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Conserved domains on  [gi|497241795|ref|NP_001265074|]
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1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Gallus gallus]

Protein Classification

alpha/beta hydrolase domain-containing protein( domain architecture ID 1005082)

alpha/beta hydrolase (abhydrolase) domain-containing protein

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02894 super family cl30398
hydrolase, alpha/beta fold family protein
 38-365 1.05e-55

hydrolase, alpha/beta fold family protein


The actual alignment was detected with superfamily member PLN02894:

Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 187.42  E-value: 1.05e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  38 GWLFSWLpAWCPTSLLHLKEAEDKMLKCITSTYNKRYVYLANG----------------NKIWTLTFSPDLSRKTpLVLL 101
Cdd:PLN02894  34 SLWPSPL-RWIPTSTDHIIAAEKRLLSLVKTPYVQEQVNIGSGppgskvrwfrsasnepRFINTVTFDSKEDAPT-LVMV 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795 102 HGFGGGVGMWALNFEELCENRTVHAFDLLGFGRSSRPHFDTDARE-AENQFVESIEEWRKEMGLEKMILLGHNLGGFLAA 180
Cdd:PLN02894 112 HGYGASQGFFFRNFDALASRFRVIAIDQLGWGGSSRPDFTCKSTEeTEAWFIDSFEEWRKAKNLSNFILLGHSFGGYVAA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795 181 AYSLKYPSRVKHLILVEPWGFPERPDNAEhERPIPIWIKALGAIL-----SPFNPLAGLRIAGPFGLSLVQRLRPDFKRK 255
Cdd:PLN02894 192 KYALKHPEHVQHLILVGPAGFSSESDDKS-EWLTKFRATWKGAVLnhlweSNFTPQKIIRGLGPWGPNLVRRYTTARFGA 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795 256 YA-----SMFDDNTVTEYIYHCNVQSPSGETAFKNMTIPYGWAKRPMLQRIPQMdqDIPITVVYGARSCIDgNSGSTIQS 330
Cdd:PLN02894 271 HStgdilSEEESKLLTDYVYHTLAAKASGELCLKYIFSFGAFARKPLLESASEW--KVPTTFIYGRHDWMN-YEGAVEAR 347

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 497241795 331 LRPKSYVKTIAILGAGHYVYADQPEDFNQKVKDIC 365
Cdd:PLN02894 348 KRMKVPCEIIRVPQGGHFVFLDNPSGFHSAVLYAC 382
 
Name Accession Description Interval E-value
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 38-365 1.05e-55

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 187.42  E-value: 1.05e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  38 GWLFSWLpAWCPTSLLHLKEAEDKMLKCITSTYNKRYVYLANG----------------NKIWTLTFSPDLSRKTpLVLL 101
Cdd:PLN02894  34 SLWPSPL-RWIPTSTDHIIAAEKRLLSLVKTPYVQEQVNIGSGppgskvrwfrsasnepRFINTVTFDSKEDAPT-LVMV 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795 102 HGFGGGVGMWALNFEELCENRTVHAFDLLGFGRSSRPHFDTDARE-AENQFVESIEEWRKEMGLEKMILLGHNLGGFLAA 180
Cdd:PLN02894 112 HGYGASQGFFFRNFDALASRFRVIAIDQLGWGGSSRPDFTCKSTEeTEAWFIDSFEEWRKAKNLSNFILLGHSFGGYVAA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795 181 AYSLKYPSRVKHLILVEPWGFPERPDNAEhERPIPIWIKALGAIL-----SPFNPLAGLRIAGPFGLSLVQRLRPDFKRK 255
Cdd:PLN02894 192 KYALKHPEHVQHLILVGPAGFSSESDDKS-EWLTKFRATWKGAVLnhlweSNFTPQKIIRGLGPWGPNLVRRYTTARFGA 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795 256 YA-----SMFDDNTVTEYIYHCNVQSPSGETAFKNMTIPYGWAKRPMLQRIPQMdqDIPITVVYGARSCIDgNSGSTIQS 330
Cdd:PLN02894 271 HStgdilSEEESKLLTDYVYHTLAAKASGELCLKYIFSFGAFARKPLLESASEW--KVPTTFIYGRHDWMN-YEGAVEAR 347

