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Conserved domains on  [gi|1409931517|ref|NP_001264797|]
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coronin-1C isoform 1 [Gallus gallus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 114-577 1.03e-110

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 339.95  E-value: 1.03e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 114 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SSFCAVNPRFVAIIVDASGGGAflVLPLHKTGRIDKSYPTVCGHTGPVLDI 192
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 193 DWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVVLEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAl 272
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 273 INLDDMHVDVIYNVSWNRNGSLICTASKDKKVRIIDPRKQEIIAEKEkTHEGARPMRAIFLADGN-IFTTGFSRMSERQL 351
Cdd:PTZ00421  161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 352 ALWNPKNMEEPIALHEMDTSNGVLLPFYDPDTNIIYLCGKGDSSIRYFEITDESPYVHYlnTFSSKEPQRGMGFMPKRGL 431
Cdd:PTZ00421  240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 432 DVNKCEIARFFKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWFEGKNADPLLISLkHGYIPGKNRDLK 509
Cdd:PTZ00421  318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPELM 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 510 VVKKNILDNKPaaNKKSDLISAPKKAADASDTQNEAK----------------LDEILKELKSIKDTITNQDERISKLEQ 573
Cdd:PTZ00421  397 GASALSPSGKP--RHSGVSVPASTSAMTHSFDDNTSKhadpcamgvkrmdegiLDERLGRLQALSEKLRTQHEEIKRCRE 474


                  ....
gi 1409931517 574 QMAK 577
Cdd:PTZ00421  475 ALQK 478
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 114-577 1.03e-110

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 339.95  E-value: 1.03e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 114 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SSFCAVNPRFVAIIVDASGGGAflVLPLHKTGRIDKSYPTVCGHTGPVLDI 192
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 193 DWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVVLEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAl 272
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 273 INLDDMHVDVIYNVSWNRNGSLICTASKDKKVRIIDPRKQEIIAEKEkTHEGARPMRAIFLADGN-IFTTGFSRMSERQL 351
Cdd:PTZ00421  161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 352 ALWNPKNMEEPIALHEMDTSNGVLLPFYDPDTNIIYLCGKGDSSIRYFEITDESPYVHYlnTFSSKEPQRGMGFMPKRGL 431
Cdd:PTZ00421  240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 432 DVNKCEIARFFKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWFEGKNADPLLISLkHGYIPGKNRDLK 509
Cdd:PTZ00421  318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPELM 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 510 VVKKNILDNKPaaNKKSDLISAPKKAADASDTQNEAK----------------LDEILKELKSIKDTITNQDERISKLEQ 573
Cdd:PTZ00421  397 GASALSPSGKP--RHSGVSVPASTSAMTHSFDDNTSKhadpcamgvkrmdegiLDERLGRLQALSEKLRTQHEEIKRCRE 474


                  ....
gi 1409931517 574 QMAK 577
Cdd:PTZ00421  475 ALQK 478
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 109-174 1.40e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 127.62  E-value: 1.40e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1409931517 109 RVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIVDASGGGAFLVLPLHKTGR 174
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 181-406 1.62e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.12  E-value: 1.62e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 181 TVCGHTGPVLDIDWCPHNDQvIASGSEDCTVMVWQipengltLSLTEPVVVLEGHSKRVGIVAWHPTARnVLLSAGCDNA 260
Cdd:cd00200    46 TLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWD-------LETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 261 IIIWNVGTGEALINLDDmHVDVIYNVSWNRNGSLICTASKDKKVRIIDPRKQEIIaekeKTHEG-ARPMRAI-FLADGNI 338
Cdd:cd00200   117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV----ATLTGhTGEVNSVaFSPDGEK 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1409931517 339 FTTGFsrmSERQLALWNPKnMEEPIAL---HEmDTSNGVLlpfYDPDTNIIyLCGKGDSSIRYFEITDESP 406
Cdd:cd00200   192 LLSSS---SDGTIKLWDLS-TGKCLGTlrgHE-NGVNSVA---FSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
184-357 2.05e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 2.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 184 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIpENGltlsltEPVVVLEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 263
Cdd:COG2319   118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATG------KLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 264 WNVGTGEALINLDDmHVDVIYNVSWNRNGSLICTASKDKKVRIIDPRKQEIIaeKEKTHEGARPMRAIFLADGNIFTTGf 343
Cdd:COG2319   189 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASG- 264

                         170
                  ....*....|....
gi 1409931517 344 srMSERQLALWNPK 357
Cdd:COG2319   265 --SADGTVRLWDLA 276
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 184-214 4.75e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 4.75e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1409931517  184 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 214
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 114-577 1.03e-110

