1555 5.10e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 81.65  E-value: 5.10e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   720 KEQIELLHKNIGTYKQQVTTLE------ERTKNYEKTIIKHEQTVHLLKDEmmAAHRKHAAADAEAQSLRQEnrILRDTS 793
Cdd:TIGR02169  183 EENIERLDLIIDEKRQQLERLRrerekaERYQALLKEKREYEGYELLKEKE--ALERQKEAIERQLASLEEE--LEKLTE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   794 SRLQIEKETYHREQ-------QSQSLLLNSLEFIKTNLE--RSEMEGRQRLEQRLDDTVRELAAQRRHFQEEEEKFRESI 864
Cdd:TIGR02169  259 EISELEKRLEEIEQlleelnkKIKDLGEEEQLRVKEKIGelEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEI 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   865 NEFKRQAEtaiklkdEEKQLADKWQAELTSVREELAEKVNKVNELSKKLQEvltptlndnpitaANKRAREFELKLDQAT 944
Cdd:TIGR02169  339 EELEREIE-------EERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAE-------------TRDELKDYREKLEKLK 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   945 VEIESLTKELAKTREHGEQFYKMSQSAESEIKRLHELHGELVAKQEEEIKKLRSSEAELKTRISDLEaeamlsnvTEQSK 1024
Cdd:TIGR02169  399 REINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLS--------KYEQE 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1025 TVNQSGQLKSAQDDLKSLLEKLTEANCTIRTLRSENtslVESLNAAEVKYANGMIQHSAdIQELTRYKAEFFKAndeLNQ 1104
Cdd:TIGR02169  471 LYDLKEEYDRVEKELSKLQRELAEAEAQARASEERV---RGGRAVEEVLKASIQGVHGT-VAQLGSVGERYATA---IEV 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1105 LKSGResLQAAYDELLRSNAEAQKLLdKEREESE------KRVADLHALNSNLH---------------DQIE-----AL 1158
Cdd:TIGR02169  544 AAGNR--LNNVVVEDDAVAKEAIELL-KRRKAGRatflplNKMRDERRDLSILSedgvigfavdlvefdPKYEpafkyVF 620

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1159 ASKLAVLASQSQNP-NSSLNESAMDGDQSLNASGLTAAEEGRNNEQLLKiiKFLRKEKDLFAAKLDILKAENARLISEHA 1237
Cdd:TIGR02169  621 GDTLVVEDIEAARRlMGKYRMVTLEGELFEKSGAMTGGSRAPRGGILFS--RSEPAELQRLRERLEGLKRELSSLQSELR 698

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1238 IQQKKVDELNGYLnqERAKSQTDVVSaNKHEEVLRKIETLNA-ITDSNRIL----------REERNALTLRVAELTDRIS 1306
Cdd:TIGR02169  699 RIENRLDELSQEL--SDASRKIGEIE-KEIEQLEQEEEKLKErLEELEEDLssleqeienvKSELKELEARIEELEEDLH 775

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1307 SVEKELFPLQcsNKELTSKIEEINVENTSLRTEAIKWRQRANALVEKSNRNPEEFKRLQAEREHLAKL---LTAEKELNK 1383
Cdd:TIGR02169  776 KLEEALNDLE--ARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQridLKEQIKSIE 853

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1384 KQSDELTVLKQRMNTEIPMLNKQMQILDEARKkqvdeftNLKqnntrqtQDIMELKNRLLQKEEELLKANEELETKDKTI 1463
Cdd:TIGR02169  854 KEIENLNGKKEELEEELEELEAALRDLESRLG-------DLK-------KERDELEAQLRELERKIEELEAQIEKKRKRL 919

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1464 ADKETKELQLRKLAKRYKDFYIGLQSQGGGTESaaeLEKVRSELEEVNNQLRALKDEHEKITKECDEVKKRtepetdtsa 1543
Cdd:TIGR02169  920 SELKAKLEALEEELSEIEDPKGEDEEIPEEELS---LEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKR--------- 987

                          890
                   ....*....|..
gi 442623382  1544 iRQEYKAKLDKL 1555
Cdd:TIGR02169  988 -LDELKEKRAKL 998
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 128-1056 6.06e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 81.26  E-value: 6.06e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   128 ERQQAELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELKENRMESERDMLHKEILLISGDLNKSNAELQNI 207
Cdd:TIGR02168  221 ELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRL 300

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   208 RREhtintmqlqscLKEKTESLKLMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQATEEyvgkLKKELDAKEKLFEIFKS 287
Cdd:TIGR02168  301 EQQ-----------KQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEE----LKEELESLEAELEELEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   288 tesdhliQREELLQGISEIKRLLEEAEEQCAQLTEQMETmkqkhsaeldeQNKKIQAMEQELASANDLLKQARESNLEsa 367
Cdd:TIGR02168  366 -------ELEELESRLEELEEQLETLRSKVAQLELQIAS-----------LNNEIERLEARLERLEDRRERLQQEIEE-- 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   368 icqlapsaavasrlIRSDLSLTELysmyAKSSEELEMRNCEIEQLKLQLKSIIAEISESAPILEKQNSDYQKMKetnsel 447
Cdd:TIGR02168  426 --------------LLKKLEEAEL----KELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAE------ 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   448 lREHDELLQNKLCLERELERALStlnhNQNENKKLKQTHTDLSRQVCMLLDELNC---IRAGVKHVrIQPTRQLPTSESL 524
Cdd:TIGR02168  482 -RELAQLQARLDSLERLQENLEG----FSEGVKALLKNQSGLSGILGVLSELISVdegYEAAIEAA-LGGRLQAVVVENL 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   525 iSDNLVTFSSIEE-LVDRNTYL---LNMSRELTELLEASEKNQDKMLleQSKNHIRKLDARFAELEDLLTQKNNTVTTLL 600
Cdd:TIGR02168  556 -NAAKKAIAFLKQnELGRVTFLpldSIKGTEIQGNDREILKNIEGFL--GVAKDLVKFDPKLRKALSYLLGGVLVVDDLD 632

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   601 SKCDRYKKLYFaaqkklGQNTVDLDDSNLEPNDSALDTSEQPAANF----EESRKLEKRVRQLEQQLEgevkkyaslken 676
Cdd:TIGR02168  633 NALELAKKLRP------GYRIVTLDGDLVRPGGVITGGSAKTNSSIlerrREIEELEEKIEELEEKIA------------ 694

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   677 ydyytsEKRKNDALAQEQFDSMRKEVRELTSSNCKLMNTTEFQKEQIELLHKNIGTYKQQVTTLEERTKNYEKTIIKHEQ 756
Cdd:TIGR02168  695 ------ELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEE 768

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   757 TVHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQSLLLNSLEFiktnlersEMEGRQRLE 836
Cdd:TIGR02168  769 RLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLER--------RIAATERRL 840

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   837 QRLDDTVRELAAQRRHFQEEEEKFRESINEFKRQAETAIKLKDEEKQLADKWQAELTSVREELAEKVNKVNELSKKLQEv 916
Cdd:TIGR02168  841 EDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEE- 919

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   917 ltptlndnpitaANKRAREFELKLDQATVEIESLTKELAktrehgeqfykmsqsaeSEIKRLHELHGELVAKQEEEIKKL 996
Cdd:TIGR02168  920 ------------LREKLAQLELRLEGLEVRIDNLQERLS-----------------EEYSLTLEEAEALENKIEDDEEEA 970

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442623382   997 RSSEAELKTRIS-----DLEAEAMLSNVTEQSKTVNQsgQLKSAQDDLKSLLEKLTEANCTIRTL 1056
Cdd:TIGR02168  971 RRRLKRLENKIKelgpvNLAAIEEYEELKERYDFLTA--QKEDLTEAKETLEEAIEEIDREARER 1033
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 715-1457 1.10e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 80.49  E-value: 1.10e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   715 TTEFQKEQIELLHKNIGTYKQQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSS 794
Cdd:TIGR02168  212 AERYKELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELY 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   795 RLQIEKETYHREQQSQSlllNSLEFIKTNLERSEmEGRQRLEQRLDDTVRELAAQrrhfQEEEEKFRESINEFKRQAETA 874
Cdd:TIGR02168  292 ALANEISRLEQQKQILR---ERLANLERQLEELE-AQLEELESKLDELAEELAEL----EEKLEELKEELESLEAELEEL 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   875 IKLKDEEKQLADKWQAELTSVREELAEKVNKVNELSKKLQEvLTPTLNDNPITAANKRAREFELKLDQATVEIESLTKEL 954
Cdd:TIGR02168  364 EAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIER-LEARLERLEDRRERLQQEIEELLKKLEEAELKELQAEL 442

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   955 AKTREHGEQfykmSQSAESEIKRLHELHGELVAKQEEEIKKLRSSEAELKTRISDLEAeaMLSNVTEQSKTVNQSGQLKS 1034
Cdd:TIGR02168  443 EELEEELEE----LQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLER--LQENLEGFSEGVKALLKNQS 516

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1035 AQDDLKSLL---------------------------EKLTEANCTIRTLRSENTSLV----------ESLNAAEVKYANG 1077
Cdd:TIGR02168  517 GLSGILGVLselisvdegyeaaieaalggrlqavvvENLNAAKKAIAFLKQNELGRVtflpldsikgTEIQGNDREILKN 596

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1078 MIQHSADIQELTRYKAEFFKA--------------NDELNQLKS--GRESLQAAYDELLR--------SNAEAQKLL--D 1131
Cdd:TIGR02168  597 IEGFLGVAKDLVKFDPKLRKAlsyllggvlvvddlDNALELAKKlrPGYRIVTLDGDLVRpggvitggSAKTNSSILerR 676

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1132 KEREESEKRVADLHALNSNLHDQIEALASKLavlaSQSQNPNSSLNESAMDGDQSLNAsgltaaeegrnneqLLKIIKFL 1211
Cdd:TIGR02168  677 REIEELEEKIEELEEKIAELEKALAELRKEL----EELEEELEQLRKELEELSRQISA--------------LRKDLARL 738

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1212 RKEKDLFAAKLDILKAENARLISEHAIQQKKVDELNGYLNQERAKSQTDVVSANKHEEVLRKI-ETLNAITDSNRILREE 1290
Cdd:TIGR02168  739 EAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALrEALDELRAELTLLNEE 818

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1291 RNALTLRVAELTDRISSVEKELFPLQCSNKELTSKIEEINVENTSLRTEAIKWRQRANALVEKSNRNPEEFKRLQAEREH 1370
Cdd:TIGR02168  819 AANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEE 898

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1371 L-AKLLTAEKELNKKQsDELTVLKQRMNT----EIPMLNKQMQILDEARKKQVDEFTNLKQNNTRQTQDIMELKNRLLQK 1445
Cdd:TIGR02168  899 LsEELRELESKRSELR-RELEELREKLAQlelrLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRL 977

                          810
                   ....*....|....*....
gi 442623382  1446 EEEL-------LKANEELE 1457
Cdd:TIGR02168  978 ENKIkelgpvnLAAIEEYE 996
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 832-1420 1.27e-14

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 80.37  E-value: 1.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  832 RQRLEqRLDDTVRELAAQRRHFQEEeekfresinefKRQAETAIKLKDEEKQ-------LADKW-QAELTSVREELAEKV 903
Cdd:COG1196   185 EENLE-RLEDILGELERQLEPLERQ-----------AEKAERYRELKEELKEleaelllLKLRElEAELEELEAELEELE 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  904 NKVNELSKKLQEvltptlndnpitaANKRAREFELKLDQATVEIESLTKELaktREHGEQFYKMSQSAESEIKRLHELHG 983
Cdd:COG1196   253 AELEELEAELAE-------------LEAELEELRLELEELELELEEAQAEE---YELLAELARLEQDIARLEERRRELEE 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  984 ELvAKQEEEIKKLRSSEAELKTRISDLEAEAMLSNVTEQSKTVNQSGQLKSAQDDLKSLLEKLTEanctIRTLRSENTSL 1063
Cdd:COG1196   317 RL-EELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEE----LEELAEELLEA 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1064 VESLNAAEVKYANGMIQHSADIQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSNAEAQKLLDKEREESEKRVAD 1143
Cdd:COG1196   392 LRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEE 471

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1144 LHALNSNLHDQIEALASKLAVLASQSQnpnsslnesaMDGDQSLNASGLTAAEEGRNNEQLLKIIKFLRkeKDLFAAKLD 1223
Cdd:COG1196   472 AALLEAALAELLEELAEAAARLLLLLE----------AEADYEGFLEGVKAALLLAGLRGLAGAVAVLI--GVEAAYEAA 539

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1224 ILKAENARLISEHAIQQKKVDELNGYLNQERAKSQT--------DVVSANKHEEVLRKIETLNAITDSNRILREERNALT 1295
Cdd:COG1196   540 LEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATflpldkirARAALAAALARGAIGAAVDLVASDLREADARYYVLG 619

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1296 LRVAELTDRISSVEKELFPLQCSNKELTSKIEEINVENTSLRTEAIKWRQRANALVEKSNRNPEEFKRLQAEREHLAKLL 1375
Cdd:COG1196   620 DTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEAL 699

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 442623382 1376 TAEKELNKKQSDELTVLKQRMNTEIPMLNKQMQILDEARKKQVDE 1420
Cdd:COG1196   700 LAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEE 744
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 745-1305 5.82e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 74.97  E-value: 5.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  745 KNYEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSSRLQiekETYHREQQSQSLLLNSLefiktnl 824
Cdd:COG1196   235 RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQ---AEEYELLAELARLEQDI------- 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  825 eRSEMEGRQRLEQRLDDTVRELAAQRRHFQEEEEKFRESINEFKRQAETAIKLKDEEKQLADKWQAELTSVREELAEKVN 904
Cdd:COG1196   305 -ARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEE 383

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  905 KVNELSKKLQEVLTptlNDNPITAANKRAREFELKLDQATVEIESLTKELAKTREHGEQFYKMSQSAESEIKRLHELHGE 984
Cdd:COG1196   384 LAEELLEALRAAAE---LAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEA 460

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  985 LVAKQEEEIKKLRSSEAELKTRISDLEAEAMLSNVTEQSKTVNQSGQLKSAQDDLKSLLEKLTEANCTIRTLRSENTSLV 1064
Cdd:COG1196   461 LLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAAL 540

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1065 ESLNAAEVKYANGMIQHSAD--IQELTRYKAEffKANDELNQLKSGRESLQAAYDELLRSNAEAQKLLDKEREESEKRVA 1142
Cdd:COG1196   541 EAALAAALQNIVVEDDEVAAaaIEYLKAAKAG--RATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVL 618

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1143 DLHALNSNLHDQIEALASKLAVLASQsqnpnsSLNESAMDGDQSLNASGLTAAEEGRNNEQLLKIIKFLRKEKDLFAAKL 1222
Cdd:COG1196   619 GDTLLGRTLVAARLEAALRRAVTLAG------RLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEE 692

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1223 DILKAENARLISE-HAIQQKKVDELNGYLNQERAKSQTDVVSANKHEEVLRKIETLNAITDSNRILREERNALTLRVAEL 1301
Cdd:COG1196   693 LELEEALLAEEEEeRELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERL 772


                  ....
gi 442623382 1302 TDRI 1305
Cdd:COG1196   773 EREI 776
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
972-1552 1.43e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 73.56  E-value: 1.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  972 ESEIKRLHELHGELVAKQEEeIKKLRSSEAELKTRISDLEAE--AMLSNVTEQSKTVNQsgqLKSAQDDLKSLLEKLTEA 1049
Cdd:PRK03918  161 ENAYKNLGEVIKEIKRRIER-LEKFIKRTENIEELIKEKEKEleEVLREINEISSELPE---LREELEKLEKEVKELEEL 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1050 NCTIRTLRSENTSLVESLNAAEvkyangmiqhsADIQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSNAEAQKL 1129
Cdd:PRK03918  237 KEEIEELEKELESLEGSKRKLE-----------EKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEY 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1130 LDKEREeSEKRVADLHALNSNLHDQIEALASKLAVLA------SQSQNPNSSLNESAMDGDQSL----NASGLTAAEEGR 1199
Cdd:PRK03918  306 LDELRE-IEKRLSRLEEEINGIEERIKELEEKEERLEelkkklKELEKRLEELEERHELYEEAKakkeELERLKKRLTGL 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1200 NNEQLLKIIKFLRKEKDLFAAKLDILKAENARLISEHAIQQKKVDELngylnqERAKSQTDVVSANKHEEvlRKIETLNA 1279
Cdd:PRK03918  385 TPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEEL------KKAKGKCPVCGRELTEE--HRKELLEE 456

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1280 ITDSNRILREERNALTLRVAELTDRISSVEK------ELFPLQCSN---KELTSKIEEINVENTSLRT-EAIKWRQRANA 1349
Cdd:PRK03918  457 YTAELKRIEKELKEIEEKERKLRKELRELEKvlkkesELIKLKELAeqlKELEEKLKKYNLEELEKKAeEYEKLKEKLIK 536

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1350 LVEKSNRNPEEFKRLQAEREHLAKLLTAEKELNKKQSDELTVLKQRMNTEIPMLNKQMQILDEARKkqvdEFTNLKQnnt 1429
Cdd:PRK03918  537 LKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYN----EYLELKD--- 609

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1430 rQTQDIMELKNRLLQKEEELLKANEELETKDKTIADKETKELQLRKL-----AKRYKDFYIGLQSQGGGTEsaAELEKVR 1504
Cdd:PRK03918  610 -AEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKyseeeYEELREEYLELSRELAGLR--AELEELE 686

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 442623382 1505 SELEEVNNQLRALKDEHEKITKECDEVKKRTEPETDTSAIRQ---EYKAKL 1552
Cdd:PRK03918  687 KRREEIKKTLEKLKEELEEREKAKKELEKLEKALERVEELREkvkKYKALL 737
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
647-1139 8.83e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 70.86  E-value: 8.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  647 EESRKLEKRVRQLEQQLEGEVKKYASLKENYDYYTSEKRKNDALAQEQfDSMRKEVRELTSSNCKLMNTTEFQKEQIELL 726
Cdd:PRK03918  207 REINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSK-RKLEEKIRELEERIEELKKEIEELEEKVKEL 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  727 hKNIGTYKQQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSSRLQiEKETYHRE 806
Cdd:PRK03918  286 -KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLE-ELEERHEL 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  807 QQSQSLLLNSLEFIKTNLE-------RSEMEGRQRLEQRLDDTVRELAAQRRHFQEEEEKFRESINEFKRqAETAIKL-- 877
Cdd:PRK03918  364 YEEAKAKKEELERLKKRLTgltpeklEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKK-AKGKCPVcg 442

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  878 ----KDEEKQLADKWQAELTSVREELAEKVNKVNELSKKLQEVLTPTLNDNPITAANKRA---REFELKLDQATVE-IES 949
Cdd:PRK03918  443 reltEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAeqlKELEEKLKKYNLEeLEK 522

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  950 LTKELAKTREHGEQFYKMSQSAESEIKRLHELHGELvAKQEEEIKKLRSSEAELKTRISDL---EAEAMLSNVTEQSKTV 1026
Cdd:PRK03918  523 KAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKL-AELEKKLDELEEELAELLKELEELgfeSVEELEERLKELEPFY 601

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1027 NQSGQLKSAQDDLKSLLEKL-------TEANCTIRTLRSENTSLVESLNAAEVKYANGmiQHSADIQELTRYKAEFFKAN 1099
Cdd:PRK03918  602 NEYLELKDAEKELEREEKELkkleeelDKAFEELAETEKRLEELRKELEELEKKYSEE--EYEELREEYLELSRELAGLR 679

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 442623382 1100 DELNQLKSGRESLQAAYDELLRSNAEaqklLDKEREESEK 1139
Cdd:PRK03918  680 AELEELEKRREEIKKTLEKLKEELEE----REKAKKELEK 715
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 14-684 2.69e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 69.32  E-value: 2.69e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    14 QPDELKLVPEDVQKKLSEYINNFSDEYCKNRAAANRLAEAEQKKEELENKMEDYLVKFTSFELNVNELRTHLDQMSSERV 93
Cdd:TIGR02168  331 KLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLE 410

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    94 NLMDTIAKGEQTISQLRKEKASvveerdsmmKVIERQQAELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALE 173
Cdd:TIGR02168  411 RLEDRRERLQQEIEELLKKLEE---------AELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAE 481

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   174 LKENRMESERDMLHKEILLISGDLNKSNAELQNIRREHTIntmqlQSCLKEKTESlklmQEQYEQAVKT-IGELTSKIEM 252
Cdd:TIGR02168  482 RELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGI-----LGVLSELISV----DEGYEAAIEAaLGGRLQAVVV 552

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   253 QNDTAFKQNQATeeyvgkLKKELDAKEKLFEIFKSTESDHLIQREELLQGISEIKRLLEEAEEQCAQLTEQMETMKQ--- 329
Cdd:TIGR02168  553 ENLNAAKKAIAF------LKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGgvl 626

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   330 --KHSAELDEQNKKIQAMEQ------ELASANDLLKQARESNLESAICQLAPSAAVASRLIRSDLSLTELYSMYAKSSEE 401
Cdd:TIGR02168  627 vvDDLDNALELAKKLRPGYRivtldgDLVRPGGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKE 706

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   402 LEMRNCEIEQLKLQLKSIIAEISESAPILEKQNSDYQKMKETNSELLREHDELLQNKLCLERELERALSTLNHNQNENKK 481
Cdd:TIGR02168  707 LEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEE 786

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   482 LKQTHTDLSRQVCMLLDELNCIRAGVKHVRIQPTRQLPTSESLISDNLVTFSSIEELVDR----NTYLLNMSRELTELLE 557
Cdd:TIGR02168  787 LEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQieelSEDIESLAAEIEELEE 866

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   558 ASEKNQDKmlLEQSKNHIRKLDARFAELEDLLTQKNNTVTTLLSKCDRYKKLYFAAQKKLGQNTVDLD------DSNLEP 631
Cdd:TIGR02168  867 LIEELESE--LEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEglevriDNLQER 944

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442623382   632 -----NDSALDTSEQPAANFEESRKLEKRVRQLEQQLE--GEV-----KKYASLKENYDYYTSEK 684
Cdd:TIGR02168  945 lseeySLTLEEAEALENKIEDDEEEARRRLKRLENKIKelGPVnlaaiEEYEELKERYDFLTAQK 1009
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 652-1214 3.00e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 69.20  E-value: 3.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  652 LEKRVRQLEQQLEgEVKKYASLKENYDYYTSEKR-KNDALAQEQFDSMRKEVRELTSSNCKLMNTTEFQKEQIELLHKNI 730
Cdd:COG1196   198 LERQLEPLERQAE-KAERYRELKEELKELEAELLlLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLEL 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  731 GTYKQQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQ 810
Cdd:COG1196   277 EELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEA 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  811 SLLLNSLEFIKTNLERSEMEGRQRLEQRLDDTVR------ELAAQRRHFQEEEEKFRESINEFKRQAETAIKLKDEEKQL 884
Cdd:COG1196   357 EAELAEAEEALLEAEAELAEAEEELEELAEELLEalraaaELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEE 436

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  885 ADKWQAELTSVREELAEKVNKVNELSKKLQEVLTptlndnpiTAANKRAREFELKLDQATVEIESLTKELAKTREHGEQF 964
Cdd:COG1196   437 EEEEEEALEEAAEEEAELEEEEEALLELLAELLE--------EAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLE 508

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  965 YKMSQSAESEIKRLHELHGELVAKQEEEIK------------KLRSSEAELKTRISDLEAE----AMLSNVTEQSKTVNQ 1028
Cdd:COG1196   509 GVKAALLLAGLRGLAGAVAVLIGVEAAYEAaleaalaaalqnIVVEDDEVAAAAIEYLKAAkagrATFLPLDKIRARAAL 588

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1029 SGQLKSAQDDLKSLLEKLTEANCTIRTLRSENTSLVESLNAAEVKYANGMI-QHSADIQELTRYKAEFFKANDELNQLKS 1107
Cdd:COG1196   589 AAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAvTLAGRLREVTLEGEGGSAGGSLTGGSRR 668

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1108 GRESLQAAYDELLRSNAEAQKLLDKEREESEKRVADLHALNSNLHDQIEALASKLAVLASQSQNPNSSLNESAMDGDQSL 1187
Cdd:COG1196   669 ELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELL 748

                         570       580
                  ....*....|....*....|....*..
gi 442623382 1188 NASGLTAAEEGRNNEQLLKIIKFLRKE 1214
Cdd:COG1196   749 EEEALEELPEPPDLEELERELERLERE 775
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 415-1373 8.86e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 67.77  E-value: 8.86e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   415 QLKSIIAEISESAPILEKQNSDYQKMKETNSELlrehdellqnklcleRELERALSTLNHNQNENKklkqthtdlsrqvc 494
Cdd:TIGR02168  190 RLEDILNELERQLKSLERQAEKAERYKELKAEL---------------RELELALLVLRLEELREE-------------- 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   495 mlLDELNCIRAGVKHVRIQPTRQLPTSESLISDNLVTFSSIEELVDRNTyllnmsrelTELLEASEKNQDKmlleqsKNH 574
Cdd:TIGR02168  241 --LEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQ---------KELYALANEISRL------EQQ 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   575 IRKLDARFAELEDLLTQKNNTVTTLLSKCDRYKKLYFAAQKKLGQNTVDLDDsnlepndsaldTSEQPAANFEESRKLEK 654
Cdd:TIGR02168  304 KQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELES-----------LEAELEELEAELEELES 372

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   655 RVRQLEQQLEGEVKKYASLKENYDYYTSEKRKNDALAQEQFDSMRKEVRELTSSNcklmntTEFQKEQIELLHKNIGTYK 734
Cdd:TIGR02168  373 RLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELL------KKLEEAELKELQAELEELE 446

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   735 QQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQSLLL 814
Cdd:TIGR02168  447 EELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLS 526

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   815 NSLEF---IKTNLERSEMEGRQRLEQRLDDTVRELAAqrrhFQEEEEKFRESINEFKRQAETAIKLKDEEKQladkwqAE 891
Cdd:TIGR02168  527 ELISVdegYEAAIEAALGGRLQAVVVENLNAAKKAIA----FLKQNELGRVTFLPLDSIKGTEIQGNDREIL------KN 596

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   892 LTSVREELAEKVNKVNELSKKLQEVLTPTLNDNPITAANKRAREFELKLDQATVEIESLTKELAKTREHGEQFYKMsQSA 971
Cdd:TIGR02168  597 IEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELAKKLRPGYRIVTLDGDLVRPGGVITGGSAKTNSSI-LER 675

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   972 ESEIKRLhelhgelvakqEEEIKKLRSSEAELKTRISDLEAEamLSNVTEQSKTVNQsgQLKSAQDDLKSLLEKLTEANC 1051
Cdd:TIGR02168  676 RREIEEL-----------EEKIEELEEKIAELEKALAELRKE--LEELEEELEQLRK--ELEELSRQISALRKDLARLEA 740

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1052 TIRTLRSENTSLVESLNAAEvkyangmiqhsadiQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSNAEAQKLLD 1131
Cdd:TIGR02168  741 EVEQLEERIAQLSKELTELE--------------AEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALD 806

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1132 KEREEsekrvadLHALNSNLHDQIEALASKLAvlasqsqnpnsslnesamdgdqslnasglTAAEEGRNNEQLLKIIKFL 1211
Cdd:TIGR02168  807 ELRAE-------LTLLNEEAANLRERLESLER-----------------------------RIAATERRLEDLEEQIEEL 850

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1212 RKEKDLFAAKLDILKAENARLISEHAIQQKKVDELNGYLNQERAKSQTDVVSANKHEEVLRKIET-LNAITDSNRILREE 1290
Cdd:TIGR02168  851 SEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRReLEELREKLAQLELR 930

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1291 RNALTLRVAELTDRISSVEKELFPLQcsnKELTSKIEEinvENTSLRTEAIKWRQRANALVEKSNRNPEEFKRLQAEREH 1370
Cdd:TIGR02168  931 LEGLEVRIDNLQERLSEEYSLTLEEA---EALENKIED---DEEEARRRLKRLENKIKELGPVNLAAIEEYEELKERYDF 1004


