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Conserved domains on  [gi|453232592|ref|NP_001263893|]
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Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

Protein Classification

MoaD/ThiS family protein; Ubl5/Hub1 family ubiquitin-like protein( domain architecture ID 10371398)

MoaD/ThiS family protein is a ubiquitin-like protein, may be involved in sulfur transfer| Ubl5/Hub1 family ubiquitin-like protein similar to Saccharomyces cerevisiae Hub1 that plays a role in splice-site usage and alternative splicing

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RA_Rin cd01776
Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family; Family of ...
 921-1009 3.44e-33

Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family; Family of Ras-interaction/interference (Rin) proteins, also known as Ras and Rab interactors, is composed of Rin1, Rin2, and Rin3, which have multifunctional domains, including SH2 and proline-rich domains in the N-terminal region, and RH, VPS9, and RA domains in the C-terminal region. RA domain-containing proteins function by interacting with Ras proteins directly or indirectly and are involved in several different functions ranging from tumor suppression to being oncoproteins. Ras proteins are small GTPases that are involved in cellular signal transduction. The RA domain has the beta-grasp ubiquitin-like (Ubl) fold with low sequence similarity to ubiquitin; ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. The RA domains of Rin1, Rin2, and Rin3 are well conserved and they all have Ras binding characteristics.


:

Pssm-ID: 340474  Cd Length: 90  Bit Score: 123.17  E-value: 3.44e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232592  921 DAFVKIAVPDEAVGCVRYATFPGVPMLTTSKLSRLVAHQQGITNPEEHGLYLIAEGFESCLSPSECPVLVHEQLK-KDKK 999
Cdd:cd01776     1 QGFLRVAVPDENNGSIVSKTLPVRPSMTAREVCKMIAHKFRVTNPQDYGLFLLVDGEEIQLEDNECPQLIKGELLaTSKK 80

                          90
                  ....*....|
gi 453232592 1000 PHMFAYKRHE 1009
Cdd:cd01776    81 PCYFAYKRID 90
VPS9 super family cl19569
Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). ...
 754-868 2.41e-05

Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.


The actual alignment was detected with superfamily member pfam02204:

Pssm-ID: 473191  Cd Length: 104  Bit Score: 44.12  E-value: 2.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232592   754 MEQVKLLMRKMQNHYSPMKKLENLMKAVGLVLGCqVNNGNENEnptdPMSCgyrglppgDDLVRWFVYILSRTSTVGCEV 833
Cdd:pfam02204    1 WEQAQQELKKLNEAKSPREKLKCLLRTCKLITEA-LSKSNRDE----SLGA--------DDLLPILIYVLIRANPPNLYS 67

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 453232592   834 EAWYMWELLpQPIVTQSDASYYLTSLWSAVHVLKS 868
Cdd:pfam02204   68 NLQFISEFR-DPDLLSGEEGYYLTTLEAALEFIES 101
 
Name Accession Description Interval E-value
RA_Rin cd01776
Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family; Family of ...
 921-1009 3.44e-33

Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family; Family of Ras-interaction/interference (Rin) proteins, also known as Ras and Rab interactors, is composed of Rin1, Rin2, and Rin3, which have multifunctional domains, including SH2 and proline-rich domains in the N-terminal region, and RH, VPS9, and RA domains in the C-terminal region. RA domain-containing proteins function by interacting with Ras proteins directly or indirectly and are involved in several different functions ranging from tumor suppression to being oncoproteins. Ras proteins are small GTPases that are involved in cellular signal transduction. The RA domain has the beta-grasp ubiquitin-like (Ubl) fold with low sequence similarity to ubiquitin; ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. The RA domains of Rin1, Rin2, and Rin3 are well conserved and they all have Ras binding characteristics.


Pssm-ID: 340474  Cd Length: 90  Bit Score: 123.17  E-value: 3.44e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232592  921 DAFVKIAVPDEAVGCVRYATFPGVPMLTTSKLSRLVAHQQGITNPEEHGLYLIAEGFESCLSPSECPVLVHEQLK-KDKK 999
Cdd:cd01776     1 QGFLRVAVPDENNGSIVSKTLPVRPSMTAREVCKMIAHKFRVTNPQDYGLFLLVDGEEIQLEDNECPQLIKGELLaTSKK 80

                          90
                  ....*....|
gi 453232592 1000 PHMFAYKRHE 1009
Cdd:cd01776    81 PCYFAYKRID 90
VPS9 pfam02204
Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). ...
 754-868 2.41e-05

Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.


Pssm-ID: 460489  Cd Length: 104  Bit Score: 44.12  E-value: 2.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232592   754 MEQVKLLMRKMQNHYSPMKKLENLMKAVGLVLGCqVNNGNENEnptdPMSCgyrglppgDDLVRWFVYILSRTSTVGCEV 833
Cdd:pfam02204    1 WEQAQQELKKLNEAKSPREKLKCLLRTCKLITEA-LSKSNRDE----SLGA--------DDLLPILIYVLIRANPPNLYS 67

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 453232592   834 EAWYMWELLpQPIVTQSDASYYLTSLWSAVHVLKS 868
Cdd:pfam02204   68 NLQFISEFR-DPDLLSGEEGYYLTTLEAALEFIES 101
VPS9 smart00167
Domain present in VPS9; Domain present in yeast vacuolar sorting protein 9 and other proteins.
 754-868 7.02e-03

Domain present in VPS9; Domain present in yeast vacuolar sorting protein 9 and other proteins.


