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Conserved domains on  [gi|522022831|ref|NP_001265602|]
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nuclear factor of activated T-cells, cytoplasmic 1 isoform J [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RHD-n super family cl08275
N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology ...
 1-118 3.97e-85

N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal sub-domain, which may be distantly related to the DNA-binding domain found in P53. The C-terminal sub-domain has an immunoglobulin-like fold and serves as a dimerization module that also binds DNA (see cd00102). The RHD is found in NF-kappa B, nuclear factor of activated T-cells (NFAT), the tonicity-responsive enhancer binding protein (TonEBP), and the arthropod proteins Dorsal and Relish (Rel).


The actual alignment was detected with superfamily member cd07881:

Pssm-ID: 447596  Cd Length: 175  Bit Score: 258.97  E-value: 3.97e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831   1 MLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLRNSDIELRKGETD 80
Cdd:cd07881   58 TLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIISNTKVLEIPLLPENNMRASIDCAGILKLRNSDIELRKGETD 137

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 522022831  81 IGRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQR 118
Cdd:cd07881  138 IGRKNTRVRLVFRVHIPQPSGRVLSLQVASNPIECSQR 175
IPT super family cl15674
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 123-223 9.85e-45

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


The actual alignment was detected with superfamily member cd01178:

Pssm-ID: 472823  Cd Length: 101  Bit Score: 151.87  E-value: 9.85e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831 123 LPLVEKQSTDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPVHV 202
Cdd:cd01178    1 LPEIEKKSLNSCSVNGGEELFLTGKNFLKDSKVVFQEKGQDGEAQWEAEATIDKEKSHQNHLVVEVPPYHNKHVAAPVQV 80

                         90       100
                 ....*....|....*....|.
gi 522022831 203 SFYVCNGKRKRSQYQRFTYLP 223
Cdd:cd01178   81 QFYVVNGKRKRSQPQTFTYTP 101
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 240-418 2.47e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831  240 APTCGPVSQGLSPLPRPYYSqqLAMPPDPssclvaGFPPCPQRSTLMPAAPgvspklhdLSPAAYTKGVASPGHCHLGLP 319
Cdd:PHA03247 2678 SPPQRPRRRAARPTVGSLTS--LADPPPP------PPTPEPAPHALVSATP--------LPPGPAAARQASPALPAAPAP 2741

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831  320 QPAGEAPAVQDVPRPVA-----------THPGSPGQPPPALLPQQVSAPPSSSCPPGLEHSLCPSSPSPPLPPATQEPTC 388
Cdd:PHA03247 2742 PAVPAGPATPGGPARPArppttagppapAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPA 2821

                         170       180       190
                  ....*....|....*....|....*....|
gi 522022831  389 LQPCSPACPPATGRPQHLPSTVRRDESPTA 418
Cdd:PHA03247 2822 ASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851
 
Name Accession Description Interval E-value
RHD-n_NFAT cd07881
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ...
 1-118 3.97e-85

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development.


Pssm-ID: 143641  Cd Length: 175  Bit Score: 258.97  E-value: 3.97e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831   1 MLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLRNSDIELRKGETD 80
Cdd:cd07881   58 TLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIISNTKVLEIPLLPENNMRASIDCAGILKLRNSDIELRKGETD 137

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 522022831  81 IGRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQR 118
Cdd:cd07881  138 IGRKNTRVRLVFRVHIPQPSGRVLSLQVASNPIECSQR 175
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
 123-223 9.85e-45

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


Pssm-ID: 238583  Cd Length: 101  Bit Score: 151.87  E-value: 9.85e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831 123 LPLVEKQSTDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPVHV 202
Cdd:cd01178    1 LPEIEKKSLNSCSVNGGEELFLTGKNFLKDSKVVFQEKGQDGEAQWEAEATIDKEKSHQNHLVVEVPPYHNKHVAAPVQV 80

                         90       100
                 ....*....|....*....|.
gi 522022831 203 SFYVCNGKRKRSQYQRFTYLP 223
Cdd:cd01178   81 QFYVVNGKRKRSQPQTFTYTP 101
RHD_dimer pfam16179
Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural ...
 126-223 6.41e-28

