NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|453232288|ref|NP_001263810|]
View 

F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 119-258 5.41e-43

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 143.87  E-value: 5.41e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232288  119 FENVLEMLQSLNfKLCVKNFSVARFPLKYVISFFKCLAAEQIENITFySDEYDEENPKELVKLEQWKKAKFIEIYGGYTF 198
Cdd:pfam01827   4 IESFLNILKSKK-CLHVKEISLSGLSFSEVASILPYFDAGTLEEIEL-SSESDEDQFEEIVELEQWKNAKSLKIEGSSLS 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232288  199 PFKVEDFLHFTTFWVRLGHFTTEDAAKVRDVLMKPNNINYGYFDFSIYDPIAIARIFEPN 258
Cdd:pfam01827  82 SFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
F-box_SF super family cl45894
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 13-43 5.21e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


The actual alignment was detected with superfamily member cd22150:

Pssm-ID: 459239  Cd Length: 46  Bit Score: 37.08  E-value: 5.21e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 453232288  13 LAAIDRIAVQKVSRGFRDVINREDFGVKRLS 43
Cdd:cd22150   16 LDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 119-258 5.41e-43

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 143.87  E-value: 5.41e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232288  119 FENVLEMLQSLNfKLCVKNFSVARFPLKYVISFFKCLAAEQIENITFySDEYDEENPKELVKLEQWKKAKFIEIYGGYTF 198
Cdd:pfam01827   4 IESFLNILKSKK-CLHVKEISLSGLSFSEVASILPYFDAGTLEEIEL-SSESDEDQFEEIVELEQWKNAKSLKIEGSSLS 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232288  199 PFKVEDFLHFTTFWVRLGHFTTEDAAKVRDVLMKPNNINYGYFDFSIYDPIAIARIFEPN 258
Cdd:pfam01827  82 SFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 13-43 5.21e-04

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 37.08  E-value: 5.21e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 453232288  13 LAAIDRIAVQKVSRGFRDVINREDFGVKRLS 43
Cdd:cd22150   16 LDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 119-258 5.41e-43

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 143.87  E-value: 5.41e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232288  119 FENVLEMLQSLNfKLCVKNFSVARFPLKYVISFFKCLAAEQIENITFySDEYDEENPKELVKLEQWKKAKFIEIYGGYTF 198
Cdd:pfam01827   4 IESFLNILKSKK-CLHVKEISLSGLSFSEVASILPYFDAGTLEEIEL-SSESDEDQFEEIVELEQWKNAKSLKIEGSSLS 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232288  199 PFKVEDFLHFTTFWVRLGHFTTEDAAKVRDVLMKPNNINYGYFDFSIYDPIAIARIFEPN 258
Cdd:pfam01827  82 SFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 13-43 5.21e-04

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 37.08  E-value: 5.21e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 453232288  13 LAAIDRIAVQKVSRGFRDVINREDFGVKRLS 43
Cdd:cd22150   16 LDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH