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Conserved domains on  [gi|544583479|ref|NP_001269780|]
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hairy/enhancer-of-split related with YRPW motif protein 1 isoform c [Homo sapiens]

Protein Classification

HES-5 family bHLH transcription factor( domain architecture ID 10649827)

HES-5 family bHLH (basic helix-loop-helix) transcription factor such as transcription factor HES-5 that acts as transcriptional repressor of genes that require a bHLH protein for their transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ORANGE smart00511
Orange domain; This domain confers specificity among members of the Hairy/E(SPL) family.
 30-76 5.85e-13

Orange domain; This domain confers specificity among members of the Hairy/E(SPL) family.


:

Pssm-ID: 128787  Cd Length: 45  Bit Score: 61.03  E-value: 5.85e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 544583479    30 MDYRSlGFRECLAEVARYLSIIEGLDasDPLRVRLVSHLNNYASQRE 76
Cdd:smart00511   1 SSFRS-GYRECANEVSRFLSQLPGTD--PDVRARLLSHLQTHLNQLL 44
 
Name Accession Description Interval E-value
ORANGE smart00511
Orange domain; This domain confers specificity among members of the Hairy/E(SPL) family.
 30-76 5.85e-13

Orange domain; This domain confers specificity among members of the Hairy/E(SPL) family.


Pssm-ID: 128787  Cd Length: 45  Bit Score: 61.03  E-value: 5.85e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 544583479    30 MDYRSlGFRECLAEVARYLSIIEGLDasDPLRVRLVSHLNNYASQRE 76
Cdd:smart00511   1 SSFRS-GYRECANEVSRFLSQLPGTD--PDVRARLLSHLQTHLNQLL 44
Hairy_orange pfam07527
Hairy Orange; The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and ...
 32-73 5.62e-11

Hairy Orange; The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and Enhancer of Split. The Orange domain is proposed to mediate specific protein-protein interaction between Hairy and Scute.


Pssm-ID: 462193  Cd Length: 40  Bit Score: 55.58  E-value: 5.62e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 544583479   32 YRSlGFRECLAEVARYLSIIEGLDAsdPLRVRLVSHLNNYAS 73
Cdd:pfam07527   2 FRA-GFNECANEVSRFLSTLEGVDP--DLRQRLLNHLQRCLA 40
 
Name Accession Description Interval E-value
ORANGE smart00511
Orange domain; This domain confers specificity among members of the Hairy/E(SPL) family.
 30-76 5.85e-13

Orange domain; This domain confers specificity among members of the Hairy/E(SPL) family.


Pssm-ID: 128787  Cd Length: 45  Bit Score: 61.03  E-value: 5.85e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 544583479    30 MDYRSlGFRECLAEVARYLSIIEGLDasDPLRVRLVSHLNNYASQRE 76
Cdd:smart00511   1 SSFRS-GYRECANEVSRFLSQLPGTD--PDVRARLLSHLQTHLNQLL 44
Hairy_orange pfam07527
Hairy Orange; The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and ...
 32-73 5.62e-11

Hairy Orange; The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and Enhancer of Split. The Orange domain is proposed to mediate specific protein-protein interaction between Hairy and Scute.


Pssm-ID: 462193  Cd Length: 40  Bit Score: 55.58  E-value: 5.62e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 544583479   32 YRSlGFRECLAEVARYLSIIEGLDAsdPLRVRLVSHLNNYAS 73
Cdd:pfam07527   2 FRA-GFNECANEVSRFLSTLEGVDP--DLRQRLLNHLQRCLA 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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