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 339.95  E-value: 1.03e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 114 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SSFCAVNPRFVAIIVDASGGGAflVLPLHKTGRIDKSYPTVCGHTGPVLDI 192
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 193 DWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVVLEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAl 272
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 273 INLDDMHVDVIYNVSWNRNGSLICTASKDKKVRIIDPRKQEIIAEKEkTHEGARPMRAIFLADGN-IFTTGFSRMSERQL 351
Cdd:PTZ00421  161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 352 ALWNPKNMEEPIALHEMDTSNGVLLPFYDPDTNIIYLCGKGDSSIRYFEITDESPYVHYlnTFSSKEPQRGMGFMPKRGL 431
Cdd:PTZ00421  240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 432 DVNKCEIARFFKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWFEGKNADPLLISLkHGYIPGKNRDLK 509
Cdd:PTZ00421  318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPELM 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 510 VVKKNILDNKPaaNKKSDLISAPKKAADASDTQNEAK----------------LDEILKELKSIKDTITNQDERISKLEQ 573
Cdd:PTZ00421  397 GASALSPSGKP--RHSGVSVPASTSAMTHSFDDNTSKhadpcamgvkrmdegiLDERLGRLQALSEKLRTQHEEIKRCRE 474


                  ....
gi 1409931517 574 QMAK 577
Cdd:PTZ00421  475 ALQK 478
PTZ00420 PTZ00420
coronin; Provisional
 130-513 2.25e-65

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 223.67  E-value: 2.25e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 130 YDDIRV-SRVTwDSSFCAVNPRFVAIIVDASGGGAFLVLPLHKTGRidksYPTVC---GHTGPVLDIDWCPHNDQVIASG 205
Cdd:PTZ00420   19 FDDLRIcSRVI-DSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR----KPPVIklkGHTSSILDLQFNPCFSEILASG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 206 SEDCTVMVWQIPENGLTLS-LTEPVVVLEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAL--INLDDMhvdv 282
Cdd:PTZ00420   94 SEDLTIRVWEIPHNDESVKeIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAfqINMPKK---- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 283 IYNVSWNRNGSLICTASKDKKVRIIDPRKQEIiAEKEKTHEGARPMRAIFL-----ADGNIFTTGFSRMSERQLALWNPK 357
Cdd:PTZ00420  170 LSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEI-ASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMKLWDLK 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 358 NMEEPIALHEMDTSNGVLLPFYDPDTNIIYLCGKGDSSIRYFEITDESpyVHYLNTFSSKEPQRGMGFMPKRGLDVNKCE 437
Cdd:PTZ00420  249 NTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCE 326

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1409931517 438 IARFFK-LHERKCEPIIMTVPRK-SDLFQDDLYPDTAGPEAALEAEEWFEGKNADPLLISLKHgyipGKNRDLKVVKK 513
Cdd:PTZ00420  327 IGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKD----LTEDDLRITKK 400
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 109-174 1.40e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 127.62  E-value: 1.40e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1409931517 109 RVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIVDASGGGAFLVLPLHKTGR 174
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 181-406 1.62e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.12  E-value: 1.62e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 181 TVCGHTGPVLDIDWCPHNDQvIASGSEDCTVMVWQipengltLSLTEPVVVLEGHSKRVGIVAWHPTARnVLLSAGCDNA 260
Cdd:cd00200    46 TLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWD-------LETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 261 IIIWNVGTGEALINLDDmHVDVIYNVSWNRNGSLICTASKDKKVRIIDPRKQEIIaekeKTHEG-ARPMRAI-FLADGNI 338
Cdd:cd00200   117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV----ATLTGhTGEVNSVaFSPDGEK 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1409931517 339 FTTGFsrmSERQLALWNPKnMEEPIAL---HEmDTSNGVLlpfYDPDTNIIyLCGKGDSSIRYFEITDESP 406
Cdd:cd00200   192 LLSSS---SDGTIKLWDLS-TGKCLGTlrgHE-NGVNSVA---FSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
184-357 2.05e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 2.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 184 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIpENGltlsltEPVVVLEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 263
Cdd:COG2319   118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATG------KLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 264 WNVGTGEALINLDDmHVDVIYNVSWNRNGSLICTASKDKKVRIIDPRKQEIIaeKEKTHEGARPMRAIFLADGNIFTTGf 343
Cdd:COG2319   189 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASG- 264

                         170
                  ....*....|....
gi 1409931517 344 srMSERQLALWNPK 357
Cdd:COG2319   265 --SADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
184-358 2.37e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.60  E-value: 2.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 184 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVVLEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 263
Cdd:COG2319   244 GHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRL 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 264 WNVGTGEALINLDDmHVDVIYNVSWNRNGSLICTASKDKKVRIIDPRKQEIIAEKeKTHEGArPMRAIFLADGNIFTTGf 343
Cdd:COG2319   315 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-TGHTGA-VTSVAFSPDGRTLASG- 390