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 465045  Cd Length: 102  Bit Score: 106.88  E-value: 6.41e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831  126 VEKQSTDSYPVVGGKKMVLSGHNFL-QDSKVIFVEKApDGHHVWEMEAKTDRDLCKPNS-LVVEIPPFRNQRITSPVHVS 203
Cdd:pfam16179   2 ICRLSLCSGSVTGGEEIILLCEKVLkDDIKVRFYEED-DGQEVWEAEGDFSKTDVHRQVaIVFKTPPYRDPDITEPVTVN 80

                          90       100
                  ....*....|....*....|.
gi 522022831  204 FYVCNGKRK-RSQYQRFTYLP 223
Cdd:pfam16179  81 IQLRRPSDKaTSEPQPFTYLP 101
RHD_DNA_bind pfam00554
Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are ...
 1-116 5.94e-20

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.


Pssm-ID: 425749  Cd Length: 169  Bit Score: 86.59  E-value: 5.94e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831    1 MLQLFIGTADDRLlRPHAfyqvHRITGKTvsttsheailSNTKVLEIPLLPENsMRAVIDCAGILKLRNSDIELRKGE-- 78
Cdd:pfam00554  51 VIRVSLVTKDEPH-RPHP----HSLVGKD----------CKDGVCEVELGPED-MVASFQNLGIQCVKKKDVEEALKEri 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 522022831   79 -TDIGRKN--------------TRVRLVFRVHVPQPSG--RTLSLQVASNPIECS 116
Cdd:pfam00554 115 eLNIDPFNvgfealrqikdmdlNVVRLCFQAFLPDTRGnfTTPLPPVVSNPIYDK 169
IPT smart00429
ig-like, plexins, transcription factors;
123-222 2.79e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 59.74  E-value: 2.79e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831   123 LPLVEKQSTDSYPVVGGKKMVLSGHNFLQDSKVIFvekapdGHHVWEMEAKTDRDlcKPNSLVVEIPPFRNQRITSPVhV 202
Cdd:smart00429   1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFV------EVGVGEAPCTFSPS--SSTAIVCKTPPYHNIPGSVPV-R 71

                           90       100
                   ....*....|....*....|
gi 522022831   203 SFYVCNGKRkRSQYQRFTYL 222
Cdd:smart00429  72 TVGLRNGGV-PSSPQPFTYV 90
PHA03247 PHA03247
large tegument protein UL36; Provisional
 240-418 2.47e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831  240 APTCGPVSQGLSPLPRPYYSqqLAMPPDPssclvaGFPPCPQRSTLMPAAPgvspklhdLSPAAYTKGVASPGHCHLGLP 319
Cdd:PHA03247 2678 SPPQRPRRRAARPTVGSLTS--LADPPPP------PPTPEPAPHALVSATP--------LPPGPAAARQASPALPAAPAP 2741

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831  320 QPAGEAPAVQDVPRPVA-----------THPGSPGQPPPALLPQQVSAPPSSSCPPGLEHSLCPSSPSPPLPPATQEPTC 388
Cdd:PHA03247 2742 PAVPAGPATPGGPARPArppttagppapAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPA 2821

                         170       180       190
                  ....*....|....*....|....*....|
gi 522022831  389 LQPCSPACPPATGRPQHLPSTVRRDESPTA 418
Cdd:PHA03247 2822 ASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851
 
Name Accession Description Interval E-value
RHD-n_NFAT cd07881
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ...
 1-118 3.97e-85

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development.


Pssm-ID: 143641  Cd Length: 175  Bit Score: 258.97  E-value: 3.97e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831   1 MLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLRNSDIELRKGETD 80
Cdd:cd07881   58 TLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIISNTKVLEIPLLPENNMRASIDCAGILKLRNSDIELRKGETD 137

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 522022831  81 IGRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQR 118
Cdd:cd07881  138 IGRKNTRVRLVFRVHIPQPSGRVLSLQVASNPIECSQR 175
RHD-n_NFAT_like cd07927
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ...
 2-117 1.74e-47

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins and similar proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development. This group also contains the N-terminal RHD sub-domain of the non-calcium regulated tonicity-responsive enhancer binding protein (TonEBP), also called NFAT5. Mammalian TonEBP regulates the expression of genes in response to tonicity. It plays a pivotal role in urinary concentrating mechanisms in kidney medulla, by triggering the accumulation of osmolytes that enable renal medullary cells to tolerate high levels of urea and salt.


