NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|442633688|ref|NP_001262110|]
View 

presenilin, isoform D [Drosophila melanogaster]

Protein Classification

presenilin( domain architecture ID 10471201)

presenilin is the catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Presenilin pfam01080
Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It ...
98-517 0e+00

Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.


:

Pssm-ID: 460052  Cd Length: 394  Bit Score: 558.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688   98 KYGAQHVIKLFVPVSLCMLVVVATINSISFYNS--TDVY-LLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIV 174
Cdd:pfam01080   1 KYGAKQVIKLFVPVSLCMLLVVATIRSISFYSSqvNDEAsLVYTPFHEESDSTGTKLLNSLLNALIFIGVIVVMTFLLVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688  175 LYKKRCYRIIHGWLILSSFMLLFIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAAL 254
Cdd:pfam01080  81 LYKYRCYKVIHGWLILSSLLLLFLFSGLYLGELLSAYNIPMDYITFAFILWNFGVVGMIAIFWKGPLLLQQAYLISISAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688  255 MALVFIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQqsqatasss 334
Cdd:pfam01080 161 MALVFIKYLPEWTTWVLLVVISIWDLFAVLCPKGPLRLLVETAQERNEPIFPALIYSATMVWLYAGSQVAM--------- 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688  335 psssnsttttratQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEAEaAGFTQEWSANLSERVARRQIEVQSTQSG 414
Cdd:pfam01080 232 -------------SDEGTSARTVKQTISNYSKNEASESEFSQSSRSSRTAN-PDSGLTWPTSPPELSSERSEEAQSPLSS 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688  415 NAQRSNEyrtvtaPDQNHPDGQEERGIKLGLGDFIFYSVLVGKASSYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPA 494
Cdd:pfam01080 298 STEESSE------PEENRNKLNDSRGVKLGLGDFIFYSVLVGKAAMYGDWNTVIACFVAILIGLCLTLLLLAIFKKALPA 371
                         410       420
                  ....*....|....*....|...
gi 442633688  495 LPISITFGLIFCFATSAVVKPFM 517
Cdd:pfam01080 372 LPISIAFGLIFYFSTRFLVEPFV 394
 
Name Accession Description Interval E-value
Presenilin pfam01080
Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It ...
98-517 0e+00

Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.


Pssm-ID: 460052  Cd Length: 394  Bit Score: 558.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688   98 KYGAQHVIKLFVPVSLCMLVVVATINSISFYNS--TDVY-LLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIV 174
Cdd:pfam01080   1 KYGAKQVIKLFVPVSLCMLLVVATIRSISFYSSqvNDEAsLVYTPFHEESDSTGTKLLNSLLNALIFIGVIVVMTFLLVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688  175 LYKKRCYRIIHGWLILSSFMLLFIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAAL 254
Cdd:pfam01080  81 LYKYRCYKVIHGWLILSSLLLLFLFSGLYLGELLSAYNIPMDYITFAFILWNFGVVGMIAIFWKGPLLLQQAYLISISAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688  255 MALVFIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQqsqatasss 334
Cdd:pfam01080 161 MALVFIKYLPEWTTWVLLVVISIWDLFAVLCPKGPLRLLVETAQERNEPIFPALIYSATMVWLYAGSQVAM--------- 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688  335 psssnsttttratQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEAEaAGFTQEWSANLSERVARRQIEVQSTQSG 414
Cdd:pfam01080 232 -------------SDEGTSARTVKQTISNYSKNEASESEFSQSSRSSRTAN-PDSGLTWPTSPPELSSERSEEAQSPLSS 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688  415 NAQRSNEyrtvtaPDQNHPDGQEERGIKLGLGDFIFYSVLVGKASSYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPA 494
Cdd:pfam01080 298 STEESSE------PEENRNKLNDSRGVKLGLGDFIFYSVLVGKAAMYGDWNTVIACFVAILIGLCLTLLLLAIFKKALPA 371
                         410       420
                  ....*....|....*....|...
gi 442633688  495 LPISITFGLIFCFATSAVVKPFM 517
Cdd:pfam01080 372 LPISIAFGLIFYFSTRFLVEPFV 394
PSN smart00730
Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic ...
152-513 5.97e-62

Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease. Distant homologues, present in eukaryotes and archaea, also contain conserved aspartic acid residues which are predicted to contribute to catalysis. At least one member of this family has been shown to possess signal peptide peptidase activity.


