|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
368-634 |
2.90e-31 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 124.68 E-value: 2.90e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 368 TDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIM 447
Cdd:COG0666 17 LLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAAR 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 448 NGgrltdfaeqvancqTQAQLKLLL------NEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAAR 521
Cdd:COG0666 97 NG--------------DLEIVKLLLeagadvNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 522 YGRYNTVRQLLdsEKGsFIINESDGAGMTPLHISSQQGHTRVVQLLLNRGA-LLHRDHTGRNPLQLAAMSGYTETIELLH 600
Cdd:COG0666 163 NGNLEIVKLLL--EAG-ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAdVNAKDNDGKTALDLAAENGNLEIVKLLL 239
|
250 260 270
....*....|....*....|....*....|....
gi 442631147 601 SvHSHLLDQVDKDGNTALHLATMENKPHAISVLM 634
Cdd:COG0666 240 E-AGADLNAKDKDGLTALLLAAAAGAALIVKLLL 272
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
293-599 |
4.51e-30 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 121.21 E-value: 4.51e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 293 MISFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMFEMQPMEKRlclscTDVQK 372
Cdd:COG0666 13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA-----KDDGG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 373 MTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGAcisvkdaaarNVlhfvimnggrl 452
Cdd:COG0666 88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGA----------DV----------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 453 tdfaeqvancqtqaqlklllNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLL 532
Cdd:COG0666 147 --------------------NAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLL 206
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631147 533 dsEKGSfIINESDGAGMTPLHISSQQGHTRVVQLLLNRGALL-HRDHTGRNPLQLAAMSGYTETIELL 599
Cdd:COG0666 207 --EAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLnAKDKDGLTALLLAAAAGAALIVKLL 271
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
298-513 |
1.73e-27 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 113.90 E-value: 1.73e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 298 DSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMfemqpMEKRLCLSCTDVQKMTPLH 377
Cdd:COG0666 84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL-----LEAGADVNAQDNDGNTPLH 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 378 CASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRltdfae 457
Cdd:COG0666 159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNL------ 232
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 442631147 458 qvANCQTQAQLKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNE 513
Cdd:COG0666 233 --EIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLL 286
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
466-673 |
2.22e-27 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 113.51 E-value: 2.22e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 466 AQLKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLdsEKGsFIINESD 545
Cdd:COG0666 41 LLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLL--EAG-ADVNARD 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 546 GAGMTPLHISSQQGHTRVVQLLLNRGALLH-RDHTGRNPLQLAAMSGYTETIELL--HSVHshlLDQVDKDGNTALHLAT 622
Cdd:COG0666 118 KDGETPLHLAAYNGNLEIVKLLLEAGADVNaQDNDGNTPLHLAAANGNLEIVKLLleAGAD---VNARDNDGETPLHLAA 194
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 442631147 623 MENKPHAISVLMSMGCKL-VYNVLDMSAIDYAIYYKYPEAALAMVTHEERAN 673
Cdd:COG0666 195 ENGHLEIVKLLLEAGADVnAKDNDGKTALDLAAENGNLEIVKLLLEAGADLN 246
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
140-461 |
3.97e-26 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 109.66 E-value: 3.97e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 140 ILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLATELNKVKSLRVMGQYRNVIDI 219
Cdd:COG0666 1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 220 QQGGEHGRTALHLAAIYDHEECARILITefdacprkpcnngyypiHEAAKNASsktmevffqwgeqrgctreemisfyDS 299
Cdd:COG0666 81 NAKDDGGNTLLHAAARNGDLEIVKLLLE-----------------AGADVNAR-------------------------DK 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 300 EGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMfemqpMEKRLCLSCTDVQKMTPLHCA 379
Cdd:COG0666 119 DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL-----LEAGADVNARDNDGETPLHLA 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 380 SMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRLTDFAEQV 459
Cdd:COG0666 194 AENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273
|
..
gi 442631147 460 AN 461
Cdd:COG0666 274 AL 275
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
481-1056 |
5.88e-25 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 111.26 E-value: 5.88e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 481 SPLHYASRDGHIRSLENLIRLGACINL-KNNNNESPLHFAARYGRYNTVRQLLDSEKGsfIINE---SD-GAGMTPLHIS 555
Cdd:cd22192 19 SPLLLAAKENDVQAIKKLLKCPSCDLFqRGALGETALHVAALYDNLEAAVVLMEAAPE--LVNEpmtSDlYQGETALHIA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 556 SQQGHTRVVQLLLNRGA------------LLHRD---HTGRNPLQLAAMSGYTETIELLHSVHSHLLDQvDKDGNTALH- 619
Cdd:cd22192 97 VVNQNLNLVRELIARGAdvvspratgtffRPGPKnliYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQ-DSLGNTVLHi 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 620 LATMENKPHAisvlmsmgcKLVYNVLdmsaidyaiyykypeaaLAMVTHEERANEVMALRSDKHPCVTLALIASMPKVFE 699
Cdd:cd22192 176 LVLQPNKTFA---------CQMYDLI-----------------LSYDKEDDLQPLDLVPNNQGLTPFKLAAKEGNIVMFQ 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 700 -AVQDKCITKANCKKDSKSFYTM----------------VTHGRVELLA----HPLSQkYLQMKWNSYGKYFHLANLLIY 758
Cdd:cd22192 230 hLVQKRRHIQWTYGPLTSTLYDLteidswgdeqsvleliVSSKKREARKildvTPVKE-LVSLKWKRYGRPYFRILALLY 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 759 sifLVFVTIYSSLMMNNIELKAGDNKTMSQyCNMGWEQLTMNLS-QNPSvaSQIRLDSceERINrttaiLFCAVVIVVYI 837
Cdd:cd22192 309 ---LLYIIIFTLCCVYRPLKPRPENNTDPR-DITLYVQKTLQESyVTPK--DYLRLVG--ELIS-----VLGAIVILLLE 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 838 LLNSMRELIQIY--QQKL----HYILETVnliswvlyiSALVMVTPAFQ---PDGGINTIhysaaSIAVFLSWFRLLLFL 908
Cdd:cd22192 376 IPDILRVGVKRYfgQTVLggpfHVIIITY---------ACLVLLTLVLRltsLSGEVVPM-----SLALVLGWCNVMYFA 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 909 QRFDQVGIYVVMFLEIL-QTLIKVLMVFSILIIAFGLAFYILLsKIIDPQPNhLSFSNIPMSLLRTFSMMLGELDFVGTY 987
Cdd:cd22192 442 RGFQMLGPFTIMIQKIIfGDLMKFCWLMFVVILGFSSAFYMIF-QTEDPDSL-GHFYDFPMTLFSTFELFLGLIDGPANY 519
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442631147 988 vntyyrDQLKVPMTSFLIlSVFMILMPILLMNLLIGLaVGDieSVRRNAQ----LKRlaMQVVLHT-ELERKLP 1056
Cdd:cd22192 520 ------TVDLPFMYKVLY-TAFAVIAYLLMLNLLIAM-MGD--THWRVAHerdeLWR--AQVVATTlMLERRLP 581
|
|
| Ion_trans |
pfam00520 |
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ... |
813-1037 |
3.70e-24 |
|
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 102.73 E-value: 3.70e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 813 LDSCEERINRTTAILFCAVVIVVYILLNSMreLIQIYQQ--KLHYILETVNLISWVLYISALVMVTPAfqpdggiNTIHY 890
Cdd:pfam00520 21 LETYFQPEEPLTTVLEILDYVFTGIFTLEM--LLKIIAAgfKKRYFRSPWNILDFVVVLPSLISLVLS-------SVGSL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 891 SAASIAVFLSWFRLLLFLQRFDQVGIYVVMFLEILQTLIKVLMVFSILIIAFGLAFYILLSKI----IDPQPNHLSFSNI 966
Cdd:pfam00520 92 SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlktwENPDNGRTNFDNF 171
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631147 967 PMSLLRTFSMMLGElDFVGTYVNTYYRdqlKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQ 1037
Cdd:pfam00520 172 PNAFLWLFQTMTTE-GWGDIMYDTIDG---KGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
73-404 |
3.81e-21 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 95.41 E-value: 3.81e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 73 LEAILPAEPPAEVCLLRDSPFRILRAAESGNLDDFKRLFMADNSRIALKDAKGRTAAHQAAARNRVNILRYIRDQNGDFN 152
Cdd:COG0666 35 LLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVN 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 153 AKDNAGNTPLHIAVESDAYDALDYLLsipvdtgvlneKKQApvhlatelnkvkslrvmgqyrnviDIQQGGEHGRTALHL 232
Cdd:COG0666 115 ARDKDGETPLHLAAYNGNLEIVKLLL-----------EAGA------------------------DVNAQDNDGNTPLHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 233 AAIYDHEECARILItefdacprkpcNNGyypiheAAKNASsktmevffqwgeqrgctreemisfyDSEGNVPLHSAVHGG 312
Cdd:COG0666 160 AAANGNLEIVKLLL-----------EAG------ADVNAR-------------------------DNDGETPLHLAAENG 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 313 DIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMfemqpMEKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLV 392
Cdd:COG0666 198 HLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLL-----LEAGADLNAKDKDGLTALLLAAAAGAALIVKLLL 272
|
330
....*....|..
