|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
368-634 |
1.37e-31 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 125.84 E-value: 1.37e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 368 TDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIM 447
Cdd:COG0666 17 LLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAAR 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 448 NGgrltdfaeqvancqTQAQLKLLL------NEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAAR 521
Cdd:COG0666 97 NG--------------DLEIVKLLLeagadvNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 522 YGRYNTVRQLLdsEKGsFIINESDGAGMTPLHISSQQGHTRVVQLLLNRGA-LLHRDHTGRNPLQLAAMSGYTETIELLH 600
Cdd:COG0666 163 NGNLEIVKLLL--EAG-ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAdVNAKDNDGKTALDLAAENGNLEIVKLLL 239
|
250 260 270
....*....|....*....|....*....|....
gi 442631141 601 SvHSHLLDQVDKDGNTALHLATMENKPHAISVLM 634
Cdd:COG0666 240 E-AGADLNAKDKDGLTALLLAAAAGAALIVKLLL 272
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
293-599 |
2.08e-30 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 122.37 E-value: 2.08e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 293 MISFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMFEMQPMEKRlclscTDVQK 372
Cdd:COG0666 13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA-----KDDGG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 373 MTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGAcisvkdaaarNVlhfvimnggrl 452
Cdd:COG0666 88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGA----------DV----------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 453 tdfaeqvancqtqaqlklllNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLL 532
Cdd:COG0666 147 --------------------NAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLL 206
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631141 533 dsEKGSfIINESDGAGMTPLHISSQQGHTRVVQLLLNRGALL-HRDHTGRNPLQLAAMSGYTETIELL 599
Cdd:COG0666 207 --EAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLnAKDKDGLTALLLAAAAGAALIVKLL 271
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
298-516 |
9.87e-28 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 114.67 E-value: 9.87e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 298 DSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMfemqpMEKRLCLSCTDVQKMTPLH 377
Cdd:COG0666 84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL-----LEAGADVNAQDNDGNTPLH 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 378 CASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRltdfae 457
Cdd:COG0666 159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNL------ 232
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 442631141 458 qvANCQTQAQLKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPL 516
Cdd:COG0666 233 --EIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
466-673 |
1.11e-27 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 114.28 E-value: 1.11e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 466 AQLKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLdsEKGsFIINESD 545
Cdd:COG0666 41 LLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLL--EAG-ADVNARD 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 546 GAGMTPLHISSQQGHTRVVQLLLNRGALLH-RDHTGRNPLQLAAMSGYTETIELL--HSVHshlLDQVDKDGNTALHLAT 622
Cdd:COG0666 118 KDGETPLHLAAYNGNLEIVKLLLEAGADVNaQDNDGNTPLHLAAANGNLEIVKLLleAGAD---VNARDNDGETPLHLAA 194
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 442631141 623 MENKPHAISVLMSMGCKL-VYNVLDMSAIDYAIYYKYPEAALAMVTHEERAN 673
Cdd:COG0666 195 ENGHLEIVKLLLEAGADVnAKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
140-461 |
2.14e-26 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 110.81 E-value: 2.14e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 140 ILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLATELNKVKSLRVMGQYRNVIDI 219
Cdd:COG0666 1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 220 QQGGEHGRTALHLAAIYDHEECARILITefdacprkpcnngyypiHEAAKNASsktmevffqwgeqrgctreemisfyDS 299
Cdd:COG0666 81 NAKDDGGNTLLHAAARNGDLEIVKLLLE-----------------AGADVNAR-------------------------DK 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 300 EGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMfemqpMEKRLCLSCTDVQKMTPLHCA 379
Cdd:COG0666 119 DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL-----LEAGADVNARDNDGETPLHLA 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 380 SMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRLTDFAEQV 459
Cdd:COG0666 194 AENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
|
..
gi 442631141 460 AN 461
Cdd:COG0666 274 AL 275
|
|
| Ion_trans |
pfam00520 |
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ... |
849-1073 |
2.38e-24 |
|
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 103.12 E-value: 2.38e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 849 LDSCEERINRTTAILFCAVVIVVYILLNSMreLIQIYQQ--KLHYILETVNLISWVLYISALVMVTPAfqpdggiNTIHY 926
Cdd:pfam00520 21 LETYFQPEEPLTTVLEILDYVFTGIFTLEM--LLKIIAAgfKKRYFRSPWNILDFVVVLPSLISLVLS-------SVGSL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 927 SAASIAVFLSWFRLLLFLQRFDQVGIYVVMFLEILQTLIKVLMVFSILIIAFGLAFYILLSKI----IDPQPNHLSFSNI 1002
Cdd:pfam00520 92 SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlktwENPDNGRTNFDNF 171
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631141 1003 PMSLLRTFSMMLGElDFVGTYVNTYYRdqlKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQ 1073
Cdd:pfam00520 172 PNAFLWLFQTMTTE-GWGDIMYDTIDG---KGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
481-1092 |
3.19e-24 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 109.33 E-value: 3.19e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 481 SPLHYASRDGHIRSLENLIRLGACINL-KNNNNESPLHFAARYGRYNTVRQLLDSEKGsfIINE---SD-GAGMTPLHIS 555
Cdd:cd22192 19 SPLLLAAKENDVQAIKKLLKCPSCDLFqRGALGETALHVAALYDNLEAAVVLMEAAPE--LVNEpmtSDlYQGETALHIA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 556 SQQGHTRVVQLLLNRGA------------LLHRD---HTGRNPLQLAAMSGYTETIELLHSVHSHLLDQvDKDGNTALH- 619
Cdd:cd22192 97 VVNQNLNLVRELIARGAdvvspratgtffRPGPKnliYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQ-DSLGNTVLHi 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 620 LATMENKPHAisvlmsmgcKLVYNVLdmsaidyaiyykypeaaLAMVTHEERANEVMALRSDKHPCVTLALIASMPKVFE 699
Cdd:cd22192 176 LVLQPNKTFA---------CQMYDLI-----------------LSYDKEDDLQPLDLVPNNQGLTPFKLAAKEGNIVMFQ 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 700 -AVQDKCITKANCKKDSKSFYIKY---SFWPYQKTPEQIEAKRKEFndpkwrpaPLAVVNTmvthgrvellaHPLSQkYL 775
Cdd:cd22192 230 hLVQKRRHIQWTYGPLTSTLYDLTeidSWGDEQSVLELIVSSKKRE--------ARKILDV-----------TPVKE-LV 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 776 QMKWNSYGKYFHLANLLIYsifLVFVTIYSSLMMNNIELKAGDNKTMSQyCNMGWEQLTMNLS-QNPSvaSQIRLDSceE 854
Cdd:cd22192 290 SLKWKRYGRPYFRILALLY---LLYIIIFTLCCVYRPLKPRPENNTDPR-DITLYVQKTLQESyVTPK--DYLRLVG--E 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 855 RINrttaiLFCAVVIVVYILLNSMRELIQIY--QQKL----HYILETVnliswvlyiSALVMVTPAFQ---PDGGINTIh 925
Cdd:cd22192 362 LIS-----VLGAIVILLLEIPDILRVGVKRYfgQTVLggpfHVIIITY---------ACLVLLTLVLRltsLSGEVVPM- 426
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 926 ysaaSIAVFLSWFRLLLFLQRFDQVGIYVVMFLEIL-QTLIKVLMVFSILIIAFGLAFYILLsKIIDPQPNhLSFSNIPM 1004
Cdd:cd22192 427 ----SLALVLGWCNVMYFARGFQMLGPFTIMIQKIIfGDLMKFCWLMFVVILGFSSAFYMIF-QTEDPDSL-GHFYDFPM 500
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 1005 SLLRTFSMMLGELDFVGTYvntyyrDQLKVPMTSFLIlSVFMILMPILLMNLLIGLaVGDieSVRRNAQ----LKRlaMQ 1080
Cdd:cd22192 501 TLFSTFELFLGLIDGPANY------TVDLPFMYKVLY-TAFAVIAYLLMLNLLIAM-MGD--THWRVAHerdeLWR--AQ 568
|
650
....*....|...
gi 442631141 1081 VVLHT-ELERKLP 1092
Cdd:cd22192 569 VVATTlMLERRLP 581
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
73-404 |
2.04e-21 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 96.18 E-value: 2.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 73 LEAILPAEPPAEVCLLRDSPFRILRAAESGNLDDFKRLFMADNSRIALKDAKGRTAAHQAAARNRVNILRYIRDQNGDFN 152
Cdd:COG0666 35 LLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 153 AKDNAGNTPLHIAVESDAYDALDYLLsipvdtgvlneKKQApvhlatelnkvkslrvmgqyrnviDIQQGGEHGRTALHL 232
Cdd:COG0666 115 ARDKDGETPLHLAAYNGNLEIVKLLL-----------EAGA------------------------DVNAQDNDGNTPLHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 233 AAIYDHEECARILItefdacprkpcNNGyypiheAAKNASsktmevffqwgeqrgctreemisfyDSEGNVPLHSAVHGG 312
Cdd:COG0666 160 AAANGNLEIVKLLL-----------EAG------ADVNAR-------------------------DNDGETPLHLAAENG 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 313 DIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMfemqpMEKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLV 392
Cdd:COG0666 198 HLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLL-----LEAGADLNAKDKDGLTALLLAAAAGAALIVKLLL 272
|
330
....*....|..