Pssm-ID: 143648  Cd Length: 161  Bit Score: 161.29  E-value: 1.74e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831   2 LQLFIGTADDRLlRPHAFYQVHRITGKTvSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLRNSDIELRKGETDI 81
Cdd:cd07927   48 LQVFIGTASGRL-KPHAFYQVHRITGKT-TTPCKEKIIGNTKVLEIPLEPKNNMTATIDCAGILKLRNADIELRKGETDI 125

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 522022831  82 GRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQ 117
Cdd:cd07927  126 KKKNTRARLVFRVHIPEKDGRIVSLQTASNPIECSQ 161
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
 123-223 9.85e-45

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


Pssm-ID: 238583  Cd Length: 101  Bit Score: 151.87  E-value: 9.85e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831 123 LPLVEKQSTDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPVHV 202
Cdd:cd01178    1 LPEIEKKSLNSCSVNGGEELFLTGKNFLKDSKVVFQEKGQDGEAQWEAEATIDKEKSHQNHLVVEVPPYHNKHVAAPVQV 80

                         90       100
                 ....*....|....*....|.
gi 522022831 203 SFYVCNGKRKRSQYQRFTYLP 223
Cdd:cd01178   81 QFYVVNGKRKRSQPQTFTYTP 101
RHD-n_TonEBP cd07882
N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding ...
 2-117 1.78e-37

N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the tonicity-responsive enhancer binding protein (TonEBP), also called NFAT5. Mammalian TonEBP regulates the expression of genes in response to tonicity. It plays a pivotal role in urinary concentrating mechanisms in kidney medulla, by triggering the accumulation of osmolytes that enable renal medullary cells to tolerate high levels of urea and salt.


Pssm-ID: 143642  Cd Length: 161  Bit Score: 134.56  E-value: 1.78e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831   2 LQLFIGTADDRLlRPHAFYQVHRITGKTvSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLRNSDIELRKGETDI 81
Cdd:cd07882   48 LQVFVGTDSGRV-KPHGFYQACKVTGRN-TTPCEEVDVEGTTVIEVPLDPTNNMTISVDCVGILKLRNADVEARIGIARS 125

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 522022831  82 GRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQ 117
Cdd:cd07882  126 KKKSTRVRLVFRVIIPRKDGSTLTLQTVSNPILCTQ 161
RHD_dimer pfam16179
Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural ...
 126-223 6.41e-28

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 465045  Cd Length: 102  Bit Score: 106.88  E-value: 6.41e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831  126 VEKQSTDSYPVVGGKKMVLSGHNFL-QDSKVIFVEKApDGHHVWEMEAKTDRDLCKPNS-LVVEIPPFRNQRITSPVHVS 203
Cdd:pfam16179   2 ICRLSLCSGSVTGGEEIILLCEKVLkDDIKVRFYEED-DGQEVWEAEGDFSKTDVHRQVaIVFKTPPYRDPDITEPVTVN 80

                          90       100
                  ....*....|....*....|.
gi 522022831  204 FYVCNGKRK-RSQYQRFTYLP 223
Cdd:pfam16179  81 IQLRRPSDKaTSEPQPFTYLP 101
IPT_TF cd00602
IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated ...
 124-223 1.25e-24

IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region.


Pssm-ID: 238336  Cd Length: 101  Bit Score: 97.74  E-value: 1.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831 124 PLVEKQSTDSYPVVGGKKMVLSGHNFL-QDSKVIFVEKAPdGHHVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPVHV 202
Cdd:cd00602    1 LPICRVSSLSGSVNGGDEVFLLCDKVNkPDIKVWFGEKGP-GETVWEAEAMFRQEDVRQVAIVFKTPPYHNKWITRPVQV 79

                         90       100
                 ....*....|....*....|..
gi 522022831 203 SFYVCNG-KRKRSQYQRFTYLP 223
Cdd:cd00602   80 PIQLVRPdDRKRSEPLTFTYTP 101
RHD-n cd07827
N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology ...
 1-117 3.71e-20

N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal sub-domain, which may be distantly related to the DNA-binding domain found in P53. The C-terminal sub-domain has an immunoglobulin-like fold and serves as a dimerization module that also binds DNA (see cd00102). The RHD is found in NF-kappa B, nuclear factor of activated T-cells (NFAT), the tonicity-responsive enhancer binding protein (TonEBP), and the arthropod proteins Dorsal and Relish (Rel).


