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Conserved domains on  [gi|442619754|ref|NP_001262696|]
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cadmus, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Importin_rep_3 pfam18806
Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in ...
 838-912 2.00e-28

Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in cargo substrates. It mediates docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


:

Pssm-ID: 465873  Cd Length: 75  Bit Score: 108.73  E-value: 2.00e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442619754  838 MTLPESGAIRNSIQFLTHFVMQSRNHAHVTEVVLATGEQTLYTAMMCVGYLTPRSQVDKFADILLAMNRKYAAEM 912
Cdd:pfam18806   1 LTLPERPTVKAACSFLTEFISQSREHPALKQVVQAYGELLVRTILLGIGGGSPRSLVENLADVLLALNKKYPEEL 75
Importin_rep super family cl40074
Importin 13 repeat; Importin 13 has a spiralic structure containing repeats structurally ...
 418-454 1.00e-14

Importin 13 repeat; Importin 13 has a spiralic structure containing repeats structurally similar to HEAT repeats. It serves as receptor for nuclear localization signals (NLS) in cargo substrates, mediating docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


The actual alignment was detected with superfamily member pfam18773:

Pssm-ID: 436727  Cd Length: 40  Bit Score: 68.93  E-value: 1.00e-14
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442619754  418 PDEKSLAKWSSDDLECFRCYRQDISDTFMYCYDVLND 454
Cdd:pfam18773   3 PSDEEYNSWSADEKEQFRCYRQDISDTLMYSYNILHE 39
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 29-93 7.84e-14

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


:

Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 66.88  E-value: 7.84e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442619754    29 EWLTDAEASPQAWQFSWQLMQLGKSQEVQFFGAITLHSKLMKHWHEVPPENREELKQKILESIVR 93
Cdd:smart00913   3 KQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
Xpo1 super family cl37774
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 98-220 7.56e-05

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


The actual alignment was detected with superfamily member pfam08389:

Pssm-ID: 462459  Cd Length: 147  Bit Score: 43.75  E-value: 7.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619754   98 PKIVLNRLCISLGAYIVHMLGE-WPGAIEEVINTFQNQrmpnvsaDVQLWIMLEVLTAIPEEAQVI----HTSVKRVVLR 172
Cdd:pfam08389   1 PKFIRNKLALALAELAKQEYPNnWPTFFPDLISLLSSN-------PTGCELFLRILKVLPEEIFDFsrtsLTQDRNNRLK 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 442619754  173 AEIAKRVQLVIHTVERYLKLQMNrvwdaeAYSNMNRAV-KCVGTWIKNI 220
Cdd:pfam08389  74 DLLRSNMEQILELLLQILEASQN------ANSELVEAVlKCLGSWLSWI 116
 
Name Accession Description Interval E-value
Importin_rep_3 pfam18806
Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in ...
 838-912 2.00e-28

Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in cargo substrates. It mediates docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


Pssm-ID: 465873  Cd Length: 75  Bit Score: 108.73  E-value: 2.00e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442619754  838 MTLPESGAIRNSIQFLTHFVMQSRNHAHVTEVVLATGEQTLYTAMMCVGYLTPRSQVDKFADILLAMNRKYAAEM 912
Cdd:pfam18806   1 LTLPERPTVKAACSFLTEFISQSREHPALKQVVQAYGELLVRTILLGIGGGSPRSLVENLADVLLALNKKYPEEL 75
Importin_rep pfam18773
Importin 13 repeat; Importin 13 has a spiralic structure containing repeats structurally ...
 418-454 1.00e-14

Importin 13 repeat; Importin 13 has a spiralic structure containing repeats structurally similar to HEAT repeats. It serves as receptor for nuclear localization signals (NLS) in cargo substrates, mediating docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


Pssm-ID: 436727  Cd Length: 40  Bit Score: 68.93  E-value: 1.00e-14
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442619754  418 PDEKSLAKWSSDDLECFRCYRQDISDTFMYCYDVLND 454
Cdd:pfam18773   3 PSDEEYNSWSADEKEQFRCYRQDISDTLMYSYNILHE 39
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 29-93 7.84e-14

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 66.88  E-value: 7.84e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442619754    29 EWLTDAEASPQAWQFSWQLMQLGKSQEVQFFGAITLHSKLMKHWHEVPPENREELKQKILESIVR 93
Cdd:smart00913   3 KQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
IBN_N pfam03810
Importin-beta N-terminal domain;
28-92 7.60e-11

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 58.79  E-value: 7.60e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619754   28 HEWLTDAEASPQAWQFSWQLMQLGKSQ-EVQFFGAITLHSKLMKHWHE----VPPENREELKQKILESIV 92
Cdd:pfam03810   2 EKQLEQFEKSPGFWSKLLQILSNSENPlEVRQLAALYLKNLITRHWEEeknsLPPEEKEQIKNNLLNLLG 71
CRM1 COG5101
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ...
 4-132 6.00e-05

Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];


Pssm-ID: 227432 [Multi-domain]  Cd Length: 1053  Bit Score: 47.24  E-value: 6.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619754    4 IDIARLEEAVVSFYRSNSQNQAITHEWLTDAEASPQAWQFSWQLMQLGKSQEVQFFGAITLHSKLMKHWHEVPPENREEL 83
Cdd:COG5101    11 LDIALLDKVVTTFYQGDGRKQEQAQRILTKFQELPDAWTKADYILNNSKLPQSKYIALSLLDKLITTKWKLLPEGMRQGI 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619754   84 KQKILESIVRFAGGPKI------VLNRLCISLgayiVHMLGE-----WPGAIEEVINTFQ 132
Cdd:COG5101    91 RNYVVQLVIEKSQDDKVrdkqkyVLNKLDLTL----VQILKQewprnWPTFIPELINVSQ 146
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 98-220 7.56e-05