gi 442631147 393 AEGADINALDKE 404
Cdd:COG0666 273 LALLLLAAALLD 284
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
289-587 |
1.20e-20 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 96.19 E-value: 1.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 289 TREEMISFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLmfemqpmekrLCLSCT 368
Cdd:PHA02874 23 NKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKL----------LIDNGV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 369 DVQkMTPLHCAsmfdHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAarnvlhfvimn 448
Cdd:PHA02874 93 DTS-ILPIPCI----EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDN----------- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 449 ggrltdfaeqvancqtqaqlklllnekdsmGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTV 528
Cdd:PHA02874 157 ------------------------------GCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACI 206
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 529 RQLLDSekGSFIINESDGaGMTPLHISSQqgHTR-VVQLLLNRGALLHRDHTGRNPLQLA 587
Cdd:PHA02874 207 KLLIDH--GNHIMNKCKN-GFTPLHNAII--HNRsAIELLINNASINDQDIDGSTPLHHA 261
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
473-1024 |
1.35e-19 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 94.76 E-value: 1.35e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 473 NEKDSMGCSPLHYASRDGHIRSLENLirlgacinLKNNNN-----ESPLHfAARYGRYNTVRQLL------DSEKGS-FI 540
Cdd:TIGR00870 46 NCPDRLGRSALFVAAIENENLELTEL--------LLNLSCrgavgDTLLH-AISLEYVDAVEAILlhllaaFRKSGPlEL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 541 INESDG----AGMTPLHISSQQGHTRVVQLLLNRGALLH----------RDHT-----GRNPLQLAAMSGYTETIELLhS 601
Cdd:TIGR00870 117 ANDQYTseftPGITALHLAAHRQNYEIVKLLLERGASVParacgdffvkSQGVdsfyhGESPLNAAACLGSPSIVALL-S 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 602 VHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMGCK-LVYNVLDMSAIDY---AIYYKYPEAALAMVTHEER---ANE 674
Cdd:TIGR00870 196 EDPADILTADSLGNTLLHLLVMENEFKAEYEELSCQMYnFALSLLDKLRDSKeleVILNHQGLTPLKLAAKEGRivlFRL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 675 VMALRSDK-----HPC--VTLALI--ASMPkvfeavqdkcitkaNCKKDSKSFYTMVTHG--------RVELLAHPLSqK 737
Cdd:TIGR00870 276 KLAIKYKQkkfvaWPNgqQLLSLYwlEELD--------------GWRRKQSVLELIVVFViglkfpelSDMYLIAPLS-R 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 738 YLQMKWNSYGK-YFHlANLLIYSIFLVFVTIysslmmnnielKAGDNKTMSQYCNMGWEQLTMNLSQNPSVASqIRLDSC 816
Cdd:TIGR00870 341 LGQFKWKPFIKfIFH-SASYLYFLYLIIFTS-----------VAYYRPTRTDLRVTGLQQTPLEMLIVTWVDG-LRLGEE 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 817 EErinrttaILFCAVVIVVYILLNSMReliqiyQQKLHYILETVNL--ISWVLYISALVMVTPAFQPdgGINTIHYSAA- 893
Cdd:TIGR00870 408 KL-------IWLGGIFEYIHQLWNILD------FGMNSFYLATFLDrpFAILFVTQAFLVLREHWLR--FDPTLIEEALf 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 894 SIAVFLSWFRLLLFLQRFDQVGIYVVMFLE-ILQTLIKVLMVFSILIIAFGLAFYILLS--------------KIIDPQP 958
Cdd:TIGR00870 473 AFALVLSWLNLLYIFRGNQHLGPLQIMIGRmILGDILRFLFIYAVVLFGFACGLNQLYQyydelklnecsnphARSCEKQ 552
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631147 959 NHlSFSNIPMSLLRTF--SMMLGELDFvgtyvntyyRDQLKVPMTSFLILSVFMILMPILLMNLLIGL 1024
Cdd:TIGR00870 553 GN-AYSTLFETSQELFwaIIGLGDLLA---------NEHKFTEFVGLLLFGAYNVIMYILLLNMLIAM 610
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
513-1056 |
1.50e-18 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 91.09 E-value: 1.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 513 ESPLHFAARY---GRYNTVRQLLDSEKGSFIINESDGA--------GMTPLHISSQQGHTRVVQLLLNRGALLHRDHTGR 581
Cdd:cd21882 27 KTCLHKAALNlndGVNEAIMLLLEAAPDSGNPKELVNApctdefyqGQTALHIAIENRNLNLVRLLVENGADVSARATGR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 582 --------------NPLQLAAMSGYTETIELL--HSVHSHLLDQVDKDGNTALHL------ATMENKPHAISV---LMSM 636
Cdd:cd21882 107 ffrkspgnlfyfgeLPLSLAACTNQEEIVRLLleNGAQPAALEAQDSLGNTVLHAlvlqadNTPENSAFVCQMynlLLSY 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 637 GCKL--------VYNVLDMSAIDYAIyykyPEAALAMVTH--EERANEVMALRSDKHPCVTLALIASmpkvfeAVQDkcI 706
Cdd:cd21882 187 GAHLdptqqleeIPNHQGLTPLKLAA----VEGKIVMFQHilQREFSGPYQPLSRKFTEWTYGPVTS------SLYD--L 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 707 TKANCKKDSKSFYTMVTHGRVE-----LLAHPLsQKYLQMKWNSYGK---YFHLANLLIYSIFLVFVTIYSSLmmnniel 778
Cdd:cd21882 255 SEIDSWEKNSVLELIAFSKKREarhqmLVQEPL-NELLQEKWDRYGRpyfCFNFACYLLYMIIFTVCAYYRPL------- 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 779 kagdnktmsqycnmgwEQLTMNLSQNPSVASQIRLdsceerinrTTAILfcAVVIVVYILLnsmRELIQIYQQKLHYILE 858
Cdd:cd21882 327 ----------------KDRPANQEAKATFGDSIRL---------VGEIL--TVLGGVYILL---GEIPYFFRRRLSRWFG 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 859 TVNLISWVLYI--SALVMVTPAFQPdggINTIHYSAA-SIAVFLSWFRLLLFLQRFDQVGIYVVMFLE-ILQTLIKVLMV 934
Cdd:cd21882 377 FLDSYFEILFItqALLVLLSMVLRF---METEGYVVPlVFSLVLGWCNVLYYTRGFQMLGIYTVMIQKmILRDLMRFCWV 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 935 FSILIIAFGLAFYILLSkiiDPQPNHL-SFSNIPMSLLRTFSMMLGELDFVGTYvntyyrdQLKVPMTSFLILSVFMILM 1013
Cdd:cd21882 454 YLVFLFGFASAFVILFQ---TEDPNKLgEFRDYPDALLELFKFTIGMGDLPFNE-------NVDFPFVYLILLLAYVILT 523
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 442631147 1014 PILLMNLLIGLAVgdiESVRRNAQ----LKRLamQVVLHT-ELERKLP 1056
Cdd:cd21882 524 YLLLLNMLIALMG---ETVNRVAQesdeIWKL--QKAITTlMLERKYP 566
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
95-336 |
6.03e-18 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 85.78 E-value: 6.03e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 95 ILRAAESGNLDDFKRLfMADNSRIALKDAKGRTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDAL 174
Cdd:COG0666 91 LHAAARNGDLEIVKLL-LEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 175 DYLLSIPVDtgvlnekkqapvhlatelnkvkslrvmgqyrnvIDIQqgGEHGRTALHLAAIYDHEECARILItEFDACPR 254
Cdd:COG0666 170 KLLLEAGAD---------------------------------VNAR--DNDGETPLHLAAENGHLEIVKLLL-EAGADVN 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 255 KPCNNGYYPIHEAAKNASSKTMEVFFQWGEQrgctreemISFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDL 334
Cdd:COG0666 214 AKDNDGKTALDLAAENGNLEIVKLLLEAGAD--------LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
|
..
gi 442631147 335 ST 336
Cdd:COG0666 286 LT 287
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
294-570 |
7.23e-17 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 85.08 E-value: 7.23e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 294 ISFYDSEGNVPLHSAVHGG---DIKAVELCLKSGAKISTQQHDLSTPVHL-ACAQGAIDIVKLMFEMQpmekrlclscTD 369
Cdd:PHA03095 40 VNFRGEYGKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHLyLYNATTLDVIKLLIKAG----------AD 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 370 VQK-----MTPLH--CASMFDHPDIVSYLVAEGADINALDKEHRSPL--LLAASRSGWKTVHLLIRLGACISVKDAAARN 440
Cdd:PHA03095 110 VNAkdkvgRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLIDAGADVYAVDDRFRS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 441 VLHFvimnggrltdFAEqvaNCQTQAQ-LKLLL------NEKDSMGCSPLHYASRDGHIRS--LENLIRLGACINLKNNN 511
Cdd:PHA03095 190 LLHH----------HLQ---SFKPRARiVRELIragcdpAATDMLGNTPLHSMATGSSCKRslVLPLLIAGISINARNRY 256
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 442631147 512 NESPLHFAARYGRYNTVRQLLdseKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNR 570
Cdd:PHA03095 257 GQTPLHYAAVFNNPRACRRLI---ALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAK 312
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
482-662 |
7.45e-17 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 82.69 E-value: 7.45e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 482 PLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLdseKGSFIINESDGAGMTPLHISSQQGHT 561
Cdd:COG0666 24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLL---AAGADINAKDDGGNTLLHAAARNGDL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 562 RVVQLLLNRGA-LLHRDHTGRNPLQLAAMSGYTETIELLhsvhshL-----LDQVDKDGNTALHLATMENKPHAISVLMS 635
Cdd:COG0666 101 EIVKLLLEAGAdVNARDKDGETPLHLAAYNGNLEIVKLL------LeagadVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174
|
170 180
....*....|....*....|....*...
