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Conserved domains on  [gi|442634029|ref|NP_001262185|]
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uncharacterized protein Dmel_CG43980, isoform C [Drosophila melanogaster]

Protein Classification

ankyrin repeat and BTB/POZ domain-containing protein( domain architecture ID 15064773)

ANK (ankyrin repeat) and BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein

Gene Ontology:  GO:0005515
PubMed:  17176038|17120193|15544948

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1343-1460 1.09e-64

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 214.83  E-value: 1.09e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1343 RIDPKFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSsTPTVQINDIRYHIFQLVMQFLYCGGCSSL 1422
Cdd:cd18297     1 RIDPHYVNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQ-TPVIEIPDIRYDIFQLMMQYLYTGGVESL 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 442634029 1423 DVAHGDVLELMAAASFFQLEGLLRYTEARCSEMVDVDN 1460
Cdd:cd18297    80 DVAQDDALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
HFD_ABTB2-like cd22913
histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) ...
 668-763 1.01e-46

histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, which has implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). This subfamily also includes BTB/POZ domain-containing protein 11 (BTBD11), also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11. It is a BTB-domain-containing Kelch-like protein with unknown function.


:

Pssm-ID: 467038  Cd Length: 105  Bit Score: 162.85  E-value: 1.01e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  668 VPGESALKQSKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEIALQCNG---------TTAAALDQS 738
Cdd:cd22913     1 MSSGDQLRRSKSARCGLTFSVGRFHRWMVDSRLAKRIHEHAAVYLTACMENLLEEIFLRALAslvpkgeleLTVEALEYG 80

                          90       100
                  ....*....|....*....|....*
gi 442634029  739 IASSGDVWGLLQPFAHLNAGRIASG 763
Cdd:cd22913    81 INNDAELWGLLQPYEHLICGRNASG 105
BACK_ABTB2_like cd18491
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 1456-1527 6.09e-33

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins involved in a range of functions from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications in Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homologue (PTEN). This subfamily also includes BTB/POZ domain-containing protein 11 (BTBD11), whose function is unclear.


:

Pssm-ID: 350566  Cd Length: 72  Bit Score: 122.39  E-value: 6.09e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442634029 1456 VDVDNVVAMYIHAKVYNANRLLEFCQCFLLQNMVALLTYDDSVKRLLFAKKIPNHDVLAGLLQTLQNRLKAR 1527
Cdd:cd18491     1 LDLDNVVAIYKHAKLYNAPELLAYCEGYFLQNMVQLLLENDSFRKLLFGKKLHGHDVLQGLQATLTQRIQSR 72
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
983-1173 2.11e-18

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 87.70  E-value: 2.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  983 LLLTGRAELLAQAAQLLPPTTRYDTQNSAGLTALMIASIRNDEVALHALLDAGCDPNVevppagsagypaiqPDTQHWTA 1062
Cdd:COG0666    58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNA--------------RDKDGETP 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1063 LSFAASRANYVALRILLERGGKVEggARSSEEKctlTPLQLAAGTGNLEIVALLLAHGANAFLSTQQKDSlcfagsaqkg 1142
Cdd:COG0666   124 LHLAAYNGNLEIVKLLLEAGADVN--AQDNDGN---TPLHLAAANGNLEIVKLLLEAGADVNARDNDGET---------- 188

                         170       180       190
                  ....*....|....*....|....*....|.
gi 442634029 1143 cfcAISVAAAHGHRSCLRKLLTHPVSPGTRD 1173
Cdd:COG0666   189 ---PLHLAAENGHLEIVKLLLEAGADVNAKD 216
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 270-428 2.80e-09

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 62.09  E-value: 2.80e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029   270 PNFVQHQAPSQVTGLPPV-------PPPQMQSPHQVQS--QLPPSQTPLSSQKGLAVAMATPAPRVFKELAQQPNKGMP- 339
Cdd:pfam03154  286 PSHMQHPVPPQPFPLTPQssqsqvpPGPSPAAPGQSQQriHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPq 365

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029   340 ------HKMVASSSSCSGGQANSSCKMP---SPGTASKALIPQRAVAGPARLTVQSTPVKSQPPQLSGsLSQSQVSPnrp 410
Cdd:pfam03154  366 lpnpqsHKHPPHLSGPSPFQMNSNLPPPpalKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPV-LTQSQSLP--- 441

                          170
                   ....*....|....*...
gi 442634029   411 ilgiPTTAANPTPPRIHQ 428
Cdd:pfam03154  442 ----PPAASHPPTSGLHQ 455
 
Name Accession Description Interval E-value
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1343-1460 1.09e-64

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 214.83  E-value: 1.09e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1343 RIDPKFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSsTPTVQINDIRYHIFQLVMQFLYCGGCSSL 1422
Cdd:cd18297     1 RIDPHYVNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQ-TPVIEIPDIRYDIFQLMMQYLYTGGVESL 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 442634029 1423 DVAHGDVLELMAAASFFQLEGLLRYTEARCSEMVDVDN 1460
Cdd:cd18297    80 DVAQDDALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
HFD_ABTB2-like cd22913
histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) ...
 668-763 1.01e-46

histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, which has implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). This subfamily also includes BTB/POZ domain-containing protein 11 (BTBD11), also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11. It is a BTB-domain-containing Kelch-like protein with unknown function.


Pssm-ID: 467038  Cd Length: 105  Bit Score: 162.85  E-value: 1.01e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  668 VPGESALKQSKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEIALQCNG---------TTAAALDQS 738
Cdd:cd22913     1 MSSGDQLRRSKSARCGLTFSVGRFHRWMVDSRLAKRIHEHAAVYLTACMENLLEEIFLRALAslvpkgeleLTVEALEYG 80

                          90       100
                  ....*....|....*....|....*
gi 442634029  739 IASSGDVWGLLQPFAHLNAGRIASG 763
Cdd:cd22913    81 INNDAELWGLLQPYEHLICGRNASG 105
BACK_ABTB2_like cd18491
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 1456-1527 6.09e-33

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins involved in a range of functions from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications in Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homologue (PTEN). This subfamily also includes BTB/POZ domain-containing protein 11 (BTBD11), whose function is unclear.


Pssm-ID: 350566  Cd Length: 72  Bit Score: 122.39  E-value: 6.09e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442634029 1456 VDVDNVVAMYIHAKVYNANRLLEFCQCFLLQNMVALLTYDDSVKRLLFAKKIPNHDVLAGLLQTLQNRLKAR 1527
Cdd:cd18491     1 LDLDNVVAIYKHAKLYNAPELLAYCEGYFLQNMVQLLLENDSFRKLLFGKKLHGHDVLQGLQATLTQRIQSR 72
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 1350-1446 1.28e-21

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 91.16  E-value: 1.28e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  1350 NNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGGCSSLDvahgDV 1429
Cdd:pfam00651    6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESE-SSVSEITLDDVSPEDFEALLEFMYTGKLISEE----NV 80

                           90
                   ....*....|....*..
gi 442634029  1430 LELMAAASFFQLEGLLR 1446
Cdd:pfam00651   81 DDLLAAADKLQIPSLVD 97
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 1356-1449 5.07e-20

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 86.21  E-value: 5.07e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029   1356 DVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELMAA 1435
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKE-SDKSEIYLDDVSPEDFRALLNFLYTG---KLDLPEENVEELLEL 76

                            90
                    ....*....|....
gi 442634029   1436 ASFFQLEGLLRYTE 1449
Cdd:smart00225   77 ADYLQIPGLVELCE 90
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
983-1173 2.11e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 87.70  E-value: 2.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  983 LLLTGRAELLAQAAQLLPPTTRYDTQNSAGLTALMIASIRNDEVALHALLDAGCDPNVevppagsagypaiqPDTQHWTA 1062
Cdd:COG0666    58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNA--------------RDKDGETP 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1063 LSFAASRANYVALRILLERGGKVEggARSSEEKctlTPLQLAAGTGNLEIVALLLAHGANAFLSTQQKDSlcfagsaqkg 1142
Cdd:COG0666   124 LHLAAYNGNLEIVKLLLEAGADVN--AQDNDGN---TPLHLAAANGNLEIVKLLLEAGADVNARDNDGET---------- 188

                         170       180       190
                  ....*....|....*....|....*....|.
gi 442634029 1143 cfcAISVAAAHGHRSCLRKLLTHPVSPGTRD 1173
Cdd:COG0666   189 ---PLHLAAENGHLEIVKLLLEAGADVNAKD 216
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1016-1122 2.66e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.29  E-value: 2.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  1016 LMIASIRNDEVALHALLDAGCDPNVEvppagsagypaiqpDTQHWTALSFAASRANYVALRILLERggkveggARSSEEK 1095
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQ--------------DKNGRTALHLAAKNGHLEIVKLLLEH-------ADVNLKD 59

                           90       100
                   ....*....|....*....|....*..
gi 442634029  1096 CTLTPLQLAAGTGNLEIVALLLAHGAN 1122
Cdd:pfam12796   60 NGRTALHYAARSGHLEIVKLLLEKGAD 86
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 270-428 2.80e-09

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 62.09  E-value: 2.80e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029   270 PNFVQHQAPSQVTGLPPV-------PPPQMQSPHQVQS--QLPPSQTPLSSQKGLAVAMATPAPRVFKELAQQPNKGMP- 339
Cdd:pfam03154  286 PSHMQHPVPPQPFPLTPQssqsqvpPGPSPAAPGQSQQriHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPq 365

