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Conserved domains on  [gi|442617837|ref|NP_001262336|]
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stranded at second, isoform C [Drosophila melanogaster]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10676162)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VWC smart00214
von Willebrand factor (vWF) type C domain;
752-824 1.30e-08

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 52.52  E-value: 1.30e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442617837    752 CTFKGAEYDVGQQFRDGCDQLCICNEQG-IHCAKLECPSNfgldvqdPHCIRWEPVPAdfkpsPPNCCPesmRC 824
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPP-------PDCPNPERVKP-----PGECCP---RC 59
fn3 pfam00041
Fibronectin type III domain;
1068-1134 1.53e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.53e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442617837  1068 LTVSETNASWLQLTWKKLGDDQMEyVDGVQLRYKELTGMIYSSTPLIHRTLTSYTIQNLQPDTGYEI 1134
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGNGP-ITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1171-1260 4.09e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.34  E-value: 4.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617837 1171 VNVTKVKTQSVEISWNGVPYPEDKFVHiYRaIYQSDAGKEDSSVFKVAKRDSTTgTLIMDLKPGTKYRLWLEMYLTNGNT 1250
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEDDGGPITG-YV-VEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGGGES 83

                          90
                  ....*....|
gi 442617837 1251 KKSNVVNFIT 1260
Cdd:cd00063    84 PPSESVTVTT 93
 
Name Accession Description Interval E-value
VWC smart00214
von Willebrand factor (vWF) type C domain;
752-824 1.30e-08

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 52.52  E-value: 1.30e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442617837    752 CTFKGAEYDVGQQFRDGCDQLCICNEQG-IHCAKLECPSNfgldvqdPHCIRWEPVPAdfkpsPPNCCPesmRC 824
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPP-------PDCPNPERVKP-----PGECCP---RC 59
fn3 pfam00041
Fibronectin type III domain;
1068-1134 1.53e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.53e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442617837  1068 LTVSETNASWLQLTWKKLGDDQMEyVDGVQLRYKELTGMIYSSTPLIHRTLTSYTIQNLQPDTGYEI 1134
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGNGP-ITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1171-1260 4.09e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.34  E-value: 4.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617837 1171 VNVTKVKTQSVEISWNGVPYPEDKFVHiYRaIYQSDAGKEDSSVFKVAKRDSTTgTLIMDLKPGTKYRLWLEMYLTNGNT 1250
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEDDGGPITG-YV-VEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGGGES 83

                          90
                  ....*....|
gi 442617837 1251 KKSNVVNFIT 1260
Cdd:cd00063    84 PPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1066-1145 5.10e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 5.10e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617837   1066 PELTVSETNASWLQLTWKK-LGDDQMEYVDGVQLRYKELTGMiySSTPLIHRTLTSYTIQNLQPDTGYEIGLYYIPLAGH 1144
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 442617837   1145 G 1145
Cdd:smart00060   83 G 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1068-1146 8.51e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 8.51e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442617837 1068 LTVSETNASWLQLTWKKLGDDQMEyVDGVQLRYKELTGMIYSSTPLIHRTLTSYTIQNLQPDTGYEIGLYYIPLAGHGA 1146
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEDDGGP-ITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1171-1241 7.45e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.60  E-value: 7.45e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442617837   1171 VNVTKVKTQSVEISWNGvpyPEDKFVHIYRAIYQSDAGKEDSSVFKVAKRDSTTGTLIMDLKPGTKYRLWL 1241
Cdd:smart00060    7 LRVTDVTSTSVTLSWEP---PPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
fn3 pfam00041
Fibronectin type III domain;
1171-1253 2.94e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.86  E-value: 2.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617837  1171 VNVTKVKTQSVEISWNGVPYPEDKFVHiYRAIYQSDAGKEDSSVFKVAKrdSTTGTLIMDLKPGTKYRLWLEMYLTNGNT 1250
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGNGPITG-YEVEYRPKNSGEPWNEITVPG--TTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 442617837  1251 KKS 1253
Cdd:pfam00041   83 PPS 85
 
Name Accession Description Interval E-value
VWC smart00214
von Willebrand factor (vWF) type C domain;
752-824 1.30e-08

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 52.52  E-value: 1.30e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442617837    752 CTFKGAEYDVGQQFRDGCDQLCICNEQG-IHCAKLECPSNfgldvqdPHCIRWEPVPAdfkpsPPNCCPesmRC 824
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPP-------PDCPNPERVKP-----PGECCP---RC 59
fn3 pfam00041
Fibronectin type III domain;
1068-1134 1.53e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.53e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442617837  1068 LTVSETNASWLQLTWKKLGDDQMEyVDGVQLRYKELTGMIYSSTPLIHRTLTSYTIQNLQPDTGYEI 1134
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGNGP-ITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEV 71
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1171-1260 4.09e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.34  E-value: 4.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617837 1171 VNVTKVKTQSVEISWNGVPYPEDKFVHiYRaIYQSDAGKEDSSVFKVAKRDSTTgTLIMDLKPGTKYRLWLEMYLTNGNT 1250
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEDDGGPITG-YV-VEYREKGSGDWKEVEVTPGSETS-YTLTGLKPGTEYEFRVRAVNGGGES 83

                          90
                  ....*....|
gi 442617837 1251 KKSNVVNFIT 1260
Cdd:cd00063    84 PPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1066-1145 5.10e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 5.10e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617837   1066 PELTVSETNASWLQLTWKK-LGDDQMEYVDGVQLRYKELTGMiySSTPLIHRTLTSYTIQNLQPDTGYEIGLYYIPLAGH 1144
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82


                    .
gi 442617837   1145 G 1145
Cdd:smart00060   83 G 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1068-1146 8.51e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 8.51e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442617837 1068 LTVSETNASWLQLTWKKLGDDQMEyVDGVQLRYKELTGMIYSSTPLIHRTLTSYTIQNLQPDTGYEIGLYYIPLAGHGA 1146
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPPEDDGGP-ITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1171-1241 7.45e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.60  E-value: 7.45e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442617837   1171 VNVTKVKTQSVEISWNGvpyPEDKFVHIYRAIYQSDAGKEDSSVFKVAKRDSTTGTLIMDLKPGTKYRLWL 1241
Cdd:smart00060    7 LRVTDVTSTSVTLSWEP---PPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
fn3 pfam00041
Fibronectin type III domain;
1171-1253 2.94e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.86  E-value: 2.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617837  1171 VNVTKVKTQSVEISWNGVPYPEDKFVHiYRAIYQSDAGKEDSSVFKVAKrdSTTGTLIMDLKPGTKYRLWLEMYLTNGNT 1250
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGNGPITG-YEVEYRPKNSGEPWNEITVPG--TTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 442617837  1251 KKS 1253
Cdd:pfam00041   83 PPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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