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Conserved domains on  [gi|453232062|ref|NP_001263734|]
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Coronin-7 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 599-1029 1.44e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 145.42  E-value: 1.44e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  599 SKFRHVDGQQGtKSGAVFSNLrNVNTRLPPESNGVCCSNKFAAVPLAGLGVIGIYDVNEPGKLPDGVMDGIFNKTLVTDL 678
Cdd:PTZ00421    4 SRFRHTQGVPA-RPDRHFLNV-TPSTALWDCSNTIACNDRFIAVPWQQLGSTAVLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  679 HWNPFDDEQLAVGTDCGQINLWRLTTNDGPRNEMEPekIIKIGG--EKITSLRWHPLASDLLAVALSNSTIELWDVANAK 756
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDP--IVHLQGhtKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  757 LYSRFVNHTGGILGIAWSADGRRIASVGKDATLFVHEPasREQRVYERKTVVESTRAARVLFACDDRIVIVVGMTKSSQR 836
Cdd:PTZ00421  160 AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDP--RDGTIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQR 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  837 QVQMYDAQtvDLRHIYTQV-IDSATQPLVPHYDYDSNVLFLSGKGDRFVNMFEVIYDSpyLLPLAPFMSPVGSQGIAFHQ 915
Cdd:PTZ00421  238 QIMLWDTR--KMASPYSTVdLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMP 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  916 KLKCNVMAVEFQVCWRLSDKNLEKITFRVPRIKKDV-FQDDLFPDSLVTwEPVTTGTKWMLGEQAAPVFRSLKpdGVFSS 994
Cdd:PTZ00421  314 KWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQADSeLQVDVYPPTFAD-HPAITADEYFSGGNAEPLVYDMS--AVFDG 390

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 453232062  995 I-PRAITASV-------RHSEMPSSSSTTNSAAQTPSTSVTHS 1029
Cdd:PTZ00421  391 TsPELMGASAlspsgkpRHSGVSVPASTSAMTHSFDDNTSKHA 433
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 99-427 8.61e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 121.92  E-value: 8.61e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062   99 GKLGVLPITAKGRRTRNDIGIIAAHGeQVADFGFLTFADELLATCSRDEPVKIWKLSRD--HSPKLATEIDVGGGNVIAE 176
Cdd:PTZ00421   51 GSTAVLKHTDYGKLASNPPILLGQEG-PIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEglTQNISDPIVHLQGHTKKVG 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  177 CLRAHSTADNILA-VGSHGSTYITDISTGKTAVELSGVTDKVQSMDWSEDGKLLAV-SGDKGRQIVvyDPRASmEPIQTL 254
Cdd:PTZ00421  130 IVSFHPSAMNVLAsAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTtSKDKKLNII--DPRDG-TIVSSV 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  255 EGHGGmGREARVLFA--GNRLISTGFTTKRIQEVRAYDTGKWGAPVHTQEFVSTTGVLIPHYDADTRLVFLSGKGTNKLF 332
Cdd:PTZ00421  207 EAHAS-AKSQRCLWAkrKDLIITLGCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIR 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  333 MLEMQDRQpyLSHVFELTLPEQTLGATIGAKRRVHVMDGEVDTYYQLTKSSIVPTPCIVPRR-SYRDFHSDLFPETRGAE 411
Cdd:PTZ00421  286 CFELMNER--LTFCSSYSSVEPHKGLCMMPKWSLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSELQVDVYPPTFADH 363

                         330
                  ....*....|....*.
gi 453232062  412 PGCTAGEWLNGTNAVP 427
Cdd:PTZ00421  364 PAITADEYFSGGNAEP 379
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 3-111 1.75e-11

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


:

Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 60.59  E-value: 1.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062     3 WRFAASKFKNTTPKVPKKENEYDDgdeasveedhyddltsesnngvgsrrrsravsckikfntetifdVPVGNLSCTNDG 82
Cdd:pfam08953    1 RFVRASKFRHVYGKPAKKELCYDN--------------------------------------------IKVTKNAWDSNF 36

                           90       100       110
                   ....*....|....*....|....*....|
gi 453232062    83 IHASADFLAFHIEGEG-GKLGVLPITAKGR 111
Cdd:pfam08953   37 IAANPKFLAVNWESSGgGAFAVLPLNQTGR 66
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 599-1029 1.44e-36