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029   340 ------HKMVASSSSCSGGQANSSCKMP---SPGTASKALIPQRAVAGPARLTVQSTPVKSQPPQLSGsLSQSQVSPnrp 410
Cdd:pfam03154  366 lpnpqsHKHPPHLSGPSPFQMNSNLPPPpalKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPV-LTQSQSLP--- 441

                          170
                   ....*....|....*...
gi 442634029   411 ilgiPTTAANPTPPRIHQ 428
Cdd:pfam03154  442 ----PPAASHPPTSGLHQ 455
PHA03098 PHA03098
kelch-like protein; Provisional
 1357-1496 1.43e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 55.93  E-value: 1.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1357 VTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGsstpTVQINdIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELMAAA 1436
Cdd:PHA03098   14 IIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKEN----EINLN-IDYDSFNEVIKYIYTG---KINITSNNVKDILSIA 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1437 SFFQLEGLLRYTEARCSEMVDVDNVVAMYIHAKVYNANRLLEFCQCFLLQNMVALLTYDD 1496
Cdd:PHA03098   86 NYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPD 145
PTZ00017 PTZ00017
histone H2A; Provisional
 677-723 1.28e-05

histone H2A; Provisional


Pssm-ID: 185399  Cd Length: 134  Bit Score: 46.28  E-value: 1.28e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 442634029  677 SKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEI 723
Cdd:PTZ00017   19 SRSAKAGLQFPVGRVHRYLKKGRYAKRVGAGAPVYLAAVLEYLTAEV 65
H2A smart00414
Histone 2A;
677-723 1.83e-05

Histone 2A;


Pssm-ID: 197711  Cd Length: 106  Bit Score: 45.02  E-value: 1.83e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 442634029    677 SKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEI 723
Cdd:smart00414    1 SRSARAGLQFPVGRIHRLLRKGTYAKRVGAGAPVYLAAVLEYLTAEV 47
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1099-1178 3.11e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 48.54  E-value: 3.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  1099 TPLQLAAGTGNLEIVALLLAHGA--------NAFLSTQQKDSLCFAGSaqkgcfcAISVAAAHGHRSCLRKLLTHPVSPG 1170
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERGAsvparacgDFFVKSQGVDSFYHGES-------PLNAAACLGSPSIVALLSEDPADIL 202


                   ....*...
gi 442634029  1171 TRDVLSLE 1178
Cdd:TIGR00870  203 TADSLGNT 210
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1002-1133 4.84e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 47.95  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1002 TTRYDTQNSAGLTALMIASIRNDEVALHA---LLDAGCDPNVEVPPAGSagyPAIQPDTQHWTALSFAASRANYVALRIL 1078
Cdd:cd21882    16 TDSAYQRGATGKTCLHKAALNLNDGVNEAimlLLEAAPDSGNPKELVNA---PCTDEFYQGQTALHIAIENRNLNLVRLL 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442634029 1079 LERGGKVEG---GARSSEEKCTLT-----PLQLAAGTGNLEIVALLLAHGANAfLSTQQKDSL 1133
Cdd:cd21882    93 VENGADVSAratGRFFRKSPGNLFyfgelPLSLAACTNQEEIVRLLLENGAQP-AALEAQDSL 154
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 964-1122 7.50e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.56  E-value: 7.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  964 IGEDTSELGRRATIGVAfkllLTGRAELLAQaaqLLPPTTRYDTQNSAGLTALMIASIRNDEVALHALLDAGCDPNVEVP 1043
Cdd:PLN03192  517 GGEHDDPNMASNLLTVA----STGNAALLEE---LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDA 589

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1044 PAGSAGYPAIQPDTQ-------HWTALS----------FAASRANYVALRILLERGGKVEggarsSEEKCTLTPLQLAAG 1106
Cdd:PLN03192  590 NGNTALWNAISAKHHkifrilyHFASISdphaagdllcTAAKRNDLTAMKELLKQGLNVD-----SEDHQGATALQVAMA 664

                         170
                  ....*....|....*.
gi 442634029 1107 TGNLEIVALLLAHGAN 1122
Cdd:PLN03192  665 EDHVDMVRLLIMNGAD 680
PHA03247 PHA03247
large tegument protein UL36; Provisional
 255-424 1.76e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  255 QEWRRAAKRPTgnlppnfvqhqaPSQVTGLPPVPPPQMQ---SPHQVQSQLPPSQTPLSSQKGLAVAMATPAPRVFKELA 331
Cdd:PHA03247 2681 QRPRRRAARPT------------VGSLTSLADPPPPPPTpepAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGP 2748

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  332 QQPNKGMPhkmVASSSSCSGGQANSSCKMPSPGTASKALIPQRAVAGPARLTVQSTPVKSQPPQLSGSLSQSQVSPNRPI 411
Cdd:PHA03247 2749 ATPGGPAR---PARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825

                         170
                  ....*....|....
gi 442634029  412 LGI-PTTAANPTPP 424
Cdd:PHA03247 2826 GPLpPPTSAQPTAP 2839
HTA1 COG5262
Histone H2A [Chromatin structure and dynamics];
676-723 5.60e-04

Histone H2A [Chromatin structure and dynamics];


Pssm-ID: 227587 [Multi-domain]  Cd Length: 132  Bit Score: 41.77  E-value: 5.60e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 442634029  676 QSKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEI 723
Cdd:COG5262    17 QSRSAKAGLIFPVGRVKRLLKKGNYRMRIGAGAPVYLAAVLEYLAAEI 64
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1099-1122 8.24e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 8.24e-03
                            10        20
                    ....*....|....*....|....
gi 442634029   1099 TPLQLAAGTGNLEIVALLLAHGAN 1122
Cdd:smart00248    4 TPLHLAAENGNLEVVKLLLDKGAD 27
 
Name Accession Description Interval E-value
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1343-1460 1.09e-64

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 214.83  E-value: 1.09e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1343 RIDPKFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSsTPTVQINDIRYHIFQLVMQFLYCGGCSSL 1422
Cdd:cd18297     1 RIDPHYVNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQ-TPVIEIPDIRYDIFQLMMQYLYTGGVESL 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 442634029 1423 DVAHGDVLELMAAASFFQLEGLLRYTEARCSEMVDVDN 1460
Cdd:cd18297    80 DVAQDDALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
HFD_ABTB2-like cd22913
histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) ...
 668-763 1.01e-46

histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, which has implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). This subfamily also includes BTB/POZ domain-containing protein 11 (BTBD11), also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11. It is a BTB-domain-containing Kelch-like protein with unknown function.


Pssm-ID: 467038  Cd Length: 105  Bit Score: 162.85  E-value: 1.01e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  668 VPGESALKQSKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEIALQCNG---------TTAAALDQS 738
Cdd:cd22913     1 MSSGDQLRRSKSARCGLTFSVGRFHRWMVDSRLAKRIHEHAAVYLTACMENLLEEIFLRALAslvpkgeleLTVEALEYG 80

                          90       100
                  ....*....|....*....|....*
gi 442634029  739 IASSGDVWGLLQPFAHLNAGRIASG 763
Cdd:cd22913    81 INNDAELWGLLQPYEHLICGRNASG 105
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1326-1462 8.30e-45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 158.47  E-value: 8.30e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1326 TLPPVKEQPPmqpvqgSRIDPKFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLS-EGSSTPTVQINDIRY 1404
Cdd:cd18350     2 SIPEIRKTLP------ARLDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNKSEqESQGSKTIEISDIKY 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 442634029 1405 HIFQLVMQFLYCGGCSSLDVAHGDVLELMAAASFFQLEGLLRYTEARCSEMVDVDNVV 1462
Cdd:cd18350    76 HIFQMLMQYLYYGGTESMEIPIADVLELLSAASLFQLDALQRHCEILCSQTINLENAV 133
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1340-1462 9.16e-44

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 155.52  E-value: 9.16e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1340 QGSRIDPKFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTptVQINDIRYHIFQLVMQFLYCGGC 1419
Cdd:cd18351    10 QTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTC--IEISYVKYHIFQLVMQYLYCGGT 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 442634029 1420 SSLDVAHGDVLELMAAASFFQLEGLLRYTEARCSEMVDVDNVV 1462
Cdd:cd18351    88 ESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTENCV 130
BACK_ABTB2_like cd18491
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 1456-1527 6.09e-33

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins involved in a range of functions from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications in Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homologue (PTEN). This subfamily also includes BTB/POZ domain-containing protein 11 (BTBD11), whose function is unclear.