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 497241795 331 LRPKSYVKTIAILGAGHYVYADQPEDFNQKVKDIC 365
Cdd:PLN02894 348 KRMKVPCEIIRVPQGGHFVFLDNPSGFHSAVLYAC 382
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 96-354 5.80e-28

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 109.90  E-value: 5.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795   96 TPLVLLHGFGGGVGMWALNFEELCENR-TVHAFDLLGFGRSSRPHFDTDAREAEnqFVESIEEWRKEMGLEKMILLGHNL 174
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDGfRVIALDLRGFGKSSRPKAQDDYRTDD--LAEDLEYILEALGLEKVNLVGHSM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  175 GGFLAAAYSLKYPSRVKHLILVEPWG-FPERPDNAEHERPIPIWIK---ALGAILSPFNPLAGLRIAGPFGLSLVQRLRP 250
Cdd:pfam00561  79 GGLIALAYAAKYPDRVKALVLLGALDpPHELDEADRFILALFPGFFdgfVADFAPNPLGRLVAKLLALLLLRLRLLKALP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  251 DFKRKYASMFDDN---TVTEYIYHCNvqspsgetafknmtipyGWAKRPMLQRIPQmdQDIPITVVYGARSCIDGNSGST 327
Cdd:pfam00561 159 LLNKRFPSGDYALaksLVTGALLFIE-----------------TWSTELRAKFLGR--LDEPTLIIWGDQDPLVPPQALE 219

                         250       260
                  ....*....|....*....|....*...
gi 497241795  328 -IQSLRPKSYVKTIAilGAGHYVYADQP 354
Cdd:pfam00561 220 kLAQLFPNARLVVIP--DAGHFAFLEGP 245
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 78-368 3.72e-27

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 107.01  E-value: 3.72e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  78 ANGNKIWTLTFSPDlsrKTPLVLLHGFGGGVGMWALNFEELCENRTVHAFDLLGFGRSSRPHFDTDAReaenQFVESIEE 157
Cdd:COG0596    9 VDGVRLHYREAGPD---GPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTLD----DLADDLAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795 158 WRKEMGLEKMILLGHNLGGFLAAAYSLKYPSRVKHLILVepwgfperpdnaeherpipiwikalgailspfnplaglria 237
Cdd:COG0596   82 LLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLV----------------------------------------- 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795 238 gpfglslvqrlrpdfkrkyasmfdDNTVTEYIYHCNVQSPSGETAFKNMTIPYGWAKRPMLQRIpqmdqDIPITVVYGAR 317
Cdd:COG0596  121 ------------------------DEVLAALAEPLRRPGLAPEALAALLRALARTDLRERLARI-----TVPTLVIWGEK 171

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 497241795 318 S-CIDGNSGSTIQSLRPKSYVKTIAilGAGHYVYADQPEDFNQKVKDICDSV 368
Cdd:COG0596  172 DpIVPPALARRLAELLPNAELVVLP--GAGHFPPLEQPEAFAAALRDFLARL 221
Esterase_713_like-1 cd12808
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 168-215 2.72e-04

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214007  Cd Length: 309  Bit Score: 42.23  E-value: 2.72e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 497241795 168 ILLGHNLGGFLAAAYSLKYPSRVKHLILVEPWGFPERPDNAEHeRPIP 215
Cdd:cd12808  191 IVVAHSQGGGFAFEAARARPDLVRAVVALEPSGAPDPAEAAPL-ADVP 237
 
Name Accession Description Interval E-value
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 38-365 1.05e-55