gi 442631141 393 AEGADINALDKE 404
Cdd:COG0666 273 LALLLLAAALLD 284
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
289-587 |
1.07e-20 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 96.57 E-value: 1.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 289 TREEMISFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLmfemqpmekrLCLSCT 368
Cdd:PHA02874 23 NKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKL----------LIDNGV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 369 DVQkMTPLHCAsmfdHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAarnvlhfvimn 448
Cdd:PHA02874 93 DTS-ILPIPCI----EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDN----------- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 449 ggrltdfaeqvancqtqaqlklllnekdsmGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTV 528
Cdd:PHA02874 157 ------------------------------GCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACI 206
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 529 RQLLDSekGSFIINESDGaGMTPLHISSQqgHTR-VVQLLLNRGALLHRDHTGRNPLQLA 587
Cdd:PHA02874 207 KLLIDH--GNHIMNKCKN-GFTPLHNAII--HNRsAIELLINNASINDQDIDGSTPLHHA 261
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
473-1060 |
2.36e-19 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 93.99 E-value: 2.36e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 473 NEKDSMGCSPLHYASRDGHIRSLENLirlgacinLKNNNN-----ESPLHfAARYGRYNTVRQLL------DSEKGS-FI 540
Cdd:TIGR00870 46 NCPDRLGRSALFVAAIENENLELTEL--------LLNLSCrgavgDTLLH-AISLEYVDAVEAILlhllaaFRKSGPlEL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 541 INESDG----AGMTPLHISSQQGHTRVVQLLLNRGALLH----------RDHT-----GRNPLQLAAMSGYTETIELLhS 601
Cdd:TIGR00870 117 ANDQYTseftPGITALHLAAHRQNYEIVKLLLERGASVParacgdffvkSQGVdsfyhGESPLNAAACLGSPSIVALL-S 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 602 VHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMGCKlvynvldmsaiDYAIYYkypeaaLAMvTHEERANEVMALRSD 681
Cdd:TIGR00870 196 EDPADILTADSLGNTLLHLLVMENEFKAEYEELSCQMY-----------NFALSL------LDK-LRDSKELEVILNHQG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 682 KHPcVTLALIASMPKVFEavqdkciTKANCKKDSKsfyiKYSFWPYqkTPEQIEAKRKEfNDPKWRPAPLAV-------V 754
Cdd:TIGR00870 258 LTP-LKLAAKEGRIVLFR-------LKLAIKYKQK----KFVAWPN--GQQLLSLYWLE-ELDGWRRKQSVLelivvfvI 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 755 NTMVTHGRVELLAHPLSqKYLQMKWNSYGK-YFHlANLLIYSIFLVFVTIysslmmnnielKAGDNKTMSQYCNMGWEQL 833
Cdd:TIGR00870 323 GLKFPELSDMYLIAPLS-RLGQFKWKPFIKfIFH-SASYLYFLYLIIFTS-----------VAYYRPTRTDLRVTGLQQT 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 834 TMNLSQNPSVASqIRLDSCEErinrttaILFCAVVIVVYILLNSMReliqiyQQKLHYILETVNL--ISWVLYISALVMV 911
Cdd:TIGR00870 390 PLEMLIVTWVDG-LRLGEEKL-------IWLGGIFEYIHQLWNILD------FGMNSFYLATFLDrpFAILFVTQAFLVL 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 912 TPAFQPdgGINTIHYSAA-SIAVFLSWFRLLLFLQRFDQVGIYVVMFLE-ILQTLIKVLMVFSILIIAFGLAFYILLS-- 987
Cdd:TIGR00870 456 REHWLR--FDPTLIEEALfAFALVLSWLNLLYIFRGNQHLGPLQIMIGRmILGDILRFLFIYAVVLFGFACGLNQLYQyy 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 988 ------------KIIDPQPNHlSFSNIPMSLLRTF--SMMLGELDFvgtyvntyyRDQLKVPMTSFLILSVFMILMPILL 1053
Cdd:TIGR00870 534 delklnecsnphARSCEKQGN-AYSTLFETSQELFwaIIGLGDLLA---------NEHKFTEFVGLLLFGAYNVIMYILL 603
|
....*..
gi 442631141 1054 MNLLIGL 1060
Cdd:TIGR00870 604 LNMLIAM 610
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
513-1092 |
5.09e-19 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 92.64 E-value: 5.09e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 513 ESPLHFAARY---GRYNTVRQLLDSEKGSFIINESDGA--------GMTPLHISSQQGHTRVVQLLLNRGALLHRDHTGR 581
Cdd:cd21882 27 KTCLHKAALNlndGVNEAIMLLLEAAPDSGNPKELVNApctdefyqGQTALHIAIENRNLNLVRLLVENGADVSARATGR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 582 --------------NPLQLAAMSGYTETIELL--HSVHSHLLDQVDKDGNTALHLATM--ENKPHAISVLMSMgcklvYN 643
Cdd:cd21882 107 ffrkspgnlfyfgeLPLSLAACTNQEEIVRLLleNGAQPAALEAQDSLGNTVLHALVLqaDNTPENSAFVCQM-----YN 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 644 VLdmsaidyaiyYKYPEAALAMVTHEERANevmalrsdkHPCVT-LALIASMPK--VFEAVQDKCITKAnCKKDSKSFyI 720
Cdd:cd21882 182 LL----------LSYGAHLDPTQQLEEIPN---------HQGLTpLKLAAVEGKivMFQHILQREFSGP-YQPLSRKF-T 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 721 KYSFWPYQKTP---EQIEAKRKEfndpkwrpaplAVVNTMVTHGRVE-----LLAHPLsQKYLQMKWNSYGK---YFHLA 789
Cdd:cd21882 241 EWTYGPVTSSLydlSEIDSWEKN-----------SVLELIAFSKKREarhqmLVQEPL-NELLQEKWDRYGRpyfCFNFA 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 790 NLLIYSIFLVFVTIYSSLmmnnielkagdnktmsqycnmgwEQLTMNLSQNPSVASQIRLdsceerinrTTAILfcAVVI 869
Cdd:cd21882 309 CYLLYMIIFTVCAYYRPL-----------------------KDRPANQEAKATFGDSIRL---------VGEIL--TVLG 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 870 VVYILLnsmRELIQIYQQKLHYILETVNLISWVLYI--SALVMVTPAFQPdggINTIHYSAA-SIAVFLSWFRLLLFLQR 946
Cdd:cd21882 355 GVYILL---GEIPYFFRRRLSRWFGFLDSYFEILFItqALLVLLSMVLRF---METEGYVVPlVFSLVLGWCNVLYYTRG 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 947 FDQVGIYVVMFLE-ILQTLIKVLMVFSILIIAFGLAFYILLSkiiDPQPNHL-SFSNIPMSLLRTFSMMLGELDFVGTYv 1024
Cdd:cd21882 429 FQMLGIYTVMIQKmILRDLMRFCWVYLVFLFGFASAFVILFQ---TEDPNKLgEFRDYPDALLELFKFTIGMGDLPFNE- 504
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442631141 1025 ntyyrdQLKVPMTSFLILSVFMILMPILLMNLLIGLAVgdiESVRRNAQ----LKRLamQVVLHT-ELERKLP 1092
Cdd:cd21882 505 ------NVDFPFVYLILLLAYVILTYLLLLNMLIALMG---ETVNRVAQesdeIWKL--QKAITTlMLERKYP 566
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
95-336 |
3.47e-18 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 86.55 E-value: 3.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 95 ILRAAESGNLDDFKRLfMADNSRIALKDAKGRTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDAL 174
Cdd:COG0666 91 LHAAARNGDLEIVKLL-LEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 175 DYLLSIPVDtgvlnekkqapvhlatelnkvkslrvmgqyrnvIDIQqgGEHGRTALHLAAIYDHEECARILItEFDACPR 254
Cdd:COG0666 170 KLLLEAGAD---------------------------------VNAR--DNDGETPLHLAAENGHLEIVKLLL-EAGADVN 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 255 KPCNNGYYPIHEAAKNASSKTMEVFFQWGEQrgctreemISFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDL 334
Cdd:COG0666 214 AKDNDGKTALDLAAENGNLEIVKLLLEAGAD--------LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
|
..
gi 442631141 335 ST 336
Cdd:COG0666 286 LT 287
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
294-570 |
4.58e-17 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 85.85 E-value: 4.58e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 294 ISFYDSEGNVPLHSAVHGG---DIKAVELCLKSGAKISTQQHDLSTPVHL-ACAQGAIDIVKLMFEMQpmekrlclscTD 369
Cdd:PHA03095 40 VNFRGEYGKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHLyLYNATTLDVIKLLIKAG----------AD 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 370 VQK-----MTPLH--CASMFDHPDIVSYLVAEGADINALDKEHRSPL--LLAASRSGWKTVHLLIRLGACISVKDAAARN 440
Cdd:PHA03095 110 VNAkdkvgRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLIDAGADVYAVDDRFRS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 441 VLHFvimnggrltdFAEqvaNCQTQAQ-LKLLL------NEKDSMGCSPLHYASRDGHIRS--LENLIRLGACINLKNNN 511
Cdd:PHA03095 190 LLHH----------HLQ---SFKPRARiVRELIragcdpAATDMLGNTPLHSMATGSSCKRslVLPLLIAGISINARNRY 256
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 442631141 512 NESPLHFAARYGRYNTVRQLLdseKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNR 570
Cdd:PHA03095 257 GQTPLHYAAVFNNPRACRRLI---ALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAK 312
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
482-662 |
4.62e-17 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 83.08 E-value: 4.62e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 482 PLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLdseKGSFIINESDGAGMTPLHISSQQGHT 561
Cdd:COG0666 24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLL---AAGADINAKDDGGNTLLHAAARNGDL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 562 RVVQLLLNRGA-LLHRDHTGRNPLQLAAMSGYTETIELLhsvhshL-----LDQVDKDGNTALHLATMENKPHAISVLMS 635
Cdd:COG0666 101 EIVKLLLEAGAdVNARDKDGETPLHLAAYNGNLEIVKLL------LeagadVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174
|
170 180
....*....|....*....|....*...
