BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins; The family includes uncharacterized Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947 189 NVDTVCALLASAERYIQYKCTKTLVQKVLEFVDEHGTEVLNLGSFTLLPQHVVRLILAREELRADEFTKFQAALMWSKKY 268
Cdd:cd18507    1 NVDTVCALLASAERYDQYKCTKTLVQKVLEFVDKHGTDVLNLPEFLLLPEHVVRLILSRDSLGADEMTKFQAALAWSRKY 80

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins; The family includes uncharacterized Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947 189 NVDTVCALLASAERYIQYKCTKTLVQKVLEFVDEHGTEVLNLGSFTLLPQHVVRLILAREELRADEFTKFQAALMWSKKY 268
Cdd:cd18507    1 NVDTVCALLASAERYDQYKCTKTLVQKVLEFVDKHGTDVLNLPEFLLLPEHVVRLILSRDSLGADEMTKFQAALAWSRKY 80

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947   38 ELCDVTFLVGDTREPVCavKAVLASRSRVFAKMLYaapspqrkretstkenklrlflkrssepllnlqnaaqqrtgytqq 117
Cdd:pfam00651   9 ELCDVTLVVGDKEFRAH--KAVLAACSPYFKALFS--------------------------------------------- 41

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442623947  118 lapiPEPSGQQHQTLIIEEFEPDVFRQLIEYIHTGCvTLQPRTLLGVMNAADYYGLEELRRACAGFVQ 185
Cdd:pfam00651  42 ----GQESESSVSEITLDDVSPEDFEALLEFMYTGK-LISEENVDDLLAAADKLQIPSLVDKCEEFLI 104

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947   193 VCALLASAERYiqykCTKTLVQKVLEFVDEHGTEVLNLGSFTLLPQHVVRLILAREELR-ADEFTKFQAALMWSKkyYDN 271
Cdd:smart00875   1 CLGIRRFADAH----GLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNvSSEEEVFEAVLRWVK--HDP 74

                           90       100
                   ....*....|....*....|....*....
gi 442623947   272 NPNIDIKEILgtfCEYIQFHKIPANVLMR 300
Cdd:smart00875  75 EKRREHLPEL---LEHVRLPLLSPDYLLE 100

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins; The family includes uncharacterized Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947 189 NVDTVCALLASAERYIQYKCTKTLVQKVLEFVDEHGTEVLNLGSFTLLPQHVVRLILAREELRADEFTKFQAALMWSKKY 268
Cdd:cd18507    1 NVDTVCALLASAERYDQYKCTKTLVQKVLEFVDKHGTDVLNLPEFLLLPEHVVRLILSRDSLGADEMTKFQAALAWSRKY 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947  39 LCDVTFLVGDTREPVCavKAVLASRSRVFAKMLYAAPSPQRKREtstkenklrlflkrssepllnlqnaaqqrtgytqql 118
Cdd:cd18186    1 LCDVTLVVGGREFPAH--RAVLAARSPYFRAMFSSGMKESSSSE------------------------------------ 42

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 442623947 119 apipepsgqqhqtLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYY 171
Cdd:cd18186   43 -------------IELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADKL 82

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947    41 DVTFLVGDTREPVCavKAVLASRSRVFAKMLyaapspqrkrETSTKENKlrlflkrssepllnlqnaaqqrtgytqqlap 120
Cdd:smart00225   1 DVTLVVGGKKFHAH--KAVLAAHSPYFKALF----------SSDFKESD------------------------------- 37

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947   121 ipepsgqqHQTLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRAC 180
Cdd:smart00225  38 --------KSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVELC 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947  26 LAEDMKFLASMPELCDVTFLVGDTREPvcAVKAVLASRSRVFAKMLYAApspqrKRETSTKEnklrlflkrssepllnlq 105
Cdd:cd18287    9 LSEDIGALFLNEEYSDVTFVVEEKRFP--AHRVILAARSEYFRALLYGG-----MRESQQSE------------------ 63

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442623947 106 naaqqrtgytqqlAPIPEPSGQqhqtliieefepdVFRQLIEYIHTGCVTLQ---PRTLLGVMNAADYYGLEELRRA 179
Cdd:cd18287   64 -------------IELKDTNAE-------------AFKALLKYIYTGRLTLTdlkEDVLLDVLGLAHQYGFEELEAA 114

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947  25 GLAEDMKFLASMPELCDVTFLVGDTREPvCAvKAVLASRSRVFAKMLYaapSPQRKRETStkenklrlflkRSSEPLLNL 104
Cdd:cd18296    3 DLDELPFPPEQELSFPDVCFQVEGHRFP-CH-KAFFCGRSDYFKALLR---DHFAESEEN-----------NGSIPVVTL 66

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442623947 105 QNaaqqrtgytqqlapipepsgqqhqtliieeFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACA 181
Cdd:cd18296   67 HD------------------------------VSPEVFAIVLYYIYTDDTDLPPENAYDVLYVADMYLLPGLKRLCG 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 442623947 131 TLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFVQ 185
Cdd:cd18245   57 KIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947  28 EDM-KFLASmPELCDVTFLVGDTREPvcAVKAVLASRSRVFAKMLYaapspqrkretstkenklrlflkrssepllnlqn 106
Cdd:cd18292    6 QDIaQLYNN-EELSDIVLRVGGKVFH--AHRLILAKSSDVFRVMLS---------------------------------- 48

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947 107 aaqqrtgytqqlapipEPSGQQHQTLIIEEFEPD----VFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAG 182
Cdd:cd18292   49 ----------------NDWWSESKQSEIELVEDPecaaVFEKFLRYLYTGQISVNLETALPLLMLADKYNVTDLKQLCVD 112