Pssm-ID: 350566  Cd Length: 72  Bit Score: 122.39  E-value: 6.09e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442634029 1456 VDVDNVVAMYIHAKVYNANRLLEFCQCFLLQNMVALLTYDDSVKRLLFAKKIPNHDVLAGLLQTLQNRLKAR 1527
Cdd:cd18491     1 LDLDNVVAIYKHAKLYNAPELLAYCEGYFLQNMVQLLLENDSFRKLLFGKKLHGHDVLQGLQATLTQRIQSR 72
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1439 1.06e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 93.39  E-value: 1.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELM 1433
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKE-SSSSEIELDDVSPEAFEALLDYIYTG---ELELSEENVEELL 76


                  ....*.
gi 442634029 1434 AAASFF 1439
Cdd:cd18186    77 AAADKL 82
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 1347-1461 1.28e-22

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 94.47  E-value: 1.28e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1347 KFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYCGgcsSLDVAH 1426
Cdd:cd18352     6 QYVNNATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEAR-DIEIPNIRWEVFELMMRFIYTG---SVDITN 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 442634029 1427 GDVLELMAAASFFQLEGLLRYTEARCSEMVDVDNV 1461
Cdd:cd18352    82 DIAKDLLRAADQYLLEGLKRLCEYTIAQDLTLENI 116
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 1350-1446 1.28e-21

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 91.16  E-value: 1.28e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  1350 NNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGGCSSLDvahgDV 1429
Cdd:pfam00651    6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESE-SSVSEITLDDVSPEDFEALLEFMYTGKLISEE----NV 80

                           90
                   ....*....|....*..
gi 442634029  1430 LELMAAASFFQLEGLLR 1446
Cdd:pfam00651   81 DDLLAAADKLQIPSLVD 97
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 1356-1449 5.07e-20

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 86.21  E-value: 5.07e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029   1356 DVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELMAA 1435
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKE-SDKSEIYLDDVSPEDFRALLNFLYTG---KLDLPEENVEELLEL 76

                            90
                    ....*....|....
gi 442634029   1436 ASFFQLEGLLRYTE 1449
Cdd:smart00225   77 ADYLQIPGLVELCE 90
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
983-1173 2.11e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 87.70  E-value: 2.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  983 LLLTGRAELLAQAAQLLPPTTRYDTQNSAGLTALMIASIRNDEVALHALLDAGCDPNVevppagsagypaiqPDTQHWTA 1062
Cdd:COG0666    58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNA--------------RDKDGETP 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1063 LSFAASRANYVALRILLERGGKVEggARSSEEKctlTPLQLAAGTGNLEIVALLLAHGANAFLSTQQKDSlcfagsaqkg 1142
Cdd:COG0666   124 LHLAAYNGNLEIVKLLLEAGADVN--AQDNDGN---TPLHLAAANGNLEIVKLLLEAGADVNARDNDGET---------- 188

                         170       180       190
                  ....*....|....*....|....*....|.
gi 442634029 1143 cfcAISVAAAHGHRSCLRKLLTHPVSPGTRD 1173
Cdd:COG0666   189 ---PLHLAAENGHLEIVKLLLEAGADVNAKD 216
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1347-1450 4.19e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 81.52  E-value: 4.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1347 KFVNNPELSDVTFRV--EGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVQINDIRYHIFQLVMQFLYCgGCSSLDV 1424
Cdd:cd18294     7 SLINNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVLSDIEPEVFRAVLEFIYT-NCVTLSN 85

                          90       100
                  ....*....|....*....|....*.
gi 442634029 1425 AhgDVLELMAAASFFQLEGLLRYTEA 1450
Cdd:cd18294    86 H--TVIEVLAAAVEYGLDELRKLCER 109
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 1347-1449 1.63e-16

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 76.51  E-value: 1.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1347 KFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGGCSSLDVah 1426
Cdd:cd18300     2 LFLNKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRE-SSAKEVELPGVSKETFLALLEYLYTDQAPILED-- 78

                          90       100
                  ....*....|....*....|...
gi 442634029 1427 GDVLELMAAASFFQLEGLLRYTE 1449
Cdd:cd18300    79 GDCVGLIVLANRLCLPRLVALCE 101
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1353-1441 2.90e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 70.90  E-value: 2.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1353 ELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLEL 1432
Cdd:cd18256    19 EFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSE-SSKDVVQIHGVEPDIFHILLDFIYTG---VVEVTVSNVQEL 94


                  ....*....
gi 442634029 1433 MAAASFFQL 1441
Cdd:cd18256    95 LVAADMLQL 103
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 1354-1443 5.56e-14

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 68.73  E-value: 5.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSegSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELM 1433
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPP--DEHPVIILPDVPYSELKALLDFIYTG---EVNVSQEQLESLL 75

                          90
                  ....*....|
gi 442634029 1434 AAASFFQLEG 1443
Cdd:cd18315    76 KLAELLQIKG 85
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 1349-1445 3.02e-12

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 64.29  E-value: 3.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1349 VNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGD 1428
Cdd:cd18314     1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLK-EVTLEDVEPEIFETVLKYMYTG---QVTLSEEN 76

                          90
                  ....*....|....*..
gi 442634029 1429 VLELMAAASFFQLEGLL 1445
Cdd:cd18314    77 VLDLLMLASKYQVPDLE 93
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1348-1442 9.09e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 63.46  E-value: 9.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1348 FVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHG 1427
Cdd:cd18238     9 FYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAE-SKQDSITIKDIDEEAVELLVDFAYTG---KLTLTVD 84

                          90
                  ....*....|....*
gi 442634029 1428 DVLELMAAASFFQLE 1442
Cdd:cd18238    85 NVQSLLYAASLLQVE 99
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 1357-1439 1.00e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 61.91  E-value: 1.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1357 VTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYCGGcssLDVAHGDVLELMAAA 1436
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQA-EINLRDISPEDFRALLEFLYGGK---RDLDASNLLELLEAA 76


                  ...
gi 442634029 1437 SFF 1439
Cdd:cd01165    77 NFL 79
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1351-1460 1.81e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 62.89  E-value: 1.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1351 NPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDVL 1430
Cdd:cd18237    18 QKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTE-SKSSEVELKDAEPDIIELLVEFAY---TARISVNSNNVQ 93

                          90       100       110
                  ....*....|....*....|....*....|
gi 442634029 1431 ELMAAASFFQLEGLLRYTEARCSEMVDVDN 1460
Cdd:cd18237    94 SLLDAANQYQIEPVKKMCVDFLKEQLDASN 123
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1350-1446 2.40e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 61.89  E-value: 2.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1350 NNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDV 1429
Cdd:cd18298     8 NDPRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKN-VIEIDQYSYPVYYAFLRYLYTD---QVDLPPEDA 83

                          90
                  ....*....|....*..
gi 442634029 1430 LELMAAASFFQLEGLLR 1446
Cdd:cd18298    84 IGLLDLANSYCEERLKK 100
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1349-1442 2.40e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 62.25  E-value: 2.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1349 VNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGGCSSLDVAHGD 1428
Cdd:cd18287    17 FLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRE-SQQSEIELKDTNAEAFKALLKYIYTGRLTLTDLKEDV 95

                          90
                  ....*....|....*..
gi 442634029 1429 VLELMAAA---SFFQLE 1442
Cdd:cd18287    96 LLDVLGLAhqyGFEELE 112
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1353-1451 2.49e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 62.35  E-value: 2.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1353 ELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYC------GGCSSLDVAH 1426
Cdd:cd18280    13 EGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEG-EIVIEDVEPPVFKALLHFIYKdelpddVEPAGSDSSS 91

                          90       100
                  ....*....|....*....|....*...
gi 442634029 1427 GDVL---ELMAAASFFQLEGLLRYTEAR 1451
Cdd:cd18280    92 LDTTmaqHLLAAADRYALERLRLLCESR 119
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1016-1122 2.66e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.29  E-value: 2.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  1016 LMIASIRNDEVALHALLDAGCDPNVEvppagsagypaiqpDTQHWTALSFAASRANYVALRILLERggkveggARSSEEK 1095
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQ--------------DKNGRTALHLAAKNGHLEIVKLLLEH-------ADVNLKD 59

                           90       100
                   ....*....|....*....|....*..
gi 442634029  1096 CTLTPLQLAAGTGNLEIVALLLAHGAN 1122
Cdd:pfam12796   60 NGRTALHYAARSGHLEIVKLLLEKGAD 86
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1443 3.23e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 62.07  E-value: 3.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELM 1433
Cdd:cd18242    21 LCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSE-KGKSEVELQGLTASTMEILLDFVYTE---TVHVTVENVQELL 96

                          90
                  ....*....|
gi 442634029 1434 AAASFFQLEG 1443
Cdd:cd18242    97 PAACLLQLKG 106
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1347-1417 3.61e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 61.53  E-value: 3.61e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442634029 1347 KFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVQIN--DIRYHIFQLVMQFLYCG 1417
Cdd:cd18292    10 QLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVedPECAAVFEKFLRYLYTG 82
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1351-1460 6.56e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 61.17  E-value: 6.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1351 NPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGGCSSLDVAHGDvl 1430
Cdd:cd18343    18 NSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEE-SKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADN-- 94

                          90       100       110
                  ....*....|....*....|....*....|.
gi 442634029 1431 eLMAAASFFQLEGL-LRYTEARCSEMvDVDN 1460
Cdd:cd18343    95 -LLAAADKYALERLkVMCEEALCNNL-SVEN 123
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1351-1461 8.95e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 60.63  E-value: 8.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1351 NPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGGCSSLDVAHGDvl 1430
Cdd:cd18345    15 RSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEE-RKQNRVEITDVDHEVMREMLRFIYTGKAPNLDKMADD-- 91

                          90       100       110
                  ....*....|....*....|....*....|..
gi 442634029 1431 eLMAAASFFQLEGL-LRYTEARCSEMVdVDNV 1461
Cdd:cd18345    92 -LLAAADKYALERLkVMCEEALCSNLS-VENV 121
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1351-1442 1.34e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 60.47  E-value: 1.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1351 NPELSDVTFRVEGKI----FYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYcggCSSLDVAH 1426
Cdd:cd18248    18 SQQLCDVTLKVKYQDpkeeFMAHKVVLASSSPYFKAMFTSGLRE-CGMEVVPIEGVHPCVMSRLIEFAY---TASISVGE 93

                          90
                  ....*....|....*.
gi 442634029 1427 GDVLELMAAASFFQLE 1442
Cdd:cd18248    94 KCVLHVLPGAVMYQMD 109
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1350-1462 1.47e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 60.03  E-value: 1.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1350 NNPELSDVTFRVEGKIFYGHKIVLVTASPRFqsmlssKLSEGSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDV 1429
Cdd:cd18303    14 DKELYSDITIKLADKSIPAHKFVLAARSEKW------SNENLASTNELDLSDISYEVVLALLRWLYTD---ELDLTLDDE 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 442634029 1430 --LELMAAASFFQLEGLLRYTEARCSEMVDVDNVV 1462
Cdd:cd18303    85 flLELMKAAKRFQLTDLVERCERALMSSVNVDNCI 119
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1351-1460 1.95e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 59.85  E-value: 1.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1351 NPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPtVQINDIRYHIFQLVMQFLYCGGCSSLDVAHGDVL 1430
Cdd:cd18279    15 NSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNR-VEINDVDPEVFKEMMRFIYTGKAPNLDKMADDLL 93

