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Conserved domains on  [gi|442630391|ref|NP_001261445|]
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Blimp-1, isoform E [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 120-249 1.09e-66

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


:

Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 220.28  E-value: 1.09e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  120 KTLPRSLTLKSSMVystpNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYP-NDKNKARYFWRIFKD-DDYYYLDGSDRSQS 197
Cdd:cd19187     1 ASLPRNLTLKYSSV----GREVLGVWSSDYIPRGTRFGPLVGEIYTNDPvPKGANRKYFWRIYSNgEFYHYIDGFDPSKS 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 442630391  198 NWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRL 249
Cdd:cd19187    77 NWMRYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
zf-H2C2_2 pfam13465
Zinc-finger double domain;
891-916 6.20e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 6.20e-06
                           10        20
                   ....*....|....*....|....*.
gi 442630391   891 NLKVHLRTHSGERPFKCNVCTKSFTQ 916
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 925-1007 6.69e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 6.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  925 LVHTGEKPHQCDI--CKKRFSSTSNLKTHlRLHSGqkpyacdlCPQKFTQFVHLKLHKRLHTNDRPYVCQGCDKKYISAS 1002
Cdd:COG5189   342 LKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLN 412


                  ....*
gi 442630391 1003 GLRTH 1007
Cdd:COG5189   413 GLKYH 417
zf-C2HE super family cl24751
C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in ...
 858-899 3.10e-03

C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, pfam01230. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His. The fourth ligand is often mutated in neurogenerative disease-states.


The actual alignment was detected with superfamily member pfam16278:

Pssm-ID: 465082  Cd Length: 60  Bit Score: 37.27  E-value: 3.10e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 442630391   858 SRGYRSLPYPLKKKDgkmhYECNVCCKTFGQLSNLKVHLRTH 899
Cdd:pfam16278   20 KIELLPSEVLLLKTP----LKCHRCGNFGNNFPKLKAHLEEH 57
 
Name Accession Description Interval E-value
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 120-249 1.09e-66

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 220.28  E-value: 1.09e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  120 KTLPRSLTLKSSMVystpNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYP-NDKNKARYFWRIFKD-DDYYYLDGSDRSQS 197
Cdd:cd19187     1 ASLPRNLTLKYSSV----GREVLGVWSSDYIPRGTRFGPLVGEIYTNDPvPKGANRKYFWRIYSNgEFYHYIDGFDPSKS 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 442630391  198 NWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRL 249
Cdd:cd19187    77 NWMRYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 133-247 1.00e-13

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 68.90  E-value: 1.00e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391    133 VYSTPNVKtEGVWSSGVIPRGTRFGPFEG---------IPTSNYPNDKNKARYFWRIFKDddyYYLDGsdRSQSNWMRYV 203
Cdd:smart00317    5 VFKSPGKG-WGVRATEDIPKGEFIGEYVGeiitseeaeERPKAYDTDGAKAFYLFDIDSD---LCIDA--RRKGNLARFI 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 442630391    204 A-SAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFAS 247
Cdd:smart00317   79 NhSCEPNCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYAN 123
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 143-241 5.12e-08

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 52.53  E-value: 5.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391   143 GVWSSGVIPRGTRFGPFEGIP------------TSNYPNDKNKARYFWRIFKDDDYYYLDGSDRSQSNWMRYV-ASAYSL 209
Cdd:pfam00856    3 GLFATEDIPKGEFIGEYVEVLlitkeeadkrelLYYDKLELRLWGPYLFTLDEDSEYCIDARALYYGNWARFInHSCDPN 82

                           90       100       110
                   ....*....|....*....|....*....|..
gi 442630391   210 SVMNLVACQHQENIYFYTTRDILPNEELMVWY 241
Cdd:pfam00856   83 CEVRVVYVNGGPRIVIFALRDIKPGEELTIDY 114
zf-H2C2_2 pfam13465
Zinc-finger double domain;
891-916 6.20e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 6.20e-06
                           10        20
                   ....*....|....*....|....*.
gi 442630391   891 NLKVHLRTHSGERPFKCNVCTKSFTQ 916
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 925-1007 6.69e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 6.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  925 LVHTGEKPHQCDI--CKKRFSSTSNLKTHlRLHSGqkpyacdlCPQKFTQFVHLKLHKRLHTNDRPYVCQGCDKKYISAS 1002
Cdd:COG5189   342 LKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLN 412