gi 442631147 636 MGCKL-VYNVLDMSAIDYAIYYKYPEAA 662
Cdd:COG0666 175 AGADVnARDNDGETPLHLAAENGHLEIV 202
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
483-572 |
1.26e-16 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 75.92 E-value: 1.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 483 LHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDsekgsFIINESDGAGMTPLHISSQQGHTR 562
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-----HADVNLKDNGRTALHYAARSGHLE 75
|
90
....*....|
gi 442631147 563 VVQLLLNRGA 572
Cdd:pfam12796 76 IVKLLLEKGA 85
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
303-534 |
1.38e-16 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 83.56 E-value: 1.38e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 303 VPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAI-----DIVKLMfemqpMEKRLCLSCTDVQKMTPLH 377
Cdd:PHA03100 37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLL-----LEYGANVNAPDNNGITPLL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 378 CASM--FDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKT--VHLLIRLGACISVKdaaarNVLHFVIMNGgrlt 453
Cdd:PHA03100 112 YAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLLIDKGVDINAK-----NRVNYLLSYG---- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 454 dfaeqvancqtqaqlkLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLD 533
Cdd:PHA03100 183 ----------------VPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
|
.
gi 442631147 534 S 534
Cdd:PHA03100 247 N 247
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
305-402 |
6.95e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 71.30 E-value: 6.95e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 305 LHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMFEMQPMEKRLclsctdvQKMTPLHCASMFDH 384
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD-------NGRTALHYAARSGH 73
|
90
....*....|....*...
gi 442631147 385 PDIVSYLVAEGADINALD 402
Cdd:pfam12796 74 LEIVKLLLEKGADINVKD 91
|
|
| TRPV3 |
cd22194 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ... |
503-1071 |
7.62e-15 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411978 [Multi-domain] Cd Length: 680 Bit Score: 79.42 E-value: 7.62e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 503 ACINLKNNNNEsplhfaarygrynTVRQLLDSEKGSFI----IN----ESDGAGMTPLHISSQQGHTRVVQLLLNRGALL 574
Cdd:cd22194 101 ALLNINENTKE-------------IVRILLAFAEENGIldrfINaeytEEAYEGQTALNIAIERRQGDIVKLLIAKGADV 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 575 HRDHTGR---------------NPLQLAAMSGYTETIELLHSVHSHLLDQVDKDGNTALHLATM--ENKPHAISVLMSMG 637
Cdd:cd22194 168 NAHAKGVffnpkykhegfyfgeTPLALAACTNQPEIVQLLMEKESTDITSQDSRGNTVLHALVTvaEDSKTQNDFVKRMY 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 638 CKL-----------VYNVLDMSAIDYAIYYKYPEAALAMVTHEERANEVMALrSDKHpcVTLAliasMPKVFEAVQDkcI 706
Cdd:cd22194 248 DMIllksenknletIRNNEGLTPLQLAAKMGKAEILKYILSREIKEKPNRSL-SRKF--TDWA----YGPVSSSLYD--L 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 707 TKANCKKDSKSF----YTMVTHGRVELLA-HPLsQKYLQMKWNSYGKYFHLANLLIYSIFLVFVTIYSSLmmnnielKAG 781
Cdd:cd22194 319 TNVDTTTDNSVLeiivYNTNIDNRHEMLTlEPL-HTLLHMKWKKFARYMFFISFLFYFFYNITLTLVSYY-------RPR 390
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 782 DNKTMSQYCN----MGWEQLTmnlsqnpsvaSQIrldsceerinrttAILFCAVvivvYILLNSMRELIQIYQQKLHYIL 857
Cdd:cd22194 391 EDEDPPHPLAlshkMGWLQLL----------GQM-------------FVLIWAT----CLSVKEGIAIFLLRPSDLKSIL 443
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 858 EtvnlISW---VLYISALVMVTPAFQPDGGInTIHYSAASIAVFLSWFRLLLFLQRFDQVGIYVVMFLE-ILQTLIKVLM 933
Cdd:cd22194 444 S----DAWfhiLFFIQAVLVIVSVFLYLFAY-KEYLACLVLAMALGWANMLYYTRGFQSLGIYSVMIQKvILNDVLKFLL 518
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 934 VFSILIIAFGLAFYILLSKIIDPQPNHlSFSNIPMSLLRTFSMMLGELDFVGTYVNTYyrdqlkvPMTSFLILSVFMILM 1013
Cdd:cd22194 519 VYILFLLGFGVALASLIEDCPDDSECS-SYGSFSDAVLELFKLTIGLGDLEIQQNSKY-------PILFLLLLITYVILT 590
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631147 1014 PILLMNLLIGLAVGDIESVRRNAQ----LKRlAMQVVlhtELERKLPhVWLQRvdKMELIEY 1071
Cdd:cd22194 591 FVLLLNMLIALMGETVENVSKESEriwrLQR-ARTIL---EFEKSLP-EWLRK--RFRLGEL 645
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
516-599 |
1.06e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 70.53 E-value: 1.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 516 LHFAARYGRYNTVRQLLDSEKGsfiINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLHRDHtGRNPLQLAAMSGYTET 595
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGAD---ANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN-GRTALHYAARSGHLEI 76
|
....
gi 442631147 596 IELL 599
Cdd:pfam12796 77 VKLL 80
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
314-572 |
1.12e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 77.78 E-value: 1.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 314 IKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMFEmqpmeKRLCLSCTDVQKMTPLHCASMFDH-----PDIV 388
Cdd:PHA03100 15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLD-----NGADINSSTKNNSTPLHYLSNIKYnltdvKEIV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 389 SYLVAEGADINALDKEHRSPLLLAASRS--GWKTVHLLIRLGACISVKDAAARNVLHFVIMNggrltdfaeqvaNCQTQA 466
Cdd:PHA03100 90 KLLLEYGANVNAPDNNGITPLLYAISKKsnSYSIVEYLLDNGANVNIKNSDGENLLHLYLES------------NKIDLK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 467 QLKLLL------NEKDSmgcsplhyasrdghirsLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDseKGSFI 540
Cdd:PHA03100 158 ILKLLIdkgvdiNAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLD--LGANP 218
|
250 260 270
....*....|....*....|....*....|..