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 187.42  E-value: 1.05e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  38 GWLFSWLpAWCPTSLLHLKEAEDKMLKCITSTYNKRYVYLANG----------------NKIWTLTFSPDLSRKTpLVLL 101
Cdd:PLN02894  34 SLWPSPL-RWIPTSTDHIIAAEKRLLSLVKTPYVQEQVNIGSGppgskvrwfrsasnepRFINTVTFDSKEDAPT-LVMV 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795 102 HGFGGGVGMWALNFEELCENRTVHAFDLLGFGRSSRPHFDTDARE-AENQFVESIEEWRKEMGLEKMILLGHNLGGFLAA 180
Cdd:PLN02894 112 HGYGASQGFFFRNFDALASRFRVIAIDQLGWGGSSRPDFTCKSTEeTEAWFIDSFEEWRKAKNLSNFILLGHSFGGYVAA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795 181 AYSLKYPSRVKHLILVEPWGFPERPDNAEhERPIPIWIKALGAIL-----SPFNPLAGLRIAGPFGLSLVQRLRPDFKRK 255
Cdd:PLN02894 192 KYALKHPEHVQHLILVGPAGFSSESDDKS-EWLTKFRATWKGAVLnhlweSNFTPQKIIRGLGPWGPNLVRRYTTARFGA 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795 256 YA-----SMFDDNTVTEYIYHCNVQSPSGETAFKNMTIPYGWAKRPMLQRIPQMdqDIPITVVYGARSCIDgNSGSTIQS 330
Cdd:PLN02894 271 HStgdilSEEESKLLTDYVYHTLAAKASGELCLKYIFSFGAFARKPLLESASEW--KVPTTFIYGRHDWMN-YEGAVEAR 347

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 497241795 331 LRPKSYVKTIAILGAGHYVYADQPEDFNQKVKDIC 365
Cdd:PLN02894 348 KRMKVPCEIIRVPQGGHFVFLDNPSGFHSAVLYAC 382
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 96-354 5.80e-28

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 109.90  E-value: 5.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795   96 TPLVLLHGFGGGVGMWALNFEELCENR-TVHAFDLLGFGRSSRPHFDTDAREAEnqFVESIEEWRKEMGLEKMILLGHNL 174
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDGfRVIALDLRGFGKSSRPKAQDDYRTDD--LAEDLEYILEALGLEKVNLVGHSM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  175 GGFLAAAYSLKYPSRVKHLILVEPWG-FPERPDNAEHERPIPIWIK---ALGAILSPFNPLAGLRIAGPFGLSLVQRLRP 250
Cdd:pfam00561  79 GGLIALAYAAKYPDRVKALVLLGALDpPHELDEADRFILALFPGFFdgfVADFAPNPLGRLVAKLLALLLLRLRLLKALP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  251 DFKRKYASMFDDN---TVTEYIYHCNvqspsgetafknmtipyGWAKRPMLQRIPQmdQDIPITVVYGARSCIDGNSGST 327
Cdd:pfam00561 159 LLNKRFPSGDYALaksLVTGALLFIE-----------------TWSTELRAKFLGR--LDEPTLIIWGDQDPLVPPQALE 219

                         250       260
                  ....*....|....*....|....*...
gi 497241795  328 -IQSLRPKSYVKTIAilGAGHYVYADQP 354
Cdd:pfam00561 220 kLAQLFPNARLVVIP--DAGHFAFLEGP 245
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 78-368 3.72e-27

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 107.01  E-value: 3.72e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  78 ANGNKIWTLTFSPDlsrKTPLVLLHGFGGGVGMWALNFEELCENRTVHAFDLLGFGRSSRPHFDTDAReaenQFVESIEE 157
Cdd:COG0596    9 VDGVRLHYREAGPD---GPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTLD----DLADDLAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795 158 WRKEMGLEKMILLGHNLGGFLAAAYSLKYPSRVKHLILVepwgfperpdnaeherpipiwikalgailspfnplaglria 237
Cdd:COG0596   82 LLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLV----------------------------------------- 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795 238 gpfglslvqrlrpdfkrkyasmfdDNTVTEYIYHCNVQSPSGETAFKNMTIPYGWAKRPMLQRIpqmdqDIPITVVYGAR 317
Cdd:COG0596  121 ------------------------DEVLAALAEPLRRPGLAPEALAALLRALARTDLRERLARI-----TVPTLVIWGEK 171

