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Conserved domains on  [gi|442631750|ref|NP_001261723|]
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dynein, axonemal, intermediate chain 2, isoform C [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 212-469 3.41e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 3.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 212 KVPCVCLEYnqkDPTSLVSGMYNGQVAAWDTRHGKLpvmisEREVC-HRDPVNSVLWnnSKSGTEFFSGGSDGQVLWWDT 290
Cdd:cd00200   11 GVTCVAFSP---DGKLLATGSGDGTIKVWDLETGEL-----LRTLKgHTGPVRDVAA--SADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 291 RKlTEPLDRLLMDpvksddqdlsRSYGISVleyettiptRFMAgtEMGMLFSCNRKGK-----TPTEKIQIRMMCHLGPV 365
Cdd:cd00200   81 ET-GECVRTLTGH----------TSYVSSV---------AFSP--DGRILSSSSRDKTikvwdVETGKCLTTLRGHTDWV 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 366 YAITRNPafVKNFLTVGDW--CARIWseDCRESSIIWT-KSSSSMLTDGAWSYTKvSQFFITRMDGVLDTWDLLQQQneP 442
Cdd:cd00200  139 NSVAFSP--DGTFVASSSQdgTIKLW--DLRTGKCVATlTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGK--C 211

                        250       260
                 ....*....|....*....|....*..
gi 442631750 443 VLTVKVCDEPLYCVRTNENGKFVSCGS 469
Cdd:cd00200  212 LGTLRGHENGVNSVAFSPDGYLLASGS 238
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 212-469 3.41e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 3.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 212 KVPCVCLEYnqkDPTSLVSGMYNGQVAAWDTRHGKLpvmisEREVC-HRDPVNSVLWnnSKSGTEFFSGGSDGQVLWWDT 290
Cdd:cd00200   11 GVTCVAFSP---DGKLLATGSGDGTIKVWDLETGEL-----LRTLKgHTGPVRDVAA--SADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 291 RKlTEPLDRLLMDpvksddqdlsRSYGISVleyettiptRFMAgtEMGMLFSCNRKGK-----TPTEKIQIRMMCHLGPV 365
Cdd:cd00200   81 ET-GECVRTLTGH----------TSYVSSV---------AFSP--DGRILSSSSRDKTikvwdVETGKCLTTLRGHTDWV 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 366 YAITRNPafVKNFLTVGDW--CARIWseDCRESSIIWT-KSSSSMLTDGAWSYTKvSQFFITRMDGVLDTWDLLQQQneP 442
Cdd:cd00200  139 NSVAFSP--DGTFVASSSQdgTIKLW--DLRTGKCVATlTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGK--C 211

                        250       260
                 ....*....|....*....|....*..
gi 442631750 443 VLTVKVCDEPLYCVRTNENGKFVSCGS 469
Cdd:cd00200  212 LGTLRGHENGVNSVAFSPDGYLLASGS 238
WD40 COG2319
WD40 repeat [General function prediction only];
160-291 1.63e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 160 PVKHLSWSPDGGIkMAVSHCDMRFQgdksnqkcnsyIWEVENPnEPFLTLEPKVPCV-CLEYNQkDPTSLVSGMYNGQVA 238
Cdd:COG2319  206 AVRSVAFSPDGKL-LASGSADGTVR-----------LWDLATG-KLLRTLTGHSGSVrSVAFSP-DGRLLASGSADGTVR 271