gi 442631141 636 MGCKL-VYNVLDMSAIDYAIYYKYPEAA 662
Cdd:COG0666 175 AGADVnARDNDGETPLHLAAENGHLEIV 202
|
|
| TRPV3 |
cd22194 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ... |
503-1107 |
6.81e-17 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411978 [Multi-domain] Cd Length: 680 Bit Score: 85.97 E-value: 6.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 503 ACINLKNNNNEsplhfaarygrynTVRQLLDSEKGSFI----IN----ESDGAGMTPLHISSQQGHTRVVQLLLNRGALL 574
Cdd:cd22194 101 ALLNINENTKE-------------IVRILLAFAEENGIldrfINaeytEEAYEGQTALNIAIERRQGDIVKLLIAKGADV 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 575 HRDHTGR---------------NPLQLAAMSGYTETIELLHSVHSHLLDQVDKDGNTALHlatmenkphaisvlmsmgcK 639
Cdd:cd22194 168 NAHAKGVffnpkykhegfyfgeTPLALAACTNQPEIVQLLMEKESTDITSQDSRGNTVLH-------------------A 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 640 LVYNVLDMSAIDYAIYYKYPEAALAmvtHEERANEVMalrSDKHPCVTLALIASMPK--VFEAVQDKCITKanckKDSKS 717
Cdd:cd22194 229 LVTVAEDSKTQNDFVKRMYDMILLK---SENKNLETI---RNNEGLTPLQLAAKMGKaeILKYILSREIKE----KPNRS 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 718 FYIKYSFWPYqkTPEQIEAKRKEFNDPKWRPAPL--AVVNTMVTHgRVELLA-HPLsQKYLQMKWNSYGKYFHLANLLIY 794
Cdd:cd22194 299 LSRKFTDWAY--GPVSSSLYDLTNVDTTTDNSVLeiIVYNTNIDN-RHEMLTlEPL-HTLLHMKWKKFARYMFFISFLFY 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 795 SIFLVFVTIYSSLmmnnielKAGDNKTMSQYCN----MGWEQLTmnlsqnpsvaSQIrldsceerinrttAILFCAVviv 870
Cdd:cd22194 375 FFYNITLTLVSYY-------RPREDEDPPHPLAlshkMGWLQLL----------GQM-------------FVLIWAT--- 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 871 vYILLNSMRELIQIYQQKLHYILEtvnlISW---VLYISALVMVTPAFQPDGGInTIHYSAASIAVFLSWFRLLLFLQRF 947
Cdd:cd22194 422 -CLSVKEGIAIFLLRPSDLKSILS----DAWfhiLFFIQAVLVIVSVFLYLFAY-KEYLACLVLAMALGWANMLYYTRGF 495
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 948 DQVGIYVVMFLE-ILQTLIKVLMVFSILIIAFGLAFYILLSKIIDPQPNHlSFSNIPMSLLRTFSMMLGELDFVGTYVNT 1026
Cdd:cd22194 496 QSLGIYSVMIQKvILNDVLKFLLVYILFLLGFGVALASLIEDCPDDSECS-SYGSFSDAVLELFKLTIGLGDLEIQQNSK 574
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 1027 YyrdqlkvPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQ----LKRlAMQVVlhtELERKLPhVWLQRvdKM 1102
Cdd:cd22194 575 Y-------PILFLLLLITYVILTFVLLLNMLIALMGETVENVSKESEriwrLQR-ARTIL---EFEKSLP-EWLRK--RF 640
|
....*
gi 442631141 1103 ELIEY 1107
Cdd:cd22194 641 RLGEL 645
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
483-572 |
8.45e-17 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 76.69 E-value: 8.45e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 483 LHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDsekgsFIINESDGAGMTPLHISSQQGHTR 562
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-----HADVNLKDNGRTALHYAARSGHLE 75
|
90
....*....|
gi 442631141 563 VVQLLLNRGA 572
Cdd:pfam12796 76 IVKLLLEKGA 85
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
303-534 |
1.24e-16 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 83.95 E-value: 1.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 303 VPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAI-----DIVKLMfemqpMEKRLCLSCTDVQKMTPLH 377
Cdd:PHA03100 37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLL-----LEYGANVNAPDNNGITPLL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 378 CASM--FDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKT--VHLLIRLGACISVKdaaarNVLHFVIMNGgrlt 453
Cdd:PHA03100 112 YAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLLIDKGVDINAK-----NRVNYLLSYG---- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 454 dfaeqvancqtqaqlkLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLD 533
Cdd:PHA03100 183 ----------------VPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
|
.
gi 442631141 534 S 534
Cdd:PHA03100 247 N 247
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
305-402 |
4.86e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 71.69 E-value: 4.86e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 305 LHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMFEMQPMEKRLclsctdvQKMTPLHCASMFDH 384
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD-------NGRTALHYAARSGH 73
|
90
....*....|....*...
gi 442631141 385 PDIVSYLVAEGADINALD 402
Cdd:pfam12796 74 LEIVKLLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
516-599 |
6.90e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 71.30 E-value: 6.90e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 516 LHFAARYGRYNTVRQLLDSEKGsfiINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLHRDHtGRNPLQLAAMSGYTET 595
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGAD---ANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN-GRTALHYAARSGHLEI 76
|
....
gi 442631141 596 IELL 599
Cdd:pfam12796 77 VKLL 80
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
314-572 |
9.94e-15 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 77.78 E-value: 9.94e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 314 IKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMFEmqpmeKRLCLSCTDVQKMTPLHCASMFDH-----PDIV 388
Cdd:PHA03100 15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLD-----NGADINSSTKNNSTPLHYLSNIKYnltdvKEIV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 389 SYLVAEGADINALDKEHRSPLLLAASRS--GWKTVHLLIRLGACISVKDAAARNVLHFVIMNggrltdfaeqvaNCQTQA 466
Cdd:PHA03100 90 KLLLEYGANVNAPDNNGITPLLYAISKKsnSYSIVEYLLDNGANVNIKNSDGENLLHLYLES------------NKIDLK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 467 QLKLLL------NEKDSmgcsplhyasrdghirsLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDseKGSFI 540
Cdd:PHA03100 158 ILKLLIdkgvdiNAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLD--LGANP 218
|
250 260 270
....*....|....*....|....*....|..
gi 442631141 541 iNESDGAGMTPLHISSQQGHTRVVQLLLNRGA 572
Cdd:PHA03100 219 -NLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
374-638 |
6.53e-13 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 72.75 E-value: 6.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 374 TPLH-CASMFDHP--DIVSYLVAEGADINALDKEHRSPL-LLAASRSGWKTVHLLIRLGACISVKDAAARNVLHfvimng 449
Cdd:PHA03095 49 TPLHlYLHYSSEKvkDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLH------ 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 450 grltdfaeqvancqtqaqlklllnekdsmgcspLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYN--T 527
Cdd:PHA03095 123 ---------------------------------VYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANveL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 528 VRQLLDseKGSFIINeSDGAGMTPLHISSQQGHTR--VVQLLLNRGA-LLHRDHTGRNPLQLAAMSGYTETIELLHSVHS 604
Cdd:PHA03095 170 LRLLID--AGADVYA-VDDRFRSLLHHHLQSFKPRarIVRELIRAGCdPAATDMLGNTPLHSMATGSSCKRSLVLPLLIA 246
|
250 260 270
....*....|....*....|....*....|....*
gi 442631141 605 HL-LDQVDKDGNTALHLATMENKPHAISVLMSMGC 638
Cdd:PHA03095 247 GIsINARNRYGQTPLHYAAVFNNPRACRRLIALGA 281
|
|
| TRPV1 |
cd22196 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ... |
501-1060 |
4.93e-12 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411980 [Multi-domain] Cd Length: 649 Bit Score: 70.22 E-value: 4.93e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 501 LGACINLKNNNNESPLHFAARYGRYNTVRQLLDSEkgsfiINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLH----- 575
Cdd:cd22196 52 LKAMLNLHNGQNDTISLLLDIAEKTGNLKEFVNAA-----YTDSYYKGQTALHIAIERRNMHLVELLVQNGADVHarasg 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 576 ---RDHTGRN-------PLQLAAMSGYTETIE-LLHSVHSHL-LDQVDKDGNTALH--LATMENKPHAISVLMSMgcklv 641
Cdd:cd22196 127 effKKKKGGPgfyfgelPLSLAACTNQLDIVKfLLENPHSPAdISARDSMGNTVLHalVEVADNTPENTKFVTKM----- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 642 YNVLDMSAIDYaiyykYPEAALamvthEERANevmalrsdKHPCVTLALIASMPK--VFEAVQDKCITKANCKKDSKsfy 719
Cdd:cd22196 202 YNEILILGAKI-----RPLLKL-----EEITN--------KKGLTPLKLAAKTGKigIFAYILGREIKEPECRHLSR--- 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 720 iKYSFWPYQKTPEQIEAKRKEFNDPKWRPAPLAVVNTMVTHGRVELLAHPLSqKYLQMKWNSYGKYFHLANLLIYSIFLV 799
Cdd:cd22196 261 -KFTEWAYGPVHSSLYDLSSIDTYEKNSVLEIIAYSSETPNRHEMLLVEPLN-KLLQDKWDKFVKRIFYFNFFVYFIYMI 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 800 FVTIysslmmnnielkAGDNKTmsqycnmgwEQLTMNLSQNPSVASQIRLDSceERINRTTAILFCAVVIVVYILLNSMR 879
Cdd:cd22196 339 IFTL------------AAYYRP---------VNKTPPFPIENTTGEYLRLTG--EIISVSGGVYFFFRGIQYFLQRRPSL 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 880 E--LIQIYQQKLHYILETVNLISWVLYISAlvmvtpafqpdggiNTIHYSAASIAVFLSWFRLLLFLQRFDQVGIYVVMF 957
Cdd:cd22196 396 KklIVDSYCEILFFVQSLFLLASTVLYFCG--------------RNEYVAFMVISLALGWANVLYYTRGFQQMGIYSVMI 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 958 LE-ILQTLIKVLMVFSILIIAFGLAFYILL------------SKIIDPQPNHLSFSNIPMSLLR--TFSMMLGELDFVgt 1022
Cdd:cd22196 462 QKmILRDICRFLFVYLVFLFGFSAALVTLIedgppkgdvntsQKECVCKSGYNSYNSLYSTCLElfKFTIGMGDLEFT-- 539
|
570 580 590
....*....|....*....|....*....|....*...
gi 442631141 1023 yvntyyrDQLKVPMTSFLILSVFMILMPILLMNLLIGL 1060
Cdd:cd22196 540 -------ENYKFKEVFIFLLISYVILTYILLLNMLIAL 570
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
479-694 |
1.13e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 68.48 E-value: 1.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 479 GCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDSekGSFIINESDGAGMTPLHISSQQ 558
Cdd:PHA02875 35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDL--GKFADDVFYKDGMTPLHLATIL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 559 GHTRVVQLLLNRGALLHRDHTGR-NPLQLAAMSGYTETIELLHSvHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMG 637
Cdd:PHA02875 113 KKLDIMKLLIARGADPDIPNTDKfSPLHLAVMMGDIKGIELLID-HKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSG 191
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 442631141 638 CKLVY--NVLDMSAIDYAIYYKYPEAALAMVTHEERANEVMALRSDKhpCVTLALIASM 694
Cdd:PHA02875 192 ANIDYfgKNGCVAALCYAIENNKIDIVRLFIKRGADCNIMFMIEGEE--CTILDMICNM 248
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
95-183 |
1.69e-11 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 61.67 E-value: 1.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 95 ILRAAESGNLDDFKRLFMAdNSRIALKDAKGRTAAHQAAARNRVNILRYIRDqNGDFNAKDNaGNTPLHIAVESDAYDAL 174
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLEN-GADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIV 77
|
....*....
gi 442631141 175 DYLLSIPVD 183
Cdd:pfam12796 78 KLLLEKGAD 86
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
162-246 |
1.78e-11 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 61.67 E-value: 1.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 162 LHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLATELNKVKSLRVMGQYRNVidiqQGGEHGRTALHLAAIYDHEEC 241
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV----NLKDNGRTALHYAARSGHLEI 76
|
....*
gi 442631141 242 ARILI 246
Cdd:pfam12796 77 VKLLL 81
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
387-599 |
1.95e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 67.77 E-value: 1.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 387 IVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRLTDFAEQVancqtqa 466
Cdd:PHA03100 17 NIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDVKEIV------- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 467 qlKLLL------NEKDSMGCSPLHYAS--RDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNT--VRQLLDseK 536
Cdd:PHA03100 90 --KLLLeyganvNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLLID--K 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631141 537 GSFI---------------INESDGAGMTPLHISSQQGHTRVVQLLLNRGALLH-RDHTGRNPLQLAAMSGYTETIELL 599
Cdd:PHA03100 166 GVDInaknrvnyllsygvpINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNlVNKYGDTPLHIAILNNNKEIFKLL 244
|
|
| TRPV1-4 |
cd22193 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ... |
501-1102 |
2.18e-11 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411977 [Multi-domain] Cd Length: 607 Bit Score: 68.28 E-value: 2.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 501 LGACINLKNNNNEsplhfaarygrynTVRQLLDSEKGSFIINESDGA--------GMTPLHISSQQGHTRVVQLLLNRGA 572
Cdd:cd22193 34 MKALLNLNPGTND-------------TIRILLDIAEKTDNLKRFINAeytdeyyeGQTALHIAIERRQGDIVALLVENGA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 573 LLHRDHTGR---------------NPLQLAAMSGYTETIE-LLHSVHSHL-LDQVDKDGNTALH--LATMENKPHaisvl 633
Cdd:cd22193 101 DVHAHAKGRffqpkyqgegfyfgeLPLSLAACTNQPDIVQyLLENEHQPAdIEAQDSRGNTVLHalVTVADNTKE----- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 634 msmGCKLVYNVLDMSAIDYAIYYkyPEAALamvtheeranEVMALRSDKHPcvtLALIASMPK--VFEAVQDKCITKANC 711
Cdd:cd22193 176 ---NTKFVTRMYDMILIRGAKLC--PTVEL----------EEIRNNDGLTP---LQLAAKMGKieILKYILQREIKEPEL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 712 KKDSKsfyiKYSFWPYqkTPEQIEAKRKEFNDPKWRPAPLAVV--NTMVTHGRVELLAHPLSqKYLQMKWNSYGK---YF 786
Cdd:cd22193 238 RHLSR----KFTDWAY--GPVSSSLYDLSNVDTCEKNSVLEIIvyNSKIDNRHEMLTLEPLN-TLLQDKWDKFAKymfFF 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 787 HLANLLIYSIFLVFVTIYSSLMMNNIELKAGDNKtmsqycnMGWEQLTmnlsqnpsvasqirldscEERINRTTAILFCA 866
Cdd:cd22193 311 SFCFYLFYMIIFTLVAYYRPREDEPPPPLAKTTK-------MDYMRLL------------------GEILVLLGGVYFFV 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 867 VVIVVYIL--LNSMRELIQIYQQKLHYILETVNLISWVLYISAlvmvtpafqpdgginTIHYSAASI-AVFLSWFRLLLF 943
Cdd:cd22193 366 KEIAYFLLrrSDLQSSFSDSYFEILFFVQAVLVILSVVLYLFA---------------YKEYLACLVlALALGWANMLYY 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 944 LQRFDQVGIYVVMFLE-ILQTLIKVLMVFSILIIAFGLAFYILLSKIIDPQPNHLSFSNIPMSLLRTFSMM--LGELDFV 1020
Cdd:cd22193 431 TRGFQSMGIYSVMIQKvILRDLLRFLFVYLLFLFGFAVALVSLIEKCSSDKKDCSSYGSFSDAVLELFKLTigMGDLEFQ 510
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 1021 gtyvntyyrDQLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNA-QLKRLAMQVVLhTELERKLPhVWLQRV 1099
Cdd:cd22193 511 ---------ENSTYPAVFLILLLTYVILTFVLLLNMLIALMGETVNNVSKESkRIWKLQRAITI-LEFEKSFP-ECMRKA 579
|
...
gi 442631141 1100 DKM 1102
Cdd:cd22193 580 FRS 582
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
84-522 |
3.17e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 67.78 E-value: 3.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 84 EVCLlrdspfRILRAAESGNLDDFKRLfmaDNSRIALKDAKGRTAahqaaaRNRVNILRYIRDQNGDFNAKDNAGNTPLH 163
Cdd:PHA02876 119 EACI------HILKEAISGNDIHYDKI---NESIEYMKLIKERIQ------QDELLIAEMLLEGGADVNAKDIYCITPIH 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 164 IAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLATELNKVKSLRvmgqyrnvidiqqggehgrtalhlaAIYDHeecar 243
Cdd:PHA02876 184 YAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIK-------------------------AIIDN----- 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 244 ilitefdacpRKPCNNGYYPIHEAAKNASSKTMEVFFQWGEQrgctreemISFYDSEGNVPLHSAVHGGDI-KAVELCLK 322
Cdd:PHA02876 234 ----------RSNINKNDLSLLKAIRNEDLETSLLLYDAGFS--------VNSIDDCKNTPLHHASQAPSLsRLVPKLLE 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 323 SGAKISTQQHDLSTPVHLACAQGaidivklmFEMQPMEKRLCL----SCTDVQKMTPLHCASMFD-HPDIVSYLVAEGAD 397
Cdd:PHA02876 296 RGADVNAKNIKGETPLYLMAKNG--------YDTENIRTLIMLgadvNAADRLYITPLHQASTLDrNKDIVITLLELGAN 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 398 INALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRLTdfaeqvaNCQTQAQLKLLLNEKDS 477
Cdd:PHA02876 368 VNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYM-------SVKTLIDRGANVNSKNK 440
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 442631141 478 MGCSPLHYASRDG-HIRSLENLIRLGACINLKNNNNESPLHFAARY 522
Cdd:PHA02876 441 DLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALEY 486
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
468-660 |
4.07e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 66.61 E-value: 4.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 468 LKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYgRYN------TVRQLLdsEKGSfII 541
Cdd:PHA03100 24 EDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNI-KYNltdvkeIVKLLL--EYGA-NV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 542 NESDGAGMTPLH--ISSQQGHTRVVQLLLNRGALLH-RDHTGRNPLQLAAMSGYTET------------------IELLH 600
Cdd:PHA03100 100 NAPDNNGITPLLyaISKKSNSYSIVEYLLDNGANVNiKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLL 179
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631141 601 SVHSHLlDQVDKDGNTALHLATMENKPHAISVLMSMGCKL-VYNVLDMSAIDYAIYYKYPE 660
Cdd:PHA03100 180 SYGVPI-NIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPnLVNKYGDTPLHIAILNNNKE 239
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
379-583 |
4.10e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 66.55 E-value: 4.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 379 ASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGgrltdfaeQ 458
Cdd:PHA02875 9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEG--------D 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 459 VANCQTQAQLKLLLNE---KDSMgcSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDSE 535
Cdd:PHA02875 81 VKAVEELLDLGKFADDvfyKDGM--TPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHK 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 442631141 536 KgsfIINESDGAGMTPLHISSQQGHTRVVQLLLNRGAllHRDHTGRNP 583
Cdd:PHA02875 159 A---CLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA--NIDYFGKNG 201
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
130-446 |
1.01e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 65.67 E-value: 1.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 130 HQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNE-KKQAPVHLATELNKVKSLr 208
Cdd:PHA02878 42 HQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTlVAIKDAFNNRNVEIFKII- 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 209 VMGQYRNV--IDIQQGGEHGRTALHLAAIydheecARILITEFDACPRKPCNNGYYPIHEAAKNASSKTMEVFFQWGEQr 286
Cdd:PHA02878 121 LTNRYKNIqtIDLVYIDKKSKDDIIEAEI------TKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGAN- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 287 gctreemISFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQ-GAIDIVKLMfemqpMEKRLCL 365
Cdd:PHA02878 194 -------VNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLL-----LEHGVDV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 366 SC-TDVQKMTPLHCAsmFDHPDIVSYLVAEGADINALDKEHRSPLLLAA-SRSGWKTVHLLIRLGACISVKDAAARNVLH 443
Cdd:PHA02878 262 NAkSYILGLTALHSS--IKSERKLKLLLEYGADINSLNSYKLTPLSSAVkQYLCINIGRILISNICLLKRIKPDIKNSEG 339
|
...