                  ....*
gi 442630391 1003 GLRTH 1007
Cdd:COG5189   413 GLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
919-944 2.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.47e-04
                           10        20
                   ....*....|....*....|....*.
gi 442630391   919 HLQKHHLVHTGEKPHQCDICKKRFSS 944
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
150-237 6.21e-04

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 41.10  E-value: 6.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  150 IPRGTRFGPFEGIPTSN------YPNDKNKARYfwrIFKDDDYYYLDGSDRSqsNWMRYVA-SAYSlsvmNLVACQHQEN 222
Cdd:COG2940    26 IPKGTLIGEYPGEVITWaeaerrEPHKEPLHTY---LFELDDDGVIDGALGG--NPARFINhSCDP----NCEADEEDGR 96

                          90
                  ....*....|....*
gi 442630391  223 IYFYTTRDILPNEEL 237
Cdd:COG2940    97 IFIVALRDIAAGEEL 111
zf-C2HE pfam16278
C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in ...
 858-899 3.10e-03

C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, pfam01230. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His. The fourth ligand is often mutated in neurogenerative disease-states.


Pssm-ID: 465082  Cd Length: 60  Bit Score: 37.27  E-value: 3.10e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 442630391   858 SRGYRSLPYPLKKKDgkmhYECNVCCKTFGQLSNLKVHLRTH 899
Cdd:pfam16278   20 KIELLPSEVLLLKTP----LKCHRCGNFGNNFPKLKAHLEEH 57
 
Name Accession Description Interval E-value
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 120-249 1.09e-66

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 220.28  E-value: 1.09e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  120 KTLPRSLTLKSSMVystpNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYP-NDKNKARYFWRIFKD-DDYYYLDGSDRSQS 197
Cdd:cd19187     1 ASLPRNLTLKYSSV----GREVLGVWSSDYIPRGTRFGPLVGEIYTNDPvPKGANRKYFWRIYSNgEFYHYIDGFDPSKS 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 442630391  198 NWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRL 249
Cdd:cd19187    77 NWMRYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 119-250 6.45e-35

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 129.66  E-value: 6.45e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  119 DKTLPRSLTLKSSmvySTPNVKTeGVWSSGVIPRGTRFGPFEGIPTSnyPNDKNKARYFWRIFKDDD-YYYLDGSDRSQS 197
Cdd:cd19193     1 RLTLPPGLSIKRS---SIPGAGL-GVWAEAPIPKGMVFGPYEGEIVE--DEEAADSGYSWQIYKGGKlSHYIDAKDESKS 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 442630391  198 NWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRLG 250
Cdd:cd19193    75 NWMRYVNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDEYAKELG 127
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 117-250 4.67e-28

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 110.25  E-value: 4.67e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  117 RADKTLPRSLTLKSSMVysTPNVkteGVWSSGVIPRGTRFGPFEGIPTSNYP----NDKNkARYFWRIFKDDDY-YYLDG 191
Cdd:cd19189     1 RARLSLPRQLYLRQSET--GAEV---GVWTKETIPVRTCFGPLIGQQSHSAEvadwTDKA-APHIWKIYHNDVLeFCIIT 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 442630391  192 SDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRLG 250
Cdd:cd19189    75 TDENECNWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQLG 133
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 117-250 5.66e-26

