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Conserved domains on  [gi|442633744|ref|NP_001262120|]
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uncharacterized protein Dmel_CG34260 [Drosophila melanogaster]

Protein Classification

DUF1091 domain-containing protein( domain architecture ID 10534441)

DUF1091 domain-containing protein similar to Drosophila melanogaster chemosensory protein A 84a

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1091 pfam06477
Protein of unknown function (DUF1091); This is a family of uncharacterized proteins. Based on ...
 73-154 3.80e-11

Protein of unknown function (DUF1091); This is a family of uncharacterized proteins. Based on its distant similarity to pfam02221 and conserved pattern of cysteine residues it is possible that these domains are also lipid binding.


:

Pssm-ID: 461928  Cd Length: 83  Bit Score: 56.55  E-value: 3.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633744   73 TFDLIKKD--KSRMNIADIKIDGCKYLGSMYqNNIVGKLFKRLKSVSNLPDSCPVSKGkLYEIRNYTFISDEFPPGAPQA 150
Cdd:pfam06477   2 NISLFKRRenGYKPFLYNVTVDFCKFLKNPN-NPLFKIFYKNLKKFSNLNHTCPYPKG-NYYLRNFVLDEDLLPSFLPEG 79


                  ....
gi 442633744  151 KWQV 154
Cdd:pfam06477  80 DYKI 83
 
Name Accession Description Interval E-value
DUF1091 pfam06477
Protein of unknown function (DUF1091); This is a family of uncharacterized proteins. Based on ...
 73-154 3.80e-11

Protein of unknown function (DUF1091); This is a family of uncharacterized proteins. Based on its distant similarity to pfam02221 and conserved pattern of cysteine residues it is possible that these domains are also lipid binding.


Pssm-ID: 461928  Cd Length: 83  Bit Score: 56.55  E-value: 3.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633744   73 TFDLIKKD--KSRMNIADIKIDGCKYLGSMYqNNIVGKLFKRLKSVSNLPDSCPVSKGkLYEIRNYTFISDEFPPGAPQA 150
Cdd:pfam06477   2 NISLFKRRenGYKPFLYNVTVDFCKFLKNPN-NPLFKIFYKNLKKFSNLNHTCPYPKG-NYYLRNFVLDEDLLPSFLPEG 79


                  ....
gi 442633744  151 KWQV 154
Cdd:pfam06477  80 DYKI 83
DM8 smart00697
Repeats found in several Drosophila proteins;
88-151 5.59e-09

Repeats found in several Drosophila proteins;


Pssm-ID: 214778  Cd Length: 93  Bit Score: 50.84  E-value: 5.59e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442633744    88 DIKIDGCKYLGSMYQNNIVGKLFKRLKSVSNLPDSCPVSKGKlYEIRNYTFISDEFPPGAPQAK 151
Cdd:smart00697   7 NVTTDVCKLLKSRNQIPLIRIILKSLLKFSNFNDTCPLPKGH-YYLRNFRLDENLLPSFLPDGD 69
 
Name Accession Description Interval E-value
DUF1091 pfam06477
Protein of unknown function (DUF1091); This is a family of uncharacterized proteins. Based on ...
 73-154 3.80e-11

Protein of unknown function (DUF1091); This is a family of uncharacterized proteins. Based on its distant similarity to pfam02221 and conserved pattern of cysteine residues it is possible that these domains are also lipid binding.


Pssm-ID: 461928  Cd Length: 83  Bit Score: 56.55  E-value: 3.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633744   73 TFDLIKKD--KSRMNIADIKIDGCKYLGSMYqNNIVGKLFKRLKSVSNLPDSCPVSKGkLYEIRNYTFISDEFPPGAPQA 150
Cdd:pfam06477   2 NISLFKRRenGYKPFLYNVTVDFCKFLKNPN-NPLFKIFYKNLKKFSNLNHTCPYPKG-NYYLRNFVLDEDLLPSFLPEG 79


                  ....
gi 442633744  151 KWQV 154
Cdd:pfam06477  80 DYKI 83
DM8 smart00697
Repeats found in several Drosophila proteins;
88-151 5.59e-09

Repeats found in several Drosophila proteins;


Pssm-ID: 214778  Cd Length: 93  Bit Score: 50.84  E-value: 5.59e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442633744    88 DIKIDGCKYLGSMYQNNIVGKLFKRLKSVSNLPDSCPVSKGKlYEIRNYTFISDEFPPGAPQAK 151
Cdd:smart00697   7 NVTTDVCKLLKSRNQIPLIRIILKSLLKFSNFNDTCPLPKGH-YYLRNFRLDENLLPSFLPDGD 69
ML smart00737
Domain involved in innate immunity and lipid metabolism; ML (MD-2-related lipid-recognition) ...
 45-158 2.94e-03

Domain involved in innate immunity and lipid metabolism; ML (MD-2-related lipid-recognition) is a novel domain identified in MD-1, MD-2, GM2A, Npc2 and multiple proteins of unknown function in plants, animals and fungi. These single-domain proteins were predicted to form a beta-rich fold containing multiple strands, and to mediate diverse biological functions through interacting with specific lipids.


Pssm-ID: 214796  Cd Length: 119  Bit Score: 35.81  E-value: 2.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633744    45 CLLVRQRTAVVAVKFSLNQTIEHfdvlATFDL-IKKDKSRMNIADIKIDGCKYLGSmyqnnivgklfkrlksvsnlpdSC 123
Cdd:smart00737  20 CPPVRGKTLTISISFTLNEDISK----LKVVVhVKIGGIEVPIPGETYDLCKLTGS----------------------KC 73

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 442633744   124 PVSKGKLYeirNYTFiSDEFPPGAPQAKWQVRLKL 158
Cdd:smart00737  74 PIEKGETV---NYTN-SLTVPGIFPPGKYTVKWEL 104
E1_DerP2_DerF2 pfam02221
ML domain; ML domain - MD-2-related lipid recognition domain. This family consists of proteins ...
 42-154 9.54e-03

ML domain; ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2. It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.


Pssm-ID: 460498  Cd Length: 133  Bit Score: 34.65  E-value: 9.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633744   42 SLECLLVRQRTAVVAVKFSLNQTIEhfDVLATfDLIKKdksrmnIADIKI--------DGCKYLGSmyqnnivgklfkrl 113
Cdd:pfam02221  23 SPPCPLVRGQNLTISASGTTSDEIS--QGLKV-DVEVR------LGGITLpfplpetrDLCDELEV-------------- 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 442633744  114 ksvsNLPDSCPVSKGKLYEIRNYTFISDEFPPGAPQAKWQV 154
Cdd:pfam02221  80 ----GSGLSCPIKAGEYVTYTLTLPLPSEYPPGKYTVEAEL 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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