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 145.42  E-value: 1.44e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  599 SKFRHVDGQQGtKSGAVFSNLrNVNTRLPPESNGVCCSNKFAAVPLAGLGVIGIYDVNEPGKLPDGVMDGIFNKTLVTDL 678
Cdd:PTZ00421    4 SRFRHTQGVPA-RPDRHFLNV-TPSTALWDCSNTIACNDRFIAVPWQQLGSTAVLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  679 HWNPFDDEQLAVGTDCGQINLWRLTTNDGPRNEMEPekIIKIGG--EKITSLRWHPLASDLLAVALSNSTIELWDVANAK 756
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDP--IVHLQGhtKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  757 LYSRFVNHTGGILGIAWSADGRRIASVGKDATLFVHEPasREQRVYERKTVVESTRAARVLFACDDRIVIVVGMTKSSQR 836
Cdd:PTZ00421  160 AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDP--RDGTIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQR 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  837 QVQMYDAQtvDLRHIYTQV-IDSATQPLVPHYDYDSNVLFLSGKGDRFVNMFEVIYDSpyLLPLAPFMSPVGSQGIAFHQ 915
Cdd:PTZ00421  238 QIMLWDTR--KMASPYSTVdLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMP 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  916 KLKCNVMAVEFQVCWRLSDKNLEKITFRVPRIKKDV-FQDDLFPDSLVTwEPVTTGTKWMLGEQAAPVFRSLKpdGVFSS 994
Cdd:PTZ00421  314 KWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQADSeLQVDVYPPTFAD-HPAITADEYFSGGNAEPLVYDMS--AVFDG 390

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 453232062  995 I-PRAITASV-------RHSEMPSSSSTTNSAAQTPSTSVTHS 1029
Cdd:PTZ00421  391 TsPELMGASAlspsgkpRHSGVSVPASTSAMTHSFDDNTSKHA 433
PTZ00421 PTZ00421
coronin; Provisional
 99-427 8.61e-29

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 121.92  E-value: 8.61e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062   99 GKLGVLPITAKGRRTRNDIGIIAAHGeQVADFGFLTFADELLATCSRDEPVKIWKLSRD--HSPKLATEIDVGGGNVIAE 176
Cdd:PTZ00421   51 GSTAVLKHTDYGKLASNPPILLGQEG-PIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEglTQNISDPIVHLQGHTKKVG 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  177 CLRAHSTADNILA-VGSHGSTYITDISTGKTAVELSGVTDKVQSMDWSEDGKLLAV-SGDKGRQIVvyDPRASmEPIQTL 254
Cdd:PTZ00421  130 IVSFHPSAMNVLAsAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTtSKDKKLNII--DPRDG-TIVSSV 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  255 EGHGGmGREARVLFA--GNRLISTGFTTKRIQEVRAYDTGKWGAPVHTQEFVSTTGVLIPHYDADTRLVFLSGKGTNKLF 332
Cdd:PTZ00421  207 EAHAS-AKSQRCLWAkrKDLIITLGCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIR 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  333 MLEMQDRQpyLSHVFELTLPEQTLGATIGAKRRVHVMDGEVDTYYQLTKSSIVPTPCIVPRR-SYRDFHSDLFPETRGAE 411
Cdd:PTZ00421  286 CFELMNER--LTFCSSYSSVEPHKGLCMMPKWSLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSELQVDVYPPTFADH 363

                         330
                  ....*....|....*.
gi 453232062  412 PGCTAGEWLNGTNAVP 427
Cdd:PTZ00421  364 PAITADEYFSGGNAEP 379
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 384-427 2.61e-16

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 73.32  E-value: 2.61e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 453232062   384 IVPTPCIVPRRSYRDFHSDLFPETRGAEPGCTAGEWLNGTNAVP 427
Cdd:pfam16300    1 IEPISFTVPRKSKEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 COG2319
WD40 repeat [General function prediction only];
675-853 3.57e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.88  E-value: 3.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  675 VTDLHWNPfDDEQLAVGTDCGQINLWRLTTNdgprnemEPEKIIKIGGEKITSLRWHPlASDLLAVALSNSTIELWDVAN 754
Cdd:COG2319   207 VRSVAFSP-DGKLLASGSADGTVRLWDLATG-------KLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLAT 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  755 AKLYSRFVNHTGGILGIAWSADGRRIASVGKDATLFVHEPASREqrvyERKTVVESTRAAR-VLFACDDRIVIVVgmtkS 833
Cdd:COG2319   278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK----LLRTLTGHTGAVRsVAFSPDGKTLASG----S 349

                         170       180
                  ....*....|....*....|
gi 453232062  834 SQRQVQMYDAQTVDLRHIYT 853
Cdd:COG2319   350 DDGTVRLWDLATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
112-278 9.90e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 9.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  112 RTRNDIGIIAAHGEQVADfgfLTFA--DELLATCSRDEPVKIWKLSrdhSPKLATEIDVGGGNVIAecLrAHSTADNILA 189
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRS---VAFSpdGRLLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNS--V-AFSPDGKLLA 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  190 VGSHGST-YITDISTGKTAVELSGVTDKVQSMDWSEDGKLLAVSGDKGRqIVVYDPrASMEPIQTLEGHGGMGREARVLF 268
Cdd:COG2319   305 SGSDDGTvRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT-VRLWDL-ATGELLRTLTGHTGAVTSVAFSP 382

                         170
                  ....*....|
gi 453232062  269 AGNRLISTGF 278
Cdd:COG2319   383 DGRTLASGSA 392
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 3-111 1.75e-11

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 60.59  E-value: 1.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062     3 WRFAASKFKNTTPKVPKKENEYDDgdeasveedhyddltsesnngvgsrrrsravsckikfntetifdVPVGNLSCTNDG 82
Cdd:pfam08953    1 RFVRASKFRHVYGKPAKKELCYDN--------------------------------------------IKVTKNAWDSNF 36

                           90       100       110
                   ....*....|....*....|....*....|
gi 453232062    83 IHASADFLAFHIEGEG-GKLGVLPITAKGR 111
Cdd:pfam08953   37 IAANPKFLAVNWESSGgGAFAVLPLNQTGR 66
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 937-981 2.70e-11

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 59.45  E-value: 2.70e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 453232062   937 LEKITFRVPRIKKDVFQDDLFPDSLVTWEPVtTGTKWMLGEQAAP 981
Cdd:pfam16300    1 IEPISFTVPRKSKEDFQDDLYPDTAGTEPAL-TAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 716-791 6.04e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 6.04e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 453232062  716 KIIKIGGEKITSLRWHPlASDLLAVALSNSTIELWDVANAKLYSRFVNHTGGILGIAWSADGRRIASVGKDATLFV 791
Cdd:cd00200     3 RTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 138-277 1.07e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  138 ELLATCSRDEPVKIWKLSRDHSPKLateiDVGGGNVIAECLrAHSTADNILAVGSHGSTYITDISTGKTAVELSGVTDKV 217
Cdd:cd00200    22 KLLATGSGDGTIKVWDLETGELLRT----LKGHTGPVRDVA-ASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYV 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 453232062  218 QSMDWSEDGKLLAVSG-DKgrQIVVYDPRASmEPIQTLEGHGGMGREARVLFaGNRLISTG 277
Cdd:cd00200    97 SSVAFSPDGRILSSSSrDK--TIKVWDVETG-KCLTTLRGHTDWVNSVAFSP-DGTFVASS 153
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 756-793 3.56e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 3.56e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 453232062    756 KLYSRFVNHTGGILGIAWSADGRRIASVGKDATLFVHE 793
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 599-1029 1.44e-36

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 145.42  E-value: 1.44e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  599 SKFRHVDGQQGtKSGAVFSNLrNVNTRLPPESNGVCCSNKFAAVPLAGLGVIGIYDVNEPGKLPDGVMDGIFNKTLVTDL 678
Cdd:PTZ00421    4 SRFRHTQGVPA-RPDRHFLNV-TPSTALWDCSNTIACNDRFIAVPWQQLGSTAVLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  679 HWNPFDDEQLAVGTDCGQINLWRLTTNDGPRNEMEPekIIKIGG--EKITSLRWHPLASDLLAVALSNSTIELWDVANAK 756
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDP--IVHLQGhtKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  757 LYSRFVNHTGGILGIAWSADGRRIASVGKDATLFVHEPasREQRVYERKTVVESTRAARVLFACDDRIVIVVGMTKSSQR 836
Cdd:PTZ00421  160 AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDP--RDGTIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQR 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  837 QVQMYDAQtvDLRHIYTQV-IDSATQPLVPHYDYDSNVLFLSGKGDRFVNMFEVIYDSpyLLPLAPFMSPVGSQGIAFHQ 915
Cdd:PTZ00421  238 QIMLWDTR--KMASPYSTVdLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMP 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  916 KLKCNVMAVEFQVCWRLSDKNLEKITFRVPRIKKDV-FQDDLFPDSLVTwEPVTTGTKWMLGEQAAPVFRSLKpdGVFSS 994
Cdd:PTZ00421  314 KWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQADSeLQVDVYPPTFAD-HPAITADEYFSGGNAEPLVYDMS--AVFDG 390

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 453232062  995 I-PRAITASV-------RHSEMPSSSSTTNSAAQTPSTSVTHS 1029
Cdd:PTZ00421  391 TsPELMGASAlspsgkpRHSGVSVPASTSAMTHSFDDNTSKHA 433
PTZ00421 PTZ00421
coronin; Provisional
 99-427 8.61e-29

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 121.92  E-value: 8.61e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062   99 GKLGVLPITAKGRRTRNDIGIIAAHGeQVADFGFLTFADELLATCSRDEPVKIWKLSRD--HSPKLATEIDVGGGNVIAE 176
Cdd:PTZ00421   51 GSTAVLKHTDYGKLASNPPILLGQEG-PIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEglTQNISDPIVHLQGHTKKVG 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  177 CLRAHSTADNILA-VGSHGSTYITDISTGKTAVELSGVTDKVQSMDWSEDGKLLAV-SGDKGRQIVvyDPRASmEPIQTL 254
Cdd:PTZ00421  130 IVSFHPSAMNVLAsAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTtSKDKKLNII--DPRDG-TIVSSV 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  255 EGHGGmGREARVLFA--GNRLISTGFTTKRIQEVRAYDTGKWGAPVHTQEFVSTTGVLIPHYDADTRLVFLSGKGTNKLF 332
Cdd:PTZ00421  207 EAHAS-AKSQRCLWAkrKDLIITLGCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIR 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  333 MLEMQDRQpyLSHVFELTLPEQTLGATIGAKRRVHVMDGEVDTYYQLTKSSIVPTPCIVPRR-SYRDFHSDLFPETRGAE 411
Cdd:PTZ00421  286 CFELMNER--LTFCSSYSSVEPHKGLCMMPKWSLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSELQVDVYPPTFADH 363

                         330
                  ....*....|....*.
gi 453232062  412 PGCTAGEWLNGTNAVP 427
Cdd:PTZ00421  364 PAITADEYFSGGNAEP 379
PTZ00420 PTZ00420
coronin; Provisional
 612-976 1.86e-25

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 112.35  E-value: 1.86e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  612 SGAVFSNLRnVNTRLPpESNGVCCSNKFAAVP--LAGLGVIGIYDV-NEPGKLPDGVMDGifNKTLVTDLHWNPFDDEQL 688
Cdd:PTZ00420   15 SNNLFDDLR-ICSRVI-DSCGIACSSGFVAVPweVEGGGLIGAIRLeNQMRKPPVIKLKG--HTSSILDLQFNPCFSEIL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  689 AVGTDCGQINLWRLTTNDGPRNEM-EPEKIIKIGGEKITSLRWHPLASDLLAVALSNSTIELWDVANAKLYSRfVNHTGG 767
Cdd:PTZ00420   91 ASGSEDLTIRVWEIPHNDESVKEIkDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQ-INMPKK 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  768 ILGIAWSADGRRIASVGKDATLFVHEPasREQRVYERKTVVESTRAARVL----FACDDRIVIVVGMTKSSQRQVQMYDA 843
Cdd:PTZ00420  170 LSSLKWNIKGNLLSGTCVGKHMHIIDP--RKQEIASSFHIHDGGKNTKNIwidgLGGDDNYILSTGFSKNNMREMKLWDL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  844 QTVDlRHIYTQVIDSATQPLVPHYDYDSNVLFLSGKGDRFVNMFEVIYDSPYLLPLAPFMSPVGSQGiaFHQKLKCNVMA 923
Cdd:PTZ00420  248 KNTT-SALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGSIRKVNEYKSCSPFRSFG--FLPKQICDVYK 324

