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Conserved domains on  [gi|442631381|ref|NP_001261645|]
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uncharacterized protein Dmel_CG6761, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SANBR_BTB super family cl28778
SANT and BTB domain regulator of CSR, BTB domain; Class switch recombination (CSR) is the ...
 253-357 5.57e-29

SANT and BTB domain regulator of CSR, BTB domain; Class switch recombination (CSR) is the process by which B cells switch production from IgM/IgD to other immunoglobulin isotypes in the immune response process. This entry represents the BTB domain found at the N-terminal half of the protein SANT and BTB domain regulator of class switch recombination (SANBR, previously known as KIAA1841). This domain is responsible for the negative regulation of CSR.


The actual alignment was detected with superfamily member pfam11822:

Pssm-ID: 432102  Cd Length: 97  Bit Score: 111.03  E-value: 5.57e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631381  253 VVIHVCDEVKNTSKDFTCPQHLLVTKMGYFAD-----VTAGQRLEEMDISVHCDILIFDWLMKWIKHSAqsqdlpvptqs 327
Cdd:pfam11822   1 VEITVCDEAKNLKRDFRCPLDLLETEMRYFEPyisryISEAQRWPPVDIRVHCDVSIFDWLMNYVSGKA----------- 69

                          90       100       110
                  ....*....|....*....|....*....|
gi 442631381  328 tgPQLDGNNVVPILVSASFLQMEPLLLECL 357
Cdd:pfam11822  70 --PKLTPSNVVSILLSSNFLKMDQLVDNCL 97
 
Name Accession Description Interval E-value
SANBR_BTB pfam11822
SANT and BTB domain regulator of CSR, BTB domain; Class switch recombination (CSR) is the ...
 253-357 5.57e-29

SANT and BTB domain regulator of CSR, BTB domain; Class switch recombination (CSR) is the process by which B cells switch production from IgM/IgD to other immunoglobulin isotypes in the immune response process. This entry represents the BTB domain found at the N-terminal half of the protein SANT and BTB domain regulator of class switch recombination (SANBR, previously known as KIAA1841). This domain is responsible for the negative regulation of CSR.


Pssm-ID: 432102  Cd Length: 97  Bit Score: 111.03  E-value: 5.57e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631381  253 VVIHVCDEVKNTSKDFTCPQHLLVTKMGYFAD-----VTAGQRLEEMDISVHCDILIFDWLMKWIKHSAqsqdlpvptqs 327
Cdd:pfam11822   1 VEITVCDEAKNLKRDFRCPLDLLETEMRYFEPyisryISEAQRWPPVDIRVHCDVSIFDWLMNYVSGKA----------- 69

                          90       100       110
                  ....*....|....*....|....*....|
gi 442631381  328 tgPQLDGNNVVPILVSASFLQMEPLLLECL 357
Cdd:pfam11822  70 --PKLTPSNVVSILLSSNFLKMDQLVDNCL 97
 
Name Accession Description Interval E-value
SANBR_BTB pfam11822
SANT and BTB domain regulator of CSR, BTB domain; Class switch recombination (CSR) is the ...
 253-357 5.57e-29

SANT and BTB domain regulator of CSR, BTB domain; Class switch recombination (CSR) is the process by which B cells switch production from IgM/IgD to other immunoglobulin isotypes in the immune response process. This entry represents the BTB domain found at the N-terminal half of the protein SANT and BTB domain regulator of class switch recombination (SANBR, previously known as KIAA1841). This domain is responsible for the negative regulation of CSR.


Pssm-ID: 432102  Cd Length: 97  Bit Score: 111.03  E-value: 5.57e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631381  253 VVIHVCDEVKNTSKDFTCPQHLLVTKMGYFAD-----VTAGQRLEEMDISVHCDILIFDWLMKWIKHSAqsqdlpvptqs 327
Cdd:pfam11822   1 VEITVCDEAKNLKRDFRCPLDLLETEMRYFEPyisryISEAQRWPPVDIRVHCDVSIFDWLMNYVSGKA----------- 69

                          90       100       110
                  ....*....|....*....|....*....|
gi 442631381  328 tgPQLDGNNVVPILVSASFLQMEPLLLECL 357
Cdd:pfam11822  70 --PKLTPSNVVSILLSSNFLKMDQLVDNCL 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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