BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949  26 LAEDMKFLASMPELCDVTFLVGDTREPVCAVKAVLASRSRVFAKMLYAAPSpqrkretstkenklrlflkrssepllnlq 105
Cdd:cd18294    1 FAADMKSLINNPEFSDVKFLVGPERQEIFAHKCILAARCEVFRAMFLTGPQ----------------------------- 51

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442623949 106 naaqqpSGQQHQTLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFV 171
Cdd:cd18294   52 ------KESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949  26 LAEDMKFLASMPELCDVTFLVGDTREPVCAVKAVLASRSRVFAKMLYAAPSpqrkretstkenklrlflkrssepllnlq 105
Cdd:cd18294    1 FAADMKSLINNPEFSDVKFLVGPERQEIFAHKCILAARCEVFRAMFLTGPQ----------------------------- 51

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442623949 106 naaqqpSGQQHQTLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFV 171
Cdd:cd18294   52 ------KESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949   38 ELCDVTFLVGDTREPVCavKAVLASRSRVFAKMLYaapspqrkretstkenklrlflkrssepllnlqnaaQQPSGQQHQ 117
Cdd:pfam00651   9 ELCDVTLVVGDKEFRAH--KAVLAACSPYFKALFS------------------------------------GQESESSVS 50

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 442623949  118 TLIIEEFEPDVFRQLIEYIHTGCvTLQPRTLLGVMNAADYYGLEELRRACAGFVQ 172
Cdd:pfam00651  51 EITLDDVSPEDFEALLEFMYTGK-LISEENVDDLLAAADKLQIPSLVDKCEEFLI 104

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949   180 VCALLASAERYiqykCTKTLVQKVLEFVDEHGTEVLNLGSFTLLPQHVVRLILAREELR-ADEFTKFQAALMWSKkyYDN 258
Cdd:smart00875   1 CLGIRRFADAH----GLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNvSSEEEVFEAVLRWVK--HDP 74

                           90       100
                   ....*....|....*....|....*....
gi 442623949   259 NPNIDIKEILgtfCEYIQFHKIPANVLMR 287
Cdd:smart00875  75 EKRREHLPEL---LEHVRLPLLSPDYLLE 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949  26 LAEDMKFLASMPELCDVTFLVGDTREPVCAVKAVLASRSRVFAKMLYAAPSpqrkretstkenklrlflkrssepllnlq 105
Cdd:cd18294    1 FAADMKSLINNPEFSDVKFLVGPERQEIFAHKCILAARCEVFRAMFLTGPQ----------------------------- 51

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442623949 106 naaqqpSGQQHQTLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFV 171
Cdd:cd18294   52 ------KESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949   38 ELCDVTFLVGDTREPVCavKAVLASRSRVFAKMLYaapspqrkretstkenklrlflkrssepllnlqnaaQQPSGQQHQ 117
Cdd:pfam00651   9 ELCDVTLVVGDKEFRAH--KAVLAACSPYFKALFS------------------------------------GQESESSVS 50

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 442623949  118 TLIIEEFEPDVFRQLIEYIHTGCvTLQPRTLLGVMNAADYYGLEELRRACAGFVQ 172
Cdd:pfam00651  51 EITLDDVSPEDFEALLEFMYTGK-LISEENVDDLLAAADKLQIPSLVDKCEEFLI 104

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949    41 DVTFLVGDTREPVCavKAVLASRSRVFAKMLYaapspqrkretstkenklrlflkrssepllnlqnaaQQPSGQQHQTLI 120
Cdd:smart00225   1 DVTLVVGGKKFHAH--KAVLAAHSPYFKALFS------------------------------------SDFKESDKSEIY 42

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 442623949   121 IEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRAC 167
Cdd:smart00225  43 LDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLVELC 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949  26 LAEDMKFLASMPELCDVTFLVGDTREPvcAVKAVLASRSRVFAKMLYAApspqrKRETSTKEnklrlflkrssepllnlq 105
Cdd:cd18287    9 LSEDIGALFLNEEYSDVTFVVEEKRFP--AHRVILAARSEYFRALLYGG-----MRESQQSE------------------ 63

