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Conserved domains on  [gi|453232510|ref|NP_001263869|]
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Potassium channel domain-containing protein [Caenorhabditis elegans]

Protein Classification

potassium channel family protein( domain architecture ID 10545436)

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium, translocate across cell membranes

Gene Ontology:  GO:0005267|GO:0034220|GO:0005216|GO:0071805|GO:0016020
PubMed:  15816170|9525859|11836519|11178249|1772658
SCOP:  4000034
TCDB:  1.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 179-234 2.08e-17

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 76.92  E-value: 2.08e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 453232510  179 KWSFMSSIFFSWTAITTIGYGHIVPRTDEGRVAIIFYALLGIPLILVTIADIGRFL 234
Cdd:pfam07885  21 EWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 366-443 1.35e-14

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 68.83  E-value: 1.35e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 453232510  366 ILLIMLGYVAGGAYIVRWWEEWTFFEAFYFCFVTVTTIGFGDIVPANVDWLPATLAYIVFGLIITTMCIDLVGSEYIR 443
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLEEGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 179-234 2.08e-17

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 76.92  E-value: 2.08e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 453232510  179 KWSFMSSIFFSWTAITTIGYGHIVPRTDEGRVAIIFYALLGIPLILVTIADIGRFL 234
Cdd:pfam07885  21 EWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 366-443 1.35e-14

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 68.83  E-value: 1.35e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 453232510  366 ILLIMLGYVAGGAYIVRWWEEWTFFEAFYFCFVTVTTIGFGDIVPANVDWLPATLAYIVFGLIITTMCIDLVGSEYIR 443
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLEEGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
PRK10537 PRK10537
voltage-gated potassium channel protein;
392-427 1.51e-03

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 41.16  E-value: 1.51e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 453232510 392 AFYFCFVTVTTIGFGDIVPANVDWLPATLAYIVFGL 427
Cdd:PRK10537 172 AFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGI 207
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 179-234 2.08e-17

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 76.92  E-value: 2.08e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 453232510  179 KWSFMSSIFFSWTAITTIGYGHIVPRTDEGRVAIIFYALLGIPLILVTIADIGRFL 234
Cdd:pfam07885  21 EWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 366-443 1.35e-14

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 68.83  E-value: 1.35e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 453232510  366 ILLIMLGYVAGGAYIVRWWEEWTFFEAFYFCFVTVTTIGFGDIVPANVDWLPATLAYIVFGLIITTMCIDLVGSEYIR 443
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLEEGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 363-429 5.86e-04

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 41.87  E-value: 5.86e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 453232510  363 VLFILLIMLGYVAGG----AYIVRWWEEW--------TFFEAFYFCFVTVTTIGFGDIVPANVDWLPATLAYIVFGLII 429
Cdd:pfam00520 133 LLLLLLFLFIFAIIGyqlfGGKLKTWENPdngrtnfdNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIYFVSFI 211
PRK10537 PRK10537
voltage-gated potassium channel protein;
392-427 1.51e-03

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 41.16  E-value: 1.51e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 453232510 392 AFYFCFVTVTTIGFGDIVPANVDWLPATLAYIVFGL 427
Cdd:PRK10537 172 AFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGI 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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