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Conserved domains on  [gi|442621193|ref|NP_001262973|]
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lipophorin receptor 1, isoform Q [Drosophila melanogaster]

Protein Classification

LDL receptor domain-containing protein( domain architecture ID 11257860)

Low Density Lipoprotein (LDL) receptor class A domain is a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; similar to Bos taurus CD320 antigen

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 663-706 2.11e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 64.93  E-value: 2.11e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 442621193   663 KVLVKDSLDIPRSIALDPIEGWMYWSDWGaSPRIERAGMDGSHR 706
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 708-749 1.25e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.25e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 442621193   708 TIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQR 749
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 178-210 3.23e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.80  E-value: 3.23e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442621193   178 TCSSDQFRCGNGNCIPNKWRCDQESDCADGSDE 210
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
382-418 3.49e-10

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.72  E-value: 3.49e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442621193  382 VTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDC 418
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 135-167 3.16e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 3.16e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442621193   135 KCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDE 167
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 219-254 4.02e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 4.02e-09
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 442621193 219 CPNNEFKCQTvDQCIPRSWLCDGSNDCRDKSDEAHC 254
Cdd:cd00112    1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 302-332 4.44e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 4.44e-09
                         10        20        30
                 ....*....|....*....|....*....|.
gi 442621193 302 EHTCTNGACIAKRWVCDGDPDCSDGSDERSC 332
Cdd:cd00112    5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 473-508 1.90e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 1.90e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442621193  473 CASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNC 508
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 435-463 9.52e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.09  E-value: 9.52e-07
                           10        20
                   ....*....|....*....|....*....
gi 442621193   435 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 463
Cdd:smart00192   5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 342-374 1.31e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 1.31e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442621193   342 CLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDE 374
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 621-661 5.60e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 5.60e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 442621193   621 VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSM 661
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
510-540 3.57e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 3.57e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442621193   510 DINECEVPGKCSQ--ICVNEIGGFKCECEAGYM 540
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 823-864 5.65e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.07  E-value: 5.65e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 442621193  823 CQSVNGHCSHLCLPAPRinerspRISCACPTGLKLMVDGLMC 864
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 728-774 5.40e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.60  E-value: 5.40e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 442621193  728 RIYWVDGKL-NVISSANYDGSQRSQVLySGEyLRHPFSITtfednVYW 774
Cdd:pfam00058   2 RLYWTDSSLrASISSADLNGSDRKTLF-TDD-LQHPNAIA-----VDP 42
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 663-706 2.11e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 64.93  E-value: 2.11e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 442621193   663 KVLVKDSLDIPRSIALDPIEGWMYWSDWGaSPRIERAGMDGSHR 706
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 708-749 1.25e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.25e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 442621193   708 TIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQR 749
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 685-723 2.89e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 59.10  E-value: 2.89e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442621193  685 MYWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLD 723
Cdd:pfam00058   3 LYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 178-210 3.23e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.80  E-value: 3.23e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442621193   178 TCSSDQFRCGNGNCIPNKWRCDQESDCADGSDE 210
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 179-212 7.03e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 7.03e-11
                         10        20        30
                 ....*....|....*....|....*....|....
gi 442621193 179 CSSDQFRCGNGNCIPNKWRCDQESDCADGSDEAN 212
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
178-212 1.68e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.68e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 442621193  178 TCSSDQFRCGNGNCIPNKWRCDQESDCADGSDEAN 212
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
382-418 3.49e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.72  E-value: 3.49e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442621193  382 VTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDC 418
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 384-418 3.59e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 3.59e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 442621193 384 CRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDC 418
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 135-167 3.16e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 3.16e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442621193   135 KCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDE 167
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 219-254 4.02e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 4.02e-09
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 442621193 219 CPNNEFKCQTvDQCIPRSWLCDGSNDCRDKSDEAHC 254
Cdd:cd00112    1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 302-332 4.44e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 4.44e-09
                         10        20        30
                 ....*....|....*....|....*....|.
gi 442621193 302 EHTCTNGACIAKRWVCDGDPDCSDGSDERSC 332
Cdd:cd00112    5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 136-168 4.44e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 4.44e-09
                         10        20        30
                 ....*....|....*....|....*....|...
gi 442621193 136 CDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQ 168
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 383-415 4.91e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 4.91e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442621193   383 TCRADQFQCGDRSCIPGHLTCNGDKDCADGSDE 415
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 473-508 1.90e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 1.90e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442621193  473 CASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNC 508
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
219-254 1.93e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 1.93e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442621193  219 CPNNEFKCQTvDQCIPRSWLCDGSNDCRDKSDEAHC 254
Cdd:pfam00057   3 CSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
135-168 2.17e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 2.17e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 442621193  135 KCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQ 168
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
301-332 2.71e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 2.71e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 442621193  301 AEHTCTNGACIAKRWVCDGDPDCSDGSDERSC 332
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 302-329 5.45e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 5.45e-08
                           10        20
                   ....*....|....*....|....*...
gi 442621193   302 EHTCTNGACIAKRWVCDGDPDCSDGSDE 329
Cdd:smart00192   6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 219-251 1.58e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.01  E-value: 1.58e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442621193   219 CPNNEFKCQTvDQCIPRSWLCDGSNDCRDKSDE 251
Cdd:smart00192   2 CPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 435-463 9.52e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.09  E-value: 9.52e-07
                           10        20
                   ....*....|....*....|....*....
gi 442621193   435 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 463
Cdd:smart00192   5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 435-463 1.07e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 1.07e-06
                         10        20
                 ....*....|....*....|....*....
gi 442621193 435 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 463
Cdd:cd00112    4 NEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 342-374 1.31e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 1.31e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442621193   342 CLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDE 374