gi 442631147 541 iNESDGAGMTPLHISSQQGHTRVVQLLLNRGA 572
Cdd:PHA03100 219 -NLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
374-638 |
9.32e-13 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 71.98 E-value: 9.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 374 TPLH-CASMFDHP--DIVSYLVAEGADINALDKEHRSPL-LLAASRSGWKTVHLLIRLGACISVKDAAARNVLHfvimng 449
Cdd:PHA03095 49 TPLHlYLHYSSEKvkDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLH------ 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 450 grltdfaeqvancqtqaqlklllnekdsmgcspLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYN--T 527
Cdd:PHA03095 123 ---------------------------------VYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANveL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 528 VRQLLDseKGSFIINeSDGAGMTPLHISSQQGHTR--VVQLLLNRGA-LLHRDHTGRNPLQLAAMSGYTETIELLHSVHS 604
Cdd:PHA03095 170 LRLLID--AGADVYA-VDDRFRSLLHHHLQSFKPRarIVRELIRAGCdPAATDMLGNTPLHSMATGSSCKRSLVLPLLIA 246
|
250 260 270
....*....|....*....|....*....|....*
gi 442631147 605 HL-LDQVDKDGNTALHLATMENKPHAISVLMSMGC 638
Cdd:PHA03095 247 GIsINARNRYGQTPLHYAAVFNNPRACRRLIALGA 281
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
479-694 |
1.19e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 68.09 E-value: 1.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 479 GCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDSekGSFIINESDGAGMTPLHISSQQ 558
Cdd:PHA02875 35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDL--GKFADDVFYKDGMTPLHLATIL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 559 GHTRVVQLLLNRGALLHRDHTGR-NPLQLAAMSGYTETIELLHSvHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMG 637
Cdd:PHA02875 113 KKLDIMKLLIARGADPDIPNTDKfSPLHLAVMMGDIKGIELLID-HKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSG 191
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 442631147 638 CKLVY--NVLDMSAIDYAIYYKYPEAALAMVTHEERANEVMALRSDKhpCVTLALIASM 694
Cdd:PHA02875 192 ANIDYfgKNGCVAALCYAIENNKIDIVRLFIKRGADCNIMFMIEGEE--CTILDMICNM 248
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
387-599 |
2.07e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 67.38 E-value: 2.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 387 IVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRLTDFAEQVancqtqa 466
Cdd:PHA03100 17 NIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDVKEIV------- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 467 qlKLLL------NEKDSMGCSPLHYAS--RDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNT--VRQLLDseK 536
Cdd:PHA03100 90 --KLLLeyganvNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLLID--K 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631147 537 GSFI---------------INESDGAGMTPLHISSQQGHTRVVQLLLNRGALLH-RDHTGRNPLQLAAMSGYTETIELL 599
Cdd:PHA03100 166 GVDInaknrvnyllsygvpINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNlVNKYGDTPLHIAILNNNKEIFKLL 244
|
|
| TRPV1 |
cd22196 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ... |
501-1024 |
2.42e-11 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411980 [Multi-domain] Cd Length: 649 Bit Score: 67.91 E-value: 2.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 501 LGACINLKNNNNESPLHFAARYGRYNTVRQLLDSEkgsfiINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLH----- 575
Cdd:cd22196 52 LKAMLNLHNGQNDTISLLLDIAEKTGNLKEFVNAA-----YTDSYYKGQTALHIAIERRNMHLVELLVQNGADVHarasg 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 576 ---RDHTGRN-------PLQLAAMSGYTETIE-LLHSVHSHL-LDQVDKDGNTALH--LATMENKPHAISVLMSMgcklv 641
Cdd:cd22196 127 effKKKKGGPgfyfgelPLSLAACTNQLDIVKfLLENPHSPAdISARDSMGNTVLHalVEVADNTPENTKFVTKM----- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 642 YNVLDMSAIDYaiyykYPEAALamvthEERANevmalrsdKHPCVTLALIASMPK--VFEAVQDKCITKANCKKDSKSF- 718
Cdd:cd22196 202 YNEILILGAKI-----RPLLKL-----EEITN--------KKGLTPLKLAAKTGKigIFAYILGREIKEPECRHLSRKFt 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 719 ------------------------------YTMVTHGRVE-LLAHPLSqKYLQMKWNSYGKYFHLANLLIYSIFLVFVTI 767
Cdd:cd22196 264 ewaygpvhsslydlssidtyeknsvleiiaYSSETPNRHEmLLVEPLN-KLLQDKWDKFVKRIFYFNFFVYFIYMIIFTL 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 768 ysslmmnnielkAGDNKTmsqycnmgwEQLTMNLSQNPSVASQIRLDSceERINRTTAILFCAVVIVVYILLNSMRE--L 845
Cdd:cd22196 343 ------------AAYYRP---------VNKTPPFPIENTTGEYLRLTG--EIISVSGGVYFFFRGIQYFLQRRPSLKklI 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 846 IQIYQQKLHYILETVNLISWVLYISAlvmvtpafqpdggiNTIHYSAASIAVFLSWFRLLLFLQRFDQVGIYVVMFLE-I 924
Cdd:cd22196 400 VDSYCEILFFVQSLFLLASTVLYFCG--------------RNEYVAFMVISLALGWANVLYYTRGFQQMGIYSVMIQKmI 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 925 LQTLIKVLMVFSILIIAFGLAFYILL------------SKIIDPQPNHLSFSNIPMSLLR--TFSMMLGELDFVgtyvnt 990
Cdd:cd22196 466 LRDICRFLFVYLVFLFGFSAALVTLIedgppkgdvntsQKECVCKSGYNSYNSLYSTCLElfKFTIGMGDLEFT------ 539
|
570 580 590
....*....|....*....|....*....|....
gi 442631147 991 yyrDQLKVPMTSFLILSVFMILMPILLMNLLIGL 1024
Cdd:cd22196 540 ---ENYKFKEVFIFLLISYVILTYILLLNMLIAL 570
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
95-183 |
2.45e-11 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 60.90 E-value: 2.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 95 ILRAAESGNLDDFKRLFMAdNSRIALKDAKGRTAAHQAAARNRVNILRYIRDqNGDFNAKDNaGNTPLHIAVESDAYDAL 174
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLEN-GADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIV 77
|
....*....
gi 442631147 175 DYLLSIPVD 183
Cdd:pfam12796 78 KLLLEKGAD 86
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
162-246 |
2.52e-11 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 60.90 E-value: 2.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 162 LHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLATELNKVKSLRVMGQYRNVidiqQGGEHGRTALHLAAIYDHEEC 241
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV----NLKDNGRTALHYAARSGHLEI 76
|
....*
gi 442631147 242 ARILI 246
Cdd:pfam12796 77 VKLLL 81
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
84-522 |
3.88e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 67.40 E-value: 3.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 84 EVCLlrdspfRILRAAESGNLDDFKRLfmaDNSRIALKDAKGRTAahqaaaRNRVNILRYIRDQNGDFNAKDNAGNTPLH 163
Cdd:PHA02876 119 EACI------HILKEAISGNDIHYDKI---NESIEYMKLIKERIQ------QDELLIAEMLLEGGADVNAKDIYCITPIH 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 164 IAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLATELNKVKSLRvmgqyrnvidiqqggehgrtalhlaAIYDHeecar 243
Cdd:PHA02876 184 YAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIK-------------------------AIIDN----- 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 244 ilitefdacpRKPCNNGYYPIHEAAKNASSKTMEVFFQWGEQrgctreemISFYDSEGNVPLHSAVHGGDI-KAVELCLK 322
Cdd:PHA02876 234 ----------RSNINKNDLSLLKAIRNEDLETSLLLYDAGFS--------VNSIDDCKNTPLHHASQAPSLsRLVPKLLE 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 323 SGAKISTQQHDLSTPVHLACAQGaidivklmFEMQPMEKRLCL----SCTDVQKMTPLHCASMFD-HPDIVSYLVAEGAD 397
Cdd:PHA02876 296 RGADVNAKNIKGETPLYLMAKNG--------YDTENIRTLIMLgadvNAADRLYITPLHQASTLDrNKDIVITLLELGAN 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 398 INALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRLTdfaeqvaNCQTQAQLKLLLNEKDS 477
Cdd:PHA02876 368 VNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYM-------SVKTLIDRGANVNSKNK 440
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 442631147 478 MGCSPLHYASRDG-HIRSLENLIRLGACINLKNNNNESPLHFAARY 522
Cdd:PHA02876 441 DLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALEY 486
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
468-660 |
4.68e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 66.23 E-value: 4.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 468 LKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYgRYN------TVRQLLdsEKGSfII 541
Cdd:PHA03100 24 EDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNI-KYNltdvkeIVKLLL--EYGA-NV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 542 NESDGAGMTPLH--ISSQQGHTRVVQLLLNRGALLH-RDHTGRNPLQLAAMSGYTET------------------IELLH 600
Cdd:PHA03100 100 NAPDNNGITPLLyaISKKSNSYSIVEYLLDNGANVNiKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLL 179
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631147 601 SVHSHLlDQVDKDGNTALHLATMENKPHAISVLMSMGCKL-VYNVLDMSAIDYAIYYKYPE 660
Cdd:PHA03100 180 SYGVPI-NIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPnLVNKYGDTPLHIAILNNNKE 239
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
379-583 |
4.76e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 66.17 E-value: 4.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 379 ASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGgrltdfaeQ 458
Cdd:PHA02875 9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEG--------D 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 459 VANCQTQAQLKLLLNE---KDSMgcSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDSE 535
Cdd:PHA02875 81 VKAVEELLDLGKFADDvfyKDGM--TPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHK 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 442631147 536 KgsfIINESDGAGMTPLHISSQQGHTRVVQLLLNRGAllHRDHTGRNP 583
Cdd:PHA02875 159 A---CLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA--NIDYFGKNG 201
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
130-446 |
1.12e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 65.29 E-value: 1.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 130 HQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNE-KKQAPVHLATELNKVKSLr 208
Cdd:PHA02878 42 HQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTlVAIKDAFNNRNVEIFKII- 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 209 VMGQYRNV--IDIQQGGEHGRTALHLAAIydheecARILITEFDACPRKPCNNGYYPIHEAAKNASSKTMEVFFQWGEQr 286
Cdd:PHA02878 121 LTNRYKNIqtIDLVYIDKKSKDDIIEAEI------TKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGAN- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 287 gctreemISFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQ-GAIDIVKLMfemqpMEKRLCL 365
Cdd:PHA02878 194 -------VNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLL-----LEHGVDV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 366 SC-TDVQKMTPLHCAsmFDHPDIVSYLVAEGADINALDKEHRSPLLLAA-SRSGWKTVHLLIRLGACISVKDAAARNVLH 443
Cdd:PHA02878 262 NAkSYILGLTALHSS--IKSERKLKLLLEYGADINSLNSYKLTPLSSAVkQYLCINIGRILISNICLLKRIKPDIKNSEG 339
|
...
gi 442631147 444 FVI 446
Cdd:PHA02878 340 FID 342
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
161-412 |
2.78e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 63.83 E-value: 2.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 161 PLHIAVESDAYDALDYLLSIPVDTGVLnekkqaPVhlaTELNK--VKSLRVMGqyrnvIDIQQGGEHGRTALHLAAIYDH 238
Cdd:PHA02874 71 PLLTAIKIGAHDIIKLLIDNGVDTSIL------PI---PCIEKdmIKTILDCG-----IDVNIKDAELKTFLHYAIKKGD 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 239 EECARILItEFDACPRKPCNNGYYPIHEAAKNASSKTMEVFFQWGeqrgctreEMISFYDSEGNVPLHSAVHGGDIKAVE 318
Cdd:PHA02874 137 LESIKMLF-EYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKG--------AYANVKDNNGESPLHNAAEYGDYACIK 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 319 LCLKSGAKISTQQHDLSTPVHLACAQGAiDIVKLMFEMQpmekrlCLSCTDVQKMTPLHCAsmFDHP---DIVSYLVAEG 395
Cdd:PHA02874 208 LLIDHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLINNA------SINDQDIDGSTPLHHA--INPPcdiDIIDILLYHK 278
|
250
....*....|....*..
