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Conserved domains on  [gi|442624571|ref|NP_001261155|]
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sulfotransferase 3, isoform C [Drosophila melanogaster]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-301 4.40e-78

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 245.72  E-value: 4.40e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624571   45 DDDVWIVTLPKCGTTWMQELLWLLLNNCDFEG---ALAKDQELRTPFLEF-GYSVFHDPNRSFGPIEDLKSPRLIKSHLS 120
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseePHLFNNHNRSPFLEWyPGDTYFDVAEGPVRLNALPSPRIIKTHLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624571  121 LALLPSKLWEGKNKVIYVSRNPLDSYVSRYYHGVSFGFNYGKSLH-QYFDEVLASDDFPTEFIEHAHEFYQLRNEPWVFY 199
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPfEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624571  200 TSFEMMKKDLRGVINDVSRFLNKPINDQQMEKLLKHLSFAEMKKNPTTNHLWELaqvqhenagKEMHPFVRRGDVNGYKD 279
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP---------KEVSPFFRKGLVGDWKN 231
                         250       260
                  ....*....|....*....|..
gi 442624571  280 ELKPEQIEKANVRIQEVLAKNG 301
Cdd:pfam00685 232 YFTPEQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-301 4.40e-78

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 245.72  E-value: 4.40e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624571   45 DDDVWIVTLPKCGTTWMQELLWLLLNNCDFEG---ALAKDQELRTPFLEF-GYSVFHDPNRSFGPIEDLKSPRLIKSHLS 120
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseePHLFNNHNRSPFLEWyPGDTYFDVAEGPVRLNALPSPRIIKTHLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624571  121 LALLPSKLWEGKNKVIYVSRNPLDSYVSRYYHGVSFGFNYGKSLH-QYFDEVLASDDFPTEFIEHAHEFYQLRNEPWVFY 199
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPfEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624571  200 TSFEMMKKDLRGVINDVSRFLNKPINDQQMEKLLKHLSFAEMKKNPTTNHLWELaqvqhenagKEMHPFVRRGDVNGYKD 279
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP---------KEVSPFFRKGLVGDWKN 231
                         250       260
                  ....*....|....*....|..
gi 442624571  280 ELKPEQIEKANVRIQEVLAKNG 301
Cdd:pfam00685 232 YFTPEQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
42-302 3.57e-08

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 55.31  E-value: 3.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624571  42 KLRDDDVWIVTLPKCGTTWMQELLWLLLNNCDFEGA----LAKDQELRTPFLEFGYSVFhdpnRSFGPIEDLKSPrLIKS 117
Cdd:PLN02164  76 QARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSsnplLKRNPHEFVPYIEIDFPFF----PSVDVLKDKGNT-LFST 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624571 118 HLSLALLPSKLWEGKNKVIYVSRNPLDSYVS--RYYHGVSFGFNYGKSLHQYFDEVLASDDFPTEFIEHAHEF---YQlR 192
Cdd:PLN02164 151 HIPYGLLPDSVVKSGCKMVYIWRDPKDTFISmwTFLHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGYwkaYQ-E 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624571 193 NEPWVFYTSFEMMKKDLRGVINDVSRFLNKPINDQQ-----MEKLLKHLSFAEMKK---NPTTNHLWELAQVQHENAgke 264
Cdd:PLN02164 230 NPDRILFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCSFETLKNleaNKGEKDREDRPAVYANSA--- 306
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 442624571 265 mhpFVRRGDVNGYKDELKPEQIEKANVRIQEVLAKNGV 302
Cdd:PLN02164 307 ---YFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-301 4.40e-78

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 245.72  E-value: 4.40e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624571   45 DDDVWIVTLPKCGTTWMQELLWLLLNNCDFEG---ALAKDQELRTPFLEF-GYSVFHDPNRSFGPIEDLKSPRLIKSHLS 120
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseePHLFNNHNRSPFLEWyPGDTYFDVAEGPVRLNALPSPRIIKTHLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624571  121 LALLPSKLWEGKNKVIYVSRNPLDSYVSRYYHGVSFGFNYGKSLH-QYFDEVLASDDFPTEFIEHAHEFYQLRNEPWVFY 199
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPfEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624571  200 TSFEMMKKDLRGVINDVSRFLNKPINDQQMEKLLKHLSFAEMKKNPTTNHLWELaqvqhenagKEMHPFVRRGDVNGYKD 279
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP---------KEVSPFFRKGLVGDWKN 231
                         250       260
                  ....*....|....*....|..
gi 442624571  280 ELKPEQIEKANVRIQEVLAKNG 301
Cdd:pfam00685 232 YFTPEQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
42-302 3.57e-08

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 55.31  E-value: 3.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624571  42 KLRDDDVWIVTLPKCGTTWMQELLWLLLNNCDFEGA----LAKDQELRTPFLEFGYSVFhdpnRSFGPIEDLKSPrLIKS 117
Cdd:PLN02164  76 QARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSsnplLKRNPHEFVPYIEIDFPFF----PSVDVLKDKGNT-LFST 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624571 118 HLSLALLPSKLWEGKNKVIYVSRNPLDSYVS--RYYHGVSFGFNYGKSLHQYFDEVLASDDFPTEFIEHAHEF---YQlR 192
Cdd:PLN02164 151 HIPYGLLPDSVVKSGCKMVYIWRDPKDTFISmwTFLHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGYwkaYQ-E 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624571 193 NEPWVFYTSFEMMKKDLRGVINDVSRFLNKPINDQQ-----MEKLLKHLSFAEMKK---NPTTNHLWELAQVQHENAgke 264
Cdd:PLN02164 230 NPDRILFLKYETMRADPLPYVKRLAEFMGYGFTAEEeekgvVEKVVKLCSFETLKNleaNKGEKDREDRPAVYANSA--- 306
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 442624571 265 mhpFVRRGDVNGYKDELKPEQIEKANVRIQEVLAKNGV 302
Cdd:PLN02164 307 ---YFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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