gi 442631141 444 FVI 446
Cdd:PHA02878 340 FID 342
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
161-412 |
2.47e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 64.21 E-value: 2.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 161 PLHIAVESDAYDALDYLLSIPVDTGVLnekkqaPVhlaTELNK--VKSLRVMGqyrnvIDIQQGGEHGRTALHLAAIYDH 238
Cdd:PHA02874 71 PLLTAIKIGAHDIIKLLIDNGVDTSIL------PI---PCIEKdmIKTILDCG-----IDVNIKDAELKTFLHYAIKKGD 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 239 EECARILItEFDACPRKPCNNGYYPIHEAAKNASSKTMEVFFQWGeqrgctreEMISFYDSEGNVPLHSAVHGGDIKAVE 318
Cdd:PHA02874 137 LESIKMLF-EYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKG--------AYANVKDNNGESPLHNAAEYGDYACIK 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 319 LCLKSGAKISTQQHDLSTPVHLACAQGAiDIVKLMFEMQpmekrlCLSCTDVQKMTPLHCAsmFDHP---DIVSYLVAEG 395
Cdd:PHA02874 208 LLIDHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLINNA------SINDQDIDGSTPLHHA--INPPcdiDIIDILLYHK 278
|
250
....*....|....*..
gi 442631141 396 ADINALDKEHRSPLLLA 412
Cdd:PHA02874 279 ADISIKDNKGENPIDTA 295
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
303-532 |
2.87e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 64.13 E-value: 2.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 303 VPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQG------------------------------------- 345
Cdd:PHA02878 39 IPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPnklgmkemirsinkcsvfytlvaikdafnnrnveifk 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 346 -----------AIDIVKL-----MFEMQPMEKRLCLS-CTDVQKM------TPLHCASMFDHPDIVSYLVAEGADINALD 402
Cdd:PHA02878 119 iiltnrykniqTIDLVYIdkkskDDIIEAEITKLLLSyGADINMKdrhkgnTALHYATENKDQRLTELLLSYGANVNIPD 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 403 KEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFvimnggrltdfaeQVANCQTQAQLKLLL------NEKD 476
Cdd:PHA02878 199 KTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHI-------------SVGYCKDYDILKLLLehgvdvNAKS 265
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 442631141 477 S-MGCSPLHYASRDGhiRSLENLIRLGACINLKNNNNESPLHFAAR-YGRYNTVRQLL 532
Cdd:PHA02878 266 YiLGLTALHSSIKSE--RKLKLLLEYGADINSLNSYKLTPLSSAVKqYLCINIGRILI 321
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
336-653 |
3.33e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 64.31 E-value: 3.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 336 TPVHLACAQGAIDIVKLMFEMQPMekrlCLSCTDVQKMTPLHCASMFdhPDIVSYLVAEGADINALDKEHRSPLLLAASR 415
Cdd:PHA02876 43 TAIHQALQLRQIDIVEEIIQQNPE----LIYITDHKCHSTLHTICII--PNVMDIVISLTLDCDIILDIKYASIILNKHK 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 416 SGWKTVHLLirlgacisvKDAAARNVLHFVIMNggRLTDFAEQVANCQTQAQLKLL---------LNEKDSMGCSPLHYA 486
Cdd:PHA02876 117 LDEACIHIL---------KEAISGNDIHYDKIN--ESIEYMKLIKERIQQDELLIAemlleggadVNAKDIYCITPIHYA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 487 SRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDSEK--------------------------GSFI 540
Cdd:PHA02876 186 AERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSninkndlsllkairnedletslllydAGFS 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 541 INESDGAGMTPLHISSQQGH-TRVVQLLLNRGALLH-RDHTGRNPLQLAAMSGY-TETIELLHSVHSHlLDQVDKDGNTA 617
Cdd:PHA02876 266 VNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNaKNIKGETPLYLMAKNGYdTENIRTLIMLGAD-VNAADRLYITP 344
|
330 340 350
....*....|....*....|....*....|....*...
gi 442631141 618 LHLA-TMENKPHAISVLMSMGCKL-VYNVLDMSAIDYA 653
Cdd:PHA02876 345 LHQAsTLDRNKDIVITLLELGANVnARDYCDKTPIHYA 382
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
117-341 |
4.21e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 63.44 E-value: 4.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 117 RIALKDAKGRTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLsipvdtgvlnEKkqapvh 196
Cdd:PHA02874 116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLL----------EK------ 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 197 latelnkvkslrvmGQYRNVIDiqqggEHGRTALHLAAIYDHEECARILITEFDACPRKpCNNGYYPIHEAAKNASSkTM 276
Cdd:PHA02874 180 --------------GAYANVKD-----NNGESPLHNAAEYGDYACIKLLIDHGNHIMNK-CKNGFTPLHNAIIHNRS-AI 238
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631141 277 EVFFQwgeqrgctrEEMISFYDSEGNVPLHSAVH-GGDIKAVELCLKSGAKISTQQHDLSTPVHLA 341
Cdd:PHA02874 239 ELLIN---------NASINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
339-435 |
6.62e-10 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 57.05 E-value: 6.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 339 HLACAQGAIDIVKLMFEmQPMEKRlclsCTDVQKMTPLHCASMFDHPDIVSYLVaEGADINALDkEHRSPLLLAASRSGW 418
Cdd:pfam12796 2 HLAAKNGNLELVKLLLE-NGADAN----LQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKD-NGRTALHYAARSGHL 74
|
90
....*....|....*..
gi 442631141 419 KTVHLLIRLGACISVKD 435
Cdd:pfam12796 75 EIVKLLLEKGADINVKD 91
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
133-412 |
1.64e-09 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 61.58 E-value: 1.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 133 AARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLSIpVDTGV-LNEK---KQAPVHL----ATELNKV 204
Cdd:PHA03095 22 ASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIVRLL-LEAGAdVNAPercGFTPLHLylynATTLDVI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 205 KSLRVMGqyrnvIDIQQGGEHGRTALH--LAAIYDHEECARILItEFDACPRKPCNNGYYPIHEAAK--NASSKTMEVFF 280
Cdd:PHA03095 101 KLLIKAG-----ADVNAKDKVGRTPLHvyLSGFNINPKVIRLLL-RKGADVNALDLYGMTPLAVLLKsrNANVELLRLLI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 281 QWGEQrgctreemISFYDSEGNVPLHSavHGGDIKA----VELCLKSGAKISTQQHDLSTPVHLACAQG---AIDIVKLM 353
Cdd:PHA03095 175 DAGAD--------VYAVDDRFRSLLHH--HLQSFKPrariVRELIRAGCDPAATDMLGNTPLHSMATGSsckRSLVLPLL 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 442631141 354 femqpmEKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLA 412
Cdd:PHA03095 245 ------IAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLM 297
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
376-509 |
1.12e-08 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 53.58 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 376 LHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRlgacisvkdaaarnvlhfvimnggrltdf 455
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE----------------------------- 51
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 442631141 456 aeqvancqtqaqlKLLLNEKDSmGCSPLHYASRDGHIRSLENLIRLGACINLKN 509
Cdd:pfam12796 52 -------------HADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
|
|
| PKD_channel |
pfam08016 |
Polycystin cation channel; This family contains the cation channel region from group II of ... |
857-1060 |
1.79e-08 |
|
Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.