Pssm-ID: 214793  Cd Length: 249  Bit Score: 203.64  E-value: 5.97e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688   152 WSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFTYLYLEELLRaynipMDYPTALLIMWNFGVVG 231
Cdd:smart00730   1 EYSLLNSLVAIVFPIVATFVLVLLYKFFKYLVIVLVIYFSSLGVLFLYSLLYPLEVFR-----VDYPTLLILLLNFAVVG 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688   232 MMSIHWQgpLRLQQGYLIFVAALMALVFIKYLP-EWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQI--FPAL 308
Cdd:smart00730  76 FWCIHRK--GAWIQQDLIGISLCMAILFILRLPsEWTAWILLGALFIYDIFAVFGTPGPLRVMVEVATGRDEPIkvFPAL 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688   309 IYSSTVVyalvntvtpqqsqatassspsssnsttttratqnslaspeaaaasgqrtgnshprqnqrddgsvlateaeaag 388
Cdd:smart00730 154 LYVPRLV------------------------------------------------------------------------- 160
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688   389 ftqewsanlservarrqievqstqsgnaqrsneyrtvtapdQNHPDGQEERGIKLGLGDFIFYSVLVGKASSYG-----D 463
Cdd:smart00730 161 -----------------------------------------VSFEDDEEERFSMLGLGDIVFPGILVASAARFDvsvrsD 199
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 442633688   464 WTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLIFCFATSAVV 513
Cdd:smart00730 200 SNYFLACFVAYGIGLILTLVLLALFKKAQPALPYLVPFTLVFYLLTALLR 249
MdoB COG1368
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ...
133-325 1.19e-04

Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440979 [Multi-domain]  Cd Length: 576  Bit Score: 44.64  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688 133 VYLLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRcYRIIHGWLILSSFMLLFIF--TYLYLEELLRA 210
Cdd:COG1368   13 LVFLLFNFDLSLGEILQAFLYGLRFILYLLLLLLLLLLLLLPLLFRR-PKLRWIYLLLVLLLLLLLLvaDILYYRFFGDR 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688 211 YNIpmdypTALLIMWNFGVVGMMSIHWqGPLRLQQGYLIFVAALMALVFI--KYLPEWTAWAVLAAISIWDLIAVLSPR- 287
Cdd:COG1368   92 LNF-----SDLDYLGDTGEVLGSLLSS-YDLLLLLDLLLLLLLLLLLYRLlkKLRKSLPWRKRLALLLLLLALLLLGIRl 165
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 442633688 288 -GPLRILVETAQERNEQIFP-ALIYSSTVVYALVNTVTPQ 325
Cdd:COG1368  166 gEDRPLNLSDAFSRNNFVNElGLNGPYSFYDALRNNKAPA 205
 
Name Accession Description Interval E-value
Presenilin pfam01080
Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It ...
98-517 0e+00

Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.