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 442631750 239 AWDTRHGKLPVMISErevcHRDPVNSVLWnnSKSGTEFFSGGSDGQVLWWDTR 291
Cdd:COG2319  272 LWDLATGELLRTLTG----HSGGVNSVAF--SPDGKLLASGSDDGTVRLWDLA 318
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 257-289 1.85e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.85e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442631750   257 CHRDPVNSVLWnnSKSGTEFFSGGSDGQVLWWD 289
Cdd:smart00320  10 GHTGPVTSVAF--SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
257-289 7.48e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 7.48e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 442631750  257 CHRDPVNSVLWnnSKSGTEFFSGGSDGQVLWWD 289
Cdd:pfam00400   9 GHTGSVTSLAF--SPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 212-469 3.41e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 3.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 212 KVPCVCLEYnqkDPTSLVSGMYNGQVAAWDTRHGKLpvmisEREVC-HRDPVNSVLWnnSKSGTEFFSGGSDGQVLWWDT 290
Cdd:cd00200   11 GVTCVAFSP---DGKLLATGSGDGTIKVWDLETGEL-----LRTLKgHTGPVRDVAA--SADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 291 RKlTEPLDRLLMDpvksddqdlsRSYGISVleyettiptRFMAgtEMGMLFSCNRKGK-----TPTEKIQIRMMCHLGPV 365
Cdd:cd00200   81 ET-GECVRTLTGH----------TSYVSSV---------AFSP--DGRILSSSSRDKTikvwdVETGKCLTTLRGHTDWV 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 366 YAITRNPafVKNFLTVGDW--CARIWseDCRESSIIWT-KSSSSMLTDGAWSYTKvSQFFITRMDGVLDTWDLLQQQneP 442
Cdd:cd00200  139 NSVAFSP--DGTFVASSSQdgTIKLW--DLRTGKCVATlTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGK--C 211

                        250       260
                 ....*....|....*....|....*..
gi 442631750 443 VLTVKVCDEPLYCVRTNENGKFVSCGS 469
Cdd:cd00200  212 LGTLRGHENGVNSVAFSPDGYLLASGS 238
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 160-292 1.26e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 160 PVKHLSWSPDGGIkMAVSHCDMRFQgdksnqkcnsyIWEVENpNEPFLTLEPK---VPCVCLeynQKDPTSLVSGMYNGQ 236
Cdd:cd00200   95 YVSSVAFSPDGRI-LSSSSRDKTIK-----------VWDVET-GKCLTTLRGHtdwVNSVAF---SPDGTFVASSSQDGT 158

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631750 237 VAAWDTRHGKLPVMISErevcHRDPVNSVLWnnSKSGTEFFSGGSDGQVLWWDTRK 292
Cdd:cd00200  159 IKLWDLRTGKCVATLTG----HTGEVNSVAF--SPDGEKLLSSSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
160-291 1.63e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 160 PVKHLSWSPDGGIkMAVSHCDMRFQgdksnqkcnsyIWEVENPnEPFLTLEPKVPCV-CLEYNQkDPTSLVSGMYNGQVA 238
Cdd:COG2319  206 AVRSVAFSPDGKL-LASGSADGTVR-----------LWDLATG-KLLRTLTGHSGSVrSVAFSP-DGRLLASGSADGTVR 271

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 442631750 239 AWDTRHGKLPVMISErevcHRDPVNSVLWnnSKSGTEFFSGGSDGQVLWWDTR 291
Cdd:COG2319  272 LWDLATGELLRTLTG----HSGGVNSVAF--SPDGKLLASGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 160-292 8.71e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 8.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 160 PVKHLSWSPDGGIkmaVSHCDmrfqGDKSnqkcnSYIWEVENpNEPFLTL---EPKVPCVCLEynqKDPTSLVSGMYNGQ 236
Cdd:cd00200  137 WVNSVAFSPDGTF---VASSS----QDGT-----IKLWDLRT-GKCVATLtghTGEVNSVAFS---PDGEKLLSSSSDGT 200

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631750 237 VAAWDTRHGKLPVMIsereVCHRDPVNSVLWnnSKSGTEFFSGGSDGQVLWWDTRK 292
Cdd:cd00200  201 IKLWDLSTGKCLGTL----RGHENGVNSVAF--SPDGYLLASGSEDGTIRVWDLRT 250
WD40 COG2319
WD40 repeat [General function prediction only];
160-291 2.54e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 2.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 160 PVKHLSWSPDGgiKMAVSHCDmrfqgDKSNQkcnsyIWEVENPnEPFLTLEPKVPCV-CLEYNQkDPTSLVSGMYNGQVA 238
Cdd:COG2319  290 GVNSVAFSPDG--KLLASGSD-----DGTVR-----LWDLATG-KLLRTLTGHTGAVrSVAFSP-DGKTLASGSDDGTVR 355