Pssm-ID: 462341 [Multi-domain] Cd Length: 225 Bit Score: 56.52 E-value: 1.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 857 NRTTAILFCAVVIVVYILLNSMRELIQIYQQKLHYILETVNLISWVLYI-SALVMV------------------TP-AFQ 916
Cdd:pfam08016 5 NRSLFILLCEIVFVVFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVIlSVVLIVlniyrdfladrliksveaSPvTFI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 917 PDGGINTIHYSA---ASIAVFLSWFRLLLFLQRFDQvgiyVVMFLEILQTLIKVLM----VFSILIIAFGLAFYILLSKi 989
Cdd:pfam08016 85 DFDRVAQLDNLYriiLAFLVFLTWLKLFKVLRFNKT----MSLFTKTLSRAWKDLAgfalMFVIFFFAYAQFGYLLFGT- 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631141 990 idpqpNHLSFSNIPMSLLRTFSMMLGelDFVGTYVNTYYRdqlkvpMTSFLILSVFMILMPILLMNLLIGL 1060
Cdd:pfam08016 160 -----QAPNFSNFVKSILTLFRTILG--DFGYNEIFSGNR------VLGPLLFLTFVFLVIFILLNLFLAI 217
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
304-659 |
1.87e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 58.92 E-value: 1.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 304 PLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMFEMQPMEKRLCLSCTDVQKMTPLHCASMfd 383
Cdd:PHA02876 181 PIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDLSLLKAIRNEDLETSLL-- 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 384 hpdivsyLVAEGADINALDKEHRSPLLLAA-SRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGgrltdfaEQVANC 462
Cdd:PHA02876 259 -------LYDAGFSVNSIDDCKNTPLHHASqAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNG-------YDTENI 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 463 QTQAQLKLLLNEKDSMGCSPLHYASR-DGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDSekgsfii 541
Cdd:PHA02876 325 RTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDY------- 397
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 542 nesdGAGMTPLhisSQQghtrvvqlllnRGALLHRDHTGRNPlqlaamsgYTETIELLHSVHShlLDQVDKDGNTALHLA 621
Cdd:PHA02876 398 ----GADIEAL---SQK-----------IGTALHFALCGTNP--------YMSVKTLIDRGAN--VNSKNKDLSTPLHYA 449
|
330 340 350
....*....|....*....|....*....|....*....
gi 442631141 622 TMEN-KPHAISVLMSMGCklvynvlDMSAIDyaIYYKYP 659
Cdd:PHA02876 450 CKKNcKLDVIEMLLDNGA-------DVNAIN--IQNQYP 479
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
194-384 |
4.32e-08 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 57.33 E-value: 4.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 194 PVHLATELNKVKSLRVMGQYrNVIDIQQGGEHGRTALHLAAIYDHEECARILItefDACPR---KPCNNGYY----PIHE 266
Cdd:cd22192 20 PLLLAAKENDVQAIKKLLKC-PSCDLFQRGALGETALHVAALYDNLEAAVVLM---EAAPElvnEPMTSDLYqgetALHI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 267 AAKNASSKTMEVFFQWGEQRGCTREEMISFYDSEGNV------PLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHL 340
Cdd:cd22192 96 AVVNQNLNLVRELIARGADVVSPRATGTFFRPGPKNLiyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHI 175
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 442631141 341 ACAQGAIDIVKLMFEM-QPMEKRLCLSCTDVQK----MTPLHCAS------MFDH 384
Cdd:cd22192 176 LVLQPNKTFACQMYDLiLSYDKEDDLQPLDLVPnnqgLTPFKLAAkegnivMFQH 230
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
492-668 |
6.38e-08 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 55.73 E-value: 6.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 492 IRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDsekGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRG 571
Cdd:COG0666 1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLL---ALLALALADALGALLLLAAALAGDLLVALLLLAAG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 572 ALLH-RDHTGRNPLQLAAMSGYTETIELLHSvHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMGCKLvyNVLD---M 647
Cdd:COG0666 78 ADINaKDDGGNTLLHAAARNGDLEIVKLLLE-AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADV--NAQDndgN 154
|
170 180
....*....|....*....|.
gi 442631141 648 SAIDYAIYYKYPEAALAMVTH 668
Cdd:COG0666 155 TPLHLAAANGNLEIVKLLLEA 175
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
514-568 |
6.53e-08 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 49.97 E-value: 6.53e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 442631141 514 SPLHFAARYGRYNTVRQLLDSekgSFIINESDGAGMTPLHISSQQGHTRVVQLLL 568
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEK---GADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
239-431 |
8.76e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 56.15 E-value: 8.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 239 EECARILITEFDACpRKPCNNGYYPIHEAAKNASSKTMEVFFQwgeqrgctREEMISFYDSEGNVP----------LHSA 308
Cdd:PHA02875 5 ALCDAILFGELDIA-RRLLDIGINPNFEIYDGISPIKLAMKFR--------DSEAIKLLMKHGAIPdvkypdieseLHDA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 309 VHGGDIKAVELCLKSGAKISTQQH-DLSTPVHLACAQGAIDIVKLMFEMQPMEKrlcLSCTDvqKMTPLHCASMFDHPDI 387
Cdd:PHA02875 76 VEEGDVKAVEELLDLGKFADDVFYkDGMTPLHLATILKKLDIMKLLIARGADPD---IPNTD--KFSPLHLAVMMGDIKG 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 442631141 388 VSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACI 431
Cdd:PHA02875 151 IELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANI 194
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
135-436 |
1.05e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 55.83 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 135 RNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLL--SIPVDTGVLNEKKqaPVHLATELNKVKslrvmgq 212
Cdd:PHA03100 12 IIKVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLdnGADINSSTKNNST--PLHYLSNIKYNL------- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 213 yRNVIDIQQggehgrtalhlaaiydheecariLITEFDACPRKPCNNGYYPIHEAA--KNASSKTMEVFFqwgeQRGCTr 290
Cdd:PHA03100 83 -TDVKEIVK-----------------------LLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLL----DNGAN- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 291 eemISFYDSEGNVPLHSAVHGG--DIKAVELCLKSGAKIStqqhdlstpvhlacaqgAIDIVKLMfemqpMEKRLCLSCT 368
Cdd:PHA03100 134 ---VNIKNSDGENLLHLYLESNkiDLKILKLLIDKGVDIN-----------------AKNRVNYL-----LSYGVPINIK 188
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631141 369 DVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDA 436
Cdd:PHA03100 189 DVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
109-257 |
1.08e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 55.77 E-value: 1.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 109 RLFMADNSRIALKDAKGRTAAHQAAARNRVNILRYIRDQN---GDFNAKDnaGNTPLHIAVESDAYDALDYLLSIPVDTG 185
Cdd:PHA02875 52 KLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGkfaDDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPD 129
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631141 186 VLNEKKQAPVHLATELNKVKSLRVMGQYRNVIDIQQGgeHGRTALHLAAIYDHEECARILI---TEFDACPRKPC 257
Cdd:PHA02875 130 IPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDC--CGCTPLIIAMAKGDIAICKMLLdsgANIDYFGKNGC 202
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
125-178 |
1.77e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 48.81 E-value: 1.77e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 442631141 125 GRTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLL 178
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
584-673 |
1.81e-07 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 50.11 E-value: 1.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 584 LQLAAMSGYTETIELLHSVHSHLlDQVDKDGNTALHLATMENKPHAISVLMSMGCKLVYNvLDMSAIDYAIYYKYPEAAL 663
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|
gi 442631141 664 AMVTHEERAN 673
Cdd:pfam12796 79 LLLEKGADIN 88
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
295-435 |
3.29e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 54.23 E-value: 3.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 295 SFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGaiDIVKLmfEMQPMEKRLCLSCTDVQKMT 374
Cdd:PHA02875 29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEG--DVKAV--EELLDLGKFADDVFYKDGMT 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631141 375 PLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKD 435
Cdd:PHA02875 105 PLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIED 165
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
126-399 |
5.39e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 53.46 E-value: 5.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 126 RTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLATELNKVK 205
Cdd:PHA02875 3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 206 S---LRVMGQYRNVIDIQQggehGRTALHLAAIYDHEECARILItEFDACPRKPCNNGYYPIHEAAKNASSKTMEVFFqw 282
Cdd:PHA02875 83 AveeLLDLGKFADDVFYKD----GMTPLHLATILKKLDIMKLLI-ARGADPDIPNTDKFSPLHLAVMMGDIKGIELLI-- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 283 gEQRGCTREEmisfyDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTqqhdlstpvhlacaqgaidivklmfemqpMEKR 362
Cdd:PHA02875 156 -DHKACLDIE-----DCCGCTPLIIAMAKGDIAICKMLLDSGANIDY-----------------------------FGKN 200
|
250 260 270
....*....|....*....|....*....|....*....
gi 442631141 363 LCLS--CTDVQKmtplhcasmfDHPDIVSYLVAEGADIN 399
Cdd:PHA02875 201 GCVAalCYAIEN----------NKIDIVRLFIKRGADCN 229
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
230-330 |
7.37e-07 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 48.19 E-value: 7.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 230 LHLAAIYDHEECARILItEFDACPRKPCNNGYYPIHEAAKNASSKTMEVFFqwgeqrgctrEEMISFYDSEGNVPLHSAV 309
Cdd:pfam12796 1 LHLAAKNGNLELVKLLL-ENGADANLQDKNGRTALHLAAKNGHLEIVKLLL----------EHADVNLKDNGRTALHYAA 69
|
90 100
....*....|....*....|.
gi 442631141 310 HGGDIKAVELCLKSGAKISTQ 330
Cdd:pfam12796 70 RSGHLEIVKLLLEKGADINVK 90
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
481-532 |
1.05e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 46.88 E-value: 1.05e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 442631141 481 SPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLL 532
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02736 |
PHA02736 |
Viral ankyrin protein; Provisional |
103-210 |
1.48e-06 |
|
Viral ankyrin protein; Provisional
Pssm-ID: 165103 [Multi-domain] Cd Length: 154 Bit Score: 49.10 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 103 NLDDFKRLFMADNSRIALK-DAKGRTAAHQAAARNRV---NILRYIRDQNGDFNAKDNA-GNTPLHIAVESDAYDALDYL 177
Cdd:PHA02736 32 DLLAFKNAISDENRYLVLEyNRHGKQCVHIVSNPDKAdpqEKLKLLMEWGADINGKERVfGNTPLHIAVYTQNYELATWL 111
|
90 100 110
....*....|....*....|....*....|....