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442623949 106 naaqqpsgqqhqtLIIEEFEPDVFRQLIEYIHTGCVTLQ---PRTLLGVMNAADYYGLEELRRA 166
Cdd:cd18287   64 -------------IELKDTNAEAFKALLKYIYTGRLTLTdlkEDVLLDVLGLAHQYGFEELEAA 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949  41 DVTFLVG--DTREPVCAVKAVLASRSRVFAKMLYAAPSpqrkretstkENKlrlflkrssepllnlqnaaqqpsgqqhQT 118
Cdd:cd18282    9 DVHFIVGppGGTQRIPAHKYVLATGSSVFYAMFYGGLA----------ENK---------------------------NE 51

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442623949 119 LIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFVQ 172
Cdd:cd18282   52 IEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARACVQFLE 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949  38 ELCDVTFLVGDtrEPVCAVKAVLASRSRVFAKMLYAAPSpqrkrETSTKEnklrlflkrssepllnlqnaaqqpsgqqhq 117
Cdd:cd18256   19 EFCDVQLQVGM--ELFSVHRLVLAASSPYFAALFAGGMS-----ESSKDV------------------------------ 61

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 442623949 118 tLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFVQ 172
Cdd:cd18256   62 -VQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLK 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949  37 PELCDVTFLVgdtrE--PVCAVKAVLASRSRVFAKMLyaapspqrkretstkenklrlflkrsSEPLLNlqnaaqqpsgQ 114
Cdd:cd18297   10 PEMSDVTFLV----EgrPFYAHKIVLVTASDRFKSML--------------------------SSGSTE----------A 49

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442623949 115 QHQTLIIEEFEPDVFRQLIEYIHTG---CVTLQPRTLLGVMNAADYYGLEELRRACAGFVQCCINVDT 179
Cdd:cd18297   50 QTPVIEIPDIRYDIFQLMMQYLYTGgveSLDVAQDDALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949   180 VCALLASAERYiqykCTKTLVQKVLEFVDEHGTEVLNLGSFTLLPQHVVRLILAREELR-ADEFTKFQAALMWSKkyYDN 258
Cdd:smart00875   1 CLGIRRFADAH----GLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNvSSEEEVFEAVLRWVK--HDP 74

                           90       100
                   ....*....|....*....|....*....
gi 442623949   259 NPNIDIKEILgtfCEYIQFHKIPANVLMR 287
Cdd:smart00875  75 EKRREHLPEL---LEHVRLPLLSPDYLLE 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949  39 LCDVTFLV--GDTREPVCAVKAVLASRSRVFAKMLYAApspqrkretsTKENKLrlflkrssepllnlqnaaqqpsgqqh 116
Cdd:cd18248   21 LCDVTLKVkyQDPKEEFMAHKVVLASSSPYFKAMFTSG----------LRECGM-------------------------- 64

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442623949 117 QTLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGF 170
Cdd:cd18248   65 EVVPIEGVHPCVMSRLIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDF 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949  39 LCDVTFLVGDTREPvcAVKAVLASRSRVFAKMLyaapspqrkreTStkenklrlflkrssepllNLQNAAQQpsgqqhqT 118
Cdd:cd18234    1 LCDVILIAGDRRIP--AHRLVLSAVSDYFAAMF-----------TN------------------DVREATEE-------E 42

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 442623949 119 LIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGF 170
Cdd:cd18234   43 IKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLLQLSEVVEACCGF 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949  37 PELCDVTFLVGDTREPVCavKAVLASRSRVFAKMLyaapspqrkrETSTKENKLRlflkrssepllnlqnaaqqpsgqqh 116
Cdd:cd18298   10 PRTSDLKFRVDGKYIYVH--KAILKIRCEYFRSMF----------QSHWNEDDKN------------------------- 52

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442623949 117 qTLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRAC 167
Cdd:cd18298   53 -VIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGLLDLANSYCEERLKKLC 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949  26 LAEDMKFLASMPELCDVTFLVGDtREpVCAVKAVLASRSRVFAKMLyaapspqrkrETSTKENKLrlflkrssepllnlq 105
Cdd:cd18279    5 LAEDLGNLWENSRFTDCCLCVGG-QE-FQAHKAILAARSPVFSAMF----------EHEMEESKK--------------- 57