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


Pssm-ID: 462459  Cd Length: 147  Bit Score: 43.75  E-value: 7.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619754   98 PKIVLNRLCISLGAYIVHMLGE-WPGAIEEVINTFQNQrmpnvsaDVQLWIMLEVLTAIPEEAQVI----HTSVKRVVLR 172
Cdd:pfam08389   1 PKFIRNKLALALAELAKQEYPNnWPTFFPDLISLLSSN-------PTGCELFLRILKVLPEEIFDFsrtsLTQDRNNRLK 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 442619754  173 AEIAKRVQLVIHTVERYLKLQMNrvwdaeAYSNMNRAV-KCVGTWIKNI 220
Cdd:pfam08389  74 DLLRSNMEQILELLLQILEASQN------ANSELVEAVlKCLGSWLSWI 116
 
Name Accession Description Interval E-value
Importin_rep_3 pfam18806
Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in ...
 838-912 2.00e-28

Importin 13 repeat; Importin 13 serves as receptor for nuclear localization signals (NLS) in cargo substrates. It mediates docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


Pssm-ID: 465873  Cd Length: 75  Bit Score: 108.73  E-value: 2.00e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442619754  838 MTLPESGAIRNSIQFLTHFVMQSRNHAHVTEVVLATGEQTLYTAMMCVGYLTPRSQVDKFADILLAMNRKYAAEM 912
Cdd:pfam18806   1 LTLPERPTVKAACSFLTEFISQSREHPALKQVVQAYGELLVRTILLGIGGGSPRSLVENLADVLLALNKKYPEEL 75
Importin_rep pfam18773
Importin 13 repeat; Importin 13 has a spiralic structure containing repeats structurally ...
 418-454 1.00e-14

Importin 13 repeat; Importin 13 has a spiralic structure containing repeats structurally similar to HEAT repeats. It serves as receptor for nuclear localization signals (NLS) in cargo substrates, mediating docking of the importin/substrate complex to the nuclear pore complex (NPC). It contains several repeats structurally similar to the HEAT repeat. This Pfam entry represents a single repeat unit.


Pssm-ID: 436727  Cd Length: 40  Bit Score: 68.93  E-value: 1.00e-14
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442619754  418 PDEKSLAKWSSDDLECFRCYRQDISDTFMYCYDVLND 454
Cdd:pfam18773   3 PSDEEYNSWSADEKEQFRCYRQDISDTLMYSYNILHE 39
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 29-93 7.84e-14

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 66.88  E-value: 7.84e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442619754    29 EWLTDAEASPQAWQFSWQLMQLGKSQEVQFFGAITLHSKLMKHWHEVPPENREELKQKILESIVR 93
Cdd:smart00913   3 KQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
IBN_N pfam03810
Importin-beta N-terminal domain;
28-92 7.60e-11

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 58.79  E-value: 7.60e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619754   28 HEWLTDAEASPQAWQFSWQLMQLGKSQ-EVQFFGAITLHSKLMKHWHE----VPPENREELKQKILESIV 92
Cdd:pfam03810   2 EKQLEQFEKSPGFWSKLLQILSNSENPlEVRQLAALYLKNLITRHWEEeknsLPPEEKEQIKNNLLNLLG 71
CRM1 COG5101
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ...
 4-132 6.00e-05

Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];


Pssm-ID: 227432 [Multi-domain]  Cd Length: 1053  Bit Score: 47.24  E-value: 6.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619754    4 IDIARLEEAVVSFYRSNSQNQAITHEWLTDAEASPQAWQFSWQLMQLGKSQEVQFFGAITLHSKLMKHWHEVPPENREEL 83
Cdd:COG5101    11 LDIALLDKVVTTFYQGDGRKQEQAQRILTKFQELPDAWTKADYILNNSKLPQSKYIALSLLDKLITTKWKLLPEGMRQGI 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619754   84 KQKILESIVRFAGGPKI------VLNRLCISLgayiVHMLGE-----WPGAIEEVINTFQ 132
Cdd:COG5101    91 RNYVVQLVIEKSQDDKVrdkqkyVLNKLDLTL----VQILKQewprnWPTFIPELINVSQ 146
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 98-220 7.56e-05

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


Pssm-ID: 462459  Cd Length: 147  Bit Score: 43.75  E-value: 7.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442619754   98 PKIVLNRLCISLGAYIVHMLGE-WPGAIEEVINTFQNQrmpnvsaDVQLWIMLEVLTAIPEEAQVI----HTSVKRVVLR 172
Cdd:pfam08389   1 PKFIRNKLALALAELAKQEYPNnWPTFFPDLISLLSSN-------PTGCELFLRILKVLPEEIFDFsrtsLTQDRNNRLK 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 442619754  173 AEIAKRVQLVIHTVERYLKLQMNrvwdaeAYSNMNRAV-KCVGTWIKNI 220
Cdd:pfam08389  74 DLLRSNMEQILELLLQILEASQN------ANSELVEAVlKCLGSWLSWI 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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