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Conserved domains on  [gi|538919393|ref|NP_001269331|]
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homeobox protein MIXL1 isoform 1 [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10441114)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003677
PubMed:  21557080|26464018|27768937|1357790
SCOP:  4000291

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
87-151 6.23e-22

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 85.24  E-value: 6.23e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 538919393   87 RRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIqllfsplfQVWFQNRRAKSRR 151
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQV--------KVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
87-151 6.23e-22

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 85.24  E-value: 6.23e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 538919393   87 RRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIqllfsplfQVWFQNRRAKSRR 151
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQV--------KVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 86-150 3.56e-19

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 78.06  E-value: 3.56e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 538919393    86 QRRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIqllfsplfQVWFQNRRAKSR 150
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQV--------KVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 87-153 1.28e-18

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 76.90  E-value: 1.28e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 538919393  87 RRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIqllfsplfQVWFQNRRAKSRRQS 153
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQV--------KIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
86-153 2.80e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 57.06  E-value: 2.80e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 538919393  86 QRRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIqllfsplfQVWFQNRRAKSRRQS 153
Cdd:COG5576   51 PKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSV--------QIWFQNKRAKEKKKR 110
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
87-151 6.23e-22

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 85.24  E-value: 6.23e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 538919393   87 RRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIqllfsplfQVWFQNRRAKSRR 151
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQV--------KVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 86-150 3.56e-19

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 78.06  E-value: 3.56e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 538919393    86 QRRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIqllfsplfQVWFQNRRAKSR 150
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQV--------KVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 87-153 1.28e-18

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 76.90  E-value: 1.28e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 538919393  87 RRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIqllfsplfQVWFQNRRAKSRRQS 153
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQV--------KIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
86-153 2.80e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 57.06  E-value: 2.80e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 538919393  86 QRRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIqllfsplfQVWFQNRRAKSRRQS 153
Cdd:COG5576   51 PKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSV--------QIWFQNKRAKEKKKR 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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