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 497241795 318 S-CIDGNSGSTIQSLRPKSYVKTIAilGAGHYVYADQPEDFNQKVKDICDSV 368
Cdd:COG0596  172 DpIVPPALARRLAELLPNAELVVLP--GAGHFPPLEQPEAFAAALRDFLARL 221
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 96-201 3.57e-18

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 84.61  E-value: 3.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  96 TPLVLLHGFGGGVGMWALNFEELCENRTVHAFDLLGFGRSSRPHFDTDAREaenqFVESIEEWRKEMGLEKMILLGHNLG 175
Cdd:PRK14875 132 TPVVLIHGFGGDLNNWLFNHAALAAGRPVIALDLPGHGASSKAVGAGSLDE----LAAAVLAFLDALGIERAHLVGHSMG 207

                         90       100
                 ....*....|....*....|....*.
gi 497241795 176 GFLAAAYSLKYPSRVKHLILVEPWGF 201
Cdd:PRK14875 208 GAVALRLAARAPQRVASLTLIAPAGL 233
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
78-199 7.96e-18

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 81.20  E-value: 7.96e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  78 ANGNKIWTLTFSPDLSRKTPLVLLHGFGGGVGMWALNFEELCENR-TVHAFDLLGFGRSSRPH-FDTDAREAENQFVESI 155
Cdd:COG2267   11 RDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSGRYAELAEALAAAGyAVLAFDLRGHGRSDGPRgHVDSFDDYVDDLRAAL 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 497241795 156 EEWRKEMGLeKMILLGHNLGGFLAAAYSLKYPSRVKHLILVEPW 199
Cdd:COG2267   91 DALRARPGL-PVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPA 133
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 98-258 1.63e-15

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 74.94  E-value: 1.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795   98 LVLLHGFGGGVGmwalNFEELCE-----NRTVHAFDLLGFGRSSR-----PHFDT---DAReaenQFVESIeewRKEMGL 164
Cdd:pfam12146   7 VVLVHGLGEHSG----RYAHLADalaaqGFAVYAYDHRGHGRSDGkrghvPSFDDyvdDLD----TFVDKI---REEHPG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  165 EKMILLGHNLGGFLAAAYSLKYPSRVKHLILVEPWGFPerpdnaeHERPIPIWIKALGAILSPFNPlaGLRIAGPFGLSL 244
Cdd:pfam12146  76 LPLFLLGHSMGGLIAALYALRYPDKVDGLILSAPALKI-------KPYLAPPILKLLAKLLGKLFP--RLRVPNNLLPDS 146

                         170
                  ....*....|....
gi 497241795  245 VQRlRPDFKRKYAS 258
Cdd:pfam12146 147 LSR-DPEVVAAYAA 159
PLN02578 PLN02578
hydrolase
 97-200 4.51e-14

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 72.57  E-value: 4.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  97 PLVLLHGFGGGVGMWALNFEELCENRTVHAFDLLGFGRSSRPHFDTDAREAENQfvesIEEWRKEMGLEKMILLGHNLGG 176
Cdd:PLN02578  88 PIVLIHGFGASAFHWRYNIPELAKKYKVYALDLLGFGWSDKALIEYDAMVWRDQ----VADFVKEVVKEPAVLVGNSLGG 163

                         90       100
                 ....*....|....*....|....
gi 497241795 177 FLAAAYSLKYPSRVKHLILVEPWG 200
Cdd:PLN02578 164 FTALSTAVGYPELVAGVALLNSAG 187
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 98-359 2.12e-10