                 ..
gi 442623947 183 FV 184
Cdd:cd18292  113 FM 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947  37 PELCDVTFLVgdtrE--PVCAVKAVLASRSRVFAKMLyaapspqrkretstkenklrlflkrSSepllnlqnaaqqrtGY 114
Cdd:cd18297   10 PEMSDVTFLV----EgrPFYAHKIVLVTASDRFKSML-------------------------SS--------------GS 46

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947 115 TQQLAPIPEpsgqqhqtliIEEFEPDVFRQLIEYIHTG---CVTLQPRTLLGVMNAADYYGLEELRRACAGFVQCCINVD 191
Cdd:cd18297   47 TEAQTPVIE----------IPDIRYDIFQLMMQYLYTGgveSLDVAQDDALELLRAASFFQLDGLKRHCEILLSQQIDLD 116

                 .
gi 442623947 192 T 192
Cdd:cd18297  117 N 117

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442623947 190 VDTVCALLASAERYIQykctKTLVQKVLEFVDEHGTEVLNLGSFTLLPQHVVRLILAREELRADEFTKFQAALMWS 265
Cdd:cd18494    2 VETACEALQAAVTYGQ----DELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELDILKAVREWA 73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947  39 LCDVTFLV--GDTREPVCAVKAVLASRSRVFAKMLYAApspqrkretsTKENKLrlflkrssepllnlqnaaqqrtgytq 116
Cdd:cd18248   21 LCDVTLKVkyQDPKEEFMAHKVVLASSSPYFKAMFTSG----------LRECGM-------------------------- 64

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442623947 117 qlapipepsgqqhQTLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGF 183
Cdd:cd18248   65 -------------EVVPIEGVHPCVMSRLIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDF 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947  26 LAEDMKFLASMPELCDVTFLVGDtrEPVCAVKAVLASRSRVFAKMLyaapspQRKRETStKENKLRlflkrssepllnlq 105
Cdd:cd18343    8 LAEDLGNLWENSRFTDCSLFVGG--QEFKAHKSILAARSPVFNAMF------EHEMEES-KKNRVE-------------- 64

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442623947 106 naaqqrtgytqqlapipepsgqqhqtliIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRAC 180
Cdd:cd18343   65 ----------------------------INDVDPEVFKEMMRFIYTGKAPNLDKMADNLLAAADKYALERLKVMC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947  39 LCDVTFLVGDtrEPVCAVKAVLASRSRVFakmlYAapspqrkretstkenklrLFLKRSSEpllnlqnaaqqrtgytqQL 118
Cdd:cd18332   19 LTDVTLLVGG--TPLRAHKAVLIACSGFF----YS------------------IFSGRVGE-----------------GV 57

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442623947 119 APIPEPSGqqhqtliieeFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFVQ 185
Cdd:cd18332   58 SVLTLPSG----------LEARGFQLLLDFMYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442623947 113 GYTQQLAPIPEPSGQQhQTLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRAC 180
Cdd:cd18218   39 GASQQLGRQLTNPNPG-QWCLGEGISPSTFKQLLDFVYGESVEVQPGELRPLLEAARALEVESLEEAC 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442623947 130 QTLI-IEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFVQC 186
Cdd:cd18238   54 QDSItIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKD 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 442623947 134 IEEFEPDVFRQLIEYIHTGCV-TLQPRTL-LGVMNAADYYGLEELRRAC 180
Cdd:cd18344   67 IHDLDPQVFKEMMGFIYTGKApHLHSHSMaCDVLAAADKYGLEGLKVLC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 442623947 134 IEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRAC 180
Cdd:cd18354   60 MSQFSYPVYRAFLEYLYTDSISLSPEDAIGLLDLATFYRENRLKKLC 106

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947  205 QYKCTKtLVQKVLEFVDEHGTEVLNLGSFTLLPQHVVRLILAREELR-ADEFTKFQAALMWSKkyYDNNPNI-DIKEILg 282
Cdd:pfam07707  10 AYGCTE-LAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNvPSEEEVFEAVIRWVK--HDVERRKkHLPELL- 85

                          90
                  ....*....|....*...
gi 442623947  283 tfcEYIQFHKIPANVLMR 300
Cdd:pfam07707  86 ---SAVRLPLLSPQYLLN 100

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442623947 222 EHGTEVLNLGSFTLLPQHVVRLILAREELRA-DEFTKFQAALMWSKkyYDNNPNIDikeILGTFCEYIQFHKIPANVL 298
Cdd:cd18509   32 ENIMEVIRNQEFLLLPAEELHKLLASDDVNVpDEETIFHALMMWVK--YDMQRRCS---DLSMLLAYIRLPLLPPQLL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442623947 134 IEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFV 184
Cdd:cd18237   65 LKDAEPDIIELLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 442623947 139 PDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFVQ 185
Cdd:cd18268   72 SDVLDQIVDYVYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQ 118

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623947  39 LCDVTFLVGDTREPVCAVKAVLASRSRVFAKMLYAAPSPQRKRETSTKENklrlflkrssEPLLNLQNAAQQRTGytqql 118
Cdd:cd18308   23 FCDVEFIVGEEEERIPAHIAFVAARSKWLRNKILQARERQKQKAEQEVED----------EGSEADSSSASKNDS----- 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442623947 119 aPIPEpsgqqhqtLIIEEFEPDVFRQLIEYIHTGCV-----TLQPRTLLGVMNAADYYGL---EELRRacagFVQCCIN 189
Cdd:cd18308   88 -PMLE--------VRLPEADPEAFELILSFIYTDKIdptrkGQDPGSNEVVLLMMDVYRLalqFQMSR----LEQLCVQ 153

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 442623947 142 FRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFVQCCINV 190
Cdd:cd18230   74 FKAIIDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDI 122