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 342-374 1.61e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.28  E-value: 1.61e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 442621193 342 CLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDE 374
Cdd:cd00112    1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 621-661 5.60e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 5.60e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 442621193   621 VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSM 661
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
340-379 1.08e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.01  E-value: 1.08e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 442621193  340 TPCLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDEhtANC 379
Cdd:pfam00057   1 STCSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDE--ENC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
510-540 3.57e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 3.57e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442621193   510 DINECEVPGKCSQ--ICVNEIGGFKCECEAGYM 540
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 823-864 5.65e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.07  E-value: 5.65e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 442621193  823 CQSVNGHCSHLCLPAPRinerspRISCACPTGLKLMVDGLMC 864
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 510-540 1.30e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.30e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 442621193 510 DINECEVPGKCS--QICVNEIGGFKCECEAGYM 540
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
435-463 1.58e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.92  E-value: 1.58e-04
                          10        20
                  ....*....|....*....|....*....
gi 442621193  435 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 463
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA pfam07645
Calcium-binding EGF domain;
510-538 1.68e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 1.68e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 442621193  510 DINECEVPGK-CSQ--ICVNEIGGFKCECEAG 538
Cdd:pfam07645   1 DVDECATGTHnCPAntVCVNTIGSFECRCPDG 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 728-774 5.40e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.60  E-value: 5.40e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 442621193  728 RIYWVDGKL-NVISSANYDGSQRSQVLySGEyLRHPFSITtfednVYW 774
Cdd:pfam00058   2 RLYWTDSSLrASISSADLNGSDRKTLF-TDD-LQHPNAIA-----VDP 42
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 663-706 2.11e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 64.93  E-value: 2.11e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 442621193   663 KVLVKDSLDIPRSIALDPIEGWMYWSDWGaSPRIERAGMDGSHR 706
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 708-749 1.25e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.25e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 442621193   708 TIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQR 749
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 685-723 2.89e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 59.10  E-value: 2.89e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442621193  685 MYWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLD 723
Cdd:pfam00058   3 LYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 178-210 3.23e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.80  E-value: 3.23e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442621193   178 TCSSDQFRCGNGNCIPNKWRCDQESDCADGSDE 210
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 179-212 7.03e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.60  E-value: 7.03e-11
                         10        20        30
                 ....*....|....*....|....*....|....
gi 442621193 179 CSSDQFRCGNGNCIPNKWRCDQESDCADGSDEAN 212
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEEN 34
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
178-212 1.68e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.87  E-value: 1.68e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 442621193  178 TCSSDQFRCGNGNCIPNKWRCDQESDCADGSDEAN 212
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
382-418 3.49e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.72  E-value: 3.49e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442621193  382 VTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDC 418
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 384-418 3.59e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.68  E-value: 3.59e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 442621193 384 CRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDC 418
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 135-167 3.16e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.02  E-value: 3.16e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442621193   135 KCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDE 167
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 219-254 4.02e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 4.02e-09
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 442621193 219 CPNNEFKCQTvDQCIPRSWLCDGSNDCRDKSDEAHC 254
Cdd:cd00112    1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 302-332 4.44e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 4.44e-09
                         10        20        30
                 ....*....|....*....|....*....|.
gi 442621193 302 EHTCTNGACIAKRWVCDGDPDCSDGSDERSC 332
Cdd:cd00112    5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 136-168 4.44e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.59  E-value: 4.44e-09
                         10        20        30
                 ....*....|....*....|....*....|...
gi 442621193 136 CDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQ 168
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 383-415 4.91e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.64  E-value: 4.91e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442621193   383 TCRADQFQCGDRSCIPGHLTCNGDKDCADGSDE 415
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 473-508 1.90e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 1.90e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442621193  473 CASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNC 508
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
219-254 1.93e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 1.93e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442621193  219 CPNNEFKCQTvDQCIPRSWLCDGSNDCRDKSDEAHC 254
Cdd:pfam00057   3 CSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
135-168 2.17e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 2.17e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 442621193  135 KCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQ 168
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
301-332 2.71e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.32  E-value: 2.71e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 442621193  301 AEHTCTNGACIAKRWVCDGDPDCSDGSDERSC 332
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 302-329 5.45e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 5.45e-08
                           10        20
                   ....*....|....*....|....*...
gi 442621193   302 EHTCTNGACIAKRWVCDGDPDCSDGSDE 329
Cdd:smart00192   6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 219-251 1.58e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.01  E-value: 1.58e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442621193   219 CPNNEFKCQTvDQCIPRSWLCDGSNDCRDKSDE 251
Cdd:smart00192   2 CPPGEFQCDN-GRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 435-463 9.52e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.09  E-value: 9.52e-07
                           10        20
                   ....*....|....*....|....*....
gi 442621193   435 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 463
Cdd:smart00192   5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 435-463 1.07e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 1.07e-06
                         10        20
                 ....*....|....*....|....*....
gi 442621193 435 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 463
Cdd:cd00112    4 NEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 342-374 1.31e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.70  E-value: 1.31e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442621193   342 CLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDE 374
Cdd:smart00192   2 CPPGEFQCDNG-RCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 342-374 1.61e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 45.28  E-value: 1.61e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 442621193 342 CLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDE 374
Cdd:cd00112    1 CPPNEFRCANG-RCIPSSWVCDGEDDCGDGSDE 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 621-661 5.60e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 5.60e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 442621193   621 VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSM 661
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
340-379 1.08e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 43.01  E-value: 1.08e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 442621193  340 TPCLSHEYQCKDRiTCLHHSWLCDGDRDCPDGDDEhtANC 379
Cdd:pfam00057   1 STCSPNEFQCGSG-ECIPRSWVCDGDPDCGDGSDE--ENC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
510-540 3.57e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 3.57e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442621193   510 DINECEVPGKCSQ--ICVNEIGGFKCECEAGYM 540
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 823-864 5.65e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.07  E-value: 5.65e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 442621193  823 CQSVNGHCSHLCLPAPRinerspRISCACPTGLKLMVDGLMC 864
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 492-513 7.02e-05