gi 442631141 178 LSIP-VDTGVLNEKKQAPVHLATELNKVKSLRVM 210
Cdd:PHA02736 112 CNQPgVNMEILNYAFKTPYYVACERHDAKMMNIL 145
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
335-392 |
1.71e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 46.11 E-value: 1.71e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 442631141 335 STPVHLACAQGAIDIVKLMFEmqpmeKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLV 392
Cdd:pfam13637 2 LTALHAAAASGHLELLRLLLE-----KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
373-425 |
2.74e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 45.73 E-value: 2.74e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 442631141 373 MTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLI 425
Cdd:pfam13637 2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
542-608 |
4.47e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 51.05 E-value: 4.47e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631141 542 NESDGAGMTPLHISSQQGHTRVVQLLLNRGA---LLHRDhtGRNPLQLAAMSGYTETIELL--HSVHSHLLD 608
Cdd:PTZ00322 109 NCRDYDGRTPLHIACANGHVQVVRVLLEFGAdptLLDKD--GKTPLELAEENGFREVVQLLsrHSQCHFELG 178
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
263-429 |
6.02e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 49.99 E-value: 6.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 263 PIHEAAKNASSKTMEVFFQWGEQRGCTreemisFYdSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLAC 342
Cdd:PHA02875 71 ELHDAVEEGDVKAVEELLDLGKFADDV------FY-KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 343 AQGAIDIVKLMfemqpMEKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGW-KTV 421
Cdd:PHA02875 144 MMGDIKGIELL-----IDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKiDIV 218
|
....*...
gi 442631141 422 HLLIRLGA 429
Cdd:PHA02875 219 RLFIKRGA 226
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
367-438 |
1.14e-05 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 49.51 E-value: 1.14e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631141 367 CTDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAA 438
Cdd:PTZ00322 110 CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGANA 181
|
|
| TRPV2 |
cd22197 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2; TRPV2 is closely ... |
935-1072 |
2.77e-05 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2; TRPV2 is closely related to TRPV1, sharing high sequence identity (>50%), but TRPV2 shows a higher temperature threshold and sensitivity for activation than TRPV1. TRPV2 can be stimulated by ligands or lipids, and is involved in osmosensation and mechanosensation. TRPV2 is expressed in both neuronal and non-neuronal tissues, and it has been implicated in diverse physiological and pathophysiological processes, including cardiac-structure maintenance, innate immunity, and cancer. TRPV2 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411981 [Multi-domain] Cd Length: 640 Bit Score: 48.31 E-value: 2.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 935 LSWFRLLLFLQRFDQVGIYVVMFLE-ILQTLIKVLMVFSILIIAFGLAFYILLSKIIDPQPN------------------ 995
Cdd:cd22197 437 LGWLNLLYYTRGFQHTGIYSVMIQKvILRDLLRFLLVYLVFLFGFAVALVSLSREAPSPKAPednnstvteqptvgqeee 516
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631141 996 HLSFSNIPMSLLR--TFSMMLGELDFvgtyvntyyRDQLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNA 1072
Cdd:cd22197 517 PAPYRSILDASLElfKFTIGMGELAF---------QEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNHVADNS 586
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
222-353 |
3.49e-05 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 48.33 E-value: 3.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 222 GGEHGRTALHLAAIYDHEECARILItefdacpRKPCN------NGYYPIHEAAKNASSKTMEVFFQWGEqrgctreemIS 295
Cdd:PLN03192 554 GDSKGRTPLHIAASKGYEDCVLVLL-------KHACNvhirdaNGNTALWNAISAKHHKIFRILYHFAS---------IS 617
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 442631141 296 FYDSEGNVpLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLM 353
Cdd:PLN03192 618 DPHAAGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLL 674
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
373-403 |
4.65e-05 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 41.51 E-value: 4.65e-05
10 20 30
....*....|....*....|....*....|..
gi 442631141 373 MTPLHCAS-MFDHPDIVSYLVAEGADINALDK 403
Cdd:pfam00023 3 NTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
|
|
| PHA02743 |
PHA02743 |
Viral ankyrin protein; Provisional |
93-218 |
7.53e-05 |
|
Viral ankyrin protein; Provisional
Pssm-ID: 222925 [Multi-domain] Cd Length: 166 Bit Score: 44.42 E-value: 7.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 93 FRILRAAESGNLDDFKRLFMADNSRIALKDAKGRTAAHQAAARNRVNILRYIR---DQNGDFNAKD-NAGNTPLHIAVES 168
Cdd:PHA02743 25 LRICRTGNIYELMEVAPFISGDGHLLHRYDHHGRQCTHMVAWYDRANAVMKIEllvNMGADINARElGTGNTLLHIAAST 104
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 442631141 169 DAYDALDYLLSIP-VDTGVLNEKKQAPVHLATELNKVKSLRVMGQYRNVID 218
Cdd:PHA02743 105 KNYELAEWLCRQLgVNLGAINYQHETAYHIAYKMRDRRMMEILRANGAVCD 155
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
535-587 |
9.13e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 41.18 E-value: 9.13e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 442631141 535 EKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLH-RDHTGRNPLQLA 587
Cdd:pfam13857 3 EHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNlKDEEGLTALDLA 56
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
304-353 |
1.04e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 41.11 E-value: 1.04e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 442631141 304 PLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLM 353
Cdd:pfam13637 4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
120-165 |
1.17e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 41.18 E-value: 1.17e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 442631141 120 LKDAKGRTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIA 165
Cdd:pfam13857 11 RLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
548-600 |
1.18e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 41.11 E-value: 1.18e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 442631141 548 GMTPLHISSQQGHTRVVQLLLNRGA-LLHRDHTGRNPLQLAAMSGYTETIELLH 600
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGAdINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
371-400 |
1.74e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 39.88 E-value: 1.74e-04
10 20 30
....*....|....*....|....*....|
gi 442631141 371 QKMTPLHCASMFDHPDIVSYLVAEGADINA 400
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
580-633 |
1.91e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 40.34 E-value: 1.91e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 442631141 580 GRNPLQLAAMSGYTETIELLHSvHSHLLDQVDKDGNTALHLATMENKPHAISVL 633
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLE-KGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| TRPV4 |
cd22195 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 4; TRPV4 is expressed ... |
548-1099 |
2.39e-04 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 4; TRPV4 is expressed broadly in neuronal and non-neuronal cells. It is activated by various stimuli, including hypo-osmolarity, warm temperature, and chemical ligands. TRPV4 acts in physiological functions such as osmoregulation and thermoregulation. It also has a role in mechanosensation in the vascular endothelium and urinary tract, and in cell barrier formation in vascular and epidermal tissues. Knockout mice studies suggested the functional importance of TRPV4 in the central nervous system, nociception, and bone formation. TRPV4 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411979 [Multi-domain] Cd Length: 733 Bit Score: 45.61 E-value: 2.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 548 GMTPLHISSQQGHTRVVQLLLNRGALLHRDHTGRN---------------PLQLAAMSGYTETIE-LLHSVHSHL-LDQV 610
Cdd:cd22195 137 GQTALHIAIERRCKHYVELLVEKGADVHAQARGRFfqpkdeggyfyfgelPLSLAACTNQPDIVHyLTENAHKKAdLRRQ 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 611 DKDGNTALHLATmenkphAISVLMSMGCKLVYNVLDMSAIDYAIYYkyPEAALAMVTHEERANEVMalrsdkhpcvtlaL 690
Cdd:cd22195 217 DSRGNTVLHALV------AIADNTRENTKFVTKMYDLLLIKCAKLY--PDCNLEAILNNDGMSPLM-------------M 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 691 IASMPK--VFEAVQDKCITKANCKKDSKsfyiKYSFWPYQKtpeqIEAKRKEFNDPKWRPAPLAVVNTMVTHGRVE---- 764
Cdd:cd22195 276 AAKLGKigIFQHIIRREIKDEEARHLSR----KFKDWAYGP----VYSSLYDLSSLDTCGEEVSVLEILVYNSKIEnrhe 347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 765 -LLAHPLSQkYLQMKWNSYGK---YFHLANLLIYSIFLVFVTIYSSLmmnnielkagDNKTMSQYcnmgweqltmnlsqn 840
Cdd:cd22195 348 mLAVEPINE-LLRDKWRKFGAvsfYISVVSYLVAMIIFTLIAYYRPM----------EGTPPYPY--------------- 401
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 841 PSVASQIRLDSceERINRTTAILFCAVVIVVYIL-----LNSMreLIQIYQQKLHYILETVNLISWVLYISAL-----VM 910
Cdd:cd22195 402 RTTVDYLRLAG--EIITLLTGIFFFFTNIKDLFMkkcpgVNSL--FIDGSFQLLYFIYSVLVIVTAALYLAGIeaylaVM 477
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 911 VtpafqpdggintihysaasIAVFLSWFRLLLFLQRFDQVGIYVVMFLEIL-QTLIKVLMVFSILIIAFGLAFYILLSKI 989
Cdd:cd22195 478 V-------------------FALVLGWMNALYFTRGLKLTGTYSIMIQKILfKDLFRFLLVYLLFMIGYASALVSLLNPC 538
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 990 ------IDPQPN-----------HLSFSNIPMSLLRtFSMMLGELDFVgtyvntyyrDQLKVPMTSFLILSVFMILMPIL 1052
Cdd:cd22195 539 ptketcKEDSTNctvptypscrdSNTFSKFLLDLFK-LTIGMGDLEML---------NSAKYPAVFIILLVTYIILTFVL 608
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|
gi 442631141 1053 LMNLLIGL---AVGDIEsvRRNAQLKRLAMQVVLhTELERKLPhVWLQRV 1099
Cdd:cd22195 609 LLNMLIALmgeTVGQVS--KESKQIWKLQWATTI-LDIERSFP-VFLRKA 654
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
519-637 |
4.63e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 44.21 E-value: 4.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 519 AARYGRYNTVRQLLDSE-KGSFIINEsdgaGMTPLHISSQQGHTRVVQLLLNRGALLHRDHTG-RNPLQLAAMSGYTETI 596
Cdd:PHA02875 9 AILFGELDIARRLLDIGiNPNFEIYD----GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDiESELHDAVEEGDVKAV 84
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 442631141 597 ELLHSVHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMG 637
Cdd:PHA02875 85 EELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARG 125
|
|
| TRPV1-4 |
cd22193 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ... |
366-501 |
5.31e-04 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411977 [Multi-domain] Cd Length: 607 Bit Score: 44.40 E-value: 5.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 366 SCTDV--QKMTPLHCASMFDHPDIVSYLVAEGADINAL--------DKEH------RSPLLLAASRSGWKTVHLLIR--- 426
Cdd:cd22193 68 EYTDEyyEGQTALHIAIERRQGDIVALLVENGADVHAHakgrffqpKYQGegfyfgELPLSLAACTNQPDIVQYLLEneh 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 427 LGACISVKDAAARNVLHFVIM---NGGRLTDFAEQV--------ANCQTQAQLKLLLNEKdsmGCSPLHYASRDGHIRSL 495
Cdd:cd22193 148 QPADIEAQDSRGNTVLHALVTvadNTKENTKFVTRMydmilirgAKLCPTVELEEIRNND---GLTPLQLAAKMGKIEIL 224
|
....*.