Pssm-ID: 128469  Cd Length: 117  Bit Score: 37.43  E-value: 7.02e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232592    754 MEQVKLlmrKMQNHY-SPMKKLENLMKAVGLVLGCQVNNGNENenptdpMScgyrglppGDDLVRWFVYILSRTSTVGCE 832
Cdd:smart00167    4 IEQIEL---KFLQLYkSPSDKIKCLLRACKLIYTLLETQSGEV------AG--------ADDFLPVLIYVIIKCDPRDLL 66

                            90       100       110
                    ....*....|....*....|....*....|....*.
gi 453232592    833 VEAWYMWELLPQPIVTQSDAsYYLTSLWSAVHVLKS 868
Cdd:smart00167   67 LNAEYMEEFLEPSLLTGEGG-YYLTSLSAALALIKG 101
 
Name Accession Description Interval E-value
RA_Rin cd01776
Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family; Family of ...
 921-1009 3.44e-33

Ras-associating (RA) domain of Ras and Rab interactor (Rin) protein family; Family of Ras-interaction/interference (Rin) proteins, also known as Ras and Rab interactors, is composed of Rin1, Rin2, and Rin3, which have multifunctional domains, including SH2 and proline-rich domains in the N-terminal region, and RH, VPS9, and RA domains in the C-terminal region. RA domain-containing proteins function by interacting with Ras proteins directly or indirectly and are involved in several different functions ranging from tumor suppression to being oncoproteins. Ras proteins are small GTPases that are involved in cellular signal transduction. The RA domain has the beta-grasp ubiquitin-like (Ubl) fold with low sequence similarity to ubiquitin; ubiquitin is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. The RA domains of Rin1, Rin2, and Rin3 are well conserved and they all have Ras binding characteristics.


Pssm-ID: 340474  Cd Length: 90  Bit Score: 123.17  E-value: 3.44e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232592  921 DAFVKIAVPDEAVGCVRYATFPGVPMLTTSKLSRLVAHQQGITNPEEHGLYLIAEGFESCLSPSECPVLVHEQLK-KDKK 999
Cdd:cd01776     1 QGFLRVAVPDENNGSIVSKTLPVRPSMTAREVCKMIAHKFRVTNPQDYGLFLLVDGEEIQLEDNECPQLIKGELLaTSKK 80

                          90
                  ....*....|
gi 453232592 1000 PHMFAYKRHE 1009
Cdd:cd01776    81 PCYFAYKRID 90
VPS9 pfam02204
Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). ...
 754-868 2.41e-05

Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.


Pssm-ID: 460489  Cd Length: 104  Bit Score: 44.12  E-value: 2.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232592   754 MEQVKLLMRKMQNHYSPMKKLENLMKAVGLVLGCqVNNGNENEnptdPMSCgyrglppgDDLVRWFVYILSRTSTVGCEV 833
Cdd:pfam02204    1 WEQAQQELKKLNEAKSPREKLKCLLRTCKLITEA-LSKSNRDE----SLGA--------DDLLPILIYVLIRANPPNLYS 67

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 453232592   834 EAWYMWELLpQPIVTQSDASYYLTSLWSAVHVLKS 868
Cdd:pfam02204   68 NLQFISEFR-DPDLLSGEEGYYLTTLEAALEFIES 101
RA_Rin2 cd16131
Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2); Rin2, also termed Ras ...
 923-1007 1.54e-03

Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2); Rin2, also termed Ras association domain family 4, or Ras inhibitor JC265, or Ras interaction/interference protein 2, is a Rab5 GDP/GTP exchange factor with the Vps9p-like guanine nucleotide exchange factor and Ras-association (RA) domains. Rin2 connects three GTPases, R-Ras, Rab5 and Rac1, to promote endothelial cell adhesion through the regulation of integrin internalization and Rac1 activation. Rin2 is involved in the regulation of Rab5-mediated early endocytosis. The deficiency of Rin2 can cause the RIN2 syndrome, an autosomal recessive connective tissue disorder.


Pssm-ID: 340548  Cd Length: 91  Bit Score: 38.69  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232592  923 FVKIAVPDEAVGCVRyATFPGVPMLTTSKLSRLVAHQQGITNPEEHGLYLIAEGFESCLSPSECPVLVHEQLKKDKKPHM 1002
Cdd:cd16131     4 YLRVAFQEVNSGCTA-KTLLVRPYTTTEEVCQLCAQKFKVQDPENYSLFLLIDDTWQQLAEDTYPQKIKAELHSRPQPQI 82


                  ....*..
gi 453232592 1003 --FAYKR 1007
Cdd:cd16131    83 fhFVYKR 89
VPS9 smart00167
Domain present in VPS9; Domain present in yeast vacuolar sorting protein 9 and other proteins.
 754-868 7.02e-03

Domain present in VPS9; Domain present in yeast vacuolar sorting protein 9 and other proteins.


Pssm-ID: 128469  Cd Length: 117  Bit Score: 37.43  E-value: 7.02e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 453232592    754 MEQVKLlmrKMQNHY-SPMKKLENLMKAVGLVLGCQVNNGNENenptdpMScgyrglppGDDLVRWFVYILSRTSTVGCE 832
Cdd:smart00167    4 IEQIEL---KFLQLYkSPSDKIKCLLRACKLIYTLLETQSGEV------AG--------ADDFLPVLIYVIIKCDPRDLL 66

                            90       100       110
                    ....*....|....*....|....*....|....*.
gi 453232592    833 VEAWYMWELLPQPIVTQSDAsYYLTSLWSAVHVLKS 868
Cdd:smart00167   67 LNAEYMEEFLEPSLLTGEGG-YYLTSLSAALALIKG 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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