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442623949 106 naaqqpsgqqhQTLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRAC 167
Cdd:cd18279   58 -----------NRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADDLLAAADKYALERLKVMC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442623949 115 QHQTLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFV 171
Cdd:cd18273   72 KQETVTIHDVDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFL 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949  38 ELCDVTFLVGDtREPVCAvKAVLASRSRVFAKMlyaapspqrkretstkenklrlFLKRSSEpllnlqnaaqqpSGQQHQ 117
Cdd:cd18238   14 ELCDVTLKVGE-KSIHCH-RLVLACVSPYFRAM----------------------FTSEMAE------------SKQDSI 57

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442623949 118 TliIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFVQC 173
Cdd:cd18238   58 T--IKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKD 111

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949  28 EDMKFLASMPELCDVTFLVGDtREPVCAVKAVLASRSRVFAkmlyaapspqrkretstkenklRLFLkrssepllnlqna 107
Cdd:cd18299    1 EDLRNLLHSPSCADVVFILQG-GVRIFAHRIVLAAASSVFA----------------------DLFL------------- 44

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442623949 108 aqqpsgqqHQTLII--EEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACA 168
Cdd:cd18299   45 --------MMTVVTldSDITPEAFRRVLEFLYTGVLDENEDDLKELKDAAELLELFDLVMMCT 99

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949 176 NVDTVCALLASAERYiqykCTKTLVQKVLEFVDEHGTEVLNLGSFTLLPQHVVRLILAREELRADEFTKFQAALMWSkkY 255
Cdd:cd14822    2 NIRNVCLIYDVASLY----SLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRWC--E 75

                         90
                 ....*....|...
gi 442623949 256 YDNNPNIDIKEIL 268
Cdd:cd14822   76 HNPDSKEDAKEIL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 442623949 121 IEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRAC 167
Cdd:cd18218   59 GEGISPSTFKQLLDFVYGESVEVQPGELRPLLEAARALEVESLEEAC 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 442623949 121 IEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRAC 167
Cdd:cd18354   60 MSQFSYPVYRAFLEYLYTDSISLSPEDAIGLLDLATFYRENRLKKLC 106

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442623949 176 NVDTVCALLASAERYiqykCTKTLVQKVLEFVDEHGTEVLNLGSFTLLPQHVVRLILAR 234
Cdd:cd14733    1 DPENCLGILELADLY----NLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442623949  192 QYKCTKtLVQKVLEFVDEHGTEVLNLGSFTLLPQHVVRLILAREELR-ADEFTKFQAALMWSKkyYDNNPNI-DIKEILg 269
Cdd:pfam07707  10 AYGCTE-LAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNvPSEEEVFEAVIRWVK--HDVERRKkHLPELL- 85

                          90
                  ....*....|....*...
gi 442623949  270 tfcEYIQFHKIPANVLMR 287
Cdd:pfam07707  86 ---SAVRLPLLSPQYLLN 100

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442623949 209 EHGTEVLNLGSFTLLPQHVVRLILAREELRA-DEFTKFQAALMWSKkyYDNNPNIDikeILGTFCEYIQFHKIPANVL 285
Cdd:cd18509   32 ENIMEVIRNQEFLLLPAEELHKLLASDDVNVpDEETIFHALMMWVK--YDMQRRCS---DLSMLLAYIRLPLLPPQLL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 442623949 129 FRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRACAGFVQCCINV 177
Cdd:cd18230   74 FKAIIDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDI 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442623949 112 SGQQHQTLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRAC 167
Cdd:cd18217   51 TEDNIVFLDQSQVSADGFQKLLEFIYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 442623949 121 IEEFEPDVFRQLIEYIHTGCVTLQPRTLLGVMNAADYYGLEELRRAC 167
Cdd:cd18353   64 IDQFSYPVYRAFLEYLYTDSVDLPPEDAIGLLDLATSYCENRLKKLC 110