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Conserved domains on  [gi|542133124|ref|NP_001269433|]
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melanoma-associated antigen 2 [Homo sapiens]

Protein Classification

MAGE family protein( domain architecture ID 10575428)

MAGE family protein is a tumor-rejection antigen expressed on HLA-A1 of tumor cells and recognized by cytotoxic T-lymphocytes, similar to human Melanoma-associated antigen 3 (MAGE-A3) which may enhance ubiquitin(Ub) ligase activity of RING-type zinc finger-containing E3 Ub-protein ligases and TRIM28, and stimulate p53/TP53 ubiquitination by TRIM28

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAGE_N pfam12440
Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and ...
 5-95 2.11e-36

Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. The family is found in association with pfam01454. This family is the N terminal of various melanoma associated antigens. These are tumour rejection antigens which are expressed on HLA-A1 of tumour cells and they are recognized by cytotoxic T lymphocytes (CTLs).


:

Pssm-ID: 463582 [Multi-domain]  Cd Length: 92  Bit Score: 125.87  E-value: 2.11e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133124    5 QRSQHCKPEEGLEARGEALGLVGAQAPATEEQQTASSSSTLVEVTLGEVPAADSPSPPHSPQGASSFSTTINYTLWRQSD 84
Cdd:pfam12440   1 QKSKLRAREKRRQARSETQGLEGAQATAAEEEESPSSSSPLSGGTPESSPAAGSPSTPQSPQGAPSTTTAAAAVSSTRSD 80

                          90
                  ....*....|.
gi 542133124   85 EGSSNQEEEGP 95
Cdd:pfam12440  81 EGASSQDEESP 91
MAGE super family cl03220
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 116-280 9.33e-11

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


The actual alignment was detected with superfamily member pfam01454:

Pssm-ID: 426270  Cd Length: 205  Bit Score: 60.36  E-value: 9.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133124  116 LVHFLLLKYRAREPVTKAEMLESVLRNCQDF-FPVIFSKASEYLQLVFGIEVVEVVPI--------------------SH 174
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENRKRlFKKVFEEAQKILRDVFGMELVELPAKeekkttvtsqqrraaakssrSK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133124  175 LYILVTCLGLSYDGL-----------LGDNQVMPKTGLLIIVLAIIAIEGDCAPEEKIWEELSMLEVFEG--REDSVFAH 241
Cdd:pfam01454  81 SYILVSTLPPEYRVPaiiwpskapsfVLDQDEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIDTDgtKEIPPLNG 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 542133124  242 PRKLLMQDLVQENYLEYRQVPGSDPA--CYEFLWGPRALIE 280
Cdd:pfam01454 161 NTDDLLKRLVKQGYLVRTKEGASDDGeeIIEYRVGPRAKVE 201
 
Name Accession Description Interval E-value
MAGE_N pfam12440
Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and ...
 5-95 2.11e-36

Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. The family is found in association with pfam01454. This family is the N terminal of various melanoma associated antigens. These are tumour rejection antigens which are expressed on HLA-A1 of tumour cells and they are recognized by cytotoxic T lymphocytes (CTLs).


Pssm-ID: 463582 [Multi-domain]  Cd Length: 92  Bit Score: 125.87  E-value: 2.11e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133124    5 QRSQHCKPEEGLEARGEALGLVGAQAPATEEQQTASSSSTLVEVTLGEVPAADSPSPPHSPQGASSFSTTINYTLWRQSD 84
Cdd:pfam12440   1 QKSKLRAREKRRQARSETQGLEGAQATAAEEEESPSSSSPLSGGTPESSPAAGSPSTPQSPQGAPSTTTAAAAVSSTRSD 80

                          90
                  ....*....|.
gi 542133124   85 EGSSNQEEEGP 95
Cdd:pfam12440  81 EGASSQDEESP 91
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 116-280 9.33e-11

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 60.36  E-value: 9.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133124  116 LVHFLLLKYRAREPVTKAEMLESVLRNCQDF-FPVIFSKASEYLQLVFGIEVVEVVPI--------------------SH 174
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENRKRlFKKVFEEAQKILRDVFGMELVELPAKeekkttvtsqqrraaakssrSK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133124  175 LYILVTCLGLSYDGL-----------LGDNQVMPKTGLLIIVLAIIAIEGDCAPEEKIWEELSMLEVFEG--REDSVFAH 241
Cdd:pfam01454  81 SYILVSTLPPEYRVPaiiwpskapsfVLDQDEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIDTDgtKEIPPLNG 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 542133124  242 PRKLLMQDLVQENYLEYRQVPGSDPA--CYEFLWGPRALIE 280
Cdd:pfam01454 161 NTDDLLKRLVKQGYLVRTKEGASDDGeeIIEYRVGPRAKVE 201
 
Name Accession Description Interval E-value
MAGE_N pfam12440
Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and ...
 5-95 2.11e-36

Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. The family is found in association with pfam01454. This family is the N terminal of various melanoma associated antigens. These are tumour rejection antigens which are expressed on HLA-A1 of tumour cells and they are recognized by cytotoxic T lymphocytes (CTLs).


Pssm-ID: 463582 [Multi-domain]  Cd Length: 92  Bit Score: 125.87  E-value: 2.11e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133124    5 QRSQHCKPEEGLEARGEALGLVGAQAPATEEQQTASSSSTLVEVTLGEVPAADSPSPPHSPQGASSFSTTINYTLWRQSD 84
Cdd:pfam12440   1 QKSKLRAREKRRQARSETQGLEGAQATAAEEEESPSSSSPLSGGTPESSPAAGSPSTPQSPQGAPSTTTAAAAVSSTRSD 80

                          90
                  ....*....|.
gi 542133124   85 EGSSNQEEEGP 95
Cdd:pfam12440  81 EGASSQDEESP 91
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 116-280 9.33e-11

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 60.36  E-value: 9.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133124  116 LVHFLLLKYRAREPVTKAEMLESVLRNCQDF-FPVIFSKASEYLQLVFGIEVVEVVPI--------------------SH 174
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENRKRlFKKVFEEAQKILRDVFGMELVELPAKeekkttvtsqqrraaakssrSK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133124  175 LYILVTCLGLSYDGL-----------LGDNQVMPKTGLLIIVLAIIAIEGDCAPEEKIWEELSMLEVFEG--REDSVFAH 241
Cdd:pfam01454  81 SYILVSTLPPEYRVPaiiwpskapsfVLDQDEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIDTDgtKEIPPLNG 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 542133124  242 PRKLLMQDLVQENYLEYRQVPGSDPA--CYEFLWGPRALIE 280
Cdd:pfam01454 161 NTDDLLKRLVKQGYLVRTKEGASDDGeeIIEYRVGPRAKVE 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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