                   ...
gi 442623382  1371 LAK 1373
Cdd:TIGR02168 1005 LTA 1007
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 268-1144 2.05e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 66.63  E-value: 2.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   268 VGKLKKELDAKEKLFEIFKSTE----SDHLIQREELLQGISEIKRLLEEAEEQCAQLTEQMETMKQKHSA---ELDEQNK 340
Cdd:TIGR02169  200 LERLRREREKAERYQALLKEKReyegYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEieqLLEELNK 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   341 KIQAM--EQELASANDLLK-QARESNLESAIcqlapsAAVASRLIRSDLSLTELYSMYAKSSEELEMRNCEIEQLKLQLK 417
Cdd:TIGR02169  280 KIKDLgeEEQLRVKEKIGElEAEIASLERSI------AEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRD 353

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   418 SIIAEISESAPILEKQNSDYQKMKETNSELLREHDELLQNKLCLERELERALSTLNHNQNENKKLKQTHTDLSRQVCMLL 497
Cdd:TIGR02169  354 KLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIE 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   498 DELNCIRAGVKHVRIQpTRQLPTSESLISDNLVTFSsiEELVDRNTYLLNMSRELTELLEASEKnqdkmlLEQSKNHIRK 577
Cdd:TIGR02169  434 AKINELEEEKEDKALE-IKKQEWKLEQLAADLSKYE--QELYDLKEEYDRVEKELSKLQRELAE------AEAQARASEE 504

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   578 LDARFAELEDLLTQKNNTVTTLLSKCDRYKKLYFAAQKKLG----QNTVDLDDSNLEPNDSALDTSEQPAANFEESRKLE 653
Cdd:TIGR02169  505 RVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAgnrlNNVVVEDDAVAKEAIELLKRRKAGRATFLPLNKMR 584

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   654 KRVRQLEQQLEGEVKKYAslkenYDYYTSEKRKNDALAQeqfdsmrkevreltssncKLMNTTEFqkEQIELLHKNIGTY 733
Cdd:TIGR02169  585 DERRDLSILSEDGVIGFA-----VDLVEFDPKYEPAFKY------------------VFGDTLVV--EDIEAARRLMGKY 639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   734 KqqVTTLEERTknYEKTiikheqtvhllkDEMMAAHRKHAAADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQSLL 813
Cdd:TIGR02169  640 R--MVTLEGEL--FEKS------------GAMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENR 703

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   814 LNSLefiktnleRSEMEGRQRleqrlddTVRELAAQRRHFQEEEEKFRESINEFKRQAETAIKLKDEEKQLADKWQAELT 893
Cdd:TIGR02169  704 LDEL--------SQELSDASR-------KIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIE 768

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   894 SVREELAEKVNKVNELSKKLQEVLTPTLNDNpITAANKRAREFELKLDQATVEIESLTKE---LAKTREHGEQFYKMSQS 970
Cdd:TIGR02169  769 ELEEDLHKLEEALNDLEARLSHSRIPEIQAE-LSKLEEEVSRIEARLREIEQKLNRLTLEkeyLEKEIQELQEQRIDLKE 847

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   971 AESEI-KRLHELHGELvAKQEEEIKKLRSSEAELKTRISDLEAEamLSNVTEQSKTVNQS-GQLKSAQDDLKSLLEKLTE 1048
Cdd:TIGR02169  848 QIKSIeKEIENLNGKK-EELEEELEELEAALRDLESRLGDLKKE--RDELEAQLRELERKiEELEAQIEKKRKRLSELKA 924

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1049 ancTIRTLRSENTSLVEslNAAEVKYANGMIQHSADIQELTRYKAEFFKANDELNQLKSGR-ESLQAAYDELlrsnAEAQ 1127
Cdd:TIGR02169  925 ---KLEALEEELSEIED--PKGEDEEIPEEELSLEDVQAELQRVEEEIRALEPVNMLAIQEyEEVLKRLDEL----KEKR 995

                          890
                   ....*....|....*..
gi 442623382  1128 KLLDKEREESEKRVADL 1144
Cdd:TIGR02169  996 AKLEEERKAILERIEEY 1012
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 103-367 2.53e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 66.11  E-value: 2.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  103 EQTISQLRKEKASVVEERDSMMKVIERQQAELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELKENRMESE 182
Cdd:COG1196   238 EAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEER 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  183 RDMLHKEILLISGDLNKSNAELQNIRREhtintmqlqscLKEKTESLKLMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQ 262
Cdd:COG1196   318 LEELEEELAELEEELEELEEELEELEEE-----------LEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  263 ATEEyvgKLKKELDAKEKLFEIfKSTESDHLIQREELLQGISEIKRLLEEAEEQCAQLTEQMETMKQKHSAELDEQNKKI 342
Cdd:COG1196   387 ELLE---ALRAAAELAAQLEEL-EEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALL 462

                         250       260
                  ....*....|....*....|....*
gi 442623382  343 QAMEQELASANDLLKQARESNLESA 367
Cdd:COG1196   463 ELLAELLEEAALLEAALAELLEELA 487
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 635-1481 1.04e-09

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 64.30  E-value: 1.04e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   635 ALDTSEQPAANFEESRK---LEKRVRQLEQQLEGEVKKYASLKENYDYYTSEKRKNDALAQEQFDSMRKEVRELTSSNCK 711
Cdd:TIGR00606  187 ALETLRQVRQTQGQKVQehqMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIMK 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   712 LMNT-TEFQKEQIELLHKNIGTYKQQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQENRILR 790
Cdd:TIGR00606  267 LDNEiKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKTELL 346

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   791 DTSSRLQIEKETYHREQQSQSLLLNSLEFiktnleRSEMEGRQR--------------LEQRLDDTVRELAAQRRHFQEE 856
Cdd:TIGR00606  347 VEQGRLQLQADRHQEHIRARDSLIQSLAT------RLELDGFERgpfserqiknfhtlVIERQEDEAKTAAQLCADLQSK 420

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   857 EEKFRESINEFKRQAETAIKLKDEEKQLADKWQAELTSVREELAEKVNKVNELSKKLQEvLTPTLNDNPITAAN-----K 931
Cdd:TIGR00606  421 ERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQE-LRKAERELSKAEKNsltetL 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   932 RAREFELKLDQATV---------EIESLTKElAKTREHGEQFYKMSQSAESEIKRLHELHGELVAKQ----------EEE 992
Cdd:TIGR00606  500 KKEVKSLQNEKADLdrklrkldqEMEQLNHH-TTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLlgyfpnkkqlEDW 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   993 IKKLRSSEAELKTRISDLEAEAMLSnvtEQSKTvNQSGQLKSAQDDLKSLLEKLTEAnCTIRTLRSENTSLVESLNAAEV 1072
Cdd:TIGR00606  579 LHSKSKEINQTRDRLAKLNKELASL---EQNKN-HINNELESKEEQLSSYEDKLFDV-CGSQDEESDLERLKEEIEKSSK 653

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1073 KYA---NGMIQHSADIQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSNAEAQKLLDKEREESEKRVADLHALNS 1149
Cdd:TIGR00606  654 QRAmlaGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAP 733

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1150 NLHDQIEALASKLAVLASQSQNPNSSLNESAMDGDQSLNASGLTAAEEGRNNEQLLKIIKFLRKEKDLfaakldilkAEN 1229
Cdd:TIGR00606  734 GRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMEL---------KDV 804

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1230 ARLISEHAIQQKKVDELNGY--LNQERAKSQTDVVSANKHEEVLRK-IETLNAITDSNRILREERNALTLRVAELTDRIS 1306
Cdd:TIGR00606  805 ERKIAQQAAKLQGSDLDRTVqqVNQEKQEKQHELDTVVSKIELNRKlIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQ 884

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1307 SVEKELFPLQCSNKELTSKIEEINVENTSLRTEAIKWRQRANALVEKSN-RNPEEFKRLQAEREHLAKLLTAEKELNKKQ 1385
Cdd:TIGR00606  885 QFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKEtSNKKAQDKVNDIKEKVKNIHGYMKDIENKI 964

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1386 SDELTVLKQRMNTEIPMLNKQMQILDEARKKqvdefTNLKQNNTRQTQDIMELKNRLLQKEEELLKANEELETKDKTIA- 1464
Cdd:TIGR00606  965 QDGKDDYLKQKETELNTVNAQLEECEKHQEK-----INEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEELKq 1039

                          890
                   ....*....|....*...
gi 442623382  1465 -DKETKELQLRKLAKRYK 1481
Cdd:TIGR00606 1040 hLKEMGQMQVLQMKQEHQ 1057
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 31-909 3.03e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 62.68  E-value: 3.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    31 EYINNFSDEYCKNRAaaNRLAEAEQKKEELENKM----EDYLVKFTSFELNVNELRTHLDQMSSERVNLMDTIAKGEQTI 106
Cdd:pfam02463  183 ENLAELIIDLEELKL--QELKLKEQAKKALEYYQlkekLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEI 260

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   107 SQLRKEKASVVEERDSMMKVIERQQAELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELKENRMESERDML 186
Cdd:pfam02463  261 EKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEEL 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   187 HKEILLISGDLNKSNAELQNIRREHTINTMQLQsclkEKTESLKLMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQATEE 266
Cdd:pfam02463  341 EKELKELEIKREAEEEEEEELEKLQEKLEQLEE----ELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQ 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   267 YVGKLKKELDAKEKLFEIFKStesdhliqREELLQGISEIKRLLEEAEEQCAQLTEQMETMKQKHSAELDEQNKKIQAME 346
Cdd:pfam02463  417 LEDLLKEEKKEELEILEEEEE--------SIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLEL 488

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   347 QELASANDLLKQARESNLESAICQLAPSAAVASRLIRSDLSLTELYSMYAKSSEELEMRNCEIEQLKlqLKSIIAEISES 426
Cdd:pfam02463  489 LLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSA--TADEVEERQKL 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   427 APILEKQNSDYQKmketnselLREHDELLQNKLCLERELERALSTLNHNQNENKKLKQTHTDLSRQVCMLLDELNCIRAG 506
Cdd:pfam02463  567 VRALTELPLGARK--------LRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLK 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   507 VKHVRIQPTRQLPTSESLISDNLVTFSSIEELVDRNTYLLNMSRELTELLEASEKNQDKMLLEQSKNHIRKLDARFAELE 586
Cdd:pfam02463  639 ESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLE 718

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   587 DLLtQKNNTVTTLLSKCDRYKKLYFAAQKKLGQNTVDLDDSNLEPNDSALDTSEQpaanfeESRKLEKRVRQLEQQLEGE 666
Cdd:pfam02463  719 AEE-LLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLK------EKELAEEREKTEKLKVEEE 791

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   667 VKKYASLKENydyytsEKRKNDALAQEQFDSMRKEVRELTSSNCKlmnttefQKEQIELLHKNIGTYKQQVTTLEERTKN 746
Cdd:pfam02463  792 KEEKLKAQEE------ELRALEEELKEEAELLEEEQLLIEQEEKI-------KEEELEELALELKEEQKLEKLAEEELER 858

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   747 YEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQSLLLNSLEFIKTNLER 826
Cdd:pfam02463  859 LEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPE 938

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   827 sEMEGRQRLEQRLDDTVRELAAQRRHFQEEEEKFRESIN-------EFKRQAETAIKLKDEEKQLADKWQAELTsvREEL 899
Cdd:pfam02463  939 -ELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNlmaieefEEKEERYNKDELEKERLEEEKKKLIRAI--IEET 1015

                          890
                   ....*....|
gi 442623382   900 AEKVNKVNEL 909
Cdd:pfam02463 1016 CQRLKEFLEL 1025
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 647-1158 7.56e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 61.49  E-value: 7.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  647 EESRKLEKRVRQLEQQLEGEVKKYASLKENYDYYTSEK---RKNDALAQEQFDSMRKEVRELTSSNCKLMNTTEFQKEQI 723
Cdd:COG1196   260 AELAELEAELEELRLELEELELELEEAQAEEYELLAELarlEQDIARLEERRRELEERLEELEEELAELEEELEELEEEL 339

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  724 ELLHKNIGTYKQQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSSRLQIEKETY 803
Cdd:COG1196   340 EELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERL 419

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  804 HREQQSQSLLLNSLEfIKTNLERSEMEGRQRLEQRLDDTVRELAAQRRHFQEEEEKFRESINEFKRQAETAIKLKDEEKQ 883
Cdd:COG1196   420 EEELEELEEALAELE-EEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLE 498

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  884 LADKWQAELTSVREELAEKVNKVNELSKKLQEVLTPTLNDNPITAANKRAREFELKLDQATVEIESLTKELAKTREHGEQ 963
Cdd:COG1196   499 AEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLP 578

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  964 FYKMSQSAESEIKRLHELHGELVA------KQEEEIKKLRSSEAELKTRISDLEAEAM---------LSNVTEQSKTVNQ 1028
Cdd:COG1196   579 LDKIRARAALAAALARGAIGAAVDlvasdlREADARYYVLGDTLLGRTLVAARLEAALrravtlagrLREVTLEGEGGSA 658

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1029 SGQLKSAQddLKSLLEKLTEANCTIRTLRSENTSLVESLNAAEVKYANGMIQHSADIQELTRYKAEFFKANDELNQLKSG 1108
Cdd:COG1196   659 GGSLTGGS--RRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREE 736

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 442623382 1109 RESLQAAYDELLRSNAEAQKLLDKEREESEKRVADLHAlnsnlhdQIEAL 1158
Cdd:COG1196   737 LLEELLEEEELLEEEALEELPEPPDLEELERELERLER-------EIEAL 779
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1298-1623 9.07e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 61.24  E-value: 9.07e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1298 VAELTDRISSVEKELFPLQCSNKELTSKIEEINVENTSLRTEaikwrqRANAlveksnrnpEEFKRLQAER------EHL 1371
Cdd:TIGR02169  165 VAEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRRE------REKA---------ERYQALLKEKreyegyELL 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1372 AKLLTAEKELNK--KQSDELTVLKQRMNTEIPMLNKQM----QILDEA----RKKQVDEFTNLK------QNNTRQTQDI 1435
Cdd:TIGR02169  230 KEKEALERQKEAieRQLASLEEELEKLTEEISELEKRLeeieQLLEELnkkiKDLGEEEQLRVKekigelEAEIASLERS 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1436 MELKNRLLQK-EEELLKANEELETKDKTIADKETKELQLRKLAKRYKDFYIglqsqgggtESAAELEKVRSELEEVNNQL 1514
Cdd:TIGR02169  310 IAEKERELEDaEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYA---------ELKEELEDLRAELEEVDKEF 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1515 RALKDEHEKITKECDEVKKRTEPETDTSAIRQEYKAKLDKLVVDLTVARTDLVNQETTFAGTKSSYDETIARLEKELQEN 1594
Cdd:TIGR02169  381 AETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQL 460

                          330       340       350
                   ....*....|....*....|....*....|..
gi 442623382  1595 IAANKDINQRLTR---ENESLHMRINQLTRQL 1623
Cdd:TIGR02169  461 AADLSKYEQELYDlkeEYDRVEKELSKLQREL 492
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1211-1509 9.83e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 61.11  E-value: 9.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1211 LRKEKDLFAAKLDILKAENARLisEHAIQQKKVDELNgylnQERAKSQTDVVSANKHEEVLRkiETLNAitdsnriLREE 1290
Cdd:COG1196   218 LKEELKELEAELLLLKLRELEA--ELEELEAELEELE----AELEELEAELAELEAELEELR--LELEE-------LELE 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1291 RNALTLRVAELTDRISSVEKELFPLQCSNKELTSKIEEINVENTSLRTEAIKWRQRANALVEKSNRNPEEFKRLQAEREH 1370
Cdd:COG1196   283 LEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAE 362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1371 L-AKLLTAEKELNKKQSDELTVLKQRMNTEIPMLNKQMQILDEARKKQvdeftNLKQNNTRQTQDIMELKNRLLQKEEEL 1449
Cdd:COG1196   363 AeEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEE-----ALLERLERLEEELEELEEALAELEEEE 437

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1450 LKANEELETKDKTIADKETKELQLRKLAKRYKDFYIGLQSQGGGTESAAELEKVRSELEE 1509
Cdd:COG1196   438 EEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLL 497
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 925-1177 1.35e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 59.39  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  925 PITAANKRAREFELKLDQATVEIESLTKELAKTREHGEQFYKMSQSAESEIKRLHelhgELVAKQEEEIKKLRSSEAELK 1004
Cdd:COG4942    14 AAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALA----RRIRALEQELAALEAELAELE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1005 TRISDLEAEamLSNVTEQSKTVNQSGQLKSAQDDLKSLLEKlTEANCTIRTLRsentsLVESLNAAEVKYANGMiqhSAD 1084
Cdd:COG4942    90 KEIAELRAE--LEAQKEELAELLRALYRLGRQPPLALLLSP-EDFLDAVRRLQ-----YLKYLAPARREQAEEL---RAD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1085 IQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSNAEAQKLLDKEREESEKRVADLHALNSNLHDQIEALASKLAV 1164
Cdd:COG4942   159 LAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238

                         250
                  ....*....|...
gi 442623382 1165 LASQSQNPNSSLN 1177
Cdd:COG4942   239 AAERTPAAGFAAL 251
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 820-1613 1.52e-08

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 60.37  E-value: 1.52e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   820 IKTNLERSEMEGRQRLEQRLDDTVRELAAQRRHFQEEEEKFRESINEFKRQAETAIKLKDEEKQLADKWQAELTSVREEL 899
Cdd:pfam02463  170 KKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDE 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   900 AEKVNKVNELSKKLQEVLTPTLNDNPITAANKRAREFELKLDQATVEIESLTKELAKTR-EHGEQFYKMSQSAESEIKRL 978
Cdd:pfam02463  250 QEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRkVDDEEKLKESEKEKKKAEKE 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   979 HELHGELVAKQEEEIKKLRSSEAELKTRISDLEAEAMLSNVTEQSKTVNQSGQLKSAQDDLKSLLEKLTEANCTIRTLRS 1058
Cdd:pfam02463  330 LKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQL 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1059 ENTSLVESLNAAevkyangmiqhsadiQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSnAEAQKLLDKEREESE 1138
Cdd:pfam02463  410 LLELARQLEDLL---------------KEEKKEELEILEEEEESIELKQGKLTEEKEELEKQEL-KLLKDELELKKSEDL 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1139 KRVADLHALNSNLHDQIEALASKLAVLASQSQNPNSSLNESAMDGDQSLNASGltaaEEGRNNEQLLKIIKFLRKEKDLF 1218
Cdd:pfam02463  474 LKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIIS----AHGRLGDLGVAVENYKVAISTAV 549

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1219 AAKLDILKAEnarlISEHAIQQKKVDELNGYLNQERAKSQTDVVSANKHEEVLRKIETLNAITDSNRILREERNALTLRV 1298
Cdd:pfam02463  550 IVEVSATADE----VEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVV 625

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1299 ---AELTDRISSVEKELFPLQCSNKELTSKIEEINVENTSLRTEAIKWRQRANALVEKSNRNPEEFKRLQAEREHLAKLL 1375
Cdd:pfam02463  626 egiLKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKE 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1376 TAEKELNKKQSDELTVLKQRMNTEIpmLNKQMQILDEARKKQVDEFTNLKQNNTRQTQDIMELKNRLLQKEEELLKANEE 1455
Cdd:pfam02463  706 QREKEELKKLKLEAEELLADRVQEA--QDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKT 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1456 LETKDKTIADKETKELQLRKLAKRYKDFYIGLQSQGGGTESAAELEKVRSELEEVNNQLRALKDEHEKITKECDEVKKRT 1535
Cdd:pfam02463  784 EKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEI 863

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442623382  1536 EPETDTSAIRQEYKAKLDKLVVDLTVARTDLVNQETTFAGTKSSYDETIARLEKELQENIAANKDINQRLTRENESLH 1613
Cdd:pfam02463  864 TKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELL 941
PTZ00121 PTZ00121
MAEBL; Provisional
 828-1555 1.78e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 60.54  E-value: 1.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  828 EMEGRQRLEQRLDDTVRELAAQRRHFQEEEEKFRESINEFKRQAETAIKLKDEEKQLADKWQAEltSVREelAEKVNKVN 907
Cdd:PTZ00121 1068 QDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAE--EARK--AEDARKAE 1143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  908 ElSKKLQEVLTPTLNDNPITAanKRAREFELKLDQATVEIESLTKELAKTRE--HGEQFYKMSQSAESE-IKRLHELHGE 984
Cdd:PTZ00121 1144 E-ARKAEDAKRVEIARKAEDA--RKAEEARKAEDAKKAEAARKAEEVRKAEElrKAEDARKAEAARKAEeERKAEEARKA 1220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  985 LVAKQEEEIKKL---RSSEAELKTRISDLEAEAMLSNVTEQSKTVNQSGQLKSAQDDLKS-LLEKLTEANCTIRTLRSEN 1060
Cdd:PTZ00121 1221 EDAKKAEAVKKAeeaKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKAdELKKAEEKKKADEAKKAEE 1300

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1061 TSLVESLN--AAEVKYANGMIQHSADIQ---ELTRYKAEFFKANDELNQLKSgreslQAAYDELlrSNAEAQKLLDKERE 1135
Cdd:PTZ00121 1301 KKKADEAKkkAEEAKKADEAKKKAEEAKkkaDAAKKKAEEAKKAAEAAKAEA-----EAAADEA--EAAEEKAEAAEKKK 1373

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1136 ESEKRVADLHALNSNLHDQIEALASKlavlASQSQNPNSSLNESAMDGDQSLNASglTAAEEGRNNEQLLKIIKFLRKEK 1215
Cdd:PTZ00121 1374 EEAKKKADAAKKKAEEKKKADEAKKK----AEEDKKKADELKKAAAAKKKADEAK--KKAEEKKKADEAKKKAEEAKKAD 1447

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1216 DLFAAKLDILKAENARLISEHAiqqKKVDELNGYLNQERA--KSQTDVVSANKHEEVLRKIETLNAITDSNRILREERNA 1293
Cdd:PTZ00121 1448 EAKKKAEEAKKAEEAKKKAEEA---KKADEAKKKAEEAKKadEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKA 1524

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1294 LTLRVAELTDRISSVEKelfplqcsnKELTSKIEEINVENTSLRTEAIKWRQRANALVEKSN---RNPEEFKrlQAEREH 1370
Cdd:PTZ00121 1525 DEAKKAEEAKKADEAKK---------AEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNmalRKAEEAK--KAEEAR 1593

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1371 LAKLLTAEKELNKKQSDELtvlkqRMNTEIPMLNKQMQILDEARKKQVDEFTNLKQNNTRQTQDIMELKNRLLQKEEELL 1450
Cdd:PTZ00121 1594 IEEVMKLYEEEKKMKAEEA-----KKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAK 1668

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1451 KANEELETKDKTIADKETKELQLRKLAKRYKDFYIGLQSQGGGTESAAELEKVRSELEEVNNQLRALKDEHEKITKECDE 1530
Cdd:PTZ00121 1669 KAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEE 1748

                         730       740
                  ....*....|....*....|....*
gi 442623382 1531 VKKRTEPETDTSAIRQEYKAKLDKL 1555
Cdd:PTZ00121 1749 AKKDEEEKKKIAHLKKEEEKKAEEI 1773
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 931-1629 3.31e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 59.30  E-value: 3.31e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   931 KRAREFELKLDQATVEIESLTKELAKTREHGEQFYKMSQSAEseikRLHELHGELVAKQ-----------EEEIKKLRSS 999
Cdd:TIGR02168  172 ERRKETERKLERTRENLDRLEDILNELERQLKSLERQAEKAE----RYKELKAELRELElallvlrleelREELEELQEE 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1000 EAELKTRISDLEAEamLSNVTEQSKTVN-QSGQLKSAQDDLKSLLEKLTEAnctIRTLRSENTSLVESLNAAEVKYANGM 1078
Cdd:TIGR02168  248 LKEAEEELEELTAE--LQELEEKLEELRlEVSELEEEIEELQKELYALANE---ISRLEQQKQILRERLANLERQLEELE 322

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1079 IQHSADIQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSNAEAQKLLDKEREESEKRVADLHALN---------- 1148
Cdd:TIGR02168  323 AQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLElqiaslnnei 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1149 SNLHDQIEALASKLAVLASQSQNPNSSLNESAMDGDQS----LNASGLTAAEEGRNNEQLLKIIkflRKEKDLFAAKLDI 1224
Cdd:TIGR02168  403 ERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAeleeLEEELEELQEELERLEEALEEL---REELEEAEQALDA 479

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1225 LKAENARLISEHAIQQKKVDELNGY--------LNQERAKSQTDVVSANKH---------EEVLRK------IETLNAIT 1281
Cdd:TIGR02168  480 AERELAQLQARLDSLERLQENLEGFsegvkallKNQSGLSGILGVLSELISvdegyeaaiEAALGGrlqavvVENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1282 DSNRILREER---------NALTLRVAELTDRISSVEKELFPLQCSNKELTSKIEEINVEN--------TSLRT------ 1338
Cdd:TIGR02168  560 KAIAFLKQNElgrvtflplDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYllggvlvvDDLDNalelak 639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1339 -------------EAIKWR--------QRANALVEKSN---RNPEEFKRLQAE-REHLAKLLTAEKELN--KKQSDELTV 1391
Cdd:TIGR02168  640 klrpgyrivtldgDLVRPGgvitggsaKTNSSILERRReieELEEKIEELEEKiAELEKALAELRKELEelEEELEQLRK 719

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1392 LKQRMNTEIPMLNKQMQILDEARKKQVDEFTNLKQNNTRQTQDIMELKNRLLQKEEELLKANEELETKDKTIA----DKE 1467
Cdd:TIGR02168  720 ELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEqlkeELK 799

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1468 TKELQLRKLAKRYKDFYIGLQSQGGGTES-AAELEKVRSELEEVNNQLRALKDEHEKITKECDEvkKRTEPETDTSAIRQ 1546
Cdd:TIGR02168  800 ALREALDELRAELTLLNEEAANLRERLESlERRIAATERRLEDLEEQIEELSEDIESLAAEIEE--LEELIEELESELEA 877

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1547 EYKAKlDKLVVDLTVARTDLVNQETTFAgtksSYDETIARLEKELQENIAANKDINQRLtrenESLHMRINQLTRQLGSQ 1626
Cdd:TIGR02168  878 LLNER-ASLEEALALLRSELEELSEELR----ELESKRSELRRELEELREKLAQLELRL----EGLEVRIDNLQERLSEE 948


                   ...
gi 442623382  1627 QST 1629
Cdd:TIGR02168  949 YSL 951
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 44-316 4.21e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.79  E-value: 4.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   44 RAAANRLAEAEQKKEELENKMEDYLVKFTSFELNVNELRTHLDQMSSERVNLMDTIAKGEQTISQLRKEKASVVEERDSM 123
Cdd:COG1196   235 RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRREL 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  124 MKVIERQQAELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELKENRMESERDMLHKEILLISGDLNKSNAE 203
Cdd:COG1196   315 EERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA 394

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  204 LQNIRREHTINTMQLQSCLKEKTEslklMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQATEEYVGKLKKELDAKEKLFE 283
Cdd:COG1196   395 AAELAAQLEELEEAEEALLERLER----LEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLE 470

                         250       260       270
                  ....*....|....*....|....*....|...
gi 442623382  284 IFKSTESDHLIQREELLQGISEIKRLLEEAEEQ 316
Cdd:COG1196   471 EAALLEAALAELLEELAEAAARLLLLLEAEADY 503
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 44-317 6.15e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.41  E-value: 6.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   44 RAAANRLAEAEQKKEELENKMEDYLVKFTSFELNVNELRTHLDQMSSERVNLMDTIAKGEQTISQLRKEKASVVEERDSM 123
Cdd:COG1196   249 EELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAEL 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  124 MKVIERQQAELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELKENRMESERDMLHKEILLISGDLNKSNAE 203
Cdd:COG1196   329 EEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEA 408