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 442631750 239 AWDTRHGKLPVMISErevcHRDPVNSVLWnnSKSGTEFFSGGSDGQVLWWDTR 291
Cdd:COG2319  356 LWDLATGELLRTLTG----HTGAVTSVAF--SPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
160-291 5.58e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 5.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 160 PVKHLSWSPDGgiKMAVSHCDmrfqgDKSnqkcnSYIWEVENPNEPFLTLEPKVPCVCLEYNQkDPTSLVSGMYNGQVAA 239
Cdd:COG2319  122 AVRSVAFSPDG--KTLASGSA-----DGT-----VRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRL 188

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 442631750 240 WDTRHGKLPVMISErevcHRDPVNSVLWnnSKSGTEFFSGGSDGQVLWWDTR 291
Cdd:COG2319  189 WDLATGKLLRTLTG----HTGAVRSVAF--SPDGKLLASGSADGTVRLWDLA 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 160-289 7.32e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 7.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 160 PVKHLSWSPDGGiKMAVSHCDMrfqgdksnqkcNSYIWEVENPnEPFLTLEPK-VPCVCLEYNQkDPTSLVSGMYNGQVA 238
Cdd:cd00200  179 EVNSVAFSPDGE-KLLSSSSDG-----------TIKLWDLSTG-KCLGTLRGHeNGVNSVAFSP-DGYLLASGSEDGTIR 244

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442631750 239 AWDTRHGKLPVMISErevcHRDPVNSVLWnnSKSGTEFFSGGSDGQVLWWD 289
Cdd:cd00200  245 VWDLRTGECVQTLSG----HTNSVTSLAW--SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
160-298 1.02e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 160 PVKHLSWSPDGGIKMAVShcdmrfqGDKSNQkcnsyIWEVENPNEPFLTLEPKVPCVCLEYNQkDPTSLVSGMYNGQVAA 239
Cdd:COG2319   80 AVLSVAFSPDGRLLASAS-------ADGTVR-----LWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRL 146

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442631750 240 WDTRHGKLPVMISErevcHRDPVNSVLWnnSKSGTEFFSGGSDGQVLWWD--TRKLTEPLD 298
Cdd:COG2319  147 WDLATGKLLRTLTG----HSGAVTSVAF--SPDGKLLASGSDDGTVRLWDlaTGKLLRTLT 201
WD40 COG2319
WD40 repeat [General function prediction only];
160-295 1.72e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631750 160 PVKHLSWSPDGGIkMAVSHCDMRFQgdksnqkcnsyIWEVENPNEPFLTLEPKVPCVCLEYNqKDPTSLVSGMYNGQVAA 239
Cdd:COG2319  248 SVRSVAFSPDGRL-LASGSADGTVR-----------LWDLATGELLRTLTGHSGGVNSVAFS-PDGKLLASGSDDGTVRL 314

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631750 240 WDTRHGKLPVMISErevcHRDPVNSVLWnnSKSGTEFFSGGSDGQVLWWDTRKLTE 295
Cdd:COG2319  315 WDLATGKLLRTLTG----HTGAVRSVAF--SPDGKTLASGSDDGTVRLWDLATGEL 364
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 257-289 1.85e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.85e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442631750   257 CHRDPVNSVLWnnSKSGTEFFSGGSDGQVLWWD 289
Cdd:smart00320  10 GHTGPVTSVAF--SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
257-289 7.48e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 7.48e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 442631750  257 CHRDPVNSVLWnnSKSGTEFFSGGSDGQVLWWD 289
Cdd:pfam00400   9 GHTGSVTSLAF--SPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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