Pssm-ID: 460052  Cd Length: 394  Bit Score: 558.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688   98 KYGAQHVIKLFVPVSLCMLVVVATINSISFYNS--TDVY-LLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIV 174
Cdd:pfam01080   1 KYGAKQVIKLFVPVSLCMLLVVATIRSISFYSSqvNDEAsLVYTPFHEESDSTGTKLLNSLLNALIFIGVIVVMTFLLVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688  175 LYKKRCYRIIHGWLILSSFMLLFIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAAL 254
Cdd:pfam01080  81 LYKYRCYKVIHGWLILSSLLLLFLFSGLYLGELLSAYNIPMDYITFAFILWNFGVVGMIAIFWKGPLLLQQAYLISISAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688  255 MALVFIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQqsqatasss 334
Cdd:pfam01080 161 MALVFIKYLPEWTTWVLLVVISIWDLFAVLCPKGPLRLLVETAQERNEPIFPALIYSATMVWLYAGSQVAM--------- 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688  335 psssnsttttratQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEAEaAGFTQEWSANLSERVARRQIEVQSTQSG 414
Cdd:pfam01080 232 -------------SDEGTSARTVKQTISNYSKNEASESEFSQSSRSSRTAN-PDSGLTWPTSPPELSSERSEEAQSPLSS 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688  415 NAQRSNEyrtvtaPDQNHPDGQEERGIKLGLGDFIFYSVLVGKASSYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPA 494
Cdd:pfam01080 298 STEESSE------PEENRNKLNDSRGVKLGLGDFIFYSVLVGKAAMYGDWNTVIACFVAILIGLCLTLLLLAIFKKALPA 371
                         410       420
                  ....*....|....*....|...
gi 442633688  495 LPISITFGLIFCFATSAVVKPFM 517
Cdd:pfam01080 372 LPISIAFGLIFYFSTRFLVEPFV 394
PSN smart00730
Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic ...
152-513 5.97e-62

Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease. Distant homologues, present in eukaryotes and archaea, also contain conserved aspartic acid residues which are predicted to contribute to catalysis. At least one member of this family has been shown to possess signal peptide peptidase activity.


Pssm-ID: 214793  Cd Length: 249  Bit Score: 203.64  E-value: 5.97e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688   152 WSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFTYLYLEELLRaynipMDYPTALLIMWNFGVVG 231
Cdd:smart00730   1 EYSLLNSLVAIVFPIVATFVLVLLYKFFKYLVIVLVIYFSSLGVLFLYSLLYPLEVFR-----VDYPTLLILLLNFAVVG 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688   232 MMSIHWQgpLRLQQGYLIFVAALMALVFIKYLP-EWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQI--FPAL 308
Cdd:smart00730  76 FWCIHRK--GAWIQQDLIGISLCMAILFILRLPsEWTAWILLGALFIYDIFAVFGTPGPLRVMVEVATGRDEPIkvFPAL 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688   309 IYSSTVVyalvntvtpqqsqatassspsssnsttttratqnslaspeaaaasgqrtgnshprqnqrddgsvlateaeaag 388
Cdd:smart00730 154 LYVPRLV------------------------------------------------------------------------- 160
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688   389 ftqewsanlservarrqievqstqsgnaqrsneyrtvtapdQNHPDGQEERGIKLGLGDFIFYSVLVGKASSYG-----D 463
Cdd:smart00730 161 -----------------------------------------VSFEDDEEERFSMLGLGDIVFPGILVASAARFDvsvrsD 199
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 442633688   464 WTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLIFCFATSAVV 513
Cdd:smart00730 200 SNYFLACFVAYGIGLILTLVLLALFKKAQPALPYLVPFTLVFYLLTALLR 249
MdoB COG1368
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ...
133-325 1.19e-04

Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440979 [Multi-domain]  Cd Length: 576  Bit Score: 44.64  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688 133 VYLLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRcYRIIHGWLILSSFMLLFIF--TYLYLEELLRA 210
Cdd:COG1368   13 LVFLLFNFDLSLGEILQAFLYGLRFILYLLLLLLLLLLLLLPLLFRR-PKLRWIYLLLVLLLLLLLLvaDILYYRFFGDR 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633688 211 YNIpmdypTALLIMWNFGVVGMMSIHWqGPLRLQQGYLIFVAALMALVFI--KYLPEWTAWAVLAAISIWDLIAVLSPR- 287
Cdd:COG1368   92 LNF-----SDLDYLGDTGEVLGSLLSS-YDLLLLLDLLLLLLLLLLLYRLlkKLRKSLPWRKRLALLLLLLALLLLGIRl 165
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 442633688 288 -GPLRILVETAQERNEQIFP-ALIYSSTVVYALVNTVTPQ 325
Cdd:COG1368  166 gEDRPLNLSDAFSRNNFVNElGLNGPYSFYDALRNNKAPA 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH