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Conserved domains on  [gi|442621203|ref|NP_001262977|]
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tetraspanin 96F, isoform C [Drosophila melanogaster]

Protein Classification

tetraspanin family protein( domain architecture ID 13626497)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0005886
PubMed:  15763890|11756464|19709882|16024509
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 107-233 3.35e-34

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


:

Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 119.37  E-value: 3.35e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203 107 FHNKDKLDDIVRAAVKSSVQEEYGQSTMSSRTVTFDTLQKNLKCCGADGPGDWATSRFNNvdrtniveiavSSMNVFYNI 186
Cdd:cd03155    1 YTYYQQLEDELKESLKRTMQENYGQSGEEALTLTVDELQQEFKCCGSNNYTDWQDSEWIN-----------SNEANGRLV 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 442621203 187 PESCCKDNLKDNECElsrrlkfgGPLNNAIYQ--QGCVDKLIEIIYENW 233
Cdd:cd03155   70 PDSCCKTVVDRCGCL--------RDHPSNIYKveGGCIPKLEDFLYDHL 110
Tetraspanin pfam00335
Tetraspanin family;
10-259 4.13e-32

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 116.65  E-value: 4.13e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203   10 VKYLMVLINILFWLIGLTIVVTSVWMLTDPTFMLSMTQNYNHYhiALYVFLAIGILITLGAFFGCCGVCRESQCLLVSFF 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAY--IPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203   90 CVILIVMVAQIAAGAWAFHNKDKLDDIVRAAVKSSVQEEYGQSTMSSRTVT--FDTLQKNLKCCGadgpgdwatsrfnnv 167
Cdd:pfam00335  79 VLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLYSCLNsaLDSLQSEFGCCG--------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203  168 drtniveiavssmnvfynipescckdnlkdnecelsrrlkfggplnnaiyqqGCVDKLIEIIYENWVTIFAVTAAVILLE 247
Cdd:pfam00335 144 ----------------------------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQ 171

                         250
                  ....*....|..
gi 442621203  248 LLSLTFALSLCC 259
Cdd:pfam00335 172 LLGIILACCLCC 183
 
Name Accession Description Interval E-value
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 107-233 3.35e-34

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 119.37  E-value: 3.35e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203 107 FHNKDKLDDIVRAAVKSSVQEEYGQSTMSSRTVTFDTLQKNLKCCGADGPGDWATSRFNNvdrtniveiavSSMNVFYNI 186
Cdd:cd03155    1 YTYYQQLEDELKESLKRTMQENYGQSGEEALTLTVDELQQEFKCCGSNNYTDWQDSEWIN-----------SNEANGRLV 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 442621203 187 PESCCKDNLKDNECElsrrlkfgGPLNNAIYQ--QGCVDKLIEIIYENW 233
Cdd:cd03155   70 PDSCCKTVVDRCGCL--------RDHPSNIYKveGGCIPKLEDFLYDHL 110
Tetraspanin pfam00335
Tetraspanin family;
10-259 4.13e-32

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 116.65  E-value: 4.13e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203   10 VKYLMVLINILFWLIGLTIVVTSVWMLTDPTFMLSMTQNYNHYhiALYVFLAIGILITLGAFFGCCGVCRESQCLLVSFF 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAY--IPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203   90 CVILIVMVAQIAAGAWAFHNKDKLDDIVRAAVKSSVQEEYGQSTMSSRTVT--FDTLQKNLKCCGadgpgdwatsrfnnv 167
Cdd:pfam00335  79 VLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLYSCLNsaLDSLQSEFGCCG--------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203  168 drtniveiavssmnvfynipescckdnlkdnecelsrrlkfggplnnaiyqqGCVDKLIEIIYENWVTIFAVTAAVILLE 247
Cdd:pfam00335 144 ----------------------------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQ 171

                         250
                  ....*....|..
gi 442621203  248 LLSLTFALSLCC 259
Cdd:pfam00335 172 LLGIILACCLCC 183
 
Name Accession Description Interval E-value
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 107-233 3.35e-34