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 453232062  924 VEF-QVCWRLSDKNLEKITFRVPRIKKDVFQDDLFPDSLVTwEPVTTGTKWMLG 976
Cdd:PTZ00420  325 CEIgRVYKNENNSSIRPISFYVPRKNPTKFQEDLYPPILMH-DPERSSRNWIDG 377
PTZ00420 PTZ00420
coronin; Provisional
 77-424 2.83e-20

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 96.17  E-value: 2.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062   77 SCtndGIHASADFLAFHIEGEGGKL-GVLPITAKGRRTrnDIGIIAAHGEQVADFGFLTFADELLATCSRDEPVKIWKLS 155
Cdd:PTZ00420   31 SC---GIACSSGFVAVPWEVEGGGLiGAIRLENQMRKP--PVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIP 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  156 rdHSPKLATEIDvgggnvIAEC-LRAHSTADNIL-----------AVGSHGSTYITDISTGKTAVELSgVTDKVQSMDWS 223
Cdd:PTZ00420  106 --HNDESVKEIK------DPQCiLKGHKKKISIIdwnpmnyyimcSSGFDSFVNIWDIENEKRAFQIN-MPKKLSSLKWN 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  224 EDGKLLavSGD-KGRQIVVYDPRASmEPIQTLEGHGGmGREARVL----FAG--NRLISTGFTTKRIQEVRAYDTGKWGA 296
Cdd:PTZ00420  177 IKGNLL--SGTcVGKHMHIIDPRKQ-EIASSFHIHDG-GKNTKNIwidgLGGddNYILSTGFSKNNMREMKLWDLKNTTS 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  297 PVHTQEFVSTTGVLIPHYDADTRLVFLSGKGTNKLFMleMQDRQPYLSHVFELT--LPEQTLGATigAKRRVHVMDGEVD 374
Cdd:PTZ00420  253 ALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRY--YQHSLGSIRKVNEYKscSPFRSFGFL--PKQICDVYKCEIG 328

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 453232062  375 TYYQ-LTKSSIVPTPCIVPRRSYRDFHSDLFPETRGAEPGCTAGEWLNGTN 424
Cdd:PTZ00420  329 RVYKnENNSSIRPISFYVPRKNPTKFQEDLYPPILMHDPERSSRNWIDGKD 379
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 384-427 2.61e-16

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 73.32  E-value: 2.61e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 453232062   384 IVPTPCIVPRRSYRDFHSDLFPETRGAEPGCTAGEWLNGTNAVP 427
Cdd:pfam16300    1 IEPISFTVPRKSKEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 COG2319
WD40 repeat [General function prediction only];
675-853 3.57e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.88  E-value: 3.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  675 VTDLHWNPfDDEQLAVGTDCGQINLWRLTTNdgprnemEPEKIIKIGGEKITSLRWHPlASDLLAVALSNSTIELWDVAN 754
Cdd:COG2319   207 VRSVAFSP-DGKLLASGSADGTVRLWDLATG-------KLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLAT 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  755 AKLYSRFVNHTGGILGIAWSADGRRIASVGKDATLFVHEPASREqrvyERKTVVESTRAAR-VLFACDDRIVIVVgmtkS 833
Cdd:COG2319   278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK----LLRTLTGHTGAVRsVAFSPDGKTLASG----S 349

                         170       180
                  ....*....|....*....|
gi 453232062  834 SQRQVQMYDAQTVDLRHIYT 853
Cdd:COG2319   350 DDGTVRLWDLATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
675-853 4.61e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.80  E-value: 4.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  675 VTDLHWNPfDDEQLAVGTDCGQINLWRLTTNdgprnemEPEKIIKIGGEKITSLRWHPlASDLLAVALSNSTIELWDVAN 754
Cdd:COG2319   123 VRSVAFSP-DGKTLASGSADGTVRLWDLATG-------KLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLAT 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  755 AKLYSRFVNHTGGILGIAWSADGRRIASVGKDATLFVHEPASREqrvyERKTVVESTRAAR-VLFACDDRIVIVVgmtkS 833
Cdd:COG2319   194 GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK----LLRTLTGHSGSVRsVAFSPDGRLLASG----S 265

                         170       180
                  ....*....|....*....|
gi 453232062  834 SQRQVQMYDAQTVDLRHIYT 853
Cdd:COG2319   266 ADGTVRLWDLATGELLRTLT 285
WD40 COG2319
WD40 repeat [General function prediction only];
648-789 1.20e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.26  E-value: 1.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  648 GVIGIYDVN--EPGKLPDGVMDGifnktlVTDLHWNPfDDEQLAVGTDCGQINLWRLTTNdgprnemEPEKIIKIGGEKI 725
Cdd:COG2319   268 GTVRLWDLAtgELLRTLTGHSGG------VNSVAFSP-DGKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAV 333

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 453232062  726 TSLRWHPlASDLLAVALSNSTIELWDVANAKLYSRFVNHTGGILGIAWSADGRRIASVGKDATL 789
Cdd:COG2319   334 RSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
112-278 9.90e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 9.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  112 RTRNDIGIIAAHGEQVADfgfLTFA--DELLATCSRDEPVKIWKLSrdhSPKLATEIDVGGGNVIAecLrAHSTADNILA 189
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRS---VAFSpdGRLLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNS--V-AFSPDGKLLA 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  190 VGSHGST-YITDISTGKTAVELSGVTDKVQSMDWSEDGKLLAVSGDKGRqIVVYDPrASMEPIQTLEGHGGMGREARVLF 268
Cdd:COG2319   305 SGSDDGTvRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT-VRLWDL-ATGELLRTLTGHTGAVTSVAFSP 382

                         170
                  ....*....|
gi 453232062  269 AGNRLISTGF 278
Cdd:COG2319   383 DGRTLASGSA 392
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 3-111 1.75e-11

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 60.59  E-value: 1.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062     3 WRFAASKFKNTTPKVPKKENEYDDgdeasveedhyddltsesnngvgsrrrsravsckikfntetifdVPVGNLSCTNDG 82
Cdd:pfam08953    1 RFVRASKFRHVYGKPAKKELCYDN--------------------------------------------IKVTKNAWDSNF 36

                           90       100       110
                   ....*....|....*....|....*....|
gi 453232062    83 IHASADFLAFHIEGEG-GKLGVLPITAKGR 111
Cdd:pfam08953   37 IAANPKFLAVNWESSGgGAFAVLPLNQTGR 66
WD40 COG2319
WD40 repeat [General function prediction only];
112-322 2.57e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.86  E-value: 2.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  112 RTRNDIGIIAAHGEQVADFGFltFAD-ELLATCSRDEPVKIWklsrdhspklateiDVGGGNVIAEcLRAHSTA------ 184
Cdd:COG2319   150 ATGKLLRTLTGHSGAVTSVAF--SPDgKLLASGSDDGTVRLW--------------DLATGKLLRT-LTGHTGAvrsvaf 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  185 ---DNILAVGSHGST-YITDISTGKTAVELSGVTDKVQSMDWSEDGKLLAvSGDKGRQIVVYDPRASmEPIQTLEGHGGM 260
Cdd:COG2319   213 spdGKLLASGSADGTvRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLA-SGSADGTVRLWDLATG-ELLRTLTGHSGG 290

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 453232062  261 GREARVLFAGNRLISTGfttkRIQEVRAYDTGKwGAPVHTqefvsttgvLIPHYDADTRLVF 322
Cdd:COG2319   291 VNSVAFSPDGKLLASGS----DDGTVRLWDLAT-GKLLRT---------LTGHTGAVRSVAF 338
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 937-981 2.70e-11

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 59.45  E-value: 2.70e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 453232062   937 LEKITFRVPRIKKDVFQDDLFPDSLVTWEPVtTGTKWMLGEQAAP 981
Cdd:pfam16300    1 IEPISFTVPRKSKEDFQDDLYPDTAGTEPAL-TAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 716-791 6.04e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 6.04e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 453232062  716 KIIKIGGEKITSLRWHPlASDLLAVALSNSTIELWDVANAKLYSRFVNHTGGILGIAWSADGRRIASVGKDATLFV 791
Cdd:cd00200     3 RTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77
WD40 COG2319
WD40 repeat [General function prediction only];
65-300 8.25e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 8.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062   65 TETIFDVPVGNLSCTNDGIHASADFLAFHIEGEGGKLGVLPITAKGRRTRNDIGIIAAHGEQVADFGFLTFAD-ELLATC 143
Cdd:COG2319    17 ALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDgRLLASA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  144 SRDEPVKIWKLSrdhSPKLATEIDVGGGNVIAeclRAHSTADNILAVGSHGST-YITDISTGKTAVELSGVTDKVQSMDW 222
Cdd:COG2319    97 SADGTVRLWDLA---TGLLLRTLTGHTGAVRS---VAFSPDGKTLASGSADGTvRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 453232062  223 SEDGKLLAvSGDKGRQIVVYDPRASmEPIQTLEGHGGMGREARVLFAGNRLISTGFTtkriQEVRAYDTGKwGAPVHT 300
Cdd:COG2319   171 SPDGKLLA-SGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKLLASGSAD----GTVRLWDLAT-GKLLRT 241
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 675-789 1.10e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 1.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  675 VTDLHWNPfDDEQLAVGTDCGQINLWRLTTndgprnemepEKIIKIG---GEKITSLRWHPlASDLLAVALSNSTIELWD 751
Cdd:cd00200   180 VNSVAFSP-DGEKLLSSSSDGTIKLWDLST----------GKCLGTLrghENGVNSVAFSP-DGYLLASGSEDGTIRVWD 247

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 453232062  752 VANAKLYSRFVNHTGGILGIAWSADGRRIASVGKDATL 789
Cdd:cd00200   248 LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 675-799 1.95e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 1.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  675 VTDLHWNPfdDEQLAVGT--DcGQINLWRLTTNdgprnemepEKIIKIGGEK--ITSLRWHPlASDLLAVALSNSTIELW 750
Cdd:cd00200    96 VSSVAFSP--DGRILSSSsrD-KTIKVWDVETG---------KCLTTLRGHTdwVNSVAFSP-DGTFVASSSQDGTIKLW 162

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 453232062  751 DVANAKLYSRFVNHTGGILGIAWSADGRRIASVGKDATLFVHEPASREQ 799
Cdd:cd00200   163 DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 675-889 3.22e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 3.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  675 VTDLHWNPfDDEQLAVGTDCGQINLWRLTTNdgprnemEPEKIIKIGGEKITSLRWHPlASDLLAVALSNSTIELWDVAN 754
Cdd:cd00200    12 VTCVAFSP-DGKLLATGSGDGTIKVWDLETG-------ELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  755 AKLYSRFVNHTGGILGIAWSADGRRIASVGKDATLFVHEPASREQrvyeRKTVVESTRAARVLFACDDRIVIVVGmtkSS 834
Cdd:cd00200    83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC----LTTLRGHTDWVNSVAFSPDGTFVASS---SQ 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 453232062  835 QRQVQMYDAQTvdLRHIYTqvidsatqpLVPHYDY-------DSNVLFLSGKGDRFVNMFEV 889
Cdd:cd00200   156 DGTIKLWDLRT--GKCVAT---------LTGHTGEvnsvafsPDGEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
736-853 5.10e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 5.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  736 DLLAVALSNSTIELWDVANAKLYSRFVNHTGGILGIAWSADGRRIASVGKDATLFVHEPASREqrvyERKTVVESTRAAR 815
Cdd:COG2319    91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK----LLRTLTGHSGAVT 166

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 453232062  816 -VLFACDDRIVIVVgmtkSSQRQVQMYDAQTVDLRHIYT 853
Cdd:COG2319   167 sVAFSPDGKLLASG----SDDGTVRLWDLATGKLLRTLT 201
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 138-277 1.07e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  138 ELLATCSRDEPVKIWKLSRDHSPKLateiDVGGGNVIAECLrAHSTADNILAVGSHGSTYITDISTGKTAVELSGVTDKV 217
Cdd:cd00200    22 KLLATGSGDGTIKVWDLETGELLRT----LKGHTGPVRDVA-ASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYV 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 453232062  218 QSMDWSEDGKLLAVSG-DKgrQIVVYDPRASmEPIQTLEGHGGMGREARVLFaGNRLISTG 277
Cdd:cd00200    97 SSVAFSPDGRILSSSSrDK--TIKVWDVETG-KCLTTLRGHTDWVNSVAFSP-DGTFVASS 153
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 112-278 1.18e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  112 RTRNDIGIIAAHGEQVADFGFLTFaDELLATCSRDEPVKIWKLSrdhSPKLATEIDVGGGNViaECLRAHSTADNILAVG 191
Cdd:cd00200   123 ETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLR---TGKCVATLTGHTGEV--NSVAFSPDGEKLLSSS 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  192 SHGSTYITDISTGKTAVELSGVTDKVQSMDWSEDGKLLaVSGDKGRQIVVYDPRaSMEPIQTLEGHggmgrEARVL---F 268
Cdd:cd00200   197 SDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLL-ASGSEDGTIRVWDLR-TGECVQTLSGH-----TNSVTslaW 269

                         170
                  ....*....|..
gi 453232062  269 A--GNRLISTGF 278
Cdd:cd00200   270 SpdGKRLASGSA 281
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 680-774 1.60e-08

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 53.05  E-value: 1.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062   680 WNPFDDeQLAVGTDCGQINLWRLttnDGprnemepEKIIKI----GGEKITSLRWHPLASdLLAVALSNSTIELWDVANA 755
Cdd:pfam12894    3 WCPTMD-LIALATEDGELLLHRL---NW-------QRVWTLspdkEDLEVTSLAWRPDGK-LLAVGYSDGTVRLLDAENG 70

                           90
                   ....*....|....*....
gi 453232062   756 KLYSRFVNHTGGILGIAWS 774
Cdd:pfam12894   71 KIVHHFSAGSDLITCLGWG 89
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 123-257 1.39e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 1.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  123 HGEQVADFGFLTFaDELLATCSRDEPVKIWKLSrdhSPKLATEIDVGGGNVIaeCLRAHSTADNILAVGSHGSTYITDIS 202
Cdd:cd00200    50 HTGPVRDVAASAD-GTYLASGSSDKTIRLWDLE---TGECVRTLTGHTSYVS--SVAFSPDGRILSSSSRDKTIKVWDVE 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 453232062  203 TGKTAVELSGVTDKVQSMDWSEDGKLLAVSGDKGrQIVVYDPRaSMEPIQTLEGH 257
Cdd:cd00200   124 TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG-TIKLWDLR-TGKCVATLTGH 176
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 598-660 6.45e-07

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 47.49  E-value: 6.45e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 453232062   598 TSKFRHVDGQQGTKSGAvFSNLRnvNTRLPPESNGVCCSNKFAAVPL--AGLGVIGIYDVNEPGK 660
Cdd:pfam08953    5 ASKFRHVYGKPAKKELC-YDNIK--VTKNAWDSNFIAANPKFLAVNWesSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 138-235 3.06e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 3.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  138 ELLATCSRDEPVKIWKLSRDHSPKLATeidvgGGNVIAECLrAHSTADNILAVGSH-GSTYITDISTGKTAVELSGVTDK 216
Cdd:cd00200   190 EKLLSSSSDGTIKLWDLSTGKCLGTLR-----GHENGVNSV-AFSPDGYLLASGSEdGTIRVWDLRTGECVQTLSGHTNS 263

                          90       100
                  ....*....|....*....|
gi 453232062  217 VQSMDWSEDGKLLAV-SGDK 235
Cdd:cd00200   264 VTSLAWSPDGKRLASgSADG 283
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 756-793 3.56e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 3.56e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 453232062    756 KLYSRFVNHTGGILGIAWSADGRRIASVGKDATLFVHE 793
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
111-330 3.23e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.45  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  111 RRTRNDIGIIAAHGEQVADFGFLTFADELLATCSRDEPVKIWKLSRDHSPKLATEIDVGGGNVIAECLRAHSTAD-NILA 189
Cdd:COG3391     4 ASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADgRRLY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232062  190 VGSHGSTYIT--DISTGKTAVELSgVTDKVQSMDWSEDGKLLAVSGDKGRQIVVYDPrASMEPIQTLEGhGGMGREARVL 267
Cdd:COG3391    84 VANSGSGRVSviDLATGKVVATIP-VGGGPRGLAVDPDGGRLYVADSGNGRVSVIDT-ATGKVVATIPV-GAGPHGIAVD 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 453232062  268 FAGNRLISTGFTTKRIQE-VRAYDTGKWgapvhtqEFVSTTGVL-IPH---YDADTRLVFLSGKGTNK 330
Cdd:COG3391   161 PDGKRLYVANSGSNTVSViVSVIDTATG-------KVVATIPVGgGPVgvaVSPDGRRLYVANRGSNT 221
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 209-278 4.71e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 4.71e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 453232062  209 ELSGVTDKVQSMDWSEDGKLLAV-SGDKgrQIVVYDpRASMEPIQTLEGHGGMGREARVLFAGNRLISTGF 278
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATgSGDG--TIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSS 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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