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 59.79  E-value: 2.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795   98 LVLLHGFGGGVGMWAlnfEELCENRTVHAFDLLGFGRSSRPHFDTDAREAENQFVESIEEWRKEmglekmILLGHNLGGF 177
Cdd:pfam12697   1 VVLVHGAGLSAAPLA---ALLAAGVAVLAPDLPGHGSSSPPPLDLADLADLAALLDELGAARPV------VLVGHSLGGA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  178 LAAAYSlkyPSRVKHLILVEPWGFPERpdnaeHERPIPIWIKALGAILspfnplaglriaGPFGLSLVQRLRPDfkrkya 257
Cdd:pfam12697  72 VALAAA---AAALVVGVLVAPLAAPPG-----LLAALLALLARLGAAL------------AAPAWLAAESLARG------ 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  258 smFDDNTVTEYIYHCNVQSPSGETAFKNMTIPYGWAKRPmlqripqmdqdIPITVVYGArsciDGNSGSTIQ-SLRPKSY 336
Cdd:pfam12697 126 --FLDDLPADAEWAAALARLAALLAALALLPLAAWRDLP-----------VPVLVLAEE----DRLVPELAQrLLAALAG 188

                         250       260
                  ....*....|....*....|...
gi 497241795  337 VKTIAILGAGHYVYaDQPEDFNQ 359
Cdd:pfam12697 189 ARLVVLPGAGHLPL-DDPEEVAE 210
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 93-196 2.67e-10

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 57.15  E-value: 2.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  93 SRKTPLVLLHGFGGGVGMWALNFEELCEN-RTVHAFDLlgfgrssrPHFDTDAREAENQFVESIEEWRKEMGLEKMILLG 171
Cdd:COG1075    3 ATRYPVVLVHGLGGSAASWAPLAPRLRAAgYPVYALNY--------PSTNGSIEDSAEQLAAFVDAVLAATGAEKVDLVG 74

                         90       100
                 ....*....|....*....|....*..
gi 497241795 172 HNLGGFLAAAY--SLKYPSRVKHLILV 196
Cdd:COG1075   75 HSMGGLVARYYlkRLGGAAKVARVVTL 101
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
81-196 8.61e-10

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 58.88  E-value: 8.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  81 NKIWTLTFSpdlSRKTPLVLLHGFGGGVGMWALNFEELCENRTVHAFDLLGFGRSSrpHFDTDAreaenqfVESIEEWRK 160
Cdd:PRK10349   2 NNIWWQTKG---QGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSR--GFGALS-------LADMAEAVL 69

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 497241795 161 EMGLEKMILLGHNLGGFLAAAYSLKYPSRVKHLILV 196
Cdd:PRK10349  70 QQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTV 105
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 89-138 7.41e-09

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 56.77  E-value: 7.41e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 497241795  89 SPDLSRKTPLVLL-HGFGGGVGMWALNFEELCENRTVHAFDLLGFGRSSRP 138
Cdd:PLN02679  81 SPEVTSSGPPVLLvHGFGASIPHWRRNIGVLAKNYTVYAIDLLGFGASDKP 131
PLN03087 PLN03087
BODYGUARD 1 domain containing hydrolase; Provisional
 90-202 1.09e-08

BODYGUARD 1 domain containing hydrolase; Provisional


Pssm-ID: 215567  Cd Length: 481  Bit Score: 56.36  E-value: 1.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  90 PDLSRKTPLVLLHGFGGGVGMWAL----NFEELCE-NRTVHAFDLLGFGRSSRPhfdTDAREAENQFVESIEEWRKE-MG 163
Cdd:PLN03087 196 KDNKAKEDVLFIHGFISSSAFWTEtlfpNFSDAAKsTYRLFAVDLLGFGRSPKP---ADSLYTLREHLEMIERSVLErYK 272

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 497241795 164 LEKMILLGHNLGGFLAAAYSLKYPSRVKHLILVEPWGFP 202
Cdd:PLN03087 273 VKSFHIVAHSLGCILALALAVKHPGAVKSLTLLAPPYYP 311
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
99-369 1.08e-07