                          90       100       110
                  ....*....|....*....|....*....|.
gi 442634029 1431 elmAAASFFQLEGL-LRYTEARCSEMvDVDN 1460
Cdd:cd18279    94 ---AAADKYALERLkVMCEDALCSNL-SVEN 120
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 1356-1422 3.41e-10

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 58.45  E-value: 3.41e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1356 DVTFRVEGKIFYGHKIVLVTASPRFQSM-LSSKLSEGSST--PTVQINDIRYHIFQLVMQFLYCGGCSSL 1422
Cdd:cd18301    20 DVVFQVGGKTFPAHKFILASRSDYFRKLfLSSLLTSEDAVgcDVVHIEKVPPEIFEQLLQFIYTDTCDLL 89
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 1356-1446 4.00e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 58.85  E-value: 4.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1356 DVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSST----PTVQINDIRYHIFQLVMQFLYCGGCsslDVAHGDVLE 1431
Cdd:cd18296    19 DVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsiPVVTLHDVSPEVFAIVLYYIYTDDT---DLPPENAYD 95

                          90
                  ....*....|....*
gi 442634029 1432 LMAAASFFQLEGLLR 1446
Cdd:cd18296    96 VLYVADMYLLPGLKR 110
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1441 5.51e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 58.45  E-value: 5.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELM 1433
Cdd:cd18247    19 LCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVE-SKQDEITMQGIEPSALEALINFAYSG---RIAIDTSNVQSLL 94


                  ....*...
gi 442634029 1434 AAASFFQL 1441
Cdd:cd18247    95 VGASFLQL 102
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1461 5.95e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 58.63  E-value: 5.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELM 1433
Cdd:cd18250    21 FFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRE-SRADRVVLHGVSAEILGLLLDFSYTG---RVTVTQDNVEALL 96

                          90       100       110
                  ....*....|....*....|....*....|..
gi 442634029 1434 AAASFFQL----EGLLRYTEARcsemVDVDNV 1461
Cdd:cd18250    97 RAADLFQFpsvkEACCAYLQQR----LDVSNC 124
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1356-1466 8.20e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 57.82  E-value: 8.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1356 DVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELMAA 1435
Cdd:cd18199    20 DCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVFSSDAFSIILDFVYSG---KLSLTSQNVIEVMSA 96

                          90       100       110
                  ....*....|....*....|....*....|.
gi 442634029 1436 ASFFQlegllrytearcseMVDVDNVVAMYI 1466
Cdd:cd18199    97 ASYLQ--------------MTDVINVCKTFI 113
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1351-1460 9.09e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 58.04  E-value: 9.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1351 NPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPtVQINDIRYHIFQLVMQFLYCGGCSSLDvAHGDVL 1430
Cdd:cd18344    20 NSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNP-IEIHDLDPQVFKEMMGFIYTGKAPHLH-SHSMAC 97

                          90       100       110
                  ....*....|....*....|....*....|
gi 442634029 1431 ELMAAASFFQLEGLLRYTEARCSEMVDVDN 1460
Cdd:cd18344    98 DVLAAADKYGLEGLKVLCEDALCRNLSVEN 127
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 1347-1441 1.07e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 57.22  E-value: 1.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1347 KFVNNPELSDVTFRVEGKI-FYGHKIVLVTASPRFQSMLSSKLsegsstpTVQIN-DIRYHIFQLVMQFLYCGgcsSLDV 1424
Cdd:cd18299     5 NLLHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADLFLMMT-------VVTLDsDITPEAFRRVLEFLYTG---VLDE 74

                          90
                  ....*....|....*..
gi 442634029 1425 AHGDVLELMAAASFFQL 1441
Cdd:cd18299    75 NEDDLKELKDAAELLEL 91
BACK_ABTB2 cd18526
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 1456-1526 2.03e-09

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications in Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homologue (PTEN).


Pssm-ID: 350601  Cd Length: 79  Bit Score: 55.61  E-value: 2.03e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442634029 1456 VDVDNVVAMYIHAKVYNANRLLEFCQCFLLQNMVALLTyDDSVKRLLFAK--KIPNHDVLAGLLQTLQNRLKA 1526
Cdd:cd18526     1 INLENSVSIYKYAKIHNAPELASFCEGFFLKNMKALLE-QDSFRQLIYGRnsKVQGLDPLQDLQVTLAKRMHS 72
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1348-1465 2.32e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 57.53  E-value: 2.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1348 FVNNPELSDVTFRVE--------GKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGGC 1419
Cdd:cd18273    20 FYDARLLTDVTIEVNgpgsgpgsGRLFPCNRNVLAAASPYFKSMFTGGLYE-SKQETVTIHDVDSESMALIIDYCYTGRV 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 442634029 1420 SsldVAHGDVLELMAAASFFQLEGLLRYTEARCSEMVDVDNVVAMY 1465
Cdd:cd18273    99 T---LSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1353-1446 2.50e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 56.39  E-value: 2.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1353 ELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLEL 1432
Cdd:cd18257    17 ELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSE-KENSEVEFQCIDETALQAIVEYAYTG---TVFISQATVESL 92

                          90
                  ....*....|....
gi 442634029 1433 MAAASFFQLEGLLR 1446
Cdd:cd18257    93 LPAANLLQIKLVLK 106
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 270-428 2.80e-09

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 62.09  E-value: 2.80e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029   270 PNFVQHQAPSQVTGLPPV-------PPPQMQSPHQVQS--QLPPSQTPLSSQKGLAVAMATPAPRVFKELAQQPNKGMP- 339
Cdd:pfam03154  286 PSHMQHPVPPQPFPLTPQssqsqvpPGPSPAAPGQSQQriHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPq 365

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029   340 ------HKMVASSSSCSGGQANSSCKMP---SPGTASKALIPQRAVAGPARLTVQSTPVKSQPPQLSGsLSQSQVSPnrp 410
Cdd:pfam03154  366 lpnpqsHKHPPHLSGPSPFQMNSNLPPPpalKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPV-LTQSQSLP--- 441

                          170
                   ....*....|....*...
gi 442634029   411 ilgiPTTAANPTPPRIHQ 428
Cdd:pfam03154  442 ----PPAASHPPTSGLHQ 455
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 1347-1443 4.01e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 55.42  E-value: 4.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1347 KFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSklSEGSSTPTVQINDIR--YHIFQLVMQFLYcgGCsSLDV 1424
Cdd:cd18312     2 WFRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASS--SSESDPSEIELNDFPggAEAFELVAKFCY--GM-PINL 76

                          90
                  ....*....|....*....
gi 442634029 1425 AHGDVLELMAAASFFQLEG 1443
Cdd:cd18312    77 TATNVVGLRCAAEYLEMTE 95
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1356-1450 4.23e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 55.70  E-value: 4.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1356 DVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELMAA 1435
Cdd:cd18330    20 DCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSEAFSIILDFLYSG---KLDLCSENVIEVMSA 96

                          90
                  ....*....|....*
gi 442634029 1436 ASFFQLEGLLRYTEA 1450
Cdd:cd18330    97 ASYLQMTDVVNFCKG 111
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1351-1474 4.31e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 56.11  E-value: 4.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1351 NPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKlSEGSSTPTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDVL 1430
Cdd:cd18306    15 NRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSD-SDGESILTVKLDGLDPDAVEVLVNYAY---TSRLEVPADLVK 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 442634029 1431 ELMAAASFFQlegllrytearcseMVDVDNVVAMYIHAKVYNAN 1474
Cdd:cd18306    91 SVYSAAKKLK--------------MDRVKKACGDFLLEKLTPQN 120
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1006-1131 9.04e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.43  E-value: 9.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1006 DTQNSAGLTALMIASIRNDEVALHALLDAGCDPNVEVP-------PAGSAGYPAI------------QPDTQHWTALSFA 1066
Cdd:COG0666   147 NAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNdgetplhLAAENGHLEIvkllleagadvnAKDNDGKTALDLA 226

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442634029 1067 ASRANYVALRILLERGGKVEGGARSSeekctLTPLQLAAGTGNLEIVALLLAHGANAFLSTQQKD 1131
Cdd:COG0666   227 AENGNLEIVKLLLEAGADLNAKDKDG-----LTALLLAAAAGAALIVKLLLLALLLLAAALLDLL 286
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1348-1464 1.12e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 55.01  E-value: 1.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1348 FVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHG 1427
Cdd:cd18270    20 FYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQT-HVHLRNVDAATLQIIITYAYTG---NLAINDS 95

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 442634029 1428 DVLELMAAASFFQLEGLLRYTEARCSEMVDVDNVVAM 1464
Cdd:cd18270    96 TVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRL 132
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1351-1455 1.48e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 54.72  E-value: 1.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1351 NPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGGCSSLDVAHGDvl 1430
Cdd:cd18342    19 NSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEE-SKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADD-- 95

                          90       100
                  ....*....|....*....|....*.
gi 442634029 1431 eLMAAASFFQLEGL-LRYTEARCSEM 1455
Cdd:cd18342    96 -LLAAADKYALERLkVMCEDALCSNL 120
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1353-1444 1.61e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 54.61  E-value: 1.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1353 ELSDVTFRVE-GKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDVLE 1431
Cdd:cd18274    21 QLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTE-STQKEVRIVGVEAESMHLVLDYAY---TSRVTLTEANVQA 96

                          90
                  ....*....|...
gi 442634029 1432 LMAAASFFQLEGL 1444
Cdd:cd18274    97 LFTAASIFQIPSL 109
BACK_BTBD11 cd18527
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 11 (BTBD11); ...
 1456-1526 1.72e-08

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also termed ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. The BTBD11 gene has been identified as an all-trans retinoic acid-responsive gene that may play a role in neural development.