Pssm-ID: 143640  Cd Length: 174  Bit Score: 87.42  E-value: 3.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831   1 MLQLFIGTADDRLlRPHAfYQVHRITGKTvsttsheailsnTKVLEIPLLPENSMRAVIDCAGILKLRNSDIELRKGETD 80
Cdd:cd07827   53 KIVVSLVTKDDPP-KPHP-HQLVGKTDCR------------DGVCEVRLGPKNNMTASFNNLGIQCVRKKDVEEALGQRI 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 522022831  81 -----------------IGRKNTRVRLVFRVHVPQPSG-RTLSL-QVASNPIECSQ 117
Cdd:cd07827  119 qlgidpfmvhkgpegnaSDIDLNRVRLCFQAFIEDSDGgFTLPLpPVLSNPIYDKK 174
RHD_DNA_bind pfam00554
Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are ...
 1-116 5.94e-20

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.


Pssm-ID: 425749  Cd Length: 169  Bit Score: 86.59  E-value: 5.94e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831    1 MLQLFIGTADDRLlRPHAfyqvHRITGKTvsttsheailSNTKVLEIPLLPENsMRAVIDCAGILKLRNSDIELRKGE-- 78
Cdd:pfam00554  51 VIRVSLVTKDEPH-RPHP----HSLVGKD----------CKDGVCEVELGPED-MVASFQNLGIQCVKKKDVEEALKEri 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 522022831   79 -TDIGRKN--------------TRVRLVFRVHVPQPSG--RTLSLQVASNPIECS 116
Cdd:pfam00554 115 eLNIDPFNvgfealrqikdmdlNVVRLCFQAFLPDTRGnfTTPLPPVVSNPIYDK 169
IPT smart00429
ig-like, plexins, transcription factors;
123-222 2.79e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 59.74  E-value: 2.79e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831   123 LPLVEKQSTDSYPVVGGKKMVLSGHNFLQDSKVIFvekapdGHHVWEMEAKTDRDlcKPNSLVVEIPPFRNQRITSPVhV 202
Cdd:smart00429   1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFV------EVGVGEAPCTFSPS--SSTAIVCKTPPYHNIPGSVPV-R 71

                           90       100
                   ....*....|....*....|
gi 522022831   203 SFYVCNGKRkRSQYQRFTYL 222
Cdd:smart00429  72 TVGLRNGGV-PSSPQPFTYV 90
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 124-223 5.92e-06

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 44.37  E-value: 5.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831 124 PLVEKQSTDSYPVVGGKKMVLSGHNFL--QDSKVIFVEKAPdghhvwemeakTDRDLCKPNSLVVEIPPFRNQRITsPVH 201
Cdd:cd00102    1 PVITSISPSSGPVSGGTEVTITGSNFGsgSNLRVTFGGGVP-----------CSVLSVSSTAIVCTTPPYANPGPG-PVE 68

                         90       100
                 ....*....|....*....|..
gi 522022831 202 VSFYVCNGkRKRSQYQRFTYLP 223
Cdd:cd00102   69 VTVDRGNG-GITSSPLTFTYVP 89
PHA03247 PHA03247
large tegument protein UL36; Provisional
 240-418 2.47e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831  240 APTCGPVSQGLSPLPRPYYSqqLAMPPDPssclvaGFPPCPQRSTLMPAAPgvspklhdLSPAAYTKGVASPGHCHLGLP 319
Cdd:PHA03247 2678 SPPQRPRRRAARPTVGSLTS--LADPPPP------PPTPEPAPHALVSATP--------LPPGPAAARQASPALPAAPAP 2741

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 522022831  320 QPAGEAPAVQDVPRPVA-----------THPGSPGQPPPALLPQQVSAPPSSSCPPGLEHSLCPSSPSPPLPPATQEPTC 388
Cdd:PHA03247 2742 PAVPAGPATPGGPARPArppttagppapAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPA 2821

                         170       180       190
                  ....*....|....*....|....*....|
gi 522022831  389 LQPCSPACPPATGRPQHLPSTVRRDESPTA 418
Cdd:PHA03247 2822 ASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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