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 103.97  E-value: 5.66e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  117 RADKTLPRSLTLKSSMVYSTpnvkteGVWSSGVIPRGTRFGPFEGIPTSNYPNDKNKARYFWRIFKDDDYYYLDGSDRSQ 196
Cdd:cd19194     1 RARASLPLILQIFRFGETLG------GVFAKRRIPKRTQFGPLEGPLVKKSELKDNKIHPLELEEDDGEDLYFDLSDENK 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 442630391  197 SNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRLG 250
Cdd:cd19194    75 CNWMMFVRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKVWYAASYAEFLG 128
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 122-241 2.32e-25

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 100.73  E-value: 2.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  122 LPRSLTLKSSMVYSTPnvktEGVWSSGVIPRGTRFGPFEGiptsnypndknkaryfwrifkdddyyyldgsdrsQSNWMR 201
Cdd:cd10534     1 LPAGLELVLSSIPEGG----LGVFARRTIPAGTRFGPLEG----------------------------------VVNWMR 42

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 442630391  202 YVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWY 241
Cdd:cd10534    43 FVRPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWY 82
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 119-241 8.98e-24

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 97.51  E-value: 8.98e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  119 DKTLPRSLTLKSSMVYSTPNvkteGVWSSGVIPRGTRFGPFEGiptsnypnDKNKAR------YFWRI-FKDDDYYYLDG 191
Cdd:cd19188     1 LMGLPEELELKPSAVDKTRI----GVWAKKSIPKGRKFGPFVG--------EKKKRSqvknnvYMWEIyGPKRGWMCVDA 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 442630391  192 SDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWY 241
Cdd:cd19188    69 SDPTKGNWLRYVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWY 118
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 149-249 4.25e-23

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 95.69  E-value: 4.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  149 VIPRGTRFGPFEGIPTSNypnDKNKARYFWRIF-KDDDYYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYT 227
Cdd:cd19195    27 VIPKGHIFGPYEGQICTQ---DKSSGFFSWLIVdKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSEQIYFRA 103

                          90       100
                  ....*....|....*....|..
gi 442630391  228 TRDILPNEELMVWYCKDFASRL 249
Cdd:cd19195   104 CRDIRPGEKLRVWYSEDYMKRL 125
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 143-241 7.09e-23

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 95.54  E-value: 7.09e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  143 GVWSSGVIPRGTRFGPFEG--IPTSNYP-NDKNKarYFWRIFKDDDY-YYLDGSDrSQSNWMRYVASAYSLSVMNLVACQ 218
Cdd:cd19198    21 GVFCKKTIPKGTRFGPFRGrvVNTSEIKtYDDNS--FMWEIFEDGKLsHFIDGRG-STGNWMSYVNCARYAEEQNLIAIQ 97

                          90       100
                  ....*....|....*....|...
gi 442630391  219 HQENIYFYTTRDILPNEELMVWY 241
Cdd:cd19198    98 CQGQIFYESCKEILQGQELLVWY 120
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 122-247 4.19e-21

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 90.23  E-value: 4.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  122 LPRSLTLKSSmvySTPNVKTeGVWSSGVIPRGTRFGPFEGIPTSNYPNDKN--KARYFWRIFKDDDY--YYLDGSDRSQS 197
Cdd:cd19191     1 LPDEVCLCTS---SIPGLGY-GICAAQRIPQGTWIGPFEGVLVSPEKQIGAvrNTQHLWEIYDQEGTlqHFIDGGDPSKS 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 442630391  198 NWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFAS 247
Cdd:cd19191    77 SWMRYIRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWYDDSYTS 126
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 143-244 1.73e-20

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 88.58  E-value: 1.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  143 GVWSSGVIPRGTRFGPFEGIPTSNYPNdknkARYFWRIFkDDDY---YYLDGSDRSQSNWMRYVASAYSLSVMNLVACQH 219
Cdd:cd19200    27 GVWTKVRIEVGEKFGPFVGVQRSSVKD----PTYAWEIV-DEFGkvkFWIDASEPGTGNWMKYIRSAPSCEQQNLMACQI 101

                          90       100
                  ....*....|....*....|....*
gi 442630391  220 QENIYFYTTRDILPNEELMVwYCKD 244
Cdd:cd19200   102 DEQIYYKVVRDIQPGEELLL-YMKA 125
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 117-249 6.36e-20