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 119.37  E-value: 3.35e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203 107 FHNKDKLDDIVRAAVKSSVQEEYGQSTMSSRTVTFDTLQKNLKCCGADGPGDWATSRFNNvdrtniveiavSSMNVFYNI 186
Cdd:cd03155    1 YTYYQQLEDELKESLKRTMQENYGQSGEEALTLTVDELQQEFKCCGSNNYTDWQDSEWIN-----------SNEANGRLV 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 442621203 187 PESCCKDNLKDNECElsrrlkfgGPLNNAIYQ--QGCVDKLIEIIYENW 233
Cdd:cd03155   70 PDSCCKTVVDRCGCL--------RDHPSNIYKveGGCIPKLEDFLYDHL 110
Tetraspanin pfam00335
Tetraspanin family;
10-259 4.13e-32

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 116.65  E-value: 4.13e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203   10 VKYLMVLINILFWLIGLTIVVTSVWMLTDPTFMLSMTQNYNHYhiALYVFLAIGILITLGAFFGCCGVCRESQCLLVSFF 89
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAY--IPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203   90 CVILIVMVAQIAAGAWAFHNKDKLDDIVRAAVKSSVQEEYGQSTMSSRTVT--FDTLQKNLKCCGadgpgdwatsrfnnv 167
Cdd:pfam00335  79 VLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLYSCLNsaLDSLQSEFGCCG--------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203  168 drtniveiavssmnvfynipescckdnlkdnecelsrrlkfggplnnaiyqqGCVDKLIEIIYENWVTIFAVTAAVILLE 247
Cdd:pfam00335 144 ----------------------------------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQ 171

                         250
                  ....*....|..
gi 442621203  248 LLSLTFALSLCC 259
Cdd:pfam00335 172 LLGIILACCLCC 183
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 110-232 1.94e-12

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 62.55  E-value: 1.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203 110 KDKLDDIVRAAVKSSVQEEYgqSTMSSRTVTFDTLQKNLKCCGADGPGDW--ATSRFNNVDRTNiveiavssmnvfYNIP 187
Cdd:cd03156    6 KKDLEDSFKNLLKNNYGNYN--STGDAITSTWNRVMIELKCCGVNGPTDFvdSTSFFRQKNEPN------------SPYP 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 442621203 188 ESCCKDNLKDNECELSRRlKFGGPlnNAIYQQGCVDKLIEIIYEN 232
Cdd:cd03156   72 ESCCKRNSNSQIVDLDCP-KLGSP--NSYNKKGCYEKLSNPIERY 113
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 107-232 6.58e-12

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 60.21  E-value: 6.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203 107 FHNKDKLDDIVRAAVKSSVQEEYGQSTMSSrtvTFDTLQKNLKCCGADGPGDWATSRfnnvdRTniveiavssmnvfynI 186
Cdd:cd03127    1 FVYRDQLESLVSDTLNDAWDEYYVDDDFQE---AMDALQSTFECCGVNGPTDYLDLR-----LL---------------V 57

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 442621203 187 PESCCKDNLKDNECElsrrlkfggplnnaIYQQGCVDKLIEIIYEN 232
Cdd:cd03127   58 PSSCCKGTDGNCGLN--------------LYTEGCLEKLVDFLRSN 89
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 109-225 2.95e-10

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 56.62  E-value: 2.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203 109 NKDKLDDIVRAAVKSSVQEEYGQSTMSSRTVTFDTLQKNLKCCGADGPGDWatsrFNNVDRTNiveiavSSMNVFyniPE 188
Cdd:cd03160    4 QRDKLKQEMGDIVEKVIQNYGGNPENKTAEEAWDYVQFQLQCCGWTGPQDW----TDNSLIKN------SSEPLY---PC 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 442621203 189 SCCKDNLKDNE-------CELsrrlkfGGPLNNAIYQQGCVDKL 225
Cdd:cd03160   71 SCCNSSATADSprpskgfCEA------PASLDWPVYQEGCMEKL 108
TM4SF9_like_LEL cd03159
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. ...
 142-222 7.37e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 9 (TM4SF9) or Tetraspanin-5 and related proteins. TM4SF9 is strongly expressed witin the central nervous system, and expression levels appear to correlate with differentiation status of particular neurons, hinting at a role in neuronal maturation.


Pssm-ID: 239412 [Multi-domain]  Cd Length: 121  Bit Score: 49.73  E-value: 7.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203 142 DTLQKNLKCCGADGPGDWATSRFNNVDRTNIVEIAVSsmnvfynIPESCC-KDNLKD---NECELSRRLKFGGPLNNAIY 217
Cdd:cd03159   33 DFLQEYWQCCGARGPDDWNLNIYFNCTDSNPSRERCG-------VPFSCCvKDPAEDvvnTQCGYDVRKKPELELQHHIH 105


                 ....*
gi 442621203 218 QQGCV 222
Cdd:cd03159  106 TKGCV 110
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 110-232 9.14e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 46.31  E-value: 9.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203 110 KDKLDDIVRAAVKSSVQeeyGQSTMSSRTVTFDTLQKNLKCCGADGPGDWATSRFNNVDRtniveiavssmnvfynIPES 189
Cdd:cd03166    4 RDKVMSEFNDSFNQMIS---NYNKTNDFRKILDRMQKDLKCCGANNYTDWENIPSLDTDS----------------VPDS 64

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 442621203 190 CCKDNLKDneCELSRRLKfggplnnAIYQQGCVDKLIEIIYEN 232
Cdd:cd03166   65 CCINVTKG--CGINFDEK-------VIHLEGCVTKIEGWLKKN 98
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 110-231 3.83e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 44.72  E-value: 3.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203 110 KDKLDDIVRAAVKSsVQEEYGQSTMSSRTVtfDTLQKNLKCCGADGPGDWATSRFNNvdrtniveiavSSMNvfYNIPES 189
Cdd:cd03163    5 RAKVEDELNPSIDK-VFNKYNGTNAESRAV--DYLQRQLQCCGIHNYTDWENTPWFK-----------ESKN--NSVPLS 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 442621203 190 CCKDNLKDneCelSRRLKFGGPLnnaiYQQGCVDKLIEIIYE 231
Cdd:cd03163   69 CCKETFTS--C--TGSLTQPKDL----YQEGCEAKLVKKLQE 102
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 110-232 1.32e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 43.12  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203 110 KDKLDDIVRAAVKSsvqeeYGQSTMSSRTVtfDTLQKNLKCCGADGPGDWATSrfnnvdrtniveiavssmNVFYN--IP 187
Cdd:cd03161    8 KGTFLRTYNEAVSN-----YNGDDERSDAV--DTVQRTLHCCGVENYTDWLNS------------------PYFLEkgIP 62

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 442621203 188 ESCCKDNlkdNECELsRRLKFGGPLNNAIYQQGCVDKLIEIIYEN 232
Cdd:cd03161   63 LSCCKNR---SDCSP-QDLKNLTKAATKVYQQGCFTLVTSFMEAN 103
TM4SF3_like_LEL cd03154
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. ...
 141-232 1.91e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 3 (TM4SF3) or D6.1a and related proteins. D6.1a associates with alpha6beta4 integrin and supports cell motility, it has been ascribed a role in tumor progression and metastasis.


Pssm-ID: 239407 [Multi-domain]  Cd Length: 100  Bit Score: 37.02  E-value: 1.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203 141 FDTLQKNLKCCGADGPGDWATSrfnnvdrtniveiavssmnvfyNIPESC-CkdNLKDNECELSRrlkFGGplnNAIYQQ 219
Cdd:cd03154   37 LEKFQKELKCCGLVNGADDWGN----------------------DIPASCnC--TTTQSDCVVAY---YGG---SNVYKE 86

                         90
                 ....*....|...
gi 442621203 220 GCVDKLIEIIYEN 232
Cdd:cd03154   87 PCISKIKDFLKKN 99
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 129-235 2.89e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 36.19  E-value: 2.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442621203 129 YGQSTMSSRTVTFDTLQKNLKCCGADGPGDWatsrfNNVDRTNIVeiavssmnvfyniPESCCKDNLKDneCELSRrlkf 208
Cdd:cd03165   22 YGTRNNRGLTNAWDITQTEFRCCGVTNYTDW-----YEVLGENRV-------------PDSCCQEDSQD--CGRNP---- 77

                         90       100
                 ....*....|....*....|....*..
gi 442621203 209 ggplNNAIYQQGCVDKLieiiyENWVT 235
Cdd:cd03165   78 ----TELWWKTGCYEKV-----QQWLV 95
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 112-159 5.02e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 35.53  E-value: 5.02e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 442621203 112 KLDDIVRAAVKSSVQEEYGQStmsSRTVTFDTLQKNLKCCGADGPGDW 159
Cdd:cd03164    6 KLNNYVKEGLTDSLEQYHKDN---NTSEAWDMIQSNLQCCGINGTTDW 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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