DNA fragmentation factor-related protein 1, isoform B [Drosophila melanogaster]
Protein Classification
CIDE_N domain-containing protein( domain architecture ID 11261923)
CIDE_N domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| CAD | smart00266 | Domains present in proteins implicated in post-mortem DNA fragmentation; |
12-85 | 3.53e-35 | ||
Domains present in proteins implicated in post-mortem DNA fragmentation; : Pssm-ID: 128562 Cd Length: 74 Bit Score: 122.05 E-value: 3.53e-35
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| Name | Accession | Description | Interval | E-value | ||
| CAD | smart00266 | Domains present in proteins implicated in post-mortem DNA fragmentation; |
12-85 | 3.53e-35 | ||
Domains present in proteins implicated in post-mortem DNA fragmentation; Pssm-ID: 128562 Cd Length: 74 Bit Score: 122.05 E-value: 3.53e-35
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| CIDE_N | cd01615 | CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) ... |
11-85 | 5.45e-34 | ||
CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of ICAD/DFF45, and the CAD/DFF40 and CIDE nucleases during apoptosis. The CIDE-N domain is also found in the FSP27/CIDE-C protein. Pssm-ID: 119367 Cd Length: 78 Bit Score: 118.79 E-value: 5.45e-34
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| CIDE-N | pfam02017 | CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. ... |
12-85 | 7.87e-31 | ||
CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain. Pssm-ID: 460413 Cd Length: 75 Bit Score: 110.67 E-value: 7.87e-31
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| Name | Accession | Description | Interval | E-value | ||
| CAD | smart00266 | Domains present in proteins implicated in post-mortem DNA fragmentation; |
12-85 | 3.53e-35 | ||
Domains present in proteins implicated in post-mortem DNA fragmentation; Pssm-ID: 128562 Cd Length: 74 Bit Score: 122.05 E-value: 3.53e-35
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| CIDE_N | cd01615 | CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) ... |
11-85 | 5.45e-34 | ||
CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of ICAD/DFF45, and the CAD/DFF40 and CIDE nucleases during apoptosis. The CIDE-N domain is also found in the FSP27/CIDE-C protein. Pssm-ID: 119367 Cd Length: 78 Bit Score: 118.79 E-value: 5.45e-34
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| CIDE-N | pfam02017 | CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. ... |
12-85 | 7.87e-31 | ||
CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain. Pssm-ID: 460413 Cd Length: 75 Bit Score: 110.67 E-value: 7.87e-31
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| CIDE_N_A | cd06539 | CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, ... |
12-85 | 1.73e-14 | ||
CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40, ICAD/DFF45, and CIDE nucleases during apoptosis. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, the CIDE proteins were initially characterized as mitochondrial activators of apoptosis. However, strong metabolic phenotypes of mice lacking CIDE-A and CIDE-B indicated that this family may play critical roles in energy balance. Pssm-ID: 119372 Cd Length: 78 Bit Score: 67.28 E-value: 1.73e-14
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| CIDE_N_FSP27 | cd06538 | CIDE_N domain of FSP27 proteins. The CIDE-N (cell death-inducing DFF45-like effector, ... |
12-89 | 3.86e-13 | ||
CIDE_N domain of FSP27 proteins. The CIDE-N (cell death-inducing DFF45-like effector, N-terminal) domain is found in the FSP27/CIDE-C protein, which has been identified as a n adipocyte lipid droplet protein that negatively regulates lipolysis and promotes triglyceride accumulation. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, CIDE proteins were initially characterized as mitochondrial activators of apoptosis. The CIDE-N domain of FSP27 is sufficient to increase apoptosis in vitro when overexpressed. Pssm-ID: 119371 Cd Length: 79 Bit Score: 63.68 E-value: 3.86e-13
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| CIDE_N_ICAD | cd06536 | CIDE_N domain of ICAD. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) ... |
11-85 | 7.72e-12 | ||
CIDE_N domain of ICAD. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD (DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40 and ICAD/DFF45 during apoptosis. In normal cells, DFF exists in the nucleus as a heterodimer composed of CAD/DFF40 as a latent nuclease and its chaperone and inhibitor subunit ICAD/DFF45. Apoptotic activation of caspase-3 results in the cleavage of DFF45/ICAD and release of active DFF40/CAD nuclease. Pssm-ID: 119369 Cd Length: 80 Bit Score: 60.20 E-value: 7.72e-12
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| CIDE_N_B | cd06537 | CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, ... |
11-85 | 6.59e-09 | ||
CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40, ICAD/DFF45 and CIDE nucleases during apoptosis. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, CIDE proteins were initially characterized as mitochondrial activators of apoptosis. However, strong metabolic phenotypes of mice lacking CIDE-A and CIDE-B indicated that this family may play critical roles in energy balance. Pssm-ID: 119370 Cd Length: 81 Bit Score: 51.84 E-value: 6.59e-09
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| CIDE_N_CAD | cd06535 | CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) ... |
12-85 | 1.55e-07 | ||
CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of CAD/DFF40 and ICAD/DFF45 during apoptosis. In normal cells, DFF exists in the nucleus as a heterodimer composed of CAD/DFF40 as a latent nuclease and its chaperone and inhibitor subunit ICAD/DFF45. Apoptotic activation of caspase-3 results in the cleavage of DFF45/ICAD and the release of active DFF40/CAD nuclease. Pssm-ID: 119368 Cd Length: 77 Bit Score: 48.18 E-value: 1.55e-07
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