gi 442631147 396 ADINALDKEHRSPLLLA 412
Cdd:PHA02874 279 ADISIKDNKGENPIDTA 295
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
303-532 |
3.24e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 64.13 E-value: 3.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 303 VPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQG------------------------------------- 345
Cdd:PHA02878 39 IPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPnklgmkemirsinkcsvfytlvaikdafnnrnveifk 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 346 -----------AIDIVKL-----MFEMQPMEKRLCLS-CTDVQKM------TPLHCASMFDHPDIVSYLVAEGADINALD 402
Cdd:PHA02878 119 iiltnrykniqTIDLVYIdkkskDDIIEAEITKLLLSyGADINMKdrhkgnTALHYATENKDQRLTELLLSYGANVNIPD 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 403 KEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFvimnggrltdfaeQVANCQTQAQLKLLL------NEKD 476
Cdd:PHA02878 199 KTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHI-------------SVGYCKDYDILKLLLehgvdvNAKS 265
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 442631147 477 S-MGCSPLHYASRDGhiRSLENLIRLGACINLKNNNNESPLHFAAR-YGRYNTVRQLL 532
Cdd:PHA02878 266 YiLGLTALHSSIKSE--RKLKLLLEYGADINSLNSYKLTPLSSAVKqYLCINIGRILI 321
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
336-653 |
3.97e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 64.31 E-value: 3.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 336 TPVHLACAQGAIDIVKLMFEMQPMekrlCLSCTDVQKMTPLHCASMFdhPDIVSYLVAEGADINALDKEHRSPLLLAASR 415
Cdd:PHA02876 43 TAIHQALQLRQIDIVEEIIQQNPE----LIYITDHKCHSTLHTICII--PNVMDIVISLTLDCDIILDIKYASIILNKHK 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 416 SGWKTVHLLirlgacisvKDAAARNVLHFVIMNggRLTDFAEQVANCQTQAQLKLL---------LNEKDSMGCSPLHYA 486
Cdd:PHA02876 117 LDEACIHIL---------KEAISGNDIHYDKIN--ESIEYMKLIKERIQQDELLIAemlleggadVNAKDIYCITPIHYA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 487 SRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDSEK--------------------------GSFI 540
Cdd:PHA02876 186 AERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSninkndlsllkairnedletslllydAGFS 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 541 INESDGAGMTPLHISSQQGH-TRVVQLLLNRGALLH-RDHTGRNPLQLAAMSGY-TETIELLHSVHSHlLDQVDKDGNTA 617
Cdd:PHA02876 266 VNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNaKNIKGETPLYLMAKNGYdTENIRTLIMLGAD-VNAADRLYITP 344
|
330 340 350
....*....|....*....|....*....|....*...
gi 442631147 618 LHLA-TMENKPHAISVLMSMGCKL-VYNVLDMSAIDYA 653
Cdd:PHA02876 345 LHQAsTLDRNKDIVITLLELGANVnARDYCDKTPIHYA 382
|
|
| TRPV1-4 |
cd22193 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ... |
501-1066 |
4.01e-10 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411977 [Multi-domain] Cd Length: 607 Bit Score: 64.05 E-value: 4.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 501 LGACINLKNNNNEsplhfaarygrynTVRQLLDSEKGSFIINESDGA--------GMTPLHISSQQGHTRVVQLLLNRGA 572
Cdd:cd22193 34 MKALLNLNPGTND-------------TIRILLDIAEKTDNLKRFINAeytdeyyeGQTALHIAIERRQGDIVALLVENGA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 573 LLHRDHTGR---------------NPLQLAAMSGYTETIE-LLHSVHSHL-LDQVDKDGNTALH--LATMENKPHaisvl 633
Cdd:cd22193 101 DVHAHAKGRffqpkyqgegfyfgeLPLSLAACTNQPDIVQyLLENEHQPAdIEAQDSRGNTVLHalVTVADNTKE----- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 634 msmGCKLVYNVLDMSAIDYAIYYkyPEAALamvtheeranEVMALRSDKHPcvtLALIASMPK--VFEAVQDKCITKANC 711
Cdd:cd22193 176 ---NTKFVTRMYDMILIRGAKLC--PTVEL----------EEIRNNDGLTP---LQLAAKMGKieILKYILQREIKEPEL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 712 KKDSKSF--------------------------------YTMVTHGRVELLAHPLSqKYLQMKWNSYGK---YFHLANLL 756
Cdd:cd22193 238 RHLSRKFtdwaygpvssslydlsnvdtceknsvleiivyNSKIDNRHEMLTLEPLN-TLLQDKWDKFAKymfFFSFCFYL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 757 IYSIFLVFVTIYSSLMMNNIELKAGDNKtmsqycnMGWEQLTmnlsqnpsvasqirldscEERINRTTAILFCAVVIVVY 836
Cdd:cd22193 317 FYMIIFTLVAYYRPREDEPPPPLAKTTK-------MDYMRLL------------------GEILVLLGGVYFFVKEIAYF 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 837 IL--LNSMRELIQIYQQKLHYILETVNLISWVLYISAlvmvtpafqpdgginTIHYSAASI-AVFLSWFRLLLFLQRFDQ 913
Cdd:cd22193 372 LLrrSDLQSSFSDSYFEILFFVQAVLVILSVVLYLFA---------------YKEYLACLVlALALGWANMLYYTRGFQS 436
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 914 VGIYVVMFLE-ILQTLIKVLMVFSILIIAFGLAFYILLSKIIDPQPNHLSFSNIPMSLLRTFSMM--LGELDFVgtyvnt 990
Cdd:cd22193 437 MGIYSVMIQKvILRDLLRFLFVYLLFLFGFAVALVSLIEKCSSDKKDCSSYGSFSDAVLELFKLTigMGDLEFQ------ 510
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442631147 991 yyrDQLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNA-QLKRLAMQVVLhTELERKLPhVWLQRVDKM 1066
Cdd:cd22193 511 ---ENSTYPAVFLILLLTYVILTFVLLLNMLIALMGETVNNVSKESkRIWKLQRAITI-LEFEKSFP-ECMRKAFRS 582
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
117-341 |
4.42e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 63.44 E-value: 4.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 117 RIALKDAKGRTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLsipvdtgvlnEKkqapvh 196
Cdd:PHA02874 116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLL----------EK------ 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 197 latelnkvkslrvmGQYRNVIDiqqggEHGRTALHLAAIYDHEECARILITEFDACPRKpCNNGYYPIHEAAKNASSkTM 276
Cdd:PHA02874 180 --------------GAYANVKD-----NNGESPLHNAAEYGDYACIKLLIDHGNHIMNK-CKNGFTPLHNAIIHNRS-AI 238
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631147 277 EVFFQwgeqrgctrEEMISFYDSEGNVPLHSAVH-GGDIKAVELCLKSGAKISTQQHDLSTPVHLA 341
Cdd:PHA02874 239 ELLIN---------NASINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
339-435 |
9.57e-10 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 56.66 E-value: 9.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 339 HLACAQGAIDIVKLMFEmQPMEKRlclsCTDVQKMTPLHCASMFDHPDIVSYLVaEGADINALDkEHRSPLLLAASRSGW 418
Cdd:pfam12796 2 HLAAKNGNLELVKLLLE-NGADAN----LQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKD-NGRTALHYAARSGHL 74
|
90
....*....|....*..
gi 442631147 419 KTVHLLIRLGACISVKD 435
Cdd:pfam12796 75 EIVKLLLEKGADINVKD 91
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
133-412 |
2.65e-09 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 61.19 E-value: 2.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 133 AARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLSIpVDTGV-LNEK---KQAPVHL----ATELNKV 204
Cdd:PHA03095 22 ASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIVRLL-LEAGAdVNAPercGFTPLHLylynATTLDVI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 205 KSLRVMGqyrnvIDIQQGGEHGRTALH--LAAIYDHEECARILItEFDACPRKPCNNGYYPIHEAAK--NASSKTMEVFF 280
Cdd:PHA03095 101 KLLIKAG-----ADVNAKDKVGRTPLHvyLSGFNINPKVIRLLL-RKGADVNALDLYGMTPLAVLLKsrNANVELLRLLI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 281 QWGEQrgctreemISFYDSEGNVPLHSavHGGDIKA----VELCLKSGAKISTQQHDLSTPVHLACAQG---AIDIVKLM 353
Cdd:PHA03095 175 DAGAD--------VYAVDDRFRSLLHH--HLQSFKPrariVRELIRAGCDPAATDMLGNTPLHSMATGSsckRSLVLPLL 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 442631147 354 femqpmEKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLA 412
Cdd:PHA03095 245 ------IAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLM 297
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
376-509 |
1.60e-08 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 53.20 E-value: 1.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 376 LHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRlgacisvkdaaarnvlhfvimnggrltdf 455
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE----------------------------- 51
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 442631147 456 aeqvancqtqaqlKLLLNEKDSmGCSPLHYASRDGHIRSLENLIRLGACINLKN 509
Cdd:pfam12796 52 -------------HADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
304-659 |
2.25e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 58.54 E-value: 2.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 304 PLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMFEMQPMEKRLCLSCTDVQKMTPLHCASMfd 383
Cdd:PHA02876 181 PIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDLSLLKAIRNEDLETSLL-- 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 384 hpdivsyLVAEGADINALDKEHRSPLLLAA-SRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGgrltdfaEQVANC 462
Cdd:PHA02876 259 -------LYDAGFSVNSIDDCKNTPLHHASqAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNG-------YDTENI 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 463 QTQAQLKLLLNEKDSMGCSPLHYASR-DGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDSekgsfii 541
Cdd:PHA02876 325 RTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDY------- 397
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 542 nesdGAGMTPLhisSQQghtrvvqlllnRGALLHRDHTGRNPlqlaamsgYTETIELLHSVHShlLDQVDKDGNTALHLA 621
Cdd:PHA02876 398 ----GADIEAL---SQK-----------IGTALHFALCGTNP--------YMSVKTLIDRGAN--VNSKNKDLSTPLHYA 449
|
330 340 350
....*....|....*....|....*....|....*....