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 40.47  E-value: 7.02e-05
                          10        20
                  ....*....|....*....|..
gi 442621193  492 HCECHEGYKLSPDKRNCQDINE 513
Cdd:pfam12662   1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 510-540 1.30e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.30e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 442621193 510 DINECEVPGKCS--QICVNEIGGFKCECEAGYM 540
Cdd:cd00054    1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
435-463 1.58e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.92  E-value: 1.58e-04
                          10        20
                  ....*....|....*....|....*....
gi 442621193  435 SEFDCGGGQCVPLSKVCDKRKDCPDGEDE 463
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA pfam07645
Calcium-binding EGF domain;
510-538 1.68e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 1.68e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 442621193  510 DINECEVPGK-CSQ--ICVNEIGGFKCECEAG 538
Cdd:pfam07645   1 DVDECATGTHnCPAntVCVNTIGSFECRCPDG 32
PRKCSH-like pfam12999
Glucosidase II beta subunit-like; The sequences found in this family are similar to a region ...
 137-219 4.97e-03

Glucosidase II beta subunit-like; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum.


Pssm-ID: 372423 [Multi-domain]  Cd Length: 176  Bit Score: 39.00  E-value: 4.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621193  137 DEK-QFQCHSGDCIPIRF--VCDGDADCKDHSDEQIKeckfieATCSSDQFRCGNGNCIP--------NKWRCDQESdCA 205
Cdd:pfam12999  33 DENgNWKCLNHSEIKLSFdqVNDDYCDCPDGSDEPGT------NACSNGKFYCANEGFIPgyipsfkvDDGVCDYDI-CC 105

                          90
                  ....*....|....
gi 442621193  206 DGSDEANELCMNAC 219
Cdd:pfam12999 106 DGSDEALGKCPNKC 119
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 728-774 5.40e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.60  E-value: 5.40e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 442621193  728 RIYWVDGKL-NVISSANYDGSQRSQVLySGEyLRHPFSITtfednVYW 774
Cdd:pfam00058   2 RLYWTDSSLrASISSADLNGSDRKTLF-TDD-LQHPNAIA-----VDP 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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