Pssm-ID: 350602  Cd Length: 83  Bit Score: 52.90  E-value: 1.72e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442634029 1456 VDVDNVVAMYIHAKVYNANRLLEFCQCFLLQNMVALLTyDDSVKRLLFAK--KIPNHDVLAGLLQTLQNRLKA 1526
Cdd:cd18527     1 INTENCVDIYNHAKFLGATELSSYCEGYFLKNMVLLIE-NEAFKQLLYDKngESPGQDVLQDLERTLATRIQS 72
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1353-1441 2.64e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 53.99  E-value: 2.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1353 ELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDVLEL 1432
Cdd:cd18249    22 ELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQT-EVTIRDIDERAMELLIDFAY---TSQITVEEGNVQTL 97


                  ....*....
gi 442634029 1433 MAAASFFQL 1441
Cdd:cd18249    98 LPAACLLQL 106
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1347-1438 2.86e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 53.26  E-value: 2.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1347 KFVNN-----PELSDVTFRVEGKIFYGHKIVLVTASPRFQsmlsSKLSEGSSTPTVQINDIRYHIFQLVMQFLYcggCSS 1421
Cdd:cd18226    10 KYLNDdrqkqSSFCDLVITVEGKEFSAHKVVVAVGSSYFH----ACLSKNPNTDAVTLDHVSYSVFQHLLEFLY---TSE 82

                          90
                  ....*....|....*..
gi 442634029 1422 LDVAHGDVLELMAAASF 1438
Cdd:cd18226    83 FFVYENEIPLVLEAAKF 99
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 1350-1446 3.25e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 53.42  E-value: 3.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1350 NNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYcGGCSSLDVAHgDV 1429
Cdd:cd18286    13 LNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSS-EITLTGVSHAAVSFVLLFIY-GGVLDLPDDV-NL 89

                          90
                  ....*....|....*..
gi 442634029 1430 LELMAAASFFQLEGLLR 1446
Cdd:cd18286    90 GELLSLADMYGLDGLKD 106
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1356-1466 3.87e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 53.29  E-value: 3.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1356 DVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELMAA 1435
Cdd:cd18329    23 DCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVFSPDTFTIILDFVYSG---KLSLTSQNVIEVMSA 99

                          90       100       110
                  ....*....|....*....|....*....|.
gi 442634029 1436 ASFFQlegllrytearcseMVDVDNVVAMYI 1466
Cdd:cd18329   100 ASYLQ--------------MTDVISVCKTFI 116
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1460 3.98e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 53.74  E-value: 3.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELM 1433
Cdd:cd18272    32 FADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNR-VIELKDVSESVFQLLVDYIYHG---TVKLRVEELQETY 107

                          90       100
                  ....*....|....*....|....*..
gi 442634029 1434 AAASFFQLEGLLRYTEARCSEMVDVDN 1460
Cdd:cd18272   108 EVADMYQLTALFEECSRFLARTVQVRN 134
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1347-1439 4.69e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 53.03  E-value: 4.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1347 KFVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYcggCSSLDVAH 1426
Cdd:cd18353    13 KEFDSPETSDLKFRVDGKYIHVHKAVLKIRCEHFRTMFQSHWNE-DMKEVIEIDQFSYPVYRAFLEYLY---TDSVDLPP 88

                          90
                  ....*....|...
gi 442634029 1427 GDVLELMAAASFF 1439
Cdd:cd18353    89 EDAIGLLDLATSY 101
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1350-1454 7.94e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 52.56  E-value: 7.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1350 NNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTP------TVQINDIRYHIFQLVMQFLYcggCSSLD 1423
Cdd:cd18228    15 NEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVspagkcVLDLHHVTVTGFAPLLEYAY---TSTLS 91

                          90       100       110
                  ....*....|....*....|....*....|.
gi 442634029 1424 VAHGDVLELMAAASFFQLEGLLryteARCSE 1454
Cdd:cd18228    92 INTENIIDVLAAASYMQMFNVA----NTCSE 118
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1063-1173 7.98e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.27  E-value: 7.98e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  1063 LSFAASRANYVALRILLERGGKVEggarsSEEKCTLTPLQLAAGTGNLEIVALLLAHganaflstqqkdslcFAGSAQKG 1142
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADAN-----LQDKNGRTALHLAAKNGHLEIVKLLLEH---------------ADVNLKDN 60

                           90       100       110
                   ....*....|....*....|....*....|.
gi 442634029  1143 CFCAISVAAAHGHRSCLRKLLTHPVSPGTRD 1173
Cdd:pfam12796   61 GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1446 1.05e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 51.98  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSmLSSKLSEGSSTPTV-QINDIRYHIFQLVMQFLYcggCSSLDVAHGDVLEL 1432
Cdd:cd18230    21 LCDVCIIVEGKIFKAHKNVLLGSSRYFKT-LYCQVQKTSDQATVtHLDIVTAQGFKAIIDFMY---SAHLALTSKNVIEV 96

                          90
                  ....*....|....
gi 442634029 1433 MAAASFFQLEGLLR 1446
Cdd:cd18230    97 MSAASYLQMTDIVQ 110
PHA03098 PHA03098
kelch-like protein; Provisional
 1357-1496 1.43e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 55.93  E-value: 1.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1357 VTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGsstpTVQINdIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELMAAA 1436
Cdd:PHA03098   14 IIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKEN----EINLN-IDYDSFNEVIKYIYTG---KINITSNNVKDILSIA 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1437 SFFQLEGLLRYTEARCSEMVDVDNVVAMYIHAKVYNANRLLEFCQCFLLQNMVALLTYDD 1496
Cdd:PHA03098   86 NYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPD 145
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 1351-1456 1.78e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 51.92  E-value: 1.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1351 NPEL--SDVTFRVE-GKIFYGHKIVLVTASPRFQSMLSSKLSEGSST-PTVQIND------IRYHIFQLVMQFLYCG--- 1417
Cdd:cd18310    13 SPDLfySDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGANTkPKLELRElipggiVGYDAFMLVLSYLYSGrlr 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 442634029 1418 -------GCSSLDVAHGD-------VLELMAAASFFQLEGLLRYTEARCSEMV 1456
Cdd:cd18310    93 lvpkegsACVDSDCWHVAcrpavdfALEVLYAASVFQIPELVSLFQRRLLDFV 145
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1460 1.88e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 51.24  E-value: 1.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDVLELM 1433
Cdd:cd18255    18 LLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRE-SSQDEIELKGVSAKGLKHILDFAY---TSELTLDLDCIQDVL 93

                          90       100
                  ....*....|....*....|....*..
gi 442634029 1434 AAASFFQLEGLLRYTEARCSEMVDVDN 1460
Cdd:cd18255    94 GAAVHLQMLPVVELCEEFLKSAMSVEN 120
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1444 2.09e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 51.57  E-value: 2.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDVLELM 1433
Cdd:cd18246    39 LCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQT-HVTLHDIDPQALEQLVQYAY---TAEIVVGEGNVQTLL 114

                          90
                  ....*....|.
gi 442634029 1434 AAASFFQLEGL 1444
Cdd:cd18246   115 PAASLLQLNGV 125
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1348-1417 2.55e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 50.42  E-value: 2.55e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442634029 1348 FVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLS-SKLSEGSSTPTVQINDIRYHIFQLVMQFLYCG 1417
Cdd:cd18245     8 FREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNyNPPKDDGSTYKIELEGISVEVMEEILDYIYTG 78
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1457 3.28e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 50.81  E-value: 3.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSskLSEGSstpTVQINDIRY-HIFQLVMQFLYCGG-CSSLdvahGDVLE 1431
Cdd:cd18222    25 LCDIVVNVQGQSFRAHKVVLAASSPYFRDHMS--LNEMS---TVSISVIKNpTVFEQLLSFCYTGRiCLQL----ADIIS 95

                          90       100
                  ....*....|....*....|....*.
gi 442634029 1432 LMAAASFFQLEGLLRyteaRCSEMVD 1457
Cdd:cd18222    96 YLTAASFLQMQHIID----KCTQILE 117
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1351-1447 8.16e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 49.25  E-value: 8.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1351 NPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVL 1430
Cdd:cd18240    14 EGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKK-VYKIPGVSPEMMELIIEYAYTR---TVPITAENVE 89

                          90
                  ....*....|....*..
gi 442634029 1431 ELMAAASFFQLEGLLRY 1447
Cdd:cd18240    90 ELLPAADQFNIMGIVKA 106
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1356-1442 9.03e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 49.09  E-value: 9.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1356 DVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVQINDIRyhifQLVmQFLYCGgcsSLDVAHGDVLELMAA 1435
Cdd:cd18229    20 DVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPVVPAQTVR----QLV-EFMYSG---SLVVAQSEALQILTA 91


                  ....*..
gi 442634029 1436 ASFFQLE 1442
Cdd:cd18229    92 ASILQIK 98
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1464 9.37e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 49.40  E-value: 9.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELM 1433
Cdd:cd18268    23 LTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRE-SSQAKVDLKGIDSDVLDQIVDYVYTG---EILITRDNVLPLM 98