gi 442631147 622 TMEN-KPHAISVLMSMGCklvynvlDMSAIDyaIYYKYP 659
Cdd:PHA02876 450 CKKNcKLDVIEMLLDNGA-------DVNAIN--IQNQYP 479
|
|
| PKD_channel |
pfam08016 |
Polycystin cation channel; This family contains the cation channel region from group II of ... |
821-1024 |
2.51e-08 |
|
Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.
Pssm-ID: 462341 [Multi-domain] Cd Length: 225 Bit Score: 55.75 E-value: 2.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 821 NRTTAILFCAVVIVVYILLNSMRELIQIYQQKLHYILETVNLISWVLYI-SALVMV------------------TP-AFQ 880
Cdd:pfam08016 5 NRSLFILLCEIVFVVFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVIlSVVLIVlniyrdfladrliksveaSPvTFI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 881 PDGGINTIHYSA---ASIAVFLSWFRLLLFLQRFDQvgiyVVMFLEILQTLIKVLM----VFSILIIAFGLAFYILLSKi 953
Cdd:pfam08016 85 DFDRVAQLDNLYriiLAFLVFLTWLKLFKVLRFNKT----MSLFTKTLSRAWKDLAgfalMFVIFFFAYAQFGYLLFGT- 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631147 954 idpqpNHLSFSNIPMSLLRTFSMMLGelDFVGTYVNTYYRdqlkvpMTSFLILSVFMILMPILLMNLLIGL 1024
Cdd:pfam08016 160 -----QAPNFSNFVKSILTLFRTILG--DFGYNEIFSGNR------VLGPLLFLTFVFLVIFILLNLFLAI 217
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
514-568 |
8.25e-08 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 49.97 E-value: 8.25e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 442631147 514 SPLHFAARYGRYNTVRQLLDSekgSFIINESDGAGMTPLHISSQQGHTRVVQLLL 568
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEK---GADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
239-431 |
9.14e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 55.77 E-value: 9.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 239 EECARILITEFDACpRKPCNNGYYPIHEAAKNASSKTMEVFFQwgeqrgctREEMISFYDSEGNVP----------LHSA 308
Cdd:PHA02875 5 ALCDAILFGELDIA-RRLLDIGINPNFEIYDGISPIKLAMKFR--------DSEAIKLLMKHGAIPdvkypdieseLHDA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 309 VHGGDIKAVELCLKSGAKISTQQH-DLSTPVHLACAQGAIDIVKLMFEMQPMEKrlcLSCTDvqKMTPLHCASMFDHPDI 387
Cdd:PHA02875 76 VEEGDVKAVEELLDLGKFADDVFYkDGMTPLHLATILKKLDIMKLLIARGADPD---IPNTD--KFSPLHLAVMMGDIKG 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 442631147 388 VSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACI 431
Cdd:PHA02875 151 IELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANI 194
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
492-668 |
9.59e-08 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 54.96 E-value: 9.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 492 IRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDsekGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRG 571
Cdd:COG0666 1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLL---ALLALALADALGALLLLAAALAGDLLVALLLLAAG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 572 ALLH-RDHTGRNPLQLAAMSGYTETIELLHSvHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMGCKLvyNVLD---M 647
Cdd:COG0666 78 ADINaKDDGGNTLLHAAARNGDLEIVKLLLE-AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADV--NAQDndgN 154
|
170 180
....*....|....*....|.
gi 442631147 648 SAIDYAIYYKYPEAALAMVTH 668
Cdd:COG0666 155 TPLHLAAANGNLEIVKLLLEA 175
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
135-436 |
1.08e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 55.83 E-value: 1.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 135 RNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLL--SIPVDTGVLNEKKqaPVHLATELNKVKslrvmgq 212
Cdd:PHA03100 12 IIKVKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLdnGADINSSTKNNST--PLHYLSNIKYNL------- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 213 yRNVIDIQQggehgrtalhlaaiydheecariLITEFDACPRKPCNNGYYPIHEAA--KNASSKTMEVFFqwgeQRGCTr 290
Cdd:PHA03100 83 -TDVKEIVK-----------------------LLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLL----DNGAN- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 291 eemISFYDSEGNVPLHSAVHGG--DIKAVELCLKSGAKIStqqhdlstpvhlacaqgAIDIVKLMfemqpMEKRLCLSCT 368
Cdd:PHA03100 134 ---VNIKNSDGENLLHLYLESNkiDLKILKLLIDKGVDIN-----------------AKNRVNYL-----LSYGVPINIK 188
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631147 369 DVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDA 436
Cdd:PHA03100 189 DVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
109-257 |
1.11e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 55.77 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 109 RLFMADNSRIALKDAKGRTAAHQAAARNRVNILRYIRDQN---GDFNAKDnaGNTPLHIAVESDAYDALDYLLSIPVDTG 185
Cdd:PHA02875 52 KLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGkfaDDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPD 129
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631147 186 VLNEKKQAPVHLATELNKVKSLRVMGQYRNVIDIQQGgeHGRTALHLAAIYDHEECARILI---TEFDACPRKPC 257
Cdd:PHA02875 130 IPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDC--CGCTPLIIAMAKGDIAICKMLLdsgANIDYFGKNGC 202
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
125-178 |
2.11e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 48.81 E-value: 2.11e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 442631147 125 GRTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLL 178
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
584-673 |
2.24e-07 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 49.73 E-value: 2.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 584 LQLAAMSGYTETIELLHSVHSHLlDQVDKDGNTALHLATMENKPHAISVLMSMGCKLVYNvLDMSAIDYAIYYKYPEAAL 663
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|
gi 442631147 664 AMVTHEERAN 673
Cdd:pfam12796 79 LLLEKGADIN 88
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
295-435 |
3.52e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 54.23 E-value: 3.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 295 SFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGaiDIVKLmfEMQPMEKRLCLSCTDVQKMT 374
Cdd:PHA02875 29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEG--DVKAV--EELLDLGKFADDVFYKDGMT 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631147 375 PLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKD 435
Cdd:PHA02875 105 PLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIED 165
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
126-399 |
6.30e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 53.07 E-value: 6.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 126 RTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLATELNKVK 205
Cdd:PHA02875 3 QVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 206 S---LRVMGQYRNVIDIQQggehGRTALHLAAIYDHEECARILItEFDACPRKPCNNGYYPIHEAAKNASSKTMEVFFqw 282
Cdd:PHA02875 83 AveeLLDLGKFADDVFYKD----GMTPLHLATILKKLDIMKLLI-ARGADPDIPNTDKFSPLHLAVMMGDIKGIELLI-- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 283 gEQRGCTREEmisfyDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTqqhdlstpvhlacaqgaidivklmfemqpMEKR 362
Cdd:PHA02875 156 -DHKACLDIE-----DCCGCTPLIIAMAKGDIAICKMLLDSGANIDY-----------------------------FGKN 200
|
250 260 270
....*....|....*....|....*....|....*....
gi 442631147 363 LCLS--CTDVQKmtplhcasmfDHPDIVSYLVAEGADIN 399
Cdd:PHA02875 201 GCVAalCYAIEN----------NKIDIVRLFIKRGADCN 229
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
230-330 |
1.01e-06 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 47.80 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 230 LHLAAIYDHEECARILItEFDACPRKPCNNGYYPIHEAAKNASSKTMEVFFqwgeqrgctrEEMISFYDSEGNVPLHSAV 309
Cdd:pfam12796 1 LHLAAKNGNLELVKLLL-ENGADANLQDKNGRTALHLAAKNGHLEIVKLLL----------EHADVNLKDNGRTALHYAA 69
|
90 100
....*....|....*....|.
gi 442631147 310 HGGDIKAVELCLKSGAKISTQ 330
Cdd:pfam12796 70 RSGHLEIVKLLLEKGADINVK 90
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
481-532 |
1.24e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 46.50 E-value: 1.24e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 442631147 481 SPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLL 532
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02736 |
PHA02736 |
Viral ankyrin protein; Provisional |
103-210 |
1.44e-06 |
|
Viral ankyrin protein; Provisional
Pssm-ID: 165103 [Multi-domain] Cd Length: 154 Bit Score: 49.10 E-value: 1.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 103 NLDDFKRLFMADNSRIALK-DAKGRTAAHQAAARNRV---NILRYIRDQNGDFNAKDNA-GNTPLHIAVESDAYDALDYL 177
Cdd:PHA02736 32 DLLAFKNAISDENRYLVLEyNRHGKQCVHIVSNPDKAdpqEKLKLLMEWGADINGKERVfGNTPLHIAVYTQNYELATWL 111
|
90 100 110
....*....|....*....|....*....|....
gi 442631147 178 LSIP-VDTGVLNEKKQAPVHLATELNKVKSLRVM 210
Cdd:PHA02736 112 CNQPgVNMEILNYAFKTPYYVACERHDAKMMNIL 145
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
335-392 |
2.14e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 45.73 E-value: 2.14e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 442631147 335 STPVHLACAQGAIDIVKLMFEmqpmeKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLV 392
Cdd:pfam13637 2 LTALHAAAASGHLELLRLLLE-----KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
373-425 |
3.26e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 45.34 E-value: 3.26e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 442631147 373 MTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLI 425
Cdd:pfam13637 2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
542-608 |
4.50e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 51.05 E-value: 4.50e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631147 542 NESDGAGMTPLHISSQQGHTRVVQLLLNRGA---LLHRDhtGRNPLQLAAMSGYTETIELL--HSVHSHLLD 608
Cdd:PTZ00322 109 NCRDYDGRTPLHIACANGHVQVVRVLLEFGAdptLLDKD--GKTPLELAEENGFREVVQLLsrHSQCHFELG 178
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
263-429 |
6.40e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 49.99 E-value: 6.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 263 PIHEAAKNASSKTMEVFFQWGEQRGCTreemisFYdSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLAC 342
Cdd:PHA02875 71 ELHDAVEEGDVKAVEELLDLGKFADDV------FY-KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 343 AQGAIDIVKLMfemqpMEKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGW-KTV 421
Cdd:PHA02875 144 MMGDIKGIELL-----IDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKiDIV 218
|
....*...
gi 442631147 422 HLLIRLGA 429
Cdd:PHA02875 219 RLFIKRGA 226
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
367-438 |
1.12e-05 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 49.51 E-value: 1.12e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631147 367 CTDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAA 438
Cdd:PTZ00322 110 CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGANA 181
|
|
| TRPV2 |
cd22197 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2; TRPV2 is closely ... |
899-1036 |
2.69e-05 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2; TRPV2 is closely related to TRPV1, sharing high sequence identity (>50%), but TRPV2 shows a higher temperature threshold and sensitivity for activation than TRPV1. TRPV2 can be stimulated by ligands or lipids, and is involved in osmosensation and mechanosensation. TRPV2 is expressed in both neuronal and non-neuronal tissues, and it has been implicated in diverse physiological and pathophysiological processes, including cardiac-structure maintenance, innate immunity, and cancer. TRPV2 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411981 [Multi-domain] Cd Length: 640 Bit Score: 48.31 E-value: 2.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 899 LSWFRLLLFLQRFDQVGIYVVMFLE-ILQTLIKVLMVFSILIIAFGLAFYILLSKIIDPQPN------------------ 959
Cdd:cd22197 437 LGWLNLLYYTRGFQHTGIYSVMIQKvILRDLLRFLLVYLVFLFGFAVALVSLSREAPSPKAPednnstvteqptvgqeee 516
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631147 960 HLSFSNIPMSLLR--TFSMMLGELDFvgtyvntyyRDQLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNA 1036
Cdd:cd22197 517 PAPYRSILDASLElfKFTIGMGELAF---------QEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNHVADNS 586
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
222-353 |
3.89e-05 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 47.94 E-value: 3.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 222 GGEHGRTALHLAAIYDHEECARILItefdacpRKPCN------NGYYPIHEAAKNASSKTMEVFFQWGEqrgctreemIS 295
Cdd:PLN03192 554 GDSKGRTPLHIAASKGYEDCVLVLL-------KHACNvhirdaNGNTALWNAISAKHHKIFRILYHFAS---------IS 617
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 442631147 296 FYDSEGNVpLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLM 353
Cdd:PLN03192 618 DPHAAGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLL 674
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
373-403 |
5.94e-05 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 41.12 E-value: 5.94e-05
10 20 30
....*....|....*....|....*....|..
gi 442631147 373 MTPLHCAS-MFDHPDIVSYLVAEGADINALDK 403
Cdd:pfam00023 3 NTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
|
|
| PHA02743 |
PHA02743 |
Viral ankyrin protein; Provisional |
93-218 |
8.89e-05 |
|
Viral ankyrin protein; Provisional
Pssm-ID: 222925 [Multi-domain] Cd Length: 166 Bit Score: 44.42 E-value: 8.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 93 FRILRAAESGNLDDFKRLFMADNSRIALKDAKGRTAAHQAAARNRVNILRYIR---DQNGDFNAKD-NAGNTPLHIAVES 168
Cdd:PHA02743 25 LRICRTGNIYELMEVAPFISGDGHLLHRYDHHGRQCTHMVAWYDRANAVMKIEllvNMGADINARElGTGNTLLHIAAST 104
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 442631147 169 DAYDALDYLLSIP-VDTGVLNEKKQAPVHLATELNKVKSLRVMGQYRNVID 218
Cdd:PHA02743 105 KNYELAEWLCRQLgVNLGAINYQHETAYHIAYKMRDRRMMEILRANGAVCD 155
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
535-587 |
1.10e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 41.18 E-value: 1.10e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 442631147 535 EKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLH-RDHTGRNPLQLA 587
Cdd:pfam13857 3 EHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNlKDEEGLTALDLA 56
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
304-353 |
1.22e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 40.72 E-value: 1.22e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 442631147 304 PLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLM 353
Cdd:pfam13637 4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
548-600 |
1.40e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 40.72 E-value: 1.40e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 442631147 548 GMTPLHISSQQGHTRVVQLLLNRGA-LLHRDHTGRNPLQLAAMSGYTETIELLH 600
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGAdINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
120-165 |
1.42e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 40.79 E-value: 1.42e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 442631147 120 LKDAKGRTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIA 165
Cdd:pfam13857 11 RLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
371-400 |
2.16e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 39.49 E-value: 2.16e-04
10 20 30
....*....|....*....|....*....|
gi 442631147 371 QKMTPLHCASMFDHPDIVSYLVAEGADINA 400
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
580-633 |
2.32e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 39.95 E-value: 2.32e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 442631147 580 GRNPLQLAAMSGYTETIELLHSvHSHLLDQVDKDGNTALHLATMENKPHAISVL 633
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLE-KGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| TRPV4 |
cd22195 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 4; TRPV4 is expressed ... |
851-1063 |
2.51e-04 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 4; TRPV4 is expressed broadly in neuronal and non-neuronal cells. It is activated by various stimuli, including hypo-osmolarity, warm temperature, and chemical ligands. TRPV4 acts in physiological functions such as osmoregulation and thermoregulation. It also has a role in mechanosensation in the vascular endothelium and urinary tract, and in cell barrier formation in vascular and epidermal tissues. Knockout mice studies suggested the functional importance of TRPV4 in the central nervous system, nociception, and bone formation. TRPV4 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411979 [Multi-domain] Cd Length: 733 Bit Score: 45.23 E-value: 2.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 851 QKLHYILETVNLISWVLYISAL-----VMVtpafqpdggintihysaasIAVFLSWFRLLLFLQRFDQVGIYVVMFLEIL 925
Cdd:cd22195 449 QLLYFIYSVLVIVTAALYLAGIeaylaVMV-------------------FALVLGWMNALYFTRGLKLTGTYSIMIQKIL 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 926 -QTLIKVLMVFSILIIAFGLAFYILLSKI------IDPQPN-----------HLSFSNIPMSLLRtFSMMLGELDFVgty 987
Cdd:cd22195 510 fKDLFRFLLVYLLFMIGYASALVSLLNPCptketcKEDSTNctvptypscrdSNTFSKFLLDLFK-LTIGMGDLEML--- 585
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631147 988 vntyyrDQLKVPMTSFLILSVFMILMPILLMNLLIGL---AVGDIEsvRRNAQLKRLAMQVVLhTELERKLPhVWLQRV 1063
Cdd:cd22195 586 ------NSAKYPAVFIILLVTYIILTFVLLLNMLIALmgeTVGQVS--KESKQIWKLQWATTI-LDIERSFP-VFLRKA 654
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
519-637 |
4.84e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 44.21 E-value: 4.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 519 AARYGRYNTVRQLLDSE-KGSFIINEsdgaGMTPLHISSQQGHTRVVQLLLNRGALLHRDHTG-RNPLQLAAMSGYTETI 596
Cdd:PHA02875 9 AILFGELDIARRLLDIGiNPNFEIYD----GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDiESELHDAVEEGDVKAV 84
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 442631147 597 ELLHSVHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMG 637
Cdd:PHA02875 85 EELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARG 125
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
368-586 |
5.35e-04 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 43.89 E-value: 5.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 368 TDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPL--LLAASRSGWKTVHLLIRLGACISvkdaaarnvlhfv 445
Cdd:PHA02946 68 TDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKIN------------- 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 446 imnggrltdfaeqvancqtqaqlklllNEKDSMGCSPLhYASRDGHIRSLENLIRLG--ACINLKNNNNESPLHFAARYG 523
Cdd:PHA02946 135 ---------------------------NSVDEEGCGPL-LACTDPSERVFKKIMSIGfeARIVDKFGKNHIHRHLMSDNP 186
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442631147 524 RYNTVRQLLdseKGSFIINESDGAGMTPLHI--SSQQGHTRVVQLLLNRGALLHRDHTGRNPLQL 586
Cdd:PHA02946 187 KASTISWMM---KLGISPSKPDHDGNTPLHIvcSKTVKNVDIINLLLPSTDVNKQNKFGDSPLTL 248
|
|
| TRPV1-4 |
cd22193 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ... |
366-501 |
5.78e-04 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411977 [Multi-domain] Cd Length: 607 Bit Score: 44.02 E-value: 5.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 366 SCTDV--QKMTPLHCASMFDHPDIVSYLVAEGADINAL--------DKEH------RSPLLLAASRSGWKTVHLLIR--- 426
Cdd:cd22193 68 EYTDEyyEGQTALHIAIERRQGDIVALLVENGADVHAHakgrffqpKYQGegfyfgELPLSLAACTNQPDIVQYLLEneh 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 427 LGACISVKDAAARNVLHFVIM---NGGRLTDFAEQV--------ANCQTQAQLKLLLNEKdsmGCSPLHYASRDGHIRSL 495
Cdd:cd22193 148 QPADIEAQDSRGNTVLHALVTvadNTKENTKFVTRMydmilirgAKLCPTVELEEIRNND---GLTPLQLAAKMGKIEIL 224
|
....*.