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 52.25  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  99 VLLHGFGGG---VGMWALNFEElcENRTVHAFDLLGFGRSSRPHFDTDAREAENQFVESIEEWRKEMglEKMILLGHNLG 175
Cdd:COG1647   19 LLLHGFTGSpaeMRPLAEALAK--AGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKAGY--DKVIVIGLSMG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795 176 GFLAAAYSLKYPsRVKHLILVEPwgfperpdnaeherpiPIWIKALGAILSPFnplaglriagpfglslVQRLRPdFKRK 255
Cdd:COG1647   95 GLLALLLAARYP-DVAGLVLLSP----------------ALKIDDPSAPLLPL----------------LKYLAR-SLRG 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795 256 YASMFDDNTVTEYIYHCNVQSpsgetAFKNMTIPYGWAKRPmLQRIpqmdqDIPITVVYGAR-SCIDGNSGSTIQSLRPK 334
Cdd:COG1647  141 IGSDIEDPEVAEYAYDRTPLR-----ALAELQRLIREVRRD-LPKI-----TAPTLIIQSRKdEVVPPESARYIYERLGS 209

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 497241795 335 SYVKTIAILGAGHYVYAD-QPEDFNQKVKDICDSVD 369
Cdd:COG1647  210 PDKELVWLEDSGHVITLDkDREEVAEEILDFLERLA 245
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 96-198 1.10e-07

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 52.82  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  96 TPLVLLHGFGGGVGMWALNFEELCENRTVHAFDLLGFGRSSRPhfdtDAREAENQFVESIEEWRKEMGL-------EKMI 168
Cdd:PLN02824  30 PALVLVHGFGGNADHWRKNTPVLAKSHRVYAIDLLGYGYSDKP----NPRSAPPNSFYTFETWGEQLNDfcsdvvgDPAF 105

                         90       100       110
                 ....*....|....*....|....*....|
gi 497241795 169 LLGHNLGGFLAAAYSLKYPSRVKHLILVEP 198
Cdd:PLN02824 106 VICNSVGGVVGLQAAVDAPELVRGVMLINI 135
YpfH COG0400
Predicted esterase [General function prediction only];
98-218 4.65e-07

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 49.91  E-value: 4.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  98 LVLLHGFGG-GVGMWALnFEELCENRT----VHA-----------FDLLGFGRSSRPhfdTDAREAENQFVESIEEWRKE 161
Cdd:COG0400    8 VVLLHGYGGdEEDLLPL-APELALPGAavlaPRApvpegpggrawFDLSFLEGREDE---EGLAAAAEALAAFIDELEAR 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 497241795 162 MGL--EKMILLGHNLGGFLAAAYSLKYPSRVKHLILVEPwGFPERPDNAEHE---RPIPIWI 218
Cdd:COG0400   84 YGIdpERIVLAGFSQGAAMALSLALRRPELLAGVVALSG-YLPGEEALPAPEaalAGTPVFL 144
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 97-210 7.18e-06

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 47.57  E-value: 7.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  97 PLVLLHGFGGGVGMWALNFEELCENRTVHAFDLLGFGRSSRPHFDTDAREAENQFVESIEEWRKEMGLEKMILLGHnlGG 176
Cdd:PLN03084 129 PVLLIHGFPSQAYSYRKVLPVLSKNYHAIAFDWLGFGFSDKPQPGYGFNYTLDEYVSSLESLIDELKSDKVSLVVQ--GY 206

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 497241795 177 FLAAA--YSLKYPSRVKHLILVEPwgfperPDNAEH 210
Cdd:PLN03084 207 FSPPVvkYASAHPDKIKKLILLNP------PLTKEH 236
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
78-196 2.17e-05

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 45.39  E-value: 2.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  78 ANGNKIWTLTFSPDLSRKTPLVLL-HGFGGG-VGMWALNFEELCENR-TVHAFDLLGFGRSSRPHFDTDAREAEN--QFV 152
Cdd:COG1506    5 ADGTTLPGWLYLPADGKKYPVVVYvHGGPGSrDDSFLPLAQALASRGyAVLAPDYRGYGESAGDWGGDEVDDVLAaiDYL 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 497241795 153 ESieewRKEMGLEKMILLGHNLGGFLAAAYSLKYPSRVKHLILV 196
Cdd:COG1506   85 AA----RPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVAL 124
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 97-198 8.46e-05