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 86.70  E-value: 6.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  117 RADKTLPRSLTLKssmvysTPNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYpnDKNKARYFWRIFKDDDYYYLDGSDRSQ 196
Cdd:cd19199     2 RARSSLPDNLEIR------QLEDGSEGVFALVPLVKRTQFGPFEAKRVARL--DGFAVFPLKVFEKDGSVVYLDTSNEDD 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 442630391  197 SNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRL 249
Cdd:cd19199    74 CNWMMFVRPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWYAAFYAKKM 126
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 122-250 7.94e-20

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 86.64  E-value: 7.94e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  122 LPRSLTLKSSmvySTPNVKTeGVWSSGVIPRGTRFGPFEG---IPTSNYPNDKNKarYFWRIFKDDD--YYYLDGSDRSQ 196
Cdd:cd19196     1 LPSQVIIAQS---SIPGAGL-GVFSKTWIKEGTEMGPYTGrivSPEDVDPCKNNN--LMWEVFNEDGtvSHFIDASQENH 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 442630391  197 SNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRLG 250
Cdd:cd19196    75 RSWMTFVNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWYGNSYNTFLG 128
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 122-245 2.08e-15

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 73.53  E-value: 2.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  122 LPRSLTLKSSmvySTPNVKTEGVWSSGVIPRGTRFGPFEGIPTSNyPNDKNKARYFWRIFKDDDYYYLDGSDRSqSNWMR 201
Cdd:cd19201     3 LPGELELRKP---SQDAGRSGGVWAKQPLPEGTRFGPYPGKLVKE-PLDPSYEWKVEAQGSKGGEGLLLLTEDS-GTWLK 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 442630391  202 YVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDF 245
Cdd:cd19201    78 LVRSADDEDEANLILYFKGGQIWCEVTKDIPPGEELILVLREPL 121
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 133-247 1.00e-13

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 68.90  E-value: 1.00e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391    133 VYSTPNVKtEGVWSSGVIPRGTRFGPFEG---------IPTSNYPNDKNKARYFWRIFKDddyYYLDGsdRSQSNWMRYV 203
Cdd:smart00317    5 VFKSPGKG-WGVRATEDIPKGEFIGEYVGeiitseeaeERPKAYDTDGAKAFYLFDIDSD---LCIDA--RRKGNLARFI 78

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 442630391    204 A-SAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFAS 247
Cdd:smart00317   79 NhSCEPNCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYAN 123
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 122-241 1.10e-13

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 68.86  E-value: 1.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  122 LPRSLTLKSSMVYSTpnvktEGVWSSGVIPRGTRFGPFEGipTSNYPNDKNKA---RYFWRI--FKDDDYYYLDGSDRSQ 196
Cdd:cd19190     5 VPDRFSLKSSKVQDG-----MGLYTARRVKKGEKFGPFAG--EKRMPNELDESmdpRLMWEVrgSKGEVLYILDASNPRH 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 442630391  197 SNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWY 241
Cdd:cd19190    78 SNWLRFVHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGY 122
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 123-249 1.07e-12

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 66.30  E-value: 1.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  123 PRSLTLKSSMVYSTPnvKTEGVWSSGVIPRGTRFGPFEGIPTSNY--------PNDKNKARYFWRIFKDDDyyyldGSDR 194
Cdd:cd19192     3 HRSLWRGGSKSVLTD--IFTSVVTTTDIPAGTIFGPCVLSFTLGYdiadialkTTDKRVVPYIFRVDTGAC-----NGSS 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 442630391  195 SQSNWMRYVASAYSLSVMNLVA-CQHQENIYFYTTRDILPNEELMVWYCKDFASRL 249
Cdd:cd19192    76 EPSDWLRLVQPARDRHEQNLEAfRKNEGQVYFRTLRRIRKGEELLVWYSDELAELL 131
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 119-244 2.80e-11