gi 442631147 496 ENLIRL 501
Cdd:cd22193 225 KYILQR 230
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
470-519 |
7.20e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.87 E-value: 7.20e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 442631147 470 LLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFA 519
Cdd:pfam13857 7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
226-279 |
7.27e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 38.79 E-value: 7.27e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 442631147 226 GRTALHLAAIYDHEECARILItEFDACPRKPCNNGYYPIHEAAKNASSKTMEVF 279
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
110-168 |
1.02e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 43.12 E-value: 1.02e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 442631147 110 LFMADNSRIALKDAKGRTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVES 168
Cdd:PHA03100 177 YLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILN 235
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
143-198 |
1.12e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.10 E-value: 1.12e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 442631147 143 YIRDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLA 198
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
109-358 |
2.06e-03 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 41.93 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 109 RLFMADNSRIALKDAKGRTAAH-QAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHI--AVESDAYDALDYLLSIPVDTG 185
Cdd:PHA03095 67 RLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGADVN 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 186 VLNEKKQAPVHLATELNK--VKSLRVM---GQY-RNVIDIqqggehGRTALHLAAIY--DHEECARILItEFDACPRKPC 257
Cdd:PHA03095 147 ALDLYGMTPLAVLLKSRNanVELLRLLidaGADvYAVDDR------FRSLLHHHLQSfkPRARIVRELI-RAGCDPAATD 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 258 NNGYYPIHEAAKNASsktmevffqwgeqrgCTREEMISFY---------DSEGNVPLHSAVHGGDIKAVELCLKSGAKIS 328
Cdd:PHA03095 220 MLGNTPLHSMATGSS---------------CKRSLVLPLLiagisinarNRYGQTPLHYAAVFNNPRACRRLIALGADIN 284
|
250 260 270
....*....|....*....|....*....|
gi 442631147 329 TQQHDLSTPVHLACAQGAIDIVKLMFEMQP 358
Cdd:PHA03095 285 AVSSDGNTPLSLMVRNNNGRAVRAALAKNP 314
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
373-400 |
2.58e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 36.47 E-value: 2.58e-03
10 20
....*....|....*....|....*...
gi 442631147 373 MTPLHCASMFDHPDIVSYLVAEGADINA 400
Cdd:pfam13606 3 NTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
16-179 |
3.41e-03 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 41.42 E-value: 3.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 16 LSPPDLMEAQPKLLPKPRSNSSGSTGRNSKYWIF---SMIIERSAgpkRI-------EIDGDDADTPLEAILPAE--PPA 83
Cdd:PTZ00322 1 MSFLVCSVASSAFAAQLFFGTEGSRKRRAKPISFermAAIQEEIA---RIdthlealEATENKDATPDHNLTTEEviDPV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 84 -------EVCLLrdspfrilraAESGNLDDFKRLFM--AD-NSRialkDAKGRTAAHQAAARNRVNILRYIRDQNGDFNA 153
Cdd:PTZ00322 78 vahmltvELCQL----------AASGDAVGARILLTggADpNCR----DYDGRTPLHIACANGHVQVVRVLLEFGADPTL 143
|
170 180
....*....|....*....|....*.
gi 442631147 154 KDNAGNTPLHIAVESDAYDALDYLLS 179
Cdd:PTZ00322 144 LDKDGKTPLELAEENGFREVVQLLSR 169
|
|
| PHA02741 |
PHA02741 |
hypothetical protein; Provisional |
98-213 |
3.45e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 165108 [Multi-domain] Cd Length: 169 Bit Score: 39.64 E-value: 3.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 98 AAESGNLDDFKRL--FMADNSRIAL---KDAKGRTAAHQAAARNR----VNILRYIRDQNGDFNAKDNA-GNTPLHIAVE 167
Cdd:PHA02741 28 AARCGCFDIIARFtpFIRGDCHAAAlnaTDDAGQMCIHIAAEKHEaqlaAEIIDHLIELGADINAQEMLeGDTALHLAAH 107
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 442631147 168 SDAYDALDYLLSIP-VDTGVLNEKKQAPVHLATELNKVKSLRVMGQY 213
Cdd:PHA02741 108 RRDHDLAEWLCCQPgIDLHFCNADNKSPFELAIDNEDVAMMQILREI 154
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
93-247 |
3.85e-03 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 41.39 E-value: 3.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 93 FRILRAAESGN---LDDFKRLFMADNsriaLKDAKGRTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIAVESD 169
Cdd:PLN03192 527 SNLLTVASTGNaalLEELLKAKLDPD----IGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAK 602
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 170 AYDALDYL-----LSIPVDTGVLnekkqapVHLATELNKVKSLRVMgqYRNVIDIQQGGEHGRTALHLAAIYDHEECARI 244
Cdd:PLN03192 603 HHKIFRILyhfasISDPHAAGDL-------LCTAAKRNDLTAMKEL--LKQGLNVDSEDHQGATALQVAMAEDHVDMVRL 673
|
...
gi 442631147 245 LIT 247
Cdd:PLN03192 674 LIM 676
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
479-510 |
3.96e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 36.11 E-value: 3.96e-03
10 20 30
....*....|....*....|....*....|...
gi 442631147 479 GCSPLHYAS-RDGHIRSLENLIRLGACINLKNN 510
Cdd:pfam00023 2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
|
|
| PHA02736 |
PHA02736 |
Viral ankyrin protein; Provisional |
440-572 |
4.55e-03 |
|
Viral ankyrin protein; Provisional
Pssm-ID: 165103 [Multi-domain] Cd Length: 154 Bit Score: 39.09 E-value: 4.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 440 NVLHFVIMNGG--RLTDFAEQVANCQtqaqlKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRL---GACINLKNN-NNE 513
Cdd:PHA02736 19 NILHYLCRNGGvtDLLAFKNAISDEN-----RYLVLEYNRHGKQCVHIVSNPDKADPQEKLKLLmewGADINGKERvFGN 93
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 514 SPLHFAARYGRYNTVRQLLDSEKGSF-IINEsdgAGMTPLHISSQQGHTRVVQLLLNRGA 572
Cdd:PHA02736 94 TPLHIAVYTQNYELATWLCNQPGVNMeILNY---AFKTPYYVACERHDAKMMNILRAKGA 150
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
98-155 |
5.39e-03 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 37.40 E-value: 5.39e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 442631147 98 AAESGNLDDFKRLfmADNSRIALKDaKGRTAAHQAAARNRVNILRYIRDQNGDFNAKD 155
Cdd:pfam12796 37 AAKNGHLEIVKLL--LEHADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
548-572 |
5.75e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 35.73 E-value: 5.75e-03
10 20
....*....|....*....|....*.
gi 442631147 548 GMTPLHI-SSQQGHTRVVQLLLNRGA 572
Cdd:pfam00023 2 GNTPLHLaAGRRGNLEIVKLLLSKGA 27
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
368-412 |
7.01e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 36.17 E-value: 7.01e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 442631147 368 TDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLA 412
Cdd:pfam13857 12 LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
495-646 |
8.84e-03 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 40.24 E-value: 8.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631147 495 LENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLdseKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRgALL 574
Cdd:PLN03192 541 LEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLL---KHACNVHIRDANGNTALWNAISAKHHKIFRILYHF-ASI 616
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442631147 575 HRDHTGRNPLQLAAMSGYTETI-ELLHsvHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMGCKLVYNVLD 646
Cdd:PLN03192 617 SDPHAAGDLLCTAAKRNDLTAMkELLK--QGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
|
|
|