gi 442631141 496 ENLIRL 501
Cdd:cd22193 225 KYILQR 230
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
368-586 |
5.49e-04 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 43.89 E-value: 5.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 368 TDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPL--LLAASRSGWKTVHLLIRLGACISvkdaaarnvlhfv 445
Cdd:PHA02946 68 TDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKIN------------- 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 446 imnggrltdfaeqvancqtqaqlklllNEKDSMGCSPLhYASRDGHIRSLENLIRLG--ACINLKNNNNESPLHFAARYG 523
Cdd:PHA02946 135 ---------------------------NSVDEEGCGPL-LACTDPSERVFKKIMSIGfeARIVDKFGKNHIHRHLMSDNP 186
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631141 524 RYNTVRQLLdseKGSFIINESDGAGMTPLHI--SSQQGHTRVVQLLLNRGALLHRDHTGRNPLQL 586
Cdd:PHA02946 187 KASTISWMM---KLGISPSKPDHDGNTPLHIvcSKTVKNVDIINLLLPSTDVNKQNKFGDSPLTL 248
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
226-279 |
6.21e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 38.79 E-value: 6.21e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 442631141 226 GRTALHLAAIYDHEECARILItEFDACPRKPCNNGYYPIHEAAKNASSKTMEVF 279
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
470-519 |
6.22e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.87 E-value: 6.22e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 442631141 470 LLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFA 519
Cdd:pfam13857 7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
143-198 |
9.40e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.48 E-value: 9.40e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 442631141 143 YIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLA 198
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
110-168 |
1.01e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 43.12 E-value: 1.01e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 442631141 110 LFMADNSRIALKDAKGRTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVES 168
Cdd:PHA03100 177 YLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILN 235
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
109-358 |
1.62e-03 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 42.32 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 109 RLFMADNSRIALKDAKGRTAAH-QAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHI--AVESDAYDALDYLLSIPVDTG 185
Cdd:PHA03095 67 RLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGADVN 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 186 VLNEKKQAPVHLATELNK--VKSLRVM---GQY-RNVIDIqqggehGRTALHLAAIY--DHEECARILItEFDACPRKPC 257
Cdd:PHA03095 147 ALDLYGMTPLAVLLKSRNanVELLRLLidaGADvYAVDDR------FRSLLHHHLQSfkPRARIVRELI-RAGCDPAATD 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 258 NNGYYPIHEAAKNASsktmevffqwgeqrgCTREEMISFY---------DSEGNVPLHSAVHGGDIKAVELCLKSGAKIS 328
Cdd:PHA03095 220 MLGNTPLHSMATGSS---------------CKRSLVLPLLiagisinarNRYGQTPLHYAAVFNNPRACRRLIALGADIN 284
|
250 260 270
....*....|....*....|....*....|
gi 442631141 329 TQQHDLSTPVHLACAQGAIDIVKLMFEMQP 358
Cdd:PHA03095 285 AVSSDGNTPLSLMVRNNNGRAVRAALAKNP 314
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
373-400 |
2.22e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 36.85 E-value: 2.22e-03
10 20
....*....|....*....|....*...
gi 442631141 373 MTPLHCASMFDHPDIVSYLVAEGADINA 400
Cdd:pfam13606 3 NTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| PHA02741 |
PHA02741 |
hypothetical protein; Provisional |
98-213 |
2.84e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 165108 [Multi-domain] Cd Length: 169 Bit Score: 40.03 E-value: 2.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 98 AAESGNLDDFKRL--FMADNSRIAL---KDAKGRTAAHQAAARNR----VNILRYIRDQNGDFNAKDNA-GNTPLHIAVE 167
Cdd:PHA02741 28 AARCGCFDIIARFtpFIRGDCHAAAlnaTDDAGQMCIHIAAEKHEaqlaAEIIDHLIELGADINAQEMLeGDTALHLAAH 107
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 442631141 168 SDAYDALDYLLSIP-VDTGVLNEKKQAPVHLATELNKVKSLRVMGQY 213
Cdd:PHA02741 108 RRDHDLAEWLCCQPgIDLHFCNADNKSPFELAIDNEDVAMMQILREI 154
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
16-179 |
3.16e-03 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 41.81 E-value: 3.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 16 LSPPDLMEAQPKLLPKPRSNSSGSTGRNSKYWIF---SMIIERSAgpkRI-------EIDGDDADTPLEAILPAE--PPA 83
Cdd:PTZ00322 1 MSFLVCSVASSAFAAQLFFGTEGSRKRRAKPISFermAAIQEEIA---RIdthlealEATENKDATPDHNLTTEEviDPV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 84 -------EVCLLrdspfrilraAESGNLDDFKRLFM--AD-NSRialkDAKGRTAAHQAAARNRVNILRYIRDQNGDFNA 153
Cdd:PTZ00322 78 vahmltvELCQL----------AASGDAVGARILLTggADpNCR----DYDGRTPLHIACANGHVQVVRVLLEFGADPTL 143
|
170 180
....*....|....*....|....*.
gi 442631141 154 KDNAGNTPLHIAVESDAYDALDYLLS 179
Cdd:PTZ00322 144 LDKDGKTPLELAEENGFREVVQLLSR 169
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
479-510 |
3.25e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 36.50 E-value: 3.25e-03
10 20 30
....*....|....*....|....*....|...
gi 442631141 479 GCSPLHYAS-RDGHIRSLENLIRLGACINLKNN 510
Cdd:pfam00023 2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
93-247 |
3.47e-03 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 41.78 E-value: 3.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 93 FRILRAAESGN---LDDFKRLFMADNsriaLKDAKGRTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESD 169
Cdd:PLN03192 527 SNLLTVASTGNaalLEELLKAKLDPD----IGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAK 602
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 170 AYDALDYL-----LSIPVDTGVLnekkqapVHLATELNKVKSLRVMgqYRNVIDIQQGGEHGRTALHLAAIYDHEECARI 244
Cdd:PLN03192 603 HHKIFRILyhfasISDPHAAGDL-------LCTAAKRNDLTAMKEL--LKQGLNVDSEDHQGATALQVAMAEDHVDMVRL 673
|
...
gi 442631141 245 LIT 247
Cdd:PLN03192 674 LIM 676
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
98-155 |
4.57e-03 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 37.79 E-value: 4.57e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 442631141 98 AAESGNLDDFKRLfmADNSRIALKDaKGRTAAHQAAARNRVNILRYIRDQNGDFNAKD 155
Cdd:pfam12796 37 AAKNGHLEIVKLL--LEHADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
|
|
| PHA02736 |
PHA02736 |
Viral ankyrin protein; Provisional |
440-572 |
4.69e-03 |
|
Viral ankyrin protein; Provisional
Pssm-ID: 165103 [Multi-domain] Cd Length: 154 Bit Score: 39.09 E-value: 4.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 440 NVLHFVIMNGG--RLTDFAEQVANCQtqaqlKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRL---GACINLKNN-NNE 513
Cdd:PHA02736 19 NILHYLCRNGGvtDLLAFKNAISDEN-----RYLVLEYNRHGKQCVHIVSNPDKADPQEKLKLLmewGADINGKERvFGN 93
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 514 SPLHFAARYGRYNTVRQLLDSEKGSF-IINEsdgAGMTPLHISSQQGHTRVVQLLLNRGA 572
Cdd:PHA02736 94 TPLHIAVYTQNYELATWLCNQPGVNMeILNY---AFKTPYYVACERHDAKMMNILRAKGA 150
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
548-572 |
4.82e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 35.73 E-value: 4.82e-03
10 20
....*....|....*....|....*.
gi 442631141 548 GMTPLHI-SSQQGHTRVVQLLLNRGA 572
Cdd:pfam00023 2 GNTPLHLaAGRRGNLEIVKLLLSKGA 27
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
368-412 |
6.11e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 36.17 E-value: 6.11e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 442631141 368 TDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLA 412
Cdd:pfam13857 12 LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
495-646 |
7.71e-03 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 40.62 E-value: 7.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631141 495 LENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLdseKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRgALL 574
Cdd:PLN03192 541 LEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLL---KHACNVHIRDANGNTALWNAISAKHHKIFRILYHF-ASI 616
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442631141 575 HRDHTGRNPLQLAAMSGYTETI-ELLHsvHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMGCKLVYNVLD 646
Cdd:PLN03192 617 SDPHAAGDLLCTAAKRNDLTAMkELLK--QGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
|
|
| |