                          90       100       110
                  ....*....|....*....|....*....|.
gi 442634029 1434 AAASFFQLEGLLRYTEARCSEMVDVDNVVAM 1464
Cdd:cd18268    99 EAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1441 1.38e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 48.96  E-value: 1.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDVLELM 1433
Cdd:cd18235    21 LCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSE-SRANRVTLQDVDGKALLLLIDYVY---TAEIQVTEENVQVLL 96


                  ....*...
gi 442634029 1434 AAASFFQL 1441
Cdd:cd18235    97 PAANLLQL 104
BTB_POZ_BTBD12_SLX4 cd18288
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1349-1449 1.44e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349597 [Multi-domain]  Cd Length: 116  Bit Score: 48.61  E-value: 1.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1349 VNNPELSDVTFRVE-GKIFYGHKIVLVTASPRFQSMLSSK--LSEGSSTPTVQ---INDIRYHIFQLVMQFLYCGGCssl 1422
Cdd:cd18288    13 VNNPHLSDVQFQTDsGEVLYAHSFVLYARCPLLIQMVHSEgfSVEEEGGVTTRrvlLGDVSGEAARCFLQYLYTADT--- 89

                          90       100
                  ....*....|....*....|....*..
gi 442634029 1423 DVAHGDVLELMAAASFFQLEGLLRYTE 1449
Cdd:cd18288    90 GLPPGLSPHVSELADRFGVSELVHLCE 116
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1350-1440 1.76e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 48.40  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1350 NNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgsstpTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDV 1429
Cdd:cd18354    16 DNPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEE-----IIEMSQFSYPVYRAFLEYLY---TDSISLSPEDA 87

                          90
                  ....*....|.
gi 442634029 1430 LELMAAASFFQ 1440
Cdd:cd18354    88 IGLLDLATFYR 98
HFD_H2A cd00074
histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core ...
 676-723 3.14e-06

histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.


Pssm-ID: 467020  Cd Length: 89  Bit Score: 46.76  E-value: 3.14e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 442634029  676 QSKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEI 723
Cdd:cd00074     1 QSRSKRAGLQFPVGRIHRLLKKGTYAKRVGAGAPVYLAAVLEYLTAEI 48
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 1352-1415 3.34e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 47.36  E-value: 3.34e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442634029 1352 PELSDVTFR-VEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVQInDIRYHIFQLVMQFLY 1415
Cdd:cd18302     3 SDLYDVTIVsEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTM-PIPSDILEIILDYLY 66
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1460 3.66e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 47.52  E-value: 3.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELM 1433
Cdd:cd18253    18 FTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREM-LVEINGILAEAMDCFLQYVYTG---KVKITTENVQYLF 93

                          90       100
                  ....*....|....*....|....*..
gi 442634029 1434 AAASFFQLEGLLRYTEARCSEMVDVDN 1460
Cdd:cd18253    94 ETSSLFQISPLRDACAKFLEEQLDPCN 120
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1351-1440 3.89e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 47.90  E-value: 3.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1351 NPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVL 1430
Cdd:cd18259    29 NPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVE-SISARVEIKDVDPAVMESLIDFAYTG---KLTINQGNVE 104

                          90
                  ....*....|
gi 442634029 1431 ELMAAASFFQ 1440
Cdd:cd18259   105 ALIRTSNRLQ 114
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 1353-1452 3.92e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 47.24  E-value: 3.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1353 ELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLsegSSTPTVQIND--IRYHIFQLVMQFLYCGgcsSLDVAHGDVL 1430
Cdd:cd18295    18 SYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKW---KDKREINLKHplVNPDAFRALLQYLYTG---RLEIHVDDVE 91

                          90       100
                  ....*....|....*....|..
gi 442634029 1431 ELMAAASFFQLEGLLRYTEARC 1452
Cdd:cd18295    92 DCKRLAKQCRLEELIEELEAKC 113
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1441 4.38e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 47.26  E-value: 4.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVQINDI-RYHIFQLVMQFLYCGgcsSLDVAHGDVLEL 1432
Cdd:cd18201    21 LCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTTVTHLDVvAVQGFSVILDFMYSG---NLVLTSQNAIEV 97


                  ....*....
gi 442634029 1433 MAAASFFQL 1441
Cdd:cd18201    98 MSVASYLQM 106
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1444 1.11e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 45.99  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSK----LSEGSSTPTVqindiryhiFQLVMQFLYCGGCSSLDVAHGDV 1429
Cdd:cd18216    20 LCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHDnlihLDQDMVSPTV---------FQQILDFIYTGKLLDSLFEEPNL 90

                          90
                  ....*....|....*
gi 442634029 1430 LELMAAASFFQLEGL 1444
Cdd:cd18216    91 SEVLAAANYLQLPDL 105
PTZ00017 PTZ00017
histone H2A; Provisional
 677-723 1.28e-05

histone H2A; Provisional


Pssm-ID: 185399  Cd Length: 134  Bit Score: 46.28  E-value: 1.28e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 442634029  677 SKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEI 723
Cdd:PTZ00017   19 SRSAKAGLQFPVGRVHRYLKKGRYAKRVGAGAPVYLAAVLEYLTAEV 65
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1441 1.47e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 45.87  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDVLELM 1433
Cdd:cd18339    21 LCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSE-SKAKKIEIKDVDGQTLSKLIDYIY---TAEIEVTEENVQVLL 96


                  ....*...
gi 442634029 1434 AAASFFQL 1441
Cdd:cd18339    97 PAASLLQL 104
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1356-1461 1.48e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 46.11  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1356 DVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDVLELMAA 1435
Cdd:cd18207    29 DVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMHTISSKVFGDILDFAY---TSRIVVRLESFPELMTA 105

                          90       100
                  ....*....|....*....|....*.
gi 442634029 1436 ASFFqlegLLRYTEARCSEMVDVDNV 1461
Cdd:cd18207   106 AKFL----LMRSVIDICQEVIKQSNV 127
H2A smart00414
Histone 2A;
677-723 1.83e-05

Histone 2A;


Pssm-ID: 197711  Cd Length: 106  Bit Score: 45.02  E-value: 1.83e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 442634029    677 SKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEI 723
Cdd:smart00414    1 SRSARAGLQFPVGRIHRLLRKGTYAKRVGAGAPVYLAAVLEYLTAEV 47
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1353-1442 2.20e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 45.57  E-value: 2.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1353 ELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDVLEL 1432
Cdd:cd18276    20 ELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLME-CSQREVVLHDITAESVSIILNYMY---SSDLHLTNSNVQGV 95

                          90
                  ....*....|
gi 442634029 1433 MAAASFFQLE 1442
Cdd:cd18276    96 ATAAFFLQME 105
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1347-1441 2.71e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 45.47  E-value: 2.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1347 KFVnnpelsDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCggcSSLDVAH 1426
Cdd:cd18269    26 KFV------DCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEE-SKKKEVVLEDVDPDVMGMILKYLYT---SEIDLND 95

                          90
                  ....*....|....*
gi 442634029 1427 GDVLELMAAASFFQL 1441
Cdd:cd18269    96 QNVQDIFALASRFQI 110
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1099-1178 3.11e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 48.54  E-value: 3.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  1099 TPLQLAAGTGNLEIVALLLAHGA--------NAFLSTQQKDSLCFAGSaqkgcfcAISVAAAHGHRSCLRKLLTHPVSPG 1170
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERGAsvparacgDFFVKSQGVDSFYHGES-------PLNAAACLGSPSIVALLSEDPADIL 202


                   ....*...
gi 442634029  1171 TRDVLSLE 1178
Cdd:TIGR00870  203 TADSLGNT 210
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1002-1133 4.84e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 47.95  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1002 TTRYDTQNSAGLTALMIASIRNDEVALHA---LLDAGCDPNVEVPPAGSagyPAIQPDTQHWTALSFAASRANYVALRIL 1078
Cdd:cd21882    16 TDSAYQRGATGKTCLHKAALNLNDGVNEAimlLLEAAPDSGNPKELVNA---PCTDEFYQGQTALHIAIENRNLNLVRLL 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442634029 1079 LERGGKVEG---GARSSEEKCTLT-----PLQLAAGTGNLEIVALLLAHGANAfLSTQQKDSL 1133
Cdd:cd21882    93 VENGADVSAratGRFFRKSPGNLFyfgelPLSLAACTNQEEIVRLLLENGAQP-AALEAQDSL 154
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1442 5.21e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 44.08  E-value: 5.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVQiNDIRYHIFQLVMQFLYcggCSSLDVAHGDVLELM 1433
Cdd:cd18332    19 LTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLP-SGLEARGFQLLLDFMY---TSRLPLTPRTVPAVL 94


                  ....*....
gi 442634029 1434 AAASFFQLE 1442
Cdd:cd18332    95 AAATYLQME 103
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1442 5.76e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 44.29  E-value: 5.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDVLELM 1433
Cdd:cd18338    21 LCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSE-SRAKRVRIKEVDGWTLKMLIDYVY---TAEIQVTEENVQVLL 96


                  ....*....
gi 442634029 1434 AAASFFQLE 1442
Cdd:cd18338    97 PAAGLLQLQ 105
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1350-1445 6.50e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 43.90  E-value: 6.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1350 NNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVQINDIryhifQLVMQFLYCGgcsSLDVAHGDV 1429
Cdd:cd18208    21 NRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSV-----QKLIDFMYSG---VLRVSQSEA 92