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  204 LQNIRREHTINTMQLQSCLKEKTESLKLMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQATEEYVGKLKKELDAKEKLFE 283
Cdd:COG1196   409 EEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAE 488

                         250       260       270
                  ....*....|....*....|....*....|....
gi 442623382  284 ifKSTESDHLIQREELLQGISEIKRLLEEAEEQC 317
Cdd:COG1196   489 --AAARLLLLLEAEADYEGFLEGVKAALLLAGLR 520
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 51-1016 1.87e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 57.00  E-value: 1.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    51 AEAEQKKEELENKMEDYLVKFTSFELNVNELRTHLDQMSSERVNLMDTIAKGEQTISQLRKEKASVVEERDSMMKVIERQ 130
Cdd:TIGR02169  166 AEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQ 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   131 QAELERLKQDLhtyqQQLSSAIAAKCEAIARVDEIQSKEValelkenrmeseRDMLHKEILLISGDLNKSNAELQNIRRE 210
Cdd:TIGR02169  246 LASLEEELEKL----TEEISELEKRLEEIEQLLEELNKKI------------KDLGEEEQLRVKEKIGELEAEIASLERS 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   211 htintmqlqscLKEKTESLKLMQEQYEQAVKTIGELTSKIEmqndtafkqnqATEEYVGKLKKEldaKEKLFEIFKSTES 290
Cdd:TIGR02169  310 -----------IAEKERELEDAEERLAKLEAEIDKLLAEIE-----------ELEREIEEERKR---RDKLTEEYAELKE 364

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   291 dhliQREELLQGISEIKRLLEEAEEQCAQLTEQMETMKQKHSAELDEQNKKI---QAMEQELASANDLLKQARESNLESA 367
Cdd:TIGR02169  365 ----ELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQeelQRLSEELADLNAAIAGIEAKINELE 440

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   368 icqlapsaavasrlirsdlsltelysmyakssEELEMRNCEIEQLKLQLKSIIAEISESAPILEKQNSDYQKMKETNSEL 447
Cdd:TIGR02169  441 --------------------------------EEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKL 488

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   448 LREHDELLQNKLCLEREleralstlnhnQNENKKLKQTHTDLSRQVCMLLDELncIRAGVKHVR-IQPTRQLPTSESLIS 526
Cdd:TIGR02169  489 QRELAEAEAQARASEER-----------VRGGRAVEEVLKASIQGVHGTVAQL--GSVGERYATaIEVAAGNRLNNVVVE 555

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   527 DNLVTFSSIEELVDRN----TYL-LNMSRELTELLEASEKNQdkmLLEQSKNHIRkLDARFAELEDLLTQKnntvTTLLS 601
Cdd:TIGR02169  556 DDAVAKEAIELLKRRKagraTFLpLNKMRDERRDLSILSEDG---VIGFAVDLVE-FDPKYEPAFKYVFGD----TLVVE 627

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   602 KCDrykklyfAAQKKLGQ-NTVDLDDSNLEPNDSALDTSEQPAANFEESRKLEKRVRQLEQQLEGEVKKYASLKenydyy 680
Cdd:TIGR02169  628 DIE-------AARRLMGKyRMVTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQ------ 694

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   681 tSEKRKNDALAQEQFDSMR---KEVRELTSSNCKLMNTTEFQKEQIELLHKNIGTYKQQVTTLEERTKNYEKTIIKHEQT 757
Cdd:TIGR02169  695 -SELRRIENRLDELSQELSdasRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEED 773

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   758 VHLLKDEMMAAHRKHaaADAEAQSLRQENRILRDTSSRlqIEKETYHREQQsqsllLNSLEFIKTNLErSEMEGRQRLeq 837
Cdd:TIGR02169  774 LHKLEEALNDLEARL--SHSRIPEIQAELSKLEEEVSR--IEARLREIEQK-----LNRLTLEKEYLE-KEIQELQEQ-- 841

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   838 rlddtVRELAAQRRHFQEEEEKFRESINEFKRQ-AETAIKLKDEEKQLADkWQAELTSVREELAEKVNKVNELSKKLQEV 916
Cdd:TIGR02169  842 -----RIDLKEQIKSIEKEIENLNGKKEELEEElEELEAALRDLESRLGD-LKKERDELEAQLRELERKIEELEAQIEKK 915

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   917 ltpTLNDNPITAANKRAREFELKLDQATVEIESLTKELAKTrehgEQFYKMSQSAESEIKRLHELHgeLVAKQEEEIKKL 996
Cdd:TIGR02169  916 ---RKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSL----EDVQAELQRVEEEIRALEPVN--MLAIQEYEEVLK 986

                          970       980
                   ....*....|....*....|
gi 442623382   997 RSSEAELKTRISDLEAEAML 1016
Cdd:TIGR02169  987 RLDELKEKRAKLEEERKAIL 1006
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
23-493 1.90e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 56.61  E-value: 1.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   23 EDVQKKLSEYINNFSDEYCKNRAAANRLAEAEQKKEELENKMEDYLVKFTSFELNVNELRTHLDQMSSERVNLmdtiakg 102
Cdd:PRK03918  213 SSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKEL------- 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  103 eQTISQLRKEKASVVEERDSMMKVIERQQAELERLKQDLHTYQQQLSSAIAAKceaiARVDEIQSKEVALELKENRMEsE 182
Cdd:PRK03918  286 -KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKE----ERLEELKKKLKELEKRLEELE-E 359

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  183 RDMLHKEILLISGDLNKSNAELQNIRREHTINtmQLQSCLKEKTEslklMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQ 262
Cdd:PRK03918  360 RHELYEEAKAKKEELERLKKRLTGLTPEKLEK--ELEELEKAKEE----IEEEISKITARIGELKKEIKELKKAIEELKK 433

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  263 A-----------TEEYVGKL--------------KKELDAKE-KLFEIFKSTESDHLIQRE--ELLQGISEIKRLLEEAE 314
Cdd:PRK03918  434 AkgkcpvcgrelTEEHRKELleeytaelkriekeLKEIEEKErKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLK 513

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  315 EQCAQLTEQMETMKQKHSAELDEQNKKIQAMEQELASANDLLKQAREsnLESAICQLAPSAAVASRLIRS---------D 385
Cdd:PRK03918  514 KYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAE--LEKKLDELEEELAELLKELEElgfesveelE 591

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  386 LSLTELYSMYAK------SSEELEMRNCEIEQLKLQLKSIIAEISESAPILEKQNSDYQKMKETNSEllREHDELLQNKL 459
Cdd:PRK03918  592 ERLKELEPFYNEylelkdAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSE--EEYEELREEYL 669

                         490       500       510
                  ....*....|....*....|....*....|....
gi 442623382  460 CLERELERALSTLNHNQNENKKLKQTHTDLSRQV 493
Cdd:PRK03918  670 ELSRELAGLRAELEELEKRREEIKKTLEKLKEEL 703
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 17-516 1.92e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 56.67  E-value: 1.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    17 ELKLVPEDVQKKLSEYINNFSDEYCKNRAAANRLAEAEQKKEELENKMEDYLVKFTSfelNVNELRTHLDQMSSERVNLM 96
Cdd:pfam15921  300 QLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANS---ELTEARTERDQFSQESGNLD 376

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    97 DTIA-------KGEQTISqLRKEKASVVEERDSMMKV---------------IERQQAELERLKQDLHTYQQQLSSAIAA 154
Cdd:pfam15921  377 DQLQklladlhKREKELS-LEKEQNKRLWDRDTGNSItidhlrrelddrnmeVQRLEALLKAMKSECQGQMERQMAAIQG 455

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   155 KCEAIARVDEIQSKevalelkenrMESERDMLHKeillISGDLNKSNAELQNirREHTINtmQLQSCLKEKTESLKLMQE 234
Cdd:pfam15921  456 KNESLEKVSSLTAQ----------LESTKEMLRK----VVEELTAKKMTLES--SERTVS--DLTASLQEKERAIEATNA 517

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   235 QYEQAVKTIG-ELTSKIEMQNDTAFKQNQATEeyVGKLKKELDAKEKLFEIFKStesdhliQREELLQGISEIKRLLEEA 313
Cdd:pfam15921  518 EITKLRSRVDlKLQELQHLKNEGDHLRNVQTE--CEALKLQMAEKDKVIEILRQ-------QIENMTQLVGQHGRTAGAM 588

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   314 EEQCAQLT----------EQMETMKQKHSAELDEQNKKIQAMEQE----LASANDLLKQARESNLESAicQLAPSAAVAs 379
Cdd:pfam15921  589 QVEKAQLEkeindrrlelQEFKILKDKKDAKIRELEARVSDLELEkvklVNAGSERLRAVKDIKQERD--QLLNEVKTS- 665

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   380 rliRSDL-SLTELYSM----YAKSSEELEMRNceiEQLKLQLKSIIAEISESAPILEK-QNSDYQKMK-----ETNSELL 448
Cdd:pfam15921  666 ---RNELnSLSEDYEVlkrnFRNKSEEMETTT---NKLKMQLKSAQSELEQTRNTLKSmEGSDGHAMKvamgmQKQITAK 739

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442623382   449 REHDELLQNKLcleRELERALSTLNhnqNENKKLKQTHTDLSRQVCMLLDELNCIRAGVKHVRIQPTR 516
Cdd:pfam15921  740 RGQIDALQSKI---QFLEEAMTNAN---KEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERR 801
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 619-1475 2.20e-07

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 56.52  E-value: 2.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   619 QNTVDLDDSNLEPNDSALDTSEQPA-ANFEESRKLEKRVRQLEQQLEGEVKKYASLKENYDYYTSEKRKNDALAQEQFDS 697
Cdd:pfam02463  183 ENLAELIIDLEELKLQELKLKEQAKkALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEK 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   698 MRKEVRELTSSNCKLMNTTEFQKEQIELLHKNIGTYKQQVTTLEERTKNYEKTIIKHEQTVHLLKDEmmaahrkhaAADA 777
Cdd:pfam02463  263 EEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKE---------LKKE 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   778 EAQSLRQENRILRDTSSRLQIEKETYHREQQSQSLLLNSLEFIKTNLERSEMEGRQRLEQRLDDTVRELAAQRRHFQEEE 857
Cdd:pfam02463  334 KEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLEL 413

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   858 EKFRESINEFKRQAETAIKLKDEEKQLADKWQAELTSVREELAEKVNKVNELSKKLQEVLTPTLNDNPITAANKRAREfE 937
Cdd:pfam02463  414 ARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLS-R 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   938 LKLDQATVEIESLTKELAKTREHGEQFYKMsqsaeseikRLHELHGELVAKQEEEIKKLRSSEAELKTRISDLEAEAMLS 1017
Cdd:pfam02463  493 QKLEERSQKESKARSGLKVLLALIKDGVGG---------RIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEER 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1018 NVTEQSKTVNQSGQLKSAQDDLKSLLEKLTEANCTIRTLRSENTSLVESLNAAEVKYANGMIQHSADIQELTRYKaEFFK 1097
Cdd:pfam02463  564 QKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLK-ESAK 642

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1098 ANDELNQLKSGRESLQAAYDELLRSNAEAQKLLDKEREESEKRVADLHALNSNLHDQIEALASKLAVLASQSQN---PNS 1174
Cdd:pfam02463  643 AKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKleaEEL 722

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1175 SLNESAMDGDQSLNASGLTAAEEGRNNEQLLKIIKFLRKEKDLFAAKLDILK--AENARLISEHAIQQKKVDELNGYLNQ 1252
Cdd:pfam02463  723 LADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKelAEEREKTEKLKVEEEKEEKLKAQEEE 802

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1253 ERAKSQTDVVSANKHEEVLRKIETLNAITDS-NRILREERNALTLRVAELTDRISSVEKELFPLQCSNKELTSKIEEINV 1331
Cdd:pfam02463  803 LRALEEELKEEAELLEEEQLLIEQEEKIKEEeLEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQ 882

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1332 ENTSLRTEAIKwrqranALVEKSNRNPEEFKRLQAEREHLAKLLTAEKELNKKQSDELTVLKQRMNTEIPMLNKQMQILD 1411
Cdd:pfam02463  883 KLKDELESKEE------KEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKE 956

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442623382  1412 EARKKQVDEFTNLKQNNTRQTQDIMELKNRLLQKEEELLKANEELETKDKTIADKETKELQLRK 1475
Cdd:pfam02463  957 EEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQRLK 1020
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 265-1121 2.26e-07

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 56.52  E-value: 2.26e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   265 EEYVGKLKKELDAKEKLFEIFKSTESDHLIQREELLQGISEIKRLLEEAEEQcaqltEQMETMKQKHSAELDEQNKKIQA 344
Cdd:pfam02463  159 EEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKAL-----EYYQLKEKLELEEEYLLYLDYLK 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   345 MEQELASANDLLKQARESNLESAICQLapsaavasrlirsdlsltelysmyAKSSEELEMRNCEIEQLKLQLKSIIAEIS 424
Cdd:pfam02463  234 LNEERIDLLQELLRDEQEEIESSKQEI------------------------EKEEEKLAQVLKENKEEEKEKKLQEEELK 289

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   425 ESAPILEKQNSDYQKMKETNSELLREHDELLQNKLCLERELERALSTLNHNQNENKKL---KQTHTDLSRQVCMLLDELN 501
Cdd:pfam02463  290 LLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELeikREAEEEEEEELEKLQEKLE 369

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   502 CIRAGVKHVRIQPTRQLPTSESLISDNLVTFSSIEELVDRNTYLLNMSRELTELLEASEKNQDKMLLEQsknhIRKLDAR 581
Cdd:pfam02463  370 QLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEES----IELKQGK 445

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   582 FAELEDLLTQKNNTVTTLLSKCDRYKKLYFAAQKKLGQNT-VDLDDSNLEPNDSALDTSEQPAANFEESRKLEKRVRQLe 660
Cdd:pfam02463  446 LTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQlELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRI- 524

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   661 QQLEGEVKKYASLKENYDYYTSEKRKNDALAQEQFDSMRKEVRELTSSNCKLMNTTEFQKEQIELLHKNIGTY------- 733
Cdd:pfam02463  525 ISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLeidpiln 604

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   734 ---KQQVTTLEERTKNYEKTIIKHEQTvHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQ 810
Cdd:pfam02463  605 laqLDKATLEADEDDKRAKVVEGILKD-TELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQE 683

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   811 --SLLLNSLEFIKTNLERSEMEGRQRLEQR--LDDTVRELAAQRRHFQEEEEKFRESINEFKRQAETAIKLKDEEKQLAD 886
Cdd:pfam02463  684 kaESELAKEEILRRQLEIKKKEQREKEELKklKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKE 763

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   887 KWQAELTSVREELAEKVNKVNELSKKLQEVLTPTLNDNPITAANKRAREFELKLDQATVEIESLTKELAKTREHGEQFYK 966
Cdd:pfam02463  764 EEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELK 843

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   967 MSQ----SAESEIKRLHELHGELVAKQEEEIKKLRSSEAELKTRISDLEAEAMLSN---VTEQSKTVNQSGQLKSAQDDL 1039
Cdd:pfam02463  844 EEQklekLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKkelEEESQKLNLLEEKENEIEERI 923

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1040 KSLLEKLTEANCTIRTLRSENTSLVESLNAAEVKYANGMIQHSADIQELTR----YKAEFFKANDELNQLKSGRESLQAA 1115
Cdd:pfam02463  924 KEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKvnlmAIEEFEEKEERYNKDELEKERLEEE 1003


                   ....*.
gi 442623382  1116 YDELLR 1121
Cdd:pfam02463 1004 KKKLIR 1009
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 52-362 2.34e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.48  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   52 EAEQKKE--ELENKMEDYLVKFTSFELNvnELRTHLDQMSSERVNLMDTIAKGEQTISQLRKEKASVVEERDSMMKVIER 129
Cdd:COG1196   208 QAEKAERyrELKEELKELEAELLLLKLR--ELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEE 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  130 QQAELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELKENRMESERDMLHKEILLISGDLNKSNAELQNIRR 209
Cdd:COG1196   286 AQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEE 365

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  210 EhtintmqlqscLKEKTESLKLMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQATEEYVGKLKKELDAKEKLfeifKSTE 289
Cdd:COG1196   366 A-----------LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEEL----EEAL 430

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442623382  290 SDHLIQREELLQGISEIKRLLEEAEEQCAQLTEQMETmKQKHSAELDEQNKKIQAMEQELASANDLLKQARES 362
Cdd:COG1196   431 AELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAE-LLEEAALLEAALAELLEELAEAAARLLLLLEAEAD 502
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 837-1530 2.46e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 56.52  E-value: 2.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   837 QRLDDTVRELAAQRRHFQEEEEKFRESINEFKRQaetaiklkDEEKQLADKWQAELTSVREELAEKVNKVNELSkKLQEV 916
Cdd:TIGR00618  215 DTYHERKQVLEKELKHLREALQQTQQSHAYLTQK--------REAQEEQLKKQQLLKQLRARIEELRAQEAVLE-ETQER 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   917 LTPTLNDNPITAANKRAREFELKLDQATVEIESLTKELAKTREHGEQFYKMSQSAESEIKRLHELHgelvaKQEEEIKKL 996
Cdd:TIGR00618  286 INRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLH-----SQEIHIRDA 360

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   997 RSSEAELKTRISDLEAEAMLSNVTEQSKTVnqsgqLKSAQDDLKSLLEKLTEANCTIRTLRSENTSLVESLNAAEvkyan 1076
Cdd:TIGR00618  361 HEVATSIREISCQQHTLTQHIHTLQQQKTT-----LTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAK----- 430

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1077 GMIQHSADIQELTRYKAEffKANDELNQLKSGRESLQAAYDELLRSNAEAQKLLDKEREESEKRVADLHALNSNlHDQIE 1156
Cdd:TIGR00618  431 KQQELQQRYAELCAAAIT--CTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEE-PCPLC 507

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1157 ALASKLAVLASQSQNP--NSSLNESAMDGDQSLNASGLTAAEEGrnnEQLLKIIKFLRKEKDLFAAKLDILKAENARLIS 1234
Cdd:TIGR00618  508 GSCIHPNPARQDIDNPgpLTRRMQRGEQTYAQLETSEEDVYHQL---TSERKQRASLKEQMQEIQQSFSILTQCDNRSKE 584

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1235 EHAIQQKKVDELNGYLNQEraksqtdvvsaNKHEEVLRkietlnaiTDSNRILREERNALTLRVAELTDRISSVEKELFP 1314
Cdd:TIGR00618  585 DIPNLQNITVRLQDLTEKL-----------SEAEDMLA--------CEQHALLRKLQPEQDLQDVRLHLQQCSQELALKL 645

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1315 LQCSNKELTSKIEEINVENTSLRT-EAIKWRQRANALVEKSNRN-------PEEFKRLQAEREHLAKLLTAEKELNkKQS 1386
Cdd:TIGR00618  646 TALHALQLTLTQERVREHALSIRVlPKELLASRQLALQKMQSEKeqltywkEMLAQCQTLLRELETHIEEYDREFN-EIE 724

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1387 DELTVLKQRMNTEIPMLNKQMQILDEARKKQVDEFTNLKQNNTRQTQDIMELKNRLLQKEEELLKANEELETKDKTIADK 1466
Cdd:TIGR00618  725 NASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTL 804

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442623382  1467 ET------------KELQLRKLAKRYKDFYIGLQSQGggtESAAELEKVRSELEEVNNQLRALKDEHEKITKECDE 1530
Cdd:TIGR00618  805 EAeigqeipsdediLNLQCETLVQEEEQFLSRLEEKS---ATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDK 877
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 23-846 2.74e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 56.28  E-value: 2.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    23 EDVQKKLSEYINNFSDeycknraAANRLAEAEqkkeELENKMEDYLVKftsfelNVNELRTHLDQMSSERVNLMDTIAKG 102
Cdd:pfam15921   74 EHIERVLEEYSHQVKD-------LQRRLNESN----ELHEKQKFYLRQ------SVIDLQTKLQEMQMERDAMADIRRRE 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   103 EQTISQLRKEKASVVEErdsmmkvIERQQAELERLKQDLHTYQQQLSSAIAAKcEAIarVDEIQSKEVALELKENRMESE 182
Cdd:pfam15921  137 SQSQEDLRNQLQNTVHE-------LEAAKCLKEDMLEDSNTQIEQLRKMMLSH-EGV--LQEIRSILVDFEEASGKKIYE 206

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   183 RD---MLHKEIL--LISGDLNKSNAELQNIRREHTINTMQLQSCLKEKTESLKLMQEQYEQAVKtigELTSKIEMQNDTA 257
Cdd:pfam15921  207 HDsmsTMHFRSLgsAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIE---QLISEHEVEITGL 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   258 FKQNQATEEYVGKLKKELdakEKLFEIFKSTESDHLIQREELLQGISEIKRLLEEAEEQCAQLTEQMETMKQKHSAELDE 337
Cdd:pfam15921  284 TEKASSARSQANSIQSQL---EIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTE 360

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   338 QNKKIQAMEQELASANDLLkQARESNLESAICQLAPSAAVASRLIRSDLSLTELYSMYAKsseELEMRNCEIEQLKLQLK 417
Cdd:pfam15921  361 ARTERDQFSQESGNLDDQL-QKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRR---ELDDRNMEVQRLEALLK 436

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   418 SI-----------IAEISESAPILEKQNSDYQKMKETNSELLREHDELLQNKLCLERElERALSTLNHN-QNENKKLKQT 485
Cdd:pfam15921  437 AMksecqgqmerqMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESS-ERTVSDLTASlQEKERAIEAT 515

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   486 HTDLSR---QVCMLLDELNCIRAGVKHVRIQPTR------QLPTSESLISDNLVTFSSIEELVDRNTYLLNMSRELTELL 556
Cdd:pfam15921  516 NAEITKlrsRVDLKLQELQHLKNEGDHLRNVQTEcealklQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQL 595

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   557 EaSEKNQDKMLLEQSKNHIRKLDARFAELEdlltqknntvttllskcdrykklyfAAQKKLGQNTVDLDDSNLEPNDSAL 636
Cdd:pfam15921  596 E-KEINDRRLELQEFKILKDKKDAKIRELE-------------------------ARVSDLELEKVKLVNAGSERLRAVK 649

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   637 DTSEqpaanfeESRKLEKRVRQLEQQLEGEVKKYASLKENYDYYTSEKRKNDALAQEQFDSMRKEVrELTSSNCKLMNTT 716
Cdd:pfam15921  650 DIKQ-------ERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSEL-EQTRNTLKSMEGS 721

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   717 EFQKEQIEL-LHKNIGTYKQQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSSR 795
Cdd:pfam15921  722 DGHAMKVAMgMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERR 801

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....
gi 442623382   796 LQiEKETyhreQQSQSLLLNSLEFIKTN--LERSEMEG-RQRLEQRLDdtVREL 846
Cdd:pfam15921  802 LK-EKVA----NMEVALDKASLQFAECQdiIQRQEQESvRLKLQHTLD--VKEL 848
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1086-1555 2.82e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 56.23  E-value: 2.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1086 QELTRYKAEFFKANDELNQLKSGRESLQAAYDELlRSNAEAQKLLDKEREESEKRVADLHALNSNLHDQIEALASKLAVL 1165
Cdd:PRK03918  200 KELEEVLREINEISSELPELREELEKLEKEVKEL-EELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEEL 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1166 ASQSQNPNSsLNESAmdgdqslnasgltaaeegrnnEQLLKIIKFLRKEKDlfaaKLDILKAENARLISEHAIQQKKVDE 1245
Cdd:PRK03918  279 EEKVKELKE-LKEKA---------------------EEYIKLSEFYEEYLD----ELREIEKRLSRLEEEINGIEERIKE 332

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1246 LNgylNQERAKSQTDvvsaNKHEEVLRKIETLNA---ITDSNRILREERNALTLRVAELTdrISSVEKELFPLQCSNKEL 1322
Cdd:PRK03918  333 LE---EKEERLEELK----KKLKELEKRLEELEErheLYEEAKAKKEELERLKKRLTGLT--PEKLEKELEELEKAKEEI 403

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1323 TSKIEEINVENTSLRTEAIKWRQRANALVEKSNRNP------EEFKRLQAEREHLAKLLTAEKELNKKQSDELTVLKQRM 1396
Cdd:PRK03918  404 EEEISKITARIGELKKEIKELKKAIEELKKAKGKCPvcgrelTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELR 483

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1397 NTEI-----PMLNKQMQILDEAR--KKQVDEFTnlKQNNTRQTQDIMELKNRLLQKEEELLKANEELETKDKTIADKETK 1469
Cdd:PRK03918  484 ELEKvlkkeSELIKLKELAEQLKelEEKLKKYN--LEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAEL 561

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1470 ELQLRKLAKRYKDFYIGLQSQGggTESAAELEKVRSELEEVNNQLRALKDEHEKITKECDEVKKRTEPETDTSAIRQEYK 1549
Cdd:PRK03918  562 EKKLDELEEELAELLKELEELG--FESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETE 639


                  ....*.
gi 442623382 1550 AKLDKL 1555
Cdd:PRK03918  640 KRLEEL 645
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 49-373 3.81e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 55.84  E-value: 3.81e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    49 RLAEAEQKKEELENKMEDYLVKftsfelnVNELRTHLDQMSSErvnlmdtIAKGEQTISQLRKEKASVVEERdsmmkviE 128
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSE-------LRRIENRLDELSQE-------LSDASRKIGEIEKEIEQLEQEE-------E 733

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   129 RQQAELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELKENrmESERDMLHKEIllisgdlNKSNAELQNIR 208
Cdd:TIGR02169  734 KLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALN--DLEARLSHSRI-------PEIQAELSKLE 804

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   209 REHTINTMQLQScLKEKTESLKLMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQATEEYVGKLKKELDAKEKLFEIFKST 288
Cdd:TIGR02169  805 EEVSRIEARLRE-IEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESR 883

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   289 ESDHLIQREELLQGISEIKRLLEEAEEQCAQLTEQMETMKQKHSA------ELDEQNKKIQAMEQELASANDLLKQAREs 362
Cdd:TIGR02169  884 LGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEAleeelsEIEDPKGEDEEIPEEELSLEDVQAELQR- 962

                          330
                   ....*....|.
gi 442623382   363 nLESAICQLAP 373
Cdd:TIGR02169  963 -VEEEIRALEP 972
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 229-489 9.19e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.56  E-value: 9.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  229 LKLMQEQYEQAVKTIGELTSKIEMQNdtafKQNQATEEYVGKLKKELDAKEKLFEIFKSTESDHLIQREELLQGISEIKR 308
Cdd:COG1196   234 LRELEAELEELEAELEELEAELEELE----AELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEE 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  309 LLEEAEEQCAQLTEQMETMKQK---HSAELDEQNKKIQAMEQELASANDLLKQARESNLESAIcQLAPSAAVASRLIRSD 385
Cdd:COG1196   310 RRRELEERLEELEEELAELEEEleeLEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA-ELAEAEEELEELAEEL 388

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  386 LSLTELYSMYAKSSEELEMR----NCEIEQLKLQLKSIIAEISESAPILEKQNSDYQKMKETNSELLREHDELLQNKLCL 461
Cdd:COG1196   389 LEALRAAAELAAQLEELEEAeealLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAEL 468