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 43.83  E-value: 8.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  97 PLVLLHGFGGGVGMWALNFEELCENRTVHAFDLLGFGRSSRPhfDTDAREAENqfVESIEEWRKEMGLEKMILLGHNLGG 176
Cdd:PRK03592  29 PIVFLHGNPTSSYLWRNIIPHLAGLGRCLAPDLIGMGASDKP--DIDYTFADH--ARYLDAWFDALGLDDVVLVGHDWGS 104

                         90       100
                 ....*....|....*....|..
gi 497241795 177 FLAAAYSLKYPSRVKHLILVEP 198
Cdd:PRK03592 105 ALGFDWAARHPDRVRGIAFMEA 126
Esterase_713_like-1 cd12808
Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated ...
 168-215 2.72e-04

Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; This family contains uncharacterized proteins similar to a novel bacterial esterase (Alcaligenes esterase 713) with the alpha/beta hydrolase fold but does not contain the GXSXXG pentapeptide around the active site serine residue as commonly seen in other enzymes of this class. Esterase 713 shows negligible sequence homology to other esterase and lipase enzymes. It is active as a dimer and cleaves esters on halogenated cyclic compounds though its natural substrate is unknown.


Pssm-ID: 214007  Cd Length: 309  Bit Score: 42.23  E-value: 2.72e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 497241795 168 ILLGHNLGGFLAAAYSLKYPSRVKHLILVEPWGFPERPDNAEHeRPIP 215
Cdd:cd12808  191 IVVAHSQGGGFAFEAARARPDLVRAVVALEPSGAPDPAEAAPL-ADVP 237
PRK10673 PRK10673
esterase;
95-197 2.30e-03

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 39.33  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  95 KTPLVLLHGFGGGVGMWALNFEELCENRTVHAFDLLGFGRSSR-PHFDTDAreaenqFVESIEEWRKEMGLEKMILLGHN 173
Cdd:PRK10673  16 NSPIVLVHGLFGSLDNLGVLARDLVNDHDIIQVDMRNHGLSPRdPVMNYPA------MAQDLLDTLDALQIEKATFIGHS 89

                         90       100
                 ....*....|....*....|....
gi 497241795 174 LGGFLAAAYSLKYPSRVKHLILVE 197
Cdd:PRK10673  90 MGGKAVMALTALAPDRIDKLVAID 113
EntF2 COG3319
Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase ...
 93-249 2.75e-03

Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442548 [Multi-domain]  Cd Length: 855  Bit Score: 39.69  E-value: 2.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  93 SRKTPLVLLHGFGGGVgmwaLNFEEL----CENRTVHAFDLLGFGRSSRPHFDTDAReAEnQFVESIEEWRKEmglEKMI 168
Cdd:COG3319  599 GSGPPLFCVHPAGGNV----LCYRPLaralGPDRPVYGLQAPGLDGGEPPPASVEEM-AA-RYVEAIRAVQPE---GPYH 669

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795 169 LLGHNLGGFLA--AAYSLKypSR---VKHLILVEPWGfPERPDNAEHERPIPIWIKALGAILSPFNPLAGLRiagpfGLS 243
Cdd:COG3319  670 LLGWSFGGLVAyeMARQLE--AQgeeVALLVLLDSYA-PGALARLDEAELLAALLRDLARGVDLPLDAEELR-----ALD 741


                 ....*.
gi 497241795 244 LVQRLR 249
Cdd:COG3319  742 PEERLA 747
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 98-237 3.43e-03

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 38.74  E-value: 3.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 497241795  98 LVLLHGFGGGVGMWALNFEELCENR-TVHAFDLLGFGRSS-RPHF--DTDAREAEN--QFVESIEEWRKemglEKMILLG 171
Cdd:COG1073   40 VVVAHGNGGVKEQRALYAQRLAELGfNVLAFDYRGYGESEgEPREegSPERRDARAavDYLRTLPGVDP----ERIGLLG 115

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 497241795 172 HNLGGFLAAAYSLKYPsRVKHLILVEPwgFPERPDNAEHerpipIWIKALGAILSPFNPLAGLRIA 237
Cdd:COG1073  116 ISLGGGYALNAAATDP-RVKAVILDSP--FTSLEDLAAQ-----RAKEARGAYLPGVPYLPNVRLA 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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