                          90
                  ....*....|....*.
gi 442634029 1430 LELMAAASFFQLEGLL 1445
Cdd:cd18208    93 LQILTAASILQIKTVI 108
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 1355-1430 7.13e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 43.09  E-value: 7.13e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442634029 1355 SDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPT-VQINDIRYHIFQLVMQFLYCGGCSSLD--VAHGDVL 1430
Cdd:cd18283     3 TDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVdLPTAGIDVPMFSALLRYLYTGEFGSEDsrSQNLDVL 81
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 987-1133 7.21e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 47.38  E-value: 7.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029   987 GRAELLAQAAQ--------LLPpttRYDTQNSAGLTALMIAS---IRNDEVALHALLDAGCD---PNVEVPPAGSAGYPA 1052
Cdd:TIGR00870   52 GRSALFVAAIEnenlelteLLL---NLSCRGAVGDTLLHAISleyVDAVEAILLHLLAAFRKsgpLELANDQYTSEFTPG 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  1053 IqpdtqhwTALSFAASRANYVALRILLERGGKVEggARSSEEKCTLT-----------PLQLAAGTGNLEIVALLLAHGA 1121
Cdd:TIGR00870  129 I-------TALHLAAHRQNYEIVKLLLERGASVP--ARACGDFFVKSqgvdsfyhgesPLNAAACLGSPSIVALLSEDPA 199

                          170
                   ....*....|..
gi 442634029  1122 NafLSTQqkDSL 1133
Cdd:TIGR00870  200 D--ILTA--DSL 207
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 964-1122 7.50e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.56  E-value: 7.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  964 IGEDTSELGRRATIGVAfkllLTGRAELLAQaaqLLPPTTRYDTQNSAGLTALMIASIRNDEVALHALLDAGCDPNVEVP 1043
Cdd:PLN03192  517 GGEHDDPNMASNLLTVA----STGNAALLEE---LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDA 589

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1044 PAGSAGYPAIQPDTQ-------HWTALS----------FAASRANYVALRILLERGGKVEggarsSEEKCTLTPLQLAAG 1106
Cdd:PLN03192  590 NGNTALWNAISAKHHkifrilyHFASISdphaagdllcTAAKRNDLTAMKELLKQGLNVD-----SEDHQGATALQVAMA 664

                         170
                  ....*....|....*.
gi 442634029 1107 TGNLEIVALLLAHGAN 1122
Cdd:PLN03192  665 EDHVDMVRLLIMNGAD 680
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1350-1446 9.41e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 43.15  E-value: 9.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1350 NNPELSDVTFRV----EGKIFYGHKIVLVTASPRFQSMLSSKLSEGSStpTVQINDIRYHIFQLVMQFLYcggCSSLDVA 1425
Cdd:cd18282     3 NNELMADVHFIVgppgGTQRIPAHKYVLATGSSVFYAMFYGGLAENKN--EIEIPDVEPAAFLNLLRYLY---CDEIDLE 77

                          90       100
                  ....*....|....*....|.
gi 442634029 1426 HGDVLELMAAASFFQLEGLLR 1446
Cdd:cd18282    78 PDTVLATLYAAKKYLVPHLAR 98
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1351-1455 1.49e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 42.65  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1351 NPELSDVTFRVEGKIFYGHKIVLVTaSPRFQSMLSSKLSEGSSTP-TVQIND--IRYHIFQLVMQFLYCGGCSsLDVAHg 1427
Cdd:cd18305    12 NGENSDITICALGREWKLHKIYLCQ-SGYFASMFSGSWKESKETViNLEIPDdnITVEALNVVFGSLYRDEIE-IKPSR- 88

                          90       100
                  ....*....|....*....|....*...
gi 442634029 1428 dVLELMAAASFFQLEGLLRyteaRCSEM 1455
Cdd:cd18305    89 -VVSILAAATLLQLDGLIQ----QCSEV 111
PHA03247 PHA03247
large tegument protein UL36; Provisional
 255-424 1.76e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  255 QEWRRAAKRPTgnlppnfvqhqaPSQVTGLPPVPPPQMQ---SPHQVQSQLPPSQTPLSSQKGLAVAMATPAPRVFKELA 331
Cdd:PHA03247 2681 QRPRRRAARPT------------VGSLTSLADPPPPPPTpepAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGP 2748

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  332 QQPNKGMPhkmVASSSSCSGGQANSSCKMPSPGTASKALIPQRAVAGPARLTVQSTPVKSQPPQLSGSLSQSQVSPNRPI 411
Cdd:PHA03247 2749 ATPGGPAR---PARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825

                         170
                  ....*....|....
gi 442634029  412 LGI-PTTAANPTPP 424
Cdd:PHA03247 2826 GPLpPPTSAQPTAP 2839
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1356-1441 1.80e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 42.90  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1356 DVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDVLELMAA 1435
Cdd:cd18340    29 DCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEE-SKKREIVLEDVDPDVMGKILHYIY---TSEIEITEQNVQDIFAA 104


                  ....*.
gi 442634029 1436 ASFFQL 1441
Cdd:cd18340   105 ANMFQI 110
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1447 2.78e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 42.64  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELM 1433
Cdd:cd18244    30 LLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRE-RDQDKIHLKGLTATGFSHVLQFMYYG---TIELSMLTVHEIL 105

                          90
                  ....*....|....
gi 442634029 1434 AAASFFQLEGLLRY 1447
Cdd:cd18244   106 QAAMYVQLTEVVKF 119
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1353-1460 3.17e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 42.23  E-value: 3.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1353 ELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVqindIRYHIFQLVMQFLYCGGcssLDVAHGDVLEL 1432
Cdd:cd18227    24 QLCDISVVVQGHLFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDV----MNPRVFENILLSCYTGR---LVLPAPEIVSY 96

                          90       100
                  ....*....|....*....|....*...
gi 442634029 1433 MAAASFFQLEGLLRyteaRCSEMVDVDN 1460
Cdd:cd18227    97 LTAASFLQMWHVVD----KCTELLEGNP 120
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1451 3.65e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 42.12  E-value: 3.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSklsEGSSTPTVQIND--IRYHIFQLVMQFLYCGgcsSLDVAHGDVLE 1431
Cdd:cd18323    23 LCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKE---QLDKRDLVCINNeiVTAPAFSLLLEFMYEG---RLSFNDTPVED 96

                          90       100
                  ....*....|....*....|
gi 442634029 1432 LMAAASFFQLEGLLRYTEAR 1451
Cdd:cd18323    97 VLAAASYLHMNDIVKVCKKR 116
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1347-1441 3.75e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 42.14  E-value: 3.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1347 KFVnnpelsDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYcggCSSLDVAH 1426
Cdd:cd18341    26 KFV------DCTLKAGDKSLPCHRLILAACSPYFREYFLSEESE-EKKKEVVLDNVDPNIMDMILKYLY---SAEIDLND 95

                          90
                  ....*....|....*
gi 442634029 1427 GDVLELMAAASFFQL 1441
Cdd:cd18341    96 GNVQDIFALASRFQI 110
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 998-1133 3.95e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 3.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029  998 LLPPTTRYDTQNSAGLTALMIASIR-NDEVALhALLDagCDPNVEVPPAGSAGYpaiqpdtQHWTALSFAASRANYVALR 1076
Cdd:cd22192    37 LKCPSCDLFQRGALGETALHVAALYdNLEAAV-VLME--AAPELVNEPMTSDLY-------QGETALHIAVVNQNLNLVR 106

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442634029 1077 ILLERGGKVE-----GGARSSEEKCTLT----PLQLAAGTGNLEIVALLLAHGANaflsTQQKDSL 1133
Cdd:cd22192   107 ELIARGADVVspratGTFFRPGPKNLIYygehPLSFAACVGNEEIVRLLIEHGAD----IRAQDSL 168
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 1457-1496 4.45e-04

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 39.57  E-value: 4.45e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 442634029 1457 DVDNVVAMYIHAKVYNANRLLEFCQCFLLQNMVALLTYDD 1496
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEE 40
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1353-1457 4.74e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 41.55  E-value: 4.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1353 ELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVQindiRYHIFQLVMQFLYCGgcsSLDVAHGDVLEL 1432
Cdd:cd18220    24 KLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIK----NPNVFEQLLSFCYTG---RMSLQLKDVVSF 96

                          90       100
                  ....*....|....*....|....*
gi 442634029 1433 MAAASFFQLEGLLRyteaRCSEMVD 1457
Cdd:cd18220    97 LTAASFLQMQCVID----KCTQILE 117
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1356-1445 5.40e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 41.56  E-value: 5.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1356 DVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVqindIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELMAA 1435
Cdd:cd18290    29 DVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAA----VQPQSFQQILSFCYTG---RLSMNVGDQFLLMYT 101

                          90
                  ....*....|
gi 442634029 1436 ASFFQLEGLL 1445
Cdd:cd18290   102 AGFLQIQEIM 111
HTA1 COG5262
Histone H2A [Chromatin structure and dynamics];
676-723 5.60e-04

Histone H2A [Chromatin structure and dynamics];


Pssm-ID: 227587 [Multi-domain]  Cd Length: 132  Bit Score: 41.77  E-value: 5.60e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 442634029  676 QSKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEI 723
Cdd:COG5262    17 QSRSAKAGLIFPVGRVKRLLKKGNYRMRIGAGAPVYLAAVLEYLAAEI 64
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1442 6.20e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 41.00  E-value: 6.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVQiNDIRYHIFQLVMQFLYcggCSSLDVAHGDVLELM 1433
Cdd:cd18331    24 LTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLD-PEINPEGFNILLDFMY---TSRLNLREGNIMAVM 99


                  ....*....
gi 442634029 1434 AAASFFQLE 1442
Cdd:cd18331   100 ATAMYLQME 108
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1441 6.29e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 41.34  E-value: 6.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDVLELM 1433
Cdd:cd18251    23 LFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQT-EVLIHGVSYNAMCKILDFIY---TSELELSLDNVQETL 98