                         250       260
                  ....*....|....*....|....*...
gi 442623382  462 ERELERALSTLNHNQNENKKLKQTHTDL 489
Cdd:COG1196   469 LEEAALLEAALAELLEELAEAAARLLLL 496
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 987-1630 1.29e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 53.91  E-value: 1.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   987 AKQEEEIKKLRSSEAELKtRISDL--EAEAMLSNVTEQSKTVNQ----SGQLKSAQ-----DDLKSLLEKLTEANCTIRT 1055
Cdd:TIGR02168  172 ERRKETERKLERTRENLD-RLEDIlnELERQLKSLERQAEKAERykelKAELRELElallvLRLEELREELEELQEELKE 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1056 LRSENTSLVESLNAAEVKYANGMIQHSADIQELTRYKAEFFKANDELN----QLKSGRESLQAAYDELLRSNAEAQKLlD 1131
Cdd:TIGR02168  251 AEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISrleqQKQILRERLANLERQLEELEAQLEEL-E 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1132 KEREESEKRVADLHALNSNLHDQIEALASKLAVLASQSQNPNSSLNEsamdgdqslnasgLTAAEEGRNNE--QLLKIIK 1209
Cdd:TIGR02168  330 SKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEE-------------LEEQLETLRSKvaQLELQIA 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1210 FLRKEKDLFAAKLDILKAENARLISEHAIQQKKVDELNGYLNQERAkSQTDVVSANKHEEVLRKIETLNAITDSNRILRE 1289
Cdd:TIGR02168  397 SLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAEL-EELEEELEELQEELERLEEALEELREELEEAEQ 475

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1290 ERNALTLRVAELTDRISSVEK---ELFPLQCSNKELTSKIEEIN----VENTSLRTEAiKWRQ--------RANALVekS 1354
Cdd:TIGR02168  476 ALDAAERELAQLQARLDSLERlqeNLEGFSEGVKALLKNQSGLSgilgVLSELISVDE-GYEAaieaalggRLQAVV--V 552

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1355 NRNPEEFKRLQAEREHLAKLLTAeKELNKKQSDELTVLKQRMNTEIPMLNKQMQILDEARKKQVDEFTNLkQNNTRQTQD 1434
Cdd:TIGR02168  553 ENLNAAKKAIAFLKQNELGRVTF-LPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYL-LGGVLVVDD 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1435 I---MELKnRLLQKEEELLKANEELETKDKTIADKETKELQ--------LRKLAKRYKdfyiglQSQGGGTESAAELEKV 1503
Cdd:TIGR02168  631 LdnaLELA-KKLRPGYRIVTLDGDLVRPGGVITGGSAKTNSsilerrreIEELEEKIE------ELEEKIAELEKALAEL 703

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1504 RSELEEVNNQLRALKDEHEKITKECDEVKKRTEPETDTSAIRQEYKAKLDKLVVDLTVARTDLVNQETTFAGTKSSYDET 1583
Cdd:TIGR02168  704 RKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 442623382  1584 IARLEKELQENIAANKDINQRLtrenESLHMRINQLTRQLGSQQSTK 1630
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREAL----DELRAELTLLNEEAANLRERL 826
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 293-985 3.88e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 52.28  E-value: 3.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   293 LIQREELLQGISEIKRLLEEAEEQCAQLTEQMETMKQKHSAELDEQNKKIQAMEQELASANDLLKQARES-----NLESA 367
Cdd:TIGR00618  172 LFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQShayltQKREA 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   368 ICQLAPSAAVASRLIRSDLSLTELYSMYAKSSEELEMR---------NCEIEQLKLQLKSIIAEISESAPILEK---QNS 435
Cdd:TIGR00618  252 QEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRArkaaplaahIKAVTQIEQQAQRIHTELQSKMRSRAKllmKRA 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   436 DYQKMKETNSELLREHDELLQNKLCLERELERALSTLNHNQNENKKLKQTHTdLSRQVCMLLDELNCIRAGVKHVRIQPT 515
Cdd:TIGR00618  332 AHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHT-LQQQKTTLTQKLQSLCKELDILQREQA 410

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   516 RQLP--TSESLISDNLVTFSSIEELvdrntyllnmSRELTELLEASEKNQDKMlLEQSKNHIRKLDARFAELEDLLTQKN 593
Cdd:TIGR00618  411 TIDTrtSAFRDLQGQLAHAKKQQEL----------QQRYAELCAAAITCTAQC-EKLEKIHLQESAQSLKEREQQLQTKE 479

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   594 NtvttLLSKCDRYKKLYFAAQKKLGQNTVDLDDSNLEPNDSALDTSEQPA------ANFEESRKLEKRVRQLEQQLEGEV 667
Cdd:TIGR00618  480 Q----IHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPltrrmqRGEQTYAQLETSEEDVYHQLTSER 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   668 KKYASLKENydyYTSEKRKNDALAQeQFDSMRKEVRELTSSNCKLMNTTEFQKE---------QIELLHKNIGTYKQQVt 738
Cdd:TIGR00618  556 KQRASLKEQ---MQEIQQSFSILTQ-CDNRSKEDIPNLQNITVRLQDLTEKLSEaedmlaceqHALLRKLQPEQDLQDV- 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   739 TLEERTKNYE---KTIIKHEQTVHLLKDEMmaahRKHAAADAEAQSLRQENRILRDTSSRLQIEKETYHRE--QQSQSLL 813
Cdd:TIGR00618  631 RLHLQQCSQElalKLTALHALQLTLTQERV----REHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEmlAQCQTLL 706

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   814 LNSLEFIKTN------LERSEMEGRQRLEQRlDDTVRELAAQRRHFQEEEEKFRESINEFKRQAETA-IKLKDEEKQLAd 886
Cdd:TIGR00618  707 RELETHIEEYdrefneIENASSSLGSDLAAR-EDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAaLQTGAELSHLA- 784

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   887 kwqAELTSVREELAEKVNKVNELSKKLQEVLtPTLNDNPITAANKRAREFElKLDQATVEIESLTKELAKTREHGEQFYK 966
Cdd:TIGR00618  785 ---AEIQFFNRLREEDTHLLKTLEAEIGQEI-PSDEDILNLQCETLVQEEE-QFLSRLEEKSATLGEITHQLLKYEECSK 859

                          730
                   ....*....|....*....
gi 442623382   967 MSQSAESEIKRLHELHGEL 985
Cdd:TIGR00618  860 QLAQLTQEQAKIIQLSDKL 878
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 259-472 4.24e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.69  E-value: 4.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  259 KQNQATEEYVGKLKKELDAKEKLFEIFKSTESDHLIQREELLQGISEIKRLLEEAEEQCAQLTEQMETMKQkhsaELDEQ 338
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEK----EIAEL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  339 NKKIQAMEQELASANDLL-KQARESNLE-----SAICQLAPSAAVASRLIRSDLSLTElysMYAKSSEELEMRNCEIEQL 412
Cdd:COG4942    96 RAELEAQKEELAELLRALyRLGRQPPLAlllspEDFLDAVRRLQYLKYLAPARREQAE---ELRADLAELAALRAELEAE 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  413 KLQLKSIIAEISESAPILEKQNSDYQKMKETNSELLREHDELLQNKLCLERELERALSTL 472
Cdd:COG4942   173 RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARL 232
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1288-1607 4.93e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 51.99  E-value: 4.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1288 REERNALTLRVAELTDRISSVEKELFPLQCSNKELTSKIEEINVENTSLRTEAIKWRQRANALVEKSNRNPEEFKRLQAE 1367
Cdd:PRK03918  178 IERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1368 REHLAKLLTAEKELnKKQSDELTVLKQRMNtEIPMLNKQMQILDEARKKQVDEFTNLKQNNTRQTQDIMELKNR------ 1441
Cdd:PRK03918  258 EEKIRELEERIEEL-KKEIEELEEKVKELK-ELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERikelee 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1442 -------LLQKEEELLKANEELETKDKTIADKETKELQLRKLAKRYKDFyiglqsqgggtesaaELEKVRSELEEVNNQL 1514
Cdd:PRK03918  336 keerleeLKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGL---------------TPEKLEKELEELEKAK 400

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1515 RALKDEHEKITKECDEVKKRtepetdtSAIRQEYKAKLDKLVVDLTVARTDLVNQETtfAGTKSSYDETIARLEKELQEN 1594
Cdd:PRK03918  401 EEIEEEISKITARIGELKKE-------IKELKKAIEELKKAKGKCPVCGRELTEEHR--KELLEEYTAELKRIEKELKEI 471

                         330
                  ....*....|...
gi 442623382 1595 IAANKDINQRLTR 1607
Cdd:PRK03918  472 EEKERKLRKELRE 484
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 988-1613 5.68e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 51.94  E-value: 5.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   988 KQEEEIKKLRSSEAELKTRisDLEAEAMLSNVTEQSKTVNQSG-QLKSAQDDLKSLLEKLTEANCTIRTLRSENTSLVES 1066
Cdd:TIGR04523   34 EEKQLEKKLKTIKNELKNK--EKELKNLDKNLNKDEEKINNSNnKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1067 LNAAEVKYANGMIQHSADIQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSNAEaqklLDKEREESEKRVADLHA 1146
Cdd:TIGR04523  112 IKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEE----LENELNLLEKEKLNIQK 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1147 LNSNLHDQIEALASKLAVLASQSQ-------------NPNSSLNESAMDGDQSLNAsglTAAEEGRNNEQLLKIIKFLRK 1213
Cdd:TIGR04523  188 NIDKIKNKLLKLELLLSNLKKKIQknkslesqiselkKQNNQLKDNIEKKQQEINE---KTTEISNTQTQLNQLKDEQNK 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1214 EKDLFAAKLDILKAENARLIS-EHAIQQKKVDELNgyLNQERAKSQTDVVSANKHEEVLRKIETLNAITDSNRIlreern 1292
Cdd:TIGR04523  265 IKKQLSEKQKELEQNNKKIKElEKQLNQLKSEISD--LNNQKEQDWNKELKSELKNQEKKLEEIQNQISQNNKI------ 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1293 altlrVAELTDRISSVEKELFPLQCSNKELT-------SKIEEINVENTSLRTEAIKWRQRANALveksNRNPEEFKRLQ 1365
Cdd:TIGR04523  337 -----ISQLNEQISQLKKELTNSESENSEKQreleekqNEIEKLKKENQSYKQEIKNLESQINDL----ESKIQNQEKLN 407

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1366 AEREHLAKLLTAEKELNKKQSDELTVLKQRMNTEIPMLNKQMQILDEARKKQVDEFTNLKQNNTRQTQDIMELKNRLLQK 1445
Cdd:TIGR04523  408 QQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQK 487

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1446 EEELLKANEELE--TKDKTIADKETKELQLRKlakrykdfyiglqsqgggTESAAELEKVRSELEEVNNQLRALKDEHEK 1523
Cdd:TIGR04523  488 QKELKSKEKELKklNEEKKELEEKVKDLTKKI------------------SSLKEKIEKLESEKKEKESKISDLEDELNK 549

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1524 ItkecDEVKKRTEPETDTSAIRQEYK-------------AKLDKLVVDLTVARTDLVNQETTfagtkssYDETIARLEKE 1590
Cdd:TIGR04523  550 D----DFELKKENLEKEIDEKNKEIEelkqtqkslkkkqEEKQELIDQKEKEKKDLIKEIEE-------KEKKISSLEKE 618

                          650       660
                   ....*....|....*....|...
gi 442623382  1591 LQENIAANKDINQRLTRENESLH 1613
Cdd:TIGR04523  619 LEKAKKENEKLSSIIKNIKSKKN 641
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 47-737 7.16e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 51.61  E-value: 7.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    47 ANRLAEAEQKKEELENKMEDylvkftSFELNVNELRTHLDQMSSERVNLMDTIAKGEQTISQLRKEKASVVEERDSMM-- 124
Cdd:TIGR02169  264 EKRLEEIEQLLEELNKKIKD------LGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLae 337

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   125 -----KVIERQQ-------AELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELKENRMESERDMLHKEILL 192
Cdd:TIGR02169  338 ieeleREIEEERkrrdkltEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQR 417

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   193 ISGDLNKSNAELQNIRREHTintmQLQSCLKEKTESLKLMQEQYEQAVKTIGELTSKIEmqnDTAFKQNQATEEyVGKLK 272
Cdd:TIGR02169  418 LSEELADLNAAIAGIEAKIN----ELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELY---DLKEEYDRVEKE-LSKLQ 489

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   273 KELDAKEKLFEIFKSTESDHLIQREELLQGISEIKRLL-----------------------------EEAEEQCAQLTEQ 323
Cdd:TIGR02169  490 RELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVaqlgsvgeryataievaagnrlnnvvvedDAVAKEAIELLKR 569

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   324 MET----------MKQKHS-----------------AELDEQNKKIQA-------MEQELASANDLLKQARESNLESAIc 369
Cdd:TIGR02169  570 RKAgratflplnkMRDERRdlsilsedgvigfavdlVEFDPKYEPAFKyvfgdtlVVEDIEAARRLMGKYRMVTLEGEL- 648

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   370 qLAPSAAVASrlirSDLSLTELYSMYAKSSEELEMRNCEIEQLKLQLKSIIAEISESAPILEKQNSDYQKMKETNSELLR 449
Cdd:TIGR02169  649 -FEKSGAMTG----GSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEK 723

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   450 EHDELLQNKLCLERELERALSTLNHNQNE--NKKLKQTH-----TDLSRQVCMLLDELNCIRAGVKHVRIQP-TRQLPTS 521
Cdd:TIGR02169  724 EIEQLEQEEEKLKERLEELEEDLSSLEQEieNVKSELKEleariEELEEDLHKLEEALNDLEARLSHSRIPEiQAELSKL 803

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   522 ESLISDNLVTFSSIEELVDRNTYLLNMSRELTELLEA------SEKNQDKMLLEQSKNHIRKLDARFAELEDLLTQKNNT 595
Cdd:TIGR02169  804 EEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEqridlkEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESR 883

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   596 VTTLLSKCDRYKKLYFAAQKKLGQNTVDLDDSnlepNDSALDTSEQPAANFEESRKLEKRVRQLEQQLEgEVKKYASLKE 675
Cdd:TIGR02169  884 LGDLKKERDELEAQLRELERKIEELEAQIEKK----RKRLSELKAKLEALEEELSEIEDPKGEDEEIPE-EELSLEDVQA 958

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442623382   676 NYDYYTSEKRK---NDALAQEQFDSMRKEVRELTSSNCKLMNttefQKEQIELLHKNIGTYKQQV 737
Cdd:TIGR02169  959 ELQRVEEEIRAlepVNMLAIQEYEEVLKRLDELKEKRAKLEE----ERKAILERIEEYEKKKREV 1019
PHA03169 PHA03169
hypothetical protein; Provisional
 2117-2267 8.68e-06

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 50.74  E-value: 8.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2117 ESAEVDGTAEVAGGAPHESAGPSDTGA----ASASSPQK---QSEAGESSGSDALKAADDGGDHADGTDNAREADEAFAE 2189
Cdd:PHA03169   84 KEERGQGGPSGSGSESVGSPTPSPSGSaeelASGLSPENtsgSSPESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQP 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2190 ETMATGQGEDsqplGNDNPNVGTSQSEVSHNQANLGEgNPTEDSEGADGVSSEGEKQAVGVEE--EGREAEATS----PS 2263
Cdd:PHA03169  164 SSFLQPSHED----SPEEPEPPTSEPEPDSPGPPQSE-TPTSSPPPQSPPDEPGEPQSPTPQQapSPNTQQAVEhedePT 238


                  ....
gi 442623382 2264 ENTR 2267
Cdd:PHA03169  239 EPER 242
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
836-1416 1.49e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 50.45  E-value: 1.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  836 EQRLDDTVRELAAQRRHFQEEEEKFRESINEFKRQAETAIKLKDEEKQLAD------KWQAELTSVREELAEKVNKVNEL 909
Cdd:PRK03918  199 EKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESlegskrKLEEKIRELEERIEELKKEIEEL 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  910 SKKLQEVltptlndNPITAANKRAREFELKLDQATVEIESLTKELAKTREHGEQFYKMSQSAESEIKRLHELhgelvakq 989
Cdd:PRK03918  279 EEKVKEL-------KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEEL-------- 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  990 EEEIKKLRSSEAELKTRISDLE-AEAMLSNVTEQSK--TVNQSGQLKSAQDDLKSLLEKLTEANCTIRTLRSENTSLVES 1066
Cdd:PRK03918  344 KKKLKELEKRLEELEERHELYEeAKAKKEELERLKKrlTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKE 423

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1067 LNAA--EVKYANGMI---------QHSADIqeLTRYKAeffkandELNQLKSGRESLQAAYDELLRSNAEAQKLLDKERE 1135
Cdd:PRK03918  424 LKKAieELKKAKGKCpvcgrelteEHRKEL--LEEYTA-------ELKRIEKELKEIEEKERKLRKELRELEKVLKKESE 494

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1136 ESEKRvadlhalnsNLHDQIEALASKLAVLASQSQNPNSSLNEsamdgdqSLNASGLTAAEEGRNNEQLLKIIKFLRKEK 1215
Cdd:PRK03918  495 LIKLK---------ELAEQLKELEEKLKKYNLEELEKKAEEYE-------KLKEKLIKLKGEIKSLKKELEKLEELKKKL 558

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1216 DLFAAKLDILKAENARLISE-HAIQQKKVDELNGYLNQeraksqtdvvsankHEEVLRKIETLNAITDSNRILREERNAL 1294
Cdd:PRK03918  559 AELEKKLDELEEELAELLKElEELGFESVEELEERLKE--------------LEPFYNEYLELKDAEKELEREEKELKKL 624

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1295 TLRVAELTDRISSVEKELfplqcsnKELTSKIEEINVENTSLRTEAIKwrqraNALVEKSNrnpeEFKRLQAEREHLAKL 1374
Cdd:PRK03918  625 EEELDKAFEELAETEKRL-------EELRKELEELEKKYSEEEYEELR-----EEYLELSR----ELAGLRAELEELEKR 688

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 442623382 1375 L-TAEKELNKKQSDELTVLKQRMntEIPMLNKQMQILDEARKK 1416
Cdd:PRK03918  689 ReEIKKTLEKLKEELEEREKAKK--ELEKLEKALERVEELREK 729
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 406-1048 1.53e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 50.40  E-value: 1.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   406 NCEIEQLKLQLKSIIAEISESAPILEKQNSDYQKMKE----------------TNSELLREHDELLQNKLCLE-RELERA 468
Cdd:TIGR04523   74 NNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSeikndkeqknklevelNKLEKQKKENKKNIDKFLTEiKKKEKE 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   469 LSTLNHNQNENKKLKQthtDLSRQVCMLLDELNCIRAGVKHVRIQPTRQLptseslisdnlVTFSSIEELVDRNTYLlnm 548
Cdd:TIGR04523  154 LEKLNNKYNDLKKQKE---ELENELNLLEKEKLNIQKNIDKIKNKLLKLE-----------LLLSNLKKKIQKNKSL--- 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   549 SRELTELleaseKNQDKMLleqsKNHIRKLDARFAELEDLLTQKNNTVTTLLSKCDRYKKLYFAAQKKLGQNTVDLDDSN 628
Cdd:TIGR04523  217 ESQISEL-----KKQNNQL----KDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELE 287

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   629 LEPND---SALDTSEQPAANF-----EESRKLEKRVRQLEQQLEGEVKKYASLKEnydyytsekrkndalaqeQFDSMRK 700
Cdd:TIGR04523  288 KQLNQlksEISDLNNQKEQDWnkelkSELKNQEKKLEEIQNQISQNNKIISQLNE------------------QISQLKK 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   701 EVRELTSSNCKLMNTTEFQKEQIELLHKNIGTYKQQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQ 780
Cdd:TIGR04523  350 ELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIE 429

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   781 SLRQENRILRDTSSRLQIEKetyhreqqsqslllNSLEFIKTNLERSemegrqrleqrlddtvrelaaqRRHFQEEEEKF 860
Cdd:TIGR04523  430 RLKETIIKNNSEIKDLTNQD--------------SVKELIIKNLDNT----------------------RESLETQLKVL 473

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   861 RESINEFKRqaetaiKLKDEEKQLADKWQaELTSVREELAEKVNKVNELSKKLQEVLtptlndNPITAANKRAREFELKL 940
Cdd:TIGR04523  474 SRSINKIKQ------NLEQKQKELKSKEK-ELKKLNEEKKELEEKVKDLTKKISSLK------EKIEKLESEKKEKESKI 540

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   941 DQATVEIESLTKELAKtrehgEQFYKMSQSAESEIKRLHELHGELVAKQEEEIKKLRSSEAELKTRISDLEA-EAMLSNV 1019
Cdd:TIGR04523  541 SDLEDELNKDDFELKK-----ENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEkEKKISSL 615

                          650       660       670
                   ....*....|....*....|....*....|
gi 442623382  1020 TEQSKTVN-QSGQLKSAQDDLKSLLEKLTE 1048
Cdd:TIGR04523  616 EKELEKAKkENEKLSSIIKNIKSKKNKLKQ 645
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 408-1011 2.38e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 49.63  E-value: 2.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   408 EIEQLKLQLKSIIAEISESAPILEKQNSDYQKMKETNSELLREHDELLQNKLCLE----------RELERALSTLNHNQN 477
Cdd:TIGR04523  132 QKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQknidkiknklLKLELLLSNLKKKIQ 211

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   478 ENKKL-------KQTHTDLSRQVCMLLDELNCIRAGVKHVRIQPTRqlpTSESLISDNLVTFSSIEELVDRNTYLLNMSR 550
Cdd:TIGR04523  212 KNKSLesqiselKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQ---LKDEQNKIKKQLSEKQKELEQNNKKIKELEK 288

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   551 ELTEL---LEASEKNQDKMLLEQSKNHIRKLDARFAELEDLLTQKNNTVTTLLSKCDRYKKlyfaaQKKLGQNTVDLDDS 627
Cdd:TIGR04523  289 QLNQLkseISDLNNQKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKK-----ELTNSESENSEKQR 363

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   628 NLEPNDSALDT-SEQPAANFEESRKLEKRVRQLEQQLEgevkkyaslkeNYDYYTSEKRKNDALAQEQFDSMRKEVRELT 706
Cdd:TIGR04523  364 ELEEKQNEIEKlKKENQSYKQEIKNLESQINDLESKIQ-----------NQEKLNQQKDEQIKKLQQEKELLEKEIERLK 432

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   707 SSNCKLMNTTEFQKEQIELLHKNIGTYKQQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQEN 786
Cdd:TIGR04523  433 ETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKV 512

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   787 RILRDTSSRL-----QIEKETYHREQQSQSLL--LNSLEFIKT--NLERSEMEGRQRLEQrLDDTVRELAAQRRHFQEEE 857
Cdd:TIGR04523  513 KDLTKKISSLkekieKLESEKKEKESKISDLEdeLNKDDFELKkeNLEKEIDEKNKEIEE-LKQTQKSLKKKQEEKQELI 591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   858 EKFRESINEFKRQAETAIKLKDE-EKQL--ADKWQAELTSVREELAEKVNKVNELSKKLQEVLTPTLNDNPITaaNKRAR 934
Cdd:TIGR04523  592 DQKEKEKKDLIKEIEEKEKKISSlEKELekAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEI--IKKIK 669

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442623382   935 EFELKLDQATVEIESLTKELAKTREHgeqfYKMSQSAESEIKRLHELHGELvakqEEEIKKLRSSEAELKTRISDLE 1011
Cdd:TIGR04523  670 ESKTKIDDIIELMKDWLKELSLHYKK----YITRMIRIKDLPKLEEKYKEI----EKELKKLDEFSKELENIIKNFN 738
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1109-1555 2.38e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.77  E-value: 2.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1109 RESLQAAYDELLRSNAEAQKLLDKEREESEKRVADLHALNSNLHDQIEALASKLAVLASQSQNPNSSLNEsamdgdqsln 1188
Cdd:COG4717    48 LERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREE---------- 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1189 asgLTAAEEGRNNEQLLKIIKFLRKEKDLFAAKLDILKAENARLISEHAIQQKKVDELNGYlnQERAKSQTDVVSANKHE 1268
Cdd:COG4717   118 ---LEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAEL--QEELEELLEQLSLATEE 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1269 EVLRKIETLNAITDSNRILREERNALTLRVAELTDRISSVEKELFPLQcSNKELTSKIEEINVENTSLRTEAIKWRQRAN 1348
Cdd:COG4717   193 ELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAA-LEERLKEARLLLLIAAALLALLGLGGSLLSL 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1349 A----------------LVEKSNRNPEEFKRLQAEREHLAKLLTAEKELNKKQSDELTVLKQRMNTEIPMLNKQMQILDE 1412
Cdd:COG4717   272 IltiagvlflvlgllalLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQE 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1413 ARKKQVDEFTNLKQNNTRQTQDIMeLKNRLLQKEEELLKANEELETKDKTIADKETKELQLRKLAKRYKDFyiglqsqgg 1492
Cdd:COG4717   352 LLREAEELEEELQLEELEQEIAAL-LAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEEL--------- 421

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442623382 1493 gtESAAELEKVRSELEEVNNQLRALKDEHEKITKECDEVK---KRTEPETDTSAIRQEYKAKLDKL 1555
Cdd:COG4717   422 --LEALDEEELEEELEELEEELEELEEELEELREELAELEaelEQLEEDGELAELLQELEELKAEL 485
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
265-901 2.40e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 49.68  E-value: 2.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  265 EEYVGKLKKELDAK-EKLFEIFKSTES-DHLIQR-----EELLQGISEIKRLLEEAEEQCAQLTEQMETMKqKHSAELDE 337
Cdd:PRK03918  164 YKNLGEVIKEIKRRiERLEKFIKRTENiEELIKEkekelEEVLREINEISSELPELREELEKLEKEVKELE-ELKEEIEE 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  338 QNKKIQAMEQELASANDLLKQARE---------SNLESAICQLAPSAAVASRLIRsdlsLTELYSMYAKSSEELEMRnce 408
Cdd:PRK03918  243 LEKELESLEGSKRKLEEKIRELEErieelkkeiEELEEKVKELKELKEKAEEYIK----LSEFYEEYLDELREIEKR--- 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  409 IEQLKLQLKSIIAEISEsapiLEKQNSDYQKMKETNSELLREHDELLQNklclERELERALSTLNHNQNENKKLKQTHTD 488
Cdd:PRK03918  316 LSRLEEEINGIEERIKE----LEEKEERLEELKKKLKELEKRLEELEER----HELYEEAKAKKEELERLKKRLTGLTPE 387

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  489 lsrQVCMLLDELNCIRAGVKHVRIQPTRQLPTSESLISDNLvtfSSIEELVDRNTYLLNMSRELTELLEASEKNQDKMLL 568
Cdd:PRK03918  388 ---KLEKELEELEKAKEEIEEEISKITARIGELKKEIKELK---KAIEELKKAKGKCPVCGRELTEEHRKELLEEYTAEL 461

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  569 EQSKNHIRKLDARFAELEDLLTQknntVTTLLSKCDRYKKLYFAAQKKlgqntvdlddSNLEPNDSALDTsEQPAANFEE 648
Cdd:PRK03918  462 KRIEKELKEIEEKERKLRKELRE----LEKVLKKESELIKLKELAEQL----------KELEEKLKKYNL-EELEKKAEE 526

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  649 SRKLEKRVRQLEQQ---LEGEVKKYASLKENYDYYTSEKRKndalAQEQFDSMRKEVRELTSSNCKLMNTT-----EFQK 720
Cdd:PRK03918  527 YEKLKEKLIKLKGEiksLKKELEKLEELKKKLAELEKKLDE----LEEELAELLKELEELGFESVEELEERlkelePFYN 602

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  721 EQIELlhknigtykqqvttleertKNYEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSSrlqieK 800
Cdd:PRK03918  603 EYLEL-------------------KDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYS-----E 658

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  801 ETYHREQQSQSLLLNSLEFIKTNLERSEmEGRQRLEQRLDDTVRELAAqRRHFQEEEEKFRESINEFKRQAETAIKLKDE 880
Cdd:PRK03918  659 EEYEELREEYLELSRELAGLRAELEELE-KRREEIKKTLEKLKEELEE-REKAKKELEKLEKALERVEELREKVKKYKAL 736

                         650       660
                  ....*....|....*....|..
gi 442623382  881 EKQLADKWQAELTS-VREELAE 901
Cdd:PRK03918  737 LKERALSKVGEIASeIFEELTE 758
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1278-1547 2.63e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 49.73  E-value: 2.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1278 NAITDSNRILREE-RNALTLRVAELTDRISSVEKELFPLQCSNKELTSKIEEINVENTSLRTEAIKWRQRANALVEKSNR 1356
Cdd:pfam15921  295 NSIQSQLEIIQEQaRNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGN 374