                         170
                  ....*....|....*
gi 1409931517 344 SRmsERQLALWNPKN 358
Cdd:COG2319   391 SA--DGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 184-317 5.19e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 5.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 184 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVVLEGHSKRVGIVAWHPTARNvLLSAGCDNAIII 263
Cdd:cd00200   133 GHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTG-------KCVATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIKL 203

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1409931517 264 WNVGTGEALINLDDmHVDVIYNVSWNRNGSLICTASKDKKVRIIDPRKQEIIAE 317
Cdd:cd00200   204 WDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT 256
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 449-491 5.94e-21

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 86.03  E-value: 5.94e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1409931517 449 CEPIIMTVPRKS-DLFQDDLYPDTAGPEAALEAEEWFEGKNADP 491
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 184-306 7.35e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.31  E-value: 7.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 184 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQipengltLSLTEPVVVLEGHSKRVGIVAWHPTaRNVLLSAGCDNAIII 263
Cdd:cd00200   175 GHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWD-------LSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRV 245

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1409931517 264 WNVGTGEALINLDdMHVDVIYNVSWNRNGSLICTASKDKKVRI 306
Cdd:cd00200   246 WDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 231-406 1.67e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 1.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 231 VLEGHSKRVGIVAWHPTaRNVLLSAGCDNAIIIWNVGTGEALINLDDmHVDVIYNVSWNRNGSLICTASKDKKVRIIDPR 310
Cdd:cd00200     4 TLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 311 KQEIIAEKEkTHEGarPMRAI-FLADGNIFTTGfsrMSERQLALWNPKNMEEPIAL--HEMDTSNGVllpfYDPDTNIIY 387
Cdd:cd00200    82 TGECVRTLT-GHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWDVETGKCLTTLrgHTDWVNSVA----FSPDGTFVA 151

                         170
                  ....*....|....*....
gi 1409931517 388 lCGKGDSSIRYFEITDESP 406
Cdd:cd00200   152 -SSSQDGTIKLWDLRTGKC 169
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 184-214 4.75e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 4.75e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1409931517  184 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 214
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
181-214 3.23e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 3.23e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1409931517 181 TVCGHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 214
Cdd:pfam00400   6 TLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 227-265 4.78e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.78e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1409931517  227 EPVVVLEGHSKRVGIVAWHPTaRNVLLSAGCDNAIIIWN 265
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
227-265 2.41e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 2.41e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1409931517 227 EPVVVLEGHSKRVGIVAWHPTaRNVLLSAGCDNAIIIWN 265
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-215 2.50e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 2.50e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1409931517 171 KTGRIDKsypTVCGHTGPVLDIDWCPHNdQVIASGSEDCTVMVWQ 215
Cdd:cd00200   249 RTGECVQ---TLSGHTNSVTSLAWSPDG-KRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 279-308 4.59e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 4.59e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1409931517  279 HVDVIYNVSWNRNGSLICTASKDKKVRIID 308
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
279-308 1.79e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.79e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1409931517 279 HVDVIYNVSWNRNGSLICTASKDKKVRIID 308
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
TOPEUc smart00435
DNA Topoisomerase I (eukaryota); DNA Topoisomerase I (eukaryota), DNA topoisomerase V, Vaccina ...
 501-575 6.59e-03

DNA Topoisomerase I (eukaryota); DNA Topoisomerase I (eukaryota), DNA topoisomerase V, Vaccina virus topoisomerase, Variola virus topoisomerase, Shope fibroma virus topoisomeras


Pssm-ID: 214661 [Multi-domain]  Cd Length: 391  Bit Score: 39.25  E-value: 6.59e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1409931517  501 IPGKNRDLKVVKKNILDNKPAANKKSDLISAPKKAADASDTQNEAKLDEILKELKSiKDTITNQDERISKLEQQM 575
Cdd:smart00435 286 IKALKYQLKRLKKMILLFEMISDLKRKLKSKFERDNEKLDAEVKEKKKEKKKEEKK-KKQIERLEERIEKLEVQA 359
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 194-291 6.78e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.10  E-value: 6.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409931517 194 WCPHNDqVIASGSEDCTV--------MVWQIPengltlsltepvvvLEGHSKRVGIVAWHPTARnVLLSAGCDNAIIIWN 265
Cdd:pfam12894   3 WCPTMD-LIALATEDGELllhrlnwqRVWTLS--------------PDKEDLEVTSLAWRPDGK-LLAVGYSDGTVRLLD 66

                          90       100
                  ....*....|....*....|....*.
gi 1409931517 266 VGTGEALINLdDMHVDVIYNVSWNRN 291
Cdd:pfam12894  67 AENGKIVHHF-SAGSDLITCLGWGEN 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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