                  ....*...
gi 442634029 1434 AAASFFQL 1441
Cdd:cd18251    99 TAACQLQI 106
Ank_2 pfam12796
Ankyrin repeats (3 copies);
997-1085 6.75e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.10  E-value: 6.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029   997 QLLPPTTRYDTQNSAGLTALMIASIRNDEVALHALLDagcdpnvevppagsagYPAIQPDTQHWTALSFAASRANYVALR 1076
Cdd:pfam12796   15 LLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE----------------HADVNLKDNGRTALHYAARSGHLEIVK 78


                   ....*....
gi 442634029  1077 ILLERGGKV 1085
Cdd:pfam12796   79 LLLEKGADI 87
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1444 8.35e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 40.91  E-value: 8.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYCGGcssLDVAHGDVLELM 1433
Cdd:cd18265    23 FTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKE-SRQAVVEIQKVSAAAMEVLLDYMYGGG---LRIQEDNVESVL 98

                          90
                  ....*....|.
gi 442634029 1434 AAASFFQLEGL 1444
Cdd:cd18265    99 EASDLLQVSKL 109
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1353-1458 9.17e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 40.41  E-value: 9.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1353 ELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLssKLSEGSSTPTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDVLEL 1432
Cdd:cd18204    17 EFCDIAIVVEDVKFRAHRCVLAACSTYFKKLF--KKLEVDSSSVIEIDFLRSDIFEEVLNYMY---TAKISVKKEDVNLM 91

                          90       100
                  ....*....|....*....|....*.
gi 442634029 1433 MAAAsffQLEGlLRYTEARCSEMVDV 1458
Cdd:cd18204    92 MSSG---QILG-IRFLDKLCSQKRDV 113
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1356-1445 9.52e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 40.17  E-value: 9.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1356 DVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTPTVQInDIRYHIFQLVMQ---FLYCGgcsSLDVAHGDVLEL 1432
Cdd:cd18307     3 DVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDELSITI-DCDYLSPETVEQlldYFYTG---KIVISEKNVEDL 78

                          90
                  ....*....|...
gi 442634029 1433 MAAASFFQLEGLL 1445
Cdd:cd18307    79 LKGAKYFNIPRLK 91
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 1348-1458 1.08e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 40.22  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1348 FVNNPELSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYCGGCssldvahg 1427
Cdd:cd18360     4 FFNSPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSF-LVPIYGVSKDTFLSFLEYLYTDSC-------- 74

                          90       100       110
                  ....*....|....*....|....*....|.
gi 442634029 1428 dvlelmAAASFFQLEGLLryteaRCSEMVDV 1458
Cdd:cd18360    75 ------CPASILQAMALL-----ICAEMYQV 94
Ank_4 pfam13637
Ankyrin repeats (many copies);
1059-1117 1.72e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 1.72e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 442634029  1059 HWTALSFAASRANYVALRILLERGgkVEGGARSseeKCTLTPLQLAAGTGNLEIVALLL 1117
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKG--ADINAVD---GNGETALHFAASNGNVEVLKLLL 54
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1441 2.30e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 39.83  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEgSSTPTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDVLELM 1433
Cdd:cd18236    24 LTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKE-KYEEKIIIKGVDAETMQILLDYTY---TSKVLITKQNVQRVL 99


                  ....*...
gi 442634029 1434 AAASFFQL 1441
Cdd:cd18236   100 EAASLFQF 107
PLN00155 PLN00155
histone H2A; Provisional
 677-719 3.18e-03

histone H2A; Provisional


Pssm-ID: 165723  Cd Length: 58  Bit Score: 37.38  E-value: 3.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 442634029  677 SKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENL 719
Cdd:PLN00155   16 SRSAKAGLQFPVGRIARYLKKGKYAERIGAGAPVYLAAVLEYL 58
PLN00157 PLN00157
histone H2A; Provisional
 670-723 3.52e-03

histone H2A; Provisional


Pssm-ID: 177758  Cd Length: 132  Bit Score: 39.45  E-value: 3.52e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 442634029  670 GESALKQ-SKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEI 723
Cdd:PLN00157   10 GGGGKKAtSRSAKAGLQFPVGRIARYLKAGKYATRVGAGAPVYLAAVLEYLAAEV 64
PLN00153 PLN00153
histone H2A; Provisional
 677-732 3.99e-03

histone H2A; Provisional


Pssm-ID: 165721 [Multi-domain]  Cd Length: 129  Bit Score: 38.93  E-value: 3.99e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 442634029  677 SKSARAGLQLSVGRFYRWMTDARLGKFIHEYAAVYLCAGIENLLEEIaLQCNGTTA 732
Cdd:PLN00153   16 SRSAKAGLQFPVGRIARYLKKGKYAERIGAGAPVYLAAVLEYLTAEV-LELAGNAA 70
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1444 4.12e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 38.79  E-value: 4.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSS----KLSEGSSTPTVqindiryhiFQLVMQFLYCGGCSSLD-VAHGD 1428
Cdd:cd18334    21 LCDVIIVVENALFRAHKNILAASSMYFKSLVLHdnliNLDTDMVNPTV---------FRQILDFIYTGKLLTSDqPGEQN 91

                          90
                  ....*....|....*.
gi 442634029 1429 VLELMAAASFFQLEGL 1444
Cdd:cd18334    92 FNALLTAASYLQLHDL 107
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1099-1122 4.33e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.11  E-value: 4.33e-03
                           10        20
                   ....*....|....*....|....*
gi 442634029  1099 TPLQLAAG-TGNLEIVALLLAHGAN 1122
Cdd:pfam00023    4 TPLHLAAGrRGNLEIVKLLLSKGAD 28
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1444 4.73e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 38.38  E-value: 4.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRfqsmLSSKLSEGSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELM 1433
Cdd:cd18218    18 LCDTLITVGSQEFPAHSLVLAGASQQ----LGRQLTNPNPGQWCLGEGISPSTFKQLLDFVYGE---SVEVQPGELRPLL 90

                          90
                  ....*....|.
gi 442634029 1434 AAASFFQLEGL 1444
Cdd:cd18218    91 EAARALEVESL 101
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 1356-1445 4.86e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 38.64  E-value: 4.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1356 DVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELMAA 1435
Cdd:cd18263    15 DVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQS-VVQLPTIPAKDLRLLISFAYSG---ILHLSWENLFEATCT 90

                          90
                  ....*....|
gi 442634029 1436 ASFFQLEGLL 1445
Cdd:cd18263    91 ALQLQISGAL 100
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1441 4.87e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 38.12  E-value: 4.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELM 1433
Cdd:cd18234     1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEE-EIKLKDVDPDALWTLVQYCYTG---RLELKEDNVESLL 76


                  ....*...
gi 442634029 1434 AAASFFQL 1441
Cdd:cd18234    77 ATACLLQL 84
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1355-1460 5.09e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 38.65  E-value: 5.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1355 SDVTFR-VEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSSTpTVQINDIRYHIFQLVMQFLYcggCSSLDVAHGDVLELM 1433
Cdd:cd18252    22 TDITLQcASGQIFHCHKAALAACSSYFKVMFTADMKEKSNN-VIKLSGIDHDILEALVNYVY---TSQICITERNVQSLL 97

                          90       100
                  ....*....|....*....|....*..
gi 442634029 1434 AAASFFQLEGLLRYTEARCSEMVDVDN 1460
Cdd:cd18252    98 EAADLLQFISVKKACEQFLVRHLDIDN 124
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1446 5.62e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 38.24  E-value: 5.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSStpTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELM 1433
Cdd:cd18212    23 LCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQS--IYMLEGMVAETFGALLEFIYTG---CLQVGEKSLEQIL 97

                          90
                  ....*....|...
gi 442634029 1434 AAASFFQLEGLLR 1446
Cdd:cd18212    98 ATAQFLKVNDLVK 110
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1356-1436 6.80e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 37.82  E-value: 6.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1356 DVTFRVEGKIFYGHKIVLVTASPRFQSmlsskLSEGSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELMAA 1435
Cdd:cd18232    20 DATLDVGGRVFKAHWSVLACCSHFFQS-----LYGDGTSGSVVLPESFAEVFGLLLDFFYTG---ELALTRENRDRVLLA 91


                  .
gi 442634029 1436 A 1436
Cdd:cd18232    92 A 92
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1354-1446 6.87e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 38.26  E-value: 6.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442634029 1354 LSDVTFRVEGKIFYGHKIVLVTASPRFQSMLSSKlsegSSTPTVQINDIRYHIFQLVMQFLYCGgcsSLDVAHGDVLELM 1433
Cdd:cd18260    18 LCDLTIATKTKSFDVHKVVMASCSEYFRNILKKD----PSLQRVELNDISPLGLATVITYAYTG---KLTLSLYTIGSTI 90

                          90
                  ....*....|...
gi 442634029 1434 AAASFFQLEGLLR 1446
Cdd:cd18260    91 SAASYLQIHALVK 103
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 1456-1492 7.39e-03

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


Pssm-ID: 350575  Cd Length: 60  Bit Score: 36.34  E-value: 7.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442634029 1456 VDVDNVVAMYIHAKVYNANRLLEFCQCFLLQNMVALL 1492
Cdd:cd18500     1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLL 37
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1099-1122 8.24e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 8.24e-03
                            10        20
                    ....*....|....*....|....
gi 442634029   1099 TPLQLAAGTGNLEIVALLLAHGAN 1122
Cdd:smart00248    4 TPLHLAAENGNLEVVKLLLDKGAD 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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