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1357 NPEEFKRLQAEREHLAKLLTAEKELNKKQSDE-----LTVLKQR-----MNTEIPMLNKQMQILDEARKKQVDEFTNLKQ 1426
Cdd:pfam15921  375 LDDQLQKLLADLHKREKELSLEKEQNKRLWDRdtgnsITIDHLRrelddRNMEVQRLEALLKAMKSECQGQMERQMAAIQ 454

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1427 NNTRQTQDIMELKNRLLQKEEELLKANEELETKDKTIADKEtkelqlrklaKRYKDFYIGLQSQGGGTESA-AELEKVRS 1505
Cdd:pfam15921  455 GKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSE----------RTVSDLTASLQEKERAIEATnAEITKLRS 524

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 442623382  1506 ELEEVNNQLRALKDEHE---KITKECDEVK-KRTEPETDTSAIRQE 1547
Cdd:pfam15921  525 RVDLKLQELQHLKNEGDhlrNVQTECEALKlQMAEKDKVIEILRQQ 570
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 127-442 2.63e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.55  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  127 IERQQAELER----------LKQDLHTYQQQLssaiaakceAIARVDEIQSKEVALELKENRMESERDMLHKEILLIsgd 196
Cdd:COG1196   198 LERQLEPLERqaekaeryreLKEELKELEAEL---------LLLKLRELEAELEELEAELEELEAELEELEAELAEL--- 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  197 lnksNAELQNIRREHTintmqlqsclkEKTESLKLMQEQYEQAVKTIGELTSKI----EMQNDTAFKQNQATEEYVGKLK 272
Cdd:COG1196   266 ----EAELEELRLELE-----------ELELELEEAQAEEYELLAELARLEQDIarleERRRELEERLEELEEELAELEE 330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  273 KELDAKEKLFEIfKSTESDHLIQREELLQGISEIKRLLEEAEEQCAQLTEQMETMKQKHSAELDEQNKKIQAMEQELASA 352
Cdd:COG1196   331 ELEELEEELEEL-EEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAE 409

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  353 NDLLkQARESNLESAICQLAPSAAVASRLIRSDLSLTELYSMYAKSSEELEMRNCEIEQLKLQLKSIIAEISESAPILEK 432
Cdd:COG1196   410 EALL-ERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAE 488

                         330
                  ....*....|
gi 442623382  433 QNSDYQKMKE 442
Cdd:COG1196   489 AAARLLLLLE 498
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
44-211 3.00e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.53  E-value: 3.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   44 RAAANRLAEAEQKKEELENKMEDY---------LVKFTSFELNVNELRTHLDQMSSERVNL---MDTIAKGEQTISQLRK 111
Cdd:COG4913   620 AELEEELAEAEERLEALEAELDALqerrealqrLAEYSWDEIDVASAEREIAELEAELERLdasSDDLAALEEQLEELEA 699

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  112 EKASVVEERDSMMKVIERQQAELERLKQDLHTYQQQLSSAIAAKCEA-IARVDEiqskEVALELKENRMESERDMLHKEI 190
Cdd:COG4913   700 ELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLElRALLEE----RFAAALGDAVERELRENLEERI 775

                         170       180
                  ....*....|....*....|.
gi 442623382  191 LLISGDLNKSNAELQNIRREH 211
Cdd:COG4913   776 DALRARLNRAEEELERAMRAF 796
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 102-504 4.72e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 48.81  E-value: 4.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   102 GEQTISQLRKEKASVVEERDSMMKVIERQQAELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQsKEVALELKENRMES 181
Cdd:TIGR00618  533 GEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQ-DLTEKLSEAEDMLA 611

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   182 ERDMLHKEILLISGDLNKSNAELQNIRREhtintMQLQSCLKEKTEsLKLMQEQYEQAVKTIGELTSKIEMQNDTAFKQN 261
Cdd:TIGR00618  612 CEQHALLRKLQPEQDLQDVRLHLQQCSQE-----LALKLTALHALQ-LTLTQERVREHALSIRVLPKELLASRQLALQKM 685

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   262 QATEEYVGKLKKELdakeklfeifkstesdhliqreellqgiseikrlleeaeEQCAQLTEQMETMKQKHSAELDEQNKK 341
Cdd:TIGR00618  686 QSEKEQLTYWKEML---------------------------------------AQCQTLLRELETHIEEYDREFNEIENA 726

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   342 IQAMEQELASANDLLKQARESNLESAICQLAPSAAVASRLIRSDLSLTELYSMYAKSSEELEMRNCEIEQLKLQLKSIIA 421
Cdd:TIGR00618  727 SSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEA 806

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   422 EISESAPilekqnsDYQKMKETNSELLREHDELLQNKLCLERELERALSTLNHNQNENKKLKQTHTDLSRQVCMLLDELN 501
Cdd:TIGR00618  807 EIGQEIP-------SDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLN 879


                   ...
gi 442623382   502 CIR 504
Cdd:TIGR00618  880 GIN 882
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 835-1180 6.00e-05

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 48.51  E-value: 6.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  835 LEQRLDDTVRELAAQRRHFQEEEEKFRE---SINEF-KRQAETAIKLKDEEKQLADKW-------QAELTSVREELAEKV 903
Cdd:PRK10929  107 LEQEILQVSSQLLEKSRQAQQEQDRAREisdSLSQLpQQQTEARRQLNEIERRLQTLGtpntplaQAQLTALQAESAALK 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  904 NKVNEL------SKKLQEVltptlndnpitaANKRAREFELKLDQATVEIESLTKELAKTREhgeqfykmsQSAESEIKR 977
Cdd:PRK10929  187 ALVDELelaqlsANNRQEL------------ARLRSELAKKRSQQLDAYLQALRNQLNSQRQ---------REAERALES 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  978 LhelhgELVAKQEEEIKKLRSSEAELKTRISDL---EAEAMLSNVTEQSKTVNQSGQLKSAQDDLKSLLEKLTEANCTIR 1054
Cdd:PRK10929  246 T-----ELLAEQSGDLPKSIVAQFKINRELSQAlnqQAQRMDLIASQQRQAASQTLQVRQALNTLREQSQWLGVSNALGE 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1055 TLRSENTSLVEslnaaevkyangMIQHSADIQELTRYKAEFFKANDELNQLKSGRESLQAAYDELlrsNAEAQKLLDKE- 1133
Cdd:PRK10929  321 ALRAQVARLPE------------MPKPQQLDTEMAQLRVQRLRYEDLLNKQPQLRQIRQADGQPL---TAEQNRILDAQl 385

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 442623382 1134 REESEKrvadLHALNSNLHDQIEALaSKLAVLASQSQNPNSSLNESA 1180
Cdd:PRK10929  386 RTQREL----LNSLLSGGDTLILEL-TKLKVANSQLEDALKEVNEAT 427
PHA03169 PHA03169
hypothetical protein; Provisional
 2111-2260 6.39e-05

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 48.04  E-value: 6.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2111 EQPARLESAEV--DGTAEVAGGAPHESAGPSDTGAAS-ASSPQKQSEAGESSGSDALKAADDGGDHADGTDNAREADEAF 2187
Cdd:PHA03169  103 PTPSPSGSAEElaSGLSPENTSGSSPESPASHSPPPSpPSHPGPHEPAPPESHNPSPNQQPSSFLQPSHEDSPEEPEPPT 182

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442623382 2188 AEETMATGQGEDSqPLGNDNPNVGTSQSEVSHNQANLGEGNPteDSEGADGVSSEGEkqAVGVEEEGREAEAT 2260
Cdd:PHA03169  183 SEPEPDSPGPPQS-ETPTSSPPPQSPPDEPGEPQSPTPQQAP--SPNTQQAVEHEDE--PTEPEREGPPFPGH 250
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 837-1013 7.48e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.46  E-value: 7.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  837 QRLDDTVRELAAQRRHFQEEEEKFRESINEFKRQAETA-IKLKDEEKQLADKwqaeltsvREELAEKVNKVNELSKKLQE 915
Cdd:COG1579    13 QELDSELDRLEHRLKELPAELAELEDELAALEARLEAAkTELEDLEKEIKRL--------ELEIEEVEARIKKYEEQLGN 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  916 VLTPtlndnpitaankraREFElkldQATVEIESLTKELAKTREHGEQFYKMSQSAESEIKRLHELHGELVAKQEEEIKK 995
Cdd:COG1579    85 VRNN--------------KEYE----ALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAE 146

                         170
                  ....*....|....*...
gi 442623382  996 LRSSEAELKTRISDLEAE 1013
Cdd:COG1579   147 LDEELAELEAELEELEAE 164
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
416-1028 8.23e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 48.11  E-value: 8.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  416 LKSIIAEISESAPILEKQNSDYQKMKETNSELLREHDELLQNKLCLERELERALSTLNHNQNENKKLKQTHTDLSRQVCM 495
Cdd:PRK02224  211 LESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEE 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  496 LLDELNCIRAGVKHVRIQPTRQLPTSESLISDNLVTFSSIEEL-VDRNTYLLNMSRELTELLEASEKNQDKmlleqsKNH 574
Cdd:PRK02224  291 LEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECrVAAQAHNEEAESLREDADDLEERAEEL------REE 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  575 IRKLDARFAELEDLLTQKNNTVTTLLSKCDrykklyfAAQKKLGQNTVDLDDsnlepndsALDTSEQPAANFEESRKLEK 654
Cdd:PRK02224  365 AAELESELEEAREAVEDRREEIEELEEEIE-------ELRERFGDAPVDLGN--------AEDFLEELREERDELREREA 429

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  655 RVRQLEQQLEGEVKKYASLKENYDYYTSEKRKNDALAQEQFDSMRKEVRELTSSNCKLMNTTEFQKEQIELLHKNIGTYK 734
Cdd:PRK02224  430 ELEATLRTARERVEEAEALLEAGKCPECGQPVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEAED 509

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  735 qQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQSLLL 814
Cdd:PRK02224  510 -RIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERI 588

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  815 NSLEFIKTNLERSEmegrqrleqRLDDTVRELAAQRRHFQEEEekfresinefkrqaetaiklkDEEkqladkwqaelts 894
Cdd:PRK02224  589 ESLERIRTLLAAIA---------DAEDEIERLREKREALAELN---------------------DER------------- 625

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  895 vREELAEKVNKVNELSKKLQEvltptlndnpitAANKRAREfelKLDQATVEIESLTKELAKTREHGEQFYKMSQSAESE 974
Cdd:PRK02224  626 -RERLAEKRERKRELEAEFDE------------ARIEEARE---DKERAEEYLEQVEEKLDELREERDDLQAEIGAVENE 689

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 442623382  975 IKRLHELHGELVAKQE--EEIKKLRSSEAELKTRISDLEAEAMLSNVTEQSKTVNQ 1028
Cdd:PRK02224  690 LEELEELRERREALENrvEALEALYDEAEELESMYGDLRAELRQRNVETLERMLNE 745
46 PHA02562
endonuclease subunit; Provisional
 1370-1620 8.40e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 47.70  E-value: 8.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1370 HLAKLLTAEKELNKKQSDELTVLKQRMNTEIPMLNKQMqilDEARKKQvdeftnlKQNNTRQTQDIMELKNRLLQKEEEL 1449
Cdd:PHA02562  167 EMDKLNKDKIRELNQQIQTLDMKIDHIQQQIKTYNKNI---EEQRKKN-------GENIARKQNKYDELVEEAKTIKAEI 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1450 LKANEELETKDKTIADKETkelQLRKLakryKDFYIGLQSQgggTESAAELEKVRSELEEVNNQLRALKDEHEKITKECD 1529
Cdd:PHA02562  237 EELTDELLNLVMDIEDPSA---ALNKL----NTAAAKIKSK---IEQFQKVIKMYEKGGVCPTCTQQISEGPDRITKIKD 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1530 EVKKRTEPETDTSAIRQEYKAKLDKLVvDLTVARTDLVNQETTFAGTKSSYDETIARLEKELQENIAANKDINQRLTREN 1609
Cdd:PHA02562  307 KLKELQHSLEKLDTAIDELEEIMDEFN-EQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQ 385

                         250
                  ....*....|.
gi 442623382 1610 ESLHMRINQLT 1620
Cdd:PHA02562  386 DELDKIVKTKS 396
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 568-1393 9.54e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 47.76  E-value: 9.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   568 LEQSKNHIRKLDARFAELEDLLTQKNNTVTTLlsKCDRYKKL-YFAAQKKLGQNTVDLDDSNLEPNDSALDTSEQpaanf 646
Cdd:TIGR02169  172 KEKALEELEEVEENIERLDLIIDEKRQQLERL--RREREKAErYQALLKEKREYEGYELLKEKEALERQKEAIER----- 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   647 eESRKLEKRVRQLEQQLEGEVKKYASLKENYDyytSEKRKNDALAQEQFDSMRKEVRELTSSNCKLMNTTEFQKEQIELL 726
Cdd:TIGR02169  245 -QLASLEEELEKLTEEISELEKRLEEIEQLLE---ELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDA 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   727 HKNIGTYKQQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSSRLQIEKETYHRE 806
Cdd:TIGR02169  321 EERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKRE 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   807 qqsqslllnsLEFIKTNLERSEMEGRQRLEQRLD--DTVRELAAQRRHFQEEEEKFRESINEFKRQAETAIK-LKDEEKQ 883
Cdd:TIGR02169  401 ----------INELKRELDRLQEELQRLSEELADlnAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAAdLSKYEQE 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   884 LA------DKWQAELTSVREELAEK--------------VNKVNELSKKLQEV-------------------------LT 918
Cdd:TIGR02169  471 LYdlkeeyDRVEKELSKLQRELAEAeaqaraseervrggRAVEEVLKASIQGVhgtvaqlgsvgeryataievaagnrLN 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   919 PTLNDNPITAanKRAREF--ELKLDQATV----EIESLTKELAKTREHGEQFYKMS----------------------QS 970
Cdd:TIGR02169  551 NVVVEDDAVA--KEAIELlkRRKAGRATFlplnKMRDERRDLSILSEDGVIGFAVDlvefdpkyepafkyvfgdtlvvED 628

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   971 AESE-----IKRLHELHGELVAK-------------QEEEIKKLRSSEAELKTRISDLEAEamLSNVTEQsktvnqsgqL 1032
Cdd:TIGR02169  629 IEAArrlmgKYRMVTLEGELFEKsgamtggsraprgGILFSRSEPAELQRLRERLEGLKRE--LSSLQSE---------L 697

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1033 KSAQDDLKSLLEKLTEANCTIRTLRSENTSLVESLNAAEVKYANGMIQHSADIQELTRYKAEFFKANDELNQLKSGRESL 1112
Cdd:TIGR02169  698 RRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKL 777

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1113 QAAYDELLRSNAEAQ-KLLDKEREESEKRVADLHALNSNLHDQIEALASKLAVLASQSQNPNSSLNEsamdgdqslnasg 1191
Cdd:TIGR02169  778 EEALNDLEARLSHSRiPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRID------------- 844

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1192 ltaAEEGRNNEQllKIIKFLRKEKDLFAAKLDILKAENARLISEHAIQQKKVDELNgylnqeraksqtdvvsaNKHEEVL 1271
Cdd:TIGR02169  845 ---LKEQIKSIE--KEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELE-----------------AQLRELE 902

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1272 RKIETLNAitdsnrilreERNALTLRVAELTDRISSVEKELFPLQCSNKELTSKIEEINVENTsLRTEAIKWRQRANALV 1351
Cdd:TIGR02169  903 RKIEELEA----------QIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLED-VQAELQRVEEEIRALE 971

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*
gi 442623382  1352 EKSNRNPEEFKRLQAEREHLAK---LLTAEKELNKKQSDELTVLK 1393
Cdd:TIGR02169  972 PVNMLAIQEYEEVLKRLDELKEkraKLEEERKAILERIEEYEKKK 1016
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
55-586 1.10e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 47.75  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   55 QKKEELENKMEDYLVKFTSFELNVNELRTHLDQMSSERVNLMDTIAKGEQT---ISQLRKEKASVveerdsmmkviERQQ 131
Cdd:PRK03918  186 KRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELkeeIEELEKELESL-----------EGSK 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  132 AELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALElkenRMESERDMLHKEILLISGDLNKSNAELQNIRREh 211
Cdd:PRK03918  255 RKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYI----KLSEFYEEYLDELREIEKRLSRLEEEINGIEER- 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  212 tintmqlQSCLKEKTESLKLMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQA-------TEEYVGKLKKELDAKEKlfei 284
Cdd:PRK03918  330 -------IKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELerlkkrlTGLTPEKLEKELEELEK---- 398

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  285 fkstesdhliQREELLQGISEIKRLLEEAEEQCAQLTEQMETMKQKHS------AELDEQNKK---------IQAMEQEL 349
Cdd:PRK03918  399 ----------AKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGkcpvcgRELTEEHRKelleeytaeLKRIEKEL 468

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  350 ASANDLLKQARES--NLESAIcqlapsaAVASRLIRSDLSLTELYSMYAKSS----EELEMRNCEIEQLKL-------QL 416
Cdd:PRK03918  469 KEIEEKERKLRKElrELEKVL-------KKESELIKLKELAEQLKELEEKLKkynlEELEKKAEEYEKLKEkliklkgEI 541

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  417 KSIIAEISESAPILEKQNSDYQKMKETNSELLREHDELLQNKLCLERELERALSTLNHNQNENKKLKQTHTDLSRQVCML 496
Cdd:PRK03918  542 KSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREEKEL 621

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  497 LDELNCIRAGVKHVRIQPTRqLPTSESLISDNLVTFSSIEELVDRNTYlLNMSRELTELLEASEKNQDkmLLEQSKNHIR 576
Cdd:PRK03918  622 KKLEEELDKAFEELAETEKR-LEELRKELEELEKKYSEEEYEELREEY-LELSRELAGLRAELEELEK--RREEIKKTLE 697

                         570
                  ....*....|
gi 442623382  577 KLDARFAELE 586
Cdd:PRK03918  698 KLKEELEERE 707
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
555-1057 1.12e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.45  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  555 LLEASEKNQDKMLLEQSKNHIRKLDaRFAELEDLLTQKnntvttllskcDRYKKLYFAAQKKLGQNTVDLDdsNLEPNDS 634
Cdd:COG4717    47 LLERLEKEADELFKPQGRKPELNLK-ELKELEEELKEA-----------EEKEEEYAELQEELEELEEELE--ELEAELE 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  635 ALDTSEQPAANFEESRKLEKRVRQLEQQLEGEVKKYASLKENYDYYTSekrkndalAQEQFDSMRKEVRELTSSNCKLMN 714
Cdd:COG4717   113 ELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRE--------LEEELEELEAELAELQEELEELLE 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  715 TTEFQKEQiellhkNIGTYKQQVTTLEERTKNYEKTIIKHEQTVHLLKDEmMAAHRKHAAADAEAQSLRQENRILRDTSS 794
Cdd:COG4717   185 QLSLATEE------ELQDLAEELEELQQRLAELEEELEEAQEELEELEEE-LEQLENELEAAALEERLKEARLLLLIAAA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  795 RLQIekETYHREQQSQSLLLNSLEFIKTNLERSEMEGRQRLEQRLDDTVRELAAQRRHFQEEEEKFRESINEFKRQAETA 874
Cdd:COG4717   258 LLAL--LGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLS 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  875 IKLKDEEKQLADKWQAELTSVREELAEKvnKVNELSKKLQEVLTPTLNDNpITAANKRAREFElKLDQATVEIESLTKEL 954
Cdd:COG4717   336 PEELLELLDRIEELQELLREAEELEEEL--QLEELEQEIAALLAEAGVED-EEELRAALEQAE-EYQELKEELEELEEQL 411

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  955 AKTREHGEQFYKMSQSAESEiKRLHELHGELvAKQEEEIKKLRSSEAELKTRISDLEAEAMLSnvteqsktvnqsgQLKS 1034
Cdd:COG4717   412 EELLGELEELLEALDEEELE-EELEELEEEL-EELEEELEELREELAELEAELEQLEEDGELA-------------ELLQ 476

                         490       500
                  ....*....|....*....|...
gi 442623382 1035 AQDDLKSLLEKLTEANCTIRTLR 1057
Cdd:COG4717   477 ELEELKAELRELAEEWAALKLAL 499
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
986-1522 1.44e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 47.34  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  986 VAKQEEEIKklrssEAELKTRISDLEAEamLSNVTEQSKTVN-QSGQLKSAQDDLKSLLEKLTEANCTIRTLRSENTSLV 1064
Cdd:PRK02224  192 LKAQIEEKE-----EKDLHERLNGLESE--LAELDEEIERYEeQREQARETRDEADEVLEEHEERREELETLEAEIEDLR 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1065 ESLNAAEVKYANgmiqHSADIQELTRYKAEFFKANDELnqlkSGRESLQAAYDELLrsnAEAQKLLDKEREESEKRVADL 1144
Cdd:PRK02224  265 ETIAETEREREE----LAEEVRDLRERLEELEEERDDL----LAEAGLDDADAEAV---EARREELEDRDEELRDRLEEC 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1145 HALNSNLHDQIEALASKLAVLASQSQNpnssLNESAMDGDQSLNASGLTAAEEGRNNEQLLKIIKFLRKEKDLFAAKLDI 1224
Cdd:PRK02224  334 RVAAQAHNEEAESLREDADDLEERAEE----LREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGN 409

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1225 LKAENARLISEHaiqqkkvDELNGYLNQERAKSQTDVVSANKHEEVLRK---------------IETLNAITDSNRILRE 1289
Cdd:PRK02224  410 AEDFLEELREER-------DELREREAELEATLRTARERVEEAEALLEAgkcpecgqpvegsphVETIEEDRERVEELEA 482

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1290 ERNALTLRVAELTDRI------SSVEKELFPLQCSNKELTS--------------KIEEINVENTSLRTEAIKWRQRANA 1349
Cdd:PRK02224  483 ELEDLEEEVEEVEERLeraedlVEAEDRIERLEERREDLEEliaerretieekreRAEELRERAAELEAEAEEKREAAAE 562

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1350 LVEKSNRNPEEFKRLQAEREHLAKLLTAEKELNKKQSdeltvlkqrmntEIPMLNKQMQILDEARKkqvdeftNLKQNNT 1429
Cdd:PRK02224  563 AEEEAEEAREEVAELNSKLAELKERIESLERIRTLLA------------AIADAEDEIERLREKRE-------ALAELND 623

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1430 RQTQDIMELKNRLLQKEEELLKANEELETKDKTIADK--ETKELQLRKLAKRYKDfyigLQSQGGGTESA-AELEKVRSE 1506
Cdd:PRK02224  624 ERRERLAEKRERKRELEAEFDEARIEEAREDKERAEEylEQVEEKLDELREERDD----LQAEIGAVENElEELEELRER 699

                         570
                  ....*....|....*.
gi 442623382 1507 LEEVNNQLRALKDEHE 1522
Cdd:PRK02224  700 REALENRVEALEALYD 715
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 45-273 1.48e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.68  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   45 AAANRLAEAEQKKEELENKMEdylvkftsfelnvnELRTHLDQMSSERVNLMDTIAKGEQTISQLRKEKASVVEERDSMM 124
Cdd:COG4942    17 AQADAAAEAEAELEQLQQEIA--------------ELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  125 KVIERQQAELERLKQDLHTYQQQLSSAIAA--KCEAIARVDEIQSKEVALELKENRMESERdmLHKEILLISGDLNKSNA 202
Cdd:COG4942    83 AELAELEKEIAELRAELEAQKEELAELLRAlyRLGRQPPLALLLSPEDFLDAVRRLQYLKY--LAPARREQAEELRADLA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442623382  203 ELQNIRREHTINTMQLQSCLKEKTESLKLMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQATEEYVGKLKK 273
Cdd:COG4942   161 ELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 309-904 1.50e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 47.24  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  309 LLEEAEEQCAQLTEQMETMK--QKHSAELDEqnkkiqaMEQELASANDLLKQARESNLESAIcqlapsAAVASRLIRSDL 386
Cdd:COG1196   194 ILGELERQLEPLERQAEKAEryRELKEELKE-------LEAELLLLKLRELEAELEELEAEL------EELEAELEELEA 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  387 SLTELYSMYAKSSEELEMRNCEIEQLKLQLKSIIAEISESAPILEKQNSDYQKMKETNSELLREHDELLQNKLCLERELE 466
Cdd:COG1196   261 ELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELE 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  467 RALSTLNHNQNENKKLKQTHTDLSRQVCMLLDELNCIRAGVKHVRIQPTRQLPTSESLISDNLVTFSSIEELVDRntyLL 546
Cdd:COG1196   341 ELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLER---LE 417

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  547 NMSRELTELLEASEKNQDKmlLEQSKNHIRKLDARFAELEDLLTQKNNTVTTLLSKCDRYKKLYFAAQKKLGQNTVDLD- 625
Cdd:COG1196   418 RLEEELEELEEALAELEEE--EEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLl 495

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  626 DSNLEPNDSALDTSEQPAANFEESRKLEKRVRQLEQQLEGEVKKYASLKENYDYYTSEKRKNDALAQEQFDSMRK----- 700
Cdd:COG1196   496 LLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKagrat 575

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  701 -------EVRELTSSNCKLMNTTEFQKEQIELLHKNIGTYKQQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAAHRKHA 773
Cdd:COG1196   576 flpldkiRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEG 655

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  774 AADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQSLLLNSLEfiktNLERSEMEGRQRLEQRLDDTVRELAAQRRHF 853
Cdd:COG1196   656 GSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALL----AEEEEERELAEAEEERLEEELEEEALEEQLE 731

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|...
gi 442623382  854 QEEEEKFRESINEFKRQAETAIKLKDEEKQLADkWQAELTSVREELAE--KVN 904
Cdd:COG1196   732 AEREELLEELLEEEELLEEEALEELPEPPDLEE-LERELERLEREIEAlgPVN 783
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 295-493 1.55e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.68  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  295 QREELLQGISEIKRLLEEAEEQCAQLTEQMETMKQKhsaeLDEQNKKIQAMEQELASANDLLKQAR------ESNLESAI 368
Cdd:COG4942    28 ELEQLQQEIAELEKELAALKKEEKALLKQLAALERR----IAALARRIRALEQELAALEAELAELEkeiaelRAELEAQK 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  369 CQLAPSAAVASRLIRSDlSLTELYSmyAKSSEELEMRNCEIEQLKLQLKSIIAEISESAPILEKQNSDYQKMKETNSELL 448
Cdd:COG4942   104 EELAELLRALYRLGRQP-PLALLLS--PEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALL 180

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 442623382  449 REHDELLQNKLCLERELERALSTLNHN----QNENKKLKQTHTDLSRQV 493
Cdd:COG4942   181 AELEEERAALEALKAERQKLLARLEKElaelAAELAELQQEAEELEALI 229
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
23-383 1.68e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.07  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   23 EDVQKKLSEYINNFSDeYCKNRAAANRLAEAEQKKEELENKMEDYlvkfTSFELNVNELRTHLDQMSSERVNLMDTI-AK 101
Cdd:COG4717   115 REELEKLEKLLQLLPL-YQELEALEAELAELPERLEELEERLEEL----RELEEELEELEAELAELQEELEELLEQLsLA 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  102 GEQTISQLRKEKASVVEERDSMMKVIERQQAELERLKQDLHTYQQQL-SSAIAAKCEAIARVDEIQSKEVALELKENRME 180
Cdd:COG4717   190 TEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELeAAALEERLKEARLLLLIAAALLALLGLGGSLL 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  181 SERDMLHKEILLISG--------------DLNKSNAELQNIRREHTINTMQLQSCLKEKTESLKLMQEQYEQAVKTIGEL 246
Cdd:COG4717   270 SLILTIAGVLFLVLGllallflllarekaSLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEEL 349

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  247 TSKIEmqndtafKQNQATEEYvgKLKKELDAKEKLFEIFKSTESDHLIQREELLQGISEIKRLLEEAEEQCAQLTEQMET 326
Cdd:COG4717   350 QELLR-------EAEELEEEL--QLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEE 420

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 442623382  327 MKQKHsaELDEQNKKIQAMEQELASANDLLKQARE--SNLESAICQLAPSAAVASRLIR 383
Cdd:COG4717   421 LLEAL--DEEELEEELEELEEELEELEEELEELREelAELEAELEQLEEDGELAELLQE 477
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
22-243 1.74e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.93  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   22 PEDVQKKLSEYINNFSDEYCKNRAAA---------NRLAEAEQKKEELENKMEDYLVK--FTSFELNVNELRTHLDQMSS 90
Cdd:COG3206   147 PELAAAVANALAEAYLEQNLELRREEarkalefleEQLPELRKELEEAEAALEEFRQKngLVDLSEEAKLLLQQLSELES 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   91 ERVNLMDTIAKGEQTISQLRKEKASVVEE-----RDSMMKVIERQQAELERLKQDL-------H----TYQQQLSSAIAA 154
Cdd:COG3206   227 QLAEARAELAEAEARLAALRAQLGSGPDAlpellQSPVIQQLRAQLAELEAELAELsarytpnHpdviALRAQIAALRAQ 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  155 KCEAIARV-DEIQSKEVALELKENRMESERDMLHKEILlisgDLNKSNAELQNIRREHTINTMQLQScLKEKTESLKLMQ 233
Cdd:COG3206   307 LQQEAQRIlASLEAELEALQAREASLQAQLAQLEARLA----ELPELEAELRRLEREVEVARELYES-LLQRLEEARLAE 381

                         250
                  ....*....|
gi 442623382  234 EQYEQAVKTI 243
Cdd:COG3206   382 ALTVGNVRVI 391
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1032-1625 1.82e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 47.14  E-value: 1.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1032 LKSAQDDLKSLLEKLTEANCTIRTLRSENTSLVESLNAAEVKYANGMIQHSADIQELTrykaeffkanDELNQ-LKSGRE 1110
Cdd:pfam12128  246 LQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKR----------DELNGeLSAADA 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1111 SLQAAYDELLRSNAEAQKLLDkerEESEKRVADLHALNSnLHDQIEALASKLAVLASQSQNPNSSLNESAMDGDQSLNAs 1190
Cdd:pfam12128  316 AVAKDRSELEALEDQHGAFLD---ADIETAAADQEQLPS-WQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQNNR- 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1191 gltaaEEGRNNEQLLKIikflRKEKDL-FAAKLDILKAENARLISEHAIQ-----------QKKVDELNGYLNQERAKSQ 1258
Cdd:pfam12128  391 -----DIAGIKDKLAKI----REARDRqLAVAEDDLQALESELREQLEAGklefneeeyrlKSRLGELKLRLNQATATPE 461

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1259 TDVVSANKHEEVLRKIETLNAITDSNRILREERNALTLRVAELTDRISSVEKELFPLQCSNKEL-TSKIEEINVENTSLR 1337
Cdd:pfam12128  462 LLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELeLQLFPQAGTLLHFLR 541

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1338 TEAIKWRQR-----ANALVEKSNRNPE-----------------EFKRLQA------EREHLAKLLTAEKELNKKQSdel 1389
Cdd:pfam12128  542 KEAPDWEQSigkviSPELLHRTDLDPEvwdgsvggelnlygvklDLKRIDVpewaasEEELRERLDKAEEALQSARE--- 618

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1390 tvLKQRMNTEIPMLNKQmqiLDEARKKQVDEFTNLKQNNTRQTQDIMELKNRLLQKEEELLKANEELETKDKTIadketk 1469
Cdd:pfam12128  619 --KQAAAEEQLVQANGE---LEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSANERLNSL------ 687

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1470 ELQLRKLAKRYKDFYIGLQSQgGGTESAAELEKVRSELEEVNNQLRALKDE-------HEKITKECDEVKKRT------E 1536
Cdd:pfam12128  688 EAQLKQLDKKHQAWLEEQKEQ-KREARTEKQAYWQVVEGALDAQLALLKAAiaarrsgAKAELKALETWYKRDlaslgvD 766

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1537 PETDT--SAIRQEYKAKLDKLVVDLTVARTDLVNQETTFAGTKSSYDETIARLEKELQEniaankdINQRLTRENESLHM 1614
Cdd:pfam12128  767 PDVIAklKREIRTLERKIERIAVRRQEVLRYFDWYQETWLQRRPRLATQLSNIERAISE-------LQQQLARLIADTKL 839

                          650
                   ....*....|.
gi 442623382  1615 RINQLTRQLGS 1625
Cdd:pfam12128  840 RRAKLEMERKA 850
PRK01156 PRK01156
chromosome segregation protein; Provisional
 666-1163 2.01e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.82  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  666 EVKKYASLKENYDyytsekrkndaLAQEQFDSMRKEVRELTSSNCKL---MNTTEFQKEQIELLHKNIGTYKQQVTTLEE 742
Cdd:PRK01156  157 EILEINSLERNYD-----------KLKDVIDMLRAEISNIDYLEEKLkssNLELENIKKQIADDEKSHSITLKEIERLSI 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  743 RTKNYEKTIIKHEQTVHLLKDEMMAAHRKH---AAADAEAQSLRQENRILRDTSSRlqieketyHREQQSQSLLLNSLEF 819
Cdd:PRK01156  226 EYNNAMDDYNNLKSALNELSSLEDMKNRYEseiKTAESDLSMELEKNNYYKELEER--------HMKIINDPVYKNRNYI 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  820 IKTNLERSEMEGRQRLEQRLDDTVRELAAQRRHFqEEEEKFRESINEFKRQAETAIKLKDEEKQLADKWQAELTSVrEEL 899
Cdd:PRK01156  298 NDYFKYKNDIENKKQILSNIDAEINKYHAIIKKL-SVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSYLKSI-ESL 375

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  900 AEKVNKVNELSKKLQEVLTPTLNDNPITAA--NKRAREFELKLDQATVEIESLTKELAKTREHGEQFYKM---------- 967
Cdd:PRK01156  376 KKKIEEYSKNIERMSAFISEILKIQEIDPDaiKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNmemlngqsvc 455

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  968 ----SQSAESEIKRLHELHGELVAKQEE-------EIKKLRSSEAELKTRISDLEAEAMLSNVTEQSKTVNQSGQLKSAQ 1036
Cdd:PRK01156  456 pvcgTTLGEEKSNHIINHYNEKKSRLEEkireieiEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIK 535

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1037 DDLKSLLEKLTEANCTIRTLRSENtslVESLNAAEVKYANGMIQHSA-DIQELTRYKAEFFK----ANDELNQLKSGRES 1111
Cdd:PRK01156  536 IKINELKDKHDKYEEIKNRYKSLK---LEDLDSKRTSWLNALAVISLiDIETNRSRSNEIKKqlndLESRLQEIEIGFPD 612

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 442623382 1112 LQAAYDELLRSNAEAQKLLDKEREESEkrvaDLHALNSNLHDQIEALASKLA 1163
Cdd:PRK01156  613 DKSYIDKSIREIENEANNLNNKYNEIQ----ENKILIEKLRGKIDNYKKQIA 660
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 745-917 2.27e-04

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 44.51  E-value: 2.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   745 KNYEKTII-KHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQSLLLNSLEFIKTN 823
Cdd:pfam13851   14 KNYYNDITrNNLELIKSLKEEIAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLENYEKDKQSLKNLKAR 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   824 LERSEMEGR------QRLEQRLDDTVRElaaqrrhFQEEEEKFRESINE------FKRQA-ETAIKLKDEEkqlADKWQA 890
Cdd:pfam13851   94 LKVLEKELKdlkwehEVLEQRFEKVERE-------RDELYDKFEAAIQDvqqktgLKNLLlEKKLQALGET---LEKKEA 163

                          170       180
                   ....*....|....*....|....*..
gi 442623382   891 ELTSVREELAEKVNKVNELSKKLQEVL 917
Cdd:pfam13851  164 QLNEVLAAANLDPDALQAVTEKLEDVL 190
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 61-751 3.16e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 46.17  E-value: 3.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    61 ENKMEDYLVKFTSFELNVNELRTHLDQMSSERVNLMDTIAKGEQTISQLRKEKASVVEERDSMMKVIERQQAELERLKQD 140
Cdd:TIGR04523   53 EKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQ 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   141 LHTYQQQLSSAIaakceaiarvDEIQSKEVALEL---KENRMESERDMLHKEILLISGDLNKSNAELQNIRREHTINTMQ 217
Cdd:TIGR04523  133 KKENKKNIDKFL----------TEIKKKEKELEKlnnKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELL 202

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   218 LqSCLKEKTESLKLMQEQYEQAVKTIGELTSKIEMQNDtafKQNQATEEYVGKLKKELDAKEKLFEIFKstesdhliQRE 297
Cdd:TIGR04523  203 L-SNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQ---EINEKTTEISNTQTQLNQLKDEQNKIKK--------QLS 270

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   298 ELLQGISEIKRLLEEAEEQCAQLTEQMETMKQKHSA--------ELDEQNKKIQAMEQELASANDLLkqareSNLESAIC 369
Cdd:TIGR04523  271 EKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQdwnkelksELKNQEKKLEEIQNQISQNNKII-----SQLNEQIS 345

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   370 QLAPSaavasrlirsdlsLTELYSMYAKSSEELEMRNCEIEQLKLQLKSIIAEISESAPILEKQNSDYQKMKETNSELLR 449
Cdd:TIGR04523  346 QLKKE-------------LTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDE 412

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   450 EHDELLQNKLCLERELERALSTLNHNQNENKKLKQTHTDLSRQVcmllDELNCIRAGVKhvriqptRQLPTSESLISDNL 529
Cdd:TIGR04523  413 QIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELII----KNLDNTRESLE-------TQLKVLSRSINKIK 481

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   530 VTFSSIE-ELVDRNTYLLNMSRELTELleaSEKNQD-KMLLEQSKNHIRKLDARFAELEDLLTQKNntvttllskcDRYK 607
Cdd:TIGR04523  482 QNLEQKQkELKSKEKELKKLNEEKKEL---EEKVKDlTKKISSLKEKIEKLESEKKEKESKISDLE----------DELN 548

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   608 KLYFAAQKKLGQNTVDLDDSNLEpndsaldtseQPAANFEESRKLEKRVRQLEQQLEGEVKKYASLKENYDYYTSEKRKn 687
Cdd:TIGR04523  549 KDDFELKKENLEKEIDEKNKEIE----------ELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEK- 617

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442623382   688 dalaqeQFDSMRKEVRELTSSNCKLMNTTEFQKEQIELLHKNIGTYKQQVTTLEERTKNYEKTI 751
Cdd:TIGR04523  618 ------ELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKI 675
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 16-343 4.99e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.43  E-value: 4.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    16 DELKLVPEDVQKKLSEYINNFSDEYCKNRAAANRLAEAEQKKEELENKMEDYLVKFTSFELNVNELRTHLDQMSSERVNL 95
Cdd:TIGR02168  715 EQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQL 794

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    96 MDTIAKGEQTISQLRKEKASVVEERDSMMKVIERQQAELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELK 175
Cdd:TIGR02168  795 KEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE 874

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   176 ENRMESERDMLHKEILLISGDLNKSNAELQNIRREhtintmqlqscLKEKTESLKLMQEQYEQAVKTIGELTSKIEMQND 255
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELESK-----------RSELRRELEELREKLAQLELRLEGLEVRIDNLQE 943

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   256 TAFKQNQATEEYVGKLKKELDAKEKLFEifkstesDHLIQREELLQGISEIKrllEEAEEQCAQLTEQMETMKqKHSAEL 335
Cdd:TIGR02168  944 RLSEEYSLTLEEAEALENKIEDDEEEAR-------RRLKRLENKIKELGPVN---LAAIEEYEELKERYDFLT-AQKEDL 1012


                   ....*...
gi 442623382   336 DEQNKKIQ 343
Cdd:TIGR02168 1013 TEAKETLE 1020
PTZ00121 PTZ00121
MAEBL; Provisional
 647-1469 4.99e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.52  E-value: 4.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  647 EESRKLEKRVRQLEQQLEGEVKKYASLKENYDYYTSEKRKNDALAQEQFDSMRKEvRELTSSNCKLMNTTEFQKEQIELL 726
Cdd:PTZ00121 1197 EDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNN-EEIRKFEEARMAHFARRQAAIKAE 1275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  727 HKNIGtykQQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAAhRKHAAADAEAQSLRQENRILRDTSSRLQIEKETYHRE 806
Cdd:PTZ00121 1276 EARKA---DELKKAEEKKKADEAKKAEEKKKADEAKKKAEEA-KKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAE 1351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  807 QQSQSLLLNSLEFIKTNLERSEMEGRQRLEQrlddtVRELAAQRRHFQEEEEKFRESinefKRQAEtAIKLKDEEKQLAD 886
Cdd:PTZ00121 1352 AEAAADEAEAAEEKAEAAEKKKEEAKKKADA-----AKKKAEEKKKADEAKKKAEED----KKKAD-ELKKAAAAKKKAD 1421

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  887 KWQAELTSVREelAEKVNKVNELSKKLQEVLTPTLNDNPITAANKRAREfELKLDQATVEIESLTK--ELAKTREHGEQF 964
Cdd:PTZ00121 1422 EAKKKAEEKKK--ADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEE-AKKADEAKKKAEEAKKadEAKKKAEEAKKK 1498

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  965 YKMSQSAESEIKRLHELHGELVAKQEEEIKKlrsseAELKTRISdleaEAMLSNVTEQSKTVNQSGQLKSAQDDLKSLLE 1044
Cdd:PTZ00121 1499 ADEAKKAAEAKKKADEAKKAEEAKKADEAKK-----AEEAKKAD----EAKKAEEKKKADELKKAEELKKAEEKKKAEEA 1569

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1045 KLTEANCTIRTLRSENTSLVESLNAAEVKYAngmiqhsadIQELTRYKAEffkandelnQLKSGRESLQAAydELLRSNA 1124
Cdd:PTZ00121 1570 KKAEEDKNMALRKAEEAKKAEEARIEEVMKL---------YEEEKKMKAE---------EAKKAEEAKIKA--EELKKAE 1629

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1125 EAQKLLD--KEREESEKRVADlhalnsNLHDQIEALASKLAVLASQSQNPNSSLNES--AMDGDQSLNASGLTAAEEGRN 1200
Cdd:PTZ00121 1630 EEKKKVEqlKKKEAEEKKKAE------ELKKAEEENKIKAAEEAKKAEEDKKKAEEAkkAEEDEKKAAEALKKEAEEAKK 1703

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1201 NEQLLKIIKFLRKEKDLFAAKLDILKAENARLISEHAIQQKKVDELNGYLNQERAKSQTDVVSANKHEEVLRKIETL--N 1278
Cdd:PTZ00121 1704 AEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVieE 1783

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1279 AITDSNRILREERNALTLRVAELTDRISSVEKELFPLQCSNKEL-TSKIEEINVENTSLRTEAIKWRQranalvEKSNRN 1357
Cdd:PTZ00121 1784 ELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMeDSAIKEVADSKNMQLEEADAFEK------HKFNKN 1857

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1358 PEEFKRLQAEREhlaklltAEKELNKKQSDELTVLKQRMNTEIPMLNKQMQILDearkkqvdefTNLKQNNTRQTQDIME 1437
Cdd:PTZ00121 1858 NENGEDGNKEAD-------FNKEKDLKEDDEEEIEEADEIEKIDKDDIEREIPN----------NNMAGKNNDIIDDKLD 1920

                         810       820       830
                  ....*....|....*....|....*....|..
gi 442623382 1438 LKNRLLQKEEELLKANEELETKDKTIADKETK 1469
Cdd:PTZ00121 1921 KDEYIKRDAEETREEIIKISKKDMCINDFSSK 1952
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1359-1630 5.36e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.31  E-value: 5.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1359 EEFKRLQAEREHL-AKLLTAEKELNKKQSDELTVLKQRMNTEIPMLNKQMQILDEARKKQVDEFTNLKQNNTRQTQDIME 1437
Cdd:COG1196   213 ERYRELKEELKELeAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1438 LKNRLLQKEEELLKANEELETKDKTIADKETKELQLRKLAKrykdfyiglqsqgggtESAAELEKVRSELEEVNNQLRAL 1517
Cdd:COG1196   293 LLAELARLEQDIARLEERRRELEERLEELEEELAELEEELE----------------ELEEELEELEEELEEAEEELEEA 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1518 KDEHEKITKECDEVKKRTEP-ETDTSAIRQEYKAKLDKLVVDLTvARTDLVNQETTFAGTKSSYDETIARLEKELQENIA 1596
Cdd:COG1196   357 EAELAEAEEALLEAEAELAEaEEELEELAEELLEALRAAAELAA-QLEELEEAEEALLERLERLEEELEELEEALAELEE 435

                         250       260       270
                  ....*....|....*....|....*....|....
gi 442623382 1597 ANKDINQRLTRENESLHMRINQLTRQLGSQQSTK 1630
Cdd:COG1196   436 EEEEEEEALEEAAEEEAELEEEEEALLELLAELL 469
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 764-917 6.35e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 45.33  E-value: 6.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  764 EMMAAHRKHAAADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQSLLLNSLEfiktNLERSEMEGRQRLEqRLDDTV 843
Cdd:COG3096   499 ELLRRYRSQQALAQRLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDAAE----ELEELLAELEAQLE-ELEEQA 573

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442623382  844 RELAAQRRHFQEEEEKFRESINEFKRQAETAIKLkdeekqladkwQAELTSVREELAEKVNKVNELSKKLQEVL 917
Cdd:COG3096   574 AEAVEQRSELRQQLEQLRARIKELAARAPAWLAA-----------QDALERLREQSGEALADSQEVTAAMQQLL 636
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
630-1058 6.43e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 45.03  E-value: 6.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  630 EPNDSALDTSEQPAANFE--ESRK--LEKRVRQLEQQLEGEVKKYASLKENYDYYtsekRKNDALAQEQFDSMRKEVREL 705
Cdd:PRK02224  293 EERDDLLAEAGLDDADAEavEARReeLEDRDEELRDRLEECRVAAQAHNEEAESL----REDADDLEERAEELREEAAEL 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  706 TSSNCKLMNTTEFQKEQIELLHKnigtykqQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLR-- 783
Cdd:PRK02224  369 ESELEEAREAVEDRREEIEELEE-------EIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARer 441

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  784 -QENRILRDTSSRL---QIEKETYH------REQQSQSLllnSLEFIKTNLERSEMEGR-QRLEQ--RLDDTVRELAAQR 850
Cdd:PRK02224  442 vEEAEALLEAGKCPecgQPVEGSPHvetieeDRERVEEL---EAELEDLEEEVEEVEERlERAEDlvEAEDRIERLEERR 518

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  851 RHFQEEEEKFRESINEFKRQAETAIKLKDEEKQLADKWQAELTSVREELAEKVNKVNELSKKLQEvltptlndnpitaaN 930
Cdd:PRK02224  519 EDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAE--------------L 584

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  931 KRAREFELKLDQATVEIESLTKELAKTREHGEQFYKMSQSAESEIKRLHELHGELVAK-QEEEIKKLRSSEAELKTRISD 1009
Cdd:PRK02224  585 KERIESLERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEfDEARIEEAREDKERAEEYLEQ 664

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 442623382 1010 LEAEamLSNVTEQSKTV-NQSGQLKSAQDDLKSLLEKLTEANCTIRTLRS 1058
Cdd:PRK02224  665 VEEK--LDELREERDDLqAEIGAVENELEELEELRERREALENRVEALEA 712
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 647-1173 6.99e-04

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 45.11  E-value: 6.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   647 EESRKLEKRVRQLEQQLEGEVKKYASLKENYDYYTSEKRKNDALAQEQFDSMRKEVRELTSSNCKLMNTTEfqkeqiell 726
Cdd:pfam15921  253 ESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLE--------- 323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   727 hkniGTYKQQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLR-QENRILRDTSSRlqiEKE-TYH 804
Cdd:pfam15921  324 ----STVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDdQLQKLLADLHKR---EKElSLE 396

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   805 REQQSQSLLLNSLEFIKTNLERSEMEGRQRLEQRLDDTVRELAAQRRHFQEEEEKFRESINEFKRQAETAIKLKDEEKQL 884
Cdd:pfam15921  397 KEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEM 476

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   885 ADKWQAELTSVREELAEKVNKVNELSKKLQEvltptlNDNPITAANKRAREFELKLDQATVEIESLTKE---LAKTREHG 961
Cdd:pfam15921  477 LRKVVEELTAKKMTLESSERTVSDLTASLQE------KERAIEATNAEITKLRSRVDLKLQELQHLKNEgdhLRNVQTEC 550

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   962 EQFY-------KMSQSAESEIKRLHEL---HGELV-------AKQEEEIKKLRSSEAELK-------TRISDLEAEamLS 1017
Cdd:pfam15921  551 EALKlqmaekdKVIEILRQQIENMTQLvgqHGRTAgamqvekAQLEKEINDRRLELQEFKilkdkkdAKIRELEAR--VS 628

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1018 NVT-EQSKTVNQSGQLKSAQDDLKSLLEKLTEancTIRTLRSENTSLVESLNAAEVKYANgmiqHSADIQELT-RYKAEF 1095
Cdd:pfam15921  629 DLElEKVKLVNAGSERLRAVKDIKQERDQLLN---EVKTSRNELNSLSEDYEVLKRNFRN----KSEEMETTTnKLKMQL 701

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442623382  1096 FKANDELNQLKSGRESLQAAYDELLRSNAEAQKLLDKEReesekrvadlhalnsnlhDQIEALASKLAVLASQSQNPN 1173
Cdd:pfam15921  702 KSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKR------------------GQIDALQSKIQFLEEAMTNAN 761
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
898-1127 8.79e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.62  E-value: 8.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  898 ELAEKVnkVNELSKKLQEvltptLNDNPITAANKRAREF-ELKLDQATVEIESLTKELAKTREHgEQFYKMSQSAESEIK 976
Cdd:COG3206   148 ELAAAV--ANALAEAYLE-----QNLELRREEARKALEFlEEQLPELRKELEEAEAALEEFRQK-NGLVDLSEEAKLLLQ 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  977 RLHELHGELVAKQEEeIKKLRSSEAELKTRISDLEAEamLSNVTEQSKTVNQSGQLKSAQDDLKSLLEKLTEANCTIRTL 1056
Cdd:COG3206   220 QLSELESQLAEARAE-LAEAEARLAALRAQLGSGPDA--LPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIAL 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1057 RSE--------NTSLVESLNAAEVKYANGMIQHSADIQELTRYKAEFFKAND---ELNQLKSGRESLQAAYDELLRSNAE 1125
Cdd:COG3206   297 RAQiaalraqlQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPEleaELRRLEREVEVARELYESLLQRLEE 376


                  ..
gi 442623382 1126 AQ 1127
Cdd:COG3206   377 AR 378
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 23-358 9.34e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 44.63  E-value: 9.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    23 EDVQKKLSEYINNFSDEYCKNRAAANRLAEAEQKKEELENKMEDYLVKFTSFELNVNElrTHLDQMSSERVNLMDTIAKG 102
Cdd:TIGR04523  263 NKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELKSELKNQE--KKLEEIQNQISQNNKIISQL 340

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   103 EQTISQLRKEKASVVEERDSMMKVIERQQAELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELKENRMESE 182
Cdd:TIGR04523  341 NEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQE 420

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   183 RDMLHKEILLISG----------DLNKSNAELQNIRREHTINTMQLQSCLKEKTESLKLMQEQYEQAVKTIGELTSKIEM 252
Cdd:TIGR04523  421 KELLEKEIERLKEtiiknnseikDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKK 500

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   253 QNdtafKQNQATEEYVGKLKK---ELDAKEKLFEIFKSTESDHLIQRE-ELLQGISEIKRllEEAEEQCAQLTEQMETMK 328
Cdd:TIGR04523  501 LN----EEKKELEEKVKDLTKkisSLKEKIEKLESEKKEKESKISDLEdELNKDDFELKK--ENLEKEIDEKNKEIEELK 574

                          330       340       350
                   ....*....|....*....|....*....|
gi 442623382   329 QKHSAELDEQNKKIQAMEQELASANDLLKQ 358
Cdd:TIGR04523  575 QTQKSLKKKQEEKQELIDQKEKEKKDLIKE 604
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
278-750 1.21e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.99  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  278 KEKLFEIFKSTESDHLIQREELLQGISEIKRLlEEAEEQCAQLTEqmetmkqkhsaELDEQNKKIQAMEQELASANDLLK 357
Cdd:COG4717    52 EKEADELFKPQGRKPELNLKELKELEEELKEA-EEKEEEYAELQE-----------ELEELEEELEELEAELEELREELE 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  358 QAResnlesAICQLAPSAAVASRLIRSDLSLTELYsmyakssEELEMRNCEIEQLKLQLKSIIAEISE-SAPILEKQNSD 436
Cdd:COG4717   120 KLE------KLLQLLPLYQELEALEAELAELPERL-------EELEERLEELRELEEELEELEAELAElQEELEELLEQL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  437 YQKMKETNSELLREHDELLQNKLCLERELERALSTLNHNQNENKKLKQTHTDLSRQVCMLLDELNCIRAGVKHVRIQPTR 516
Cdd:COG4717   187 SLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGG 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  517 QLPTSESLISDNLVTFSSI----EELVDRNTYLLNMSRELTELLEASEKNQDKMLLEQSKNHIRKLDARFAELEDLLTQK 592
Cdd:COG4717   267 SLLSLILTIAGVLFLVLGLlallFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRI 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  593 NNTVTTLLSKCDRYKKLYFAAQKKlgQNTVDLDDSNLEPndsaLDTSEQPAANFEESRKLEKRVRQLEQQLEGEVKKYAS 672
Cdd:COG4717   347 EELQELLREAEELEEELQLEELEQ--EIAALLAEAGVED----EEELRAALEQAEEYQELKEELEELEEQLEELLGELEE 420

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  673 LKENYDYYTSEKRKND-----ALAQEQFDSMRKEVRELTSSNCKLMNTTEFQ---------KEQIELLHKNIGTYKQQVT 738
Cdd:COG4717   421 LLEALDEEELEEELEEleeelEELEEELEELREELAELEAELEQLEEDGELAellqeleelKAELRELAEEWAALKLALE 500

                         490
                  ....*....|..
gi 442623382  739 TLEERTKNYEKT 750
Cdd:COG4717   501 LLEEAREEYREE 512
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 853-1482 1.39e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.86  E-value: 1.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   853 FQEEEEKFRESINEFKrqaetaiKLKDEEKQLADKWQAELTSVREELAEKVNKVNELSKKLQEVLTptlNDNPITAANKR 932
Cdd:TIGR04523   63 LNKDEEKINNSNNKIK-------ILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNK---LEVELNKLEKQ 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   933 AREFELKLDQATVEIESLTKELAKTREHGEQFYKMSQSAESEikrLHELHGELvAKQEEEIKKLRSSEAELKTRISDLEA 1012
Cdd:TIGR04523  133 KKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENE---LNLLEKEK-LNIQKNIDKIKNKLLKLELLLSNLKK 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1013 --------EAMLSNVTEQSKTVNQSGQLKsaQDDLKSLLEKLTEANCTIRTLRSENTSLVESLnaaevkyangmiqhSAD 1084
Cdd:TIGR04523  209 kiqknkslESQISELKKQNNQLKDNIEKK--QQEINEKTTEISNTQTQLNQLKDEQNKIKKQL--------------SEK 272

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1085 IQELTRYKAEFFKANDELNQLKSgreslqaaydELLRSNAEAQKLLDKEreesekrvadLHALNSNLHDQIEALASKLav 1164
Cdd:TIGR04523  273 QKELEQNNKKIKELEKQLNQLKS----------EISDLNNQKEQDWNKE----------LKSELKNQEKKLEEIQNQI-- 330