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 62.97  E-value: 2.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  119 DKTLPRSLTLKSSmvySTPNVKTeGVWSSGVIPRGTRFGPFEGIPTSNYP----------NDKNKARYFWRIFKDDDY-- 186
Cdd:cd19213    17 DIPIPSDFELRES---SIPGAGL-GVWAKRKIEAGERFGPYTGVQRSTLKdtnfgweqilNDVEVSSQEGCITKIVDDlg 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442630391  187 ---YYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVwYCKD 244
Cdd:cd19213    93 nekFCVDAGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLV-YVKD 152
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 143-240 4.42e-10

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 59.57  E-value: 4.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  143 GVWSSGVIPRGTRFGPFEGIPTSNYPNdknkARYFWRIFkdDDYYY----LDGSDRSQSNWMRYVASAYSLSVMNLVACQ 218
Cdd:cd19214    47 GIWTKRKIEVGEKFGPYVGEQRSNLKD----PSYGWEVL--DEFGNvkfcIDASQPDVGSWLKYIRFAGCYDQHNLVACQ 120

                          90       100
                  ....*....|....*....|..
gi 442630391  219 HQENIYFYTTRDILPNEELMVW 240
Cdd:cd19214   121 INDQIFYRAVADIDPGEELLLF 142
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 150-247 7.01e-10

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 57.52  E-value: 7.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  150 IPRGTRFGPFEGIPTSNypNDKNKARYFWRIFKDDDY---YYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQEN--IY 224
Cdd:cd19197     1 IPAGLRLGPVPGIFKLG--KYLSDRKEPGNKKKVRRVrgdYLVDESGSPATEWIGLVRAARNNQEQNLEAIADLPGgqIF 78

                          90       100
                  ....*....|....*....|...
gi 442630391  225 FYTTRDILPNEELMVWYCKDFAS 247
Cdd:cd19197    79 YRALRDIQPGEELTVWYSNSLAQ 101
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 143-241 5.12e-08

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 52.53  E-value: 5.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391   143 GVWSSGVIPRGTRFGPFEGIP------------TSNYPNDKNKARYFWRIFKDDDYYYLDGSDRSQSNWMRYV-ASAYSL 209
Cdd:pfam00856    3 GLFATEDIPKGEFIGEYVEVLlitkeeadkrelLYYDKLELRLWGPYLFTLDEDSEYCIDARALYYGNWARFInHSCDPN 82

                           90       100       110
                   ....*....|....*....|....*....|..
gi 442630391   210 SVMNLVACQHQENIYFYTTRDILPNEELMVWY 241
Cdd:pfam00856   83 CEVRVVYVNGGPRIVIFALRDIKPGEELTIDY 114
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 118-240 3.63e-07

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 50.11  E-value: 3.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  118 ADKTLPRSLTLKSSMVYStpnvKTEGVWSSG-VIPRGTRFGPFEGIPTS----NYPNDKNKARYFW---RIFKDddyyyl 189
Cdd:cd10520     1 ALRSLPPGLALGPSLAQE----ERLGVWCVGdALQKGTFLGPLEEELEShdltEGGSPRQEESGQSgdvLACEQ------ 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 442630391  190 dgsdrsQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVW 240
Cdd:cd10520    71 ------SSKWMRFACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLW 115
zf-H2C2_2 pfam13465
Zinc-finger double domain;
891-916 6.20e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 6.20e-06
                           10        20
                   ....*....|....*....|....*.
gi 442630391   891 NLKVHLRTHSGERPFKCNVCTKSFTQ 916
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 925-1007 6.69e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 6.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  925 LVHTGEKPHQCDI--CKKRFSSTSNLKTHlRLHSGqkpyacdlCPQKFTQFVHLKLHKRLHTNDRPYVCQGCDKKYISAS 1002
Cdd:COG5189   342 LKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLN 412


                  ....*
gi 442630391 1003 GLRTH 1007
Cdd:COG5189   413 GLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
919-944 2.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.47e-04
                           10        20
                   ....*....|....*....|....*.
gi 442630391   919 HLQKHHLVHTGEKPHQCDICKKRFSS 944
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
947-972 3.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 3.70e-04
                           10        20
                   ....*....|....*....|....*.
gi 442630391   947 NLKTHLRLHSGQKPYACDLCPQKFTQ 972
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
903-986 4.42e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 4.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  903 RPFKCNVCTKSFTQLAHLQKHHLVHTGEKPHQC--DICKKRFSSTSNLKTHLRLHSGQKPYAC--DLCPQKFTQFVHLKL 978
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLS 111


                  ....*...
gi 442630391  979 HKRLHTND 986
Cdd:COG5048   112 SSSSNSND 119
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
150-237 6.21e-04

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 41.10  E-value: 6.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  150 IPRGTRFGPFEGIPTSN------YPNDKNKARYfwrIFKDDDYYYLDGSDRSqsNWMRYVA-SAYSlsvmNLVACQHQEN 222
Cdd:COG2940    26 IPKGTLIGEYPGEVITWaeaerrEPHKEPLHTY---LFELDDDGVIDGALGG--NPARFINhSCDP----NCEADEEDGR 96

                          90
                  ....*....|....*
gi 442630391  223 IYFYTTRDILPNEEL 237
Cdd:COG2940    97 IFIVALRDIAAGEEL 111
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 933-955 7.54e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 7.54e-04
                           10        20
                   ....*....|....*....|...
gi 442630391   933 HQCDICKKRFSSTSNLKTHLRLH 955
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 143-245 1.17e-03

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 40.02  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  143 GVWSSGVIPRGTRFGPFEGIPTSNYPNDknkARYFWRIFK------DDDYYYLDGSdrSQSNWMRYVASA--YSLSVMnl 214
Cdd:cd10522    16 GLFAAETIAKGEFVGEYTGEVLDRWEED---RDSVYHYDPlypfdlNGDILVIDAG--KKGNLTRFINHSdqPNLELI-- 88

                          90       100       110
                  ....*....|....*....|....*....|..
gi 442630391  215 VACQHQEN-IYFYTTRDILPNEELMVWYCKDF 245
Cdd:cd10522    89 VRTLKGEQhIGFVAIRDIKPGEELFISYGPKY 120
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 905-927 1.53e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.53e-03
                           10        20
                   ....*....|....*....|...
gi 442630391   905 FKCNVCTKSFTQLAHLQKHHLVH 927
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2HE pfam16278
C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in ...
 858-899 3.10e-03

C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, pfam01230. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His. The fourth ligand is often mutated in neurogenerative disease-states.


Pssm-ID: 465082  Cd Length: 60  Bit Score: 37.27  E-value: 3.10e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 442630391   858 SRGYRSLPYPLKKKDgkmhYECNVCCKTFGQLSNLKVHLRTH 899
Cdd:pfam16278   20 KIELLPSEVLLLKTP----LKCHRCGNFGNNFPKLKAHLEEH 57
zf-H2C2_2 pfam13465
Zinc-finger double domain;
975-1000 4.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 4.61e-03
                           10        20
                   ....*....|....*....|....*.
gi 442630391   975 HLKLHKRLHTNDRPYVCQGCDKKYIS 1000
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SSL1 COG5151
RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit ...
 904-997 8.03e-03

RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227480 [Multi-domain]  Cd Length: 421  Bit Score: 39.98  E-value: 8.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630391  904 PFKCNVCTKSFTQLAHLQK--HHL--------VHTGEKPH--QCDICKKRFSSTSNLKTHLRLHSGQkpYACDLCPQKFT 971
Cdd:COG5151   322 PISCPICSLQLILSTHLARsyHHLyplkpfveKPEGTNPKstHCFVCQGPFPKPPVSPFDESTSSGR--YQCELCKSTFC 399

                          90       100
                  ....*....|....*....|....*.
gi 442630391  972 QFVHLKLHKRLHTndrpyvCQGCDKK 997
Cdd:COG5151   400 SDCDVFIHETLHF------CIGCELP 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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