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1165 laSQSQNPNSSLNESAMDGDQSLNASGLTAAEEGRNNEQLLKIIKFLRKEKDLFAAKLDILKAEnarlISEHAIQQKKVD 1244
Cdd:TIGR04523  331 --SQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQ----INDLESKIQNQE 404

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1245 ELNGYLNQERAKSQTDVVSANKHEEVLRKIETLNAITDSNriLREERNALTLRVAELTDRISSVEKELFPLQCSNKELTS 1324
Cdd:TIGR04523  405 KLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKD--LTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQ 482

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1325 KIEEINVENTS-------LRTEAIKWRQRANALVEKSNRNPEEFKRLQAER-EHLAKLLTAEKELNKKQSD----ELTVL 1392
Cdd:TIGR04523  483 NLEQKQKELKSkekelkkLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKkEKESKISDLEDELNKDDFElkkeNLEKE 562

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1393 KQRMNTEIPMLNKQMQILDEARKKQVDEFTNLKQNNTRQTQDIMELKNRLLQKEEELLKANEELETKDKTIADKETKELQ 1472
Cdd:TIGR04523  563 IDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNK 642

                          650
                   ....*....|
gi 442623382  1473 LRKLAKRYKD 1482
Cdd:TIGR04523  643 LKQEVKQIKE 652
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 1937-2240 1.54e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 43.74  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1937 DSGMDVDQMPTSSQRDQEDDIQVVDSDDEEDVLADADDGPIDGGEAEQEGYEDS-YEQDNEMDDNEGGDDDNDIAVDAQD 2015
Cdd:NF033609  605 DSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDS 684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2016 NNEVDIEVPEQHMQAQEESQSLDNQAIATASASTQENNQSQAITSGSGESSNPVTLPQAEASNWKQAAASTSTAAARRNE 2095
Cdd:NF033609  685 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 764

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2096 SSVEIVSSPQVSNFCEQPARLESAEVDGTAEVAGGAPHESAGPSDTGAASASSPQKQSEAGESSGSDALKAADDGGDHAD 2175
Cdd:NF033609  765 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 844

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442623382 2176 GTDNAREAD-EAFAEETMATGQGEDSQPLGNDNPNVGTSQSevSHNQA-NLGEGNPTEDSEGADGVS 2240
Cdd:NF033609  845 DSDSDSDSDsDSESDSNSDSESGSNNNVVPPNSPKNGTNAS--NKNEAkDSKEPLPDTGSEDEANTS 909
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
637-1118 1.55e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 43.88  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  637 DTSEQPAANFEESRKLEKRVRQLEQQLEgevkkyaslkenydyyTSEKRKNDALAQEQFDSMRKE-----VRELTSSNCK 711
Cdd:PRK02224  262 DLRETIAETEREREELAEEVRDLRERLE----------------ELEEERDDLLAEAGLDDADAEavearREELEDRDEE 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  712 LMNTTEFQKEQIELLHKNIGTYKQQVTTLEERTK--------------NYEKTIIKHEQTVHLLKDEMMAAHRKHAAADA 777
Cdd:PRK02224  326 LRDRLEECRVAAQAHNEEAESLREDADDLEERAEelreeaaeleseleEAREAVEDRREEIEELEEEIEELRERFGDAPV 405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  778 EAQSLRQENRILRDTSSRLqieketyhREQqsqsllLNSLEFIKTNLERSEMEGRQRLE--------QRLDD-----TVR 844
Cdd:PRK02224  406 DLGNAEDFLEELREERDEL--------RER------EAELEATLRTARERVEEAEALLEagkcpecgQPVEGsphveTIE 471

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  845 ELAAQRRHFQEEEEKFRESINEFKRQAETAIKLKDEEKQL------ADKWQAELTSVREELAEKVNKVNELSKKLQEVlt 918
Cdd:PRK02224  472 EDRERVEELEAELEDLEEEVEEVEERLERAEDLVEAEDRIerleerREDLEELIAERRETIEEKRERAEELRERAAEL-- 549

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  919 ptlnDNPITAANKRAREFELKLDQATVEIESLTKELAKTREHGEQFYKMSQS------AESEIKRLHELHGELVAKQEEE 992
Cdd:PRK02224  550 ----EAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLlaaiadAEDEIERLREKREALAELNDER 625

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  993 IKKLrsseAELKTRISDLEAEAMLSNVTEqsktvnqsgqLKSAQDDLKSLLEKLTEAnctIRTLRSENTSLVESLNAAEv 1072
Cdd:PRK02224  626 RERL----AEKRERKRELEAEFDEARIEE----------AREDKERAEEYLEQVEEK---LDELREERDDLQAEIGAVE- 687

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 442623382 1073 kyangmiqhsADIQELTRYKaeffkanDELNQLKSGRESLQAAYDE 1118
Cdd:PRK02224  688 ----------NELEELEELR-------ERREALENRVEALEALYDE 716
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
763-1166 1.56e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.60  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  763 DEMMAAHRKHAAADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQSL------LLNSLEFIKTNLE--RSEMEGRQR 834
Cdd:COG4717    81 KEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLyqeleaLEAELAELPERLEelEERLEELRE 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  835 LEQRLDDTVRELAAQRRHFQEEEEKF----RESINEFKRQAETAIKLKDEEKQLADKWQAELTSVREELAEKVNKVneLS 910
Cdd:COG4717   161 LEEELEELEAELAELQEELEELLEQLslatEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENEL--EA 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  911 KKLQEVLtptlndnpitaankRAREFELKLDQATVEIESLTKELAKTREHGEQFYKMSQSAESEIKRLHELHGELVAKQE 990
Cdd:COG4717   239 AALEERL--------------KEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEA 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  991 EEIKKLRSSEAELKTRISDLEAEAMLSNVTEQSKTVNQSGQLKSAQDDLKSLLEKLTEAncTIRTLRSENTSLvesLNAA 1070
Cdd:COG4717   305 EELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEEL--QLEELEQEIAAL---LAEA 379

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1071 EVKYANGMIQHSADIQELTRYKAEFFKANDELNQLKSGRESLQAAYD-----ELLRSNAEAQKLLDKEREESEKRVADLH 1145
Cdd:COG4717   380 GVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDeeeleEELEELEEELEELEEELEELREELAELE 459

                         410       420       430
                  ....*....|....*....|....*....|
gi 442623382 1146 ALN---------SNLHDQIEALASKLAVLA 1166
Cdd:COG4717   460 AELeqleedgelAELLQELEELKAELRELA 489
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 2112-2261 1.73e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 43.43  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2112 QPARLESAEVDGTAEVAGGA-PHESAGPSDTGAASASSPQKQSEagESSGSDALKAADDGGDHADGTDNAREAD--EAFA 2188
Cdd:PRK13108  299 EPAELAAAAVASAASAVGPVgPGEPNQPDDVAEAVKAEVAEVTD--EVAAESVVQVADRDGESTPAVEETSEADieREQP 376

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442623382 2189 EETMATGQGEDsqplgndnpnvgtsqsEVSHNQANLGEGNPT-EDSEGADGVSSEGEKQAVGVEEEGREAEATS 2261
Cdd:PRK13108  377 GDLAGQAPAAH----------------QVDAEAASAAPEEPAaLASEAHDETEPEVPEKAAPIPDPAKPDELAV 434
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
693-916 1.75e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  693 EQFDSMRKEVRELTSsnckLMNTTEFQKEQIELLhKNIGTYKQQVTTLEER--TKNYEKTIIKH---EQTVHLLKDEMma 767
Cdd:COG4913   225 EAADALVEHFDDLER----AHEALEDAREQIELL-EPIRELAERYAAARERlaELEYLRAALRLwfaQRRLELLEAEL-- 297

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  768 ahrkhAAADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQSLllnslefikTNLERSEMEgRQRLEQRLDDTVRELA 847
Cdd:COG4913   298 -----EELRAELARLEAELERLEARLDALREELDELEAQIRGNGG---------DRLEQLERE-IERLERELEERERRRA 362

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442623382  848 AQRRHFQEEEEKFRESINEFKRQAETAiklkdeeKQLADKWQAELTSVREELAEKVNKVNELSKKLQEV 916
Cdd:COG4913   363 RLEALLAALGLPLPASAEEFAALRAEA-------AALLEALEEELEALEEALAEAEAALRDLRRELREL 424
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 49-751 1.90e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.52  E-value: 1.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    49 RLAEAEQKKE---ELENKMEDYlvKFTSFELNVNELRTHLDQMSSERVNLMDTIAKGEQTISQLRKEKASVVEERDSMMK 125
Cdd:TIGR02169  202 RLRREREKAEryqALLKEKREY--EGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNK 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   126 VIERQ-QAELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELKENRMESERDMLHKEILLISGDLNKSNAEL 204
Cdd:TIGR02169  280 KIKDLgEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEY 359

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   205 QNIRREHtintMQLQSCLKEKTESLKLMQEQYEQAVKTIGELTSKIemqNDTAFKQNQATEEYVGKLKKELDAKEKLfei 284
Cdd:TIGR02169  360 AELKEEL----EDLRAELEEVDKEFAETRDELKDYREKLEKLKREI---NELKRELDRLQEELQRLSEELADLNAAI--- 429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   285 fKSTESDHLIQREELLQGISEIKrlleEAEEQCAQLTEQMETMKQKH---SAELDEQNKKIQAMEQELASANDLLKQARE 361
Cdd:TIGR02169  430 -AGIEAKINELEEEKEDKALEIK----KQEWKLEQLAADLSKYEQELydlKEEYDRVEKELSKLQRELAEAEAQARASEE 504

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   362 SnlesaicqlAPSAAVASRLIRSDLS--------LTELYSMYAKSSE--------------ELEMRNCeIEQLK------ 413
Cdd:TIGR02169  505 R---------VRGGRAVEEVLKASIQgvhgtvaqLGSVGERYATAIEvaagnrlnnvvvedDAVAKEA-IELLKrrkagr 574

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   414 ---LQLKSIIAEISESAPILEKQNSDY----------------------------------------------------- 437
Cdd:TIGR02169  575 atfLPLNKMRDERRDLSILSEDGVIGFavdlvefdpkyepafkyvfgdtlvvedieaarrlmgkyrmvtlegelfeksga 654

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   438 -------QKMKETNSELLREHDELLQNKL-CLERELERALSTLNHNQNENKKLKQTHTDLSRQVCMLLDELNCI---RAG 506
Cdd:TIGR02169  655 mtggsraPRGGILFSRSEPAELQRLRERLeGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLeqeEEK 734

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   507 VKHVRIQPTRQLPTSESLISDNlvtfssIEELVDRNTYLLNMSRELTELLEASEKNQDKML---LEQSKNHIRKLDARFA 583
Cdd:TIGR02169  735 LKERLEELEEDLSSLEQEIENV------KSELKELEARIEELEEDLHKLEEALNDLEARLShsrIPEIQAELSKLEEEVS 808

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   584 ELEDLLTQKNntvttllskcdrykklyfAAQKKLGQNTVDLDDSNLEPNDSALDTSEQPAANFEESRKLEKRVRQLEQQL 663
Cdd:TIGR02169  809 RIEARLREIE------------------QKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEEL 870

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   664 EgevkkyaslKENYDYYTSEKRKNDalaqeqfdsMRKEVRELTSSNCKLMNTTEFQKEQIELLHKNIGTYKQQVTTLEER 743
Cdd:TIGR02169  871 E---------ELEAALRDLESRLGD---------LKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEE 932


                   ....*...
gi 442623382   744 TKNYEKTI 751
Cdd:TIGR02169  933 LSEIEDPK 940
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
42-470 2.17e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.22  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   42 KNRAAANRLAEAEQKKEELENKMEDYlvkftsfelnvNELRTHLDQMSSERVNLMDTIAKGEQTISQLRKEKAsvveerd 121
Cdd:COG4717    65 KPELNLKELKELEEELKEAEEKEEEY-----------AELQEELEELEEELEELEAELEELREELEKLEKLLQ------- 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  122 smmkvIERQQAELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKEVALELKENRMESERDMLHKEILLISGDLNKSN 201
Cdd:COG4717   127 -----LLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEEL 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  202 AELQNIRREHTINTMQLQSCLKEKTESLKLMQEQYE--QAVKTIGELTSKIEMQN-----DTAFKQNQATEEYVGKLKKE 274
Cdd:COG4717   202 EELQQRLAELEEELEEAQEELEELEEELEQLENELEaaALEERLKEARLLLLIAAallalLGLGGSLLSLILTIAGVLFL 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  275 LDAKEKLFEIFKSTESDHLIQREELLQGISEIKRLleEAEEQCAQLTEQMETMKQKHSaELDEQNKKIQAMEQELASAND 354
Cdd:COG4717   282 VLGLLALLFLLLAREKASLGKEAEELQALPALEEL--EEEELEELLAALGLPPDLSPE-ELLELLDRIEELQELLREAEE 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  355 LLKQARESNLESAICQLAPSAAVASRlirsdlslTELYSMYAKSSEELEMRNcEIEQLKLQLKSIIAEISESAPILEKQN 434
Cdd:COG4717   359 LEEELQLEELEQEIAALLAEAGVEDE--------EELRAALEQAEEYQELKE-ELEELEEQLEELLGELEELLEALDEEE 429

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 442623382  435 --SDYQKMKETNSELLREHDELLQNKLCLERELERALS 470
Cdd:COG4717   430 leEELEELEEELEELEEELEELREELAELEAELEQLEE 467
PTZ00121 PTZ00121
MAEBL; Provisional
 39-479 2.19e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   39 EYCKNRAAANRLAEAEQKKEELENKMEDYLVKFTSFELNVNELRTHLDQMSSERVNLMDTIAKGEQTISQLRKEKASVVE 118
Cdd:PTZ00121 1473 DEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELK 1552

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  119 ERDSMMKVIERQQAELERLKQDLHTYQ----QQLSSAIAAKCEAIARVDEIQSKEVALELK---ENRMESERDMLHKEIL 191
Cdd:PTZ00121 1553 KAEELKKAEEKKKAEEAKKAEEDKNMAlrkaEEAKKAEEARIEEVMKLYEEEKKMKAEEAKkaeEAKIKAEELKKAEEEK 1632

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  192 LISGDLNKSNAE----LQNIRREHTINTMQLQScLKEKTESLKLMQEQYEQAvktigeltSKIEMQNDTAFKQNQATEEY 267
Cdd:PTZ00121 1633 KKVEQLKKKEAEekkkAEELKKAEEENKIKAAE-EAKKAEEDKKKAEEAKKA--------EEDEKKAAEALKKEAEEAKK 1703

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  268 VGKLKKELDAKEKLFEIFKSTESDHLIQREELLQGISEIKRLLEEAEEQCAQLTEQMETMKQKHSAELDEQNKKIQAMEQ 347
Cdd:PTZ00121 1704 AEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEE 1783

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  348 ELASANDLLKQARESNLESAicqLAPSAAVASRLIRSDLSLTELYSMYAKSSEEL-EMRNCEIEQLKLQLKSIIAEISES 426
Cdd:PTZ00121 1784 ELDEEDEKRRMEVDKKIKDI---FDNFANIIEGGKEGNLVINDSKEMEDSAIKEVaDSKNMQLEEADAFEKHKFNKNNEN 1860

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 442623382  427 APILEKqNSDYQKMKETNSELLREHDELLQNKLCLERELERALSTLNHNQNEN 479
Cdd:PTZ00121 1861 GEDGNK-EADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREIPNNNMAGKNN 1912
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 826-1623 2.33e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.52  E-value: 2.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   826 RSEMEGRQRLEQRLDDTVRELAAQRRHFQEEEEKFRE--SINEFKRQAETAIKLKDEEKQLADKWQ--AELTSVREELAE 901
Cdd:TIGR02169  176 LEELEEVEENIERLDLIIDEKRQQLERLRREREKAERyqALLKEKREYEGYELLKEKEALERQKEAieRQLASLEEELEK 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   902 KVNKVNELSKKLQ--EVLTPTLNDNPITAANKRAREFELKLDQATVEIESLTKELAKTREHGEQFYKMSQSAESEIKRLH 979
Cdd:TIGR02169  256 LTEEISELEKRLEeiEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLL 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   980 ELHGELVAKQEEEIKKLRSseaeLKTRISDLEAEAMLSNVTEQSKtvnqSGQLKSAQDDLKSLLEKLTEANCTIRTLRSE 1059
Cdd:TIGR02169  336 AEIEELEREIEEERKRRDK----LTEEYAELKEELEDLRAELEEV----DKEFAETRDELKDYREKLEKLKREINELKRE 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1060 NTSLVESLNAAEvkyangmiqhsadiQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSNAEAQKLLDKEREESEK 1139
Cdd:TIGR02169  408 LDRLQEELQRLS--------------EELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYD 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1140 RVADLHALNsnlhDQIEALASKLAVLASQSQNPNSSLNESAmdgdqslnasgltAAEE--GRNNEQLLKIIKFLRKEKDL 1217
Cdd:TIGR02169  474 LKEEYDRVE----KELSKLQRELAEAEAQARASEERVRGGR-------------AVEEvlKASIQGVHGTVAQLGSVGER 536

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1218 FAAKLDIlkAENARL---------ISEHAIQqkkvdelngYLNQERAKSQTdVVSANKHEEVLRkietlnaitDSNRILR 1288
Cdd:TIGR02169  537 YATAIEV--AAGNRLnnvvveddaVAKEAIE---------LLKRRKAGRAT-FLPLNKMRDERR---------DLSILSE 595

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1289 EERNALTLRVAELTDRISSVEKELF--PLQCSNKElTSKIEEINVENTSLRTEAIkwrQRANALVEKSNRNPEEFKRLQA 1366
Cdd:TIGR02169  596 DGVIGFAVDLVEFDPKYEPAFKYVFgdTLVVEDIE-AARRLMGKYRMVTLEGELF---EKSGAMTGGSRAPRGGILFSRS 671

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1367 EREHLAKLltaekelnkkqSDELTVLKQRMNTEIPMLNKQMQILDEARKKQVDEftnlkqnnTRQTQDIMELKNRLLQKE 1446
Cdd:TIGR02169  672 EPAELQRL-----------RERLEGLKRELSSLQSELRRIENRLDELSQELSDA--------SRKIGEIEKEIEQLEQEE 732

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1447 EELLKANEELETKDKTIADketkelqlrklakrykdfyiglqsqgggtesaaELEKVRSELEEVNNQLRALKDEHEKITK 1526
Cdd:TIGR02169  733 EKLKERLEELEEDLSSLEQ---------------------------------EIENVKSELKELEARIEELEEDLHKLEE 779

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1527 ECDEVKKRTEPEtdtsaIRQEYKAKLDKLvvDLTVARTDLVNQETTFAGTKSSYDETIARLE-KELQENIAANKDINQRL 1605
Cdd:TIGR02169  780 ALNDLEARLSHS-----RIPEIQAELSKL--EEEVSRIEARLREIEQKLNRLTLEKEYLEKEiQELQEQRIDLKEQIKSI 852

                          810
                   ....*....|....*...
gi 442623382  1606 TRENESLHMRINQLTRQL 1623
Cdd:TIGR02169  853 EKEIENLNGKKEELEEEL 870
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 216-976 2.44e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 43.17  E-value: 2.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   216 MQLQSCLKEKTESLKLMQEQYEQAVKTIGEL---TSKIEMQNDTAFKQNQateeyvgKLKKELDAKEKLFEIFKST---- 288
Cdd:pfam05483   95 VSIEAELKQKENKLQENRKIIEAQRKAIQELqfeNEKVSLKLEEEIQENK-------DLIKENNATRHLCNLLKETcars 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   289 ---ESDHLIQREELLQGISEIKRLLEEAEEQCAQLTEQMETMKQKHSAELDEQNKKIQAMEQELasandllkqaresnle 365
Cdd:pfam05483  168 aekTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEY---------------- 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   366 saicqlapsaavasrlirsdlsltelysmyaksSEELEMRNCEIEQLKLQLKSIIAEISESAPILEKQNSDYQKMKETNS 445
Cdd:pfam05483  232 ---------------------------------KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTK 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   446 ELLREHDELLQNKLCLERELERALSTLNHNQNENKKLKQTHTDLSRQVCMLLDElnciragvKHVRIQPTRQLPTSESLI 525
Cdd:pfam05483  279 LQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEE--------KEAQMEELNKAKAAHSFV 350

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   526 SDNL-VTFSSIEELVDRNTYLLNMSRELTELLEASEKNQDKMLLEQSKNHIRKlDARFAELEDLLTQKNntvtTLLSKCD 604
Cdd:pfam05483  351 VTEFeATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNK-EVELEELKKILAEDE----KLLDEKK 425

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   605 RYKKLYFAAQKKLGQNTVDLDDSNLEPND-----SALDTSEQpaanfeesrKLEKRVRQLEQQLEGEVKKYASLKENYDY 679
Cdd:pfam05483  426 QFEKIAEELKGKEQELIFLLQAREKEIHDleiqlTAIKTSEE---------HYLKEVEDLKTELEKEKLKNIELTAHCDK 496

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   680 YTSEKRKndaLAQEQFDSmrkeVRELTSSNCKLMNTtefqKEQIELLHKNIGTYKQQVTTLEERTKNYEKTII------- 752
Cdd:pfam05483  497 LLLENKE---LTQEASDM----TLELKKHQEDIINC----KKQEERMLKQIENLEEKEMNLRDELESVREEFIqkgdevk 565

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   753 ----KHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSSRLQIEKETYHREQQSQSLLLNSLEFIKTNLERSE 828
Cdd:pfam05483  566 ckldKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELEL 645

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   829 MEGRQRLEQRLDDTVRELAAQRRhfqeEEEKFRESINEFKRQAETAIKLKDEEKQLADKWQAELTSVREELAEKVNKVNE 908
Cdd:pfam05483  646 ASAKQKFEEIIDNYQKEIEDKKI----SEEKLLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIE 721

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442623382   909 lsKKLQEVltpTLNDNPITAANKRAREFELKLDQATVEIESLTKELAKTREHGEQFYKMSQSAESEIK 976
Cdd:pfam05483  722 --ERDSEL---GLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTAILK 784
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 720-916 2.60e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.44  E-value: 2.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  720 KEQIELLHKNIGTYKQQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAAHRKHAAADAEAQSLRQENRILRDTSSRLqiE 799
Cdd:COG4942    33 QQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAEL--L 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  800 KETYHREQQSQSLLL----NSLEFIK--------TNLERSEMEGRQRLEQRLDDTVRELAAQRrhfqeeeEKFRESINEF 867
Cdd:COG4942   111 RALYRLGRQPPLALLlspeDFLDAVRrlqylkylAPARREQAEELRADLAELAALRAELEAER-------AELEALLAEL 183

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 442623382  868 KRQAETAIKLKDEEKQLADKWQAELTSVREELAEKVNKVNELSKKLQEV 916
Cdd:COG4942   184 EEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARL 232
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1268-1478 2.65e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.44  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1268 EEVLRKIETLNAITDSnriLREERNALTLRVAELTDRISSVEKELFPLQCSNKELTSKIEEINVENTSLRTEAIKWRQRA 1347
Cdd:COG4942    30 EQLQQEIAELEKELAA---LKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEEL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1348 NALVEK--------------SNRNPEEFKRLQAEREHLAKLLTAEKELNKKQSDELTVLKQRmnteipmLNKQMQILDEA 1413
Cdd:COG4942   107 AELLRAlyrlgrqpplalllSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAE-------LEAERAELEAL 179

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442623382 1414 RKKQVDEFTNLKQNNTRQTQDIMELKNRLLQKEEELLKANEELETKDKTIADKETKELQLRKLAK 1478
Cdd:COG4942   180 LAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244
PRK01156 PRK01156
chromosome segregation protein; Provisional
 9-571 2.80e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 42.97  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    9 LNNILQPDELK---LVPEDVQKKLSEYINNFSDEYCKNRAAANRLAEAEQKKEELENKMEDYLVKFTSFELNVNELRTHL 85
Cdd:PRK01156  155 LDEILEINSLErnyDKLKDVIDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDY 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   86 DQMSSERVNLM---DTIAKGEQTISQLRKEKASVVEERDSMMKVIERQQA--------------ELERLKQDLHTYQQQL 148
Cdd:PRK01156  235 NNLKSALNELSsleDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKiindpvyknrnyinDYFKYKNDIENKKQIL 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  149 S---SAIAAKCEAIARVDEIQSKEVALELKENRMESerdmLHKEILLISGDLNKSNAELQNI------RREHTINTMQLQ 219
Cdd:PRK01156  315 SnidAEINKYHAIIKKLSVLQKDYNDYIKKKSRYDD----LNNQILELEGYEMDYNSYLKSIeslkkkIEEYSKNIERMS 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  220 SclkEKTESLKLMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQAteeyVGKLKKELDAKEKLFEIFkSTESDHLIQREEL 299
Cdd:PRK01156  391 A---FISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQR----IRALRENLDELSRNMEML-NGQSVCPVCGTTL 462

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  300 lqGISEIKRLLEEAEEQCAQLTEQMETMKQKHSAeLDEQNKKIQAMEQELASANDLLKQARESNLESAICQLAPSAAVAS 379
Cdd:PRK01156  463 --GEEKSNHIINHYNEKKSRLEEKIREIEIEVKD-IDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKIN 539

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  380 RLIRSDLSLTELYSMY-AKSSEELEMRNCE-------------------IEQLKLQLKSIIA---EISESAPILEKQNSD 436
Cdd:PRK01156  540 ELKDKHDKYEEIKNRYkSLKLEDLDSKRTSwlnalavislidietnrsrSNEIKKQLNDLESrlqEIEIGFPDDKSYIDK 619

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  437 YQKMKETNSELLREHDELLQNKLCLERELERALSTLNHNQNENKKLKQTHTDLSRQVCMLLDELNCIRAGVKHVRIQPTR 516
Cdd:PRK01156  620 SIREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRAR 699

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 442623382  517 QLPTSESLISDN---LVTFSSIEELVDRNTYLLNMSRELTELLEASEKNQDKMLLEQS 571
Cdd:PRK01156  700 LESTIEILRTRInelSDRINDINETLESMKKIKKAIGDLKRLREAFDKSGVPAMIRKS 757
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 303-1463 2.91e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 43.12  E-value: 2.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   303 ISEIKRLLEEAEEQCAQLTEQMETMKQKHsAELDEQNKKIQAMEQEL-------ASANDLLKQARE-----SNLESAICQ 370
Cdd:TIGR01612  560 IHEIKKELEEENEDSIHLEKEIKDLFDKY-LEIDDEIIYINKLKLELkekikniSDKNEYIKKAIDlkkiiENNNAYIDE 638

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   371 LAPSA--AVASRLIRSDlsltELYSMYakSSEELEMRNCEIEQLKLQLKSIIAEISESapilekQNSDYQKMKETNSELL 448
Cdd:TIGR01612  639 LAKISpyQVPEHLKNKD----KIYSTI--KSELSKIYEDDIDALYNELSSIVKENAID------NTEDKAKLDDLKSKID 706

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   449 REHDELlQNklcLERE-LERALSTLNHNQNENKKL-----KQTHTDLSRqvcmlldELNCIRAGVKHVRIQPTRQLpTSE 522
Cdd:TIGR01612  707 KEYDKI-QN---METAtVELHLSNIENKKNELLDIiveikKHIHGEINK-------DLNKILEDFKNKEKELSNKI-NDY 774

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   523 SLISDNLVTFSS-IEELvdRNTYLLNMSRELTELLEASEKnqdkmlLEQSKNHIRKLDARFAELEDLLTQKNNTVTTLLS 601
Cdd:TIGR01612  775 AKEKDELNKYKSkISEI--KNHYNDQINIDNIKDEDAKQN------YDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLN 846

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   602 KCDRYKKLYFAAQKKLG----QNTVDLDDSNLEPNDSALDTSEQpaaNFEESRKLekrVRQLEQQLEGEVKKYASLKENY 677
Cdd:TIGR01612  847 KVDKFINFENNCKEKIDseheQFAELTNKIKAEISDDKLNDYEK---KFNDSKSL---INEINKSIEEEYQNINTLKKVD 920

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   678 DYYTSEKRKNDALaqEQFDSMRKEVRELTSSNCKLM---------------NT-----TEFQKEQIEL------------ 725
Cdd:TIGR01612  921 EYIKICENTKESI--EKFHNKQNILKEILNKNIDTIkesnlieksykdkfdNTlidkiNELDKAFKDAslndyeaknnel 998

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   726 ------LHKNIGTYK-----QQVTTLEERTKNYEKTIIKHEQTVHLLKdemMAAHRKHAAADAEAQSLRQENRILRDTSS 794
Cdd:TIGR01612  999 ikyfndLKANLGKNKenmlyHQFDEKEKATNDIEQKIEDANKNIPNIE---IAIHTSIYNIIDEIEKEIGKNIELLNKEI 1075

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   795 RLQIEKE-TYHREQQSQSLLLNSLEFIK------TNLERSEMEGRQRLEQRLDDTVRELAAQRRHFQEEEEKFRESINEF 867
Cdd:TIGR01612 1076 LEEAEINiTNFNEIKEKLKHYNFDDFGKeenikyADEINKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDEIKAQINDL 1155

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   868 KRQAETAIKlKDEEKQLADKWQAELTSV--REELAEKVNK-VNELSK--KLQEVLTPTLNDNpITAANKRAREFELKLDQ 942
Cdd:TIGR01612 1156 EDVADKAIS-NDDPEEIEKKIENIVTKIdkKKNIYDEIKKlLNEIAEieKDKTSLEEVKGIN-LSYGKNLGKLFLEKIDE 1233

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   943 ATVEIESLTKELAKTREHGEQFYKMSQSAESeikrlhELHGELVAKQEEEIKKLRSSEAELKTRISDLEAEAmLSNVTEQ 1022
Cdd:TIGR01612 1234 EKKKSEHMIKAMEAYIEDLDEIKEKSPEIEN------EMGIEMDIKAEMETFNISHDDDKDHHIISKKHDEN-ISDIREK 1306

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1023 SKTVNQSGQLKSAQDDLKSLLEK-LTEA---NCTIRTLRSENTSLVESLNAAEVKYAngmiqhsadIQELTRYKAEFFKA 1098
Cdd:TIGR01612 1307 SLKIIEDFSEESDINDIKKELQKnLLDAqkhNSDINLYLNEIANIYNILKLNKIKKI---------IDEVKEYTKEIEEN 1377

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1099 NDELNqlksgreslqaayDELLRSNAEAQKLLDKEREESEKRVADLHALNSNLHDQIEALA-SKLAVLASQSQNPNSSLN 1177
Cdd:TIGR01612 1378 NKNIK-------------DELDKSEKLIKKIKDDINLEECKSKIESTLDDKDIDECIKKIKeLKNHILSEESNIDTYFKN 1444

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1178 ESAMDGDQSLNASGLTAAEegrNNEQLLKIIKFLRKEKDLfAAKLDILKA--ENARLISEHAIQQKKVDELNGYLNQERA 1255
Cdd:TIGR01612 1445 ADENNENVLLLFKNIEMAD---NKSQHILKIKKDNATNDH-DFNINELKEhiDKSKGCKDEADKNAKAIEKNKELFEQYK 1520

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1256 KSQTDVVsaNKHEEVLRKIETLNAITDSNRILRE---ERNALTLRVAELTDRISSVEKELFPLQ---CSNKELTSKIEEI 1329
Cdd:TIGR01612 1521 KDVTELL--NKYSALAIKNKFAKTKKDSEIIIKEikdAHKKFILEAEKSEQKIKEIKKEKFRIEddaAKNDKSNKAAIDI 1598

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1330 NVENTSLRTEAIKwrqrANALVEKSNRNPEEFKRLQAEREHLAkLLTAEKELnKKQSDELTVLKQRMNTeipMLNKQMQI 1409
Cdd:TIGR01612 1599 QLSLENFENKFLK----ISDIKKKINDCLKETESIEKKISSFS-IDSQDTEL-KENGDNLNSLQEFLES---LKDQKKNI 1669

                         1210      1220      1230      1240      1250
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 442623382  1410 ldEARKKQVDEF-TNLKQNNTRQTQDIMELKNRLLQKEEELLKAN-EELETKDKTI 1463
Cdd:TIGR01612 1670 --EDKKKELDELdSEIEKIEIDVDQHKKNYEIGIIEKIKEIAIANkEEIESIKELI 1723
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
969-1612 3.24e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.98  E-value: 3.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  969 QSAESEIKRLHELHGELVAKQE-----EEIKKLRSSEAELKTRISDLEAEAMLSNVTEQSKTVNQsgqLKSAQDDLKSLL 1043
Cdd:COG4913   228 DALVEHFDDLERAHEALEDAREqiellEPIRELAERYAAARERLAELEYLRAALRLWFAQRRLEL---LEAELEELRAEL 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1044 EKLTEAnctIRTLRSENTSLVESLNAAEVKYANgmiqhsADIQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSN 1123
Cdd:COG4913   305 ARLEAE---LERLEARLDALREELDELEAQIRG------NGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPL 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1124 AEAQKLLDKEREESEKRVADLHALNSNLHDQIEALASKLAVLASQSQnpnSSLNEsamdgdqslnasgLTAAEEGRNN-- 1201
Cdd:COG4913   376 PASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELR---ELEAE-------------IASLERRKSNip 439

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1202 EQLLKIIKFLR-----KEKDL-FAAKLDILKAENAR----------------LISEHAIQQ--KKVDELNGylnqeRAKS 1257
Cdd:COG4913   440 ARLLALRDALAealglDEAELpFVGELIEVRPEEERwrgaiervlggfaltlLVPPEHYAAalRWVNRLHL-----RGRL 514

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1258 QTDVVSANKHEE---------VLRKIET--------LNAIT---------DSNRILREERNALTL--------------- 1296
Cdd:COG4913   515 VYERVRTGLPDPerprldpdsLAGKLDFkphpfrawLEAELgrrfdyvcvDSPEELRRHPRAITRagqvkgngtrhekdd 594

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1297 --RVAEL-------TDRISSVEKELfplqcsnKELTSKIEEINVENTSLRTEAIKWRQRANALVEKSNRNPEEFKRLQAE 1367
Cdd:COG4913   595 rrRIRSRyvlgfdnRAKLAALEAEL-------AELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAE 667

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1368 REHLAklLTAEKELNKKQSDELTVLKQRmnteipmlnkqmqiLDEARKkqvdEFTNLKQNNTRQTQDIMELKNRLLQKEE 1447
Cdd:COG4913   668 REIAE--LEAELERLDASSDDLAALEEQ--------------LEELEA----ELEELEEELDELKGEIGRLEKELEQAEE 727

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1448 ELLKANEELETkdktiADKETKELQLRKLAKRYKdfyiglqsQGGGTESAAEL-EKVRSELEEVNNQLRALKDEHEKITK 1526
Cdd:COG4913   728 ELDELQDRLEA-----AEDLARLELRALLEERFA--------AALGDAVERELrENLEERIDALRARLNRAEEELERAMR 794

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1527 E-CDEVKKRTEPETDTSAIRQEYKAKLDKLVvdltvaRTDLVNQETTFAGT-KSSYDETIARLEKELQENIaanKDINQR 1604
Cdd:COG4913   795 AfNREWPAETADLDADLESLPEYLALLDRLE------EDGLPEYEERFKELlNENSIEFVADLLSKLRRAI---REIKER 865


                  ....*...
gi 442623382 1605 LTRENESL 1612
Cdd:COG4913   866 IDPLNDSL 873
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 721-1018 4.10e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 42.50  E-value: 4.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   721 EQIELLHKNIGTYKQQVTTLEERTKN-------YEKTIIKHEQTVHLLKDEMMAAHRKHAAadaEAQSLRQENRILRDTS 793
Cdd:pfam10174  408 EQLRDKDKQLAGLKERVKSLQTDSSNtdtalttLEEALSEKERIIERLKEQREREDRERLE---ELESLKKENKDLKEKV 484

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   794 SRLQI---EKETYHREQQSQSLLLNSLEFIKTNLERSeMEGrqRLEQRLDDTVR-ELAAQRRHFQEEEEKFRESINEFKR 869
Cdd:pfam10174  485 SALQPeltEKESSLIDLKEHASSLASSGLKKDSKLKS-LEI--AVEQKKEECSKlENQLKKAHNAEEAVRTNPEINDRIR 561

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   870 QAETAIKLKDEEkqlADKWQAELTSVREELAEKVNKVNELSKKLQEVLTPTLN---DNPITAANKRAREFELKLDQATVE 946
Cdd:pfam10174  562 LLEQEVARYKEE---SGKAQAEVERLLGILREVENEKNDKDKKIAELESLTLRqmkEQNKKVANIKHGQQEMKKKGAQLL 638

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442623382   947 IESLTKELAKTREHGEQfykmsqsaeseikRLHELHGELV-AKQEEEIKKLRSSEaelkTRISDLEAEAMLSN 1018
Cdd:pfam10174  639 EEARRREDNLADNSQQL-------------QLEELMGALEkTRQELDATKARLSS----TQQSLAEKDGHLTN 694
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1096-1311 4.22e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.06  E-value: 4.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1096 FKANDELNQLKSGRESLQAAYDEL---LRSNAEAQKLLDKEREESEKRVADLHALNSNLHDQIEALASKLAVLASQSQNP 1172
Cdd:COG4942    16 AAQADAAAEAEAELEQLQQEIAELekeLAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAEL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1173 NSSLNESAMDGDQSLNA-------SGLTAAEEGRNNEQLLKIIKFLRKEKDLFAAKLDILKAENARLISEHAIQQKKVDE 1245
Cdd:COG4942    96 RAELEAQKEELAELLRAlyrlgrqPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAE 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442623382 1246 LNGYLNQERAKSQTDVVSANKHEEVLRKIET-LNAITDSNRILREERNALTLRVAELTDRISSVEKE 1311
Cdd:COG4942   176 LEALLAELEEERAALEALKAERQKLLARLEKeLAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 1268-1604 4.33e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.47  E-value: 4.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1268 EEVLRKIET-LNAITDSNRILREERNALTLRVAELTDRISSVEKELFPLQCSNKELTSKIEEINVENTSLRTEAIKWRQR 1346
Cdd:pfam01576   74 EEILHELESrLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKE 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1347 ANALVEKSNrnpeEFKRLQAEREHLAKLLTaekELNKKQSDELTVLKQRMNTEipmlNKQMQILDEARKKQVDEFTNLKQ 1426
Cdd:pfam01576  154 RKLLEERIS----EFTSNLAEEEEKAKSLS---KLKNKHEAMISDLEERLKKE----EKGRQELEKAKRKLEGESTDLQE 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1427 NNTRQTQDIMELKNRLLQKEEEL--LKANEELETKDKTIADKETKELQlRKLAKRYKDFYIGLQSQGGGTES----AAEL 1500
Cdd:pfam01576  223 QIAELQAQIAELRAQLAKKEEELqaALARLEEETAQKNNALKKIRELE-AQISELQEDLESERAARNKAEKQrrdlGEEL 301

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1501 EKVRSELEEVNNQLRALKDEHEKITKECDEVKKRTEPETDT-----SAIRQEYKAKLDKLVVDLTVARTDLVNQETtfag 1575
Cdd:pfam01576  302 EALKTELEDTLDTTAAQQELRSKREQEVTELKKALEEETRSheaqlQEMRQKHTQALEELTEQLEQAKRNKANLEK---- 377

                          330       340
                   ....*....|....*....|....*....
gi 442623382  1576 TKSSYDETIARLEKELQENIAANKDINQR 1604
Cdd:pfam01576  378 AKQALESENAELQAELRTLQQAKQDSEHK 406
PRK01156 PRK01156
chromosome segregation protein; Provisional
 1083-1536 5.56e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 42.20  E-value: 5.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1083 ADIQELTRYKAEFFKANDELNQLKSGRESLQAAYDELLRSNAEAQKLLDKEREESEKRVADLHALNSnLHDQIEALASKL 1162
Cdd:PRK01156  180 AEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSS-LEDMKNRYESEI 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1163 AVLASQSQNPNSSLNESAmDGDQSLNASGLTAAEEGRNneqllKIIKFLRKEKDLFAAKlDILKAENARLISEHAIQQKK 1242
Cdd:PRK01156  259 KTAESDLSMELEKNNYYK-ELEERHMKIINDPVYKNRN-----YINDYFKYKNDIENKK-QILSNIDAEINKYHAIIKKL 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1243 VDELNGYLNQERAKSQTDVVS---------ANKHEEVLRKIETLNAITDSNRILREERNAL---TLRVAELTDriSSVEK 1310
Cdd:PRK01156  332 SVLQKDYNDYIKKKSRYDDLNnqilelegyEMDYNSYLKSIESLKKKIEEYSKNIERMSAFiseILKIQEIDP--DAIKK 409

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1311 ELFPLQCSNKELTSKIEEINVENTSLRTEAIKWRQRANALvEKSNRNPEEFKRLQAER-EHLAKLLTAEKELNKKQSDEL 1389
Cdd:PRK01156  410 ELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEML-NGQSVCPVCGTTLGEEKsNHIINHYNEKKSRLEEKIREI 488

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 1390 TVLKQRMNTEIPMLNKQMQILDEARKKQVDEFTNLKQNNTRQTQDIMELKNRLLQKEeelLKANEeletkdktiADKETK 1469
Cdd:PRK01156  489 EIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKH---DKYEE---------IKNRYK 556

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442623382 1470 ELQLRKLAKRYKDfYIGLQSQgggtESAAELEKVRSELEEVNNQLRALKDEHEKITKECDEVKKRTE 1536
Cdd:PRK01156  557 SLKLEDLDSKRTS-WLNALAV----ISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYID 618
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1352-1618 6.17e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 42.13  E-value: 6.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1352 EKSNRNPEEFKRLQAEREHLAKLLtaekelnkKQSDELTVLKQRMNTEIPMLNKQMQILDEARKKQVDEFTNLKQNNTRQ 1431
Cdd:pfam12128  214 PKSRLNRQQVEHWIRDIQAIAGIM--------KIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETS 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1432 TqdimELKNRLLQKEEELL----KANEELETKDKTIADKETKELQLRKLAKRYKDfyIGLQSQGGGTEsaaELEKVRSEL 1507
Cdd:pfam12128  286 A----ELNQLLRTLDDQWKekrdELNGELSAADAAVAKDRSELEALEDQHGAFLD--ADIETAAADQE---QLPSWQSEL 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1508 EEVNNQLRALKDEHEKITKECD--EVKKRTEPETDTSAIRQEYKAKLDKLVVDLTVARTDLVNQETTFAGTKSSYDETIA 1585
Cdd:pfam12128  357 ENLEERLKALTGKHQDVTAKYNrrRSKIKEQNNRDIAGIKDKLAKIREARDRQLAVAEDDLQALESELREQLEAGKLEFN 436

                          250       260       270
                   ....*....|....*....|....*....|....
gi 442623382  1586 RLEKELQENIA-ANKDINQRLTRENESLHMRINQ 1618
Cdd:pfam12128  437 EEEYRLKSRLGeLKLRLNQATATPELLLQLENFD 470
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2043-2297 6.97e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 6.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2043 ATASASTQENNQSQAITSGSGESSNPVTLPQAEASNWKQAAASTSTAAARRNESSVEIVSSPqvsnfceQPARLESAEVD 2122
Cdd:PHA03307  159 PAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSP-------APAPGRSAADD 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2123 GTAEVAGGAPHESAG-----------PSDTGAASASSPqKQSEAGESSGSDALKAADDGGDHADGTDNAREADEAFAEET 2191
Cdd:PHA03307  232 AGASSSDSSSSESSGcgwgpenecplPRPAPITLPTRI-WEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPS 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382 2192 MATGQGEDSqPLGNDNPNVGTSQSEVSHnqanlGEGNPTEDSEGADGVSSEGEKQAVGveeeGREAEATSPSENTRFRTL 2271
Cdd:PHA03307  311 SPRASSSSS-SSRESSSSSTSSSSESSR-----GAAVSPGPSPSRSPSPSRPPPPADP----SSPRKRPRPSRAPSSPAA 380

                         250       260
                  ....*....|....*....|....*.
gi 442623382 2272 RSAVPTRRGHRAMRGGSPNSQNRPQR 2297
Cdd:PHA03307  381 SAGRPTRRRARAAVAGRARRRDATGR 406
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 73-909 7.27e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 41.96  E-value: 7.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382    73 SFELNVNELRTHLDQMSSERVNLM---DTIAKGEQTISQLRKEKASVVEERDSMMKVIERQQAELERLKQDLHTYQQQLS 149
Cdd:TIGR00606  242 SYENELDPLKNRLKEIEHNLSKIMkldNEIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRTVREKEREL 321

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   150 SAIAAKCEAIAR-VDEIQSKEVALELKENRMESERDMLHKEILLISGDL--NKSNAELQNIRREHTINtmqlqsclKEKT 226
Cdd:TIGR00606  322 VDCQRELEKLNKeRRLLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIqsLATRLELDGFERGPFSE--------RQIK 393

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   227 ESLKLMQEQYEQAVKTIGELTSkiEMQNDTAFKQNQATEEYVgKLKKELDAKEKLFEIFKSTESDHLIQREELLQGISEI 306
Cdd:TIGR00606  394 NFHTLVIERQEDEAKTAAQLCA--DLQSKERLKQEQADEIRD-EKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSS 470

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   307 KRLLEEAEeqcaqlteqmETMKQKHSAELDEQNKKIQAMEQELASAndllkQARESNLESAICQLAPSAAvasRLIRSDL 386
Cdd:TIGR00606  471 DRILELDQ----------ELRKAERELSKAEKNSLTETLKKEVKSL-----QNEKADLDRKLRKLDQEME---QLNHHTT 532

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   387 SLTELYSMYAKSSEELEMRNCEIEQLKLQLKSIIAEISESaPILEKQNSDYQKMKETNSELLREhdellqnklcLERELE 466
Cdd:TIGR00606  533 TRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPNK-KQLEDWLHSKSKEINQTRDRLAK----------LNKELA 601

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   467 RALSTLNHNQNENKKLKQTHTDLSRQvcmLLDELNCIRAGVKHVRIQPTRQLPTSE--SLISDNLVTFSSIEELVDRNTY 544
Cdd:TIGR00606  602 SLEQNKNHINNELESKEEQLSSYEDK---LFDVCGSQDEESDLERLKEEIEKSSKQraMLAGATAVYSQFITQLTDENQS 678

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   545 LLNMSREL----TELLEASEKNQDKML-----LEQSKNHIRKLDARFAELEDLLTQKNNTVttllskcDRYKKLYFAAQK 615
Cdd:TIGR00606  679 CCPVCQRVfqteAELQEFISDLQSKLRlapdkLKSTESELKKKEKRRDEMLGLAPGRQSII-------DLKEKEIPELRN 751

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   616 KLGQNTVDLDD--SNLEPNDSALDTSEQPAANFEESRKLEKRVRQLEQQLEGEVKKYASLKE-----NYDYYTSEKRKND 688
Cdd:TIGR00606  752 KLQKVNRDIQRlkNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAklqgsDLDRTVQQVNQEK 831

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   689 ALAQEQFDSMRKEVREltssNCKLMNTTEFQKEQIELLHKNIGTYKQQVTTLEERTKNYEKTIIKHEQTVHLLKDEMMAA 768
Cdd:TIGR00606  832 QEKQHELDTVVSKIEL----NRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDA 907

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   769 HRKHAAADAEAQSLRQENRILrdtSSRLQIEKETYHREQQSQSLLLNSLEFIKTNLERSEMEGRQRLEQRLDDTVRELAA 848
Cdd:TIGR00606  908 KEQDSPLETFLEKDQQEKEEL---ISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETELNTVNA 984

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442623382   849 QRRHFQEEEEKFRESINEFKRQAETAiklKDEEKQLAD-----KWQAELTSVREELAEKVNKVNEL 909
Cdd:TIGR00606  985 QLEECEKHQEKINEDMRLMRQDIDTQ---KIQERWLQDnltlrKRENELKEVEEELKQHLKEMGQM 1047
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
568-896 8.40e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 8.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  568 LEQSKNHIRKLDARFAELEDLLtqknNTVTTLLSKCDRYKKLYF------AAQKKLGQNTVDLDDsnLEPNDSALDTSEQ 641
Cdd:COG4913   619 LAELEEELAEAEERLEALEAEL----DALQERREALQRLAEYSWdeidvaSAEREIAELEAELER--LDASSDDLAALEE 692

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  642 paanfeESRKLEKRVRQLEQQLEGEVKKYASLKENYDYYTSEKRKndalAQEQFDSMRKEVRELTSSNCKLMNTTEFQKE 721
Cdd:COG4913   693 ------QLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDE----LQDRLEAAEDLARLELRALLEERFAAALGDA 762

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  722 QIELLHKNIGtykQQVTTLEERTKNYEKTIIKheqtvhllkdeMMAAHRKH-----AAADAEAQSLRQENRILRdtssRL 796
Cdd:COG4913   763 VERELRENLE---ERIDALRARLNRAEEELER-----------AMRAFNREwpaetADLDADLESLPEYLALLD----RL 824

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  797 QIEKETYHREQQSQSLLLNSLEFI---KTNLERSEMEGRQRLE------QRLD---DTVRELAAQRRHFQEEEEkFRESI 864
Cdd:COG4913   825 EEDGLPEYEERFKELLNENSIEFVadlLSKLRRAIREIKERIDplndslKRIPfgpGRYLRLEARPRPDPEVRE-FRQEL 903

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 442623382  865 NEFKRQAETAI----------------KLKDEEKQLADKWQAELTSVR 896
Cdd:COG4913   904 RAVTSGASLFDeelsearfaalkrlieRLRSEEEESDRRWRARVLDVR 951
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 823-1487 8.48e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 41.64  E-value: 8.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   823 NLERSEMEGRQRLEQRLDDTVRELAAQRRHFQEEEEKFRESINEFKRQAETAIKLKDEEKQ-LADKWQAELTSVREELAE 901
Cdd:pfam15921  131 DIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSiLVDFEEASGKKIYEHDSM 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   902 KV----NKVNELSKKLQEVLTPT---------LNDNPITAANKRAREFELKLDQAT-----------VEIESLTKELAKT 957
Cdd:pfam15921  211 STmhfrSLGSAISKILRELDTEIsylkgrifpVEDQLEALKSESQNKIELLLQQHQdrieqliseheVEITGLTEKASSA 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   958 REHGEQFYKMSQSAESEIKRLHELHGELVAKQEEEIKKLRSSEAELK----TRISDLEAEAMLSNV------TEQSKTVN 1027
Cdd:pfam15921  291 RSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKrmyeDKIEELEKQLVLANSeltearTERDQFSQ 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1028 QSGQLksaQDDLKSLLEKLTEANCTIRTLRSENTSLVESLNAaevkyangmiqHSADIQELTRykaEFFKANDELNQLKS 1107
Cdd:pfam15921  371 ESGNL---DDQLQKLLADLHKREKELSLEKEQNKRLWDRDTG-----------NSITIDHLRR---ELDDRNMEVQRLEA 433

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1108 GRESLQAAYDELLRSNAEAQKLLDKEREESEKRVADLHALNSNLHDQIEALASKLAVLASqSQNPNSSLNESAMDGDQSL 1187
Cdd:pfam15921  434 LLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLES-SERTVSDLTASLQEKERAI 512

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1188 NASGLTAAEEGRNNEQLLKIIKFLRKEKDLF---AAKLDILKAENARLISEHAIQQKKVDELNGYLNQE-RAKSQTDVVS 1263
Cdd:pfam15921  513 EATNAEITKLRSRVDLKLQELQHLKNEGDHLrnvQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHgRTAGAMQVEK 592

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1264 ANKHEEVLRKIETLNAItdsnRILREERNAltlRVAELTDRISSVEKELFPLQCSNKELTSKIEEINVENTSLRTEAIKW 1343
Cdd:pfam15921  593 AQLEKEINDRRLELQEF----KILKDKKDA---KIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTS 665

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1344 RQRANALVEKSNRNPEEFKRLQAEREHLAKLLtaEKELNKKQSDeltvLKQRMNTEIPMLNKQ---------MQILDEAR 1414
Cdd:pfam15921  666 RNELNSLSEDYEVLKRNFRNKSEEMETTTNKL--KMQLKSAQSE----LEQTRNTLKSMEGSDghamkvamgMQKQITAK 739

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442623382  1415 KKQVDEFTNLKQNNTRQTQDIMELKNRLlqkEEELLKANEELET----KDKTIADKETKELQLRKLAKRYKDFYIGL 1487
Cdd:pfam15921  740 RGQIDALQSKIQFLEEAMTNANKEKHFL---KEEKNKLSQELSTvateKNKMAGELEVLRSQERRLKEKVANMEVAL 813
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
 133-352 8.58e-03

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 40.90  E-value: 8.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   133 ELERLKQDLHTYQQQLSSAIAAKCEAIARVDEIQSKE-----VALELKENRMESERDMLHKEIllisgdlNKSNAELQNI 207
Cdd:pfam09787    1 NLESAKQELADYKQKAARILQSKEKLIASLKEGSGVEgldssTALTLELEELRQERDLLREEI-------QKLRGQIQQL 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   208 RREhtintmqlqsclkektesLKLMQEQYEQAVKTIGELTSKIEMQNDTAFKQNQATEEYVGKLKKELDAKEKLFEIFKS 287
Cdd:pfam09787   74 RTE------------------LQELEAQQQEEAESSREQLQELEEQLATERSARREAEAELERLQEELRYLEEELRRSKA 135

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442623382   288 TESDHLIQREELLQGI-------SEIKRLLEEAEEQCAQLTE---QMETMKQKHSAELDEQNKKIQAMEQELASA 352
Cdd:pfam09787  136 TLQSRIKDREAEIEKLrnqltskSQSSSSQSELENRLHQLTEtliQKQTMLEALSTEKNSLVLQLERMEQQIKEL 210
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 646-1118 8.90e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 41.25  E-value: 8.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   646 FEESRKlekRVRQLEQQLEGEVKKYASLKENYDYYTSEKRKNDALAQEQFDSMRKEVRELTSSNCKLMNTTEFQKEQIEL 725
Cdd:pfam05483  263 LEESRD---KANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEE 339

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   726 LHKNIGTYKQQVTTLEERTKNYEKTIIKHEQTVHLLKDEM----MAAHRKHAAAD--------------------AEAQS 781
Cdd:pfam05483  340 LNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLkiitMELQKKSSELEemtkfknnkeveleelkkilAEDEK 419

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   782 LRQENRILRDTSSRLQ------------IEKETYHREQQ------SQSLLLNSLEFIKTNLERSEMEGRQRLEQ--RLDD 841
Cdd:pfam05483  420 LLDEKKQFEKIAEELKgkeqelifllqaREKEIHDLEIQltaiktSEEHYLKEVEDLKTELEKEKLKNIELTAHcdKLLL 499

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   842 TVRELAAQRRHFQEEEEKFRESINEFKRQAETAIKLKDEEKQLADKWQAELTSVREELAEKVNKVNELSKKLQEvlTPTL 921
Cdd:pfam05483  500 ENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEE--NARS 577

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382   922 NDNPITAANKRAREFELKLDQATVEIESLTKELAKTREHGEQFYKMSqSAESEIKRLHELHgelVAKQEEEIKKLRSSEA 1001
Cdd:pfam05483  578 IEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKG-SAENKQLNAYEIK---VNKLELELASAKQKFE 653

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623382  1002 EL------KTRISDLEAEAMLSNVTEQSKTVNQSGQLKSAQDdlKSLLEKLTEANCTIRTLRSENTSLVESLNAAEVKYA 1075
Cdd:pfam05483  654 EIidnyqkEIEDKKISEEKLLEEVEKAKAIADEAVKLQKEID--KRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYK 731

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 442623382  1076 NGMIQHS----ADIQELTRYKAEFFKANDELNQLKSGRESLQAAYDE 1118
Cdd:pfam05483  732 NKEQEQSsakaALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKE 778
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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